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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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70 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  AGE-RAGE signaling pathway in diabetic complications 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 2  Alzheimer disease 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 3  Amoebiasis 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 4  Amphetamine addiction 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 5  Amyotrophic lateral sclerosis (ALS) 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 6  Axon guidance 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 7  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 8  Breast cancer 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 9  C-type lectin receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 10  Calcium signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 11  Cell cycle 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 12  Cellular senescence 
 8 genes, 2 drugs (DrugBank), 46 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 13  cGMP-PKG signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 14  Chagas disease (American trypanosomiasis) 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 15  Chronic myeloid leukemia 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 16  Colorectal cancer 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 17  Cytokine-cytokine receptor interaction 
 5 genes, 3 drugs (DrugBank), 24 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 18  Dilated cardiomyopathy (DCM) 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 19  Dopaminergic synapse 
 3 genes, 1 drug (DrugBank), 44 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 20  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] PTH1R   D06078   Teriparatide   [7] 46, 65, 68, 70, 71, 235, 274 
 21  FoxO signaling pathway 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 22  Gastric cancer 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 23  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 24  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 25  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 26  Hepatitis B 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 27  Hepatocellular carcinoma 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 28  Hippo signaling pathway 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 29  Human cytomegalovirus infection 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 30  Human immunodeficiency virus 1 infection 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 31  Human T-cell leukemia virus 1 infection 
 9 genes, 6 drugs (DrugBank), 54 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 D00941   Pamidronic acid   [2] 271, 274 
 D07281 
 D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 32  Hypertrophic cardiomyopathy (HCM) 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 33  Inflammatory bowel disease (IBD) 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 34  Influenza A 
 1 gene, 4 drugs (DrugBank), 16 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 D00941   Pamidronic acid   [2] 271, 274 
 D07281 
 D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 35  Intestinal immune network for IgA production 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 36  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 37  Kaposi sarcoma-associated herpesvirus infection 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 38  Leishmaniasis 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 39  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 40  Malaria 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 41  MAPK signaling pathway 
 8 genes, 2 drugs (DrugBank), 46 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 42  Metabolic pathways 
 1 gene, 4 drugs (DrugBank), 16 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 D00941   Pamidronic acid   [2] 271, 274 
 D07281 
 D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 43  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 44  Natural killer cell mediated cytotoxicity 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 45  Neuroactive ligand-receptor interaction 
 2 genes, 2 drugs (DrugBank), 23 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] PTH1R   D06078   Teriparatide   [7] 46, 65, 68, 70, 71, 235, 274 
 46  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 47  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 48  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 49  Osteoclast differentiation 
 8 genes, 3 drugs (DrugBank), 49 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [2] TGFB1, TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 50  Oxytocin signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 51  Pancreatic cancer 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 52  Parathyroid hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 12 diseases shown 		  [1] PTH1R   D06078   Teriparatide   [7] 46, 65, 68, 70, 71, 235, 274 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 53  Pathways in cancer 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 54  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 55  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 56  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 57  Proteoglycans in cancer 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] TGFB1, TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 58  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 59  Renal cell carcinoma 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 60  Renin secretion 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 61  Rheumatoid arthritis 
 4 genes, 2 drugs (DrugBank), 10 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 62  T cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 63  Terpenoid backbone biosynthesis 
 1 gene, 4 drugs (DrugBank), 16 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 D00941   Pamidronic acid   [2] 271, 274 
 D07281 
 D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 64  TGF-beta signaling pathway 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 65  Th1 and Th2 cell differentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 66  Th17 cell differentiation 
 6 genes, 2 drugs (DrugBank), 46 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 67  Toxoplasmosis 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 68  Tuberculosis 
 8 genes, 2 drugs (DrugBank), 46 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 69  VEGF signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 70  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 

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