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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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161 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [2] FLT3, KIT   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 2  Adipocytokine signaling pathway 
 1 gene, 4 drugs (DrugBank), 32 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 3  Adrenergic signaling in cardiomyocytes 
 7 genes, 2 drugs (DrugBank), 2 diseases shown 		  [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNQ1, SCN5A   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] BCL2   D10679   Venetoclax   [1] 28 
 4  African trypanosomiasis 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 5  AGE-RAGE signaling pathway in diabetic complications 
 3 genes, 6 drugs (DrugBank), 32 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNJ5   D00636   Amiodarone   [2] 28, 127 
 D02910 
 7  Allograft rejection 
 1 gene, 4 drugs (DrugBank), 32 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 8  Alzheimer disease 
 6 genes, 5 drugs (DrugBank), 60 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  Amoebiasis 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Amphetamine addiction 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 11  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ADRA1A   D00636   Amiodarone   [2] 28, 127 
 D02910 
 12  Amyotrophic lateral sclerosis (ALS) 
 7 genes, 6 drugs (DrugBank), 60 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Antifolate resistance 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 14  Antigen processing and presentation 
 1 gene, 4 drugs (DrugBank), 32 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Apoptosis 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Apoptosis - multiple species 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 17  Arachidonic acid metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PTGS2   D00130   Diflunisal   [1] 28 
 18  Asthma 
 1 gene, 4 drugs (DrugBank), 32 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 19  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 20  Axon guidance 
 6 genes, 2 drugs (DrugBank), 52 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 21  B cell receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 44 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 22  Breast cancer 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [2] FLT4, KIT   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 23  C-type lectin receptor signaling pathway 
 8 genes, 7 drugs (DrugBank), 60 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 24  Calcium signaling pathway 
 12 genes, 5 drugs (DrugBank), 53 diseases shown 		  [4] ADRA1A, ADRA1B, ADRA1D, ADRB1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 25  cAMP signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ADRB1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 26  Cell cycle 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 27  Cellular senescence 
 6 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 28  Central carbon metabolism in cancer 
 5 genes, 2 drugs (DrugBank), 11 diseases shown 		  [5] FLT3, KIT, PDGFRA, PDGFRB, RET   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 29  cGMP-PKG signaling pathway 
 10 genes, 2 drugs (DrugBank), 45 diseases shown 		  [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNJ8   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 30  Chagas disease (American trypanosomiasis) 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 31  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PTGS2   D00130   Diflunisal   [1] 28 
 32  Choline metabolism in cancer 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 33  Cholinergic synapse 
 4 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [3] KCNJ12, KCNJ3, KCNQ1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 34  Chronic myeloid leukemia 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 35  Circadian entrainment 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] KCNJ3, KCNJ5   D00636   Amiodarone   [2] 28, 127 
 D02910 
 36  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 37  Cytokine-cytokine receptor interaction 
 8 genes, 9 drugs (DrugBank), 45 diseases shown 		  [1] CSF1   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] CSF2RA   D05803   Sargramostim   [6] 6, 28, 60, 62, 96, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 38  Cytosolic DNA-sensing pathway 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 39  Dilated cardiomyopathy (DCM) 
 2 genes, 5 drugs (DrugBank), 33 diseases shown 		  [1] ADRB1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 40  Dopaminergic synapse 
 7 genes, 3 drugs (DrugBank), 46 diseases shown 		  [1] COMT   D00786   Tolcapone   [3] 6, 28, 127 
 [3] KCNJ3, KCNJ5, SCN1A   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 41  Drug metabolism - other enzymes 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 42  EGFR tyrosine kinase inhibitor resistance 
 5 genes, 5 drugs (DrugBank), 13 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [3] KDR, PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 43  Endocrine resistance 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 44  Endocytosis 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D06402   Sunitinib   [2] 28, 34 
 D08552 
 45  Epstein-Barr virus infection 
 6 genes, 8 drugs (DrugBank), 34 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 46  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 47  Estrogen signaling pathway 
 3 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [2] KCNJ3, KCNJ5   D00636   Amiodarone   [2] 28, 127 
 D02910 
 48  Fc epsilon RI signaling pathway 
 2 genes, 5 drugs (DrugBank), 33 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 49  Fluid shear stress and atherosclerosis 
 3 genes, 6 drugs (DrugBank), 32 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] KDR   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 50  Focal adhesion 
 6 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [5] FLT1, FLT4, KDR, PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 51  FoxO signaling pathway 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 52  Gap junction 
 3 genes, 3 drugs (DrugBank), 12 diseases shown 		  [1] ADRB1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 53  Gastric acid secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNQ1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 54  Gastric cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 55  Glioma 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 56  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 57  Glutamatergic synapse 
 6 genes, 2 drugs (DrugBank), 45 diseases shown 		  [1] KCNJ3   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 58  Glutathione metabolism 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 59  GnRH secretion 
 3 genes, 1 drug (DrugBank), 2 diseases shown 		  [3] KCNJ11, KCNJ3, KCNJ5   D00636   Amiodarone   [2] 28, 127 
 D02910 
 60  Graft-versus-host disease 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 61  Hedgehog signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 62  Hematopoietic cell lineage 
 8 genes, 10 drugs (DrugBank), 50 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [3] CSF1, FLT3, KIT   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] CSF2RA   D05803   Sargramostim   [6] 6, 28, 60, 62, 96, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 63  Hepatitis B 
 4 genes, 7 drugs (DrugBank), 33 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] IFNAR1   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 64  Hepatitis C 
 3 genes, 5 drugs (DrugBank), 33 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 65  Herpes simplex virus 1 infection 
 6 genes, 7 drugs (DrugBank), 33 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 66  HIF-1 signaling pathway 
 3 genes, 4 drugs (DrugBank), 6 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] FLT1   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 67  Human cytomegalovirus infection 
 9 genes, 9 drugs (DrugBank), 64 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D06402   Sunitinib   [2] 28, 34 
 D08552 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 68  Human immunodeficiency virus 1 infection 
 7 genes, 6 drugs (DrugBank), 60 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 69  Human papillomavirus infection 
 5 genes, 7 drugs (DrugBank), 33 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 70  Human T-cell leukemia virus 1 infection 
 8 genes, 6 drugs (DrugBank), 60 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 71  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 72  IL-17 signaling pathway 
 3 genes, 6 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 73  Inflammatory bowel disease (IBD) 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 74  Influenza A 
 4 genes, 6 drugs (DrugBank), 33 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 75  Insulin resistance 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 76  Insulin secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNJ11   D00636   Amiodarone   [2] 28, 127 
 D02910 
 77  Intestinal immune network for IgA production 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 78  JAK-STAT signaling pathway 
 8 genes, 8 drugs (DrugBank), 35 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] CSF2RA   D05803   Sargramostim   [6] 6, 28, 60, 62, 96, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 79  Kaposi sarcoma-associated herpesvirus infection 
 9 genes, 5 drugs (DrugBank), 51 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 80  Legionellosis 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 81  Leishmaniasis 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] PTGS2   D00130   Diflunisal   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 82  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 83  Malaria 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 84  MAPK signaling pathway 
 14 genes, 7 drugs (DrugBank), 64 diseases shown 		  [8] CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 85  Measles 
 4 genes, 4 drugs (DrugBank), 10 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 86  Melanogenesis 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D06402   Sunitinib   [2] 28, 34 
 D08552 
 87  Melanoma 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 88  Metabolic pathways 
 6 genes, 6 drugs (DrugBank), 39 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [1] COMT   D00786   Tolcapone   [3] 6, 28, 127 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 89  MicroRNAs in cancer 
 5 genes, 4 drugs (DrugBank), 11 diseases shown 		  [2] ABL1, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] BCL2   D10679   Venetoclax   [1] 28 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 90  Morphine addiction 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] KCNJ3, KCNJ5   D00636   Amiodarone   [2] 28, 127 
 D02910 
 91  mTOR signaling pathway 
 1 gene, 4 drugs (DrugBank), 32 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  Natural killer cell mediated cytotoxicity 
 8 genes, 6 drugs (DrugBank), 61 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 93  Necroptosis 
 4 genes, 6 drugs (DrugBank), 33 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 94  Neuroactive ligand-receptor interaction 
 5 genes, 2 drugs (DrugBank), 21 diseases shown 		  [4] ADRA1A, ADRA1B, ADRA1D, ADRB1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] NR3C1   D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 95  Neurotrophin signaling pathway 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] BCL2   D10679   Venetoclax   [1] 28 
 96  NF-kappa B signaling pathway 
 5 genes, 7 drugs (DrugBank), 33 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 97  Nicotinate and nicotinamide metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 98  NOD-like receptor signaling pathway 
 5 genes, 7 drugs (DrugBank), 33 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 99  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 100  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 101  Osteoclast differentiation 
 10 genes, 8 drugs (DrugBank), 61 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [1] CSF1   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 102  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PTGS2   D00130   Diflunisal   [1] 28 
 103  Oxytocin signaling pathway 
 10 genes, 4 drugs (DrugBank), 45 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [3] KCNJ12, KCNJ3, KCNJ5   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 104  p53 signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 105  Pancreatic secretion 
 2 genes, 2 drugs (DrugBank), 3 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [1] KCNQ1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 106  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 107  Pathogenic Escherichia coli infection 
 3 genes, 6 drugs (DrugBank), 37 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 108  Pathways in cancer 
 14 genes, 9 drugs (DrugBank), 35 diseases shown 		  [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] CSF2RA   D05803   Sargramostim   [6] 6, 28, 60, 62, 96, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [6] FLT3, FLT4, KIT, PDGFRA, PDGFRB, RET   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 109  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 110  Pertussis 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 111  Phospholipase D signaling pathway 
 3 genes, 2 drugs (DrugBank), 11 diseases shown 		  [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] KIT, PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 112  PI3K-Akt signaling pathway 
 13 genes, 7 drugs (DrugBank), 34 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [8] CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 113  Platelet activation 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 114  Platinum drug resistance 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [2] TOP2A, TOP2B   D03899   Doxorubicin   [6] 26, 28, 34, 61, 63, 331 
 D00125   Etoposide   [11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 
 D04107 
 115  Primary immunodeficiency 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 116  Prion diseases 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 117  Prostate cancer 
 3 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 118  Proteasome 
 1 gene, 3 drugs (DrugBank), 15 diseases shown 		  [1] PSMB5   D03150   Bortezomib   [13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 D08880   Carfilzomib   [1] 28 
 D10130   Ixazomib   [4] 13, 16, 28, 61 
 119  Protein digestion and absorption 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNQ1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 120  Protein processing in endoplasmic reticulum 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 121  Proteoglycans in cancer 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] KDR   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 122  Purine metabolism 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 123  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 124  Rap1 signaling pathway 
 7 genes, 2 drugs (DrugBank), 11 diseases shown 		  [7] CSF1, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 125  Ras signaling pathway 
 9 genes, 2 drugs (DrugBank), 11 diseases shown 		  [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [8] CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 126  Regulation of actin cytoskeleton 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D06402   Sunitinib   [2] 28, 34 
 D08552 
 127  Regulation of lipolysis in adipocytes 
 2 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] ADRB1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 128  Renin secretion 
 6 genes, 2 drugs (DrugBank), 45 diseases shown 		  [1] ADRB1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 129  Retrograde endocannabinoid signaling 
 3 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] KCNJ3, KCNJ5   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 130  Rheumatoid arthritis 
 4 genes, 6 drugs (DrugBank), 32 diseases shown 		  [2] CSF1, FLT1   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 131  RIG-I-like receptor signaling pathway 
 1 gene, 4 drugs (DrugBank), 32 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 132  Salivary secretion 
 5 genes, 2 drugs (DrugBank), 3 diseases shown 		  [4] ADRA1A, ADRA1B, ADRA1D, ADRB1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] CD38   D10777   Daratumumab   [2] 28, 222 
 133  Salmonella infection 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 134  Serotonergic synapse 
 3 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] KCNJ3, KCNJ5   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 135  Shigellosis 
 3 genes, 6 drugs (DrugBank), 37 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 136  Small cell lung cancer 
 2 genes, 2 drugs (DrugBank), 1 disease shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 137  Sphingolipid signaling pathway 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 138  Steroid hormone biosynthesis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] COMT   D00786   Tolcapone   [3] 6, 28, 127 
 139  Systemic lupus erythematosus 
 1 gene, 4 drugs (DrugBank), 32 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 140  T cell receptor signaling pathway 
 6 genes, 5 drugs (DrugBank), 60 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 141  Taste transduction 
 3 genes, 1 drug (DrugBank), 2 diseases shown 		  [3] SCN2A, SCN3A, SCN9A   D00636   Amiodarone   [2] 28, 127 
 D02910 
 142  TGF-beta signaling pathway 
 1 gene, 4 drugs (DrugBank), 32 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 143  Th1 and Th2 cell differentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 144  Th17 cell differentiation 
 6 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 145  Thyroid cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] RET   D06402   Sunitinib   [2] 28, 34 
 D08552 
 146  Thyroid hormone synthesis 
 1 gene, 2 drugs (DrugBank), 1 disease shown 		  [1] TTR   D10940   Inotersen   [1] 28 
 D09673   Tafamidis   [1] 28 
 147  TNF signaling pathway 
 5 genes, 7 drugs (DrugBank), 32 diseases shown 		  [1] CSF1   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 148  Toll-like receptor signaling pathway 
 4 genes, 6 drugs (DrugBank), 33 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 149  Toxoplasmosis 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 150  Transcriptional misregulation in cancer 
 3 genes, 3 drugs (DrugBank), 6 diseases shown 		  [2] FLT1, FLT3   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 151  Tuberculosis 
 8 genes, 7 drugs (DrugBank), 60 diseases shown 		  [1] BCL2   D10679   Venetoclax   [1] 28 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 152  Type I diabetes mellitus 
 2 genes, 4 drugs (DrugBank), 32 diseases shown 		  [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 153  Type II diabetes mellitus 
 2 genes, 5 drugs (DrugBank), 33 diseases shown 		  [1] KCNJ11   D00636   Amiodarone   [2] 28, 127 
 D02910 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 154  Tyrosine metabolism 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] COMT   D00786   Tolcapone   [3] 6, 28, 127 
 155  Vascular smooth muscle contraction 
 3 genes, 1 drug (DrugBank), 2 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00636   Amiodarone   [2] 28, 127 
 D02910 
 156  VEGF signaling pathway 
 7 genes, 3 drugs (DrugBank), 45 diseases shown 		  [1] KDR   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] PTGS2   D00130   Diflunisal   [1] 28 
 157  Vibrio cholerae infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNQ1   D00636   Amiodarone   [2] 28, 127 
 D02910 
 158  Viral myocarditis 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 159  Viral protein interaction with cytokine and cytokine receptor 
 4 genes, 6 drugs (DrugBank), 32 diseases shown 		  [1] CSF1   D06402   Sunitinib   [2] 28, 34 
 D08552 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 160  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 161  Yersinia infection 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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