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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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34 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Allograft rejection 
 3 genes, 3 drugs (DrugBank), 27 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 2  Antifolate resistance 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 3  Asthma 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 4  Autoimmune thyroid disease 
 3 genes, 3 drugs (DrugBank), 27 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 5  Cell adhesion molecules (CAMs) 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 6  cGMP-PKG signaling pathway 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] OPRD1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 7  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] C5AR1   D11093   Avacopan   [4] 43, 44, 222, 223 
 8  Cytokine-cytokine receptor interaction 
 3 genes, 4 drugs (DrugBank), 11 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 [1] IL5RA   D09874   Benralizumab   [2] 44, 45 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 9  Estrogen signaling pathway 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 10  Fc epsilon RI signaling pathway 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 11  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 12  Graft-versus-host disease 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 13  Hematopoietic cell lineage 
 3 genes, 4 drugs (DrugBank), 43 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 [1] IL5RA   D09874   Benralizumab   [2] 44, 45 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 14  IL-17 signaling pathway 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 15  Inflammatory bowel disease (IBD) 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 16  Intestinal immune network for IgA production 
 4 genes, 4 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 17  JAK-STAT signaling pathway 
 2 genes, 3 drugs (DrugBank), 4 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 [1] IL5RA   D09874   Benralizumab   [2] 44, 45 
 18  Kaposi sarcoma-associated herpesvirus infection 
 1 gene, 1 drug (DrugBank), 24 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 19  Metabolic pathways 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 20  Morphine addiction 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 21  Neuroactive ligand-receptor interaction 
 5 genes, 5 drugs (DrugBank), 60 diseases shown 		  [1] C5AR1   D11093   Avacopan   [4] 43, 44, 222, 223 
 [1] NR3C1   D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 D00385   Triamcinolone   [18] 6, 10, 13, 35, 40, 41, 42, 43, 44, 45, 46, 56, 70, 90, 96, 97, 226, 298 
 D00983 
 D00984 
 D00985 
 D06216 
 [3] OPRD1, OPRK1, OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 22  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 23  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 24  Pathways in cancer 
 2 genes, 3 drugs (DrugBank), 4 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 [1] IL5RA   D09874   Benralizumab   [2] 44, 45 
 25  Rheumatoid arthritis 
 3 genes, 2 drugs (DrugBank), 25 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 26  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] OPRD1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 27  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] C5AR1   D11093   Avacopan   [4] 43, 44, 222, 223 
 28  Systemic lupus erythematosus 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 29  T cell receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 30  Th1 and Th2 cell differentiation 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] IL5   D04923   Mepolizumab   [4] 44, 45, 98, 162 
 D08985   Reslizumab   [3] 44, 45, 98 
 31  Toll-like receptor signaling pathway 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 32  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 24 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 33  Type I diabetes mellitus 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 34  Viral myocarditis 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 

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