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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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197 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 2 genes, 3 drugs (DrugBank), 41 diseases shown 		  [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adherens junction 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 3  Adipocytokine signaling pathway 
 3 genes, 5 drugs (DrugBank), 51 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  Adrenergic signaling in cardiomyocytes 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 5  African trypanosomiasis 
 4 genes, 4 drugs (DrugBank), 28 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  AGE-RAGE signaling pathway in diabetic complications 
 9 genes, 6 drugs (DrugBank), 29 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 7  Alcoholism 
 1 gene, 3 drugs (DrugBank), 6 diseases shown 		  [1] DRD2   D00702   Buspirone   [2] 6, 51 
 D07593 
 D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D01348   Terguride   [2] 51, 86 
 8  Aldosterone synthesis and secretion 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 9  Allograft rejection 
 4 genes, 4 drugs (DrugBank), 37 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Alzheimer disease 
 11 genes, 6 drugs (DrugBank), 46 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Amoebiasis 
 7 genes, 5 drugs (DrugBank), 29 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 12  Amphetamine addiction 
 7 genes, 2 drugs (DrugBank), 32 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 13  AMPK signaling pathway 
 2 genes, 4 drugs (DrugBank), 52 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 14  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 4 drugs (DrugBank), 42 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Antifolate resistance 
 5 genes, 5 drugs (DrugBank), 48 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Antigen processing and presentation 
 1 gene, 3 drugs (DrugBank), 25 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 17  Apelin signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDE3B   D01896   Cilostazol   [2] 51, 70 
 18  Apoptosis 
 1 gene, 3 drugs (DrugBank), 25 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 19  Arachidonic acid metabolism 
 2 genes, 2 drugs (DrugBank), 16 diseases shown 		  [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 20  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 21  Asthma 
 2 genes, 3 drugs (DrugBank), 25 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 22  Autoimmune thyroid disease 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 23  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 24  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 25  Axon guidance 
 7 genes, 4 drugs (DrugBank), 39 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 26  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 27  Bile secretion 
 1 gene, 3 drugs (DrugBank), 29 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 28  Bladder cancer 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FGFR3   D10481   Nintedanib   [4] 51, 85, 89, 228 
 29  Breast cancer 
 5 genes, 5 drugs (DrugBank), 42 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] FGFR1, FLT4   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 30  C-type lectin receptor signaling pathway 
 10 genes, 7 drugs (DrugBank), 52 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 31  Calcium signaling pathway 
 19 genes, 15 drugs (DrugBank), 50 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] HRH1   D00300   Diphenhydramine   [5] 49, 51, 70, 86, 256 
 D00669 
 D02419 
 D03285 
 D03360 
 D03854 
 [1] HTR4   D09205   Prucalopride   [3] 13, 51, 96 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGER1   D00180   Alprostadil   [2] 51, 70 
 D02705 
 [1] TBXA2R   D01896   Cilostazol   [2] 51, 70 
 D04500   Ifetroban   [3] 51, 86, 113 
 32  cAMP signaling pathway 
 11 genes, 10 drugs (DrugBank), 22 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D01348   Terguride   [2] 51, 86 
 [2] DRD2, HTR1A   D00702   Buspirone   [2] 6, 51 
 D07593 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] HTR4   D09205   Prucalopride   [3] 13, 51, 96 
 [2] PDE3A, PDE3B   D01896   Cilostazol   [2] 51, 70 
 [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 33  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 34  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 35  Cell adhesion molecules (CAMs) 
 3 genes, 2 drugs (DrugBank), 25 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 36  Cell cycle 
 4 genes, 3 drugs (DrugBank), 15 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 37  Cellular senescence 
 12 genes, 7 drugs (DrugBank), 58 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] IL1A   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL1A, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 38  Central carbon metabolism in cancer 
 8 genes, 5 drugs (DrugBank), 42 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 39  cGMP-PKG signaling pathway 
 17 genes, 10 drugs (DrugBank), 45 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [2] PDE3A, PDE3B   D01896   Cilostazol   [2] 51, 70 
 [1] PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 40  Chagas disease (American trypanosomiasis) 
 8 genes, 5 drugs (DrugBank), 29 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 41  Chemical carcinogenesis 
 1 gene, 2 drugs (DrugBank), 16 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 42  Chemokine signaling pathway 
 4 genes, 3 drugs (DrugBank), 18 diseases shown 		  [1] CCL2   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [2] JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 43  Choline metabolism in cancer 
 4 genes, 5 drugs (DrugBank), 42 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 44  Cholinergic synapse 
 5 genes, 2 drugs (DrugBank), 12 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 45  Chronic myeloid leukemia 
 4 genes, 3 drugs (DrugBank), 15 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 46  Circadian entrainment 
 5 genes, 2 drugs (DrugBank), 9 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 47  Cocaine addiction 
 1 gene, 3 drugs (DrugBank), 6 diseases shown 		  [1] DRD2   D00702   Buspirone   [2] 6, 51 
 D07593 
 D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D01348   Terguride   [2] 51, 86 
 48  Collecting duct acid secretion 
 2 genes, 2 drugs (DrugBank), 16 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 D00724   Rabeprazole   [2] 2, 51 
 D08463 
 49  Colorectal cancer 
 5 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 50  Cortisol synthesis and secretion 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 51  Cushing syndrome 
 5 genes, 2 drugs (DrugBank), 8 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 52  Cytokine-cytokine receptor interaction 
 17 genes, 13 drugs (DrugBank), 54 diseases shown 		  [6] CCL2, IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CSF2RA   D05712   Regramostim   [4] 11, 46, 51, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] IL17RA   D10061   Brodalumab   [2] 37, 51 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] PRL   D01348   Terguride   [2] 51, 86 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFRSF8   D09587   Brentuximab vedotin   [2] 49, 51 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 53  Cytosolic DNA-sensing pathway 
 2 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 54  Dilated cardiomyopathy (DCM) 
 8 genes, 5 drugs (DrugBank), 27 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 55  Dopaminergic synapse 
 6 genes, 5 drugs (DrugBank), 35 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] DRD2   D00702   Buspirone   [2] 6, 51 
 D07593 
 D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D01348   Terguride   [2] 51, 86 
 [3] PPP3CA, PPP3CB, PPP3CC   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 56  Drug metabolism - other enzymes 
 3 genes, 4 drugs (DrugBank), 38 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 57  EGFR tyrosine kinase inhibitor resistance 
 11 genes, 9 drugs (DrugBank), 57 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [5] FGFR2, FGFR3, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 58  Endocrine resistance 
 2 genes, 2 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 59  Endocytosis 
 5 genes, 5 drugs (DrugBank), 18 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [3] FGFR2, FGFR3, PDGFRA   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 60  Endometrial cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 61  Epithelial cell signaling in Helicobacter pylori infection 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 62  Epstein-Barr virus infection 
 5 genes, 4 drugs (DrugBank), 26 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 63  ErbB signaling pathway 
 3 genes, 4 drugs (DrugBank), 41 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 64  Estrogen signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] OPRM1   D08639   Trimebutine   [1] 51 
 65  Fc epsilon RI signaling pathway 
 1 gene, 3 drugs (DrugBank), 25 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 66  Fluid shear stress and atherosclerosis 
 6 genes, 6 drugs (DrugBank), 31 diseases shown 		  [4] CCL2, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [1] KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 67  Focal adhesion 
 6 genes, 4 drugs (DrugBank), 15 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [5] FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 68  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 69  FoxO signaling pathway 
 6 genes, 4 drugs (DrugBank), 16 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 70  GABAergic synapse 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 71  Gap junction 
 16 genes, 9 drugs (DrugBank), 22 diseases shown 		  [1] DRD2   D00702   Buspirone   [2] 6, 51 
 D07593 
 D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D01348   Terguride   [2] 51, 86 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D09587   Brentuximab vedotin   [2] 49, 51 
 72  Gastric acid secretion 
 2 genes, 2 drugs (DrugBank), 16 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 D00724   Rabeprazole   [2] 2, 51 
 D08463 
 73  Gastric cancer 
 6 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FGFR2   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 74  Glioma 
 4 genes, 5 drugs (DrugBank), 42 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 75  Glucagon signaling pathway 
 6 genes, 2 drugs (DrugBank), 31 diseases shown 		  [1] PDE3B   D01896   Cilostazol   [2] 51, 70 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 76  Glutamatergic synapse 
 7 genes, 2 drugs (DrugBank), 32 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 77  Glutathione metabolism 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 78  GnRH secretion 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 79  GnRH signaling pathway 
 6 genes, 3 drugs (DrugBank), 12 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] GNRHR   D00989   Leuprolide   [5] 1, 2, 3, 51, 76 
 80  Graft-versus-host disease 
 6 genes, 5 drugs (DrugBank), 39 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 81  Growth hormone synthesis, secretion and action 
 6 genes, 3 drugs (DrugBank), 42 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 82  Hematopoietic cell lineage 
 9 genes, 10 drugs (DrugBank), 69 diseases shown 		  [1] CSF2RA   D05712   Regramostim   [4] 11, 46, 51, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 83  Hepatitis B 
 9 genes, 5 drugs (DrugBank), 27 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 84  Hepatitis C 
 4 genes, 5 drugs (DrugBank), 28 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 85  Hepatocellular carcinoma 
 6 genes, 4 drugs (DrugBank), 37 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 86  Herpes simplex virus 1 infection 
 8 genes, 6 drugs (DrugBank), 53 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  HIF-1 signaling pathway 
 5 genes, 6 drugs (DrugBank), 52 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 88  Hippo signaling pathway 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 89  Human cytomegalovirus infection 
 17 genes, 16 drugs (DrugBank), 74 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGER1   D00180   Alprostadil   [2] 51, 70 
 D02705 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 90  Human immunodeficiency virus 1 infection 
 8 genes, 6 drugs (DrugBank), 58 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 91  Human papillomavirus infection 
 7 genes, 10 drugs (DrugBank), 58 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  Human T-cell leukemia virus 1 infection 
 12 genes, 6 drugs (DrugBank), 44 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 93  Hypertrophic cardiomyopathy (HCM) 
 9 genes, 5 drugs (DrugBank), 27 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 94  IL-17 signaling pathway 
 6 genes, 7 drugs (DrugBank), 40 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL17RA   D10061   Brodalumab   [2] 37, 51 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 95  Inflammatory bowel disease (IBD) 
 8 genes, 5 drugs (DrugBank), 29 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 96  Inflammatory mediator regulation of TRP channels 
 2 genes, 3 drugs (DrugBank), 17 diseases shown 		  [1] HRH1   D00300   Diphenhydramine   [5] 49, 51, 70, 86, 256 
 D00669 
 D02419 
 D03285 
 D03360 
 D03854 
 [1] IL1B   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D06635   Rilonacept   [4] 51, 106, 107, 266 
 97  Influenza A 
 8 genes, 5 drugs (DrugBank), 28 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 98  Insulin resistance 
 3 genes, 4 drugs (DrugBank), 50 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 99  Insulin secretion 
 5 genes, 3 drugs (DrugBank), 16 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] SNAP25   D02735   Botulinum Toxin Type B   [3] 2, 6, 51 
 D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 100  Insulin signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDE3B   D01896   Cilostazol   [2] 51, 70 
 101  Intestinal immune network for IgA production 
 7 genes, 6 drugs (DrugBank), 34 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 102  JAK-STAT signaling pathway 
 14 genes, 12 drugs (DrugBank), 66 diseases shown 		  [1] CSF2RA   D05712   Regramostim   [4] 11, 46, 51, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PRL   D01348   Terguride   [2] 51, 86 
 103  Kaposi sarcoma-associated herpesvirus infection 
 12 genes, 8 drugs (DrugBank), 66 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 104  Legionellosis 
 3 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 105  Leishmaniasis 
 10 genes, 8 drugs (DrugBank), 40 diseases shown 		  [4] IL10, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 106  Leukocyte transendothelial migration 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 107  Long-term depression 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 108  Long-term potentiation 
 6 genes, 2 drugs (DrugBank), 32 diseases shown 		  [1] CACNA1C   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 109  Longevity regulating pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 110  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 111  Malaria 
 8 genes, 5 drugs (DrugBank), 29 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 112  MAPK signaling pathway 
 25 genes, 11 drugs (DrugBank), 53 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 113  Measles 
 6 genes, 4 drugs (DrugBank), 20 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 114  Melanogenesis 
 2 genes, 4 drugs (DrugBank), 19 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 115  Melanoma 
 4 genes, 4 drugs (DrugBank), 15 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [3] FGFR1, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 116  Metabolic pathways 
 17 genes, 17 drugs (DrugBank), 80 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 D00724   Rabeprazole   [2] 2, 51 
 D08463 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] PDE3A, PDE3B   D01896   Cilostazol   [2] 51, 70 
 [2] PDE4A, PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 117  MicroRNAs in cancer 
 8 genes, 8 drugs (DrugBank), 49 diseases shown 		  [2] ABL1, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] ABL1, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [3] FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 118  Morphine addiction 
 4 genes, 3 drugs (DrugBank), 6 diseases shown 		  [1] OPRM1   D08639   Trimebutine   [1] 51 
 [2] PDE3A, PDE3B   D01896   Cilostazol   [2] 51, 70 
 [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 119  mTOR signaling pathway 
 2 genes, 4 drugs (DrugBank), 50 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 120  Natural killer cell mediated cytotoxicity 
 6 genes, 4 drugs (DrugBank), 42 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 121  Necroptosis 
 7 genes, 5 drugs (DrugBank), 28 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 122  Neuroactive ligand-receptor interaction 
 15 genes, 20 drugs (DrugBank), 67 diseases shown 		  [1] CNR2   D11312   Ajulemic acid   [3] 50, 51, 299 
 [1] DRD2   D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 [2] DRD2, HTR1A   D00702   Buspirone   [2] 6, 51 
 D07593 
 [2] DRD2, PRL   D01348   Terguride   [2] 51, 86 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] GNRHR   D00989   Leuprolide   [5] 1, 2, 3, 51, 76 
 [1] HRH1   D00300   Diphenhydramine   [5] 49, 51, 70, 86, 256 
 D00669 
 D02419 
 D03285 
 D03360 
 D03854 
 [1] HTR4   D09205   Prucalopride   [3] 13, 51, 96 
 [1] NR3C1   D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 [2] OPRK1, OPRM1   D08639   Trimebutine   [1] 51 
 [1] PTGER1   D00180   Alprostadil   [2] 51, 70 
 D02705 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D09994   Selexipag   [5] 51, 70, 84, 86, 88 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 [1] TBXA2R   D01896   Cilostazol   [2] 51, 70 
 D04500   Ifetroban   [3] 51, 86, 113 
 123  Neurotrophin signaling pathway 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 124  NF-kappa B signaling pathway 
 4 genes, 7 drugs (DrugBank), 42 diseases shown 		  [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 125  NOD-like receptor signaling pathway 
 6 genes, 5 drugs (DrugBank), 28 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 126  Non-alcoholic fatty liver disease (NAFLD) 
 6 genes, 6 drugs (DrugBank), 36 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 127  Non-small cell lung cancer 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 128  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 129  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 130  Osteoclast differentiation 
 12 genes, 7 drugs (DrugBank), 46 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] TGFB1, TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 131  Ovarian steroidogenesis 
 1 gene, 2 drugs (DrugBank), 16 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 132  Oxidative phosphorylation 
 2 genes, 2 drugs (DrugBank), 16 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 D00724   Rabeprazole   [2] 2, 51 
 D08463 
 133  Oxytocin signaling pathway 
 14 genes, 6 drugs (DrugBank), 46 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 134  Pancreatic cancer 
 6 genes, 4 drugs (DrugBank), 42 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] JAK1   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 135  Parathyroid hormone synthesis, secretion and action 
 3 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 136  Parkinson disease 
 1 gene, 3 drugs (DrugBank), 6 diseases shown 		  [1] DRD2   D00702   Buspirone   [2] 6, 51 
 D07593 
 D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D01348   Terguride   [2] 51, 86 
 137  Pathogenic Escherichia coli infection 
 13 genes, 7 drugs (DrugBank), 36 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D09587   Brentuximab vedotin   [2] 49, 51 
 138  Pathways in cancer 
 26 genes, 20 drugs (DrugBank), 76 diseases shown 		  [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [4] ABL1, KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] CSF2RA   D05712   Regramostim   [4] 11, 46, 51, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [6] FGFR1, FGFR2, FGFR3, FLT4, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGER1   D00180   Alprostadil   [2] 51, 70 
 D02705 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 139  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 10 genes, 5 drugs (DrugBank), 54 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 140  Pertussis 
 5 genes, 4 drugs (DrugBank), 28 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 141  Phagosome 
 9 genes, 1 drug (DrugBank), 2 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D09587   Brentuximab vedotin   [2] 49, 51 
 142  Phospholipase D signaling pathway 
 5 genes, 5 drugs (DrugBank), 42 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 143  PI3K-Akt signaling pathway 
 18 genes, 11 drugs (DrugBank), 64 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PRL   D01348   Terguride   [2] 51, 86 
 144  Platelet activation 
 6 genes, 8 drugs (DrugBank), 21 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D09994   Selexipag   [5] 51, 70, 84, 86, 88 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 [1] PTGS1   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] TBXA2R   D01896   Cilostazol   [2] 51, 70 
 D04500   Ifetroban   [3] 51, 86, 113 
 145  Primary immunodeficiency 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 146  Prion diseases 
 3 genes, 3 drugs (DrugBank), 16 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 147  Progesterone-mediated oocyte maturation 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PDE3B   D01896   Cilostazol   [2] 51, 70 
 148  Prolactin signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PRL   D01348   Terguride   [2] 51, 86 
 149  Prostate cancer 
 6 genes, 5 drugs (DrugBank), 42 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [4] FGFR1, FGFR2, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 150  Proteasome 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] PSMB5   D03150   Bortezomib   [13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 151  Proteoglycans in cancer 
 7 genes, 7 drugs (DrugBank), 51 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] FGFR1, KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] TGFB1, TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 152  Purine metabolism 
 10 genes, 9 drugs (DrugBank), 52 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] PDE3A, PDE3B   D01896   Cilostazol   [2] 51, 70 
 [2] PDE4A, PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 153  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 154  Rap1 signaling pathway 
 11 genes, 7 drugs (DrugBank), 17 diseases shown 		  [1] DRD2   D00702   Buspirone   [2] 6, 51 
 D07593 
 D01745   Domperidone   [5] 6, 13, 17, 51, 230 
 D07868 
 D01348   Terguride   [2] 51, 86 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 155  Ras signaling pathway 
 11 genes, 4 drugs (DrugBank), 15 diseases shown 		  [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [4] ABL1, KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 156  Regulation of actin cytoskeleton 
 7 genes, 5 drugs (DrugBank), 18 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 157  Regulation of lipolysis in adipocytes 
 3 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] PDE3B   D01896   Cilostazol   [2] 51, 70 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 158  Relaxin signaling pathway 
 3 genes, 4 drugs (DrugBank), 15 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 159  Renal cell carcinoma 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 160  Renin secretion 
 15 genes, 7 drugs (DrugBank), 40 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [2] PDE3A, PDE3B   D01896   Cilostazol   [2] 51, 70 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 161  Retrograde endocannabinoid signaling 
 5 genes, 3 drugs (DrugBank), 19 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 162  Rheumatoid arthritis 
 12 genes, 8 drugs (DrugBank), 42 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 163  RIG-I-like receptor signaling pathway 
 1 gene, 3 drugs (DrugBank), 25 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 164  Salivary secretion 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 165  Salmonella infection 
 3 genes, 3 drugs (DrugBank), 16 diseases shown 		  [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 166  Serotonergic synapse 
 8 genes, 5 drugs (DrugBank), 20 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] HTR1A   D00702   Buspirone   [2] 6, 51 
 D07593 
 [1] HTR4   D09205   Prucalopride   [3] 13, 51, 96 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 167  Shigellosis 
 5 genes, 8 drugs (DrugBank), 57 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 168  Signaling pathways regulating pluripotency of stem cells 
 6 genes, 2 drugs (DrugBank), 12 diseases shown 		  [3] FGFR1, FGFR2, FGFR3   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 169  Small cell lung cancer 
 1 gene, 2 drugs (DrugBank), 16 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 170  Sphingolipid signaling pathway 
 1 gene, 3 drugs (DrugBank), 25 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 171  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 172  Synaptic vesicle cycle 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] SNAP25   D02735   Botulinum Toxin Type B   [3] 2, 6, 51 
 D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 173  Systemic lupus erythematosus 
 4 genes, 4 drugs (DrugBank), 37 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 174  T cell receptor signaling pathway 
 8 genes, 5 drugs (DrugBank), 44 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 175  Taste transduction 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] CACNA1C   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] HTR1A   D00702   Buspirone   [2] 6, 51 
 D07593 
 176  Terpenoid backbone biosynthesis 
 1 gene, 3 drugs (DrugBank), 29 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 177  TGF-beta signaling pathway 
 4 genes, 4 drugs (DrugBank), 26 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 178  Th1 and Th2 cell differentiation 
 9 genes, 2 drugs (DrugBank), 33 diseases shown 		  [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 179  Th17 cell differentiation 
 14 genes, 8 drugs (DrugBank), 63 diseases shown 		  [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 180  Thermogenesis 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 181  Thyroid hormone signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 182  Tight junction 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 183  TNF signaling pathway 
 5 genes, 6 drugs (DrugBank), 39 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 184  Toll-like receptor signaling pathway 
 5 genes, 5 drugs (DrugBank), 39 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 185  Toxoplasmosis 
 8 genes, 5 drugs (DrugBank), 27 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 186  Transcriptional misregulation in cancer 
 3 genes, 4 drugs (DrugBank), 32 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 187  Tuberculosis 
 15 genes, 7 drugs (DrugBank), 46 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 188  Type I diabetes mellitus 
 5 genes, 5 drugs (DrugBank), 39 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL1A, IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 189  Type II diabetes mellitus 
 4 genes, 5 drugs (DrugBank), 50 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 190  Ubiquitin mediated proteolysis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 191  Vascular smooth muscle contraction 
 9 genes, 8 drugs (DrugBank), 16 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D09994   Selexipag   [5] 51, 70, 84, 86, 88 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 192  VEGF signaling pathway 
 7 genes, 4 drugs (DrugBank), 40 diseases shown 		  [1] KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 193  Viral carcinogenesis 
 2 genes, 1 drug (DrugBank), 9 diseases shown 		  [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 194  Viral myocarditis 
 3 genes, 3 drugs (DrugBank), 34 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 195  Viral protein interaction with cytokine and cytokine receptor 
 6 genes, 5 drugs (DrugBank), 36 diseases shown 		  [4] CCL2, IL10, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 196  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 197  Yersinia infection 
 5 genes, 4 drugs (DrugBank), 28 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D06635   Rilonacept   [4] 51, 106, 107, 266 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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