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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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189 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adherens junction 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 3  Adipocytokine signaling pathway 
 2 genes, 3 drugs (DrugBank), 59 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  Adrenergic signaling in cardiomyocytes 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 5  African trypanosomiasis 
 3 genes, 3 drugs (DrugBank), 36 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 7  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 8  Alcoholism 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 9  Aldosterone synthesis and secretion 
 7 genes, 3 drugs (DrugBank), 17 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 10  Allograft rejection 
 5 genes, 4 drugs (DrugBank), 46 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Alzheimer disease 
 10 genes, 6 drugs (DrugBank), 68 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 12  Amoebiasis 
 5 genes, 4 drugs (DrugBank), 43 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Amphetamine addiction 
 7 genes, 4 drugs (DrugBank), 57 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 14  AMPK signaling pathway 
 3 genes, 3 drugs (DrugBank), 45 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 15  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 4 drugs (DrugBank), 67 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Antifolate resistance 
 3 genes, 3 drugs (DrugBank), 49 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 17  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 18  Apelin signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 19  Apoptosis 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 20  Arachidonic acid metabolism 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] PTGS1, PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 21  Arginine and proline metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] ODC1   D07883   Eflornithine   [1] 65 
 22  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 23  Asthma 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 24  Autoimmune thyroid disease 
 3 genes, 2 drugs (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] CTLA4   D06657   Tremelimumab   [2] 65, 96 
 25  Autophagy - animal 
 2 genes, 2 drugs (DrugBank), 40 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 26  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 27  Axon guidance 
 6 genes, 3 drugs (DrugBank), 55 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 28  B cell receptor signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 29  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 30  Breast cancer 
 4 genes, 3 drugs (DrugBank), 41 diseases shown 		  [2] ESR1, PGR   D00289   Danazol   [4] 60, 64, 65, 285 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 31  Butanoate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 32  C-type lectin receptor signaling pathway 
 10 genes, 6 drugs (DrugBank), 68 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 33  Calcium signaling pathway 
 16 genes, 8 drugs (DrugBank), 66 diseases shown 		  [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] HRH2   D00422   Ranitidine   [2] 13, 65 
 D00673 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 34  cAMP signaling pathway 
 6 genes, 3 drugs (DrugBank), 8 diseases shown 		  [2] ADORA1, ADORA2A   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 35  Carbohydrate digestion and absorption 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 36  Cardiac muscle contraction 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 37  Cell adhesion molecules (CAMs) 
 5 genes, 4 drugs (DrugBank), 25 diseases shown 		  [1] CD274   D10808   Durvalumab   [1] 65 
 [1] CD58   D02800   Alefacept   [6] 37, 60, 65, 164, 284, 285 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] CTLA4   D06657   Tremelimumab   [2] 65, 96 
 38  Cellular senescence 
 7 genes, 5 drugs (DrugBank), 73 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 39  Central carbon metabolism in cancer 
 2 genes, 2 drugs (DrugBank), 38 diseases shown 		  [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 40  cGMP-PKG signaling pathway 
 11 genes, 5 drugs (DrugBank), 57 diseases shown 		  [2] ADORA1, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 41  Chagas disease (American trypanosomiasis) 
 5 genes, 4 drugs (DrugBank), 41 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 42  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 43  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 44  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 45  Cholinergic synapse 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 46  Circadian entrainment 
 5 genes, 3 drugs (DrugBank), 17 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 47  Collecting duct acid secretion 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] ATP4A, ATP4B   D02593   Pantoprazole   [2] 13, 65 
 D05353 
 48  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 49  Cortisol synthesis and secretion 
 7 genes, 3 drugs (DrugBank), 17 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 50  Cushing syndrome 
 7 genes, 3 drugs (DrugBank), 17 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 51  Cytokine-cytokine receptor interaction 
 14 genes, 12 drugs (DrugBank), 65 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] GHR   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 52  Dilated cardiomyopathy (DCM) 
 5 genes, 4 drugs (DrugBank), 35 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 53  Dopaminergic synapse 
 5 genes, 4 drugs (DrugBank), 57 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 54  Drug metabolism - other enzymes 
 4 genes, 4 drugs (DrugBank), 39 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 55  EGFR tyrosine kinase inhibitor resistance 
 3 genes, 3 drugs (DrugBank), 42 diseases shown 		  [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 56  Endocrine and other factor-regulated calcium reabsorption 
 3 genes, 3 drugs (DrugBank), 22 diseases shown 		  [1] ESR1   D00289   Danazol   [4] 60, 64, 65, 285 
 [1] PTH1R   D06078   Teriparatide   [7] 46, 65, 68, 70, 71, 235, 274 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 57  Endocrine resistance 
 3 genes, 3 drugs (DrugBank), 41 diseases shown 		  [1] ESR1   D00289   Danazol   [4] 60, 64, 65, 285 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 58  Endocytosis 
 6 genes, 6 drugs (DrugBank), 22 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 59  Epstein-Barr virus infection 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] CD58   D02800   Alefacept   [6] 37, 60, 65, 164, 284, 285 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 60  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 61  Estrogen signaling pathway 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] ESR1, PGR   D00289   Danazol   [4] 60, 64, 65, 285 
 62  Fc epsilon RI signaling pathway 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 63  Fluid shear stress and atherosclerosis 
 3 genes, 3 drugs (DrugBank), 42 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 64  Focal adhesion 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 65  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 66  FoxO signaling pathway 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 67  GABAergic synapse 
 7 genes, 3 drugs (DrugBank), 17 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 68  Gastric acid secretion 
 3 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] ATP4A, ATP4B   D02593   Pantoprazole   [2] 13, 65 
 D05353 
 [1] HRH2   D00422   Ranitidine   [2] 13, 65 
 D00673 
 69  Gastric cancer 
 2 genes, 2 drugs (DrugBank), 38 diseases shown 		  [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 70  Glioma 
 2 genes, 2 drugs (DrugBank), 40 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 71  Glucagon signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 72  Glutamatergic synapse 
 7 genes, 4 drugs (DrugBank), 57 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 73  Glutathione metabolism 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] ODC1   D07883   Eflornithine   [1] 65 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 74  GnRH secretion 
 7 genes, 3 drugs (DrugBank), 17 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 75  GnRH signaling pathway 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 76  Graft-versus-host disease 
 3 genes, 3 drugs (DrugBank), 46 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 77  Growth hormone synthesis, secretion and action 
 6 genes, 4 drugs (DrugBank), 41 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [1] GHR   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 78  Hematopoietic cell lineage 
 6 genes, 9 drugs (DrugBank), 73 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 79  Hepatitis B 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 80  Hepatitis C 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 81  Hepatocellular carcinoma 
 2 genes, 2 drugs (DrugBank), 40 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 82  Herpes simplex virus 1 infection 
 6 genes, 5 drugs (DrugBank), 65 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 83  HIF-1 signaling pathway 
 7 genes, 4 drugs (DrugBank), 44 diseases shown 		  [3] EGLN1, EGLN2, EGLN3   D10593   Roxadustat   [1] 65 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 84  Human cytomegalovirus infection 
 10 genes, 8 drugs (DrugBank), 83 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 85  Human immunodeficiency virus 1 infection 
 8 genes, 6 drugs (DrugBank), 80 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 86  Human papillomavirus infection 
 3 genes, 4 drugs (DrugBank), 61 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  Human T-cell leukemia virus 1 infection 
 12 genes, 9 drugs (DrugBank), 74 diseases shown 		  [1] FDPS   D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 88  Huntington disease 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 89  Hypertrophic cardiomyopathy (HCM) 
 5 genes, 4 drugs (DrugBank), 35 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 90  IL-17 signaling pathway 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 91  Inflammatory bowel disease (IBD) 
 7 genes, 5 drugs (DrugBank), 41 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 93  Influenza A 
 6 genes, 5 drugs (DrugBank), 44 diseases shown 		  [1] FDPS   D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 94  Insulin resistance 
 2 genes, 3 drugs (DrugBank), 59 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 95  Insulin secretion 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 96  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 97  Intestinal immune network for IgA production 
 3 genes, 2 drugs (DrugBank), 25 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 98  JAK-STAT signaling pathway 
 11 genes, 9 drugs (DrugBank), 67 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] GHR   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 99  Kaposi sarcoma-associated herpesvirus infection 
 9 genes, 6 drugs (DrugBank), 79 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IFNGR1   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 100  Legionellosis 
 3 genes, 3 drugs (DrugBank), 36 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 101  Leishmaniasis 
 6 genes, 5 drugs (DrugBank), 42 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 102  Leukocyte transendothelial migration 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 103  Long-term depression 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 104  Long-term potentiation 
 6 genes, 4 drugs (DrugBank), 57 diseases shown 		  [1] CACNA1C   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 105  Longevity regulating pathway 
 3 genes, 3 drugs (DrugBank), 45 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 106  Longevity regulating pathway - multiple species 
 2 genes, 2 drugs (DrugBank), 40 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 107  Malaria 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] IL12A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 108  MAPK signaling pathway 
 16 genes, 10 drugs (DrugBank), 83 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 109  Measles 
 5 genes, 4 drugs (DrugBank), 23 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 110  Melanoma 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 111  Metabolic pathways 
 17 genes, 11 drugs (DrugBank), 63 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] ADA   D11017   Elapegademase   [1] 65 
 [2] ATP4A, ATP4B   D02593   Pantoprazole   [2] 13, 65 
 D05353 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] FDPS   D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] ODC1   D07883   Eflornithine   [1] 65 
 [2] PTGS1, PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 112  MicroRNAs in cancer 
 2 genes, 2 drugs (DrugBank), 39 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 113  Mineral absorption 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 114  Morphine addiction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 115  mTOR signaling pathway 
 3 genes, 4 drugs (DrugBank), 63 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 116  Natural killer cell mediated cytotoxicity 
 8 genes, 5 drugs (DrugBank), 68 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 117  Necroptosis 
 3 genes, 3 drugs (DrugBank), 39 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 118  Neuroactive ligand-receptor interaction 
 8 genes, 9 drugs (DrugBank), 68 diseases shown 		  [4] ADORA1, ADORA2A, ADORA2B, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] GHR   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] HRH2   D00422   Ranitidine   [2] 13, 65 
 D00673 
 [1] NR3C1   D00244   Betamethasone   [6] 2, 46, 65, 90, 96, 235 
 D00972 
 D01357 
 D01402 
 D01637 
 D02032 
 D02286 
 D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 [1] PTH1R   D06078   Teriparatide   [7] 46, 65, 68, 70, 71, 235, 274 
 119  NF-kappa B signaling pathway 
 3 genes, 4 drugs (DrugBank), 43 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 120  NOD-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 121  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 122  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 123  Oocyte meiosis 
 8 genes, 4 drugs (DrugBank), 58 diseases shown 		  [2] AR, PGR   D00289   Danazol   [4] 60, 64, 65, 285 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 124  Osteoclast differentiation 
 10 genes, 7 drugs (DrugBank), 78 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 125  Ovarian steroidogenesis 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 126  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] ATP4A, ATP4B   D02593   Pantoprazole   [2] 13, 65 
 D05353 
 127  Oxytocin signaling pathway 
 10 genes, 5 drugs (DrugBank), 58 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 128  p53 signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 129  Pancreatic cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 130  Parathyroid hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 20 diseases shown 		  [1] PTH1R   D06078   Teriparatide   [7] 46, 65, 68, 70, 71, 235, 274 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 131  Parkinson disease 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADORA2A   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 132  Pathogenic Escherichia coli infection 
 2 genes, 3 drugs (DrugBank), 42 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 133  Pathways in cancer 
 20 genes, 15 drugs (DrugBank), 74 diseases shown 		  [2] AR, ESR1   D00289   Danazol   [4] 60, 64, 65, 285 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [3] EGLN1, EGLN2, EGLN3   D10593   Roxadustat   [1] 65 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 134  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 9 genes, 5 drugs (DrugBank), 73 diseases shown 		  [1] CD274   D10808   Durvalumab   [1] 65 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 135  Pertussis 
 4 genes, 3 drugs (DrugBank), 36 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 136  Phospholipase D signaling pathway 
 2 genes, 2 drugs (DrugBank), 40 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 137  PI3K-Akt signaling pathway 
 8 genes, 8 drugs (DrugBank), 59 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [2] GHR, IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 138  Platelet activation 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] PTGS1   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 139  Platinum drug resistance 
 2 genes, 1 drug (DrugBank), 11 diseases shown 		  [2] TOP2A, TOP2B   D00125   Etoposide   [11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 
 D04107 
 140  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 141  Primary immunodeficiency 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [1] ADA   D11017   Elapegademase   [1] 65 
 [1] IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 142  Progesterone-mediated oocyte maturation 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] PGR   D00289   Danazol   [4] 60, 64, 65, 285 
 143  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] ESR1   D00289   Danazol   [4] 60, 64, 65, 285 
 144  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 145  Prostate cancer 
 5 genes, 5 drugs (DrugBank), 52 diseases shown 		  [1] AR   D00289   Danazol   [4] 60, 64, 65, 285 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 146  Proteoglycans in cancer 
 5 genes, 6 drugs (DrugBank), 65 diseases shown 		  [1] ESR1   D00289   Danazol   [4] 60, 64, 65, 285 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 147  Purine metabolism 
 5 genes, 5 drugs (DrugBank), 39 diseases shown 		  [1] ADA   D11017   Elapegademase   [1] 65 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 148  Pyrimidine metabolism 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 149  Rap1 signaling pathway 
 4 genes, 3 drugs (DrugBank), 12 diseases shown 		  [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 150  Ras signaling pathway 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 151  Regulation of actin cytoskeleton 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 152  Regulation of lipolysis in adipocytes 
 3 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [2] PTGS1, PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 153  Renal cell carcinoma 
 3 genes, 1 drug (DrugBank), 1 disease shown 		  [3] EGLN1, EGLN2, EGLN3   D10593   Roxadustat   [1] 65 
 154  Renin secretion 
 10 genes, 5 drugs (DrugBank), 57 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 155  Retrograde endocannabinoid signaling 
 5 genes, 3 drugs (DrugBank), 9 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 156  Rheumatoid arthritis 
 5 genes, 5 drugs (DrugBank), 46 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] CTLA4   D06657   Tremelimumab   [2] 65, 96 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 157  RIG-I-like receptor signaling pathway 
 3 genes, 3 drugs (DrugBank), 36 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 158  Salmonella infection 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 159  Serotonergic synapse 
 6 genes, 3 drugs (DrugBank), 9 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [2] PTGS1, PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 160  Shigellosis 
 3 genes, 4 drugs (DrugBank), 64 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 161  Signaling pathways regulating pluripotency of stem cells 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] FGFR2   D05338   Palifermin   [4] 13, 38, 39, 65 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 162  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 163  Sphingolipid signaling pathway 
 4 genes, 4 drugs (DrugBank), 38 diseases shown 		  [2] ADORA1, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 164  Systemic lupus erythematosus 
 3 genes, 3 drugs (DrugBank), 46 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 165  T cell receptor signaling pathway 
 7 genes, 5 drugs (DrugBank), 67 diseases shown 		  [1] CTLA4   D06657   Tremelimumab   [2] 65, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 166  Taste transduction 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1C   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 167  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 168  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] FDPS   D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 169  TGF-beta signaling pathway 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 170  Th1 and Th2 cell differentiation 
 12 genes, 7 drugs (DrugBank), 60 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 171  Th17 cell differentiation 
 13 genes, 9 drugs (DrugBank), 80 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 172  Thermogenesis 
 2 genes, 2 drugs (DrugBank), 44 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 173  Thyroid cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 174  Thyroid hormone signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] ESR1   D00289   Danazol   [4] 60, 64, 65, 285 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 175  Tight junction 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 176  TNF signaling pathway 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 177  Toll-like receptor signaling pathway 
 5 genes, 4 drugs (DrugBank), 46 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 178  Toxoplasmosis 
 5 genes, 4 drugs (DrugBank), 41 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 179  Transcriptional misregulation in cancer 
 5 genes, 5 drugs (DrugBank), 41 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RB   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 180  Tuberculosis 
 12 genes, 7 drugs (DrugBank), 71 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 181  Type I diabetes mellitus 
 7 genes, 5 drugs (DrugBank), 56 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 182  Type II diabetes mellitus 
 5 genes, 6 drugs (DrugBank), 66 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 [1] CACNA1G   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 183  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 184  Vascular smooth muscle contraction 
 6 genes, 3 drugs (DrugBank), 8 diseases shown 		  [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01145   Azelnidipine   [1] 65 
 185  VEGF signaling pathway 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00126   Ibuprofen   [6] 13, 46, 65, 113, 271, 299 
 D01122 
 D04490 
 D06606 
 186  Viral myocarditis 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 187  Viral protein interaction with cytokine and cytokine receptor 
 5 genes, 6 drugs (DrugBank), 43 diseases shown 		  [1] CXCR4   D08971   Plerixafor   [4] 51, 65, 285, 299 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 188  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 189  Yersinia infection 
 1 gene, 2 drugs (DrugBank), 34 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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