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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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111 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adipocytokine signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 3  Adrenergic signaling in cardiomyocytes 
 3 genes, 6 drugs (DrugBank), 26 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 4  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 5 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 5  Aldosterone synthesis and secretion 
 2 genes, 6 drugs (DrugBank), 31 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 6  Alzheimer disease 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 7  Amphetamine addiction 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 8  AMPK signaling pathway 
 2 genes, 2 drugs (DrugBank), 45 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 9  Amyotrophic lateral sclerosis (ALS) 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 10  Apelin signaling pathway 
 2 genes, 6 drugs (DrugBank), 50 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 11  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 12  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 13  Axon guidance 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 14  B cell receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 15  Bile secretion 
 1 gene, 1 drug (DrugBank), 19 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 16  Breast cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 17  C-type lectin receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 18  Caffeine metabolism 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 19  Calcium signaling pathway 
 7 genes, 7 drugs (DrugBank), 43 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 20  cAMP signaling pathway 
 3 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 21  Cellular senescence 
 6 genes, 2 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 22  Central carbon metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 23  cGMP-PKG signaling pathway 
 8 genes, 8 drugs (DrugBank), 43 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 24  Chagas disease (American trypanosomiasis) 
 1 gene, 4 drugs (DrugBank), 9 diseases shown 		  [1] ACE   D01069   Cilazapril   [1] 66 
 D07699 
 D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 25  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 26  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 27  Cortisol synthesis and secretion 
 2 genes, 6 drugs (DrugBank), 31 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 28  Cushing syndrome 
 2 genes, 6 drugs (DrugBank), 31 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 29  Cytokine-cytokine receptor interaction 
 3 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 30  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 31  Dopaminergic synapse 
 3 genes, 1 drug (DrugBank), 30 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 32  Drug metabolism - other enzymes 
 3 genes, 4 drugs (DrugBank), 39 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 33  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 34  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] VDR   D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00930   Paricalcitol   [3] 19, 66, 218 
 35  Endocrine resistance 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 36  Endocytosis 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 37  Epstein-Barr virus infection 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 38  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 39  Fc epsilon RI signaling pathway 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 40  Fc gamma R-mediated phagocytosis 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 41  Fluid shear stress and atherosclerosis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 42  Gap junction 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 43  Gastric cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 44  Glioma 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 45  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 46  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 47  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 48  Hematopoietic cell lineage 
 2 genes, 2 drugs (DrugBank), 44 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 49  Hepatocellular carcinoma 
 2 genes, 2 drugs (DrugBank), 40 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 50  Herpes simplex virus 1 infection 
 2 genes, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 51  HIF-1 signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 52  Human cytomegalovirus infection 
 6 genes, 2 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 53  Human immunodeficiency virus 1 infection 
 6 genes, 2 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 54  Human papillomavirus infection 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 55  Human T-cell leukemia virus 1 infection 
 7 genes, 3 drugs (DrugBank), 32 diseases shown 		  [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 56  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 4 drugs (DrugBank), 9 diseases shown 		  [1] ACE   D01069   Cilazapril   [1] 66 
 D07699 
 D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 57  Influenza A 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 58  Insulin resistance 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 59  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 60  Intestinal immune network for IgA production 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 61  JAK-STAT signaling pathway 
 2 genes, 2 drugs (DrugBank), 39 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 62  Kaposi sarcoma-associated herpesvirus infection 
 7 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 63  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 64  Longevity regulating pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 65  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 66  MAPK signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 67  Measles 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 68  Metabolic pathways 
 10 genes, 9 drugs (DrugBank), 57 diseases shown 		  [1] DHODH   D00749   Leflunomide   [10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [2] PDE4A, PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 69  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 70  Mineral absorption 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] VDR   D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00930   Paricalcitol   [3] 19, 66, 218 
 71  Morphine addiction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 72  mTOR signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 73  Natural killer cell mediated cytotoxicity 
 6 genes, 2 drugs (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 74  Neuroactive ligand-receptor interaction 
 5 genes, 11 drugs (DrugBank), 71 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [1] NR3C1   D00246   Budesonide   [10] 66, 85, 93, 94, 95, 96, 97, 98, 228, 299 
 D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 75  NF-kappa B signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 76  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 77  Osteoclast differentiation 
 6 genes, 2 drugs (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 78  Oxytocin signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 79  Pancreatic cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 80  Parathyroid hormone synthesis, secretion and action 
 2 genes, 3 drugs (DrugBank), 12 diseases shown 		  [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [1] VDR   D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00930   Paricalcitol   [3] 19, 66, 218 
 81  Pathways in cancer 
 4 genes, 8 drugs (DrugBank), 55 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 82  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 6 genes, 2 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 83  Peroxisome 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 84  Phospholipase D signaling pathway 
 3 genes, 7 drugs (DrugBank), 50 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 85  PI3K-Akt signaling pathway 
 3 genes, 3 drugs (DrugBank), 39 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 86  Platelet activation 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 87  Prostate cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 88  Proteasome 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] PSMB5   D03150   Bortezomib   [13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 89  Proteoglycans in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 90  Purine metabolism 
 5 genes, 5 drugs (DrugBank), 39 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] PDE4A, PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 91  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] DHODH   D00749   Leflunomide   [10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 92  Regulation of lipolysis in adipocytes 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 93  Renin secretion 
 9 genes, 12 drugs (DrugBank), 44 diseases shown 		  [1] ACE   D01069   Cilazapril   [1] 66 
 D07699 
 D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] REN   D03208   Aliskiren   [3] 66, 167, 222 
 94  Renin-angiotensin system 
 4 genes, 10 drugs (DrugBank), 26 diseases shown 		  [1] ACE   D01069   Cilazapril   [1] 66 
 D07699 
 D00621   Enalapril   [4] 19, 46, 66, 113 
 D07892 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 [1] REN   D03208   Aliskiren   [3] 66, 167, 222 
 95  Rheumatoid arthritis 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 96  Salivary secretion 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 97  Shigellosis 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 98  T cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 99  Terpenoid backbone biosynthesis 
 2 genes, 2 drugs (DrugBank), 24 diseases shown 		  [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 100  Th1 and Th2 cell differentiation 
 6 genes, 2 drugs (DrugBank), 30 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 101  Th17 cell differentiation 
 7 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 102  Thermogenesis 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 103  Thyroid hormone signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 104  Tuberculosis 
 7 genes, 4 drugs (DrugBank), 35 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] VDR   D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00930   Paricalcitol   [3] 19, 66, 218 
 105  Type II diabetes mellitus 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 106  Ubiquinone and other terpenoid-quinone biosynthesis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 107  Vascular smooth muscle contraction 
 1 gene, 5 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 108  VEGF signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 109  Viral carcinogenesis 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 110  Viral protein interaction with cytokine and cytokine receptor 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 111  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 

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