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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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14 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 2  AMPK signaling pathway 
 1 gene, 6 drugs (DrugBank), 36 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   [3] 79, 218, 222 
 D07983 
 D00359   Lovastatin   [10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 3  Bile secretion 
 1 gene, 6 drugs (DrugBank), 36 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   [3] 79, 218, 222 
 D07983 
 D00359   Lovastatin   [10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 4  cAMP signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 5  Cholesterol metabolism 
 1 gene, 2 drugs (DrugBank), 2 diseases shown 		  [1] PCSK9   D10335   Alirocumab   [1] 79 
 D10557   Evolocumab   [2] 79, 222 
 6  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] SERPINC1   D07510   Heparin   [11] 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 
 7  Fat digestion and absorption 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [1] MTTP   D09637   Lomitapide   [1] 79 
 [1] NPC1L1   D01966   Ezetimibe   [4] 49, 79, 93, 260 
 8  Glucagon signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 9  Hepatitis C 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 10  Insulin resistance 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 11  Metabolic pathways 
 1 gene, 6 drugs (DrugBank), 36 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   [3] 79, 218, 222 
 D07983 
 D00359   Lovastatin   [10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 12  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 13  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 14  Terpenoid backbone biosynthesis 
 1 gene, 6 drugs (DrugBank), 36 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   [3] 79, 218, 222 
 D07983 
 D00359   Lovastatin   [10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 

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