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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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146 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] KIT   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 2  Adipocytokine signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 3  Adrenergic signaling in cardiomyocytes 
 12 genes, 4 drugs (DrugBank), 4 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 [1] SCN5A   D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 4  AGE-RAGE signaling pathway in diabetic complications 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 5  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 6  Alcoholism 
 8 genes, 12 drugs (DrugBank), 18 diseases shown 		  [1] DRD2   D00136   Haloperidol   [1] 8 
 D01898 
 D00454   Olanzapine   [2] 2, 8 
 D06623 
 D09953   Pridopidine   [2] 6, 8 
 D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] SLC18A2   D08575   Tetrabenazine   [1] 8 
 D10675   Valbenazine   [1] 8 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 7  Aldosterone synthesis and secretion 
 7 genes, 2 drugs (DrugBank), 15 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 8  Aldosterone-regulated sodium reabsorption 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 9  Alzheimer disease 
 5 genes, 5 drugs (DrugBank), 16 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 10  Amphetamine addiction 
 11 genes, 8 drugs (DrugBank), 16 diseases shown 		  [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] SLC18A2   D08575   Tetrabenazine   [1] 8 
 D10675   Valbenazine   [1] 8 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 11  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ADRA1A   D00454   Olanzapine   [2] 2, 8 
 D06623 
 12  Amyotrophic lateral sclerosis (ALS) 
 11 genes, 6 drugs (DrugBank), 16 diseases shown 		  [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 13  Axon guidance 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] ABL1   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] SEMA4D   D11469   Pepinemab   [2] 8, 13 
 14  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 15  Bile secretion 
 5 genes, 2 drugs (DrugBank), 13 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 [1] NR1H4   D00734   Ursodeoxycholic acid   [12] 6, 8, 20, 67, 84, 93, 94, 95, 96, 97, 234, 299 
 16  Breast cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] KIT   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 17  Butanoate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 18  C-type lectin receptor signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 19  Calcium signaling pathway 
 17 genes, 9 drugs (DrugBank), 30 diseases shown 		  [8] ADRA1A, ADRA1B, ADRA1D, HRH1, HTR2A, HTR2B, HTR2C, HTR6   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 20  cAMP signaling pathway 
 20 genes, 12 drugs (DrugBank), 22 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 [1] DRD2   D00136   Haloperidol   [1] 8 
 D01898 
 D09953   Pridopidine   [2] 6, 8 
 D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [2] DRD2, HTR6   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 21  Carbohydrate digestion and absorption 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 22  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 23  Cell cycle 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ABL1   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 24  Cellular senescence 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 25  Central carbon metabolism in cancer 
 3 genes, 1 drug (DrugBank), 5 diseases shown 		  [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 26  cGMP-PKG signaling pathway 
 10 genes, 3 drugs (DrugBank), 3 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [3] ADRA2A, ADRA2B, ADRA2C   D08482   Rilmenidine   [1] 8 
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 27  Chagas disease (American trypanosomiasis) 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 28  Choline metabolism in cancer 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 29  Cholinergic synapse 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] ACHE   D09917   Latrepirdine   [1] 8 
 30  Chronic myeloid leukemia 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ABL1   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 31  Circadian entrainment 
 14 genes, 7 drugs (DrugBank), 26 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [2] MTNR1A, MTNR1B   D02689   Ramelteon   [3] 6, 8, 46 
 32  Cocaine addiction 
 9 genes, 12 drugs (DrugBank), 18 diseases shown 		  [1] DRD2   D00136   Haloperidol   [1] 8 
 D01898 
 D00454   Olanzapine   [2] 2, 8 
 D06623 
 D09953   Pridopidine   [2] 6, 8 
 D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] SLC18A2   D08575   Tetrabenazine   [1] 8 
 D10675   Valbenazine   [1] 8 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 33  Collecting duct acid secretion 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 34  Cortisol synthesis and secretion 
 4 genes, 2 drugs (DrugBank), 16 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 35  Cushing syndrome 
 4 genes, 2 drugs (DrugBank), 16 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 36  Dopaminergic synapse 
 16 genes, 14 drugs (DrugBank), 18 diseases shown 		  [1] DRD2   D00136   Haloperidol   [1] 8 
 D01898 
 D09953   Pridopidine   [2] 6, 8 
 D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [3] DRD2, DRD3, DRD4   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [2] GRIN2A, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 [1] SCN1A   D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 [1] SLC18A2   D08575   Tetrabenazine   [1] 8 
 D10675   Valbenazine   [1] 8 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 37  EGFR tyrosine kinase inhibitor resistance 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 38  Endocrine and other factor-regulated calcium reabsorption 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 39  Endocrine resistance 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 40  Endocytosis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PDGFRA   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 41  Epithelial cell signaling in Helicobacter pylori infection 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 42  Epstein-Barr virus infection 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 43  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ABL1   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 44  Fc epsilon RI signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 45  Fluid shear stress and atherosclerosis 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 46  Focal adhesion 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 47  FoxO signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 48  GABAergic synapse 
 19 genes, 2 drugs (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00225   Alprazolam   [1] 8 
 49  Gap junction 
 6 genes, 5 drugs (DrugBank), 10 diseases shown 		  [1] DRD2   D00136   Haloperidol   [1] 8 
 D01898 
 D09953   Pridopidine   [2] 6, 8 
 [2] DRD2, HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [4] DRD2, HTR2A, HTR2B, HTR2C   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 50  Gastric acid secretion 
 6 genes, 2 drugs (DrugBank), 15 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 51  Glioma 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 52  Glucagon signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 53  Glutamatergic synapse 
 14 genes, 5 drugs (DrugBank), 16 diseases shown 		  [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 54  Glycerophospholipid metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] ACHE   D09917   Latrepirdine   [1] 8 
 55  GnRH secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 56  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 57  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 58  Hematopoietic cell lineage 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] KIT   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 59  Hepatitis B 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 60  Hepatitis C 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 61  Hepatocellular carcinoma 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 62  Human cytomegalovirus infection 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 [1] PDGFRA   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 63  Human immunodeficiency virus 1 infection 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 64  Human papillomavirus infection 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 65  Huntington disease 
 2 genes, 5 drugs (DrugBank), 16 diseases shown 		  [2] GRIN1, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 66  IL-17 signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 67  Inflammatory mediator regulation of TRP channels 
 8 genes, 3 drugs (DrugBank), 6 diseases shown 		  [4] HRH1, HTR2A, HTR2B, HTR2C   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 68  Insulin resistance 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 69  Insulin secretion 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 70  JAK-STAT signaling pathway 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 71  Kaposi sarcoma-associated herpesvirus infection 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 72  Leishmaniasis 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 73  Leukocyte transendothelial migration 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 74  Long-term depression 
 3 genes, 1 drug (DrugBank), 7 diseases shown 		  [3] GRIA1, GRIA2, GRIA3   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 75  Long-term potentiation 
 7 genes, 5 drugs (DrugBank), 16 diseases shown 		  [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 76  MAPK signaling pathway 
 10 genes, 3 drugs (DrugBank), 17 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 77  Melanogenesis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] KIT   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 78  Melanoma 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 79  Metabolic pathways 
 13 genes, 5 drugs (DrugBank), 33 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 80  MicroRNAs in cancer 
 3 genes, 1 drug (DrugBank), 5 diseases shown 		  [3] ABL1, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 81  Mineral absorption 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 82  Morphine addiction 
 20 genes, 2 drugs (DrugBank), 2 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00225   Alprazolam   [1] 8 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 83  Neuroactive ligand-receptor interaction 
 46 genes, 12 drugs (DrugBank), 18 diseases shown 		  [11] ADRA1A, ADRA1B, ADRA1D, DRD2, DRD3, DRD4, HRH1, HTR2A, HTR2B, HTR2C, HTR6   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [3] ADRA2A, ADRA2B, ADRA2C   D08482   Rilmenidine   [1] 8 
 [1] DRD2   D00136   Haloperidol   [1] 8 
 D01898 
 D09953   Pridopidine   [2] 6, 8 
 [2] DRD2, HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00225   Alprazolam   [1] 8 
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [2] MTNR1A, MTNR1B   D02689   Ramelteon   [3] 6, 8, 46 
 84  Neurotrophin signaling pathway 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] ABL1   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 85  Nicotine addiction 
 25 genes, 6 drugs (DrugBank), 16 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00225   Alprazolam   [1] 8 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 86  NOD-like receptor signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 87  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 88  Oocyte meiosis 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 89  Osteoclast differentiation 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 90  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 91  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 92  Pancreatic secretion 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 93  Parathyroid hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 94  Parkinson disease 
 3 genes, 7 drugs (DrugBank), 8 diseases shown 		  [1] DRD2   D00136   Haloperidol   [1] 8 
 D01898 
 D00454   Olanzapine   [2] 2, 8 
 D06623 
 D09953   Pridopidine   [2] 6, 8 
 D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [1] SLC18A2   D08575   Tetrabenazine   [1] 8 
 D10675   Valbenazine   [1] 8 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 95  Pathogenic Escherichia coli infection 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] ABL1   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 96  Pathways in cancer 
 5 genes, 2 drugs (DrugBank), 13 diseases shown 		  [4] ABL1, KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 97  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 98  Pertussis 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 99  Phospholipase D signaling pathway 
 3 genes, 1 drug (DrugBank), 5 diseases shown 		  [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 100  PI3K-Akt signaling pathway 
 3 genes, 1 drug (DrugBank), 5 diseases shown 		  [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 101  Platelet activation 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 102  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARA   D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 103  Progesterone-mediated oocyte maturation 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 104  Prolactin signaling pathway 
 5 genes, 2 drugs (DrugBank), 3 diseases shown 		  [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 105  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 106  Prostate cancer 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 107  Protein digestion and absorption 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 108  Proteoglycans in cancer 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 109  Proximal tubule bicarbonate reclamation 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 110  Purine metabolism 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] PDE4A, PDE4B, PDE4C, PDE4D   D01783   Rolipram   [2] 8, 13 
 111  Rap1 signaling pathway 
 11 genes, 11 drugs (DrugBank), 21 diseases shown 		  [1] DRD2   D00136   Haloperidol   [1] 8 
 D01898 
 D00454   Olanzapine   [2] 2, 8 
 D06623 
 D09953   Pridopidine   [2] 6, 8 
 D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [3] GRIN1, GRIN2A, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [3] KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 112  Ras signaling pathway 
 7 genes, 6 drugs (DrugBank), 19 diseases shown 		  [4] ABL1, KIT, PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [3] GRIN1, GRIN2A, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 113  Regulation of actin cytoskeleton 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PDGFRA, PDGFRB   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 114  Relaxin signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 115  Retrograde endocannabinoid signaling 
 24 genes, 3 drugs (DrugBank), 7 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00225   Alprazolam   [1] 8 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 116  RIG-I-like receptor signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 117  Salivary secretion 
 7 genes, 2 drugs (DrugBank), 3 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 118  Salmonella infection 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 119  Serotonergic synapse 
 9 genes, 7 drugs (DrugBank), 9 diseases shown 		  [3] GABRB1, GABRB2, GABRB3   D00225   Alprazolam   [1] 8 
 [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [4] HTR2A, HTR2B, HTR2C, HTR6   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] SLC18A2   D08575   Tetrabenazine   [1] 8 
 D10675   Valbenazine   [1] 8 
 [1] SLC6A4   D00822   Citalopram   [3] 8, 46, 127 
 D07704 
 D00825   Sertraline   [3] 6, 8, 206 
 D02360 
 120  Shigellosis 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] ABL1   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 121  Signaling pathways regulating pluripotency of stem cells 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 122  Sphingolipid signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 123  Steroid hormone biosynthesis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] CYP17A1   D00351   Ketoconazole   [3] 8, 13, 75 
 124  Synaptic vesicle cycle 
 4 genes, 6 drugs (DrugBank), 7 diseases shown 		  [1] SLC18A2   D08575   Tetrabenazine   [1] 8 
 D10675   Valbenazine   [1] 8 
 [1] SLC6A2   D02574   Atomoxetine   [3] 6, 8, 13 
 D07473 
 [2] SLC6A2, SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 [1] SLC6A4   D00822   Citalopram   [3] 8, 46, 127 
 D07704 
 D00825   Sertraline   [3] 6, 8, 206 
 D02360 
 125  Systemic lupus erythematosus 
 2 genes, 5 drugs (DrugBank), 16 diseases shown 		  [2] GRIN2A, GRIN2B   D00777   Amantadine   [4] 6, 8, 13, 127 
 D07441 
 D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D09917   Latrepirdine   [1] 8 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 126  T cell receptor signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 127  Taste transduction 
 9 genes, 2 drugs (DrugBank), 3 diseases shown 		  [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D00225   Alprazolam   [1] 8 
 [3] SCN2A, SCN3A, SCN9A   D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 128  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 129  Th1 and Th2 cell differentiation 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 130  Th17 cell differentiation 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 131  Thermogenesis 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 132  Thyroid hormone signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 133  Thyroid hormone synthesis 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4   D00298   Digoxin   [2] 8, 46 
 134  TNF signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 135  Toll-like receptor signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 136  Toxoplasmosis 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 137  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] GRIA3   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 138  Tuberculosis 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 139  Type I diabetes mellitus 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 140  Type II diabetes mellitus 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] CACNA1G   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 141  Ubiquinone and other terpenoid-quinone biosynthesis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 142  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 143  Vascular smooth muscle contraction 
 3 genes, 1 drug (DrugBank), 2 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00454   Olanzapine   [2] 2, 8 
 D06623 
 144  VEGF signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 
 145  Viral myocarditis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ABL1   D08953   Nilotinib   [5] 6, 8, 34, 51, 86 
 146  Yersinia infection 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D10959   Neflamapimod   [1] 8 

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