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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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63 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 2  Adrenergic signaling in cardiomyocytes 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 3  Aldosterone synthesis and secretion 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 4  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] NR3C2   D00986   Fludrocortisone   [3] 6, 17, 81 
 D07967 
 5  Alzheimer disease 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 6  Amphetamine addiction 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] CACNA1C, CACNA1D   D00437   Nifedipine   [2] 50, 81 
 7  AMPK signaling pathway 
 3 genes, 2 drugs (DrugBank), 25 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 8  Apelin signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 9  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 10  Autophagy - animal 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 11  Calcium signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 12  cAMP signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 13  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CACNA1D   D00437   Nifedipine   [2] 50, 81 
 14  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 15  Cellular senescence 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CACNA1D   D00437   Nifedipine   [2] 50, 81 
 16  cGMP-PKG signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 17  Cholinergic synapse 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 18  Circadian entrainment 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] CACNA1C, CACNA1D   D00437   Nifedipine   [2] 50, 81 
 19  Circadian rhythm 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 20  Cortisol synthesis and secretion 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 21  Cushing syndrome 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 22  Dilated cardiomyopathy (DCM) 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 23  Dopaminergic synapse 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] CACNA1C, CACNA1D   D00437   Nifedipine   [2] 50, 81 
 24  Fluid shear stress and atherosclerosis 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 25  FoxO signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 26  GABAergic synapse 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 27  Glucagon signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 28  Glutamatergic synapse 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] CACNA1C, CACNA1D   D00437   Nifedipine   [2] 50, 81 
 29  GnRH secretion 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 30  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 31  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 32  Huntington disease 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 33  Hypertrophic cardiomyopathy (HCM) 
 6 genes, 2 drugs (DrugBank), 18 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 34  Insulin resistance 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 35  Insulin secretion 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 36  Insulin signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 37  Long-term potentiation 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CACNA1C   D00437   Nifedipine   [2] 50, 81 
 38  Longevity regulating pathway 
 3 genes, 2 drugs (DrugBank), 25 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 39  Longevity regulating pathway - multiple species 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 40  MAPK signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 41  Metabolic pathways 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CYP19A1   D00964   Letrozole   [2] 81, 89 
 42  mTOR signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 43  Neuroactive ligand-receptor interaction 
 1 gene, 9 drugs (DrugBank), 61 diseases shown 		  [1] NR3C1   D07749   Cortisone   [1] 81 
 D00973   Cortisone acetate   [1] 81 
 D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00088   Hydrocortisone   [8] 6, 53, 75, 78, 81, 83, 97, 299 
 D00165   Hydrocortisone acetate   [8] 6, 53, 75, 78, 81, 83, 97, 299 
 D00976   Hydrocortisone cypionate   [2] 81, 83 
 D01442   Hydrocortisone succinate   [3] 6, 81, 83 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 44  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 45  Oocyte meiosis 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] AR   D00586   Flutamide   [1] 81 
 46  Osteoclast differentiation 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 47  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CYP19A1   D00964   Letrozole   [2] 81, 89 
 48  Oxytocin signaling pathway 
 6 genes, 2 drugs (DrugBank), 18 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 49  Pathways in cancer 
 2 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] AR   D00586   Flutamide   [1] 81 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 50  PI3K-Akt signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 51  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 52  Prostate cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] AR   D00586   Flutamide   [1] 81 
 53  Renin secretion 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 54  Retrograde endocannabinoid signaling 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 55  Serotonergic synapse 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 
 56  Steroid hormone biosynthesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CYP19A1   D00964   Letrozole   [2] 81, 89 
 57  Taste transduction 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CACNA1C   D00437   Nifedipine   [2] 50, 81 
 58  Thermogenesis 
 3 genes, 2 drugs (DrugBank), 25 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 59  Thyroid cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 60  Tight junction 
 3 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] CACNA1D   D00437   Nifedipine   [2] 50, 81 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 61  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 62  Type II diabetes mellitus 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] CACNA1C, CACNA1D   D00437   Nifedipine   [2] 50, 81 
 63  Vascular smooth muscle contraction 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00437   Nifedipine   [2] 50, 81 

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