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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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138 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 2 genes, 6 drugs (DrugBank), 43 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 2  Adrenergic signaling in cardiomyocytes 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] SCN5A   D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 3  African trypanosomiasis 
 6 genes, 7 drugs (DrugBank), 49 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  AGE-RAGE signaling pathway in diabetic complications 
 6 genes, 7 drugs (DrugBank), 47 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 5  Alcoholism 
 1 gene, 2 drugs (DrugBank), 7 diseases shown 		  [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 6  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank), 12 diseases shown 		  [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 7  Allograft rejection 
 6 genes, 7 drugs (DrugBank), 52 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 8  Alzheimer disease 
 2 genes, 6 drugs (DrugBank), 47 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  Amoebiasis 
 8 genes, 8 drugs (DrugBank), 52 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Amphetamine addiction 
 1 gene, 2 drugs (DrugBank), 7 diseases shown 		  [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 11  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 12  Amyotrophic lateral sclerosis (ALS) 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Antifolate resistance 
 5 genes, 7 drugs (DrugBank), 60 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 14  Antigen processing and presentation 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Apoptosis 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Asthma 
 2 genes, 5 drugs (DrugBank), 42 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 17  Autoimmune thyroid disease 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 18  Bile secretion 
 2 genes, 2 drugs (DrugBank), 25 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 [1] NR1H4   D00734   Ursodeoxycholic acid   [12] 6, 8, 20, 67, 84, 93, 94, 95, 96, 97, 234, 299 
 19  C-type lectin receptor signaling pathway 
 7 genes, 7 drugs (DrugBank), 49 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 20  Calcium signaling pathway 
 3 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] CHRNA7   D03365   Nicotine   [2] 6, 84 
 D05156 
 D05157 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 21  cAMP signaling pathway 
 7 genes, 5 drugs (DrugBank), 25 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D05744   Roflumilast   [2] 84, 299 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 22  Cell adhesion molecules (CAMs) 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 23  Cellular senescence 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL1A, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 24  cGMP-PKG signaling pathway 
 6 genes, 4 drugs (DrugBank), 15 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PDE5A   D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 25  Chagas disease (American trypanosomiasis) 
 7 genes, 7 drugs (DrugBank), 49 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 26  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CHRNA7   D03365   Nicotine   [2] 6, 84 
 D05156 
 D05157 
 27  Chemokine signaling pathway 
 4 genes, 3 drugs (DrugBank), 15 diseases shown 		  [1] CCL2   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 [2] JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 28  Cholinergic synapse 
 7 genes, 2 drugs (DrugBank), 10 diseases shown 		  [6] CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4   D03365   Nicotine   [2] 6, 84 
 D05156 
 D05157 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 29  Circadian entrainment 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 30  Cocaine addiction 
 1 gene, 2 drugs (DrugBank), 7 diseases shown 		  [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 31  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] SERPINC1   D07510   Heparin   [11] 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 
 32  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank), 12 diseases shown 		  [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 33  Cushing syndrome 
 1 gene, 1 drug (DrugBank), 12 diseases shown 		  [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 34  Cytokine-cytokine receptor interaction 
 13 genes, 10 drugs (DrugBank), 52 diseases shown 		  [6] CCL2, IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 35  Cytosolic DNA-sensing pathway 
 2 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 36  Dilated cardiomyopathy (DCM) 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 37  Dopaminergic synapse 
 2 genes, 3 drugs (DrugBank), 14 diseases shown 		  [1] SCN1A   D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 38  Drug metabolism - other enzymes 
 2 genes, 1 drug (DrugBank), 34 diseases shown 		  [2] IMPDH1, IMPDH2   D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 39  EGFR tyrosine kinase inhibitor resistance 
 4 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 40  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] VDR   D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 41  Endocytosis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 42  Epstein-Barr virus infection 
 5 genes, 6 drugs (DrugBank), 43 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 43  Fc epsilon RI signaling pathway 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 44  Fluid shear stress and atherosclerosis 
 6 genes, 7 drugs (DrugBank), 51 diseases shown 		  [4] CCL2, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 45  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 46  FoxO signaling pathway 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 47  GABAergic synapse 
 16 genes, 1 drug (DrugBank), 8 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00549   Propofol   [8] 6, 21, 22, 34, 46, 84, 98, 296 
 48  Gap junction 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 49  Gastric acid secretion 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 50  Graft-versus-host disease 
 6 genes, 7 drugs (DrugBank), 56 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 51  Growth hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 15 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 52  Hematopoietic cell lineage 
 8 genes, 9 drugs (DrugBank), 72 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 53  Hepatitis B 
 6 genes, 6 drugs (DrugBank), 43 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 54  Hepatitis C 
 3 genes, 6 drugs (DrugBank), 43 diseases shown 		  [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 55  Herpes simplex virus 1 infection 
 9 genes, 8 drugs (DrugBank), 49 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 56  HIF-1 signaling pathway 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 57  Human cytomegalovirus infection 
 8 genes, 10 drugs (DrugBank), 51 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [1] JAK1   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 58  Human immunodeficiency virus 1 infection 
 2 genes, 6 drugs (DrugBank), 42 diseases shown 		  [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 59  Human papillomavirus infection 
 3 genes, 6 drugs (DrugBank), 43 diseases shown 		  [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 60  Human T-cell leukemia virus 1 infection 
 6 genes, 7 drugs (DrugBank), 49 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 61  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 5 drugs (DrugBank), 42 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 62  IL-17 signaling pathway 
 4 genes, 6 drugs (DrugBank), 47 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 63  Inflammatory bowel disease (IBD) 
 8 genes, 7 drugs (DrugBank), 49 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 64  Inflammatory mediator regulation of TRP channels 
 2 genes, 3 drugs (DrugBank), 27 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 65  Influenza A 
 10 genes, 8 drugs (DrugBank), 49 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 66  Insulin resistance 
 2 genes, 5 drugs (DrugBank), 42 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 67  Intestinal immune network for IgA production 
 4 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 68  JAK-STAT signaling pathway 
 10 genes, 4 drugs (DrugBank), 24 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 69  Kaposi sarcoma-associated herpesvirus infection 
 6 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 70  Legionellosis 
 5 genes, 7 drugs (DrugBank), 49 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 71  Leishmaniasis 
 8 genes, 8 drugs (DrugBank), 49 diseases shown 		  [4] IL10, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 72  Long-term depression 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 73  Malaria 
 6 genes, 7 drugs (DrugBank), 49 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL12A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 74  MAPK signaling pathway 
 4 genes, 7 drugs (DrugBank), 51 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 75  Measles 
 8 genes, 4 drugs (DrugBank), 28 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 76  Melanogenesis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 77  Metabolic pathways 
 13 genes, 6 drugs (DrugBank), 60 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 [2] IMPDH1, IMPDH2   D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D05744   Roflumilast   [2] 84, 299 
 [1] PDE5A   D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 78  Mineral absorption 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] VDR   D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 79  Morphine addiction 
 20 genes, 2 drugs (DrugBank), 9 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00549   Propofol   [8] 6, 21, 22, 34, 46, 84, 98, 296 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D05744   Roflumilast   [2] 84, 299 
 80  mTOR signaling pathway 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 81  Natural killer cell mediated cytotoxicity 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 82  Necroptosis 
 7 genes, 7 drugs (DrugBank), 47 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 83  Neuroactive ligand-receptor interaction 
 38 genes, 14 drugs (DrugBank), 74 diseases shown 		  [16] CHRNA1, CHRNA10, CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNB1, CHRNB2, CHRNB3, CHRNB4, CHRND, CHRNE, CHRNG   D03365   Nicotine   [2] 6, 84 
 D05156 
 D05157 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00549   Propofol   [8] 6, 21, 22, 34, 46, 84, 98, 296 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [1] NR3C1   D01703   Ciclesonide   [1] 84 
 D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D09994   Selexipag   [5] 51, 70, 84, 86, 88 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 84  NF-kappa B signaling pathway 
 3 genes, 7 drugs (DrugBank), 51 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 85  Nicotine addiction 
 20 genes, 2 drugs (DrugBank), 8 diseases shown 		  [4] CHRNA4, CHRNA6, CHRNA7, CHRNB2   D03365   Nicotine   [2] 6, 84 
 D05156 
 D05157 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00549   Propofol   [8] 6, 21, 22, 34, 46, 84, 98, 296 
 86  NOD-like receptor signaling pathway 
 6 genes, 7 drugs (DrugBank), 47 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  Non-alcoholic fatty liver disease (NAFLD) 
 5 genes, 7 drugs (DrugBank), 47 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 88  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 89  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 90  Osteoclast differentiation 
 6 genes, 8 drugs (DrugBank), 51 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 91  Oxytocin signaling pathway 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 92  Pancreatic cancer 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK1   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 93  Parathyroid hormone synthesis, secretion and action 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [4] PDE4A, PDE4B, PDE4C, PDE4D   D05744   Roflumilast   [2] 84, 299 
 [1] VDR   D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 94  Parkinson disease 
 1 gene, 2 drugs (DrugBank), 7 diseases shown 		  [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 95  Pathogenic Escherichia coli infection 
 4 genes, 7 drugs (DrugBank), 51 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 96  Pathways in cancer 
 10 genes, 6 drugs (DrugBank), 29 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 97  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 2 genes, 1 drug (DrugBank), 9 diseases shown 		  [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 98  Pertussis 
 8 genes, 7 drugs (DrugBank), 49 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 99  PI3K-Akt signaling pathway 
 5 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 100  Platelet activation 
 4 genes, 4 drugs (DrugBank), 8 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D09994   Selexipag   [5] 51, 70, 84, 86, 88 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 101  Primary immunodeficiency 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 102  Prion diseases 
 3 genes, 2 drugs (DrugBank), 17 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 103  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 104  Prostate cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 105  Proteoglycans in cancer 
 2 genes, 6 drugs (DrugBank), 44 diseases shown 		  [1] IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 106  Purine metabolism 
 10 genes, 4 drugs (DrugBank), 41 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [2] IMPDH1, IMPDH2   D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D05744   Roflumilast   [2] 84, 299 
 [1] PDE5A   D02008   Tadalafil   [6] 6, 51, 75, 84, 86, 113 
 107  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 108  Renin secretion 
 4 genes, 3 drugs (DrugBank), 12 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 109  Retrograde endocannabinoid signaling 
 16 genes, 1 drug (DrugBank), 8 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00549   Propofol   [8] 6, 21, 22, 34, 46, 84, 98, 296 
 110  Rheumatoid arthritis 
 8 genes, 8 drugs (DrugBank), 56 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 111  RIG-I-like receptor signaling pathway 
 3 genes, 6 drugs (DrugBank), 44 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 112  Salivary secretion 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 113  Salmonella infection 
 3 genes, 2 drugs (DrugBank), 17 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 114  Serotonergic synapse 
 3 genes, 1 drug (DrugBank), 8 diseases shown 		  [3] GABRB1, GABRB2, GABRB3   D00549   Propofol   [8] 6, 21, 22, 34, 46, 84, 98, 296 
 115  Shigellosis 
 3 genes, 7 drugs (DrugBank), 51 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 116  Signaling pathways regulating pluripotency of stem cells 
 3 genes, 1 drug (DrugBank), 9 diseases shown 		  [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 117  Sphingolipid signaling pathway 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 118  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 119  Synaptic vesicle cycle 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] SLC6A2, SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 [1] SLC6A3   D03215   Armodafinil   [3] 6, 13, 84 
 120  Systemic lupus erythematosus 
 4 genes, 6 drugs (DrugBank), 52 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 121  T cell receptor signaling pathway 
 2 genes, 5 drugs (DrugBank), 42 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 122  Taste transduction 
 9 genes, 2 drugs (DrugBank), 15 diseases shown 		  [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D00549   Propofol   [8] 6, 21, 22, 34, 46, 84, 98, 296 
 [3] SCN2A, SCN3A, SCN9A   D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 123  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 124  TGF-beta signaling pathway 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 125  Th1 and Th2 cell differentiation 
 6 genes, 2 drugs (DrugBank), 18 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 126  Th17 cell differentiation 
 9 genes, 6 drugs (DrugBank), 33 diseases shown 		  [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 127  TNF signaling pathway 
 4 genes, 6 drugs (DrugBank), 47 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 128  Toll-like receptor signaling pathway 
 7 genes, 8 drugs (DrugBank), 56 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 129  Toxoplasmosis 
 8 genes, 8 drugs (DrugBank), 45 diseases shown 		  [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 130  Transcriptional misregulation in cancer 
 3 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 131  Tuberculosis 
 11 genes, 9 drugs (DrugBank), 50 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VDR   D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 132  Type I diabetes mellitus 
 7 genes, 8 drugs (DrugBank), 56 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 133  Type II diabetes mellitus 
 1 gene, 5 drugs (DrugBank), 42 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 134  Vascular smooth muscle contraction 
 5 genes, 6 drugs (DrugBank), 13 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [3] GUCY1A1, GUCY1A2, GUCY1B1   D09572   Riociguat   [6] 51, 84, 86, 88, 225, 299 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D09994   Selexipag   [5] 51, 70, 84, 86, 88 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 135  Viral carcinogenesis 
 3 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 136  Viral myocarditis 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 137  Viral protein interaction with cytokine and cytokine receptor 
 6 genes, 7 drugs (DrugBank), 43 diseases shown 		  [4] CCL2, IL10, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CCR5   D06670   Maraviroc   [2] 46, 84 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 138  Yersinia infection 
 5 genes, 6 drugs (DrugBank), 47 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL1B   D09315   Canakinumab   [9] 46, 56, 84, 106, 107, 108, 113, 266, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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