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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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112 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 2  Adrenergic signaling in cardiomyocytes 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 3  AGE-RAGE signaling pathway in diabetic complications 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] VEGFA, VEGFB   D09574   Aflibercept   [2] 90, 166 
 4  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 5  Alcoholism 
 3 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [2] DRD1, DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 6  Aldosterone synthesis and secretion 
 7 genes, 2 drugs (DrugBank), 14 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 7  Alzheimer disease 
 9 genes, 2 drugs (DrugBank), 44 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 8  Amphetamine addiction 
 9 genes, 4 drugs (DrugBank), 50 diseases shown 		  [2] CACNA1C, CACNA1D   D01908   Nilvadipine   [1] 90 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] DRD1   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 9  Amyotrophic lateral sclerosis (ALS) 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 10  Apoptosis - multiple species 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] NGFR   D11028   Cenegermin   [1] 90 
 11  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 12  Axon guidance 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 13  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 14  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 15  Bile secretion 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 D00653   Dorzolamide   [1] 90 
 D07871 
 16  Bladder cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 17  Butanoate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 18  C-type lectin receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 19  Calcium signaling pathway 
 15 genes, 5 drugs (DrugBank), 58 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [2] DRD1, DRD5   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] PTGFR   D08661   Unoprostone   [1] 90 
 20  cAMP signaling pathway 
 7 genes, 2 drugs (DrugBank), 7 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [3] DRD1, DRD2, DRD5   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 21  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CACNA1D   D01908   Nilvadipine   [1] 90 
 22  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 23  Cellular senescence 
 6 genes, 2 drugs (DrugBank), 44 diseases shown 		  [1] CACNA1D   D01908   Nilvadipine   [1] 90 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 24  cGMP-PKG signaling pathway 
 12 genes, 3 drugs (DrugBank), 44 diseases shown 		  [3] ADRA2A, ADRA2B, ADRA2C   D02076   Brimonidine   [1] 90 
 D07540 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 25  Chagas disease (American trypanosomiasis) 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 26  Cholinergic synapse 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 27  Circadian entrainment 
 7 genes, 3 drugs (DrugBank), 21 diseases shown 		  [2] CACNA1C, CACNA1D   D01908   Nilvadipine   [1] 90 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 28  Cocaine addiction 
 3 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [2] DRD1, DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 29  Collecting duct acid secretion 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 D00653   Dorzolamide   [1] 90 
 D07871 
 30  Cortisol synthesis and secretion 
 7 genes, 2 drugs (DrugBank), 14 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 31  Cushing syndrome 
 7 genes, 2 drugs (DrugBank), 14 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 32  Cytokine-cytokine receptor interaction 
 3 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] NGFR   D11028   Cenegermin   [1] 90 
 33  Dilated cardiomyopathy (DCM) 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 34  Dopaminergic synapse 
 11 genes, 4 drugs (DrugBank), 50 diseases shown 		  [2] CACNA1C, CACNA1D   D01908   Nilvadipine   [1] 90 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [5] DRD1, DRD2, DRD3, DRD4, DRD5   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 35  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 36  Estrogen signaling pathway 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 37  Fluid shear stress and atherosclerosis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 38  Focal adhesion 
 3 genes, 1 drug (DrugBank), 2 diseases shown 		  [3] PGF, VEGFA, VEGFB   D09574   Aflibercept   [2] 90, 166 
 39  GABAergic synapse 
 7 genes, 2 drugs (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 40  Gap junction 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] DRD1, DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 41  Gastric acid secretion 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 D00653   Dorzolamide   [1] 90 
 D07871 
 42  Gastric cancer 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 43  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 44  Glutamatergic synapse 
 7 genes, 2 drugs (DrugBank), 44 diseases shown 		  [2] CACNA1C, CACNA1D   D01908   Nilvadipine   [1] 90 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 45  GnRH secretion 
 7 genes, 2 drugs (DrugBank), 14 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 46  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 47  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 48  Herpes simplex virus 1 infection 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 49  HIF-1 signaling pathway 
 3 genes, 2 drugs (DrugBank), 8 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 50  Human cytomegalovirus infection 
 6 genes, 2 drugs (DrugBank), 45 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 51  Human immunodeficiency virus 1 infection 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 52  Human papillomavirus infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 53  Human T-cell leukemia virus 1 infection 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 54  Hypertrophic cardiomyopathy (HCM) 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 55  Inflammatory bowel disease (IBD) 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 56  Influenza A 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 57  Insulin secretion 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 58  JAK-STAT signaling pathway 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 59  Kaposi sarcoma-associated herpesvirus infection 
 7 genes, 3 drugs (DrugBank), 48 diseases shown 		  [1] IFNGR1   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 60  Leishmaniasis 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 61  Long-term potentiation 
 6 genes, 2 drugs (DrugBank), 44 diseases shown 		  [1] CACNA1C   D01908   Nilvadipine   [1] 90 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 62  MAPK signaling pathway 
 16 genes, 5 drugs (DrugBank), 55 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] NGFR   D11028   Cenegermin   [1] 90 
 [3] PGF, VEGFA, VEGFB   D09574   Aflibercept   [2] 90, 166 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 63  Metabolic pathways 
 18 genes, 4 drugs (DrugBank), 24 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 D00653   Dorzolamide   [1] 90 
 D07871 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 64  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 65  Morphine addiction 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] DRD1   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 66  Natural killer cell mediated cytotoxicity 
 7 genes, 2 drugs (DrugBank), 47 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 67  Necroptosis 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 68  Neuroactive ligand-receptor interaction 
 12 genes, 8 drugs (DrugBank), 40 diseases shown 		  [3] ADRA2A, ADRA2B, ADRA2C   D02076   Brimonidine   [1] 90 
 D07540 
 [5] DRD1, DRD2, DRD3, DRD4, DRD5   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 [1] NR3C1   D00244   Betamethasone   [6] 2, 46, 65, 90, 96, 235 
 D00972 
 D01357 
 D01402 
 D01637 
 D02032 
 D02286 
 D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D01825   Fluocinolone acetonide   [1] 90 
 D00385   Triamcinolone   [18] 6, 10, 13, 35, 40, 41, 42, 43, 44, 45, 46, 56, 70, 90, 96, 97, 226, 298 
 D00983 
 D00984 
 D00985 
 D06216 
 [1] PTGFR   D08661   Unoprostone   [1] 90 
 69  Neurotrophin signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] NGFR   D11028   Cenegermin   [1] 90 
 70  Nitrogen metabolism 
 13 genes, 2 drugs (DrugBank), 6 diseases shown 		  [13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 D00653   Dorzolamide   [1] 90 
 D07871 
 71  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 72  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 73  Osteoclast differentiation 
 7 genes, 2 drugs (DrugBank), 47 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 74  Oxytocin signaling pathway 
 9 genes, 2 drugs (DrugBank), 44 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 75  Pancreatic cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 76  Pancreatic secretion 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] CA2   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 D00653   Dorzolamide   [1] 90 
 D07871 
 77  Parkinson disease 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] DRD1, DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 78  Pathways in cancer 
 7 genes, 3 drugs (DrugBank), 11 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] PGF, VEGFA, VEGFB   D09574   Aflibercept   [2] 90, 166 
 [2] RARA, RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 79  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 7 genes, 2 drugs (DrugBank), 47 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 80  Phenylalanine metabolism 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 81  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PTGFR   D08661   Unoprostone   [1] 90 
 82  PI3K-Akt signaling pathway 
 4 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] NGFR   D11028   Cenegermin   [1] 90 
 [3] PGF, VEGFA, VEGFB   D09574   Aflibercept   [2] 90, 166 
 83  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 84  Proteoglycans in cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 85  Proximal tubule bicarbonate reclamation 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] CA2, CA4   D00218   Acetazolamide   [6] 13, 90, 115, 155, 225, 230 
 D01196 
 D00653   Dorzolamide   [1] 90 
 D07871 
 86  Rap1 signaling pathway 
 5 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] DRD2   D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] NGFR   D11028   Cenegermin   [1] 90 
 [3] PGF, VEGFA, VEGFB   D09574   Aflibercept   [2] 90, 166 
 87  Ras signaling pathway 
 4 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] NGFR   D11028   Cenegermin   [1] 90 
 [3] PGF, VEGFA, VEGFB   D09574   Aflibercept   [2] 90, 166 
 88  Relaxin signaling pathway 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] VEGFA, VEGFB   D09574   Aflibercept   [2] 90, 166 
 89  Renal cell carcinoma 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 90  Renin secretion 
 9 genes, 2 drugs (DrugBank), 44 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 91  Retrograde endocannabinoid signaling 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 92  Rheumatoid arthritis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 93  Salmonella infection 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 94  Serotonergic synapse 
 5 genes, 2 drugs (DrugBank), 8 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 95  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 96  T cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 97  Taste transduction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CACNA1C   D01908   Nilvadipine   [1] 90 
 98  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 99  Th1 and Th2 cell differentiation 
 7 genes, 2 drugs (DrugBank), 47 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 100  Th17 cell differentiation 
 8 genes, 3 drugs (DrugBank), 48 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 101  Tight junction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CACNA1D   D01908   Nilvadipine   [1] 90 
 102  Toxoplasmosis 
 2 genes, 1 drug (DrugBank), 7 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 103  Transcriptional misregulation in cancer 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [1] NGFR   D11028   Cenegermin   [1] 90 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 104  Tryptophan metabolism 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 105  Tuberculosis 
 7 genes, 2 drugs (DrugBank), 47 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 106  Type I diabetes mellitus 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 107  Type II diabetes mellitus 
 3 genes, 2 drugs (DrugBank), 14 diseases shown 		  [2] CACNA1C, CACNA1D   D01908   Nilvadipine   [1] 90 
 [1] CACNA1G   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 108  Tyrosine metabolism 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 109  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 110  Vascular smooth muscle contraction 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01908   Nilvadipine   [1] 90 
 111  VEGF signaling pathway 
 6 genes, 2 drugs (DrugBank), 45 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] VEGFA   D09574   Aflibercept   [2] 90, 166 
 112  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 

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