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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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201 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 3 genes, 4 drugs (DrugBank), 40 diseases shown 		  [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 2  Adherens junction 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 3  Adipocytokine signaling pathway 
 3 genes, 9 drugs (DrugBank), 68 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  Adrenergic signaling in cardiomyocytes 
 11 genes, 4 drugs (DrugBank), 29 diseases shown 		  [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] SCN5A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 5  African trypanosomiasis 
 3 genes, 7 drugs (DrugBank), 45 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  AGE-RAGE signaling pathway in diabetic complications 
 3 genes, 8 drugs (DrugBank), 54 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 7  Alcoholism 
 18 genes, 4 drugs (DrugBank), 10 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9   D06320   Vorinostat   [2] 19, 96 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 8  Aldosterone synthesis and secretion 
 6 genes, 3 drugs (DrugBank), 23 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] PDE2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 9  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 10  Allograft rejection 
 25 genes, 9 drugs (DrugBank), 52 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Alzheimer disease 
 15 genes, 9 drugs (DrugBank), 64 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 12  Amoebiasis 
 3 genes, 7 drugs (DrugBank), 45 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Amphetamine addiction 
 15 genes, 5 drugs (DrugBank), 38 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 14  AMPK signaling pathway 
 6 genes, 9 drugs (DrugBank), 59 diseases shown 		  [1] ADRA1A   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 15  Amyotrophic lateral sclerosis (ALS) 
 11 genes, 8 drugs (DrugBank), 61 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Antifolate resistance 
 3 genes, 7 drugs (DrugBank), 55 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 17  Antigen processing and presentation 
 21 genes, 7 drugs (DrugBank), 45 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 18  Apelin signaling pathway 
 5 genes, 5 drugs (DrugBank), 48 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] HDAC4, HDAC5   D06320   Vorinostat   [2] 19, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 19  Apoptosis 
 1 gene, 6 drugs (DrugBank), 43 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 20  Arachidonic acid metabolism 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 21  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 6 genes, 4 drugs (DrugBank), 10 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 22  Asthma 
 15 genes, 7 drugs (DrugBank), 45 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 23  Autoimmune thyroid disease 
 23 genes, 3 drugs (DrugBank), 26 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] CTLA4   D06657   Tremelimumab   [2] 65, 96 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 24  Autophagy - animal 
 2 genes, 3 drugs (DrugBank), 41 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 25  Autophagy - other 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 26  Axon guidance 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 27  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 28  Bile secretion 
 2 genes, 5 drugs (DrugBank), 28 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 [1] NR1H4   D00163   Chenodeoxycholic acid   [4] 20, 96, 234, 263 
 D00734   Ursodeoxycholic acid   [12] 6, 8, 20, 67, 84, 93, 94, 95, 96, 97, 234, 299 
 29  Breast cancer 
 6 genes, 6 drugs (DrugBank), 50 diseases shown 		  [2] ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 30  C-type lectin receptor signaling pathway 
 10 genes, 12 drugs (DrugBank), 62 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 31  Caffeine metabolism 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 32  Calcium signaling pathway 
 24 genes, 9 drugs (DrugBank), 47 diseases shown 		  [2] ADORA2A, PDE1B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [1] HRH1   D00480   Promethazine   [1] 96 
 D00494 
 D01242 
 D03290 
 [1] HTR4   D08236   Mosapride   [1] 96 
 D09205   Prucalopride   [3] 13, 51, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 33  cAMP signaling pathway 
 21 genes, 7 drugs (DrugBank), 25 diseases shown 		  [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] ADRB1, ADRB2   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [1] HTR4   D08236   Mosapride   [1] 96 
 D09205   Prucalopride   [3] 13, 51, 96 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 34  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 35  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 36  Cell adhesion molecules (CAMs) 
 27 genes, 8 drugs (DrugBank), 33 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] CTLA4   D06657   Tremelimumab   [2] 65, 96 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 37  Cell cycle 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 38  Cellular senescence 
 13 genes, 5 drugs (DrugBank), 53 diseases shown 		  [1] CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 39  Central carbon metabolism in cancer 
 2 genes, 3 drugs (DrugBank), 39 diseases shown 		  [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 40  cGMP-PKG signaling pathway 
 26 genes, 8 drugs (DrugBank), 59 diseases shown 		  [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] OPRD1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 41  Chagas disease (American trypanosomiasis) 
 6 genes, 9 drugs (DrugBank), 46 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 42  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 43  Chemokine signaling pathway 
 2 genes, 1 drug (DrugBank), 9 diseases shown 		  [2] JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 44  Choline metabolism in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 45  Cholinergic synapse 
 5 genes, 2 drugs (DrugBank), 12 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 46  Chronic myeloid leukemia 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 47  Circadian entrainment 
 7 genes, 2 drugs (DrugBank), 12 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 48  Cocaine addiction 
 6 genes, 2 drugs (DrugBank), 9 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 49  Collecting duct acid secretion 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 50  Colorectal cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 51  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] F10   D03213   Apixaban   [2] 96, 97 
 52  Cortisol synthesis and secretion 
 5 genes, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 53  Cushing syndrome 
 5 genes, 2 drugs (DrugBank), 20 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 54  Cytokine-cytokine receptor interaction 
 12 genes, 19 drugs (DrugBank), 73 diseases shown 		  [1] CSF2RA   D05803   Sargramostim   [6] 6, 28, 60, 62, 96, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] GHR   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] IL11RA   D05266   Oprelvekin   [2] 96, 288 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 55  Dilated cardiomyopathy (DCM) 
 8 genes, 11 drugs (DrugBank), 55 diseases shown 		  [1] ADRB1   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 56  DNA replication 
 2 genes, 1 drug (DrugBank), 9 diseases shown 		  [2] POLA1, POLA2   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 57  Dopaminergic synapse 
 9 genes, 5 drugs (DrugBank), 40 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [2] GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [3] PPP3CA, PPP3CB, PPP3CC   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SCN1A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 58  Drug metabolism - other enzymes 
 5 genes, 6 drugs (DrugBank), 43 diseases shown 		  [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 59  ECM-receptor interaction 
 2 genes, 3 drugs (DrugBank), 7 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 60  EGFR tyrosine kinase inhibitor resistance 
 4 genes, 6 drugs (DrugBank), 48 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 61  Endocrine and other factor-regulated calcium reabsorption 
 2 genes, 5 drugs (DrugBank), 26 diseases shown 		  [1] ESR1   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 62  Endocrine resistance 
 4 genes, 4 drugs (DrugBank), 44 diseases shown 		  [2] ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 63  Endocytosis 
 7 genes, 2 drugs (DrugBank), 9 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 64  Epstein-Barr virus infection 
 32 genes, 16 drugs (DrugBank), 51 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 65  ErbB signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 66  Estrogen signaling pathway 
 4 genes, 3 drugs (DrugBank), 17 diseases shown 		  [2] ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 67  Fc epsilon RI signaling pathway 
 1 gene, 6 drugs (DrugBank), 43 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 68  Fluid shear stress and atherosclerosis 
 2 genes, 7 drugs (DrugBank), 48 diseases shown 		  [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 69  Focal adhesion 
 3 genes, 4 drugs (DrugBank), 12 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 70  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 71  FoxO signaling pathway 
 4 genes, 3 drugs (DrugBank), 9 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [2] S1PR1, S1PR4   D10968   Ozanimod   [3] 13, 96, 97 
 72  GABAergic synapse 
 20 genes, 2 drugs (DrugBank), 13 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 73  Gap junction 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ADRB1   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 74  Gastric acid secretion 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 75  Gastric cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 76  Glioma 
 2 genes, 3 drugs (DrugBank), 41 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 77  Glucagon signaling pathway 
 6 genes, 2 drugs (DrugBank), 32 diseases shown 		  [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 78  Glutamatergic synapse 
 12 genes, 3 drugs (DrugBank), 37 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 79  Glutathione metabolism 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 80  GnRH secretion 
 5 genes, 2 drugs (DrugBank), 9 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 81  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 82  Graft-versus-host disease 
 23 genes, 8 drugs (DrugBank), 52 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 83  Growth hormone synthesis, secretion and action 
 8 genes, 7 drugs (DrugBank), 61 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] GHR   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 84  Hematopoietic cell lineage 
 25 genes, 17 drugs (DrugBank), 75 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] CSF2RA   D05803   Sargramostim   [6] 6, 28, 60, 62, 96, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL11RA   D05266   Oprelvekin   [2] 96, 288 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 D08083   Vedolizumab   [2] 96, 97 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 85  Hepatitis B 
 6 genes, 11 drugs (DrugBank), 47 diseases shown 		  [1] IFNAR1   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 86  Hepatitis C 
 5 genes, 11 drugs (DrugBank), 47 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  Hepatocellular carcinoma 
 3 genes, 4 drugs (DrugBank), 45 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 88  Herpes simplex virus 1 infection 
 29 genes, 15 drugs (DrugBank), 72 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 89  HIF-1 signaling pathway 
 3 genes, 4 drugs (DrugBank), 42 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 90  Hippo signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SMAD7   D10956   Mongersen   [2] 96, 97 
 91  Human cytomegalovirus infection 
 15 genes, 14 drugs (DrugBank), 76 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  Human immunodeficiency virus 1 infection 
 16 genes, 12 drugs (DrugBank), 72 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 93  Human papillomavirus infection 
 17 genes, 19 drugs (DrugBank), 74 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 94  Human T-cell leukemia virus 1 infection 
 33 genes, 16 drugs (DrugBank), 63 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 95  Huntington disease 
 5 genes, 3 drugs (DrugBank), 21 diseases shown 		  [2] GRIN1, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 96  Hypertrophic cardiomyopathy (HCM) 
 7 genes, 10 drugs (DrugBank), 50 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 97  IL-17 signaling pathway 
 2 genes, 7 drugs (DrugBank), 47 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 98  Inflammatory bowel disease (IBD) 
 18 genes, 11 drugs (DrugBank), 46 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 99  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] HRH1   D00480   Promethazine   [1] 96 
 D00494 
 D01242 
 D03290 
 100  Influenza A 
 23 genes, 15 drugs (DrugBank), 55 diseases shown 		  [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 101  Insulin resistance 
 3 genes, 9 drugs (DrugBank), 68 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 102  Insulin secretion 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 103  Insulin signaling pathway 
 3 genes, 4 drugs (DrugBank), 41 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 104  Intestinal immune network for IgA production 
 18 genes, 5 drugs (DrugBank), 29 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 105  JAK-STAT signaling pathway 
 15 genes, 17 drugs (DrugBank), 81 diseases shown 		  [1] CSF2RA   D05803   Sargramostim   [6] 6, 28, 60, 62, 96, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] GHR   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] IL11RA   D05266   Oprelvekin   [2] 96, 288 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 106  Kaposi sarcoma-associated herpesvirus infection 
 19 genes, 11 drugs (DrugBank), 67 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 107  Legionellosis 
 3 genes, 7 drugs (DrugBank), 45 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 108  Leishmaniasis 
 21 genes, 14 drugs (DrugBank), 54 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 D08083   Vedolizumab   [2] 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 109  Leukocyte transendothelial migration 
 2 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 D08083   Vedolizumab   [2] 96, 97 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 110  Long-term depression 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 111  Long-term potentiation 
 11 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] CACNA1C   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 112  Longevity regulating pathway 
 4 genes, 5 drugs (DrugBank), 47 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 113  Longevity regulating pathway - multiple species 
 5 genes, 5 drugs (DrugBank), 43 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 114  Malaria 
 3 genes, 8 drugs (DrugBank), 47 diseases shown 		  [1] IL12A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 115  MAPK signaling pathway 
 13 genes, 11 drugs (DrugBank), 66 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 116  Measles 
 10 genes, 8 drugs (DrugBank), 24 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 117  Melanogenesis 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 118  Melanoma 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 119  Metabolic pathways 
 23 genes, 17 drugs (DrugBank), 80 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 120  MicroRNAs in cancer 
 6 genes, 4 drugs (DrugBank), 42 diseases shown 		  [4] HDAC1, HDAC2, HDAC4, HDAC5   D06320   Vorinostat   [2] 19, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 121  Mineral absorption 
 1 gene, 4 drugs (DrugBank), 23 diseases shown 		  [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 122  Morphine addiction 
 26 genes, 3 drugs (DrugBank), 18 diseases shown 		  [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 123  mTOR signaling pathway 
 4 genes, 10 drugs (DrugBank), 72 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 124  Natural killer cell mediated cytotoxicity 
 14 genes, 11 drugs (DrugBank), 60 diseases shown 		  [5] HLA-A, HLA-B, HLA-C, HLA-E, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 125  Necroptosis 
 7 genes, 11 drugs (DrugBank), 47 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 126  Neuroactive ligand-receptor interaction 
 49 genes, 22 drugs (DrugBank), 95 diseases shown 		  [2] ADORA1, ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] CNR1, CNR2   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] GHR   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] GLP2R   D06053   Teduglutide   [1] 96 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [1] HRH1   D00480   Promethazine   [1] 96 
 D00494 
 D01242 
 D03290 
 [1] HTR4   D08236   Mosapride   [1] 96 
 D09205   Prucalopride   [3] 13, 51, 96 
 [1] NR3C1   D00244   Betamethasone   [6] 2, 46, 65, 90, 96, 235 
 D00972 
 D01357 
 D01402 
 D01637 
 D02032 
 D02286 
 D00246   Budesonide   [10] 66, 85, 93, 94, 95, 96, 97, 98, 228, 299 
 D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 D00385   Triamcinolone   [18] 6, 10, 13, 35, 40, 41, 42, 43, 44, 45, 46, 56, 70, 90, 96, 97, 226, 298 
 D00983 
 D00984 
 D00985 
 D06216 
 [3] OPRD1, OPRK1, OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5   D10968   Ozanimod   [3] 13, 96, 97 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 127  NF-kappa B signaling pathway 
 3 genes, 8 drugs (DrugBank), 50 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 128  Nicotine addiction 
 21 genes, 2 drugs (DrugBank), 13 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 129  NOD-like receptor signaling pathway 
 5 genes, 11 drugs (DrugBank), 47 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 130  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 7 drugs (DrugBank), 44 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 131  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 132  Notch signaling pathway 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 133  Olfactory transduction 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] PDE1B, PDE2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 134  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 135  Oocyte meiosis 
 7 genes, 3 drugs (DrugBank), 34 diseases shown 		  [1] AR   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 136  Osteoclast differentiation 
 12 genes, 14 drugs (DrugBank), 69 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 137  Ovarian steroidogenesis 
 3 genes, 3 drugs (DrugBank), 15 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 138  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 139  Oxytocin signaling pathway 
 10 genes, 3 drugs (DrugBank), 39 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 140  Pancreatic cancer 
 2 genes, 5 drugs (DrugBank), 44 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 141  Parathyroid hormone synthesis, secretion and action 
 6 genes, 6 drugs (DrugBank), 28 diseases shown 		  [4] PDE4A, PDE4B, PDE4C, PDE4D   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 142  Parkinson disease 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 143  Pathogenic Escherichia coli infection 
 1 gene, 6 drugs (DrugBank), 43 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 144  Pathways in cancer 
 24 genes, 23 drugs (DrugBank), 84 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [3] AR, ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] CSF2RA   D05803   Sargramostim   [6] 6, 28, 60, 62, 96, 229 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 145  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 12 genes, 9 drugs (DrugBank), 54 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 146  Peroxisome 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 147  Pertussis 
 4 genes, 10 drugs (DrugBank), 45 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 148  Phagosome 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 149  Phospholipase D signaling pathway 
 4 genes, 5 drugs (DrugBank), 49 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 150  PI3K-Akt signaling pathway 
 14 genes, 16 drugs (DrugBank), 77 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] GHR, IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 151  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 152  Primary immunodeficiency 
 3 genes, 3 drugs (DrugBank), 10 diseases shown 		  [2] CD3D, CD3E   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 153  Progesterone-mediated oocyte maturation 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 154  Prolactin signaling pathway 
 4 genes, 3 drugs (DrugBank), 17 diseases shown 		  [2] ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 155  Prostate cancer 
 3 genes, 4 drugs (DrugBank), 44 diseases shown 		  [1] AR   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 156  Proteoglycans in cancer 
 5 genes, 11 drugs (DrugBank), 74 diseases shown 		  [1] ESR1   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 157  Purine metabolism 
 14 genes, 8 drugs (DrugBank), 53 diseases shown 		  [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 158  Pyrimidine metabolism 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 159  Rap1 signaling pathway 
 9 genes, 7 drugs (DrugBank), 27 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [3] GRIN1, GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 160  Ras signaling pathway 
 6 genes, 4 drugs (DrugBank), 14 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 161  Regulation of actin cytoskeleton 
 3 genes, 4 drugs (DrugBank), 13 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 162  Regulation of lipolysis in adipocytes 
 7 genes, 4 drugs (DrugBank), 19 diseases shown 		  [2] ADORA1, PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [3] ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 163  Renin secretion 
 17 genes, 5 drugs (DrugBank), 45 diseases shown 		  [4] ADORA1, PDE1B, PDE3A, PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [3] ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 164  Renin-angiotensin system 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 165  Retrograde endocannabinoid signaling 
 22 genes, 4 drugs (DrugBank), 23 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 166  Rheumatoid arthritis 
 21 genes, 15 drugs (DrugBank), 55 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] CTLA4   D06657   Tremelimumab   [2] 65, 96 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF11   D03684   Denosumab   [7] 46, 50, 93, 95, 96, 274, 299 
 167  RIG-I-like receptor signaling pathway 
 3 genes, 7 drugs (DrugBank), 45 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 168  Salivary secretion 
 6 genes, 1 drug (DrugBank), 9 diseases shown 		  [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 169  Serotonergic synapse 
 9 genes, 5 drugs (DrugBank), 18 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [3] GABRB1, GABRB2, GABRB3   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] HTR4   D08236   Mosapride   [1] 96 
 D09205   Prucalopride   [3] 13, 51, 96 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 170  Shigellosis 
 2 genes, 8 drugs (DrugBank), 67 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 171  Signaling pathways regulating pluripotency of stem cells 
 4 genes, 4 drugs (DrugBank), 17 diseases shown 		  [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 172  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 173  Sphingolipid signaling pathway 
 8 genes, 9 drugs (DrugBank), 49 diseases shown 		  [1] ADORA1   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] OPRD1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5   D10968   Ozanimod   [3] 13, 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 174  Staphylococcus aureus infection 
 15 genes, 2 drugs (DrugBank), 11 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 175  Synaptic vesicle cycle 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] SLC6A2, SLC6A3   D00817   Bupropion   [2] 8, 96 
 D07591 
 D07938 
 176  Systemic lupus erythematosus 
 20 genes, 10 drugs (DrugBank), 55 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] ELANE   D03788   Sivelestat   [3] 13, 85, 96 
 [2] GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 177  T cell receptor signaling pathway 
 11 genes, 11 drugs (DrugBank), 57 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] CTLA4   D06657   Tremelimumab   [2] 65, 96 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 178  Taste transduction 
 11 genes, 4 drugs (DrugBank), 17 diseases shown 		  [1] CACNA1C   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] PDE1B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [3] SCN2A, SCN3A, SCN9A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 179  Terpenoid backbone biosynthesis 
 2 genes, 5 drugs (DrugBank), 26 diseases shown 		  [1] FDPS   D00942   Risedronic acid   [7] 46, 66, 93, 95, 96, 113, 274 
 D03234 
 D08484 
 D01968   Zoledronic acid   [11] 6, 13, 46, 65, 93, 95, 96, 271, 274, 299, 333 
 D06378 
 D06379 
 D08689 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 180  TGF-beta signaling pathway 
 2 genes, 7 drugs (DrugBank), 43 diseases shown 		  [1] SMAD7   D10956   Mongersen   [2] 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 181  Th1 and Th2 cell differentiation 
 28 genes, 8 drugs (DrugBank), 40 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 182  Th17 cell differentiation 
 29 genes, 14 drugs (DrugBank), 60 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 183  Thermogenesis 
 4 genes, 5 drugs (DrugBank), 55 diseases shown 		  [1] ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 184  Thyroid cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 185  Thyroid hormone signaling pathway 
 5 genes, 4 drugs (DrugBank), 41 diseases shown 		  [1] ESR1   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [3] HDAC1, HDAC2, HDAC3   D06320   Vorinostat   [2] 19, 96 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 186  Tight junction 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 187  TNF signaling pathway 
 2 genes, 7 drugs (DrugBank), 47 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 188  Toll-like receptor signaling pathway 
 7 genes, 10 drugs (DrugBank), 53 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 189  Toxoplasmosis 
 20 genes, 11 drugs (DrugBank), 47 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 190  Transcriptional misregulation in cancer 
 8 genes, 8 drugs (DrugBank), 39 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] ELANE   D03788   Sivelestat   [3] 13, 85, 96 
 [2] HDAC1, HDAC2   D06320   Vorinostat   [2] 19, 96 
 [1] IGF1R   D03297   Mecasermin   [6] 65, 78, 96, 168, 265, 299 
 D04870 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 D08083   Vedolizumab   [2] 96, 97 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 191  Tuberculosis 
 26 genes, 19 drugs (DrugBank), 63 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 192  Type I diabetes mellitus 
 25 genes, 9 drugs (DrugBank), 52 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 193  Type II diabetes mellitus 
 5 genes, 10 drugs (DrugBank), 71 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 194  Ubiquinone and other terpenoid-quinone biosynthesis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 195  Vascular smooth muscle contraction 
 9 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [3] ADRA1A, ADRA1B, ADRA1D   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 196  VEGF signaling pathway 
 6 genes, 2 drugs (DrugBank), 36 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 197  Viral carcinogenesis 
 19 genes, 5 drugs (DrugBank), 16 diseases shown 		  [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9   D06320   Vorinostat   [2] 19, 96 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 198  Viral myocarditis 
 23 genes, 3 drugs (DrugBank), 29 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 199  Viral protein interaction with cytokine and cytokine receptor 
 1 gene, 6 drugs (DrugBank), 43 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 200  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 201  Yersinia infection 
 2 genes, 8 drugs (DrugBank), 47 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 D08083   Vedolizumab   [2] 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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