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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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166 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 3 genes, 7 drugs (DrugBank), 40 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PRKCQ   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 2  Adrenergic signaling in cardiomyocytes 
 6 genes, 3 drugs (DrugBank), 27 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] SCN5A   D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 3  African trypanosomiasis 
 3 genes, 6 drugs (DrugBank), 41 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  AGE-RAGE signaling pathway in diabetic complications 
 5 genes, 8 drugs (DrugBank), 50 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [2] PRKCD, PRKCE   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 5  Alcoholism 
 8 genes, 3 drugs (DrugBank), 9 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] DRD1, DRD2   D01044   Flupentixol   [1] 97 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 6  Aldosterone synthesis and secretion 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] PDE2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] PRKCE   D09671   Sotrastaurin   [1] 97 
 7  Allograft rejection 
 5 genes, 7 drugs (DrugBank), 49 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 8  Alzheimer disease 
 11 genes, 8 drugs (DrugBank), 72 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  Amoebiasis 
 3 genes, 6 drugs (DrugBank), 41 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Amphetamine addiction 
 11 genes, 4 drugs (DrugBank), 59 diseases shown 		  [1] DRD1   D01044   Flupentixol   [1] 97 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 11  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 12  Amyotrophic lateral sclerosis (ALS) 
 11 genes, 8 drugs (DrugBank), 72 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Antifolate resistance 
 3 genes, 6 drugs (DrugBank), 53 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 14  Antigen processing and presentation 
 1 gene, 5 drugs (DrugBank), 39 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Apelin signaling pathway 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] PRKCE   D09671   Sotrastaurin   [1] 97 
 16  Apoptosis 
 1 gene, 5 drugs (DrugBank), 39 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 17  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 6 genes, 3 drugs (DrugBank), 8 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 18  Asthma 
 2 genes, 7 drugs (DrugBank), 39 diseases shown 		  [1] IL13   D08857   Anrukinzumab   [1] 97 
 D09979   Tralokinumab   [2] 85, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 19  Autoimmune thyroid disease 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 20  Autophagy - animal 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] PRKCD, PRKCQ   D09671   Sotrastaurin   [1] 97 
 21  Axon guidance 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 22  B cell receptor signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 23  Bile secretion 
 1 gene, 1 drug (DrugBank), 12 diseases shown 		  [1] NR1H4   D00734   Ursodeoxycholic acid   [12] 6, 8, 20, 67, 84, 93, 94, 95, 96, 97, 234, 299 
 24  C-type lectin receptor signaling pathway 
 10 genes, 12 drugs (DrugBank), 69 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PRKCD   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 25  Caffeine metabolism 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 26  Calcium signaling pathway 
 13 genes, 6 drugs (DrugBank), 65 diseases shown 		  [2] ADORA2A, PDE1B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] DRD1   D01044   Flupentixol   [1] 97 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 27  cAMP signaling pathway 
 15 genes, 4 drugs (DrugBank), 12 diseases shown 		  [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] DRD1, DRD2   D01044   Flupentixol   [1] 97 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D08860   Apremilast   [5] 46, 50, 56, 97, 271 
 28  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 7 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 29  Cell adhesion molecules (CAMs) 
 5 genes, 4 drugs (DrugBank), 25 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 30  Cellular senescence 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 31  cGMP-PKG signaling pathway 
 13 genes, 7 drugs (DrugBank), 66 diseases shown 		  [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] OPRD1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PRKCE   D09671   Sotrastaurin   [1] 97 
 32  Chagas disease (American trypanosomiasis) 
 6 genes, 8 drugs (DrugBank), 42 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 33  Chemokine signaling pathway 
 3 genes, 2 drugs (DrugBank), 9 diseases shown 		  [2] JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PRKCD   D09671   Sotrastaurin   [1] 97 
 34  Cholinergic synapse 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 35  Circadian entrainment 
 7 genes, 2 drugs (DrugBank), 13 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 36  Cocaine addiction 
 7 genes, 2 drugs (DrugBank), 9 diseases shown 		  [2] DRD1, DRD2   D01044   Flupentixol   [1] 97 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 37  Collecting duct acid secretion 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 38  Complement and coagulation cascades 
 2 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] F10   D03213   Apixaban   [2] 96, 97 
 [1] SERPINC1   D07510   Parnaparin   [1] 97 
 39  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 40  Cushing syndrome 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 41  Cytokine-cytokine receptor interaction 
 13 genes, 17 drugs (DrugBank), 48 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL13   D08857   Anrukinzumab   [1] 97 
 D09979   Tralokinumab   [2] 85, 97 
 [2] IL17A, IL17F   D11550   Bimekizumab   [3] 46, 97, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 42  Dilated cardiomyopathy (DCM) 
 7 genes, 8 drugs (DrugBank), 42 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 43  Dopaminergic synapse 
 8 genes, 5 drugs (DrugBank), 63 diseases shown 		  [2] DRD1, DRD2   D01044   Flupentixol   [1] 97 
 [2] GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SCN1A   D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 44  Drug metabolism - other enzymes 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 45  ECM-receptor interaction 
 2 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 46  EGFR tyrosine kinase inhibitor resistance 
 2 genes, 4 drugs (DrugBank), 14 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 47  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 2 drugs (DrugBank), 16 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 48  Endocytosis 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 49  Epstein-Barr virus infection 
 9 genes, 12 drugs (DrugBank), 45 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 50  Estrogen signaling pathway 
 2 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] OPRM1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [1] PRKCD   D09671   Sotrastaurin   [1] 97 
 51  Fc epsilon RI signaling pathway 
 2 genes, 7 drugs (DrugBank), 39 diseases shown 		  [1] IL13   D08857   Anrukinzumab   [1] 97 
 D09979   Tralokinumab   [2] 85, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 52  Fc gamma R-mediated phagocytosis 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] PRKCD, PRKCE   D09671   Sotrastaurin   [1] 97 
 53  Fluid shear stress and atherosclerosis 
 1 gene, 5 drugs (DrugBank), 39 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 54  Focal adhesion 
 2 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 55  Folate biosynthesis 
 4 genes, 2 drugs (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [2] TPH1, TPH2   D09973   Telotristat   [1] 97 
 56  FoxO signaling pathway 
 2 genes, 2 drugs (DrugBank), 3 diseases shown 		  [2] S1PR1, S1PR4   D10930   Etrasimod   [1] 97 
 D10968   Ozanimod   [3] 13, 96, 97 
 57  GABAergic synapse 
 17 genes, 2 drugs (DrugBank), 12 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] SLC6A1   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 58  Gap junction 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] DRD1, DRD2   D01044   Flupentixol   [1] 97 
 59  Gastric acid secretion 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 60  Glucagon signaling pathway 
 6 genes, 3 drugs (DrugBank), 57 diseases shown 		  [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 61  Glutamatergic synapse 
 10 genes, 3 drugs (DrugBank), 59 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 62  GnRH signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PRKCD   D09671   Sotrastaurin   [1] 97 
 63  Graft-versus-host disease 
 3 genes, 6 drugs (DrugBank), 49 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 64  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 65  Hematopoietic cell lineage 
 7 genes, 12 drugs (DrugBank), 63 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] IL2RA   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [1] ITGA4   D08083   Vedolizumab   [2] 96, 97 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 66  Hepatitis B 
 6 genes, 10 drugs (DrugBank), 45 diseases shown 		  [1] IFNAR1   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 67  Hepatitis C 
 5 genes, 10 drugs (DrugBank), 45 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 68  Herpes simplex virus 1 infection 
 8 genes, 11 drugs (DrugBank), 46 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 69  Hippo signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SMAD7   D10956   Mongersen   [2] 96, 97 
 70  Human cytomegalovirus infection 
 7 genes, 11 drugs (DrugBank), 69 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 71  Human immunodeficiency virus 1 infection 
 9 genes, 9 drugs (DrugBank), 68 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 72  Human papillomavirus infection 
 7 genes, 12 drugs (DrugBank), 45 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 73  Human T-cell leukemia virus 1 infection 
 14 genes, 16 drugs (DrugBank), 69 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 74  Huntington disease 
 3 genes, 2 drugs (DrugBank), 12 diseases shown 		  [2] GRIN1, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 75  Hypertrophic cardiomyopathy (HCM) 
 7 genes, 8 drugs (DrugBank), 42 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 76  IL-17 signaling pathway 
 4 genes, 8 drugs (DrugBank), 39 diseases shown 		  [1] IL13   D08857   Anrukinzumab   [1] 97 
 D09979   Tralokinumab   [2] 85, 97 
 [2] IL17A, IL17F   D11550   Bimekizumab   [3] 46, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 77  Inflammatory bowel disease (IBD) 
 8 genes, 13 drugs (DrugBank), 41 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL13   D08857   Anrukinzumab   [1] 97 
 D09979   Tralokinumab   [2] 85, 97 
 [2] IL17A, IL17F   D11550   Bimekizumab   [3] 46, 97, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 78  Inflammatory mediator regulation of TRP channels 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] PRKCD, PRKCE, PRKCH, PRKCQ   D09671   Sotrastaurin   [1] 97 
 79  Influenza A 
 8 genes, 11 drugs (DrugBank), 46 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 80  Insulin resistance 
 4 genes, 6 drugs (DrugBank), 39 diseases shown 		  [3] PRKCD, PRKCE, PRKCQ   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 81  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 82  Intestinal immune network for IgA production 
 4 genes, 3 drugs (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 83  JAK-STAT signaling pathway 
 13 genes, 14 drugs (DrugBank), 28 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL13   D08857   Anrukinzumab   [1] 97 
 D09979   Tralokinumab   [2] 85, 97 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 84  Kaposi sarcoma-associated herpesvirus infection 
 11 genes, 8 drugs (DrugBank), 61 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 85  Legionellosis 
 3 genes, 6 drugs (DrugBank), 41 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 86  Leishmaniasis 
 6 genes, 11 drugs (DrugBank), 44 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGA4   D08083   Vedolizumab   [2] 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  Leukocyte transendothelial migration 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ITGA4   D08083   Vedolizumab   [2] 96, 97 
 88  Long-term potentiation 
 10 genes, 3 drugs (DrugBank), 59 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 89  Longevity regulating pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 90  Malaria 
 2 genes, 6 drugs (DrugBank), 41 diseases shown 		  [1] IL12A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 91  MAPK signaling pathway 
 10 genes, 8 drugs (DrugBank), 70 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  Measles 
 13 genes, 11 drugs (DrugBank), 27 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 93  Metabolic pathways 
 18 genes, 8 drugs (DrugBank), 48 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] GUCY2C   D09355   Linaclotide   [1] 97 
 [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D08860   Apremilast   [5] 46, 50, 56, 97, 271 
 [2] TPH1, TPH2   D09973   Telotristat   [1] 97 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 94  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PRKCE   D09671   Sotrastaurin   [1] 97 
 95  Mineral absorption 
 1 gene, 2 drugs (DrugBank), 16 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 96  Morphine addiction 
 27 genes, 6 drugs (DrugBank), 21 diseases shown 		  [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] DRD1   D01044   Flupentixol   [1] 97 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] OPRM1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D08860   Apremilast   [5] 46, 50, 56, 97, 271 
 97  mTOR signaling pathway 
 1 gene, 5 drugs (DrugBank), 39 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 98  Natural killer cell mediated cytotoxicity 
 8 genes, 8 drugs (DrugBank), 68 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 99  Necroptosis 
 7 genes, 10 drugs (DrugBank), 45 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 100  Neuroactive ligand-receptor interaction 
 39 genes, 21 drugs (DrugBank), 85 diseases shown 		  [2] ADORA1, ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] CNR1, CNR2   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [2] DRD1, DRD2   D01044   Flupentixol   [1] 97 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 [1] NR3C1   D00689   Beclomethasone dipropionate   [2] 97, 98 
 D07495 
 D00246   Budesonide   [10] 66, 85, 93, 94, 95, 96, 97, 98, 228, 299 
 D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00088   Hydrocortisone   [8] 6, 53, 75, 78, 81, 83, 97, 299 
 D00165   Hydrocortisone acetate   [8] 6, 53, 75, 78, 81, 83, 97, 299 
 D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D05000   Methylprednisolone hemisuccinate   [2] 13, 97 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 D00385   Triamcinolone   [18] 6, 10, 13, 35, 40, 41, 42, 43, 44, 45, 46, 56, 70, 90, 96, 97, 226, 298 
 D00983 
 D00984 
 D00985 
 D06216 
 [3] OPRD1, OPRK1, OPRM1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5   D10930   Etrasimod   [1] 97 
 D10968   Ozanimod   [3] 13, 96, 97 
 101  Neurotrophin signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PRKCD   D09671   Sotrastaurin   [1] 97 
 102  NF-kappa B signaling pathway 
 3 genes, 7 drugs (DrugBank), 40 diseases shown 		  [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [1] PRKCQ   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 103  Nicotine addiction 
 21 genes, 2 drugs (DrugBank), 13 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 104  NOD-like receptor signaling pathway 
 6 genes, 11 drugs (DrugBank), 45 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PRKCD   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 105  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 5 drugs (DrugBank), 39 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 106  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 107  Olfactory transduction 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] PDE1B, PDE2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 108  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 109  Oocyte meiosis 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 110  Osteoclast differentiation 
 11 genes, 13 drugs (DrugBank), 71 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 111  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 112  Oxytocin signaling pathway 
 9 genes, 3 drugs (DrugBank), 58 diseases shown 		  [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 113  Pancreatic cancer 
 1 gene, 4 drugs (DrugBank), 14 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 114  Parathyroid hormone synthesis, secretion and action 
 5 genes, 4 drugs (DrugBank), 21 diseases shown 		  [4] PDE4A, PDE4B, PDE4C, PDE4D   D08860   Apremilast   [5] 46, 50, 56, 97, 271 
 D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 115  Parkinson disease 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] DRD1, DRD2   D01044   Flupentixol   [1] 97 
 116  Pathogenic Escherichia coli infection 
 1 gene, 5 drugs (DrugBank), 39 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 117  Pathways in cancer 
 14 genes, 16 drugs (DrugBank), 41 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL13   D08857   Anrukinzumab   [1] 97 
 D09979   Tralokinumab   [2] 85, 97 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 118  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 12 genes, 10 drugs (DrugBank), 58 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PRKCQ   D09671   Sotrastaurin   [1] 97 
 119  Peroxisome 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 120  Pertussis 
 4 genes, 9 drugs (DrugBank), 41 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 121  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 122  PI3K-Akt signaling pathway 
 10 genes, 10 drugs (DrugBank), 23 diseases shown 		  [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 123  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 124  Primary immunodeficiency 
 4 genes, 4 drugs (DrugBank), 12 diseases shown 		  [2] CD3D, CD3E   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 125  Progesterone-mediated oocyte maturation 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 126  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 127  Proteoglycans in cancer 
 2 genes, 6 drugs (DrugBank), 41 diseases shown 		  [1] IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 128  Purine metabolism 
 12 genes, 5 drugs (DrugBank), 14 diseases shown 		  [1] GUCY2C   D09355   Linaclotide   [1] 97 
 [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [4] PDE4A, PDE4B, PDE4C, PDE4D   D08860   Apremilast   [5] 46, 50, 56, 97, 271 
 [1] XDH   D00224   Allopurinol   [6] 6, 46, 57, 66, 96, 97 
 129  Rap1 signaling pathway 
 6 genes, 4 drugs (DrugBank), 17 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [1] DRD2   D01044   Flupentixol   [1] 97 
 [3] GRIN1, GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 130  Ras signaling pathway 
 3 genes, 1 drug (DrugBank), 9 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 131  Regulation of actin cytoskeleton 
 2 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] ITGA4, ITGB7   D08083   Vedolizumab   [2] 96, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 132  Regulation of lipolysis in adipocytes 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] ADORA1, PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 133  Renin secretion 
 10 genes, 4 drugs (DrugBank), 63 diseases shown 		  [4] ADORA1, PDE1B, PDE3A, PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 134  Renin-angiotensin system 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 135  Retrograde endocannabinoid signaling 
 17 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 136  Rheumatoid arthritis 
 6 genes, 12 drugs (DrugBank), 49 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL17A   D11550   Bimekizumab   [3] 46, 97, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 137  RIG-I-like receptor signaling pathway 
 3 genes, 6 drugs (DrugBank), 41 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 138  Serotonergic synapse 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [3] GABRB1, GABRB2, GABRB3   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [2] TPH1, TPH2   D09973   Telotristat   [1] 97 
 139  Shigellosis 
 4 genes, 6 drugs (DrugBank), 39 diseases shown 		  [3] PRKCD, PRKCE, PRKCQ   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 140  Signaling pathways regulating pluripotency of stem cells 
 3 genes, 4 drugs (DrugBank), 14 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 141  Sphingolipid signaling pathway 
 9 genes, 11 drugs (DrugBank), 45 diseases shown 		  [1] ADORA1   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] OPRD1   D00729   Loperamide   [2] 13, 97 
 D07113 
 D08144 
 D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [1] PRKCE   D09671   Sotrastaurin   [1] 97 
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5   D10930   Etrasimod   [1] 97 
 D10968   Ozanimod   [3] 13, 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 142  Synaptic vesicle cycle 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] SLC6A1   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 143  Systemic lupus erythematosus 
 5 genes, 7 drugs (DrugBank), 53 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 144  T cell receptor signaling pathway 
 11 genes, 11 drugs (DrugBank), 68 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PRKCQ   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 145  Taste transduction 
 10 genes, 3 drugs (DrugBank), 16 diseases shown 		  [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] PDE1B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [3] SCN2A, SCN3A, SCN9A   D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 146  TGF-beta signaling pathway 
 2 genes, 6 drugs (DrugBank), 39 diseases shown 		  [1] SMAD7   D10956   Mongersen   [2] 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 147  Th1 and Th2 cell differentiation 
 19 genes, 15 drugs (DrugBank), 60 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL13   D08857   Anrukinzumab   [1] 97 
 D09979   Tralokinumab   [2] 85, 97 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PRKCQ   D09671   Sotrastaurin   [1] 97 
 148  Th17 cell differentiation 
 19 genes, 17 drugs (DrugBank), 60 diseases shown 		  [3] CD3D, CD3E, CD3G   D05092   Muromonab   [3] 60, 96, 97 
 D06314   Visilizumab   [2] 96, 97 
 [2] IL17A, IL17F   D11550   Bimekizumab   [3] 46, 97, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PRKCQ   D09671   Sotrastaurin   [1] 97 
 149  Thermogenesis 
 2 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 150  Thyroid cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 151  Tight junction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PRKCE   D09671   Sotrastaurin   [1] 97 
 152  TNF signaling pathway 
 1 gene, 5 drugs (DrugBank), 39 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 153  Toll-like receptor signaling pathway 
 7 genes, 8 drugs (DrugBank), 51 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IFNAR1, IFNAR2   D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 154  Toxoplasmosis 
 6 genes, 10 drugs (DrugBank), 44 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 155  Transcriptional misregulation in cancer 
 4 genes, 5 drugs (DrugBank), 27 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL2RB   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] ITGB7   D09901   Etrolizumab   [2] 96, 97 
 D08083   Vedolizumab   [2] 96, 97 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 156  Tryptophan metabolism 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] TPH1, TPH2   D09973   Telotristat   [1] 97 
 157  Tuberculosis 
 12 genes, 17 drugs (DrugBank), 72 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL23A   D10438   Guselkumab   [3] 37, 96, 97 
 D11123   Mirikizumab   [2] 96, 97 
 D11052   Risankizumab   [4] 37, 96, 97, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 D00187   Ergocalciferol   [5] 46, 84, 96, 97, 299 
 158  Type I diabetes mellitus 
 5 genes, 7 drugs (DrugBank), 49 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 159  Type II diabetes mellitus 
 3 genes, 6 drugs (DrugBank), 39 diseases shown 		  [2] PRKCD, PRKCE   D09671   Sotrastaurin   [1] 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 160  Vascular smooth muscle contraction 
 6 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] PRKCD, PRKCE, PRKCH, PRKCQ   D09671   Sotrastaurin   [1] 97 
 161  VEGF signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 162  Viral carcinogenesis 
 2 genes, 4 drugs (DrugBank), 14 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 D10944   Itacitinib   [4] 46, 60, 97, 228 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 163  Viral myocarditis 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 164  Viral protein interaction with cytokine and cytokine receptor 
 4 genes, 8 drugs (DrugBank), 45 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 D03639   Daclizumab   [7] 13, 56, 60, 65, 97, 283, 284 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 165  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 166  Yersinia infection 
 2 genes, 6 drugs (DrugBank), 39 diseases shown 		  [1] ITGA4   D08083   Vedolizumab   [2] 96, 97 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 D04358   Golimumab   [5] 46, 84, 96, 97, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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