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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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45 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adrenergic signaling in cardiomyocytes 
 7 genes, 6 drugs (DrugBank), 25 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 [2] ADRB1, ADRB2   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 2  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 3  Aldosterone synthesis and secretion 
 5 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 4  Alzheimer disease 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 5  Amphetamine addiction 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 6  Apelin signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 7  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 8  Calcium signaling pathway 
 8 genes, 6 drugs (DrugBank), 25 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 9  cAMP signaling pathway 
 6 genes, 4 drugs (DrugBank), 10 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 [2] ADRB1, ADRB2   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 10  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 11  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 12  Cellular senescence 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 13  cGMP-PKG signaling pathway 
 8 genes, 6 drugs (DrugBank), 25 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 14  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ACE   D00624   Perindopril   [2] 167, 222 
 D03753 
 15  Cholinergic synapse 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 16  Circadian entrainment 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 17  Cortisol synthesis and secretion 
 5 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 18  Cushing syndrome 
 5 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 19  Dilated cardiomyopathy (DCM) 
 5 genes, 4 drugs (DrugBank), 10 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 20  Dopaminergic synapse 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 21  GABAergic synapse 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 22  Gap junction 
 1 gene, 3 drugs (DrugBank), 7 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 23  Glutamatergic synapse 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 24  GnRH secretion 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 25  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 26  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 27  Hypertrophic cardiomyopathy (HCM) 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] ACE   D00624   Perindopril   [2] 167, 222 
 D03753 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 28  Insulin secretion 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 29  Long-term potentiation 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1C   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 30  MAPK signaling pathway 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 31  Neuroactive ligand-receptor interaction 
 4 genes, 5 drugs (DrugBank), 23 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 32  Oxytocin signaling pathway 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 33  Pathways in cancer 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 34  Phospholipase D signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 35  Regulation of lipolysis in adipocytes 
 3 genes, 3 drugs (DrugBank), 7 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 36  Renin secretion 
 10 genes, 8 drugs (DrugBank), 25 diseases shown 		  [1] ACE   D00624   Perindopril   [2] 167, 222 
 D03753 
 [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 [1] REN   D03208   Aliskiren   [3] 66, 167, 222 
 37  Renin-angiotensin system 
 3 genes, 4 drugs (DrugBank), 19 diseases shown 		  [1] ACE   D00624   Perindopril   [2] 167, 222 
 D03753 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] REN   D03208   Aliskiren   [3] 66, 167, 222 
 38  Retrograde endocannabinoid signaling 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 39  Salivary secretion 
 3 genes, 3 drugs (DrugBank), 7 diseases shown 		  [1] ADRB1   D00235   Atenolol   [1] 167 
 D05127   Nebivolol   [3] 17, 113, 167 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 40  Serotonergic synapse 
 4 genes, 1 drug (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 41  Taste transduction 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1C   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 42  Thermogenesis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 43  Tight junction 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 44  Type II diabetes mellitus 
 2 genes, 1 drug (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 
 45  Vascular smooth muscle contraction 
 5 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   [4] 96, 130, 140, 167 
 D02356 

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