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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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29 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  ABC transporters 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] ABCC8   D00418   Minoxidil   [1] 179 
 2  Adrenergic signaling in cardiomyocytes 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 3  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4  Alcoholism 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 5  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 6  Amphetamine addiction 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 7  Apelin signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 8  Calcium signaling pathway 
 2 genes, 2 drugs (DrugBank), 22 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 9  cAMP signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 10  cGMP-PKG signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 11  Cocaine addiction 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 12  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 13  Cushing syndrome 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 14  Dopaminergic synapse 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 15  Gap junction 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] DRD2, HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 16  GnRH secretion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] KCNJ11   D00418   Minoxidil   [1] 179 
 17  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 18  Insulin secretion 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] ABCC8, KCNJ11   D00418   Minoxidil   [1] 179 
 19  Neuroactive ligand-receptor interaction 
 3 genes, 2 drugs (DrugBank), 22 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [2] DRD2, HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 20  Parkinson disease 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [1] SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 21  Pathways in cancer 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 22  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 23  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 24  Renin secretion 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 25  Renin-angiotensin system 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 26  Serotonergic synapse 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [1] SLC6A4   D00326   Fluoxetine   [6] 13, 17, 78, 86, 179, 206 
 D00823 
 27  Synaptic vesicle cycle 
 3 genes, 2 drugs (DrugBank), 10 diseases shown 		  [2] SLC6A2, SLC6A3   D01296   Methylphenidate   [7] 6, 13, 34, 84, 113, 179, 206 
 D04999 
 [1] SLC6A4   D00326   Fluoxetine   [6] 13, 17, 78, 86, 179, 206 
 D00823 
 28  Type II diabetes mellitus 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] ABCC8, KCNJ11   D00418   Minoxidil   [1] 179 
 29  Vascular smooth muscle contraction 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 

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