Target Gene/Pathway
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z other
| No. | KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * [Number of genes] |
KEGG DRUG * | DrugBank | Disease ID * [Number of diseases] |
| 1 | Calcium signaling pathway |
[2] EDNRA, EDNRB | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 | |||
| 2 | cAMP signaling pathway |
[1] EDNRA | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 | |||
| 3 | cGMP-PKG signaling pathway |
[2] EDNRA, EDNRB | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 | |||
| [1] PDE5A | D02229 | Sildenafil | [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 | ||
| D08514 | |||||
| 4 | Melanogenesis |
[1] EDNRB | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 | |||
| 5 | Metabolic pathways |
[1] PDE5A | D02229 | Sildenafil | [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 |
| D08514 | |||||
| 6 | Neuroactive ligand-receptor interaction |
[2] EDNRA, EDNRB | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 | |||
| 7 | Pathways in cancer |
[2] EDNRA, EDNRB | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 | |||
| 8 | Purine metabolism |
[1] PDE5A | D02229 | Sildenafil | [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 |
| D08514 | |||||
| 9 | Relaxin signaling pathway |
[1] EDNRB | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 | |||
| 10 | Renin secretion |
[1] EDNRA | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 | |||
| 11 | Vascular smooth muscle contraction |
[1] EDNRA | D01227 | Bosentan | [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 |
| D07538 | |||||
| D10135 | Macitentan | [5] 51, 85, 86, 88, 210 |