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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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134 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 2  Adrenergic signaling in cardiomyocytes 
 14 genes, 6 drugs (DrugBank), 21 diseases shown 		  [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] SCN5A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 3  African trypanosomiasis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 4  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 5  Aldosterone synthesis and secretion 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 6  Allograft rejection 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 7  Alzheimer disease 
 10 genes, 5 drugs (DrugBank), 59 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 8  Amoebiasis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 9  Amphetamine addiction 
 7 genes, 3 drugs (DrugBank), 55 diseases shown 		  [2] CACNA1C, CACNA1D   D08441   Propiverine   [1] 226 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 10  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ADRA1A   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 11  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 4 drugs (DrugBank), 59 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 12  Antifolate resistance 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 13  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 14  Apoptosis 
 2 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] NGF   D09387   Tanezumab   [2] 226, 298 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 15  Arachidonic acid metabolism 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] PTGS1, PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 16  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 8 genes, 2 drugs (DrugBank), 7 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 17  Asthma 
 2 genes, 3 drugs (DrugBank), 20 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 18  Axon guidance 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 19  B cell receptor signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 20  Breast cancer 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 21  C-type lectin receptor signaling pathway 
 7 genes, 5 drugs (DrugBank), 60 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 22  Calcium signaling pathway 
 21 genes, 8 drugs (DrugBank), 64 diseases shown 		  [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM2, CHRM3, CHRM5   D08441   Propiverine   [1] 226 
 [1] OXTR   D00089   Oxytocin   [4] 127, 193, 206, 226 
 [1] P2RX3   D11349   Gefapixant   [2] 85, 226 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 23  cAMP signaling pathway 
 9 genes, 4 drugs (DrugBank), 17 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [2] ADRB1, ADRB2   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [6] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM2   D08441   Propiverine   [1] 226 
 [1] OXTR   D00089   Oxytocin   [4] 127, 193, 206, 226 
 24  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CACNA1D   D08441   Propiverine   [1] 226 
 25  Cardiac muscle contraction 
 8 genes, 2 drugs (DrugBank), 7 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 26  Cellular senescence 
 6 genes, 3 drugs (DrugBank), 55 diseases shown 		  [1] CACNA1D   D08441   Propiverine   [1] 226 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 27  cGMP-PKG signaling pathway 
 20 genes, 10 drugs (DrugBank), 75 diseases shown 		  [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [3] ADRA2A, ADRA2B, ADRA2C   D00514   Dexmedetomidine   [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 
 D01205 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [1] OPRD1   D01340   Naloxone   [2] 6, 226 
 D08249 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 28  Chagas disease (American trypanosomiasis) 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 29  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 30  Cholinergic synapse 
 9 genes, 1 drug (DrugBank), 1 disease shown 		  [9] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D08441   Propiverine   [1] 226 
 31  Circadian entrainment 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] CACNA1C, CACNA1D   D08441   Propiverine   [1] 226 
 32  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] SERPINC1   D07510   Heparin   [11] 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 
 33  Cortisol synthesis and secretion 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 34  Cushing syndrome 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 35  Cytokine-cytokine receptor interaction 
 2 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] NGF   D09387   Tanezumab   [2] 226, 298 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 36  Dilated cardiomyopathy (DCM) 
 10 genes, 6 drugs (DrugBank), 29 diseases shown 		  [1] ADRB1   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 37  Dopaminergic synapse 
 6 genes, 5 drugs (DrugBank), 62 diseases shown 		  [2] CACNA1C, CACNA1D   D08441   Propiverine   [1] 226 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SCN1A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 38  Drug metabolism - other enzymes 
 2 genes, 2 drugs (DrugBank), 34 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 39  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 40  Endocrine resistance 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 41  Epstein-Barr virus infection 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 42  Estrogen signaling pathway 
 3 genes, 4 drugs (DrugBank), 11 diseases shown 		  [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 [1] OPRM1   D01340   Naloxone   [2] 6, 226 
 D08249 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 D01355   Tramadol   [5] 46, 70, 78, 226, 271 
 D08623 
 43  Fc epsilon RI signaling pathway 
 2 genes, 3 drugs (DrugBank), 20 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 44  Fluid shear stress and atherosclerosis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 45  GABAergic synapse 
 5 genes, 2 drugs (DrugBank), 7 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [1] SLC6A1   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 46  Gap junction 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] ADRB1   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 47  Gastric acid secretion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CHRM3   D08441   Propiverine   [1] 226 
 48  Glucagon signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 49  Glutamatergic synapse 
 7 genes, 3 drugs (DrugBank), 55 diseases shown 		  [2] CACNA1C, CACNA1D   D08441   Propiverine   [1] 226 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 50  GnRH secretion 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [1] ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 51  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 52  Graft-versus-host disease 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 53  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank), 1 disease shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 54  Hematopoietic cell lineage 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 55  Hepatitis B 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 56  Hepatitis C 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 57  Herpes simplex virus 1 infection 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 58  Human cytomegalovirus infection 
 7 genes, 5 drugs (DrugBank), 60 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 59  Human immunodeficiency virus 1 infection 
 6 genes, 4 drugs (DrugBank), 59 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 60  Human papillomavirus infection 
 2 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 61  Human T-cell leukemia virus 1 infection 
 6 genes, 4 drugs (DrugBank), 59 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 62  Hypertrophic cardiomyopathy (HCM) 
 9 genes, 4 drugs (DrugBank), 19 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 63  IL-17 signaling pathway 
 2 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 64  Inflammatory bowel disease (IBD) 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 65  Inflammatory mediator regulation of TRP channels 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] NGF   D09387   Tanezumab   [2] 226, 298 
 [1] TRPV1   D00250   Capsaicin   [6] 2, 6, 19, 86, 113, 226 
 66  Influenza A 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 67  Insulin resistance 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 68  Insulin secretion 
 6 genes, 2 drugs (DrugBank), 13 diseases shown 		  [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM3   D08441   Propiverine   [1] 226 
 [1] SNAP25   D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 69  Kaposi sarcoma-associated herpesvirus infection 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 70  Legionellosis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 71  Leishmaniasis 
 2 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 72  Long-term potentiation 
 6 genes, 3 drugs (DrugBank), 55 diseases shown 		  [1] CACNA1C   D08441   Propiverine   [1] 226 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 73  Malaria 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 74  MAPK signaling pathway 
 15 genes, 7 drugs (DrugBank), 62 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] NGF   D09387   Tanezumab   [2] 226, 298 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 75  Metabolic pathways 
 5 genes, 4 drugs (DrugBank), 47 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [2] PTGS1, PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 76  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 77  Morphine addiction 
 1 gene, 3 drugs (DrugBank), 9 diseases shown 		  [1] OPRM1   D01340   Naloxone   [2] 6, 226 
 D08249 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 D01355   Tramadol   [5] 46, 70, 78, 226, 271 
 D08623 
 78  mTOR signaling pathway 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 79  Natural killer cell mediated cytotoxicity 
 6 genes, 4 drugs (DrugBank), 59 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 80  Necroptosis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 81  Neuroactive ligand-receptor interaction 
 21 genes, 12 drugs (DrugBank), 41 diseases shown 		  [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [3] ADRA2A, ADRA2B, ADRA2C   D00514   Dexmedetomidine   [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 
 D01205 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D08441   Propiverine   [1] 226 
 [1] NR3C1   D00385   Triamcinolone   [18] 6, 10, 13, 35, 40, 41, 42, 43, 44, 45, 46, 56, 70, 90, 96, 97, 226, 298 
 D00983 
 D00984 
 D00985 
 D06216 
 [3] OPRD1, OPRK1, OPRM1   D01340   Naloxone   [2] 6, 226 
 D08249 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 [1] OPRM1   D01355   Tramadol   [5] 46, 70, 78, 226, 271 
 D08623 
 [1] OXTR   D00089   Oxytocin   [4] 127, 193, 206, 226 
 [1] P2RX3   D11349   Gefapixant   [2] 85, 226 
 [1] TRPV1   D00250   Capsaicin   [6] 2, 6, 19, 86, 113, 226 
 82  Neurotrophin signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] NGF   D09387   Tanezumab   [2] 226, 298 
 83  NF-kappa B signaling pathway 
 2 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 84  NOD-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 85  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 86  Oocyte meiosis 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 87  Osteoclast differentiation 
 6 genes, 4 drugs (DrugBank), 59 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 88  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 89  Oxytocin signaling pathway 
 15 genes, 6 drugs (DrugBank), 61 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [1] OXTR   D00089   Oxytocin   [4] 127, 193, 206, 226 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 90  Pancreatic secretion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CHRM3   D08441   Propiverine   [1] 226 
 91  Pathogenic Escherichia coli infection 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 92  Pathways in cancer 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 93  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 94  Pertussis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 95  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 96  PI3K-Akt signaling pathway 
 3 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] CHRM1, CHRM2   D08441   Propiverine   [1] 226 
 [1] NGF   D09387   Tanezumab   [2] 226, 298 
 97  Platelet activation 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS1   D00813   Ketorolac   [2] 70, 226 
 D08104 
 98  Prolactin signaling pathway 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 99  Proteoglycans in cancer 
 2 genes, 3 drugs (DrugBank), 18 diseases shown 		  [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 100  Purine metabolism 
 3 genes, 3 drugs (DrugBank), 46 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 101  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] NGF   D09387   Tanezumab   [2] 226, 298 
 102  Ras signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] NGF   D09387   Tanezumab   [2] 226, 298 
 103  Regulation of actin cytoskeleton 
 5 genes, 1 drug (DrugBank), 1 disease shown 		  [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D08441   Propiverine   [1] 226 
 104  Regulation of lipolysis in adipocytes 
 5 genes, 4 drugs (DrugBank), 16 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [3] ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [2] PTGS1, PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 105  Renin secretion 
 12 genes, 6 drugs (DrugBank), 62 diseases shown 		  [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [3] ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 106  Retrograde endocannabinoid signaling 
 5 genes, 2 drugs (DrugBank), 2 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 107  Rheumatoid arthritis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 108  RIG-I-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 109  Salivary secretion 
 7 genes, 4 drugs (DrugBank), 15 diseases shown 		  [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [1] ADRB1   D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] ADRB3   D09535   Mirabegron   [3] 6, 13, 226 
 [1] CHRM3   D08441   Propiverine   [1] 226 
 110  Serotonergic synapse 
 7 genes, 4 drugs (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 [2] PTGS1, PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 [1] SLC6A4   D00809   Amitriptyline   [3] 78, 226, 299 
 D07448 
 D00816   Nortriptyline   [2] 6, 226 
 D08288 
 111  Shigellosis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 112  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 113  Sphingolipid signaling pathway 
 3 genes, 5 drugs (DrugBank), 25 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] OPRD1   D01340   Naloxone   [2] 6, 226 
 D08249 
 D03783   Oxycodone   [7] 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 114  Synaptic vesicle cycle 
 4 genes, 4 drugs (DrugBank), 18 diseases shown 		  [1] SLC6A1   D00332   Gabapentin   [7] 6, 13, 19, 70, 97, 226, 298 
 [2] SLC6A2, SLC6A4   D00809   Amitriptyline   [3] 78, 226, 299 
 D07448 
 D00816   Nortriptyline   [2] 6, 226 
 D08288 
 [1] SNAP25   D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 115  Systemic lupus erythematosus 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 116  T cell receptor signaling pathway 
 6 genes, 4 drugs (DrugBank), 59 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 117  Taste transduction 
 6 genes, 4 drugs (DrugBank), 15 diseases shown 		  [2] CACNA1C, CHRM3   D08441   Propiverine   [1] 226 
 [1] P2RX3   D11349   Gefapixant   [2] 85, 226 
 [3] SCN2A, SCN3A, SCN9A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 D00358   Lidocaine   [10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 118  TGF-beta signaling pathway 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 119  Th1 and Th2 cell differentiation 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 120  Th17 cell differentiation 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 121  Thermogenesis 
 1 gene, 2 drugs (DrugBank), 9 diseases shown 		  [1] ADRB3   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 D09535   Mirabegron   [3] 6, 13, 226 
 122  Thyroid hormone signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 123  Tight junction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CACNA1D   D08441   Propiverine   [1] 226 
 124  TNF signaling pathway 
 2 genes, 3 drugs (DrugBank), 16 diseases shown 		  [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 125  Toll-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 126  Toxoplasmosis 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 127  Tuberculosis 
 6 genes, 4 drugs (DrugBank), 59 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 128  Type I diabetes mellitus 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 129  Type II diabetes mellitus 
 3 genes, 3 drugs (DrugBank), 15 diseases shown 		  [2] CACNA1C, CACNA1D   D08441   Propiverine   [1] 226 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 130  Vascular smooth muscle contraction 
 7 genes, 2 drugs (DrugBank), 9 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00095   Epinephrine   [9] 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D08441   Propiverine   [1] 226 
 131  VEGF signaling pathway 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00813   Ketorolac   [2] 70, 226 
 D08104 
 132  Viral protein interaction with cytokine and cytokine receptor 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 
 133  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 134  Yersinia infection 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D03441   Certolizumab pegol   [6] 37, 46, 96, 97, 226, 271 

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