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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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72 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 2  African trypanosomiasis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 3  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 4  Allograft rejection 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 5  Alzheimer disease 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 6  Amoebiasis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 7  Amyotrophic lateral sclerosis (ALS) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 8  Antifolate resistance 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 9  Antigen processing and presentation 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 10  Apoptosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 11  Asthma 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 12  Autoimmune thyroid disease 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 13  C-type lectin receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 14  Cell adhesion molecules (CAMs) 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 15  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 16  Cytokine-cytokine receptor interaction 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 17  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 18  Drug metabolism - other enzymes 
 2 genes, 2 drugs (DrugBank), 34 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 19  Epstein-Barr virus infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 20  Fc epsilon RI signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 21  Fluid shear stress and atherosclerosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 22  Graft-versus-host disease 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 23  Hematopoietic cell lineage 
 2 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 24  Hepatitis B 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 25  Hepatitis C 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 26  Herpes simplex virus 1 infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 27  Human cytomegalovirus infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 28  Human immunodeficiency virus 1 infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 29  Human papillomavirus infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 30  Human T-cell leukemia virus 1 infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 31  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 32  IL-17 signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 33  Inflammatory bowel disease (IBD) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 34  Influenza A 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 35  Insulin resistance 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 36  Intestinal immune network for IgA production 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 37  Kaposi sarcoma-associated herpesvirus infection 
 1 gene, 1 drug (DrugBank), 24 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 38  Legionellosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 39  Leishmaniasis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 40  Malaria 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 41  MAPK signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 42  Metabolic pathways 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] DHODH   D00749   Leflunomide   [10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 43  mTOR signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 44  Natural killer cell mediated cytotoxicity 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 45  Necroptosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 46  Neuroactive ligand-receptor interaction 
 1 gene, 2 drugs (DrugBank), 53 diseases shown 		  [1] NR3C1   D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 47  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 48  NOD-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 49  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 50  Osteoclast differentiation 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 51  Pathogenic Escherichia coli infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 52  Pertussis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 53  Proteoglycans in cancer 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 54  Purine metabolism 
 2 genes, 2 drugs (DrugBank), 34 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 55  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] DHODH   D00749   Leflunomide   [10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 56  Rheumatoid arthritis 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 57  RIG-I-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 58  Shigellosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 59  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 60  Systemic lupus erythematosus 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 61  T cell receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 62  TGF-beta signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 63  TNF signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 64  Toll-like receptor signaling pathway 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 65  Toxoplasmosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 66  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 24 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 67  Tuberculosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 68  Type I diabetes mellitus 
 3 genes, 2 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 69  Type II diabetes mellitus 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 70  Viral myocarditis 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 71  Viral protein interaction with cytokine and cytokine receptor 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 72  Yersinia infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 

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