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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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133 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adherens junction 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 3  Adipocytokine signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 4  Adrenergic signaling in cardiomyocytes 
 9 genes, 8 drugs (DrugBank), 23 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00608   Doxazosin   [2] 57, 67 
 D07874 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 5  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 4 drugs (DrugBank), 18 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 6  Aldosterone synthesis and secretion 
 5 genes, 6 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 7  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] NR3C2   D00443   Spironolactone   [6] 58, 67, 86, 113, 218, 225 
 8  Alzheimer disease 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 9  Amphetamine addiction 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 10  AMPK signaling pathway 
 6 genes, 6 drugs (DrugBank), 55 diseases shown 		  [1] ADRA1A   D00608   Doxazosin   [2] 57, 67 
 D07874 
 [1] HMGCR   D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 11  Apelin signaling pathway 
 4 genes, 7 drugs (DrugBank), 54 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 12  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 13  Autophagy - animal 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 14  Autophagy - other 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 15  Axon guidance 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] ABL1, SRC   D03252   Bosutinib   [2] 2, 67 
 16  Bacterial invasion of epithelial cells 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 17  beta-Alanine metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] AOC3   D08044   Hydralazine   [1] 67 
 18  Bile secretion 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [1] HMGCR   D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 [1] NR1H4   D00734   Ursodeoxycholic acid   [12] 6, 8, 20, 67, 84, 93, 94, 95, 96, 97, 234, 299 
 19  Bladder cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 20  Breast cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 21  C-type lectin receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 22  Calcium signaling pathway 
 10 genes, 8 drugs (DrugBank), 23 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00608   Doxazosin   [2] 57, 67 
 D07874 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01173   Cilnidipine   [1] 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 23  cAMP signaling pathway 
 8 genes, 6 drugs (DrugBank), 15 diseases shown 		  [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 [3] SSTR1, SSTR2, SSTR5   D10147   Pasireotide   [3] 67, 74, 75 
 D07431   Somatostatin   [2] 67, 78 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 24  Carbohydrate digestion and absorption 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 25  Cardiac muscle contraction 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 26  Cell cycle 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 27  Cellular senescence 
 2 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 28  Central carbon metabolism in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 29  cGMP-PKG signaling pathway 
 9 genes, 8 drugs (DrugBank), 23 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00608   Doxazosin   [2] 57, 67 
 D07874 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 30  Chagas disease (American trypanosomiasis) 
 1 gene, 3 drugs (DrugBank), 8 diseases shown 		  [1] ACE   D08068   Imidapril   [1] 67 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 31  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 32  Choline metabolism in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 33  Cholinergic synapse 
 5 genes, 2 drugs (DrugBank), 4 diseases shown 		  [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01173   Cilnidipine   [1] 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 34  Chronic myeloid leukemia 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 35  Circadian entrainment 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 36  Circadian rhythm 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 37  Colorectal cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 38  Cortisol synthesis and secretion 
 5 genes, 6 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 39  Cushing syndrome 
 5 genes, 6 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 40  Dilated cardiomyopathy (DCM) 
 5 genes, 3 drugs (DrugBank), 6 diseases shown 		  [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 41  Dopaminergic synapse 
 3 genes, 2 drugs (DrugBank), 4 diseases shown 		  [3] CACNA1B, CACNA1C, CACNA1D   D01173   Cilnidipine   [1] 67 
 [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 42  EGFR tyrosine kinase inhibitor resistance 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 43  Endocrine resistance 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 44  Endocytosis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 45  Epithelial cell signaling in Helicobacter pylori infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 46  ErbB signaling pathway 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [2] ABL1, SRC   D03252   Bosutinib   [2] 2, 67 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 47  Estrogen signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 48  Fluid shear stress and atherosclerosis 
 3 genes, 2 drugs (DrugBank), 18 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 49  Focal adhesion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 50  FoxO signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 51  GABAergic synapse 
 6 genes, 3 drugs (DrugBank), 5 diseases shown 		  [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01173   Cilnidipine   [1] 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 52  Gap junction 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 53  Gastric acid secretion 
 1 gene, 3 drugs (DrugBank), 10 diseases shown 		  [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 D10147   Pasireotide   [3] 67, 74, 75 
 D07431   Somatostatin   [2] 67, 78 
 54  Gastric cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 55  Glioma 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 56  Glucagon signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 57  Glutamatergic synapse 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 58  Glycine, serine and threonine metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] AOC3   D08044   Hydralazine   [1] 67 
 59  GnRH secretion 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 60  GnRH signaling pathway 
 5 genes, 3 drugs (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 61  Growth hormone synthesis, secretion and action 
 9 genes, 7 drugs (DrugBank), 44 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [4] SSTR1, SSTR2, SSTR3, SSTR5   D10147   Pasireotide   [3] 67, 74, 75 
 D07431   Somatostatin   [2] 67, 78 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 62  Hepatitis B 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 63  Hepatocellular carcinoma 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 64  Herpes simplex virus 1 infection 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 65  HIF-1 signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 66  Human cytomegalovirus infection 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 67  Human immunodeficiency virus 1 infection 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 68  Human papillomavirus infection 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 69  Huntington disease 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 70  Hypertrophic cardiomyopathy (HCM) 
 7 genes, 6 drugs (DrugBank), 24 diseases shown 		  [1] ACE   D08068   Imidapril   [1] 67 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 71  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 72  Insulin resistance 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 73  Insulin secretion 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 74  Insulin signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 75  JAK-STAT signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 76  Kaposi sarcoma-associated herpesvirus infection 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 77  Long-term potentiation 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1C   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 78  Longevity regulating pathway 
 4 genes, 4 drugs (DrugBank), 51 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 79  Longevity regulating pathway - multiple species 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 80  MAPK signaling pathway 
 5 genes, 2 drugs (DrugBank), 4 diseases shown 		  [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01173   Cilnidipine   [1] 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 81  Metabolic pathways 
 3 genes, 3 drugs (DrugBank), 10 diseases shown 		  [1] AOC3   D08044   Hydralazine   [1] 67 
 [1] HMGCR   D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 [1] UGCG   D11633   Venglustat   [2] 19, 67 
 82  MicroRNAs in cancer 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 83  Mitophagy - animal 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 84  Morphine addiction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CACNA1B   D01173   Cilnidipine   [1] 67 
 85  mTOR signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 86  Neuroactive ligand-receptor interaction 
 11 genes, 11 drugs (DrugBank), 29 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00608   Doxazosin   [2] 57, 67 
 D07874 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [1] AVPR2   D04752   Lixivaptan   [1] 67 
 D01213   Tolvaptan   [3] 67, 72, 225 
 [5] SSTR1, SSTR2, SSTR3, SSTR4, SSTR5   D07431   Somatostatin   [2] 67, 78 
 [4] SSTR1, SSTR2, SSTR3, SSTR5   D10147   Pasireotide   [3] 67, 74, 75 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 87  Neurotrophin signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 88  Nicotine addiction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CACNA1B   D01173   Cilnidipine   [1] 67 
 89  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 90  Osteoclast differentiation 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 91  Oxytocin signaling pathway 
 7 genes, 4 drugs (DrugBank), 21 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 92  Pancreatic cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 93  Pathogenic Escherichia coli infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 94  Pathways in cancer 
 4 genes, 8 drugs (DrugBank), 53 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 95  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 96  Phenylalanine metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] AOC3   D08044   Hydralazine   [1] 67 
 97  Phospholipase D signaling pathway 
 3 genes, 8 drugs (DrugBank), 48 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [1] AVPR2   D04752   Lixivaptan   [1] 67 
 D01213   Tolvaptan   [3] 67, 72, 225 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 98  PI3K-Akt signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 99  Platelet activation 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 100  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 101  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 102  Prostate cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 103  Proteoglycans in cancer 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 104  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 105  Ras signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 106  Regulation of actin cytoskeleton 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 107  Regulation of lipolysis in adipocytes 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 108  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 109  Renin secretion 
 7 genes, 10 drugs (DrugBank), 25 diseases shown 		  [1] ACE   D08068   Imidapril   [1] 67 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 110  Renin-angiotensin system 
 2 genes, 7 drugs (DrugBank), 21 diseases shown 		  [1] ACE   D08068   Imidapril   [1] 67 
 D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 111  Retrograde endocannabinoid signaling 
 5 genes, 2 drugs (DrugBank), 4 diseases shown 		  [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01173   Cilnidipine   [1] 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 112  Salivary secretion 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00608   Doxazosin   [2] 57, 67 
 D07874 
 [1] ADRB1   D00634   Bisoprolol   [3] 67, 86, 113 
 D02342 
 113  Serotonergic synapse 
 5 genes, 2 drugs (DrugBank), 4 diseases shown 		  [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S   D01173   Cilnidipine   [1] 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 114  Shigellosis 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [2] ABL1, SRC   D03252   Bosutinib   [2] 2, 67 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 115  Sphingolipid metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] UGCG   D11633   Venglustat   [2] 19, 67 
 116  Synaptic vesicle cycle 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CACNA1B   D01173   Cilnidipine   [1] 67 
 117  Taste transduction 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1C   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 118  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] HMGCR   D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 119  Th17 cell differentiation 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 120  Thermogenesis 
 4 genes, 4 drugs (DrugBank), 51 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 121  Thyroid cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 122  Thyroid hormone signaling pathway 
 2 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 123  Tight junction 
 4 genes, 4 drugs (DrugBank), 21 diseases shown 		  [1] CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 124  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 125  Tuberculosis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 126  Type II diabetes mellitus 
 4 genes, 4 drugs (DrugBank), 38 diseases shown 		  [3] CACNA1B, CACNA1C, CACNA1D   D01173   Cilnidipine   [1] 67 
 [2] CACNA1C, CACNA1D   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 127  Tyrosine metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] AOC3   D08044   Hydralazine   [1] 67 
 128  Vascular smooth muscle contraction 
 8 genes, 7 drugs (DrugBank), 22 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00608   Doxazosin   [2] 57, 67 
 D07874 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00627   Telmisartan   [2] 66, 67 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00615   Amlodipine   [4] 51, 65, 67, 298 
 D02914 
 D07450 
 D01173   Cilnidipine   [1] 67 
 129  Vasopressin-regulated water reabsorption 
 1 gene, 2 drugs (DrugBank), 3 diseases shown 		  [1] AVPR2   D04752   Lixivaptan   [1] 67 
 D01213   Tolvaptan   [3] 67, 72, 225 
 130  VEGF signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 131  Viral carcinogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 132  Viral myocarditis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 133  Yersinia infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 

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