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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1ACETYLSALICYLIC ACID1件: Acetylsalicylic acid1件: Aspirin 💬2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬4件: 13, 46, 51, 210 💬
2ACT-064992----5件: 51, 85, 86, 88, 210 💬
3Administration of an ACE-inhibitor or not----1件: 210 💬
4Aesculus Hippocastanum / Horse Chestnut1件: Horse chestnut1件: Horse chestnut 💬--1件: 210 💬
5Ambrisentan1件: Ambrisentan1件: Ambrisentan 💬1件: EDNRA 💬7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬7件: 51, 84, 85, 86, 88, 210, 211 💬
6Arginine1件: Arginine1件: Arginine 💬--11件: 46, 58, 67, 78, 96, 97, 98, 113, 210, 251, 299 💬
7Aspirin1件: Acetylsalicylic acid1件: Aspirin 💬2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬12件: 13, 22, 46, 49, 51, 58, 64, 86, 113, 158, 210, 231 💬
8Autologous cardiac stem cells (JRM-001)----2件: 210, 211 💬
9Autologous Tissue-Engineered Vascular Graft----1件: 210 💬
10BAY 59-7939----1件: 210 💬
11Bosentan1件: Bosentan2件: Bosentan ,
Bosentan 💬		2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
12Cardiac progenitor cell infusion----2件: 210, 211 💬
13Carvedilol1件: Carvedilol1件: Carvedilol 💬5件: ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬		13件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 57, 86, 113, 210 💬
14Colchicine1件: Colchicine1件: Colchicine 💬9件: TUBB,
TUBB1,
TUBB2A,
TUBB2B,
TUBB3,
TUBB4A,
TUBB4B,
TUBB6,
TUBB8 💬		10件: Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection 💬7件: 2, 42, 46, 56, 93, 210, 266 💬
15Digoxin1件: Digoxin1件: Digoxin 💬4件: ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬		18件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 8, 46, 210 💬
16Enalapril1件: Enalapril1件: Enalapril 💬1件: ACE 💬6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬6件: 19, 46, 66, 113, 210, 222 💬
17Eplerenone1件: Eplerenone1件: Eplerenone 💬1件: NR3C2 💬1件: Aldosterone-regulated sodium reabsorption 💬4件: 75, 113, 210, 215 💬
18Horse chestnut1件: Horse chestnut1件: Horse chestnut 💬--1件: 210 💬
19IPSC-CL----1件: 210 💬
20JNJ-39039039----1件: 210 💬
21Liothyronine1件: Liothyronine1件: Liothyronine 💬2件: THRA,
THRB 💬		2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬3件: 13, 210, 212 💬
22Liothyronine I 1312件: Liothyronine,
Liothyronine I-131		1件: Liothyronine 💬2件: THRA,
THRB 💬		2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬2件: 210, 212 💬
23Macitentan1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬5件: 51, 85, 86, 88, 210 💬
24MPC----2件: 210, 211 💬
25Mysildecard----1件: 210 💬
26MZ101----1件: 210 💬
27NITRIC OXIDE1件: Nitric Oxide1件: Nitric oxide 💬--7件: 85, 86, 88, 210, 251, 294, 299 💬
28Normal Saline----18件: 6, 13, 17, 22, 36, 46, 49, 60, 70, 94, 96, 210, 211, 226, 271, 276, 296, 299 💬
29ODSH at 0.125 mg/kg/h----1件: 210 💬
30ODSH at 0.250 mg/kg/h----1件: 210 💬
31ODSH at 0.375 mg/kg/h----1件: 210 💬
32Opsumit1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 86, 88, 210 💬
33Opsumit®1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 86, 88, 210 💬
34Rexlemestrocel-L----2件: 210, 211 💬
35Rivaroxaban1件: Rivaroxaban1件: Rivaroxaban 💬1件: F10 💬1件: Complement and coagulation cascades 💬4件: 46, 49, 91, 210 💬
36SCRM001_TEVG----1件: 210 💬
37Sildenafil1件: Sildenafil1件: Sildenafil 💬1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
38Sildenafil by injection1件: Sildenafil1件: Sildenafil 💬1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 210 💬
39Spironolactone1件: Spironolactone1件: Spironolactone 💬1件: NR3C2 💬1件: Aldosterone-regulated sodium reabsorption 💬8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
40Spironolactone (drug)1件: Spironolactone1件: Spironolactone 💬1件: NR3C2 💬1件: Aldosterone-regulated sodium reabsorption 💬1件: 210 💬
41Sugar pill----8件: 5, 6, 49, 67, 70, 86, 206, 210 💬
42Tadalafil1件: Tadalafil1件: Tadalafil 💬1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬7件: 6, 51, 75, 84, 86, 113, 210 💬
43Tadalafil Citrate1件: Tadalafil1件: Tadalafil 💬1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 210 💬
44Tracleer1件: Bosentan2件: Bosentan ,
Bosentan 💬		2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬8件: 13, 51, 84, 85, 86, 88, 210, 211 💬
45Treprostinil1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬6件: 51, 84, 85, 86, 88, 210 💬
46Udenafil1件: Udenafil1件: Udenafil 💬1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬2件: 86, 210 💬
47Vasopressin1件: Vasopressin1件: Vasopressin 💬3件: AVPR1A,
AVPR1B,
AVPR2 💬		5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬1件: 210 💬
48Vasopressin, Arginine2件: Arginine,
Vasopressin		2件: Vasopressin ,
Arginine 💬		3件: AVPR1A,
AVPR1B,
AVPR2 💬		5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬1件: 210 💬
49Vitamin C1件: Ascorbic acid1件: Ascorbic acid 💬--6件: 10, 192, 206, 210, 211, 212 💬
50Xarelto1件: Rivaroxaban1件: Rivaroxaban 💬1件: F10 💬1件: Complement and coagulation cascades 💬2件: 49, 210 💬