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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1ACTIMMUNE1件: Interferon gamma-1b1件: Interferon gamma-1b 💬2件: IFNGR1,
IFNGR2 💬		18件: Chagas disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬1件: 326 💬
2Actimmune Registry1件: Interferon gamma-1b1件: Interferon gamma-1b 💬2件: IFNGR1,
IFNGR2 💬		18件: Chagas disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬1件: 326 💬
3AP1903----3件: 60, 285, 326 💬
4AP1903 A594----3件: 60, 285, 326 💬
5BPX-501----3件: 60, 285, 326 💬
6BPX-501 cells----3件: 60, 285, 326 💬
7BPX-501 T cells----4件: 65, 284, 285, 326 💬
8Busulfan1件: Busulfan1件: Busulfan 💬--13件: 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326 💬
9Busulfan, Cyclophosphamide, Thymoglobulin, Fludarabine (Conditioning regimen)4件: Antithymocyte immunoglobulin (rabbit),
Busulfan,
Cyclophosphamide,
Fludarabine		4件: Busulfan ,
Cyclophosphamide ,
Cyclophosphamide ,
Fludarabine 💬		1件: RRM1 💬6件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬1件: 326 💬
10Calcitriol1件: Calcitriol1件: Calcitriol 💬1件: VDR 💬5件: Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
11CALD HR-D (High-Risk, Regimen C)----5件: 19, 20, 125, 234, 326 💬
12CALD HR-D (High-Risk, Regimen D)----5件: 19, 20, 125, 234, 326 💬
13CALD SR-A (Standard-Risk, Regimen A)----5件: 19, 20, 125, 234, 326 💬
14CALD SR-B (Standard-Risk, Regimen B)----5件: 19, 20, 125, 234, 326 💬
15Campath1件: Alemtuzumab1件: Alemtuzumab 💬1件: CD52 💬-12件: 19, 20, 49, 51, 60, 62, 65, 164, 234, 283, 285, 326 💬
16Campath, Busulfan, Clofarabine2件: Busulfan,
Clofarabine		2件: Busulfan ,
Clofarabine 💬		3件: POLA1,
POLA2,
RRM1 💬		7件: DNA replication, Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬1件: 326 💬
17Campath-1H1件: Alemtuzumab1件: Alemtuzumab 💬1件: CD52 💬-6件: 19, 20, 60, 234, 285, 326 💬
18CD34+ enriched, T Cell Depleted donor stem cell product----1件: 326 💬
19Clofarabine1件: Clofarabine1件: Clofarabine 💬3件: POLA1,
POLA2,
RRM1 💬		7件: DNA replication, Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬5件: 19, 20, 60, 234, 326 💬
20Cyclophosphamide1件: Cyclophosphamide2件: Cyclophosphamide ,
Cyclophosphamide 💬		--44件: 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 274, 283, 284, 285, 288, 326, 331 💬
21Cyclophosphamide 301件: Cyclophosphamide2件: Cyclophosphamide ,
Cyclophosphamide 💬		--3件: 65, 285, 326 💬
22Cyclophosphamide 401件: Cyclophosphamide2件: Cyclophosphamide ,
Cyclophosphamide 💬		--3件: 65, 285, 326 💬
23Cyclosporin1件: Cyclosporine1件: Cyclosporine 💬5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬17件: 38, 46, 49, 50, 53, 56, 60, 62, 63, 93, 95, 97, 113, 164, 222, 274, 326 💬
24Cyclosporin, Methotrexate (GVHD prophylaxis)2件: Cyclosporine,
Methotrexate		2件: Methotrexate ,
Cyclosporine 💬		7件: DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		38件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬1件: 326 💬
25Fludarabine1件: Fludarabine1件: Fludarabine 💬1件: RRM1 💬6件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬19件: 11, 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬
26Fludarabine monophosphate1件: Fludarabine1件: Fludarabine 💬1件: RRM1 💬6件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬3件: 65, 284, 326 💬
27Hematopoetic Stem Cell Transplantation----5件: 19, 65, 120, 160, 326 💬
28IMD----5件: 19, 20, 125, 234, 326 💬
29IMD Preparative Regimen----5件: 19, 20, 125, 234, 326 💬
30Interferon Gamma1件: Interferon Gamma---8件: 18, 65, 85, 107, 228, 299, 301, 326 💬
31INTERFERON GAMMA-1B2件: Interferon Gamma,
Interferon gamma-1b		1件: Interferon gamma-1b 💬2件: IFNGR1,
IFNGR2 💬		18件: Chagas disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬7件: 18, 65, 85, 228, 299, 301, 326 💬
32Methotrexate1件: Methotrexate1件: Methotrexate 💬2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
33Osteopetrosis Haploidentical Only Preparative Regimen----5件: 19, 20, 125, 234, 326 💬
34Osteopetrosis Only Preparative Regimen----5件: 19, 20, 125, 234, 326 💬
35RhPTH1件: Parathyroid hormone1件: Parathyroid hormone 💬2件: PTH1R,
PTH2R 💬		3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬3件: 70, 235, 326 💬
36Rimiducid1件: Rimiducid1件: Rimiducid 💬1件: CASP9 💬35件: Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Apoptosis - multiple species, Colorectal cancer, Endometrial cancer, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Huntington disease, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Lipid and atherosclerosis, Measles, Non-small cell lung cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parkinson disease, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platinum drug resistance, Prion disease, Prostate cancer, Small cell lung cancer, Thyroid hormone signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Viral myocarditis, p53 signaling pathway 💬6件: 19, 60, 65, 284, 285, 326 💬
37Rivogenlecleucel----4件: 19, 60, 285, 326 💬
38Rivogenleucleucel----3件: 60, 285, 326 💬
39Stem Cell Transplantation----10件: 13, 19, 20, 46, 65, 90, 125, 164, 234, 326 💬
40Systemic chemotherapy and antibodies----2件: 62, 326 💬
41Thymoglobulin1件: Antithymocyte immunoglobulin (rabbit)---7件: 36, 51, 60, 65, 96, 285, 326 💬