Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Acetate 1件: Acetate---41件: 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299 💬
2 Albendazole 2件: Albendazole; Eskazole1件: Albendazole 💬 --12件: 5, 6, 7, 13, 28, 51, 67, 86, 96, 97, 114, 127 💬
3 Amiloride 3件: AMILORIDE; Amiloride Hydrochloride; Midamor1件: Amiloride 💬 3件: SCNN1A,
SCNN1B,
SCNN1G 💬 		2件: Aldosterone-regulated sodium reabsorption, Taste transduction 💬4件: 13, 67, 225, 299 💬
4 Aminohippuric acid 1件: Aminohippurate1件: Aminohippuric acid 💬 --4件: 49, 53, 67, 86 💬
5 Amlodipine 1件: AMLODIPINE1件: Amlodipine 💬 4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 13, 51, 67, 298 💬
6 Arginine 6件: Arginina; Arginine; L-Arg; L-Arginin; L-arginine; R-Gene1件: Arginine 💬 --12件: 46, 58, 65, 67, 78, 96, 97, 98, 113, 210, 251, 299 💬
7 Aspartame 0件: 1件: Aspartame 💬 2件: TAS1R2,
TAS1R3 💬 		2件: Carbohydrate digestion and absorption, Taste transduction 💬4件: 6, 13, 67, 86 💬
8 Bardoxolone 1件: Bardoxolone1件: Bardoxolone 💬 --7件: 66, 67, 84, 85, 86, 218, 222 💬
9 Bardoxolone methyl 1件: Bardoxolone methyl1件: Bardoxolone methyl 💬 --7件: 66, 67, 84, 85, 86, 218, 222 💬
10 Bendroflumethiazide 1件: BENDROFLUMETHIAZIDE1件: Bendroflumethiazide 💬 1件: SLC12A3 💬 -1件: 67 💬
11 Bisoprolol 2件: BISOPROLOL; Bisoprolol Fumarate1件: Bisoprolol 💬 1件: ADRB1 💬 11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 58, 67, 86, 113 💬
12 Bosutinib 1件: BOSUTINIB1件: Bosutinib 💬 2件: ABL1,
SRC 💬 		49件: Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, C-type lectin receptor signaling pathway, Cell cycle, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, GnRH signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Prolactin signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬2件: 2, 67 💬
13 Candesartan 1件: Candesartan1件: Candesartan 💬 1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬2件: 58, 67 💬
14 Candesartan cilexetil 1件: CANDESARTAN1件: Candesartan cilexetil 💬 1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 67 💬
15 Chloride ion 1件: Chloride---28件: 6, 11, 13, 14, 34, 41, 46, 50, 51, 53, 60, 67, 70, 96, 97, 107, 127, 168, 171, 193, 227, 228, 251, 288, 296, 297, 299, 338 💬
16 Cilnidipine 1件: Cilnidipine1件: Cilnidipine 💬 5件: CACNA1B,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		41件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Morphine addiction, Nicotine addiction, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 67 💬
17 Curcumin 1件: Curcumin---10件: 2, 13, 46, 67, 74, 94, 96, 97, 139, 299 💬
18 Dapagliflozin 2件: Dapagliflozin; Forxiga1件: Dapagliflozin 💬 1件: SLC5A2 💬 -7件: 19, 49, 66, 67, 86, 88, 222 💬
19 Doxazosin 2件: CARDURA; Doxazosin1件: Doxazosin 💬 3件: ADRA1A,
ADRA1B,
ADRA1D 💬 		7件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬2件: 57, 67 💬
20 Emodin 1件: Emodin---1件: 67 💬
21 Empagliflozin 2件: Empagliflozin; Jardiance1件: Empagliflozin 💬 1件: SLC5A2 💬 -6件: 58, 65, 67, 72, 97, 257 💬
22 Everolimus 4件: Afinitor; Certican; Everolimus; Votubia1件: Everolimus 💬 1件: MTOR 💬 51件: AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
23 Hydralazine 1件: Hydralazine1件: Hydralazine 💬 1件: AOC3 💬 5件: Glycine, serine and threonine metabolism, Metabolic pathways, Phenylalanine metabolism, Tyrosine metabolism, beta-Alanine metabolism 💬1件: 67 💬
24 Hydrochlorothiazide 2件: Esidrix; Hydrochlorothiazide1件: Hydrochlorothiazide 💬 1件: SLC12A3 💬 -4件: 13, 67, 225, 235 💬
25 Imidapril 1件: Imidapril1件: Imidapril 💬 1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬1件: 67 💬
26 Iohexol 2件: Iohexol; OMNIPAQUE1件: Iohexol 💬 --3件: 19, 67, 222 💬
27 L-arginine 1件: L-arginine1件: Arginine 💬 --8件: 46, 67, 78, 96, 97, 98, 113, 299 💬
28 Lanreotide 3件: Lanreotide; LANREOTIDE ACETATE; Somatuline Autogel---4件: 67, 73, 85, 298 💬
29 Leuprolide 3件: Leuprolide; Leuprolide acetate depot; Leuprorelin---6件: 1, 2, 3, 51, 67, 76 💬
30 Lisinopril 2件: Lisinopril; Zestril2件: Lisinopril ,
Lisinopril 💬 		1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬7件: 19, 46, 49, 66, 67, 113, 222 💬
31 Lixivaptan 1件: Lixivaptan1件: Lixivaptan 💬 1件: AVPR2 💬 3件: Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬1件: 67 💬
32 Losartan 3件: Cozaar; Losartan; LOSARTAN POTASSIUM1件: Losartan 💬 1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬17件: 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
33 Metformin 5件: Metformin; Metformin HCl; Metformin hydrochloride; Metformina; Metformine1件: Metformin 💬 2件: PRKAA1,
PRKAA2 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
34 Nicotinamide 3件: Multivitamin; Niacinamide; Nicotinamide1件: Niacinamide 💬 --10件: 2, 5, 6, 18, 49, 67, 97, 107, 162, 191 💬
35 Nitrate 1件: Nitrate1件: Nitric acid 💬 --4件: 58, 67, 113, 299 💬
36 Octreotide 3件: Octreotide; OCTREOTIDE ACETATE; Sandostatin LAR1件: Octreotide 💬 1件: SSTR2 💬 4件: Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬7件: 67, 75, 84, 85, 89, 193, 227 💬
37 Pasireotide 3件: Pasireotida; PASIREOTIDE; SIGNIFOR1件: Pasireotide 💬 4件: SSTR1,
SSTR2,
SSTR3,
SSTR5 💬 		4件: Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬3件: 67, 74, 75 💬
38 Pioglitazone 1件: Pioglitazone1件: Pioglitazone 💬 1件: PPARG 💬 11件: AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
39 Potassium 1件: Potassium1件: Potassium 💬 --13件: 36, 46, 66, 67, 88, 93, 94, 98, 115, 167, 179, 215, 235 💬
40 Pravastatin 2件: Pravastatin; Pravastatin sodium1件: Pravastatin 💬 1件: HMGCR 💬 4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬9件: 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
41 Ramipril 1件: RAMIPRIL1件: Ramipril 💬 1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬7件: 46, 49, 66, 67, 113, 218, 257 💬
42 Sirolimus 3件: Rapamune; Rapamycin; Sirolimus1件: Sirolimus 💬 1件: MTOR 💬 51件: AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬40件: 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
43 Sodium chloride 6件: Lactated Ringers; Natriumchlorid; REBIF; SALINE; Sodium chloride; Sporanox1件: Sodium chloride 💬 --20件: 6, 11, 13, 14, 34, 41, 46, 50, 51, 53, 60, 67, 70, 96, 168, 193, 227, 228, 288, 299 💬
44 Sodium citrate 1件: Sodium citrate2件: Sodium citrate hydrate ,
Sodium citrate 💬 		--4件: 67, 214, 215, 235 💬
45 Somatostatin 1件: Somatostatin1件: Somatostatin 💬 5件: SSTR1,
SSTR2,
SSTR3,
SSTR4,
SSTR5 💬 		4件: Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬2件: 67, 78 💬
46 Spironolactone 1件: Spironolactone1件: Spironolactone 💬 1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
47 Telmisartan 1件: Telmisartan1件: Telmisartan 💬 1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬2件: 66, 67 💬
48 Tesevatinib 1件: Tesevatinib1件: Tesevatinib 💬 5件: EGFR,
EPHB4,
ERBB2,
FLT4,
KDR 💬 		53件: Adherens junction, Axon guidance, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Platinum drug resistance, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Tight junction, VEGF signaling pathway 💬1件: 67 💬
49 Tilarginine 1件: NG-Monomethyl-L-arginine---1件: 67 💬
50 Tolvaptan 3件: Jinarc; Samsca; Tolvaptan1件: Tolvaptan 💬 1件: AVPR2 💬 3件: Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬4件: 67, 72, 86, 225 💬
51 Tripterygium wilfordii whole 2件: Tripterygium; Tripterygium Wilfordii---8件: 46, 66, 67, 96, 162, 222, 224, 271 💬
52 Triptolide 1件: Triptolide---1件: 67 💬
53 Ursodeoxycholic acid 4件: UDCA; Ursodeoxycholic acid; Ursodiol; Ursofalk1件: Ursodiol 💬 1件: NR1H4 💬 1件: Bile secretion 💬14件: 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
54 Venglustat 2件: GENZ-682452; Venglustat1件: Venglustat 💬 1件: UGCG 💬 2件: Metabolic pathways, Sphingolipid metabolism 💬3件: 6, 19, 67 💬
55 Water 8件: AVONEX; ENBREL; Hiberix; INDOCYANINE GREEN; OMNITROPE; Sterile Water for Injection; Water; WATER FOR INJECTION1件: Water 💬 --21件: 2, 5, 6, 13, 17, 22, 35, 46, 53, 57, 63, 65, 67, 78, 84, 96, 97, 206, 226, 278, 299 💬