Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Acazicolcept
(Fc fusion protein of a human inducible T cell costimulator ligand variant immunoglobulin domain designed to inhibit simultaneously the CD28 and ICOS inflammation pathways)		1件: Acazicolcept1件: Acazicolcept 💬 2件: CD28,
ICOS 💬 		13件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Measles, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency, Rheumatoid arthritis, Systemic lupus erythematosus, T cell receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis 💬1件: 49 💬
2 Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells
(Allogeneic donor CD362 enriched human umbilical cord-derived mesenchymal stromal cells)		1件: Orbcel-C---2件: 94, 95 💬
3 CDP323
(CDP323)		1件: CDP323---1件: 13 💬
4 CDX-1135
(CDX 1135)		1件: CDX-1135---1件: 222 💬
5 Chenodeoxycholic acid
(CDCA)		2件: Chenodeoxycholic acid; Chenodiol1件: Chenodiol 💬 1件: NR1H4 💬 1件: Bile secretion 💬4件: 20, 96, 234, 263 💬
6 Cisplatin
(CDDP)		1件: Cisplatin1件: Cisplatin 💬 --1件: 28 💬
7 Citicoline
(CDP-colina)		0件: 2件: Citicoline ,
Citicoline sodium 💬 		--1件: 6 💬
8 Cladribine
(2-CdA)		3件: 2-CDA; Cladribina; Cladribine1件: Cladribine 💬 1件: RRM1 💬 4件: Drug metabolism - other enzymes, Glutathione metabolism, Purine metabolism, Pyrimidine metabolism 💬3件: 11, 13, 94 💬
9 Clindamycin
(7-CDL)		1件: Clindamycin4件: Clindamycin ,
Clindamycin phosphate ,
Clindamycin palmitate hydrochloride ,
Clindamycin hydrochloride 💬 		--2件: 46, 299 💬
10 Diltiazem 2件: Diltiazem; Diltiazem hydrochloride3件: Diltiazem hydrochloride (Dilt-CD, CARDIZEM CD, DILTIAZEM HCL CD),
Diltiazem malate ,
Diltiazem 💬 		4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 51, 58, 86, 88 💬
11 Efalizumab
(anti-CD11a)		1件: Efalizumab1件: Efalizumab 💬 1件: ITGAL 💬 12件: Cell adhesion molecules, Epstein-Barr virus infection, Human T-cell leukemia virus 1 infection, Leukocyte transendothelial migration, Malaria, Natural killer cell mediated cytotoxicity, Neutrophil extracellular trap formation, Rap1 signaling pathway, Regulation of actin cytoskeleton, Rheumatoid arthritis, Staphylococcus aureus infection, Viral myocarditis 💬9件: 11, 13, 37, 46, 53, 61, 95, 96, 221 💬
12 Elranatamab
(ANTI-CD3/ANTI-BCMA BISPECIFIC MONOCLONAL ANTIBODY PF-06863135)		1件: Elranatamab1件: Elranatamab 💬 1件: CD3E 💬 11件: Chagas disease, Epstein-Barr virus infection, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human immunodeficiency virus 1 infection, Measles, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation 💬1件: 28 💬
13 Hydroxypropyl betadex
(HP-beta-CD)		1件: 2-hydroxypropyl-BETA-cyclodextrin---1件: 19 💬
14 Inebilizumab 1件: Inebilizumab1件: Inebilizumab (Inebilizumab-cdon) 💬 1件: CD19 💬 5件: B cell receptor signaling pathway, Epstein-Barr virus infection, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Primary immunodeficiency 💬6件: 11, 13, 46, 49, 51, 300 💬
15 Leniolisib
(Cdz-173 free base)		2件: Leniolisib; Leniolisib phosphate2件: Leniolisib ,
Leniolisib phosphate 💬 		3件: PIK3CA_B_D,
PIK3CA_B_D,
PIK3CA_B_D 💬 		103件: AGE-RAGE signaling pathway in diabetic complications, AMPK signaling pathway, Acute myeloid leukemia, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Amoebiasis, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bacterial invasion of epithelial cells, Breast cancer, C-type lectin receptor signaling pathway, Carbohydrate digestion and absorption, Cellular senescence, Central carbon metabolism in cancer, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Cholinergic synapse, Chronic myeloid leukemia, Colorectal cancer, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Endometrial cancer, Epstein-Barr virus infection, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gastric cancer, Glioma, GnRH secretion, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, Influenza A, Inositol phosphate metabolism, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leukocyte transendothelial migration, Lipid and atherosclerosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Measles, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Phosphatidylinositol signaling system, Phospholipase D signaling pathway, Platelet activation, Prion disease, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Shigellosis, Signaling pathways regulating pluripotency of stem cells, Small cell lung cancer, Sphingolipid signaling pathway, Spinocerebellar ataxia, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, VEGF signaling pathway, Viral carcinogenesis, Yersinia infection, cAMP signaling pathway, mTOR signaling pathway 💬2件: 53, 65 💬
16 Linvoseltamab
(human IgG4-based anti-CD3 x anti-BCMA bispecific monoclonal antibody that binds to CD3 and BCMA)		1件: Linvoseltamab1件: Linvoseltamab 💬 1件: TNFRSF17 💬 2件: Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production 💬1件: 28 💬
17 Methylphenidate 2件: Methylphenidate; Methylphenidate hydrochloride2件: Methylphenidate hydrochloride (METADATE CD, METHYLPHENIDATE HYDROCHLORIDE CD),
Methylphenidate 💬 		2件: SLC6A2,
SLC6A3 💬 		8件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬7件: 6, 13, 34, 84, 113, 179, 206 💬
18 Mezagitamab
(Anti-Cd38 monoclonal antibody TAK-079)		1件: Mezagitamab1件: Mezagitamab 💬 1件: CD38 💬 6件: Calcium signaling pathway, Hematopoietic cell lineage, Nicotinate and nicotinamide metabolism, Oxytocin signaling pathway, Pancreatic secretion, Salivary secretion 💬2件: 63, 66 💬
19 Mozafancogene autotemcel
(Autologous CD34+-enriched HSPCs Transduced with Lentiviral Vector Carrying FANCA Gene RP-L102)		1件: RP-L102---1件: 285 💬
20 Muromonab
(Anti-CD3)		1件: ANTI-CD31件: Muromonab-CD3 (Muromonab-CD3) 💬 3件: CD3D,
CD3E,
CD3G 💬 		11件: Chagas disease, Epstein-Barr virus infection, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human immunodeficiency virus 1 infection, Measles, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation 💬3件: 60, 96, 97 💬
21 Obeticholic acid
(6-Ethyl-CDCA)		2件: 6-ecdca; Obeticholic acid1件: Obeticholic acid 💬 1件: NR1H4 💬 1件: Bile secretion 💬3件: 93, 265, 296 💬
22 Ofatumumab
(HuMax-CD20)		2件: Humax-CD20; Ofatumumab1件: Ofatumumab 💬 1件: MS4A1 💬 1件: Hematopoietic cell lineage 💬4件: 11, 13, 35, 46 💬
23 OTL-103
(Autologous CD34+ cells transfected with lentiviral vector containing the human WAS cDNA)		1件: OTL-103---1件: 65 💬
24 OTL-203
(Autologous CD34+ enriched cell population that contains hematopoietic stem and progenitor cells transduced ex-vivo using a lentiviral vector encoding alpha-L-iduronidase gene)		1件: OTL-203---1件: 19 💬
25 RP-L201
(Hematopoietic stem cells modified with a lentiviral vector containing the CD18 gene)		1件: RP-L201---1件: 65 💬
26 Strimvelis
(Autologous CD34+ enriched cell fraction that contains CD34+ cells transduced with retroviral vector that encodes for the human ADA cDNA sequence)		1件: Strimvelis---1件: 65 💬
27 TNB-383B
(Anti-BCMA/Anti-CD3 T-cell Engaging Bispecific Antibody ABBV-383)		1件: TNB-383B---1件: 28 💬
28 Toralizumab
(Anti-CD 154 human-mouse monoclonal antibody)		1件: ANTI-CD40L1件: Toralizumab 💬 1件: TNFSF5 💬 14件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules, Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Lipid and atherosclerosis, Malaria, NF-kappa B signaling pathway, Primary immunodeficiency, Systemic lupus erythematosus, T cell receptor signaling pathway, Toxoplasmosis, Viral myocarditis 💬1件: 63 💬
29 Zanolimumab
(Humax-cd4)		1件: Humax-CD41件: Zanolimumab 💬 1件: CD4 💬 14件: Antigen processing and presentation, Cell adhesion molecules, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Yersinia infection 💬1件: 46 💬