Target Gene/Pathway Pathway / Gene
Search results
| No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
|---|---|---|---|---|---|
| 1 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 2 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 3 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 4 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 5 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 6 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 7 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 8 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 9 | Aldosterone-regulated sodium reabsorption 💬 13 genes, 14 drugs (DrugBank) and 25 diseases |
NR3C2 1件: NR3C2 💬
|
Spironolactone Spironolactone 💬
| Spironolactone | 046 8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
|
| 10 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
HMGCR 1件: HMGCR 💬
|
Fluvastatin Fluvastatin 💬
| Fluvastatin | 079 3件: 79, 218, 222 💬
|
| 11 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 12 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 13 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 14 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 15 | Autophagy - animal 💬 13 genes, 18 drugs (DrugBank) and 62 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 16 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR 1件: HMGCR 💬
|
Fluvastatin Fluvastatin 💬
| Fluvastatin | 079 3件: 79, 218, 222 💬
|
| 17 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 18 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AGTR1 2件: AGTR1, EDNRA 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 19 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
EDNRA 1件: EDNRA 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 20 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 21 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
AGTR1 2件: AGTR1, EDNRA 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 22 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE 1件: ACE 💬
|
Benazepril Benazepril 💬
| Benazepril | 049 4件: 49, 57, 218, 224 💬
|
| 23 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE 1件: ACE 💬
|
Ramipril Ramipril 💬
| Ramipril | 046 7件: 46, 49, 66, 67, 113, 218, 257 💬
|
| 24 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
VDR 1件: VDR 💬
|
Paricalcitol Paricalcitol 💬
| Paricalcitol | 019 5件: 19, 66, 218, 238, 298 💬
|
| 25 | Circadian rhythm 💬 2 genes, 1 drug (DrugBank) and 25 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 26 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE 1件: ACE 💬
|
Benazepril Benazepril 💬
| Benazepril | 049 4件: 49, 57, 218, 224 💬
|
| 27 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE 1件: ACE 💬
|
Ramipril Ramipril 💬
| Ramipril | 046 7件: 46, 49, 66, 67, 113, 218, 257 💬
|
| 28 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 29 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 30 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 31 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 32 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 33 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 34 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE 1件: ACE 💬
|
Benazepril Benazepril 💬
| Benazepril | 049 4件: 49, 57, 218, 224 💬
|
| 35 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE 1件: ACE 💬
|
Ramipril Ramipril 💬
| Ramipril | 046 7件: 46, 49, 66, 67, 113, 218, 257 💬
|
| 36 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 37 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 38 | Endocrine and other factor-regulated calcium reabsorption 💬 8 genes, 27 drugs (DrugBank) and 55 diseases |
VDR 1件: VDR 💬
|
Paricalcitol Paricalcitol 💬
| Paricalcitol | 019 5件: 19, 66, 218, 238, 298 💬
|
| 39 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 40 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 41 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 42 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE 1件: ACE 💬
|
Benazepril Benazepril 💬
| Benazepril | 049 4件: 49, 57, 218, 224 💬
|
| 43 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE 1件: ACE 💬
|
Ramipril Ramipril 💬
| Ramipril | 046 7件: 46, 49, 66, 67, 113, 218, 257 💬
|
| 44 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 45 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 46 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 47 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 48 | Longevity regulating pathway - multiple species 💬 11 genes, 15 drugs (DrugBank) and 62 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 49 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
HMGCR 1件: HMGCR 💬
|
Fluvastatin Fluvastatin 💬
| Fluvastatin | 079 3件: 79, 218, 222 💬
|
| 50 | Mineral absorption 💬 8 genes, 13 drugs (DrugBank) and 41 diseases |
VDR 1件: VDR 💬
|
Paricalcitol Paricalcitol 💬
| Paricalcitol | 019 5件: 19, 66, 218, 238, 298 💬
|
| 51 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 52 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 53 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AGTR1 2件: AGTR1, EDNRA 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 54 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 55 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 56 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
VDR 1件: VDR 💬
|
Paricalcitol Paricalcitol 💬
| Paricalcitol | 019 5件: 19, 66, 218, 238, 298 💬
|
| 57 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 58 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AGTR1 2件: AGTR1, EDNRA 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 59 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 60 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 61 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 62 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE 1件: ACE 💬
|
Benazepril Benazepril 💬
| Benazepril | 049 4件: 49, 57, 218, 224 💬
|
| 63 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE 1件: ACE 💬
|
Ramipril Ramipril 💬
| Ramipril | 046 7件: 46, 49, 66, 67, 113, 218, 257 💬
|
| 64 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 65 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
AGTR1 2件: AGTR1, EDNRA 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 66 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE 1件: ACE 💬
|
Benazepril Benazepril 💬
| Benazepril | 049 4件: 49, 57, 218, 224 💬
|
| 67 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE 1件: ACE 💬
|
Ramipril Ramipril 💬
| Ramipril | 046 7件: 46, 49, 66, 67, 113, 218, 257 💬
|
| 68 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
AGTR1 1件: AGTR1 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|
| 69 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 70 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR 1件: HMGCR 💬
|
Fluvastatin Fluvastatin 💬
| Fluvastatin | 079 3件: 79, 218, 222 💬
|
| 71 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 72 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
PRKAA1 2件: PRKAA1, PRKAA2 💬
|
Metformin Metformin 💬
| Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
|
| 73 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR 1件: VDR 💬
|
Paricalcitol Paricalcitol 💬
| Paricalcitol | 019 5件: 19, 66, 218, 238, 298 💬
|
| 74 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 1件: AGTR1 💬
|
Valsartan Valsartan 💬
| Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬
|
| 75 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 2件: AGTR1, EDNRA 💬
|
Sparsentan Sparsentan 💬
| Sparsentan | 066 3件: 66, 218, 222 💬
|