Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Adipocytokine signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
2 Alcoholic liver disease 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
3 Aldosterone-regulated sodium reabsorption 💬
 1件: NR3C2 💬 Spironolactone 💬 Spironolactone 8件: 46, 58, 67, 86, 113, 210, 218, 225 💬 💬
4 Aldosterone-regulated sodium reabsorption 💬
 3件: SCNN1A, SCNN1B, SCNN1G 💬 Amiloride 💬 Amiloride 4件: 13, 67, 225, 299 💬 💬
5 Alzheimer disease 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
6 AMPK signaling pathway 💬
 1件: HMGCR 💬 Atorvastatin 💬 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬
7 AMPK signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
8 Apelin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
9 Arachidonic acid metabolism 💬
 2件: PTGS1, PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
10 Autophagy - animal 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
11 Bile secretion 💬
 1件: CA2 💬 Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬 💬
12 Bile secretion 💬
 1件: HMGCR 💬 Atorvastatin 💬 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬
13 C-type lectin receptor signaling pathway 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
14 cGMP-PKG signaling pathway 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
15 cGMP-PKG signaling pathway 💬
 1件: PDE5A 💬 Sildenafil 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬
16 Chemical carcinogenesis - DNA adducts 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
17 Circadian entrainment 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
18 Circadian rhythm 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
19 Collecting duct acid secretion 💬
 2件: ATP4A, ATP4B 💬 Omeprazole 💬 Omeprazole 14件:  6 ,  8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬 💬
20 Collecting duct acid secretion 💬
 1件: CA2 💬 Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬 💬
21 Complement and coagulation cascades 💬
 1件: F8 💬 Desmopressin 💬 Desmopressin 6件:  6 , 64, 72, 75, 225, 288 💬 💬
22 Fluid shear stress and atherosclerosis 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
23 FoxO signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
24 Gap junction 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
25 Gastric acid secretion 💬
 2件: ATP4A, ATP4B 💬 Omeprazole 💬 Omeprazole 14件:  6 ,  8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬 💬
26 Gastric acid secretion 💬
 1件: CA2 💬 Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬 💬
27 Glucagon signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
28 Human cytomegalovirus infection 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
29 Human papillomavirus infection 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
30 Hypertrophic cardiomyopathy 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
31 IL-17 signaling pathway 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
32 Insulin resistance 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
33 Insulin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
34 Kaposi sarcoma-associated herpesvirus infection 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
35 Leishmaniasis 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
36 Long-term depression 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
37 Longevity regulating pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
38 Longevity regulating pathway - multiple species 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
39 Metabolic pathways 💬
 2件: ATP4A, ATP4B 💬 Omeprazole 💬 Omeprazole 14件:  6 ,  8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬 💬
40 Metabolic pathways 💬
 13件: CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬 Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬 💬
41 Metabolic pathways 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
42 Metabolic pathways 💬
 1件: HMGCR 💬 Atorvastatin 💬 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬
43 Metabolic pathways 💬
 1件: PDE5A 💬 Sildenafil 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬
44 Metabolic pathways 💬
 2件: PTGS1, PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
45 MicroRNAs in cancer 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
46 mTOR signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
47 Neuroactive ligand-receptor interaction 💬
 1件: AVPR2 💬 Desmopressin 💬 Desmopressin 6件:  6 , 64, 72, 75, 225, 288 💬 💬
48 Neuroactive ligand-receptor interaction 💬
 1件: AVPR2 💬 Tolvaptan 💬 Tolvaptan 4件: 67, 72, 86, 225 💬 💬
49 NF-kappa B signaling pathway 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
50 Nitrogen metabolism 💬
 13件: CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬 Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬 💬
51 Non-alcoholic fatty liver disease 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
52 Ovarian steroidogenesis 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
53 Oxidative phosphorylation 💬
 2件: ATP4A, ATP4B 💬 Omeprazole 💬 Omeprazole 14件:  6 ,  8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬 💬
54 Oxytocin signaling pathway 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
55 Oxytocin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
56 Oxytocin signaling pathway 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
57 Pancreatic secretion 💬
 1件: CA2 💬 Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬 💬
58 Pathways in cancer 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
59 Pathways of neurodegeneration - multiple diseases 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
60 Phospholipase D signaling pathway 💬
 1件: AVPR2 💬 Desmopressin 💬 Desmopressin 6件:  6 , 64, 72, 75, 225, 288 💬 💬
61 Phospholipase D signaling pathway 💬
 1件: AVPR2 💬 Tolvaptan 💬 Tolvaptan 4件: 67, 72, 86, 225 💬 💬
62 PI3K-Akt signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
63 Platelet activation 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
64 Platelet activation 💬
 1件: PTGS1 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
65 Proximal tubule bicarbonate reclamation 💬
 2件: CA2, CA4 💬 Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬 💬
66 Purine metabolism 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
67 Purine metabolism 💬
 1件: PDE5A 💬 Sildenafil 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬
68 Regulation of lipolysis in adipocytes 💬
 2件: PTGS1, PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
69 Renin secretion 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
70 Retrograde endocannabinoid signaling 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
71 Salivary secretion 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
72 Serotonergic synapse 💬
 2件: PTGS1, PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
73 Small cell lung cancer 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
74 Taste transduction 💬
 3件: SCNN1A, SCNN1B, SCNN1G 💬 Amiloride 💬 Amiloride 4件: 13, 67, 225, 299 💬 💬
75 Terpenoid backbone biosynthesis 💬
 1件: HMGCR 💬 Atorvastatin 💬 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬
76 Thermogenesis 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
77 Tight junction 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
78 TNF signaling pathway 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬
79 Vascular smooth muscle contraction 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
80 Vasopressin-regulated water reabsorption 💬
 1件: AVPR2 💬 Desmopressin 💬 Desmopressin 6件:  6 , 64, 72, 75, 225, 288 💬 💬
81 Vasopressin-regulated water reabsorption 💬
 1件: AVPR2 💬 Tolvaptan 💬 Tolvaptan 4件: 67, 72, 86, 225 💬 💬
82 VEGF signaling pathway 💬
 1件: PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬 💬

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