Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Arachidonic acid metabolism 💬
1件: ALOX5 💬 Oxatomide 💬 Oxatomide 1件: 113 💬
2 Arachidonic acid metabolism 💬
1件: ALOX5 💬 Zileuton 💬 Zileuton 3件: 85, 160, 164 💬
3 Arachidonic acid metabolism 💬
3件: PTGES, PTGS1, PTGS2 💬 Aceclofenac 💬 Aceclofenac 1件: 46 💬
4 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Acetaminophen 💬 Acetaminophen 15件:  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
5 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Aspirin 💬 Acetylsalicylic acid 14件: 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
6 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Diclofenac 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
7 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Flurbiprofen 💬 Flurbiprofen 3件: 13, 21, 46 💬
8 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Ibuprofen 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
9 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬
10 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Ketoprofen 💬 Ketoprofen 1件: 46 💬
11 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Ketorolac 💬 Ketorolac 2件: 70, 226 💬
12 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Loxoprofen 💬 Loxoprofen 2件: 46, 271 💬
13 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Naproxen 💬 Naproxen 4件: 13, 46, 107, 271 💬
14 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Salsalate 💬 Salsalate 1件:  5  💬
15 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Sulindac 💬 Sulindac 1件: 206 💬
16 Arachidonic acid metabolism 💬
2件: PTGS1, PTGS2 💬 Tolfenamic acid 💬 Tolfenamic acid 1件:  5  💬
17 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Celecoxib 💬 Celecoxib 10件:  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
18 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Diflunisal 💬 Diflunisal 1件: 28 💬
19 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Etodolac 💬 Etodolac 1件: 46 💬
20 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Etoricoxib 💬 Etoricoxib 2件: 46, 271 💬
21 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Lumiracoxib 💬 Lumiracoxib 1件: 46 💬
22 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Meloxicam 💬 Meloxicam 4件: 46, 49, 271, 296 💬
23 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Nimesulide 💬 Nimesulide 1件: 46 💬
24 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Parecoxib 💬 Parecoxib 2件: 46, 271 💬
25 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Rofecoxib 💬 Rofecoxib 1件: 46 💬
26 Arachidonic acid metabolism 💬
1件: PTGS2 💬 Valdecoxib 💬 Valdecoxib 1件: 46 💬
27 Arginine and proline metabolism 💬
1件: MAOA 💬 Moclobemide 💬 Moclobemide 1件:  6  💬
28 Arginine and proline metabolism 💬
2件: MAOA, MAOB 💬 Iproniazid 💬 Iproniazid 1件:  6  💬
29 Arginine and proline metabolism 💬
2件: MAOA, MAOB 💬 Phenelzine 💬 Phenelzine 1件:  6  💬
30 Arginine and proline metabolism 💬
2件: MAOA, MAOB 💬 Phentermine 💬 Phentermine 1件: 97 💬
31 Arginine and proline metabolism 💬
1件: MAOB 💬 Rasagiline 💬 Rasagiline 6件:  2 ,  5 ,  6 , 17, 58, 66 💬
32 Arginine and proline metabolism 💬
1件: MAOB 💬 Rasagiline tartrate 💬 Rasagiline 6件:  2 ,  5 ,  6 , 17, 58, 66 💬
33 Arginine and proline metabolism 💬
1件: MAOB 💬 Safinamide 💬 Safinamide 2件:  6 , 17 💬
34 Arginine and proline metabolism 💬
1件: MAOB 💬 Selegiline 💬 Selegiline 1件:  6  💬
35 Arginine and proline metabolism 💬
1件: ODC1 💬 Eflornithine 💬 Eflornithine 1件: 65 💬
36 Arginine biosynthesis 💬
1件: CPS1 💬 Carglumic acid 💬 Carglumic acid 3件: 245, 246, 251 💬
37 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine 4件: 13, 51, 67, 298 💬
38 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine 1件: 67 💬
39 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem 3件: 51, 58, 86 💬
40 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine 1件:  6  💬
41 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine 2件: 70, 86 💬
42 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine 2件: 50, 81 💬
43 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine 1件: 90 💬
44 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline 2件: 58, 272 💬
45 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine 1件: 226 💬
46 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
47 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil 4件: 58, 96, 140, 167 💬
48 Arrhythmogenic right ventricular cardiomyopathy 💬
2件: CACNA2D1, CACNA2D2 💬 Mirogabalin 💬 Mirogabalin 1件: 70 💬
49 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Gabapentin 💬 Gabapentin 5件:  6 , 13, 19, 70, 298 💬
50 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Pregabalin 💬 Pregabalin 5件: 13, 36, 46, 70, 298 💬
51 Arrhythmogenic right ventricular cardiomyopathy 💬
1件: DMD 💬 Casimersen 💬 Casimersen 1件: 113 💬
52 Arrhythmogenic right ventricular cardiomyopathy 💬
1件: DMD 💬 Drisapersen 💬 Drisapersen 1件: 113 💬
53 Arrhythmogenic right ventricular cardiomyopathy 💬
1件: DMD 💬 Eteplirsen 💬 Eteplirsen 1件: 113 💬
54 Arrhythmogenic right ventricular cardiomyopathy 💬
1件: DMD 💬 Golodirsen 💬 Golodirsen 1件: 113 💬
55 Arrhythmogenic right ventricular cardiomyopathy 💬
1件: DMD 💬 Viltolarsen 💬 Viltolarsen 1件: 113 💬
56 Arrhythmogenic right ventricular cardiomyopathy 💬
1件: ITGA4 💬 Firategrast 💬 Firategrast 1件: 13 💬
57 Arrhythmogenic right ventricular cardiomyopathy 💬
1件: ITGA4 💬 Natalizumab 💬 Natalizumab 6件: 13, 15, 25, 46, 63, 96 💬
58 Arrhythmogenic right ventricular cardiomyopathy 💬
2件: ITGA4, ITGB7 💬 Abrilumab 💬 Abrilumab 2件: 96, 97 💬
59 Arrhythmogenic right ventricular cardiomyopathy 💬
2件: ITGA4, ITGB7 💬 Vedolizumab 💬 Vedolizumab 3件: 94, 96, 97 💬
60 Arrhythmogenic right ventricular cardiomyopathy 💬
1件: ITGB7 💬 Etrolizumab 💬 Etrolizumab 2件: 96, 97 💬
61 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 Amiodarone 💬 Amiodarone 2件: 28, 127 💬
62 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 Atenolol 💬 Atenolol 1件: 167 💬
63 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 Bisoprolol 💬 Bisoprolol 4件: 58, 67, 86, 113 💬
64 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 Celiprolol 💬 Celiprolol 1件: 168 💬
65 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 Dobutamine 💬 Dobutamine 4件: 57, 58, 86, 215 💬
66 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 Esmolol 💬 Esmolol 1件: 58 💬
67 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 Metoprolol 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
68 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 Nebivolol 💬 Nebivolol 4件: 17, 85, 113, 167 💬
69 Chemical carcinogenesis - receptor activation 💬
2件: ADRB1, ADRB2 💬 Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬
70 Chemical carcinogenesis - receptor activation 💬
2件: ADRB1, ADRB2 💬 Nadolol 💬 Nadolol 1件:  6  💬
71 Chemical carcinogenesis - receptor activation 💬
2件: ADRB1, ADRB2 💬 Timolol 💬 Timolol 2件: 157, 227 💬
72 Chemical carcinogenesis - receptor activation 💬
2件: ADRB1, ADRB2 💬 Timolol 💬 Timolol 2件: 157, 227 💬
73 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 Dipivefrin 💬 Dipivefrin 1件:  6  💬
74 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 Droxidopa 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬
75 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 Ephedrine 💬 Ephedrine 1件: 11 💬
76 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 Epinephrine 💬 Epinephrine 3件: 46, 70, 96 💬
77 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 Noradrenaline 💬 Norepinephrine 2件: 22, 296 💬
78 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
79 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 Pseudoephedrine 💬 Pseudoephedrine 1件: 17 💬
80 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 Clenbuterol 💬 Clenbuterol 5件:  1 ,  2 ,  6 , 13, 256 💬
81 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 Formoterol 💬 Formoterol 3件: 85, 228, 299 💬
82 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 Isoxsuprine 💬 Isoxsuprine 1件: 13 💬
83 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 Levosalbutamol 💬 Levosalbutamol 1件: 49 💬
84 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 Albuterol 💬 Salbutamol 12件:  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
85 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 Salmeterol 💬 Salmeterol 1件: 299 💬
86 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 Terbutaline 💬 Terbutaline 1件: 118 💬
87 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 Tulobuterol 💬 Tulobuterol 1件:  6  💬
88 Chemical carcinogenesis - receptor activation 💬
1件: ADRB3 💬 Mirabegron 💬 Mirabegron 4件:  6 , 13, 53, 226 💬
89 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Calusterone 💬 Calusterone 1件:  2  💬
90 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Flutamide 💬 Flutamide 1件: 81 💬
91 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Nandrolone 💬 Nandrolone 2件: 60, 85 💬
92 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate 2件: 60, 85 💬
93 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Oxandrolone 💬 Oxandrolone 2件: 211, 285 💬
94 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Stanozolol 💬 Stanozolol 1件: 60 💬
95 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Testosterone 💬 Testosterone 8件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
96 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Testosterone decanoate 💬 Testosterone decanoate 1件: 113 💬
97 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Testosterone enanthate 💬 Testosterone enanthate 1件: 113 💬
98 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate 1件: 113 💬
99 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Testosterone propionate 💬 Testosterone propionate 1件: 113 💬
100 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate 2件: 13, 60 💬
101 Chemical carcinogenesis - receptor activation 💬
3件: AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
102 Chemical carcinogenesis - receptor activation 💬
3件: AR, ESR1, PGR 💬 Danazol 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
103 Chemical carcinogenesis - receptor activation 💬
1件: BCL2 💬 Venetoclax 💬 Venetoclax 1件: 28 💬
104 Chemical carcinogenesis - receptor activation 💬
5件: CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine 1件: 67 💬
105 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine 4件: 13, 51, 67, 298 💬
106 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem 3件: 51, 58, 86 💬
107 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine 1件:  6  💬
108 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine 2件: 70, 86 💬
109 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine 2件: 50, 81 💬
110 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine 1件: 90 💬
111 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline 2件: 58, 272 💬
112 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine 1件: 226 💬
113 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
114 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil 4件: 58, 96, 140, 167 💬
115 Chemical carcinogenesis - receptor activation 💬
6件: CHRNA3, CHRNA4, CHRNA7, CHRNA9, CHRNB2, CHRNB4 💬 Nicotine 💬 Nicotine 3件:  6 , 13, 84 💬
116 Chemical carcinogenesis - receptor activation 💬
2件: CHRNA4, CHRNB2 💬 Varenicline 💬 Varenicline 3件:  6 , 18, 53 💬
117 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 Cetuximab 💬 Cetuximab 2件: 51, 86 💬
118 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 Erlotinib 💬 Erlotinib 1件: 94 💬
119 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬
120 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬
121 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
122 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 Neratinib 💬 Neratinib 1件: 34 💬
123 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
124 Chemical carcinogenesis - receptor activation 💬
1件: ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol 4件: 13, 46, 49, 299 💬
125 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Clomifene 💬 Clomifene 1件: 74 💬
126 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Estetrol 💬 Estetrol 1件: 53 💬
127 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Estetrol 💬 Estetrol 1件: 53 💬
128 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Estradiol 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
129 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate 1件: 65 💬
130 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Estriol 💬 Estriol 2件: 13, 227 💬
131 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol 2件: 13, 227 💬
132 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant 2件: 49, 86 💬
133 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Mestranol 💬 Mestranol 2件: 46, 49 💬
134 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Raloxifene 💬 Raloxifene 1件: 46 💬
135 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen 3件:  2 , 113, 227 💬
136 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, PGR 💬 Desogestrel 💬 Desogestrel 1件: 230 💬
137 Chemical carcinogenesis - receptor activation 💬
1件: JAK2 💬 Baricitinib 💬 Baricitinib 13件:  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
138 Chemical carcinogenesis - receptor activation 💬
1件: JAK2 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
139 Chemical carcinogenesis - receptor activation 💬
1件: JAK2 💬 Ruxolitinib 💬 Ruxolitinib 3件: 60, 65, 228 💬
140 Chemical carcinogenesis - receptor activation 💬
1件: JAK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
141 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
142 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
143 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 1件: 34 💬
144 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
145 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 4件:  2 , 34, 279, 280 💬
146 Chemical carcinogenesis - receptor activation 💬
1件: MTOR 💬 Everolimus 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
147 Chemical carcinogenesis - receptor activation 💬
1件: MTOR 💬 Sirolimus 💬 Sirolimus 40件:  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
148 Chemical carcinogenesis - receptor activation 💬
1件: MTOR 💬 Temsirolimus 💬 Temsirolimus 1件: 13 💬
149 Chemical carcinogenesis - receptor activation 💬
1件: NFKB1 💬 Iguratimod 💬 Iguratimod 5件: 46, 51, 53, 271, 300 💬
150 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Dydrogesterone 💬 Dydrogesterone 1件: 13 💬
151 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Levonorgestrel 💬 Levonorgestrel 1件: 13 💬
152 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Medroxyprogesterone acetate 💬 Medroxyprogesterone acetate 8件: 13, 35, 46, 49, 50, 51, 60, 107 💬
153 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Megestrol acetate 💬 Megestrol acetate 1件: 76 💬
154 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Mifepristone 💬 Mifepristone 1件: 75 💬
155 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Nomegestrol 💬 Nomegestrol 1件: 13 💬
156 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Nomegestrol acetate 💬 Nomegestrol acetate 1件: 13 💬
157 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Norethindrone 💬 Norethisterone 4件: 13, 46, 49, 299 💬
158 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Norgestimate 💬 Norgestimate 1件: 299 💬
159 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Progesterone 💬 Progesterone 2件: 76, 299 💬
160 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Ulipristal 💬 Ulipristal 1件: 10 💬
161 Chemical carcinogenesis - receptor activation 💬
1件: PIK3CA 💬 Alpelisib 💬 Alpelisib 1件: 138 💬
162 Chemical carcinogenesis - receptor activation 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
163 Chemical carcinogenesis - receptor activation 💬
1件: PIK3CD 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
164 Chemical carcinogenesis - receptor activation 💬
1件: PPARA 💬 Bezafibrate 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
165 Chemical carcinogenesis - receptor activation 💬
1件: PPARA 💬 Elafibranor 💬 Elafibranor 2件: 93, 94 💬
166 Chemical carcinogenesis - receptor activation 💬
1件: PPARA 💬 Fenofibrate 💬 Fenofibrate 6件:  8 , 79, 93, 94, 97, 265 💬
167 Chemical carcinogenesis - receptor activation 💬
1件: PPARA 💬 Pemafibrate 💬 Pemafibrate 1件: 93 💬
168 Chemical carcinogenesis - receptor activation 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
169 Chemical carcinogenesis - receptor activation 💬
1件: RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
170 Chemical carcinogenesis - receptor activation 💬
1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
171 Chemical carcinogenesis - receptor activation 💬
3件: RXRA, RXRB, RXRG 💬 Acitretin 💬 Acitretin 1件: 37 💬
172 Chemical carcinogenesis - receptor activation 💬
3件: RXRA, RXRB, RXRG 💬 Alitretinoin 💬 Alitretinoin 1件: 49 💬
173 Chemical carcinogenesis - receptor activation 💬
3件: RXRA, RXRB, RXRG 💬 Bexarotene 💬 Bexarotene 2件: 13, 75 💬
174 Chemical carcinogenesis - receptor activation 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
175 Chemical carcinogenesis - receptor activation 💬
1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
176 Chemical carcinogenesis - receptor activation 💬
1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
177 Chemical carcinogenesis - receptor activation 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬
178 Chemical carcinogenesis - receptor activation 💬
1件: TNFSF11 💬 Denosumab 💬 Denosumab 8件: 46, 50, 70, 93, 95, 96, 274, 299 💬
179 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Alfacalcidol 💬 Alfacalcidol 8件: 41, 46, 49, 50, 96, 107, 235, 238 💬
180 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Calcifediol 💬 Calcifediol 2件: 113, 299 💬
181 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Calcipotriene 💬 Calcipotriol 2件: 36, 51 💬
182 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Calcitriol 💬 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
183 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Cholecalciferol 💬 Cholecalciferol 24件:  6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬
184 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Dihydrotachysterol 💬 Dihydrotachysterol 2件:  6 , 85 💬
185 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Eldecalcitol 💬 Eldecalcitol 1件: 46 💬
186 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Ergocalciferol 💬 Ergocalciferol 6件: 46, 49, 84, 96, 97, 299 💬
187 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 Paricalcitol 💬 Paricalcitol 5件: 19, 66, 218, 238, 298 💬
188 Chemical carcinogenesis - receptor activation 💬
1件: VEGFA 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬
189 Chemical carcinogenesis - receptor activation 💬
1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 6件: 13, 34, 85, 87, 227, 280 💬
190 Chemical carcinogenesis - receptor activation 💬
1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
191 Glycosaminoglycan degradation 💬
1件: ARSB 💬 Galsulfase 💬 Galsulfase 1件: 19 💬
192 Lysosome 💬
1件: ARSB 💬 Galsulfase 💬 Galsulfase 1件: 19 💬
193 Metabolic pathways 💬
1件: ARSB 💬 Galsulfase 💬 Galsulfase 1件: 19 💬
194 Oocyte meiosis 💬
1件: AR 💬 Calusterone 💬 Calusterone 1件:  2  💬
195 Oocyte meiosis 💬
1件: AR 💬 Flutamide 💬 Flutamide 1件: 81 💬
196 Oocyte meiosis 💬
1件: AR 💬 Nandrolone 💬 Nandrolone 2件: 60, 85 💬
197 Oocyte meiosis 💬
1件: AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate 2件: 60, 85 💬
198 Oocyte meiosis 💬
1件: AR 💬 Oxandrolone 💬 Oxandrolone 2件: 211, 285 💬
199 Oocyte meiosis 💬
1件: AR 💬 Prasterone 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
200 Oocyte meiosis 💬
1件: AR 💬 Stanozolol 💬 Stanozolol 1件: 60 💬
201 Oocyte meiosis 💬
1件: AR 💬 Testosterone 💬 Testosterone 8件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
202 Oocyte meiosis 💬
1件: AR 💬 Testosterone decanoate 💬 Testosterone decanoate 1件: 113 💬
203 Oocyte meiosis 💬
1件: AR 💬 Testosterone enanthate 💬 Testosterone enanthate 1件: 113 💬
204 Oocyte meiosis 💬
1件: AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate 1件: 113 💬
205 Oocyte meiosis 💬
1件: AR 💬 Testosterone propionate 💬 Testosterone propionate 1件: 113 💬
206 Oocyte meiosis 💬
1件: AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate 2件: 13, 60 💬
207 Oocyte meiosis 💬
2件: AR, PGR 💬 Danazol 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
208 Pathways in cancer 💬
1件: AR 💬 Calusterone 💬 Calusterone 1件:  2  💬
209 Pathways in cancer 💬
1件: AR 💬 Flutamide 💬 Flutamide 1件: 81 💬
210 Pathways in cancer 💬
1件: AR 💬 Nandrolone 💬 Nandrolone 2件: 60, 85 💬
211 Pathways in cancer 💬
1件: AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate 2件: 60, 85 💬
212 Pathways in cancer 💬
1件: AR 💬 Oxandrolone 💬 Oxandrolone 2件: 211, 285 💬
213 Pathways in cancer 💬
1件: AR 💬 Stanozolol 💬 Stanozolol 1件: 60 💬
214 Pathways in cancer 💬
1件: AR 💬 Testosterone 💬 Testosterone 8件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
215 Pathways in cancer 💬
1件: AR 💬 Testosterone decanoate 💬 Testosterone decanoate 1件: 113 💬
216 Pathways in cancer 💬
1件: AR 💬 Testosterone enanthate 💬 Testosterone enanthate 1件: 113 💬
217 Pathways in cancer 💬
1件: AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate 1件: 113 💬
218 Pathways in cancer 💬
1件: AR 💬 Testosterone propionate 💬 Testosterone propionate 1件: 113 💬
219 Pathways in cancer 💬
1件: AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate 2件: 13, 60 💬
220 Pathways in cancer 💬
2件: AR, ESR1 💬 Danazol 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
221 Pathways in cancer 💬
3件: AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
222 Prostate cancer 💬
1件: AR 💬 Calusterone 💬 Calusterone 1件:  2  💬
223 Prostate cancer 💬
1件: AR 💬 Danazol 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
224 Prostate cancer 💬
1件: AR 💬 Flutamide 💬 Flutamide 1件: 81 💬
225 Prostate cancer 💬
1件: AR 💬 Nandrolone 💬 Nandrolone 2件: 60, 85 💬
226 Prostate cancer 💬
1件: AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate 2件: 60, 85 💬
227 Prostate cancer 💬
1件: AR 💬 Oxandrolone 💬 Oxandrolone 2件: 211, 285 💬
228 Prostate cancer 💬
1件: AR 💬 Prasterone 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
229 Prostate cancer 💬
1件: AR 💬 Stanozolol 💬 Stanozolol 1件: 60 💬
230 Prostate cancer 💬
1件: AR 💬 Testosterone 💬 Testosterone 8件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
231 Prostate cancer 💬
1件: AR 💬 Testosterone decanoate 💬 Testosterone decanoate 1件: 113 💬
232 Prostate cancer 💬
1件: AR 💬 Testosterone enanthate 💬 Testosterone enanthate 1件: 113 💬
233 Prostate cancer 💬
1件: AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate 1件: 113 💬
234 Prostate cancer 💬
1件: AR 💬 Testosterone propionate 💬 Testosterone propionate 1件: 113 💬
235 Prostate cancer 💬
1件: AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate 2件: 13, 60 💬
236 Rheumatoid arthritis 💬
5件: CCL2, IL1A, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
237 Rheumatoid arthritis 💬
2件: CD80, CD86 💬 Abatacept 💬 Abatacept 26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
238 Rheumatoid arthritis 💬
2件: CD80, CD86 💬 Belatacept 💬 Belatacept 1件: 46 💬
239 Rheumatoid arthritis 💬
1件: CSF2 💬 Otilimab 💬 Otilimab 1件: 46 💬
240 Rheumatoid arthritis 💬
1件: CTLA4 💬 Ipilimumab 💬 Ipilimumab 1件: 159 💬
241 Rheumatoid arthritis 💬
1件: CTLA4 💬 Tremelimumab 💬 Tremelimumab 1件: 96 💬
242 Rheumatoid arthritis 💬
1件: FLT1 💬 Axitinib 💬 Axitinib 1件: 34 💬
243 Rheumatoid arthritis 💬
1件: FLT1 💬 Cediranib 💬 Cediranib 1件: 34 💬
244 Rheumatoid arthritis 💬
1件: FLT1 💬 Nintedanib 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
245 Rheumatoid arthritis 💬
1件: FLT1 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
246 Rheumatoid arthritis 💬
1件: IFNG 💬 Emapalumab 💬 Emapalumab 3件: 49, 65, 107 💬
247 Rheumatoid arthritis 💬
1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
248 Rheumatoid arthritis 💬
1件: IL17A 💬 Bimekizumab 💬 Bimekizumab 3件: 46, 97, 271 💬
249 Rheumatoid arthritis 💬
1件: IL17A 💬 Ixekizumab 💬 Ixekizumab 8件: 36, 37, 46, 107, 160, 162, 269, 271 💬
250 Rheumatoid arthritis 💬
1件: IL17A 💬 Secukinumab 💬 Secukinumab 8件: 13, 37, 41, 46, 107, 160, 269, 271 💬
251 Rheumatoid arthritis 💬
2件: IL17A, TNFSF13B 💬 Tibulizumab 💬 Tibulizumab 1件: 53 💬
252 Rheumatoid arthritis 💬
1件: IL1A 💬 Bermekimab 💬 Bermekimab 1件: 51 💬
253 Rheumatoid arthritis 💬
2件: IL1A, IL1B 💬 Rilonacept 💬 Rilonacept 4件: 51, 106, 107, 266 💬
254 Rheumatoid arthritis 💬
1件: IL1B 💬 Canakinumab 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
255 Rheumatoid arthritis 💬
1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
256 Rheumatoid arthritis 💬
1件: IL23A 💬 Brazikumab 💬 Brazikumab 2件: 96, 97 💬
257 Rheumatoid arthritis 💬
1件: IL23A 💬 Guselkumab 💬 Guselkumab 5件: 37, 41, 51, 96, 97 💬
258 Rheumatoid arthritis 💬
1件: IL23A 💬 Mirikizumab 💬 Mirikizumab 3件: 37, 96, 97 💬
259 Rheumatoid arthritis 💬
1件: IL23A 💬 Risankizumab 💬 Risankizumab 4件: 37, 96, 97, 271 💬
260 Rheumatoid arthritis 💬
1件: IL23A 💬 Tildrakizumab 💬 Tildrakizumab 2件: 162, 271 💬
261 Rheumatoid arthritis 💬
1件: IL23A 💬 Ustekinumab 💬 Ustekinumab 16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
262 Rheumatoid arthritis 💬
1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬
263 Rheumatoid arthritis 💬
1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬
264 Rheumatoid arthritis 💬
1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬
265 Rheumatoid arthritis 💬
2件: IL6, TNF 💬 Pomalidomide 💬 Pomalidomide 5件: 28, 51, 85, 227, 331 💬
266 Rheumatoid arthritis 💬
1件: ITGAL 💬 Efalizumab 💬 Efalizumab 9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
267 Rheumatoid arthritis 💬
1件: LTB 💬 Baminercept 💬 Baminercept 4件: 13, 46, 53, 97 💬
268 Rheumatoid arthritis 💬
3件: TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab 3件: 51, 85, 222 💬
269 Rheumatoid arthritis 💬
1件: TNF 💬 Adalimumab 💬 Adalimumab 17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
270 Rheumatoid arthritis 💬
1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
271 Rheumatoid arthritis 💬
1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
272 Rheumatoid arthritis 💬
1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
273 Rheumatoid arthritis 💬
1件: TNF 💬 Infliximab 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
274 Rheumatoid arthritis 💬
1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
275 Rheumatoid arthritis 💬
1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
276 Rheumatoid arthritis 💬
1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
277 Rheumatoid arthritis 💬
1件: TNF 💬 Thalidomide 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
278 Rheumatoid arthritis 💬
1件: TNFSF11 💬 Denosumab 💬 Denosumab 8件: 46, 50, 70, 93, 95, 96, 274, 299 💬
279 Rheumatoid arthritis 💬
2件: TNFSF13, TNFSF13B 💬 Atacicept 💬 Atacicept 4件: 13, 46, 49, 66 💬
280 Rheumatoid arthritis 💬
1件: TNFSF13B 💬 Belimumab 💬 Belimumab 13件: 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
281 Rheumatoid arthritis 💬
1件: TNFSF13B 💬 Tabalumab 💬 Tabalumab 2件: 46, 49 💬
282 Rheumatoid arthritis 💬
1件: VEGFA 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬
283 Rheumatoid arthritis 💬
1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 6件: 13, 34, 85, 87, 227, 280 💬
284 Rheumatoid arthritis 💬
1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬