Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Chemokine signaling pathway 💬
2件: JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
2 Chemokine signaling pathway 💬
2件: JAK2, JAK3 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
3 Epstein-Barr virus infection 💬
2件: JAK1, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
4 Epstein-Barr virus infection 💬
3件: JAK1, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
5 Hepatitis B 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
6 Hepatitis B 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
7 Human T-cell leukemia virus 1 infection 💬
2件: JAK1, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
8 Human T-cell leukemia virus 1 infection 💬
2件: JAK1, JAK3 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
9 JAK-STAT signaling pathway 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
10 JAK-STAT signaling pathway 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
11 Measles 💬
2件: JAK1, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
12 Measles 💬
3件: JAK1, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
13 Necroptosis 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
14 Necroptosis 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
15 Non-small cell lung cancer 💬
1件: JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
16 Non-small cell lung cancer 💬
1件: JAK3 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
17 Pathways in cancer 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
18 Pathways in cancer 💬
3件: JAK1, JAK2, JAK3 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
19 PI3K-Akt signaling pathway 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
20 PI3K-Akt signaling pathway 💬
3件: JAK1, JAK2, JAK3 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
21 Primary immunodeficiency 💬
1件: JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
22 Primary immunodeficiency 💬
1件: JAK3 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
23 Signaling pathways regulating pluripotency of stem cells 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
24 Signaling pathways regulating pluripotency of stem cells 💬
3件: JAK1, JAK2, JAK3 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
25 Th1 and Th2 cell differentiation 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
26 Th1 and Th2 cell differentiation 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
27 Th17 cell differentiation 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
28 Th17 cell differentiation 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
29 Viral carcinogenesis 💬
2件: JAK1, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
30 Viral carcinogenesis 💬
2件: JAK1, JAK3 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬