Drug Description in Trials / DrugBank / KEGG DRUG

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DrugBank

Drug (Description in trials)

KEGG DRUG

KEGG GENES

KEGG PATHWAY

Disease ID

1

[1] Ampreloxetine

[1] Ampreloxetine 💬

[2] SLC6A2,
SLC6A4 💬

[2] Serotonergic synapse, Synaptic vesicle cycle 💬

[2] 6, 17 💬

2

[2] Angiotensin; Angiotensin II

[2] Angiotensin II ,
Angiotensin II 💬

[2] AGTR1,
AGTR2 💬

[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, A ...

[7] 17, 19, 46, 66, 86, 222, 224 💬

3

[2] Atomoxetine; Strattera

[1] Atomoxetine 💬

[1] SLC6A2 💬

[1] Synaptic vesicle cycle 💬

[4] 6, 8, 13, 17 💬

4

Botulinum toxin type A

[8] BOTOX; Botulinum toxin A; BOTULINUM TOXIN TYPE A; BTX-A; Dysport; IncobotulinumtoxinA; Onabotuli ...

[1] Botulinum toxin type A 💬

[1] SNAP25 💬

[2] Insulin secretion, Synaptic vesicle cycle 💬

[14] 2, 5, 6, 7, 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
5	Progressive supranuclear palsy
6	Parkinson disease
7	Corticobasal degeneration
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
17	Multiple system atrophy
36	Epidermolysis bullosa
47	Buerger disease
51	Scleroderma
70	Spinal stenosis
113	Muscular dystrophy
149	Hemiconvulsion hemiplegia epilepsy syndrome
226	Interstitial cystitis with Hunners ulcer

5

[0]

-

-

-

[1] 17 💬

6

[1] Captopril 💬

[1] ACE 💬

[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyop ...

[8] 6, 17, 46, 86, 96, 97, 107, 271 💬

Disease ID	Name
6	Parkinson disease
17	Multiple system atrophy
46	Malignant rheumatoid arthritis
86	Pulmonary arterial hypertension
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
271	Ankylosing spondylitis

7

[8] CARBIDOPA; Carbidopa-Levodopa; DUODOPA; Lodosyn; PARCOPA; SINEMET; SINEMET CR; Stalevo

[1] Carbidopa 💬

[1] DDC 💬

[9] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Metabolic pathways, ...

[7] 6, 13, 17, 90, 140, 164, 201 💬

8

-

-

-

[12] 2, 13, 17, 18, 19, 46, 53, 75, 96, 127, 235, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
13	Multiple sclerosis/Neuromyelitis optica
17	Multiple system atrophy
18	Spinocerebellar degeneration
19	Lysosomal storage disease
46	Malignant rheumatoid arthritis
53	Sjogren syndrome
75	Cushing disease
96	Crohn disease
127	Frontotemporal lobar degeneration
235	Hypoparathyroidism
299	Cystic fibrosis

9

[1] Domperidone

[2] Domperidone ,
Domperidone maleate 💬

[1] DRD2 💬

[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor i ...

[5] 6, 13, 17, 51, 230 💬

10

[4] DOPS; Droxidopa; L-DOPS; Northera

[1] Droxidopa 💬

[9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬

Name	Full Name
ADRA1A	adrenoceptor alpha 1A
ADRA1B	adrenoceptor alpha 1B
ADRA1D	adrenoceptor alpha 1D
ADRA2A	adrenoceptor alpha 2A
ADRA2B	adrenoceptor alpha 2B
ADRA2C	adrenoceptor alpha 2C
ADRB1	adrenoceptor beta 1
ADRB2	adrenoceptor beta 2
ADRB3	adrenoceptor beta 3

[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chem ...

[5] 5, 6, 17, 169, 170 💬

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