Target Gene/Pathway Pathway / Gene

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No.

KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[10] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction

Topiramate 💬

[6] 6, 97, 140, 144, 156, 193 💬

2

[10] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction

[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
3	Spinal muscular atrophy
5	Progressive supranuclear palsy
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
17	Multiple system atrophy
18	Spinocerebellar degeneration
203	22q11.2 deletion syndrome
206	Fragile X syndrome

3

[10] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction

Talampanel 💬

[2] 2, 6 💬

4

[10] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction

Perampanel 💬

[3] 2, 6, 144 💬