Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Metformin [5] Metformin; Metformin HCl; Metformin hydrochloride; Metformina; Metformine[1] Metformin 💬[2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
2 Pioglitazone
(Pioglitazole and metformin hydrochloride)		[1] Pioglitazone[1] Pioglitazone 💬[1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
3 Repaglinide
(Repaglinide and Metformin Hydrochloride)		[1] Repaglinide[1] Repaglinide 💬[2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[4] 6, 21, 46, 299 💬
4 Rosiglitazone
(PMS-rosiglitazone-metformin)		[2] Rosiglitazone; Rosiglitazone maleate[1] Rosiglitazone 💬[1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[5] 46, 75, 97, 222, 265 💬
5 Sitagliptin
(Apo-sitagliptin/metformin XR)		[1] Sitagliptin[1] Sitagliptin 💬[1] DPP4 💬[1] Protein digestion and absorption 💬[4] 6, 75, 233, 299 💬