171. ウィルソン病 Disease details / Clinical trials / Drug dev / DR info
臨床試験数 : 79 / 薬物数 : 77 - (DrugBank : 17) / 標的遺伝子数 : 6 - 標的パスウェイ数 : 30
薬物ごとの開発者（Primary Sponsor）、臨床試験情報（抜粋）です。
64CuCl2
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
64Cu]Cl2
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
ALXN1840
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
Alexion Pharmaceuticals
2021 Phase 3 NCT05047523 Australia;Japan;Korea, Republic of;Poland;Spain;
2020 Phase 2 NCT04573309 New Zealand;United Kingdom;United States;
2020 Phase 1 NCT04526210 United States;
2020 Phase 1 NCT04526197 United States;
2018 Phase 3 NCT03403205 Australia;Austria;Belgium;Canada;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Taiwan;Turkey;United Kingdom;United States;
2014 Phase 2 NCT02273596 Austria;Germany;Poland;United Kingdom;United States;
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Alexion Pharmaceuticals, Inc
2021 Phase 2 EUCTR2019-003711-60-DE Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-GB Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-FR Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-DK Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-AT Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-SE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-DK Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2021 Phase 3 EUCTR2021-001015-82-ES Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
2021 Phase 3 EUCTR2021-001015-82-DE Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2020-001104-41-GB United Kingdom;
- Phase 3 EUCTR2021-001015-82-PL Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Adeno-associated viral vector serotype 3B encoding shortened human ATP7B
Vivet Therapeutics SAS
2021 Phase 1;Phase 2 EUCTR2020-000963-22-DK Denmark;Germany;United Kingdom;United States;
2021 Phase 1;Phase 2 EUCTR2020-000963-22-DE Denmark;Germany;United Kingdom;United States;
Adeno-associated viral vector serotype 9 encoding human ATP7B
Ultragenyx Pharmaceutical Inc.
2022 Phase 1;Phase 2;Phase 3 EUCTR2020-005266-34-ES Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
Artamin
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
BIS-CHOLINE TETRATHIOMOLYBDATE
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Alexion Pharmaceuticals, Inc
2021 Phase 2 EUCTR2019-003711-60-DE Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-GB Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-FR Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-DK Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-AT Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-SE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-DK Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2020 Phase 2 EUCTR2020-001104-41-GB United Kingdom;
- Phase 3 EUCTR2017-004135-36-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Wilson Therapeutics AB
2018 Phase 3 EUCTR2017-004135-36-HU Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-GB Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-FR Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-ES Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
BIS-CHOLINE TETRATHIOMOLYBDATE, bis[(2-Hydroxyethyl)trimethylammonium] tetrathiomolybdate
Alexion Pharmaceuticals, Inc.
2021 Phase 3 EUCTR2021-001015-82-ES Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
2021 Phase 3 EUCTR2021-001015-82-DE Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2021-001015-82-PL Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
Bis-Choline Tetrathiomolybdate
Alexion Pharmaceuticals
2020 Phase 2 NCT04422431 Australia;Austria;Belgium;Canada;Denmark;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Singapore;Spain;United Kingdom;United States;
Bis-choline TETRATHIOMOLYBDATE
Alexion Pharmaceuticals, INC.
2014 Phase 2 EUCTR2014-001703-41-DE Austria;Germany;Poland;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2014 Phase 2 EUCTR2014-001703-41-AT Austria;Germany;Poland;United Kingdom;United States;
Wilson Therapeutics AB
2015 Phase 2 EUCTR2014-001703-41-GB Austria;Germany;Poland;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001703-41-PL Austria;Germany;Poland;United Kingdom;United States;
Bupropion Hydrochloride
Alexion Pharmaceuticals
2020 Phase 1 NCT04526210 United States;
COPPER (64CU) CHLORIDE
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
Celecoxib
Alexion Pharmaceuticals
2020 Phase 1 NCT04526197 United States;
Copper
Anhui Provincial Hospital
2017 - ChiCTR-DDD-17010552 China;
Shanghai Tongren Hospital
2019 Phase 0 ChiCTR1900023410 China;
Cufence (trientine dihydrochloride)
Univar Solutions, B.V.
2021 Phase 4 EUCTR2020-004604-33-PL Denmark;Germany;Poland;
2021 Phase 4 EUCTR2020-004604-33-DK Denmark;Germany;Poland;
2021 Phase 4 EUCTR2020-004604-33-DE Denmark;France;Germany;Poland;
- Phase 4 EUCTR2020-004604-33-FR Denmark;France;Germany;Poland;
Cuprior
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Cuprior 150 mg film-coated tablets
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DK Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Cuprior 150mg film-coated tablets
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
D-penicillamine
GMP ORPHAN SA
2017 Phase 3 EUCTR2016-003876-29-IT Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DK Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
DMPS
Second Affiliated Hospital, School of Medicine, Zhejiang University
2019 Early Phase 1 NCT03957720 China;
DMSA
Second Affiliated Hospital, School of Medicine, Zhejiang University
2019 Early Phase 1 NCT03957720 China;
Fibroscan
University of Aarhus
2016 - NCT02702765 Denmark;
Functional hepatic nitrogen clearance
University of Aarhus
2016 - NCT02702765 Denmark;
Galactose
University of Aarhus
2016 - NCT02702765 Denmark;
Gold
Anhui Provincial Hospital
2017 - ChiCTR-DDD-17010552 China;
Shanghai Tongren Hospital
2019 Phase 0 ChiCTR1900023410 China;
Liver biopsy
University of Aarhus
2016 - NCT02702765 Denmark;
Low copper diet
Second Affiliated Hospital, School of Medicine, Zhejiang University
2004 - NCT04965545 China;
Metalcaptase
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Metalcaptase® 150 mg gastro-resistant tablet
Orphalan
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Metalcaptase® 300 mg gastro-resistant tablet
Orphalan
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
NPC-02
Nobelpharma
2005 Phase 3 NCT00212355 -
None
Alexion Pharmaceuticals, INC.
2014 Phase 2 EUCTR2014-001703-41-DE Austria;Germany;Poland;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2014 Phase 2 EUCTR2014-001703-41-AT Austria;Germany;Poland;United Kingdom;United States;
Wilson Therapeutics AB
2015 Phase 2 EUCTR2014-001703-41-GB Austria;Germany;Poland;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001703-41-PL Austria;Germany;Poland;United Kingdom;United States;
Once a day Trientine
Yale University
2010 - NCT01472874 United States;
Oral corticosteroids
Ultragenyx Pharmaceutical Inc
2021 Phase 1/Phase 2 NCT04884815 United States;
PEMINE - 150 MG CAPSULE RIGIDE 50 CAPSULE
GMP ORPHAN SA
2017 Phase 3 EUCTR2016-003876-29-IT Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
Penicillamine
GMP-Orphan SAS
2018 Phase 3 NCT03539952 Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Orphalan
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Second Affiliated Hospital, School of Medicine, Zhejiang University
2019 Early Phase 1 NCT03957720 China;
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-AT Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
SoC Therapy
Alexion Pharmaceuticals
2018 Phase 3 NCT03403205 Australia;Austria;Belgium;Canada;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Taiwan;Turkey;United Kingdom;United States;
TETA 4HCL
GMP-Orphan SAS
2018 Phase 3 NCT03539952 Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
TETA 4HCl
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DK Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-AT Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
TETA.4HCI
GMP ORPHAN SA
2017 Phase 3 EUCTR2016-003876-29-IT Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
TETA.4HCl
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
TRIENTINE DIHYDROCHLORIDE
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Alexion Pharmaceuticals, Inc
2020 Phase 3 EUCTR2017-004135-36-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-SE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-DK Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Wilson Therapeutics AB
2018 Phase 3 EUCTR2017-004135-36-HU Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-GB Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-FR Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-ES Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
Tetrathiomolybdate
National Center for Research Resources (NCRR)
1994 Phase 3 NCT00004339 United States;
Tiomolibdic acid
Alexion Pharmaceuticals, Inc.
2021 Phase 3 EUCTR2021-001015-82-ES Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
2021 Phase 3 EUCTR2021-001015-82-DE Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2021-001015-82-PL Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
Trientine
Excelsior
2018 - NCT03299829 Taiwan;
National Center for Research Resources (NCRR)
1994 Phase 3 NCT00004339 United States;
Trientine dihydrochloride
Univar BV
2016 Phase 4 NCT02426905 Germany;Greece;Italy;United Kingdom;
2013 Phase 1 NCT01874028 Germany;
Trientine dihydrochloride 300mg capsules
UNIVAR LTD
2016 Phase 2 EUCTR2013-003564-31-IT France;Germany;Greece;Italy;Spain;United Kingdom;
Univar B.V.
2014 Phase 4 EUCTR2013-003564-31-DE Germany;Italy;
Trientine tetrahydrochloride
GMP ORPHAN SA
2017 Phase 3 EUCTR2016-003876-29-IT Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DK Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-AT Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
Triethylenetetramine dihydrochloride
Univar Solutions, B.V.
2021 Phase 4 EUCTR2020-004604-33-PL Denmark;Germany;Poland;
2021 Phase 4 EUCTR2020-004604-33-DK Denmark;Germany;Poland;
2021 Phase 4 EUCTR2020-004604-33-DE Denmark;France;Germany;Poland;
- Phase 4 EUCTR2020-004604-33-FR Denmark;France;Germany;Poland;
UX701
Ultragenyx Pharmaceutical Inc
2021 Phase 1/Phase 2 NCT04884815 United States;
UX701 (1.0 × 10^13 genome copies/kg)
Ultragenyx Pharmaceutical Inc.
2022 Phase 1;Phase 2;Phase 3 EUCTR2020-005266-34-ES Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
UX701 (2.0 × 10^13 genome copies/kg)
Ultragenyx Pharmaceutical Inc.
2022 Phase 1;Phase 2;Phase 3 EUCTR2020-005266-34-ES Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
UX701 (5.0 × 10^12 genome copies/kg)
Ultragenyx Pharmaceutical Inc.
2022 Phase 1;Phase 2;Phase 3 EUCTR2020-005266-34-ES Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
Ultrasound
University of Aarhus
2016 - NCT02702765 Denmark;
VTX-801
Vivet Therapeutics SAS
2021 Phase 1;Phase 2 EUCTR2020-000963-22-DK Denmark;Germany;United Kingdom;United States;
2021 Phase 1;Phase 2 EUCTR2020-000963-22-DE Denmark;Germany;United Kingdom;United States;
WTX101
Alexion Pharmaceuticals, INC.
2014 Phase 2 EUCTR2014-001703-41-DE Austria;Germany;Poland;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2014 Phase 2 EUCTR2014-001703-41-AT Austria;Germany;Poland;United Kingdom;United States;
Wilson Therapeutics AB
2018 Phase 3 EUCTR2017-004135-36-HU Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-GB Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-FR Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-ES Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2015 Phase 2 EUCTR2014-001703-41-GB Austria;Germany;Poland;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001703-41-PL Austria;Germany;Poland;United Kingdom;United States;
Wilzin
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
ZINC ACETATE DIHYDRATE
Alexion Pharmaceuticals, Inc
2020 Phase 3 EUCTR2017-004135-36-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-SE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-DK Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
- Phase 3 EUCTR2017-004135-36-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Wilson Therapeutics AB
2018 Phase 3 EUCTR2017-004135-36-HU Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-GB Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-FR Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-ES Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
Zinc
Prof. Elon Pras
2018 - NCT03659331 -
Zinc acetate
National Center for Research Resources (NCRR)
1993 Phase 4 NCT00004338 United States;
Nobelpharma
2004 Phase 3 NCT00212368 -
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
Zinc gluconate
Second Affiliated Hospital, School of Medicine, Zhejiang University
2019 Early Phase 1 NCT03957720 China;
Zink Natur-Drogeriet
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
64Cu]Cl2
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
ALXN1840
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
Alexion Pharmaceuticals
2021 Phase 3 NCT05047523 Australia;Japan;Korea, Republic of;Poland;Spain;
2020 Phase 2 NCT04573309 New Zealand;United Kingdom;United States;
2020 Phase 1 NCT04526210 United States;
2020 Phase 1 NCT04526197 United States;
2018 Phase 3 NCT03403205 Australia;Austria;Belgium;Canada;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Taiwan;Turkey;United Kingdom;United States;
2014 Phase 2 NCT02273596 Austria;Germany;Poland;United Kingdom;United States;
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Alexion Pharmaceuticals, Inc
2021 Phase 2 EUCTR2019-003711-60-DE Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-GB Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-FR Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-DK Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-AT Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-SE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-DK Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2021 Phase 3 EUCTR2021-001015-82-ES Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
2021 Phase 3 EUCTR2021-001015-82-DE Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2020-001104-41-GB United Kingdom;
- Phase 3 EUCTR2021-001015-82-PL Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Adeno-associated viral vector serotype 3B encoding shortened human ATP7B
Vivet Therapeutics SAS
2021 Phase 1;Phase 2 EUCTR2020-000963-22-DK Denmark;Germany;United Kingdom;United States;
2021 Phase 1;Phase 2 EUCTR2020-000963-22-DE Denmark;Germany;United Kingdom;United States;
Adeno-associated viral vector serotype 9 encoding human ATP7B
Ultragenyx Pharmaceutical Inc.
2022 Phase 1;Phase 2;Phase 3 EUCTR2020-005266-34-ES Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
Artamin
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
BIS-CHOLINE TETRATHIOMOLYBDATE
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Alexion Pharmaceuticals, Inc
2021 Phase 2 EUCTR2019-003711-60-DE Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-GB Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-FR Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-DK Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2020 Phase 2 EUCTR2019-003711-60-AT Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-SE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-DK Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2020 Phase 2 EUCTR2020-001104-41-GB United Kingdom;
- Phase 3 EUCTR2017-004135-36-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Wilson Therapeutics AB
2018 Phase 3 EUCTR2017-004135-36-HU Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-GB Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-FR Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-ES Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
BIS-CHOLINE TETRATHIOMOLYBDATE, bis[(2-Hydroxyethyl)trimethylammonium] tetrathiomolybdate
Alexion Pharmaceuticals, Inc.
2021 Phase 3 EUCTR2021-001015-82-ES Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
2021 Phase 3 EUCTR2021-001015-82-DE Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2021-001015-82-PL Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
Bis-Choline Tetrathiomolybdate
Alexion Pharmaceuticals
2020 Phase 2 NCT04422431 Australia;Austria;Belgium;Canada;Denmark;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Singapore;Spain;United Kingdom;United States;
Bis-choline TETRATHIOMOLYBDATE
Alexion Pharmaceuticals, INC.
2014 Phase 2 EUCTR2014-001703-41-DE Austria;Germany;Poland;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2014 Phase 2 EUCTR2014-001703-41-AT Austria;Germany;Poland;United Kingdom;United States;
Wilson Therapeutics AB
2015 Phase 2 EUCTR2014-001703-41-GB Austria;Germany;Poland;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001703-41-PL Austria;Germany;Poland;United Kingdom;United States;
Bupropion Hydrochloride
Alexion Pharmaceuticals
2020 Phase 1 NCT04526210 United States;
COPPER (64CU) CHLORIDE
Aarhus University Hospital
2021 Phase 2 EUCTR2021-000102-25-DK Denmark;
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
Celecoxib
Alexion Pharmaceuticals
2020 Phase 1 NCT04526197 United States;
Copper
Anhui Provincial Hospital
2017 - ChiCTR-DDD-17010552 China;
Shanghai Tongren Hospital
2019 Phase 0 ChiCTR1900023410 China;
Cufence (trientine dihydrochloride)
Univar Solutions, B.V.
2021 Phase 4 EUCTR2020-004604-33-PL Denmark;Germany;Poland;
2021 Phase 4 EUCTR2020-004604-33-DK Denmark;Germany;Poland;
2021 Phase 4 EUCTR2020-004604-33-DE Denmark;France;Germany;Poland;
- Phase 4 EUCTR2020-004604-33-FR Denmark;France;Germany;Poland;
Cuprior
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Cuprior 150 mg film-coated tablets
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DK Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Cuprior 150mg film-coated tablets
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
D-penicillamine
GMP ORPHAN SA
2017 Phase 3 EUCTR2016-003876-29-IT Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DK Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
DMPS
Second Affiliated Hospital, School of Medicine, Zhejiang University
2019 Early Phase 1 NCT03957720 China;
DMSA
Second Affiliated Hospital, School of Medicine, Zhejiang University
2019 Early Phase 1 NCT03957720 China;
Fibroscan
University of Aarhus
2016 - NCT02702765 Denmark;
Functional hepatic nitrogen clearance
University of Aarhus
2016 - NCT02702765 Denmark;
Galactose
University of Aarhus
2016 - NCT02702765 Denmark;
Gold
Anhui Provincial Hospital
2017 - ChiCTR-DDD-17010552 China;
Shanghai Tongren Hospital
2019 Phase 0 ChiCTR1900023410 China;
Liver biopsy
University of Aarhus
2016 - NCT02702765 Denmark;
Low copper diet
Second Affiliated Hospital, School of Medicine, Zhejiang University
2004 - NCT04965545 China;
Metalcaptase
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Metalcaptase® 150 mg gastro-resistant tablet
Orphalan
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Metalcaptase® 300 mg gastro-resistant tablet
Orphalan
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
NPC-02
Nobelpharma
2005 Phase 3 NCT00212355 -
None
Alexion Pharmaceuticals, INC.
2014 Phase 2 EUCTR2014-001703-41-DE Austria;Germany;Poland;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2014 Phase 2 EUCTR2014-001703-41-AT Austria;Germany;Poland;United Kingdom;United States;
Wilson Therapeutics AB
2015 Phase 2 EUCTR2014-001703-41-GB Austria;Germany;Poland;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001703-41-PL Austria;Germany;Poland;United Kingdom;United States;
Once a day Trientine
Yale University
2010 - NCT01472874 United States;
Oral corticosteroids
Ultragenyx Pharmaceutical Inc
2021 Phase 1/Phase 2 NCT04884815 United States;
PEMINE - 150 MG CAPSULE RIGIDE 50 CAPSULE
GMP ORPHAN SA
2017 Phase 3 EUCTR2016-003876-29-IT Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
Penicillamine
GMP-Orphan SAS
2018 Phase 3 NCT03539952 Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Orphalan
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Second Affiliated Hospital, School of Medicine, Zhejiang University
2019 Early Phase 1 NCT03957720 China;
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-AT Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
SoC Therapy
Alexion Pharmaceuticals
2018 Phase 3 NCT03403205 Australia;Austria;Belgium;Canada;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Taiwan;Turkey;United Kingdom;United States;
TETA 4HCL
GMP-Orphan SAS
2018 Phase 3 NCT03539952 Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
TETA 4HCl
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DK Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-AT Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
TETA.4HCI
GMP ORPHAN SA
2017 Phase 3 EUCTR2016-003876-29-IT Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
TETA.4HCl
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
TRIENTINE DIHYDROCHLORIDE
Alexion Pharmaceuticals Inc.
2021 Phase 2 EUCTR2020-005832-31-DK Denmark;
Alexion Pharmaceuticals, Inc
2020 Phase 3 EUCTR2017-004135-36-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-SE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-DK Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Wilson Therapeutics AB
2018 Phase 3 EUCTR2017-004135-36-HU Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-GB Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-FR Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-ES Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
Tetrathiomolybdate
National Center for Research Resources (NCRR)
1994 Phase 3 NCT00004339 United States;
Tiomolibdic acid
Alexion Pharmaceuticals, Inc.
2021 Phase 3 EUCTR2021-001015-82-ES Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
2021 Phase 3 EUCTR2021-001015-82-DE Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2021-001015-82-PL Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
Trientine
Excelsior
2018 - NCT03299829 Taiwan;
National Center for Research Resources (NCRR)
1994 Phase 3 NCT00004339 United States;
Trientine dihydrochloride
Univar BV
2016 Phase 4 NCT02426905 Germany;Greece;Italy;United Kingdom;
2013 Phase 1 NCT01874028 Germany;
Trientine dihydrochloride 300mg capsules
UNIVAR LTD
2016 Phase 2 EUCTR2013-003564-31-IT France;Germany;Greece;Italy;Spain;United Kingdom;
Univar B.V.
2014 Phase 4 EUCTR2013-003564-31-DE Germany;Italy;
Trientine tetrahydrochloride
GMP ORPHAN SA
2017 Phase 3 EUCTR2016-003876-29-IT Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
Orphalan
2019 Phase 3 EUCTR2016-003876-29-BE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DK Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-DE Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
gmp-orphan SA
2017 Phase 3 EUCTR2016-003876-29-GB Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
2017 Phase 3 EUCTR2016-003876-29-AT Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
Triethylenetetramine dihydrochloride
Univar Solutions, B.V.
2021 Phase 4 EUCTR2020-004604-33-PL Denmark;Germany;Poland;
2021 Phase 4 EUCTR2020-004604-33-DK Denmark;Germany;Poland;
2021 Phase 4 EUCTR2020-004604-33-DE Denmark;France;Germany;Poland;
- Phase 4 EUCTR2020-004604-33-FR Denmark;France;Germany;Poland;
UX701
Ultragenyx Pharmaceutical Inc
2021 Phase 1/Phase 2 NCT04884815 United States;
UX701 (1.0 × 10^13 genome copies/kg)
Ultragenyx Pharmaceutical Inc.
2022 Phase 1;Phase 2;Phase 3 EUCTR2020-005266-34-ES Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
UX701 (2.0 × 10^13 genome copies/kg)
Ultragenyx Pharmaceutical Inc.
2022 Phase 1;Phase 2;Phase 3 EUCTR2020-005266-34-ES Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
UX701 (5.0 × 10^12 genome copies/kg)
Ultragenyx Pharmaceutical Inc.
2022 Phase 1;Phase 2;Phase 3 EUCTR2020-005266-34-ES Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
Ultrasound
University of Aarhus
2016 - NCT02702765 Denmark;
VTX-801
Vivet Therapeutics SAS
2021 Phase 1;Phase 2 EUCTR2020-000963-22-DK Denmark;Germany;United Kingdom;United States;
2021 Phase 1;Phase 2 EUCTR2020-000963-22-DE Denmark;Germany;United Kingdom;United States;
WTX101
Alexion Pharmaceuticals, INC.
2014 Phase 2 EUCTR2014-001703-41-DE Austria;Germany;Poland;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
2014 Phase 2 EUCTR2014-001703-41-AT Austria;Germany;Poland;United Kingdom;United States;
Wilson Therapeutics AB
2018 Phase 3 EUCTR2017-004135-36-HU Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-GB Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-FR Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-ES Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2015 Phase 2 EUCTR2014-001703-41-GB Austria;Germany;Poland;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001703-41-PL Austria;Germany;Poland;United Kingdom;United States;
Wilzin
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
ZINC ACETATE DIHYDRATE
Alexion Pharmaceuticals, Inc
2020 Phase 3 EUCTR2017-004135-36-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2017-004135-36-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-SE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2019 Phase 3 EUCTR2017-004135-36-DK Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2017-004135-36-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Alexion Pharmaceuticals, Inc.
- Phase 3 EUCTR2017-004135-36-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Wilson Therapeutics AB
2018 Phase 3 EUCTR2017-004135-36-HU Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-GB Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-FR Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-004135-36-ES Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
Zinc
Prof. Elon Pras
2018 - NCT03659331 -
Zinc acetate
National Center for Research Resources (NCRR)
1993 Phase 4 NCT00004338 United States;
Nobelpharma
2004 Phase 3 NCT00212368 -
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;
Zinc gluconate
Second Affiliated Hospital, School of Medicine, Zhejiang University
2019 Early Phase 1 NCT03957720 China;
Zink Natur-Drogeriet
The Department of Hepatology and Gastroenterology, Aarhus University Hospital
2019 Phase 4 EUCTR2019-000905-57-DK Denmark;