127. Frontotemporal lobar degeneration Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 90 / Drugs : 87 - (DrugBank : 30) / Drug target genes : 39 - Drug target pathways : 88
Drugs and their primary sponsors and trial info
(R)-[N-metil-11C1-PK11195(PK)
OSPEDALE S. RAFFAELE DI MILANO
2013 - EUCTR2012-004328-40-IT Italy;
18-F]DPA-714
Erasmus Medical Center
2020 Phase 2 EUCTR2020-002672-12-NL Netherlands;
18F-AV-1451
Columbia University
2016 Phase 2 NCT02676843 United States;
Skåne University Hospital, Region Skåne
2014 - EUCTR2014-000422-38-SE Sweden;
VU University Medical Center
2016 Phase 2 EUCTR2015-005604-29-NL Netherlands;
18F-AV-45
Avid Radiopharmaceuticals, Inc
2009 Phase 2 EUCTR2008-003597-18-GB United Kingdom;
18F-FDG
Avid Radiopharmaceuticals
2009 Phase 2 NCT01890343 United Kingdom;
18F-RO6958948
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden;
18F]DPA-714
Erasmus Medical Center
2020 Phase 2 EUCTR2020-002672-12-NL Netherlands;
AL001
Alector Inc.
2021 Phase 3 EUCTR2019-004066-18-FR Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-SE Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-PT Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-NL Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-IT Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-GB Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-ES Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-DE Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-BE Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2019 Phase 2 NCT03987295 Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2019 Phase 2 EUCTR2019-000138-20-NL Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2019 Phase 2 EUCTR2019-000138-20-IT Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2019 Phase 2 EUCTR2019-000138-20-GB Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2019 Phase 2 EUCTR2019-000138-20-DE Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2018 Phase 1 NCT03636204 Canada;Netherlands;United Kingdom;United States;
AV1451 Tau
Mayo Clinic
2020 - NCT04680130 United States;
Amantadine
Johns Hopkins University
2005 Phase 4 NCT00127114 United States;
Amyvid
IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
2014 - EUCTR2014-001315-40-IT Italy;
BIIB092
University of California, San Francisco
2018 Phase 1 NCT03658135 United States;
Blood sample
University Hospital, Lille
2021 - NCT05288842 France;
Brain PET scan
Avid Radiopharmaceuticals
2017 Phase 1 NCT03040713 United States;
C-11 PiB
Mayo Clinic
2020 - NCT04680130 United States;
2010 Phase 1 NCT01623284 United States;
Citalopram
Sunnybrook Health Sciences Centre
2006 Phase 4 NCT00376051 Canada;
DNL593
Denali Therapeutics Inc.
2022 Phase 1/Phase 2 NCT05262023 United Kingdom;
Davunetide (AL-108, NAP)
University of California, San Francisco
2010 Phase 1 NCT01056965 United States;
Donepezil
National Hospital Organization Kikuchi Hospital
2008 - JPRN-UMIN000003239 Japan;
EVP-0334
FORUM Pharmaceuticals Inc.
2015 Phase 2;Phase 3 EUCTR2014-001489-85-GB Belgium;France;Italy;Netherlands;United Kingdom;United States;
2015 Phase 2 EUCTR2014-001489-85-BE Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-NL Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-IT Belgium;France;Italy;Netherlands;United Kingdom;United States;
F 18 T807
Tammie L. S. Benzinger, MD, PhD
2017 Phase 2 NCT02707978 United States;
F-18
Chang Gung Memorial Hospital
2018 Early Phase 1 NCT03625128 Taiwan;
F-18 FDG
Mayo Clinic
2010 Phase 1 NCT01623284 United States;
2008 Phase 4 NCT00950430 United States;
FRM-0334
FORUM Pharmaceuticals Inc
2014 Phase 2 NCT02149160 Belgium;France;Italy;Netherlands;United Kingdom;United States;
FORUM Pharmaceuticals Inc.
2015 Phase 2;Phase 3 EUCTR2014-001489-85-GB Belgium;France;Italy;Netherlands;United Kingdom;United States;
2015 Phase 2 EUCTR2014-001489-85-BE Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-NL Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-IT Belgium;France;Italy;Netherlands;United Kingdom;United States;
Ferulic acid
Shimane University Hospital
2010 - JPRN-UMIN000003683 Japan;
Florbetapir (18F)
IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
2014 - EUCTR2014-001315-40-IT Italy;
Florbetapir 18F
Avid Radiopharmaceuticals
2009 Phase 2 NCT01890343 United Kingdom;
Florbetapir 18F Injection
Avid Radiopharmaceuticals, Inc
2009 Phase 2 EUCTR2008-003597-18-GB United Kingdom;
Flortaucipir F18
Avid Radiopharmaceuticals
2017 Phase 1 NCT03040713 United States;
Flutemetamol F18
Skane University Hospital
2017 - NCT03174938 Sweden;
Galantamine hydrobromide
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2003 Phase 2 NCT00416169 -
Histone Deacetylase Inhibitor
FORUM Pharmaceuticals Inc.
2015 Phase 2;Phase 3 EUCTR2014-001489-85-GB Belgium;France;Italy;Netherlands;United Kingdom;United States;
2015 Phase 2 EUCTR2014-001489-85-BE Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-NL Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-IT Belgium;France;Italy;Netherlands;United Kingdom;United States;
Intranasal oxytocin
Lawson Health Research Institute
2013 Phase 2 NCT01937013 Canada;
2009 - NCT01002300 Canada;
LMTM
TauRx Therapeutics Ltd
2014 Phase 3 NCT02245568 Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
LMTM/TRx0237
TauRx Therapeutics Ltd
2016 Phase 3 EUCTR2014-002013-37-NL Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-HR Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-FI Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-ES Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-BE Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2014-002013-37-GB Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-PL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-IT Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-HR Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-FI Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-ES Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-NL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-GB Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2012 Phase 3 EUCTR2011-005529-34-DE Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
Latozinemab
Alector Inc.
2019 Phase 2 EUCTR2019-000138-20-DE Canada;Germany;Italy;Netherlands;United Kingdom;United States;
Leucine
Washington University School of Medicine
2017 - NCT03545126 United States;
Leuco-methylthioninium bis(hydromethanesulfonate)
TauRx Therapeutics Ltd
2016 Phase 3 EUCTR2014-002013-37-NL Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-HR Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-FI Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-ES Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-BE Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2014-002013-37-GB Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-PL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-IT Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-HR Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-FI Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-ES Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-NL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-GB Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2012 Phase 3 EUCTR2011-005529-34-DE Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
Lumbar puncture
University Hospital, Lille
2021 - NCT05288842 France;
MTC TRx0014-001 capsules
TauRx Therapeutics PTE Ltd
2006 Phase 2 EUCTR2005-005915-13-GB United Kingdom;
Memantine
Nantes University Hospital
2005 Phase 2 NCT00200538 France;
University of California, San Francisco
2007 Phase 4 NCT00545974 United States;
2004 Phase 4 NCT00187525 -
Memantine hydrochloride
Tiffany Chow, MD
2007 Phase 3 NCT00594737 Canada;
Metformin
University of Florida
2020 Phase 2 NCT04220021 United States;
Methylprednisolone
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Methylthioninium chloride
TauRx Therapeutics PTE Ltd
2006 Phase 2 EUCTR2005-005915-13-GB United Kingdom;
N,N,N',N'-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)
TauRx Therapeutics Ltd
2016 Phase 3 EUCTR2014-002013-37-NL Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-HR Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-FI Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-ES Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-BE Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2014-002013-37-GB Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
N,N,N?,N?-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)
TauRx Therapeutics Ltd
2014 Phase 3 EUCTR2011-005529-34-ES Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
N,N,N’,N’-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)
TauRx Therapeutics Ltd
2014 Phase 3 EUCTR2011-005529-34-PL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-IT Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-HR Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-FI Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-NL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-GB Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2012 Phase 3 EUCTR2011-005529-34-DE Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
Neurohormonal mechanisms
Institut National de la Santé Et de la Recherche Médicale, France
2017 - NCT03272230 France;
Novolin-R insulin
HealthPartners Institute
2019 Phase 2 NCT04115384 United States;
Open label - AL001
Alector Inc.
2020 Phase 3 NCT04374136 Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
Oxytocin
Lawson Health Research Institute
2011 Phase 1 NCT01386333 Canada;
PBFT02
Passage Bio, Inc.
2021 Phase 1/Phase 2 NCT04747431 Brazil;Canada;Italy;Portugal;United Kingdom;United States;
PEA-LUT
I.R.C.C.S. Fondazione Santa Lucia
2019 - NCT04489017 Italy;
PR006
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Pittsburgh Compound B (C-11 PiB)
Mayo Clinic
2008 Phase 4 NCT00950430 United States;
Prednisone
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Rituximab
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Rotigotine 4Mg/24Hrs Patch
I.R.C.C.S. Fondazione Santa Lucia
2021 Phase 2 NCT04937452 Italy;
Rotigotine 6Mg/24Hrs Patch
I.R.C.C.S. Fondazione Santa Lucia
2021 Phase 2 NCT04937452 Italy;
Saline Nasal Mist
Lawson Health Research Institute
2013 Phase 2 NCT01937013 Canada;
2011 Phase 1 NCT01386333 Canada;
Sirolimus
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Synthetic stereopure antisense oligonucleotide targeting human C9orf72 hexanucleotide repeat-containing mRNA transcripts
Wave Life Sciences UK Limited
2022 Phase 1;Phase 2 EUCTR2020-005193-94-SE Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States;
2022 Phase 1;Phase 2 EUCTR2020-005193-94-BE Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States;
Syntocinon
Lawson Health Research Institute
2018 Phase 2 NCT03260920 Canada;United States;
T807
VU University Medical Center
2016 Phase 2 EUCTR2015-005604-29-NL Netherlands;
TPN-101
Transposon Therapeutics, Inc
2022 Phase 2 EUCTR2021-002251-11-ES Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States;
TPN-101, 400 mg/day
Transposon Therapeutics, Inc.
2021 Phase 2 NCT04993755 France;United States;
TRx0237
TauRx Therapeutics Ltd
2013 Phase 3 NCT01626378 Argentina;Australia;Bulgaria;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
Tau (18-F-AV-1451)
Mayo Clinic
2008 Phase 4 NCT00950430 United States;
Tolcapone
Columbia University
2011 Phase 2 NCT00604591 United States;
Verdiperstat
Peter Ljubenkov, MD
2022 Phase 1 NCT05184569 -
Vizamyl (flutemetamol(F-18))
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden;
WVE-004
Wave Life Sciences Ltd.
2021 Phase 1/Phase 2 NCT04931862 Australia;Canada;Ireland;Netherlands;United Kingdom;
Wave Life Sciences UK Limited
2022 Phase 1;Phase 2 EUCTR2020-005193-94-SE Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States;
2022 Phase 1;Phase 2 EUCTR2020-005193-94-BE Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States;
[18F]PI-2620
Asan Medical Center
2018 Early Phase 1 NCT03510572 Korea, Republic of;
OSPEDALE S. RAFFAELE DI MILANO
2013 - EUCTR2012-004328-40-IT Italy;
18-F]DPA-714
Erasmus Medical Center
2020 Phase 2 EUCTR2020-002672-12-NL Netherlands;
18F-AV-1451
Columbia University
2016 Phase 2 NCT02676843 United States;
Skåne University Hospital, Region Skåne
2014 - EUCTR2014-000422-38-SE Sweden;
VU University Medical Center
2016 Phase 2 EUCTR2015-005604-29-NL Netherlands;
18F-AV-45
Avid Radiopharmaceuticals, Inc
2009 Phase 2 EUCTR2008-003597-18-GB United Kingdom;
18F-FDG
Avid Radiopharmaceuticals
2009 Phase 2 NCT01890343 United Kingdom;
18F-RO6958948
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden;
18F]DPA-714
Erasmus Medical Center
2020 Phase 2 EUCTR2020-002672-12-NL Netherlands;
AL001
Alector Inc.
2021 Phase 3 EUCTR2019-004066-18-FR Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-SE Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-PT Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-NL Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-IT Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-GB Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-ES Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-DE Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2020 Phase 3 EUCTR2019-004066-18-BE Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
2019 Phase 2 NCT03987295 Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2019 Phase 2 EUCTR2019-000138-20-NL Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2019 Phase 2 EUCTR2019-000138-20-IT Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2019 Phase 2 EUCTR2019-000138-20-GB Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2019 Phase 2 EUCTR2019-000138-20-DE Canada;Germany;Italy;Netherlands;United Kingdom;United States;
2018 Phase 1 NCT03636204 Canada;Netherlands;United Kingdom;United States;
AV1451 Tau
Mayo Clinic
2020 - NCT04680130 United States;
Amantadine
Johns Hopkins University
2005 Phase 4 NCT00127114 United States;
Amyvid
IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
2014 - EUCTR2014-001315-40-IT Italy;
BIIB092
University of California, San Francisco
2018 Phase 1 NCT03658135 United States;
Blood sample
University Hospital, Lille
2021 - NCT05288842 France;
Brain PET scan
Avid Radiopharmaceuticals
2017 Phase 1 NCT03040713 United States;
C-11 PiB
Mayo Clinic
2020 - NCT04680130 United States;
2010 Phase 1 NCT01623284 United States;
Citalopram
Sunnybrook Health Sciences Centre
2006 Phase 4 NCT00376051 Canada;
DNL593
Denali Therapeutics Inc.
2022 Phase 1/Phase 2 NCT05262023 United Kingdom;
Davunetide (AL-108, NAP)
University of California, San Francisco
2010 Phase 1 NCT01056965 United States;
Donepezil
National Hospital Organization Kikuchi Hospital
2008 - JPRN-UMIN000003239 Japan;
EVP-0334
FORUM Pharmaceuticals Inc.
2015 Phase 2;Phase 3 EUCTR2014-001489-85-GB Belgium;France;Italy;Netherlands;United Kingdom;United States;
2015 Phase 2 EUCTR2014-001489-85-BE Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-NL Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-IT Belgium;France;Italy;Netherlands;United Kingdom;United States;
F 18 T807
Tammie L. S. Benzinger, MD, PhD
2017 Phase 2 NCT02707978 United States;
F-18
Chang Gung Memorial Hospital
2018 Early Phase 1 NCT03625128 Taiwan;
F-18 FDG
Mayo Clinic
2010 Phase 1 NCT01623284 United States;
2008 Phase 4 NCT00950430 United States;
FRM-0334
FORUM Pharmaceuticals Inc
2014 Phase 2 NCT02149160 Belgium;France;Italy;Netherlands;United Kingdom;United States;
FORUM Pharmaceuticals Inc.
2015 Phase 2;Phase 3 EUCTR2014-001489-85-GB Belgium;France;Italy;Netherlands;United Kingdom;United States;
2015 Phase 2 EUCTR2014-001489-85-BE Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-NL Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-IT Belgium;France;Italy;Netherlands;United Kingdom;United States;
Ferulic acid
Shimane University Hospital
2010 - JPRN-UMIN000003683 Japan;
Florbetapir (18F)
IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
2014 - EUCTR2014-001315-40-IT Italy;
Florbetapir 18F
Avid Radiopharmaceuticals
2009 Phase 2 NCT01890343 United Kingdom;
Florbetapir 18F Injection
Avid Radiopharmaceuticals, Inc
2009 Phase 2 EUCTR2008-003597-18-GB United Kingdom;
Flortaucipir F18
Avid Radiopharmaceuticals
2017 Phase 1 NCT03040713 United States;
Flutemetamol F18
Skane University Hospital
2017 - NCT03174938 Sweden;
Galantamine hydrobromide
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2003 Phase 2 NCT00416169 -
Histone Deacetylase Inhibitor
FORUM Pharmaceuticals Inc.
2015 Phase 2;Phase 3 EUCTR2014-001489-85-GB Belgium;France;Italy;Netherlands;United Kingdom;United States;
2015 Phase 2 EUCTR2014-001489-85-BE Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-NL Belgium;France;Italy;Netherlands;United Kingdom;United States;
2014 Phase 2 EUCTR2014-001489-85-IT Belgium;France;Italy;Netherlands;United Kingdom;United States;
Intranasal oxytocin
Lawson Health Research Institute
2013 Phase 2 NCT01937013 Canada;
2009 - NCT01002300 Canada;
LMTM
TauRx Therapeutics Ltd
2014 Phase 3 NCT02245568 Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
LMTM/TRx0237
TauRx Therapeutics Ltd
2016 Phase 3 EUCTR2014-002013-37-NL Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-HR Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-FI Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-ES Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-BE Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2014-002013-37-GB Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-PL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-IT Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-HR Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-FI Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-ES Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-NL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-GB Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2012 Phase 3 EUCTR2011-005529-34-DE Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
Latozinemab
Alector Inc.
2019 Phase 2 EUCTR2019-000138-20-DE Canada;Germany;Italy;Netherlands;United Kingdom;United States;
Leucine
Washington University School of Medicine
2017 - NCT03545126 United States;
Leuco-methylthioninium bis(hydromethanesulfonate)
TauRx Therapeutics Ltd
2016 Phase 3 EUCTR2014-002013-37-NL Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-HR Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-FI Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-ES Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-BE Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2014-002013-37-GB Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-PL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-IT Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-HR Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-FI Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-ES Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-NL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-GB Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2012 Phase 3 EUCTR2011-005529-34-DE Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
Lumbar puncture
University Hospital, Lille
2021 - NCT05288842 France;
MTC TRx0014-001 capsules
TauRx Therapeutics PTE Ltd
2006 Phase 2 EUCTR2005-005915-13-GB United Kingdom;
Memantine
Nantes University Hospital
2005 Phase 2 NCT00200538 France;
University of California, San Francisco
2007 Phase 4 NCT00545974 United States;
2004 Phase 4 NCT00187525 -
Memantine hydrochloride
Tiffany Chow, MD
2007 Phase 3 NCT00594737 Canada;
Metformin
University of Florida
2020 Phase 2 NCT04220021 United States;
Methylprednisolone
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Methylthioninium chloride
TauRx Therapeutics PTE Ltd
2006 Phase 2 EUCTR2005-005915-13-GB United Kingdom;
N,N,N',N'-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)
TauRx Therapeutics Ltd
2016 Phase 3 EUCTR2014-002013-37-NL Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-HR Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-FI Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-ES Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002013-37-BE Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
2014 Phase 3 EUCTR2014-002013-37-GB Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States;
N,N,N?,N?-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)
TauRx Therapeutics Ltd
2014 Phase 3 EUCTR2011-005529-34-ES Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
N,N,N’,N’-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)
TauRx Therapeutics Ltd
2014 Phase 3 EUCTR2011-005529-34-PL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-IT Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-HR Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2014 Phase 3 EUCTR2011-005529-34-FI Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-NL Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States;
2013 Phase 3 EUCTR2011-005529-34-GB Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
2012 Phase 3 EUCTR2011-005529-34-DE Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
Neurohormonal mechanisms
Institut National de la Santé Et de la Recherche Médicale, France
2017 - NCT03272230 France;
Novolin-R insulin
HealthPartners Institute
2019 Phase 2 NCT04115384 United States;
Open label - AL001
Alector Inc.
2020 Phase 3 NCT04374136 Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States;
Oxytocin
Lawson Health Research Institute
2011 Phase 1 NCT01386333 Canada;
PBFT02
Passage Bio, Inc.
2021 Phase 1/Phase 2 NCT04747431 Brazil;Canada;Italy;Portugal;United Kingdom;United States;
PEA-LUT
I.R.C.C.S. Fondazione Santa Lucia
2019 - NCT04489017 Italy;
PR006
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Pittsburgh Compound B (C-11 PiB)
Mayo Clinic
2008 Phase 4 NCT00950430 United States;
Prednisone
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Rituximab
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Rotigotine 4Mg/24Hrs Patch
I.R.C.C.S. Fondazione Santa Lucia
2021 Phase 2 NCT04937452 Italy;
Rotigotine 6Mg/24Hrs Patch
I.R.C.C.S. Fondazione Santa Lucia
2021 Phase 2 NCT04937452 Italy;
Saline Nasal Mist
Lawson Health Research Institute
2013 Phase 2 NCT01937013 Canada;
2011 Phase 1 NCT01386333 Canada;
Sirolimus
Prevail Therapeutics
2020 Phase 1/Phase 2 NCT04408625 Australia;Spain;United States;
Synthetic stereopure antisense oligonucleotide targeting human C9orf72 hexanucleotide repeat-containing mRNA transcripts
Wave Life Sciences UK Limited
2022 Phase 1;Phase 2 EUCTR2020-005193-94-SE Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States;
2022 Phase 1;Phase 2 EUCTR2020-005193-94-BE Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States;
Syntocinon
Lawson Health Research Institute
2018 Phase 2 NCT03260920 Canada;United States;
T807
VU University Medical Center
2016 Phase 2 EUCTR2015-005604-29-NL Netherlands;
TPN-101
Transposon Therapeutics, Inc
2022 Phase 2 EUCTR2021-002251-11-ES Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States;
TPN-101, 400 mg/day
Transposon Therapeutics, Inc.
2021 Phase 2 NCT04993755 France;United States;
TRx0237
TauRx Therapeutics Ltd
2013 Phase 3 NCT01626378 Argentina;Australia;Bulgaria;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States;
Tau (18-F-AV-1451)
Mayo Clinic
2008 Phase 4 NCT00950430 United States;
Tolcapone
Columbia University
2011 Phase 2 NCT00604591 United States;
Verdiperstat
Peter Ljubenkov, MD
2022 Phase 1 NCT05184569 -
Vizamyl (flutemetamol(F-18))
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden;
WVE-004
Wave Life Sciences Ltd.
2021 Phase 1/Phase 2 NCT04931862 Australia;Canada;Ireland;Netherlands;United Kingdom;
Wave Life Sciences UK Limited
2022 Phase 1;Phase 2 EUCTR2020-005193-94-SE Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States;
2022 Phase 1;Phase 2 EUCTR2020-005193-94-BE Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States;
[18F]PI-2620
Asan Medical Center
2018 Early Phase 1 NCT03510572 Korea, Republic of;