Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endoc ...

[3] 6, 13, 127 💬

2

[1] Neuroactive ligand-receptor interaction

[3] 6, 13, 127 💬

3

[4] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways, Dopaminergic synapse

[3] 6, 28, 127 💬

4

[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...

Amiodarone 💬

[2] 28, 127 💬

5

[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...

Amiodarone 💬

[2] 28, 127 💬

6

[7] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...

Amiodarone 💬

[2] 28, 127 💬

7

[11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive liga ...

Amiodarone 💬

[2] 28, 127 💬

8

[7] Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Al ...

Valproic acid 💬

[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
3	Spinal muscular atrophy
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
26	HTLV-1-associated myelopathy
65	Primary immunodeficiency
85	Idiopathic interstitial pneumonia
90	Retinitis pigmentosa
102	Rubinstein-Taybi syndrome
127	Frontotemporal lobar degeneration
222	Primary nephrotic syndrome
233	Wolfram syndrome
256	Muscle glycogenosis

9

[7] Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine me ...

Valproic acid 💬

[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
3	Spinal muscular atrophy
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
26	HTLV-1-associated myelopathy
65	Primary immunodeficiency
85	Idiopathic interstitial pneumonia
90	Retinitis pigmentosa
102	Rubinstein-Taybi syndrome
127	Frontotemporal lobar degeneration
222	Primary nephrotic syndrome
233	Wolfram syndrome
256	Muscle glycogenosis

10

[7] Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine me ...

Valproic acid 💬

[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
3	Spinal muscular atrophy
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
26	HTLV-1-associated myelopathy
65	Primary immunodeficiency
85	Idiopathic interstitial pneumonia
90	Retinitis pigmentosa
102	Rubinstein-Taybi syndrome
127	Frontotemporal lobar degeneration
222	Primary nephrotic syndrome
233	Wolfram syndrome
256	Muscle glycogenosis

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