Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1100 mg ELX (VX-445) / 50 mg TEZ / 75 mg IVA FDC----1件: 299
2100 mg ELX /50 mg TEZ /75 mg IVA FDC----1件: 299
3100 mg ELX/50 mg TEZ /75 mg IVA FDC----1件: 299
4100 mg ELX/50 mg TEZ/75 mg IVA fixed dose combination----1件: 299
5100 mg TEZ/150 mg IVA FDC----1件: 299
6100 mg VX-445 /50 mg TEZ/75 mg IVA FDC----1件: 299
7100 mg VX-445/50 mg TEZ /75 mg IVA FDC----1件: 299
8100-mg ELX (VX-445) / 50-mg TEZ / 75-mg IVA FDC----1件: 299
9100-mg ELX (VX-455) / 50-mg TEZ / 75-mg IVA FDC----1件: 299
10100-mg ELX / 50-mg TEZ / 75 -mg IVA FDC----1件: 299
11100-mg VX-445 / 50-mg TEZ / 75- mg IVA FDC----1件: 299
12100-mg VX-445 / 50-mg TEZ / 75-mg IVA FDC----1件: 299
13100-mg VX-445/50-mg TEZ/75-mg IVA FDC----1件: 299
14100g ELX / 50mg TEZ / 75mg IVA----1件: 299
15100mg ELX/50mg TEZ /75mg IVA----1件: 299
16100mg VX-445/50mg TEZ /75mg IVA FDC----1件: 299
17150-mg IVACAFTOR1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
18150mg IVACAFTOR1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
1950 mg ELX/25 mg TEZ/37.5 mg IVA----1件: 299
2050 mg ELX/25 mg TEZ/37.5 mg IVA fixed dose combination----1件: 299
2175-mg IVACAFTOR1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
2280mg ELX / 40mg TEZ / 60mg IVA----1件: 299
23CF patients with a G551D mutation and treated with Ivacaftor1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
24D-IVA----1件: 299
25Deuterated Ivacaftor1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
26Elexacaftor / Ivacaftor / Tezacaftor3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: D09916 (Name: Ivacaftor),
D11041 ,
D11507 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
27Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: D09916 (Name: Ivacaftor),
D11041 ,
D11507 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
28Elexacaftor-tezacaftor-ivacaftor exposure3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: D09916 (Name: Ivacaftor),
D11041 ,
D11507 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
29Elexacaftor/tezacaftor/ivacaftor3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: D09916 (Name: Ivacaftor),
D11041 ,
D11507 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
30ELX (VX-445)/TEZ (VX-661)/IVA (VX-770)----1件: 299
31ELX/TEZ/IVA----1件: 299
32IVA----1件: 299
33IVA 336----1件: 19
34IVA337----1件: 51
35IVACAFTOR1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
36Ivacaftor (proposed INN)1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
37Ivacaftor 125mg tablet1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
38Ivacaftor 150 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
39Ivacaftor 150 mg or 250 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
40Ivacaftor 25 mg/75 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
41IVACAFTOR 59,5mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
42IVACAFTOR 59.5mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
43Ivacaftor 75 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
44Ivacaftor 75 mg/150 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
45IVACAFTOR 75mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
46Ivacaftor Exposed1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
47Ivacaftor or elexacaftor/tezacaftor/ivacaftor3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: D09916 (Name: Ivacaftor),
D11041 ,
D11507 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
48Ivacaftor+lumacaftor2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
49Ivacaftor/Ataluren2件: Ataluren,
Ivacaftor		2件: D09323 ,
D09916 (Name: Ivacaftor)		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
50Ivacaftor/Kalydeco1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
51Ivacaftor/Trikafta1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
52LUM/IVA----1件: 299
53LUM/IVA fixed-dose combination----1件: 299
54Lumacaftor / ivacaftor2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
55Lumacaftor plus Ivacaftor2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
56Lumacaftor Plus Ivacaftor Combination2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
57Lumacaftor, Ivacaftor Drug Combination2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
58Lumacaftor-ivacaftor2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
59Lumacaftor-Ivacaftor treatment2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
60Lumacaftor/Ivacaftor2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
61Lumacaftor/ivacaftor 100mg/125mg tablets2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
62Lumacaftor/ivacaftor 200mg/125mg2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
63Lumacaftor/ivacaftor 200mg/125mg tablets2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
64Lumacaftor/ivacaftor 200mg/83mg tablet2件: Ivacaftor,
Lumacaftor		2件: D09916 (Name: Ivacaftor),
D10134 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
65Orkambi: contains lumacaftor and ivacaftor1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
66TEZ/IVA----1件: 299
67Tezacaftor/Ivacaftor2件: Ivacaftor,
Tezacaftor		2件: D09916 (Name: Ivacaftor),
D11041 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
68Tezacaftor/Ivacaftor + Ivacaftor2件: Ivacaftor,
Tezacaftor		2件: D09916 (Name: Ivacaftor),
D11041 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
69Tezacaftor/Ivacaftor 100mg/150mg2件: Ivacaftor,
Tezacaftor		2件: D09916 (Name: Ivacaftor),
D11041 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
70Tezacaftor/Ivacaftor/100mg/150mg2件: Ivacaftor,
Tezacaftor		2件: D09916 (Name: Ivacaftor),
D11041 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
71Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor4件: Elexacaftor,
Ivacaftor,
Lumacaftor,
Tezacaftor		4件: D09916 (Name: Ivacaftor),
D10134 ,
D11041 ,
D11507 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
72VX-121/TEZ/D-IVA----1件: 299
73VX-445 / TEZ / IVA----1件: 299
74VX-445 / TEZ / IVA FDC----1件: 299
75VX-445 /TEZ/IVA----1件: 299
76VX-445/TEZ/IVA----1件: 299
77VX-659/ TEZ/IVA1件: VX-659---1件: 299
78VX-659/TEZ/IVA1件: VX-659---1件: 299
79VX-659/Tezacaftor/Ivacaftor3件: Ivacaftor,
Tezacaftor,
VX-659		2件: D09916 (Name: Ivacaftor),
D11041 		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
80VX-661 Plus Ivacaftor Combination1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
81VX-661/Ivacaftor1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
82VX-661/ivacaftor (VX-770) 100mg/150 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
83VX-661/ivacaftor 100 mg/ 150 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
84VX-661/ivacaftor 100mg/150 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
85VX-661/ivacaftor 100mg/150mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
86VX-661/ivacaftor 50 mg/ 75 mg1件: Ivacaftor1件: D09916 (Name: Ivacaftor)1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299
87VX-661/VX-770 (TEZ/IVA)----1件: 299