KEGG DRUG

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No.	薬物名（臨床試験情報から抽出）	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY	指定難病告示番号
1	Methotrexate(MTX)	1件: Methotrexate	1件: D00142	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬	1件: 46
2	Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol	1件: Methotrexate	1件: D00142	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬	1件: 46
3	Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.	1件: Methotrexate	1件: D00142	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬	1件: 46
4	Tocilizumab + methotrexate(MTX)	2件: Methotrexate, Tocilizumab	2件: D00142 , D02596	3件: DHFR, DHFR2, IL6R 💬	17件: Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬	1件: 46
5	Tocilizumab+Methotrexate(MTX)	2件: Methotrexate, Tocilizumab	2件: D00142 , D02596	3件: DHFR, DHFR2, IL6R 💬	17件: Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬	1件: 46