Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)
(Synonym: Otrexup (TN))		2件: Abatacept,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D03203 		4件: CD80,
CD86,
DHFR,
DHFR2 💬		18件: Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬1件: 46
2Abatacept + Methotrexate
(Synonym: Otrexup (TN))		2件: Abatacept,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D03203 		4件: CD80,
CD86,
DHFR,
DHFR2 💬		18件: Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬1件: 46
3Adalimumab 40 mg sc every other week1件: Adalimumab1件: D02597 1件: TNF 💬67件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 271
4Adalimumab 40 mg subcutaneous (SC) every other week (EOW)1件: Adalimumab1件: D02597 1件: TNF 💬67件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
5Adalimumab with methotrexate
(Synonym: Otrexup (TN))		2件: Adalimumab,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D02597 		3件: DHFR,
DHFR2,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
6Allo-APZ2-OTS----1件: 36
7Any other approved Antiepileptic Drug----1件: 144
8Apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side1件: Sinecatechins1件: D08997 --1件: 160
9Apremilast
(Synonym: Otezla (TN))		1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬7件: 46, 50, 56, 97, 107, 162, 271
10Apremilast (CC-10004)
(Synonym: Otezla (TN))		1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 56
11Apremilast 10 mg
(Synonym: Otezla (TN))		1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬2件: 56, 107
12Apremilast 20 mg
(Synonym: Otezla (TN))		1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬3件: 46, 56, 107
13Apremilast 30 mg
(Synonym: Otezla (TN))		1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬3件: 46, 56, 107
14Apremilast 30mg
(Synonym: Otezla (TN))		1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 50
15Apremilast tablet 20 mg
(Synonym: Otezla (TN))		1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 271
16Apremilast tablet 30 mg BID
(Synonym: Otezla (TN))		1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 271
17AZATHIOPRINE or METHOTREXATE
(Synonym: Otrexup (TN))		2件: Azathioprine,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D00238 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 96
18Baricitinib
(Synonym: OTHER BARICITINIB)		1件: Baricitinib1件: D10308 (Name: OTHER BARICITINIB)2件: JAK1,
JAK2 💬		35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬13件: 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
19Baricitinib 2 MG
(Synonym: OTHER BARICITINIB)		1件: Baricitinib1件: D10308 (Name: OTHER BARICITINIB)2件: JAK1,
JAK2 💬		35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬2件: 46, 53
20Baricitinib 2 MG [Olumiant]
(Synonym: OTHER BARICITINIB)		1件: Baricitinib1件: D10308 (Name: OTHER BARICITINIB)2件: JAK1,
JAK2 💬		35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 162
21Baricitinib 4 MG
(Synonym: OTHER BARICITINIB)		1件: Baricitinib1件: D10308 (Name: OTHER BARICITINIB)2件: JAK1,
JAK2 💬		35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46
22Baricitinib treatment
(Synonym: OTHER BARICITINIB)		1件: Baricitinib1件: D10308 (Name: OTHER BARICITINIB)2件: JAK1,
JAK2 💬		35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46
23Baricitinib, olumiant®
(Synonym: OTHER BARICITINIB)		1件: Baricitinib1件: D10308 (Name: OTHER BARICITINIB)2件: JAK1,
JAK2 💬		35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46
24BMN 110 - Every Other Week----1件: 19
25BMN 110 Every Other Week----1件: 19
26BMS-582949 and Methotrexate
(Synonym: Otrexup (TN))		2件: BMS-582949,
Methotrexate (Synonym: Otrexup)		1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
27Bromocriptine and other dopamine agonists2件: Bromocriptine,
Dopamine		2件: D03165 ,
D07870 		6件: DRD1,
DRD2,
DRD3,
DRD4,
DRD5,
PRL 💬		15件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
28Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF
(Synonym: Otrexup (TN))		6件: Busulfan,
Filgrastim,
Fludarabine,
Methotrexate (Synonym: Otrexup),
Phosphate ion,
Tacrolimus		6件: D00107 ,
D00142 (Name: Otrexup (TN)),
D00248 ,
D03235 ,
D07966 ,
D08556 		9件: CSF3R,
DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬		48件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, Nucleotide metabolism, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬1件: 60
29Certolizumab Pegol + Methotrexate (MTX)
(Synonym: Otrexup (TN))		2件: Certolizumab pegol,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D03441 		3件: DHFR,
DHFR2,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
30Cipro (Ciprofloxacin, BAYQ3939)
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
31Ciprofloxacin
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--5件: 2, 60, 96, 97, 299
32Ciprofloxacin (BAYQ3939) dry powder for inhalation
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
33Ciprofloxacin (Cipro Inhale, BAYQ3939)
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
34Ciprofloxacin (Cipro, BAYQ3939)
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
35Ciprofloxacin (ciproxin)
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
36Ciprofloxacin dispersion for inhalation
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
37Ciprofloxacin DPI
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
38Ciprofloxacin DPI (BAYQ3939)
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
39Ciprofloxacin for Inhalation
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
40Ciprofloxacin hydrochloride
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--2件: 96, 299
41CIPROFLOXACIN HYDROCHLORIDE MONOHYDRATE
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
42Ciprofloxacin Inhale
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
43Clobetasol propionate + Methotrexate
(Synonym: Otrexup (TN))		3件: Clobetasol,
Clobetasol propionate,
Methotrexate (Synonym: Otrexup)		3件: D00142 (Name: Otrexup (TN)),
D01272 ,
D07715 		3件: DHFR,
DHFR2,
NR3C1 💬		6件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬1件: 162
44Combination Product: Exercise, and methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
45Combination Product: Laser, exercise, and methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
46Combination Product: Methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
47CP-690,550 + methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
48Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids
(Synonym: Otrexup (TN))		3件: Azathioprine,
Cyclophosphamide,
Methotrexate (Synonym: Otrexup)		4件: D00142 (Name: Otrexup (TN)),
D00238 ,
D00287 ,
D07760 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44
49Cyclosporin, Methotrexate (GVHD prophylaxis)
(Synonym: Otrexup (TN))		2件: Cyclosporine,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D00184 		7件: DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		38件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬1件: 326
50DMARDs (methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
51Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase
(Synonym: Otrexup (TN))		4件: Asparaginase Escherichia coli,
Cyclophosphamide,
Doxorubicin,
Methotrexate (Synonym: Otrexup)		4件: D00142 (Name: Otrexup (TN)),
D00287 ,
D03899 ,
D07760 		4件: DHFR,
DHFR2,
TOP2A,
TOP2B 💬		6件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Platinum drug resistance 💬1件: 65
52Early immunosuppressants (azathioprine, methotrexate)
(Synonym: Otrexup (TN))		2件: Azathioprine,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D00238 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 96
53Enalapril and other angiotensin converting enzyme inhibitors2件: Angiotensin II,
Enalapril		3件: D00150 ,
D02014 ,
D07892 		3件: ACE,
AGTR1,
AGTR2 💬		18件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 19
54Etanercept + Methotrexate
(Synonym: Otrexup (TN))		2件: Etanercept,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D00742 		4件: DHFR,
DHFR2,
LTA,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
55Etanercept , Methotrexate
(Synonym: Otrexup (TN))		2件: Etanercept,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D00742 		4件: DHFR,
DHFR2,
LTA,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
56Etanercept, methotrexate and depomedrone
(Synonym: Otrexup (TN))		2件: Etanercept,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D00742 		4件: DHFR,
DHFR2,
LTA,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
57Etanercept, Methotrexate, Prednisolone
(Synonym: Otrexup (TN))		3件: Etanercept,
Methotrexate (Synonym: Otrexup),
Prednisolone		3件: D00142 (Name: Otrexup (TN)),
D00472 ,
D00742 		5件: DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬		72件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 56
58Etanercept, other Biologics, Disease-modifying antirheumatic drugs (DMARDs), etc1件: Etanercept1件: D00742 2件: LTA,
TNF 💬		67件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
59Ethylmethylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (**See other 2 names below)----1件: 6
60Ezetimibe + other lipid-lowering medication(s)1件: Ezetimibe1件: D01966 1件: NPC1L1 💬1件: Fat digestion and absorption 💬1件: 260
61Fixed dose combination Ciprofloxacin/Celecoxib
(Synonym: Otiprio (TN))		2件: Celecoxib,
Ciprofloxacin (Synonym: Otixal)		2件: D00186 (Name: Otiprio (TN)),
D00567 		1件: PTGS2 💬22件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 2
62Fluocinolone Acetonide
(Synonym: FLAC OTIC OIL)		2件: Fluocinolone,
Fluocinolone acetonide (Synonym: Flac Otic Oil)		1件: D01825 (Name: FLAC OTIC OIL)1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 90
63GSK3196165 (Otilimab)1件: Otilimab1件: D11343 (Name: Otilimab)1件: CSF2 💬16件: Acute myeloid leukemia, Amoebiasis, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, IL-17 signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Natural killer cell mediated cytotoxicity, Rheumatoid arthritis, Shigellosis, T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer 💬1件: 46
64Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)
(Synonym: Otrexup (TN))		4件: Azathioprine,
Methotrexate (Synonym: Otrexup),
Mycophenolate mofetil,
Mycophenolic acid		4件: D00142 (Name: Otrexup (TN)),
D00238 ,
D00752 ,
D05096 		4件: DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬		8件: Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬1件: 49
65Infliximab + methotrexate (MTX)
(Synonym: Otrexup (TN))		2件: Infliximab,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D02598 		3件: DHFR,
DHFR2,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
66Infliximab plus methotrexate
(Synonym: Otrexup (TN))		2件: Infliximab,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D02598 		3件: DHFR,
DHFR2,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 107
67Infliximab, methylprednisolone, methotrexate
(Synonym: Otrexup (TN))		3件: Infliximab,
Methotrexate (Synonym: Otrexup),
Methylprednisolone		3件: D00142 (Name: Otrexup (TN)),
D00407 ,
D02598 		4件: DHFR,
DHFR2,
NR3C1,
TNF 💬		72件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
68Infusion of autologous cryopreserved EFS-ADA LV CD34+ cells (OTL-101)----1件: 65
69Intrathecal methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 13
70L01X - Other antineoplastic agents----1件: 85
71Losartan and other angiotensin receptor blockers2件: Angiotensin II,
Losartan		3件: D00150 ,
D02014 ,
D08146 		2件: AGTR1,
AGTR2 💬		16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 19
72M2951 (Other Name: Evobrutinib)1件: Evobrutinib1件: D12467 1件: BTK 💬7件: B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬1件: 49
73Methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
74Methotrexate 'Lederle' 2,5mg tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
75Methotrexate 'Lederle' 2.5mg Tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
76Methotrexate 'Lederle' Tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
77Methotrexate (Metoject® prefilled pen)
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
78Methotrexate (MTX)
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
79Methotrexate (stable dose)
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
80Methotrexate (tapering dose)
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
81Methotrexate + Infliximab
(Synonym: Otrexup (TN))		2件: Infliximab,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D02598 		3件: DHFR,
DHFR2,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
82Methotrexate + Methylprednisolone
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Methylprednisolone		2件: D00142 (Name: Otrexup (TN)),
D00407 		3件: DHFR,
DHFR2,
NR3C1 💬		6件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬1件: 46
83METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 96
84Methotrexate - Amneal
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
85Methotrexate - DAVA
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
86Methotrexate - Delay
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
87Methotrexate - etanercept - prednisolone arm
(Synonym: Otrexup (TN))		3件: Etanercept,
Methotrexate (Synonym: Otrexup),
Prednisolone		3件: D00142 (Name: Otrexup (TN)),
D00472 ,
D00742 		5件: DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬		72件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬2件: 46, 107
88Methotrexate - Immediate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
89Methotrexate 10 mg
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
90Methotrexate 10 mg tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
91Methotrexate 2.5 mg
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44
92METHOTREXATE 2.5 mg tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
93Methotrexate 2.5mg Tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
94Methotrexate 2.5mg Tablets BP
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
95Methotrexate 25 mg
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44
96Methotrexate 50mg/ml solution for injection, pre-filled syringe
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
97Methotrexate ``Lederle`` 2.5mg tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
98Methotrexate alone
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 107
99Methotrexate and folic acid
(Synonym: Otrexup (TN))		2件: Folic acid,
Methotrexate (Synonym: Otrexup)		2件: D00070 ,
D00142 (Name: Otrexup (TN))		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 49
100Methotrexate as methotrexate disodium
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
101Methotrexate bellon
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 97
102Methotrexate bellon 25mg/ml
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 97
103Methotrexate capsules
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
104METHOTREXATE DISODIUM
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬5件: 46, 96, 97, 107, 271
105Methotrexate Ebewe
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
106METHOTREXATE HOSPIRA 2,5 mg tablety
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
107METHOTREXATE HOSPIRA 2.5 mg tablety
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
108Methotrexate injection
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬2件: 96, 97
109Methotrexate Lachema 5inj. sol
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 50
110Methotrexate Lederle 2.5 mg Tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
111Methotrexate Pfizer 2,5 mg tabletter
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
112Methotrexate Placebo
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
113Methotrexate plus ENBREL or ENBREL alone
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
114Methotrexate plus ERB-041 for 12 weeks
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
115Methotrexate plus sulfasalazine
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Sulfasalazine		2件: D00142 (Name: Otrexup (TN)),
D00448 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
116Methotrexate pre-filled pen
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
117Methotrexate prefilled pen
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
118Methotrexate prefilled syringe
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
119METHOTREXATE SODIUM
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬2件: 46, 256
120Methotrexate Sodium 2.5mg Tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
121Methotrexate Sodium Tablets 2.5 mg
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
122Methotrexate Sodium Tablets 2.5mg
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
123Methotrexate Tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬2件: 40, 46
124Methotrexate tablets 2.5 mg
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
125Methotrexate treatment
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬2件: 41, 46
126Methotrexate Wyeth 2,5mg
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 50
127Methotrexate Wyeth 2,5mg tbl.
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 50
128Methotrexate ® 2.5mg Tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
129Methotrexate(MTX)
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
130Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
131Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
132Methotrexate(necessary)
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
133METHOTREXATE*100CPR 2,5MG
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
134METHOTREXATE*10MG/1,33ML 4S
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
135METHOTREXATE*15MG/2ML 4SIR
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
136METHOTREXATE*2,5MG 25CPR
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
137METHOTREXATE*20MG/2,66ML 4S
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
138METHOTREXATE*25CPR 2,5MG
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬2件: 46, 107
139METHOTREXATE*7,5MG/ML 4SIR.
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
140Methotrexate, Leucovorin and BMS-986142
(Synonym: Otrexup (TN))		3件: BMS-986142,
Leucovorin,
Methotrexate (Synonym: Otrexup)		3件: D00142 (Name: Otrexup (TN)),
D07986 ,
D07987 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
141Methotrexate,Adalimumab
(Synonym: Otrexup (TN))		2件: Adalimumab,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D02597 		3件: DHFR,
DHFR2,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
142Methotrexate-Lachema
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
143Methotrexate-Sulfasalazine-Hydroxychloroquine
(Synonym: Otrexup (TN))		3件: Hydroxychloroquine,
Methotrexate (Synonym: Otrexup),
Sulfasalazine		3件: D00142 (Name: Otrexup (TN)),
D00448 ,
D08050 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
144Methotrexate® 2.5 mg tablets
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
145Methylprednisolone (or other glucocorticoid)1件: Methylprednisolone1件: D00407 1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 43
146Moderna COVID-19 Vaccine
(Synonym: OTHER MODERNA COVID-19 VACCINE)		1件: Moderna COVID-19 Vaccine1件: D12114 (Name: OTHER MODERNA COVID-19 VACCINE)--1件: 46
147MP-435(dose1) + Methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
148MSDMDs other than Betaseron (Interferon beta-1b, BAY86-5046)2件: Human interferon beta,
Interferon beta-1b		1件: D00746 2件: IFNAR1,
IFNAR2 💬		18件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬1件: 13
149Mycophenolate mofetil,methotrexate
(Synonym: Otrexup (TN))		3件: Methotrexate (Synonym: Otrexup),
Mycophenolate mofetil,
Mycophenolic acid		3件: D00142 (Name: Otrexup (TN)),
D00752 ,
D05096 		4件: DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬		8件: Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬3件: 42, 43, 45
150Oral ciprofloxacin
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
151Oral ciprofloxacin plus inhaled colistin
(Synonym: Otiprio (TN))		2件: Ciprofloxacin (Synonym: Otixal),
Colistin		2件: D00186 (Name: Otiprio (TN)),
D07746 		--1件: 299
152Oral methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
153OT----1件: 193
154Otelixizumab1件: Otelixizumab1件: D08959 (Name: Otelixizumab)3件: CD3D,
CD3E,
CD3G 💬		11件: Chagas disease, Epstein-Barr virus infection, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human immunodeficiency virus 1 infection, Measles, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation 💬1件: 46
155Otezla1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬3件: 56, 107, 162
156OTEZLA - 10 MG + 20 MG + 30 MG COMPRESSA RIVESTITA CON FILM USO ORALE - BLISTER (PVC/ALU) IN UN ASTUCCIO - 4 COMPRESSE DA 10 MG + 4 COMPRESSE DA 20 MG +19 COMPRESSE DA 30 MG1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬2件: 56, 107
157OTEZLA - 30 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/ALU) - 56 COMPRESSE1件: Apremilast (Synonym: Otezla)1件: D08860 (Name: Otezla (TN))4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 107
158Other analgesics and antipyretics----1件: 13
159Other antiepileptics----1件: 140
160Other Biologic Therapies----2件: 96, 97
161Other biological agent----2件: 46, 96
162Other Biologics----1件: 46
163Other COX-2 inhibitor----1件: 271
164Other Cox-2 inhibitors----1件: 271
165Other Crystalloid----1件: 296
166Other disease-modifying therapy----1件: 13
167Other H1 antagonist----1件: 13
168Other hematological Agents----1件: 65
169OTHER NERVOUS SYSTEM DRUGS----2件: 6, 13
170Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac1件: Etodolac1件: D00315 1件: PTGS2 💬22件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 46
171Other Non-selective NSAIDs----1件: 271
172Other non-sponsor pancreatic enzyme replacement therapy----1件: 299
173Other Parkinson's Disease treatments----1件: 6
174Other respiratory system products----1件: 299
175OTHER SOURCES----1件: 228
176Other vasodilator----1件: 51
177OTILIMAB1件: Otilimab1件: D11343 (Name: Otilimab)1件: CSF2 💬16件: Acute myeloid leukemia, Amoebiasis, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, IL-17 signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Natural killer cell mediated cytotoxicity, Rheumatoid arthritis, Shigellosis, T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer 💬1件: 46
178Otilimab (GSK3196165)1件: Otilimab1件: D11343 (Name: Otilimab)1件: CSF2 💬16件: Acute myeloid leukemia, Amoebiasis, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, IL-17 signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Natural killer cell mediated cytotoxicity, Rheumatoid arthritis, Shigellosis, T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer 💬1件: 46
179OTL-101----1件: 65
180OTL-103----1件: 65
181OTL-103 Dispersion for Infusion----1件: 65
182OTL-200----1件: 19
183OTL-200 Dispersion for Infusion----1件: 19
184OTL-200 Gene Therapy----1件: 19
185OTL38----1件: 46
186Phase 1: Methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
187PO ciprofloxacin
(Synonym: Otiprio (TN))		1件: Ciprofloxacin (Synonym: Otixal)1件: D00186 (Name: Otiprio (TN))--1件: 299
188Response to anakinra associated with methotrexate
(Synonym: Otrexup (TN))		2件: Anakinra,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D02934 		4件: DHFR,
DHFR2,
IL1R1,
IL1R2 💬		20件: Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬1件: 46
189Response to infliximab associated with methotrexate
(Synonym: Otrexup (TN))		2件: Infliximab,
Methotrexate (Synonym: Otrexup)		2件: D00142 (Name: Otrexup (TN)),
D02598 		3件: DHFR,
DHFR2,
TNF 💬		71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46
190Sedatives/Hypnotics,Other----1件: 107
191See D.3.9.3 'Other descriptive name' below----1件: 46
192Stable weekly dose of methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
193Tacrolimus with Methotrexate
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Tacrolimus		3件: D00107 ,
D00142 (Name: Otrexup (TN)),
D08556 		7件: DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		38件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬1件: 46
194TAK-715 and methotrexate
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
TAK-715		1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
195TAK-783 and methotrexate
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46
196Tasocitinib plus Methotrexate
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Tofacitinib		2件: D00142 (Name: Otrexup (TN)),
D09970 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46
197TNF-alpha antagonist and other biotherapy----1件: 46
198Tocilizumab + methotrexate(MTX)
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Tocilizumab		2件: D00142 (Name: Otrexup (TN)),
D02596 		3件: DHFR,
DHFR2,
IL6R 💬		17件: Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬1件: 46
199Tocilizumab plus methotrexate
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Tocilizumab		2件: D00142 (Name: Otrexup (TN)),
D02596 		3件: DHFR,
DHFR2,
IL6R 💬		17件: Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬1件: 46
200Tocilizumab+Methotrexate(MTX)
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Tocilizumab		2件: D00142 (Name: Otrexup (TN)),
D02596 		3件: DHFR,
DHFR2,
IL6R 💬		17件: Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬1件: 46
201Tofacitinib or Baricitinib
(Synonym: OTHER BARICITINIB)		2件: Baricitinib,
Tofacitinib		2件: D09970 ,
D10308 (Name: OTHER BARICITINIB)		4件: JAK1,
JAK2,
JAK3,
TYK2 💬		37件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46
202Tofacitinib with methotrexate
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Tofacitinib		2件: D00142 (Name: Otrexup (TN)),
D09970 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46
203Tofacitinib without methotrexate
(Synonym: Otrexup (TN))		2件: Methotrexate (Synonym: Otrexup),
Tofacitinib		2件: D00142 (Name: Otrexup (TN)),
D09970 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46
204Tofacitinib/baricitinib
(Synonym: OTHER BARICITINIB)		2件: Baricitinib,
Tofacitinib		2件: D09970 ,
D10308 (Name: OTHER BARICITINIB)		4件: JAK1,
JAK2,
JAK3,
TYK2 💬		37件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46
205Tozinameran
(Synonym: OTHER BNT162B2)		1件: Tozinameran1件: D11971 (Name: OTHER BNT162B2)--1件: 299
206Treatment with systemic therapy (methotrexate)
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 162
207Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level
(Synonym: Otrexup (TN))		1件: Methotrexate (Synonym: Otrexup)1件: D00142 (Name: Otrexup (TN))2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 46