Target Gene/Pathway Pathway / Gene
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No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
---|---|---|---|---|---|
1 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 7件: 17, 19, 46, 66, 86, 222, 224 💬 |
2 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 7件: 17, 19, 46, 66, 86, 222, 224 💬 |
3 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D00522 D00522 💬 |
Candesartan | 058 2件: 58, 67 💬 |
4 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D00626 D00626 💬 |
Candesartan cilexetil | 067 1件: 67 💬 |
5 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D00523 D00523 💬 |
Irbesartan | 066 4件: 66, 167, 168, 222 💬 |
6 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 17件: 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
7 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D11776 D11776 💬 |
Sparsentan | 066 3件: 66, 218, 222 💬 |
8 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D00627 D00627 💬 |
Telmisartan | 066 2件: 66, 67 💬 |
9 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
AGTR1 1件: AGTR1 💬 |
D00400 D00400 💬 |
Valsartan | 057 7件: 57, 58, 66, 75, 218, 222, 224 💬 |
10 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
CCN2 1件: CCN2 💬 |
D10969 D10969 💬 |
Pamrevlumab | 085 2件: 85, 113 💬 |
11 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
HDAC4 2件: HDAC4, HDAC5 💬 |
D06320 D06320 💬 |
Vorinostat | 075 2件: 75, 96 💬 |
12 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10604 D10604 💬 |
Binimetinib | 034 1件: 34 💬 |
13 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10405 D10405 💬 |
Cobimetinib | 280 1件: 280 💬 |
14 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D11675 D11675 💬 |
Mirdametinib | 034 1件: 34 💬 |
15 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D09666 D09666 💬 |
Selumetinib | 034 1件: 34 💬 |
16 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10175 D10175 💬 |
Trametinib | 002 4件: 2 , 34, 279, 280 💬 |
17 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
MTOR 1件: MTOR 💬 |
D02714 D02714 💬 |
Everolimus | 034 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 |
18 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
MTOR 1件: MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 40件: 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 |
19 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
MTOR 1件: MTOR 💬 |
D06068 D06068 💬 |
Temsirolimus | 013 1件: 13 💬 |
20 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D00227 D00227 💬 |
Aminophylline | 063 1件: 63 💬 |
21 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D07546 D07546 💬 |
Bucladesine | 246 1件: 246 💬 |
22 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D00528 D00528 💬 |
Caffeine | 002 8件: 2 , 6 , 21, 46, 78, 96, 97, 265 💬 |
23 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D01453 D01453 💬 |
Caffeine | 002 8件: 2 , 6 , 21, 46, 78, 96, 97, 265 💬 |
24 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D01896 D01896 💬 |
Cilostazol | 046 3件: 46, 51, 70 💬 |
25 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D07961 D07961 💬 |
Flavoxate | 226 1件: 226 💬 |
26 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D01385 D01385 💬 |
Ibudilast | 002 2件: 2 , 13 💬 |
27 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D04720 D04720 💬 |
Levosimendan | 002 1件: 2 💬 |
28 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D00417 D00417 💬 |
Milrinone | 294 1件: 294 💬 |
29 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D00371 D00371 💬 |
Theophylline | 236 2件: 236, 299 💬 |
30 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PDE3B 1件: PDE3B 💬 |
D06103 D06103 💬 |
Theophylline | 236 2件: 236, 299 💬 |
31 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PRKAA1 2件: PRKAA1, PRKAA2 💬 |
D04966 D04966 💬 |
Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 |
32 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
PRKCE 1件: PRKCE 💬 |
D09671 D09671 💬 |
Sotrastaurin | 097 1件: 97 💬 |
33 | Apelin signaling pathway 💬 Related to 12 target genes, 30 drugs (DrugBank) and 72 diseases in DDrare |
RAF1 1件: RAF1 💬 |
D08524 D08524 💬 |
Sorafenib | 034 2件: 34, 86 💬 |