Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)[2] Abatacept,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Abatacept 💬 		[4] CD80,
CD86,
DHFR,
DHFR2 💬 		[18] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[1] 46 💬
2Abatacept + Methotrexate[2] Abatacept,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Abatacept 💬 		[4] CD80,
CD86,
DHFR,
DHFR2 💬 		[18] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[1] 46 💬
3Adalimumab with methotrexate[2] Adalimumab,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Adalimumab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
4AZATHIOPRINE or METHOTREXATE[2] Azathioprine,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Azathioprine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
5BMS-582949 and Methotrexate[2] BMS-582949,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
6Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF[6] Busulfan,
Filgrastim,
Fludarabine,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Phosphate ion,
Tacrolimus		[6] Tacrolimus ,
Methotrexate (Methotrexate),
Busulfan ,
Filgrastim ,
Fludarabine ,
Tacrolimus 💬 		[9] CSF3R,
DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬 		[48] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, Nucleotide metabolism, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 60 💬
7Certolizumab Pegol + Methotrexate (MTX)[2] Certolizumab pegol,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Certolizumab pegol 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
8Clobetasol propionate + Methotrexate[3] Clobetasol,
Clobetasol propionate,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[3] Methotrexate (Methotrexate),
Clobetasol propionate ,
Clobetasol 💬 		[3] DHFR,
DHFR2,
NR3C1 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 162 💬
9Combination Product: Exercise, and methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
10Combination Product: Laser, exercise, and methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
11Combination Product: Methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
12CP-690,550 + methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
13Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids[3] Azathioprine,
Cyclophosphamide,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[4] Methotrexate (Methotrexate),
Azathioprine ,
Cyclophosphamide ,
Cyclophosphamide 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
14Cyclosporin, Methotrexate (GVHD prophylaxis)[2] Cyclosporine,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Cyclosporine 💬 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 326 💬
15DMARDs (methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
16Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase[4] Asparaginase Escherichia coli,
Cyclophosphamide,
Doxorubicin,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[4] Methotrexate (Methotrexate),
Cyclophosphamide ,
Doxorubicin ,
Cyclophosphamide 💬 		[4] DHFR,
DHFR2,
TOP2A,
TOP2B 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Platinum drug resistance 💬[1] 65 💬
17Early immunosuppressants (azathioprine, methotrexate)[2] Azathioprine,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Azathioprine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
18Etanercept + Methotrexate[2] Etanercept,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
19Etanercept , Methotrexate[2] Etanercept,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
20Etanercept, methotrexate and depomedrone[2] Etanercept,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
21Etanercept, Methotrexate, Prednisolone[3] Etanercept,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Prednisolone		[3] Methotrexate (Methotrexate),
Prednisolone ,
Etanercept 💬 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 56 💬
22Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)[4] Azathioprine,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Mycophenolate mofetil,
Mycophenolic acid		[4] Methotrexate (Methotrexate),
Azathioprine ,
Mycophenolate mofetil ,
Mycophenolic acid 💬 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		[8] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬[1] 49 💬
23Infliximab + methotrexate (MTX)[2] Infliximab,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
24Infliximab plus methotrexate[2] Infliximab,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 107 💬
25Infliximab, methylprednisolone, methotrexate[3] Infliximab,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Methylprednisolone		[3] Methotrexate (Methotrexate),
Methylprednisolone ,
Infliximab 💬 		[4] DHFR,
DHFR2,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
26Intrathecal methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 13 💬
27Methotrexat[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[4] 13, 46, 50, 96 💬
28Methotrexat 2,5 mg Tabletten medac[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
29Methotrexat HEXAL® 2,5 mg Tabletten[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
30Methotrexat Lachema 2,5mg[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
31Methotrexat Lachema 2,5mg tbl.[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
32Methotrexat Lachema 5 inj. sol[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
33METHOTREXAT Lederle - Tabletten[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
34Methotrexat Lederle 2.5mg tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
35Methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
36Methotrexate 'Lederle' 2,5mg tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
37Methotrexate 'Lederle' 2.5mg Tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
38Methotrexate 'Lederle' Tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
39Methotrexate (Metoject® prefilled pen)[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
40Methotrexate (MTX)[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
41Methotrexate (stable dose)[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
42Methotrexate (tapering dose)[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
43Methotrexate + Infliximab[2] Infliximab,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
44Methotrexate + Methylprednisolone[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Methylprednisolone		[2] Methotrexate (Methotrexate),
Methylprednisolone 💬 		[3] DHFR,
DHFR2,
NR3C1 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 46 💬
45METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
46Methotrexate - Amneal[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
47Methotrexate - DAVA[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
48Methotrexate - Delay[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
49Methotrexate - etanercept - prednisolone arm[3] Etanercept,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Prednisolone		[3] Methotrexate (Methotrexate),
Prednisolone ,
Etanercept 💬 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[2] 46, 107 💬
50Methotrexate - Immediate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
51Methotrexate 10 mg[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
52Methotrexate 10 mg tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
53Methotrexate 2.5 mg[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
54METHOTREXATE 2.5 mg tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
55Methotrexate 2.5mg Tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
56Methotrexate 2.5mg Tablets BP[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
57Methotrexate 25 mg[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
58Methotrexate 50mg/ml solution for injection, pre-filled syringe[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
59Methotrexate ``Lederle`` 2.5mg tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
60Methotrexate alone[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 107 💬
61Methotrexate and folic acid[2] Folic acid,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Folic acid ,
Methotrexate (Methotrexate) 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 49 💬
62Methotrexate as methotrexate disodium[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
63Methotrexate bellon[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97 💬
64Methotrexate bellon 25mg/ml[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97 💬
65Methotrexate capsules[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
66METHOTREXATE DISODIUM[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[5] 46, 96, 97, 107, 271 💬
67Methotrexate Ebewe[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
68METHOTREXATE HOSPIRA 2,5 mg tablety[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
69METHOTREXATE HOSPIRA 2.5 mg tablety[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
70Methotrexate injection[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 96, 97 💬
71Methotrexate Lachema 5inj. sol[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
72Methotrexate Lederle 2.5 mg Tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
73Methotrexate Pfizer 2,5 mg tabletter[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
74Methotrexate Placebo[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
75Methotrexate plus ENBREL or ENBREL alone[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
76Methotrexate plus ERB-041 for 12 weeks[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
77Methotrexate plus sulfasalazine[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Sulfasalazine		[2] Methotrexate (Methotrexate),
Sulfasalazine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
78Methotrexate pre-filled pen[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
79Methotrexate prefilled pen[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
80Methotrexate prefilled syringe[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
81METHOTREXATE SODIUM[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 256 💬
82Methotrexate Sodium 2.5mg Tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
83Methotrexate Sodium Tablets 2.5 mg[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
84Methotrexate Sodium Tablets 2.5mg[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
85Methotrexate Tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 40, 46 💬
86Methotrexate tablets 2.5 mg[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
87Methotrexate treatment[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 41, 46 💬
88Methotrexate Wyeth 2,5mg[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
89Methotrexate Wyeth 2,5mg tbl.[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
90Methotrexate ® 2.5mg Tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
91Methotrexate(MTX)[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
92Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
93Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
94Methotrexate(necessary)[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
95METHOTREXATE*100CPR 2,5MG[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
96METHOTREXATE*10MG/1,33ML 4S[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
97METHOTREXATE*15MG/2ML 4SIR[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
98METHOTREXATE*2,5MG 25CPR[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
99METHOTREXATE*20MG/2,66ML 4S[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
100METHOTREXATE*25CPR 2,5MG[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 107 💬
101METHOTREXATE*7,5MG/ML 4SIR.[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
102Methotrexate, Leucovorin and BMS-986142[3] BMS-986142,
Leucovorin,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[3] Methotrexate (Methotrexate),
Folinic acid ,
Folinic acid calcium salt pentahydrate 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
103Methotrexate,Adalimumab[2] Adalimumab,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Adalimumab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
104Methotrexate-Lachema[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
105Methotrexate-Sulfasalazine-Hydroxychloroquine[3] Hydroxychloroquine,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Sulfasalazine		[3] Methotrexate (Methotrexate),
Sulfasalazine ,
Hydroxychloroquine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
106Methotrexate® 2.5 mg tablets[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
107MP-435(dose1) + Methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
108Mycophenolate mofetil,methotrexate[3] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Mycophenolate mofetil,
Mycophenolic acid		[3] Methotrexate (Methotrexate),
Mycophenolate mofetil ,
Mycophenolic acid 💬 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		[8] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬[3] 42, 43, 45 💬
109Oral methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
110Phase 1: Methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
111Response to anakinra associated with methotrexate[2] Anakinra,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Anakinra 💬 		[4] DHFR,
DHFR2,
IL1R1,
IL1R2 💬 		[20] Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[1] 46 💬
112Response to infliximab associated with methotrexate[2] Infliximab,
Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
113Stable weekly dose of methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
114Tacrolimus with Methotrexate[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Tacrolimus		[3] Tacrolimus ,
Methotrexate (Methotrexate),
Tacrolimus 💬 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 46 💬
115TAK-715 and methotrexate[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
TAK-715		[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
116TAK-783 and methotrexate[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
117Tasocitinib plus Methotrexate[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
118Tocilizumab + methotrexate(MTX)[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
119Tocilizumab plus methotrexate[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
120Tocilizumab+Methotrexate(MTX)[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
121Tofacitinib with methotrexate[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
122Tofacitinib without methotrexate[2] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
123Treatment with systemic therapy (methotrexate)[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 162 💬
124Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level[1] Methotrexate (Methotrexate-pws Im IV Iar Int Ivr 20mg/vial)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬