13. 多発性硬化症／視神経脊髄炎 Multiple sclerosis/Neuromyelitis optica Clinical trials / Disease details

臨床試験数 : 3,340 / 薬物数 : 2,163 - (DrugBank : 383) / 標的遺伝子数 : 241 - 標的パスウェイ数 : 238

11 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2019-001549-42-GB (EUCTR)	27/03/2020	03/02/2020	Stem cell transplantation versus disease modifying therapy (alemtuzumab or ocrelizumab) for patients ...	A multicentre, randomised controlled trial to evaluate the efficacy of autologous haematopoietic ste ...	Highly active relapsing remitting multiple sclerosis MedDRA version: 20.1;Level: PT;Classification c ...	Product Name: Cyclophosphamide INN or Proposed INN: Cyclophosphamide monohydrate INN or Proposed INN: C ...	Sheffield Teaching Hospitals	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	198	Phase 3	United Kingdom
2	NCT03829566 (ClinicalTrials.gov)	November 2019	1/2/2019	Autologous Transplant To End NMO Spectrum Disorder	Autologous Hematopoietic Stem Cell Transplant for Neuromyelitis Optica Spectrum Disorder (NMOSD)	Neuromyelitis Optica;Devic's Disease;NMO Spectrum Disorder	Drug: Rituximab;Drug: Cyclophosphamide;Drug: Mesna;Drug: rATG;Drug: Methylprednisolone;Drug: G-CSF;B ...	Northwestern University	NULL	Withdrawn	18 Years	65 Years	All	0	Phase 2/Phase 3	United States
3	EUCTR2017-001362-25-NL (EUCTR)	30/09/2019	10/09/2019	Randomized study with stem cell transplantation versus standard treatment with alemtuzumab, cladribi ...	Randomized autologous hematopoietic stem cell transplantation versus alemtuzumab, cladribine or ocre ...	Relapsing remitting multiple sclerosis. MedDRA version: 21.1;Level: PT;Classification code 10063399; ...	Trade Name: Cyclophosphamide Product Name: Cyclophosphamide INN or Proposed INN: CYCLOPHOSPHAMIDE Trade ...	Helse Bergen HF, Haukeland University Hospital	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	100	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (P ...	Denmark;Netherlands
4	EUCTR2017-001362-25-DK (EUCTR)	27/06/2018	21/03/2018	Randomized study with stem cell transplantation versus standard treatment with alemtuzumab, cladribi ...	Randomized autologous hematopoietic stem cell transplantation versus alemtuzumab, cladribine or ocre ...	Relapsing remitting multiple sclerosis. MedDRA version: 21.1;Level: PT;Classification code 10063399; ...	Trade Name: Sendoxane Product Name: Cyclophosphamide Trade Name: Thymoglobuline ® Product Name: Thymoglo ...	Helse Bergen HF, Haukeland University Hospital	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	100	Phase 3	Denmark;Netherlands
5	EUCTR2017-001362-25-SE (EUCTR)	02/05/2018	17/10/2017	Randomized study with stem cell transplantation versus standard treatment with alemtuzumab, cladribi ...	Randomized autologous hematopoietic stem cell transplantation versus alemtuzumab, cladribine or ocre ...	Relapsing remitting multiple sclerosis. MedDRA version: 21.1;Level: PT;Classification code 10063399; ...	Trade Name: Sendoxane Product Name: Cyclophosphamide Trade Name: Thymoglobuline ® Product Name: Thymoglo ...	Helse Bergen HF, Haukeland University Hospital	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	100	Phase 3	Denmark;Netherlands;Sweden
6	NCT03342638 (ClinicalTrials.gov)	November 8, 2017	9/11/2017	Maximizing Outcome of Multiple Sclerosis Transplantation	Maximizing Outcome of Multiple Sclerosis Transplantation: MOST Trial	Multiple Sclerosis, Relapsing-Remitting	Drug: Cyclophosphamide;Drug: Mesna;Drug: rATG;Drug: Methylprednisolone;Drug: G-CSF;Biological: IVIg; ...	Northwestern University	NULL	Terminated	18 Years	58 Years	All	66	Phase 3	United States
7	EUCTR2010-023560-40-SE (EUCTR)	23/03/2011	21/12/2010	Blood stem cell transplantation for patients with relapsiong-remitting multiple sclerosis, in whom s ...	Haematopoetic Stem Cell Therapy for Patients with Inflammatory Multiple Sclerosis Failing Alternate ...	Relapsing-remitting multiple sclerosis MedDRA version: 13.1;Level: PT;Classification code 10063399;T ...	Trade Name: Tysabri INN or Proposed INN: NATALIZUMAB Trade Name: Sendoxan Other descriptive name: CYCLO ...	Uppsala l?ns landsting	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	120		United States;Canada;Brazil;Sweden
8	NCT00716066 (ClinicalTrials.gov)	June 2008	15/7/2008	Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases	High-Dose Immunosuppressive Therapy Using Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) + ...	Autoimmune Disease;Neurologic Autoimmune Disease;Autologous Transplant Autoimmune;Multiple Sclerosis ...	Biological: Anti-Thymocyte Globulin;Procedure: Autologous Hematopoietic Stem Cell Transplantation;Dr ...	Fred Hutchinson Cancer Center	NULL	Recruiting	N/A	71 Years	All	80	Phase 2	United States
9	NCT00288626 (ClinicalTrials.gov)	July 2006	7/2/2006	High-Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis (HALT MS) Study	A Phase II Study of High-Dose Immunosuppressive Therapy Using Carmustine, Etoposide, Cytarabine, Mel ...	Relapsing-Remitting Multiple Sclerosis	Drug: Granulocyte-colony stimulating factor (G-CSF) and prednisone;Drug: Carmustine , etoposide, cyta ...	National Institute of Allergy and Infectious Diseases (NIAID)	Immune Tolerance Network (ITN)	Completed	18 Years	60 Years	All	25	Phase 2	United States
10	EUCTR2006-002562-19-IT (EUCTR)	21/04/2006	24/01/2007	Immunoablation with Cyclophosphamide at high dosage and Rabbit antithymoglobulin followed by autolog ...	Immunoablation with Cyclophosphamide at high dosage and Rabbit antithymoglobulin followed by autolog ...	VERIFICARE Patients with multiple sclerosis, age between 18 and 50 MedDRA version: 6.1;Level: PT;Cla ...	Trade Name: L04AA04 - IMMUNOGLOBULINA ANTITIMOCITARIA (DI CONIGLIO) IMMUNOGLOBULINA DI CONIGLIO ANTI ...	Dipartimento di Neuroscienze Oftalmologia e Genetica DINOG - Universita di Genova	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	12		Italy

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