171. ウィルソン病 Wilson disease Clinical trials / Disease details

臨床試験数 : 79 / 薬物数 : 77 - (DrugBank : 17) / 標的遺伝子数 : 6 - 標的パスウェイ数 : 30

29 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05686564 (ClinicalTrials.gov)	January 30, 2023	6/1/2023	Early Access Program for ALXN1840 in Patients With Wilson Disease	Early Access Program for ALXN1840 in Patients With Wilson Disease.	Wilson Disease	Drug: ALXN1840	Alexion	NULL	Available	3 Years	N/A	All			NULL
2	EUCTR2021-001015-82-DE (EUCTR)	26/11/2021	10/08/2021	Phase 3, open-label study of ALXN1840versus standard of care in pediatric participants with Wilson d ...	A multicenter, randomized, controlled, open-label, rater-blinded study to evaluate efficacy, safety, ...	Wilson Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease;S ...	Product Name: ALXN1840 Product Code: ALXN1840 INN or Proposed INN: tiomolibdic acid Other descriptive n ...	Alexion Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	48	Phase 3	France;United States;Canada;Spain;Poland;Australia;Germany;United Kingdom;Japan;Korea, Republic of
3	EUCTR2021-001015-82-ES (EUCTR)	22/11/2021	23/08/2021	Phase 3, open-label study of ALXN1840versus standard of care in pediatric participants with Wilson d ...	A multicenter, randomized, controlled, open-label, rater-blinded study to evaluate efficacy, safety, ...	Wilson Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease;S ...	Product Name: ALXN1840 Product Code: ALXN1840 INN or Proposed INN: tiomolibdic acid Other descriptive n ...	Alexion Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	48	Phase 3	United Kingdom;France;Hungary;Canada;Poland;Australia;Denmark;Netherlands;Germany;Japan;Korea, Repub ...
4	NCT05047523 (ClinicalTrials.gov)	October 6, 2021	9/9/2021	Study of ALXN1840 Versus Standard of Care in Pediatric Participants With Wilson Disease	A Multicenter, Randomized, Controlled, Open-label, Rater-blinded Study to Evaluate Efficacy, Safety, ...	Wilson Disease	Drug: ALXN1840;Drug: Standard of Care	Alexion	NULL	Recruiting	3 Years	17 Years	All	48	Phase 3	Australia;France;Germany;Japan;Korea, Republic of;Poland;Spain;United Kingdom
5	EUCTR2020-005832-31-DK (EUCTR)	13/04/2021	01/02/2021	The effect of ALXN1840 on uptake of copper in the liver as measured by copper PET/CT scan.	Efficacy of ALXN1840on human hepatic copper uptake quantified with 64CuCl2 PET/CT-scan. - ALXN1840-H ...	Healthy Volunteers (Wilson's disease) MedDRA version: 22.0;Level: SOC;Classification code 10022891;T ...	Trade Name: Cuprior 150 mg INN or Proposed INN: TRIENTINE DIHYDROCHLORIDE Other descriptive name: Cuprio ...	Alexion Pharmaceuticals Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	32	Phase 2	Denmark
6	EUCTR2021-000102-25-DK (EUCTR)	09/04/2021	01/02/2021	The effect of ALXN1840 on excretion of copper in gall as measured by copper PET/MR-scan.	Efficacy of ALXN1840on human biliary copper excretion quantified with 64CuCl2 PET/MR-scan - ALXN1840 ...	Wilson's Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease ...	Product Name: ALXN1840 INN or Proposed INN: ALXN1840 Other descriptive name: BIS-CHOLINE TETRATHIOMOLY ...	Aarhus University Hospital	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	5	Phase 2	Denmark
7	EUCTR2019-003711-60-DE (EUCTR)	15/01/2021	02/06/2020	A Phase 2 clinical study to assess copper levels and liver changes in patients with Wilson disease w ...	A Phase 2, single-arm, pathologist-blinded study using liver biopsy specimens to assess copper conce ...	Wilson's Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease ...	Product Name: ALXN1840 Product Code: ALXN1840 INN or Proposed INN: Not applied Other descriptive name: ...	Alexion Pharmaceuticals, Inc	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	28	Phase 2	United States;Serbia;Spain;Turkey;Austria;Russian Federation;United Kingdom;France;Canada;Belgium;Po ...
8	NCT04422431 (ClinicalTrials.gov)	December 2, 2020	22/5/2020	Copper Concentration & Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease T ...	A Phase 2, Single-arm Pathologist-blinded 48-week Study Using Liver Biopsy Specimens to Assess Coppe ...	Wilson Disease	Drug: Bis-Choline Tetrathiomolybdate	Alexion Pharmaceuticals	NULL	Active, not recruiting	18 Years	N/A	All	31	Phase 2	United States;Denmark;New Zealand;Russian Federation;Singapore;Spain;United Kingdom;Australia;Austri ...
9	EUCTR2019-003711-60-FR (EUCTR)	22/10/2020	20/08/2020	A Phase 2 clinical study to assess copper levels and liver changes in patients with Wilson disease w ...	A Phase 2, single-arm, pathologist-blinded study using liver biopsy specimens to assess copper conce ...	Wilson's Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease ...	Product Name: ALXN1840 Product Code: ALXN1840 INN or Proposed INN: Not applied Other descriptive name: ...	Alexion Pharmaceuticals, Inc	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	28	Phase 2	United States;Serbia;Spain;Turkey;Austria;Russian Federation;United Kingdom;France;Canada;Belgium;Po ...
10	NCT04526210 (ClinicalTrials.gov)	October 21, 2020	19/8/2020	Study of ALXN1840 on the Metabolism of a CYP2B6 Substrate in Healthy Participants	A Phase 1, Randomized, 2-Period, 2-Sequence, Cross-over Study to Determine the Effect of ALXN1840on ...	Wilson Disease	Drug: ALXN1840;Drug: Bupropion Hydrochloride	Alexion Pharmaceuticals	NULL	Completed	18 Years	50 Years	All	54	Phase 1	United States

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