224. 紫斑病性腎炎 Purpura nephritis Clinical trials / Disease details
臨床試験数 : 16 / 薬物数 : 43 - (DrugBank : 21) / 標的遺伝子数 : 15 - 標的パスウェイ数 : 58
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ChiCTR2000039686 | 2020-12-01 | 2020-11-05 | To evaluate the efficacy and safety of tacrolimus in the treatment of children with Henoch Schonlein purpura nephritis | A multicentre, randomized, prospective, observational study evaluating the efficacy and safety of tacrolimus in the treatment of Henoch Schonlein purpura nephritis in children at 24 weeks | Henoch Schonlein purpura nephritis | Experimental drug treatment group:Tacroximus capsule (trade name: Saifu X R), 0.1mg /kg/d, orally taken 1 hour before or 2-3 hours after meals twice a day for 24 weeks;Prednisone 1.5-2mg/kg/d was taken orally for 4 weeks and then changed to oral administration every other day for 4 weeks, gradually reducing the amount.;Control treatment group:Cyclophosphamide 8-10mg/ kg/d was given intravenously for 2 consecutive days, once every 2-4 weeks for 4 consecutive times, and once every 3 weeks for 2 consecutive times for 6 times in total.Prednisone 1.5-2mg/kg/d was taken orally with breakfast in the morning. ; | Shengjing Hospital of China Medical University | NULL | Recruiting | Both | Experimental drug treatment group:156;Control treatment group:78; | Phase 4 | China | ||
| 2 | ChiCTR2200055323 | 2016-08-01 | 2022-01-07 | Efficacy and safety of tacrolimus in the treatment of children with allergic purpura nephritis | Efficacy and safety of tacrolimus in the treatment of children with allergic purpura nephritis | Allergic purpuric nephritis in children | Tacrolimus group:Tacrolimus;Cyclophosphamide group:Cyclophosphamide;Mycophenolate mofetil group:Mycophenolate mofetil; | Lanzhou University Second Hospital | NULL | Completed | 4 | 18 | Both | Tacrolimus group:31;Cyclophosphamide group:31;Mycophenolate mofetil group:30; | Phase 4 | China |
| 3 | NCT03222687 (ClinicalTrials.gov) | September 1, 2015 | 7/7/2017 | Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis | Off-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and Safety | Henoch-Schönlein Purpura Nephritis | Drug: tacrolimus;Drug: prednisone | Shandong University | NULL | Completed | N/A | 18 Years | All | 25 | Phase 4 | NULL |