269. 化膿性無菌性関節炎・壊疽性膿皮症・アクネ症候群 Pyogenic arthritis Clinical trials / Disease details


臨床試験数 : 23 薬物数 : 30 - (DrugBank : 12) / 標的遺伝子数 : 15 - 標的パスウェイ数 : 106

  
3 trials found
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1NCT04274166
(ClinicalTrials.gov)
May 202112/2/2020Secukinumab for the Inflammatory Phase of Pyoderma GangrenosumThe Efficacy and Safety of Secukinumab for the Inflammatory Phase of Pyoderma GangrenosumPyoderma GangrenosumDrug: secukinumab 150 mg (2 injections per doseWake Forest University Health SciencesNovartisWithdrawn18 Years75 YearsAll0Phase 2United States
2NCT02733094
(ClinicalTrials.gov)
April 201628/3/2016Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma GangrenosumSingle-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma GangrenosumPyoderma GangrenosumDrug: SecukinumabTechnische Universität MünchenNovartisActive, not recruiting18 Years75 YearsAll8Phase 1/Phase 2Germany
3EUCTR2015-000762-65-DE
(EUCTR)
09/07/201525/06/2015Single-arm study to assess a potential effect of anti-IL-17 (Secukinumab) in the treatment of pyoderma gangrenosuSingle-arm study to assess a potential effect of anti-IL-17 (Secukinumab) in the treatment of pyoderma gangrenosum Pyoderma gangrenosum is an autoinflammatory disease, characterized by relapsing, painful ulcers of the skin. Treatment of PG is difficult. Patients suffer from long hospitalization, pain and reduced life quality. New therapeutic strategies are needed. Immunohistological staining show a high amount of IL-17 in PG. IL-17+ immune cells were located in proximity to cellular damage, indicating an involvement in the pathogenesis. Targeting IL-17 with neutralizing IL-17 antibodies seems promising.
MedDRA version: 20.0;Level: PT;Classification code 10037635;Term: Pyoderma gangrenosum;System Organ Class: 10040785 - Skin and subcutaneous tissue disorders;Therapeutic area: Diseases [C] - Skin and Connective Tissue Diseases [C17]
Trade Name: Cosentyx®
Product Name: Cosentyx
Product Code: EU/1/14/980/002; EU/1/14/980/003
Technische Universität München, School of Medicine, represented by DeanNULLNot RecruitingFemale: yes
Male: yes
7Phase 2;Phase 3Germany