280. 巨大動静脈奇形（頚部顔面又は四肢病変） Huge arteriovenous malformation with cervicofacial or limb lesion Clinical trials / Disease details

臨床試験数 : 27 / 薬物数 : 30 - (DrugBank : 15) / 標的遺伝子数 : 14 - 標的パスウェイ数 : 153

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05125471 (ClinicalTrials.gov)	July 26, 2022	12/11/2021	Cobimetinib In Extracranial Arteriovenous Malformations (COBI-AVM Study)	COBI-AVM Study - Phase 2 Study to Assess the Safety and Efficacy of Cobimetinib In Extracranial Arte ...	Arteriovenous Malformations (Extracranial)	Drug: Cobimetinib	University of Arkansas	Genentech, Inc.	Recruiting	2 Years	80 Years	All	17	Phase 2	United States
2	NCT04772963 (ClinicalTrials.gov)	February 2022	23/2/2021	Genetics of Central Nervous System Arteriovenous Malformations (GENE-MAV)	Genetics of Central Nervous System Arteriovenous Malformations (AVM): Genotype-Phenotype Correlation ...	Arteriovenous Malformations	Genetic: blood sample	Fondation Ophtalmologique Adolphe de Rothschild	NULL	Not yet recruiting	N/A	N/A	All	300		NULL
3	ChiCTR2100048193	2021-07-01	2021-07-04	Clinical study of bilateral uterine artery embolization versus surgical resection in the treatment o ...	Clinical study of bilateral uterine artery embolization versus surgical resection in the treatment o ...	Uterine arteriovenous malformation	Experimental group:Uterine arterial embolization;Control group:Surgical resection;	Henan Provincial People's Hospital	NULL	Pending			Female	Experimental group:10;Control group:10;	Phase 4	China
4	NCT04297033 (ClinicalTrials.gov)	January 1, 2021	21/2/2020	Lovastatin for Treatment of Brain Arteriovenous Malformations	Lovastatin for Treatment of Brain Arteriovenous Malformations:a Double-blind, Placebo-controlled Ran ...	Cerebral Arteriovenous Malformation	Drug: Lovastatin;Drug: Placebo	Beijing Tiantan Hospital	NULL	Not yet recruiting	18 Years	N/A	All	1244	Phase 2	China
5	ChiCTR2000036597	2020-10-01	2020-08-24	The safety and efficacy of embolization of jaw arteriovenous malformations: one center observational ...	The safety and efficacy of embolization of jaw arteriovenous malformations: one center observational ...	jaw arteriovenous malformations	group of bleeding:coils and absolute ethanol;group of no bleeding:coils and absolute ethanol;	Shanghai Ninth People Hospital, School of Medicine, Shanghai Jiaotong University	NULL	Pending	5	15	Both	group of bleeding:30;group of no bleeding:30;	N/A	China
6	ChiCTR2000036576	2020-09-01	2020-08-24	A randomized controlled trial for comparing the effect and outcomes with different embolic agent: Ab ...	A randomized controlled trial for comparing the effect and outcomes with different embolic agent: Ab ...	arteriovenous malformations	Group 1:absolute ethanol;Group 2:Oynx;	Shanghai Ninth People Hospital, School of Medicine, Shanghai Jiaotong University	NULL	Recruiting			Both	Group 1:30;Group 2:30;	N/A	China
7	NCT04999618 (ClinicalTrials.gov)	January 1, 2020	17/7/2021	A New Approach in Laser Surgery Using the Regenerative Solution in Children Diagnosed With Vascular ...	DOUBLE-SKIN: a New Approach in Laser Surgery Using the Regenerative Solution in Children Diagnosed W ...	Vascular Diseases;Vascular Malformation;Capillary Malformation-Arteriovenous Malformation;Port-Wine ...	Drug: Haemoblock;Other: Placebo	Center for Vascular Pathology, Moscow	NULL	Completed	6 Months	18 Years	All	200	Phase 4	Russian Federation
8	EUCTR2019-001530-33-FR (EUCTR)	29/06/2019	01/04/2019	TOPical sirolimus in linGUal microkystic lymphatic malformation-TOPGUN	TOPical sirolimus in linGUal microkystic lymphatic malformation-TOPGUN - TOPGUN	Lingual microcystic lymphatic malformations (LMLM) in children and adults MedDRA version: 20.0;Level ...	Trade Name: RAPAMUNE Product Name: Sirolimus 1mg/mL Product Code: L04AA10	CHRU TOURS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	12	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	France
9	ChiCTR1900021901	2019-03-20	2019-03-15	Efficacy and Safety of Thalidomide for the Treatment of Arteriovenous Malformations in Central Nervo ...	Efficacy and Safety of Thalidomide for the Treatment of Arteriovenous Malformations in Central Nervo ...	central nervous system arteriovenous malformations	Case series:Oral thalidomide;	Xuanwu Hospital, Capital Medical University	NULL	Completed			Both	Case series:30;		China
10	EUCTR2018-001359-11-FR (EUCTR)	22/02/2019	23/07/2018	0.1% topical sirolimus in the treatment of cutaneous microcystic lymphatic malformations in children ...	0.1% topical sirolimus in the treatment of cutaneous microcystic lymphatic malformations in children ...	Cutaneous microcystic lymphatic malformations (CMLM) in children and adults MedDRA version: 20.0;Lev ...	Product Name: Sirolimus 0,1% crème INN or Proposed INN: SIROLIMUS	CHRU TOURS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	55	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	France

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