294. 先天性横隔膜ヘルニア Congenital diaphragmatic hernia Clinical trials / Disease details
臨床試験数 : 16 / 薬物数 : 26 - (DrugBank : 5) / 標的遺伝子数 : 5 - 標的パスウェイ数 : 14
Showing 1 to 10 of 16 diseases
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
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1 | NCT05213676 (ClinicalTrials.gov) | January 1, 2023 | 27/1/2022 | Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia (CDH) - The NoNO Trial - a Multi-center, De-implementation, Stepped-wedge, Cluster-randomized Trial Within an Established Collaborative Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia(CDH) - The NoNO Trial - a Multi-cente ... | Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia (CDH) - The NoNO Trial - a Multi-center, De-implementation, Stepped-wedge, Cluster-randomized Trial Within an Established Collaborative Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia(CDH) - The NoNO Trial - a Multi-cente ... | Congenital Diaphragmatic Hernia | Drug: Inhaled Nitric Oxide (iNO) use;Other: De-implementation of Inhaled Nitric Oxide (iNO) use | The University of Texas Health Science Center, Houston | NULL | Not yet recruiting | N/A | 1 Month | All | 600 | Phase 4 | United States |
2 | NCT05201144 (ClinicalTrials.gov) | September 15, 2022 | 7/1/2022 | A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH) | A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH) | Congenital Diaphragmatic Hernia;Pulmonary Hypertension | Drug: Sildenafil Oral Suspension;Other: Placebo | University of Utah | NULL | Recruiting | N/A | N/A | All | 40 | Phase 2 | United States |
3 | ChiCTR2000037331 | 2020-09-01 | 2020-08-28 | AI-assisted diagnosis and treatment engine based on a fully structured congenital diaphragmatic hernia disease database AI-assisted diagnosis and treatment engine based on a fully structured congenital diaphragmatic hern ... | AI-assisted diagnosis and treatment engine based on a fully structured congenital diaphragmatic hernia disease database AI-assisted diagnosis and treatment engine based on a fully structured congenital diaphragmatic hern ... | Congenital diaphragmatic hernia | intervention group:sildenafil + conventional therapy;control group:conventional therapy; | Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine | NULL | Recruiting | 0 | 5 | Both | intervention group:100;control group:100; | China | |
4 | EUCTR2017-000421-13-IT (EUCTR) | 20/03/2020 | 06/10/2020 | Newborns with Congenital diaphragmatic hernia; iNO versus sildenafil | Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS Trial Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: a ... | Congenital diaphragmatic hernia with pulmonary hypertension MedDRA version: 20.0;Level: SOC;Classification code 10038738;Term: Respiratory, thoracic and mediastinal disorders;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Congenital diaphragmatic herniawith pulmonary hypertension MedDRA version: 20.0;Level: SOC;Classific ... | Trade Name: REVATIO - 0.8 MG/ML - SOLUZIONE INIETTABILE - USO ENDOVENOSO - FLACONCINO(VETRO) 1 FLACONCINO DA 20 ML Product Name: Sildenafil Product Code: [na] INN or Proposed INN: Sildenafil Trade Name: INALOSSIN - 800 PPM MOL/MOL GAS MEDICINALE COMPRESSO BOMBOLA IN ALLUMINIO CON VALVOLA VI DA 20 LITRI Product Name: INALOSSIN 800 PPM MOL/MOL GAS MEDICINALE COMPRESSO Product Code: [na] INN or Proposed INN: OSSIDO DI AZOTO Other descriptive name: Nitric oxide Trade Name: REVATIO - 0.8 MG/ML - SOLUZIONE INIETTABILE - USO ENDOVENOSO - FLACONCINO(VETRO) 1 FLACO ... | ERASMUS MEDICAL CENTER | NULL | Not Recruiting | Female: yes Male: yes | 330 | Phase 3 | Spain;Belgium;Austria;Norway;Netherlands;Germany;Italy;Sweden | ||
5 | NCT04031508 (ClinicalTrials.gov) | August 12, 2019 | 8/7/2019 | Effect of a Parenteral Emulsion With Omega3 on Neonates With PPHN and CDH | Effect of a Parenteral Emulsion With LC-PUFA Omega 3 on Clinical Outcomes, Inflammatory and Oxidative Stress Markers in Neonates With Persistent Pulmonary Hypertension Associated With Congenital Diaphragmatic Hernia Effect of a Parenteral Emulsion With LC-PUFA Omega 3 on Clinical Outcomes, Inflammatory and Oxidativ ... | Pulmonary Hypertension of Newborn;Diaphragm Defect | Combination Product: lipid injectable emulsion with Fish oil | Coordinación de Investigación en Salud, Mexico | University of Southampton;Universidad Nacional Autonoma de Mexico | Recruiting | 1 Hour | 15 Days | All | 70 | Phase 2 | Mexico |
6 | EUCTR2017-000421-13-BE (EUCTR) | 07/02/2019 | 19/02/2019 | Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil. Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Ni ... | Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS trial Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: a ... | Congenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Congenital diaphragmatic herniawith pulmonary hypertension;Therapeutic area: Diseases [C] - Congenit ... | Trade Name: revatio 0.8mg/ml solution for injection Trade Name: INOmax 800ppm mol/mol inhalatiegas INN or Proposed INN: NITRIC OXIDE Trade Name: Neophyr 1000ppm mol/mol Trade Name: revatio 0.8mg/ml solution for injection Trade Name: INOmax800ppm mol/mol inhalatiegas INN ... | Erasmus MC | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 330 | Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): yes Therapeutic use (Phase 4): no Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (P ... | Belgium;Austria;Netherlands | ||
7 | NCT03526588 (ClinicalTrials.gov) | August 1, 2018 | 27/4/2018 | Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH) Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diap ... | Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH) Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diap ... | Congenital Diaphragmatic Hernia | Biological: Autologous umbilical cord blood | The University of Texas Health Science Center, Houston | Texas Medical Center Regenerative Medicine Consortium | Recruiting | N/A | 7 Days | All | 20 | Phase 1 | United States |
8 | EUCTR2017-000421-13-AT (EUCTR) | 13/07/2018 | 08/05/2018 | Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil. Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Ni ... | Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS trial Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: a ... | Congenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Congenital diaphragmatic herniawith pulmonary hypertension;Therapeutic area: Diseases [C] - Congenit ... | Trade Name: revatio 0.8mg/ml solution for injection INN or Proposed INN: Sildenafil Trade Name: INOmax 800ppm mol/mol inhalatiegas INN or Proposed INN: NITRIC OXIDE Trade Name: revatio 0.8mg/ml solution for injection INN or Proposed INN: Sildenafil Trade Name: INOmax ... | Erasmus MC | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 330 | Phase 4 | Austria;Netherlands | ||
9 | NCT02951130 (ClinicalTrials.gov) | August 22, 2017 | 14/10/2016 | Milrinone in Congenital Diaphragmatic Hernia | Milrinone in Congenital Diaphragmatic Hernia | Congenital Diaphragmatic Hernia;Persistent Pulmonary Hypertension of the Newborn;Hypoxemic Respiratory Failure;Pulmonary Hypoplasia Congenital Diaphragmatic Hernia;Persistent Pulmonary Hypertension of the Newborn;Hypoxemic Respirato ... | Drug: Milrinone;Drug: Placebo (5% Dextrose) | NICHD Neonatal Research Network | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Recruiting | N/A | 168 Hours | All | 66 | Phase 2 | United States |
10 | EUCTR2017-000421-13-NL (EUCTR) | 27/07/2017 | 07/06/2017 | Treatment of high blood pressure in the lungs in newborns with a defect inthe diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil. Treatment of high blood pressure in the lungs in newborns with a defect inthe diaphragm; inhaled Nit ... | Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxideversus intravenous Sildenafil:an international randomized controlled trial - CoDiNOS trial Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxideversus intravenous Sildenafil:an ... | Congenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Congenital diaphragmatic herniawith pulmonary hypertension;Therapeutic area: Diseases [C] - Congenit ... | Trade Name: revatio 0.8mg/ml solution for injection Trade Name: INOmax 800ppm mol/mol inhalatiegas | Erasmus MC | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 90 | Phase 3 | Belgium;Austria;Norway;Netherlands;Sweden |