Multicenter study of therapeutic effects of Idebenone in patients with Leber hereditary optic neuropathy Multicenter study of therapeutic effects of Idebenonein patients with Leber hereditary optic neuropa ...
Multicenter study of therapeutic effects of Idebenone in patients with Leber hereditary optic neuropathy - Clinical trial of Idebenone in patients with LHON Multicenter study of therapeutic effects of Idebenonein patients with Leber hereditary optic neuropa ...
Leber hereditary optic neuropathy
1. Clinical trial medicine: Idebenone 900mg/day 2. Objectives: 50 patients with LHON 3. Exclusion criteria: a) A smoker b) A patient with abnormality of hepatic function c) A patient who present seizures, delirium and hallucination d) Pregnancy or Lactation e) A patient who is associated with agranulocytosis f) A patient with chronic renal failure g) A patient with anaphylactic shock against Idebenone 4. Duration of drug administration: 6 months 5. Examinations schedules: Both subjective and objective examinations are performed as following schedules; a) At the base line: Visual acuity (VA), Critical flicker frequency (CFF), Visual field (VF: Humphry 30-2), central retinal thickness (CRT), functional MRI (f-MRI), searching the mitochondrial mutation b) 8 weeks: VA, CFF, VF, CRT, f-MRI c) 16 weeks: VA, CFF, VF, CRT, f-MRI d) 24 weeks: VA, CFF, VF, CRT, f-MRI e) 32 weeks: VA, CFF, VF, CRT, f-MRI f) 40 weeks: VA, CFF, VF, CRT, f-MRI g) 48 weeks: VA, CFF, VF, CRT, f-MRI 1. Clinical trial medicine: Idebenone900mg/day 2. Objectives: 50 patients with LHON 3. Exclusion crit ...
Hyogo College of Medicine
Kitasato UniversityJikei University School of MedicineTokyo Medical University