40. 高安動脈炎 Takayasu arteritis Clinical trials / Disease details
臨床試験数 : 24 / 薬物数 : 40 - (DrugBank : 18) / 標的遺伝子数 : 23 - 標的パスウェイ数 : 110
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05168475 (ClinicalTrials.gov) | July 14, 2021 | 9/12/2021 | Biologics in Refractory Vasculitis | Biologics in Refractory Vasculitis (BIOVAS): A Pragmatic, Randomised, Double-blind, Placebo-controlled, Modified-crossover Trial of Biologic Therapy for Refractory Primary Non-ANCA Associated Vasculitis in Adults and Children | Giant Cell Arteritis;Takayasu Arteritis;Cogan Syndrome;Relapsing Polychondritis;Cryoglobulinemic Vasculitis;IgA Vasculitis;Polyarteritis Nodosa;Cutaneous Polyarteritis Nodosa;Primary Angiitis of Central Nervous System | Biological: Rituximab;Biological: Infliximab;Biological: Tocilizumab | Cambridge University Hospitals NHS Foundation Trust | NULL | Recruiting | 5 Years | N/A | All | 140 | Phase 2 | United Kingdom |
| 2 | NCT04564001 (ClinicalTrials.gov) | September 2020 | 21/9/2020 | Multicentre, Randomized, Prospective Trial Evaluating the Efficacy and Safety of Infliximab to Tocilizumab in Refractory or Relapsing Takayasu Arteritis | Multicentre, Randomized, Prospective Trial Evaluating the Efficacy and Safety of Infliximab to Tocilizumab in Refractory or Relapsing Takayasu Arteritis | Takayasu Arteritis | Drug: Infliximab;Drug: Tocilizumab | Assistance Publique - Hôpitaux de Paris | NULL | Not yet recruiting | 18 Years | N/A | All | 50 | Phase 2 | NULL |
| 3 | NCT04300686 (ClinicalTrials.gov) | March 1, 2020 | 5/3/2020 | A Pilot Study in Severe Patients With Takayasu Arteritis. | A Pilot Study in the Treatment of Severe Patients With Takayasu Arteritis With Tocilizumab and Adalimumab, Based on ECTA Cohort | Takayasu Arteritis;Tocilizumab;Adalimumab;Treatment | Biological: Tocilizumab;Biological: Adalimumab | Shanghai Zhongshan Hospital | NULL | Recruiting | 14 Years | 100 Years | All | 40 | Phase 4 | China |
| 4 | EUCTR2018-003753-13-FR (EUCTR) | 19/03/2019 | 13/12/2018 | INTOReTAK : INfliximab and TOcilizumab in Refractory/relapsing TAKayasu arteritis | Multicentre, randomized, prospective trial comparing the efficacy and safety of Infliximab to tocilizumab in refractory or relapsing Takayasu arteritis | Patients with refractory or relapsing Takayasu Arteritis desease;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02] | Trade Name: RoActemra 20mg/ml Product Name: Tocilizumab INN or Proposed INN: Tocilizumab Other descriptive name: TOCILIZUMAB Product Name: Infliximab INN or Proposed INN: INFLIXIMAB | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 50 | Phase 3 | France | ||
| 5 | JPRN-UMIN000025940 | 2017/02/07 | 07/02/2017 | Clinical Research on the Safety of anti-interleukin-6 antibody (Tocilizumab) treatment for the refractory patients with Takayasu Arteritis | Clinical Research on the Safety of anti-interleukin-6 antibody (Tocilizumab) treatment for the refractory patients with Takayasu Arteritis - TOCIlizumab treatment for TAKayasu arteritis (TOCI-TAK) | Takayasu arteritis | Intravenous administration of tocilizumab (8mg/kg/month) for up to 12 months | Osaka University | National Cerebral and Cardiovascular Center | Complete: follow-up continuing | 16years-old | 60years-old | Male and Female | 2 | Not selected | Japan |
| 6 | NCT03893136 (ClinicalTrials.gov) | November 1, 2016 | 12/3/2019 | The Registry Study of Takayasu Arteritis in East China | The Cohort Study of East Chinese Takayasu's Arteritis (ECTA-cohort Study) | Takayasu Arteritis;Mechanisms, Defense;Pregnancy Related;Treatment Refusal;Outcome | Biological: Tocilizumab;Drug: Leflunomide | Shanghai Zhongshan Hospital | NULL | Recruiting | 18 Years | 65 Years | All | 1000 | China | |
| 7 | JPRN-JapicCTI-142616 | 02/10/2014 | 23/07/2014 | Phase III Study of MRA-SC in Patients with Takayasu Arteritis | A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Phase III Study of MRA-SC in Patients with Takayasu Arteritis | Takayasu Arteritis | Intervention name : tocilizumab (MRA-SC) INN of the intervention : tocilizumab Dosage And administration of the intervention : 162mg/W, SC Control intervention name : Placebo INN of the control intervention : - Dosage And administration of the control intervention : Placebo/W, SC | Chugai Pharmaceutical Co., Ltd. | NULL | complete | 12 | BOTH | 34 | Phase 3 | Japan | |
| 8 | JPRN-UMIN000025943 | 2014/08/07 | 07/02/2017 | Long-term Safety of treatment with tocilizumab in the refractory patients with Takayasu Arteritis | Long-term Safety of treatment with tocilizumab in the refractory patients with Takayasu Arteritis - Long-term ACTemra Investigation for remissION introduction in TAKayasu Arteritits (LACTION-TAK) | Takayasu arteritis | Intravenous administration of tocilizumab (8mg/kg/month) will be performed until December 31st, 2017. | Osaka Unversity | National Cerebral and Cardiovascular Center | Complete: follow-up continuing | 16years-old | 60years-old | Male and Female | 9 | Not selected | Japan |
| 9 | NCT02101333 (ClinicalTrials.gov) | June 10, 2014 | 17/2/2014 | Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis | Efficacy and Tolerance of First-line Treatment With Tocilizumab in Active Takayasu Arteritis French Prospective Multicenter Study | TAKAYASU ARTERITIS | Drug: Tocilizumab | Assistance Publique - Hôpitaux de Paris | Chugai Pharmaceutical | Completed | 18 Years | 77 Years | All | 18 | Phase 3 | France |
| 10 | JPRN-UMIN000008812 | 2012/10/01 | 01/10/2012 | Efficacy and safety of tocilizumab mono-therapy in patients with large vessel vasculitis (LVV; giant cell arteritis or Takayasu arteritis) and polymyalgia rheumatica (PMR) | Efficacy and safety of tocilizumab mono-therapy in patients with large vessel vasculitis (LVV; giant cell arteritis or Takayasu arteritis) and polymyalgia rheumatica (PMR) - Treatment of LVV and PMR by tocilizumab mono-therapy | Rheumatoid arthritis | tocilizumab monotherapy | Department of Rheumatology & Clinical ImmunologySaitama Medical Center, Saitama Medical Universitity | NULL | Complete: follow-up complete | 16years-old | 80years-old | Male and Female | 40 | Not selected | Japan |
| 11 | JPRN-UMIN000007845 | 2012/05/01 | 01/05/2012 | Efficacy and Safety of treatment with tocilizumab in refractory patients with Takayasu Arteritis | Efficacy and Safety of treatment with tocilizumab in refractory patients with Takayasu Arteritis - ACTemra Investigation for remissiON introduction in Takayasu Arteritits (ACTION-TA) | Takayasu arteritis | Intravenous administration of tocilizumab (8mg/kg/month) for 24 months | Department of Cardiovascular Medicine Graduate School of Medicine Osaka University | NULL | Complete: follow-up continuing | 16years-old | 60years-old | Male and Female | 15 | Not selected | Japan |