44. 多発血管炎性肉芽腫症 Wegener granulomatosis Clinical trials / Disease details
臨床試験数 : 98 / 薬物数 : 108 - (DrugBank : 28) / 標的遺伝子数 : 22 - 標的パスウェイ数 : 81
Showing 1 to 10 of 98 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05376319 (ClinicalTrials.gov) | March 2023 | 11/5/2022 | PR3-AAV Resilient Remission or PRRR | A Randomized, Double-Blind, Active Comparator-Controlled Study to Evaluate the Effect of Obinutuzumab Versus Rituximab in PR3-Patients With Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis A Randomized, Double-Blind, Active Comparator-Controlled Study to Evaluate the Effect of Obinutuzuma ... | Granulomatosis With Polyangiitis;Microscopic Polyangiitis;ANCA Associated Vasculitis | Drug: Obinutuzumab;Drug: Rituximab | Mayo Clinic | NULL | Not yet recruiting | 18 Years | N/A | All | 30 | Phase 2 | United States |
| 2 | NCT04871191 (ClinicalTrials.gov) | March 2023 | 26/2/2021 | Study of Salvage Therapy to Treat Patients With Granulomatosis With Polyangiitis | Salvage Therapy for Patients With Inadequate Response to Standard of Care Therapy in Granulomatosis With Polyangiitis Salvage Therapy for Patients With Inadequate Response to Standard of Care Therapy in Granulomatosis ... | Granulomatosis With Polyangiitis;Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis | Drug: Rituximab;Drug: Tocilizumab;Drug: Abatacept | Assistance Publique - Hôpitaux de Paris | URC-CIC Paris Descartes Necker Cochin | Not yet recruiting | 18 Years | N/A | All | 42 | Phase 2 | France |
| 3 | EUCTR2021-005726-15-NL (EUCTR) | 02/12/2022 | 15/09/2022 | A study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) A study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults wi ... | A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) receiving standard of care (SoC) therapy - OCEAN A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority stu ... | Relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) receiving standard of care (SoC) therapy MedDRA version: 20.0;Level: PT;Classification code 10078117;Term: Eosinophilic granulomatosis with polyangiitis;System Organ Class: 10021428 - Immune system disorders;Therapeutic area: Diseases [C] - Immune System Diseases [C20] Relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis(EGPA) receiving standard of ca ... | Product Name: Depemokimab Product Code: GSK3511294 INN or Proposed INN: Depemokimab Trade Name: Nucala Product Name: Mepolizumab INN or Proposed INN: Mepolizumab Other descriptive name: Anti-interleukin 5 (IL-5) humanized monoclonal Product Name: Depemokimab Product Code: GSK3511294 INN or Proposed INN: Depemokimab Trade Name: Nucala P ... | GlaxoSmithKline Research & Development Limited | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 192 | Phase 3 | United States;Czechia;Finland;Spain;Austria;Russian Federation;Israel;United Kingdom;Italy;France;Hungary;Canada;Argentina;Belgium;Poland;Brazil;Australia;Germany;Netherlands;China;Japan;Sweden;Korea, Republic of United States;Czechia;Finland;Spain;Austria;Russian Federation;Israel;United Kingdom;Italy;France;Hu ... | ||
| 4 | NCT05263934 (ClinicalTrials.gov) | July 14, 2022 | 28/2/2022 | Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA) Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory ... | A 52-week, Randomized, Double-blind, Double-dummy, Parallel-group, Multi-centre, Non-inferiority Study to Investigate the Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA) Receiving Standard of Care (SoC) Therapy A 52-week, Randomized, Double-blind, Double-dummy, Parallel-group, Multi-centre, Non-inferiority Stu ... | Eosinophilic Granulomatosis With Polyangiitis | Biological: Depemokimab;Biological: Mepolizumab;Drug: Placebo matching mepolizumab;Drug: Placebo matching depemokimab Biological: Depemokimab;Biological: Mepolizumab;Drug: Placebo matching mepolizumab;Drug: Placebo mat ... | GlaxoSmithKline | NULL | Recruiting | 18 Years | N/A | All | 160 | Phase 3 | United States;Austria;Belgium;Canada;China;Czechia;France;Hungary;Italy;Japan;Korea, Republic of;Spain United States;Austria;Belgium;Canada;China;Czechia;France;Hungary;Italy;Japan;Korea, Republic of;Spa ... |
| 5 | EUCTR2021-005726-15-HU (EUCTR) | 12/07/2022 | 24/05/2022 | A study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) A study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults wi ... | A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) receiving standard of care (SoC) therapy - OCEAN A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority stu ... | Relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) receiving standard of care (SoC) therapy MedDRA version: 20.0;Level: PT;Classification code 10078117;Term: Eosinophilic granulomatosis with polyangiitis;System Organ Class: 10021428 - Immune system disorders;Therapeutic area: Diseases [C] - Immune System Diseases [C20] Relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis(EGPA) receiving standard of ca ... | Product Name: Depemokimab Product Code: GSK3511294 INN or Proposed INN: Depemokimab Trade Name: Nucala Product Name: Mepolizumab INN or Proposed INN: Mepolizumab Other descriptive name: Anti-interleukin 5 (IL-5) humanized monoclonal Product Name: Depemokimab Product Code: GSK3511294 INN or Proposed INN: Depemokimab Trade Name: Nucala P ... | GlaxoSmithKline Research & Development Limited | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 192 | Phase 3 | United States;Czechia;Finland;Spain;Austria;Russian Federation;Israel;United Kingdom;Italy;France;Hungary;Canada;Argentina;Belgium;Poland;Brazil;Australia;Germany;Netherlands;China;Japan;Sweden;Korea, Republic of United States;Czechia;Finland;Spain;Austria;Russian Federation;Israel;United Kingdom;Italy;France;Hu ... | ||
| 6 | JPRN-jRCT2031220070 | 01/07/2022 | 19/05/2022 | Efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) Efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory ... | A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) receiving standard of care (SoC) therapy - OCEAN A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority stu ... | Eosinophilic granulomatosis with polyangiitis for which Standard of care is insufficient. | depemokimab Arm: 200 mg depemokimab administered as 2x100 mg SC injections every 26 weeks and mepolizumab administered as placebo SC injections every 4 weeks. mepolizumab Arm: 300 mg mepolizumab administered as 3x100 mg SC injections every 4 weeks and depemokimab administered as placebo SC injections every 26 weeks depemokimab Arm: 200 mg depemokimab administered as 2x100 mg SC injections every 26 weeks and mepoli ... | Fujii Katsuya | NULL | Recruiting | >= 18age old | Not applicable | Both | 9 | Phase 3 | Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Finland;France;Germany;Hungary;Israel;Italy;Mexico;Netherlands;Poland;Portugal;South Korea;Spain;Sweden;United kingdom;USA;Japan Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Finland;France;Germany;Hungar ... |
| 7 | NCT05353179 (ClinicalTrials.gov) | June 2022 | 11/4/2022 | Study on Pharmacokinetics of Meperizumab Injection and NUCALA® in Healthy Male Volunteers | Phase I, Single-center, Randomized, Double-blind, Single-dose, Parallel Comparison of Pharmacokinetic and Safety Similarities Between Meperizumab Injection and NUCALA® in Healthy Male Volunteers Phase I, Single-center, Randomized, Double-blind, Single-dose, Parallel Comparison of Pharmacokineti ... | Granulomatosis With Polyangiitis;Hemophagocytic Syndrome | Drug: Meperizumab injection;Drug: NUCALA® | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | NULL | Not yet recruiting | 18 Years | 55 Years | Male | 88 | Early Phase 1 | China |
| 8 | EUCTR2021-005726-15-ES (EUCTR) | 17/05/2022 | 04/03/2022 | A study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) A study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults wi ... | A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) receiving standard of care (SoC) therapy - OCEAN A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority stu ... | Relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) receiving standard of care (SoC) therapy MedDRA version: 20.0;Level: PT;Classification code 10078117;Term: Eosinophilic granulomatosis with polyangiitis;System Organ Class: 10021428 - Immune system disorders;Therapeutic area: Diseases [C] - Immune System Diseases [C20] Relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis(EGPA) receiving standard of ca ... | Product Name: Depemokimab Product Code: GSK3511294 INN or Proposed INN: Depemokimab Trade Name: Nucala Product Name: Mepolizumab INN or Proposed INN: Mepolizumab Other descriptive name: Anti-interleukin 5 (IL-5) humanized monoclonal Product Name: Depemokimab Product Code: GSK3511294 INN or Proposed INN: Depemokimab Trade Name: Nucala P ... | GlaxoSmithKline Research & Development Limited | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 192 | Phase 3 | United States;Czechia;Finland;Spain;Austria;Israel;Russian Federation;United Kingdom;Italy;France;Canada;Argentina;Brazil;Belgium;Australia;Netherlands;Germany;China;Japan;Sweden;Korea, Republic of United States;Czechia;Finland;Spain;Austria;Israel;Russian Federation;United Kingdom;Italy;France;Ca ... | ||
| 9 | EUCTR2021-000679-35-FR (EUCTR) | 07/09/2021 | 25/06/2021 | SATELITE Salvage Therapy for Patients with Inadequate Response to Standard of Care Therapy in Granulomatosis with Polyangiitis” SATELITE Salvage Therapy for Patients with Inadequate Response to Standard of Care Therapy in Granul ... | SATELITE Salvage Therapy for Patients with Inadequate Response to Standard of Care Therapy in Granulomatosis with Polyangiitis” - SATELITE SATELITE Salvage Therapy for Patients with Inadequate Response to Standard of Care Therapy in Granul ... | Granulomatosis with Polyangiitis;Therapeutic area: Diseases [C] - Blood and lymphatic diseases [C15] Granulomatosis with Polyangiitis;Therapeutic area: Diseases [C] - Blood and lymphatic diseases [C15] ... | Trade Name: Rituximab INN or Proposed INN: RITUXIMAB Trade Name: ROACTEMRA INN or Proposed INN: TOCILIZUMAB Trade Name: ORENCIA INN or Proposed INN: ABATACEPT Trade Name: Methotrexate Other descriptive name: METHOTREXATE Trade Name: Mycophénolate mofétil Other descriptive name: MYCOPHENOLATE MOFETIL Trade Name: Azathioprine Other descriptive name: AZATHIOPRINE Trade Name: Rituximab INN or Proposed INN: RITUXIMAB Trade Name: ROACTEMRA INN or Proposed INN: TOCILIZ ... | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 42 | Phase 2 | France | ||
| 10 | NCT04944524 (ClinicalTrials.gov) | July 1, 2021 | 22/6/2021 | Comparison of Tofacitinib and Methotrexate in the Maintained Treatment of GPA | Randomized Trial of Tofacitinib Versus Methotrexate for Maintenance Therapy in Granulomatosis With Polyangiitis Randomized Trial of Tofacitinib Versus Methotrexate for Maintenance Therapy in Granulomatosis With P ... | Granulomatosis With Polyangiitis | Drug: Tofacitinib;Drug: Methotrexate | Shanghai Zhongshan Hospital | NULL | Recruiting | 18 Years | 75 Years | All | 66 | Phase 4 | China |