46. 悪性関節リウマチ Malignant rheumatoid arthritis Clinical trials / Disease details


臨床試験数 : 4,356 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

  
1313 trials found
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1NCT05756179
(ClinicalTrials.gov)
July 202321/2/2023Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid ArthritisClinical Study Evaluating the Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Diosmin and Hesperidin CombinationAlexandria UniversityNULLNot yet recruiting19 Years65 YearsAll80Phase 3NULL
2NCT05306353
(ClinicalTrials.gov)
May 15, 202323/3/2022CD40L Antagonism in Rheumatoid Arthritis (RA)Combining a CD40L-Binding Protein (VIB4920) With a TNF-alpha Inhibitor for the Treatment of Inadequately Controlled Rheumatoid Arthritis (ITN092AI)Rheumatoid ArthritisDrug: Placebo for VIB4920;Drug: VIB4920 with TNFi;Drug: VIB4920 without TNFiNational Institute of Allergy and Infectious Diseases (NIAID)Immune Tolerance Network (ITN)Not yet recruiting18 Years70 YearsAll104Phase 2United States
3NCT04585711
(ClinicalTrials.gov)
May 20237/10/2020Pharmacokinetics and Pharmacodynamics of Biologic Drugs in Obese Patients With ArthritisPharmacokinetics and Pharmacodynamics of Biologic Drugs in Obese Patients With ArthritisJuvenile Idiopathic Arthritis;Rheumatoid Arthritis;ObesityDrug: Etanercept Optimal dosingDuke UniversityNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Not yet recruiting2 Years65 YearsAll30Phase 1United States
4NCT05622175
(ClinicalTrials.gov)
March 31, 20233/11/2022Safety and Preliminary Signs of Efficacy of F8IL10 for Intra-articular TreatmentA Dose-finding Phase I Study of F8IL10 Intra-articular Treatment in Rheumatoid ArthritisRheumatoid ArthritisDrug: F8IL10Philogen S.p.A.NULLNot yet recruiting18 Years80 YearsAll32Phase 1NULL
5NCT05540938
(ClinicalTrials.gov)
February 15, 202310/9/2022Post-marketing Re-evaluation of WangBi Granules for Rheumatoid ArthritisReevaluation of Original Research Results of Integrated Traditional Chinese and Western Medicine and Transformation of Hospital Preparations: Post-marketing Re-evaluation of WangBi Granules for Rheumatoid ArthritisRheumatoid ArthritisDrug: Wangbi granules;Drug: Wangbi granules simulantChina-Japan Friendship HospitalPeking Union Medical College Hospital;The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine;The 980th Hospital of PLA Joint Logistics Support Force;The Second Affiliated Hospital of Zhejiang Chinese Medical University;Southwest Hospital, ChinaNot yet recruiting18 Years75 YearsAll340Phase 4NULL
6NCT05305066
(ClinicalTrials.gov)
February 1, 202326/2/2022Stand UP to Rheumatoid Arthritis (SUPRA)Innovative Trial Designs, Multi-omics and Advanced Computational Prediction to Transform Clinical Care in RARheumatoid ArthritisDrug: TNFi;Drug: Anti-IL6;Drug: JAKiMarie Hudson, MDMcGill University Health Centre/Research Institute of the McGill University Health Centre;Montreal General Hospital;Lady Davis InstituteRecruiting18 YearsN/AAll75N/ACanada
7NCT03938701
(ClinicalTrials.gov)
January 202325/2/2019Fluorescence Imaging of Disease Activity in IBD and Rheumatoid Arthritis Using OTL38Fluorescence Imaging for the Evaluation of Disease Activity in IBD and Rheumatoid Arthritis Using the Fluorescent Tracer OTL38 Targeting the Folate ß Receptor: a Single-center Pilot StudyIBD;Rheumatoid ArthritisDrug: OTL38;Device: Fluorescence ImagingUniversity Medical Center GroningenGlaxoSmithKline;On Target Laboratories, LLC;Amsterdam UMC, location VUmcNot yet recruiting18 YearsN/AAll30Phase 1Netherlands
8NCT05545020
(ClinicalTrials.gov)
December 25, 20229/9/2022Trivalent Chromium Treatment for Rheumatoid ArthritisTrivalent Chromium as a Treatment for Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Trivalent chromium versus synthetic and/ or biological DMARDsAlexandria UniversityNULLRecruiting18 Years80 YearsAll60Phase 2/Phase 3Egypt
9NCT05480878
(ClinicalTrials.gov)
December 2, 202223/7/2022Role of Nitazoxanide and Escitalopram in Patients With Rheumatoid ArthritisClinical Study Evaluating the Efficacy of Nitazoxanide and Escitalopram as Adjuvant Therapies in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Placebo;Drug: Nitazoxanide 500Mg Oral Tablet;Drug: Escitalopram 10mgTanta UniversityNULLNot yet recruiting18 Years75 YearsAll90Phase 3NULL
10NCT05604885
(ClinicalTrials.gov)
November 30, 202231/10/2022A Dose-range Study of the Safety and Efficacy of Treatment in Adult Rheumatoid Arthritis Patients With an Inadequate Response to MethotrexateA Two-part, Randomized, Double-blind, Multi-center, Placebo-controlled Study of the Dose-range, Safety and Efficacy of 4 and 12 Weeks of Treatment With AP1189 in Adult Rheumatoid Arthritis (RA) Patients With an Inadequate Response to Methotrexate (MTX) Alone - (RESOLVE)Rheumatoid ArthritisDrug: AP1189, 60 mg;Drug: AP1189, 80 mg;Drug: AP1189, 100 mg;Drug: PlaceboSynAct Pharma ApsNBCD A/SRecruiting18 Years85 YearsAll420Phase 2Moldova, Republic of
11NCT05428488
(ClinicalTrials.gov)
November 28, 202216/6/2022Efficacy of a Sequential Treatment Strategy in Rheumatoid ArthritisEfficacy of a Sequential Treatment Strategy in Rheumatoid Arthritis. A Randomized Controlled Trial With an Independent Efficacy Assessor.Rheumatoid ArthritisDrug: Abatacept (M3-M12);Drug: TNF Inhibitor (M3-M12);Drug: TNF Inhibitor (M0-M3)University Hospital, MontpellierNULLRecruiting18 Years85 YearsAll220Phase 3France
12NCT05375942
(ClinicalTrials.gov)
November 11, 202211/5/2022This is a Retrospective Observational Study Looking at the Characteristics and Outcomes of Participants Taking Inflectra Using the CorEvitas Rheumatoid Arthritis RegistryCharacteristics and 6-month Outcomes Among Real-World Rheumatoid Arthritis Patients Initiating InflectraArthritis, RheumatoidDrug: InflectraPfizerNULLCompleted18 YearsN/AAll255United States
13NCT05594680
(ClinicalTrials.gov)
November 1, 202218/10/2022Cilostazol and Methotrexate in Rheumatoid ArthritisThe Phosphodiesterase 3 Inhibitor Cilostazol as Adjunct to Methotrexate in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Cilostazol;Drug: Methotrexate;Drug: PlaceboTanta UniversityNULLNot yet recruiting18 Years60 YearsAll70Phase 3NULL
14NCT05671497
(ClinicalTrials.gov)
November 1, 202214/12/2022The Effect of Cilostazol on Rheumatoid Arthritis PatientsEvaluation of the Effect of Cilostazol on the Clinical Outcomes of Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Cilostazol 100 MG;Drug: conventional synthetic antirheumatic drugsAin Shams UniversityMisr International University;Al-Azhar UniversityRecruiting19 YearsN/AAll70Phase 2/Phase 3Egypt
15NCT05533372
(ClinicalTrials.gov)
October 10, 20225/9/2022MAD Study of IA-14069Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IA-14069 in Healthy Subjects, With an Extension to Explore Any Drug-Drug Interaction Potential With Methotrexate (Part 1), and in Patients With Rheumatoid Arthritis, With Preliminary Assessment of Efficacy in Patients (Part 2)Healthy;Rheumatoid ArthritisDrug: IA-14069;Drug: Placebo;Drug: MethotrexateILAb Co., Ltd.NULLRecruiting18 Years70 YearsAll75Phase 1United States
16NCT05451615
(ClinicalTrials.gov)
September 30, 202217/6/2022Efficacy and Safety of Abatacept Combined With JAK Inhibitor for Refractory Rheumatoid ArthritisClinical Efficacy and Safety of Real-world Patients With Refractory Rheumatoid Arthritis (D2TRA) Receiving Abatacept in Combination With a Janus Kinase (JAK) InhibitorAbatacept;Treatment Compliance;Rheumatoid ArthritisDrug: Janus Kinase Inhibitor;Drug: AbataceptZhejiang Provincial People's HospitalNULLRecruitingN/AN/AAll90Phase 3China
17NCT05516979
(ClinicalTrials.gov)
September 26, 202224/8/2022A Safety & Efficacy Study of Treatment With AP1189 in Rheumatoid Arthritis Patients naïve to DMARD TreatmentA Double-blind, Multi-center, Randomized, Placebo-controlled Study of the Safety and Efficacy of 12 Weeks Extended Treatment With AP1189 in Early Rheumatoid Arthritis (RA) Patients naïve to DMARD TreatmentRheumatoid ArthritisDrug: 100 mg AP1189;Drug: PlaceboSynAct Pharma ApsNBCD A/SRecruiting18 Years85 YearsAll120Phase 2Moldova, Republic of
18NCT05660655
(ClinicalTrials.gov)
September 1, 202213/12/2022Efficacy and Safety of Baricitinib for the Treatment of Moderate to Severe Rheumatoid ArthritisEfficacy and Safety of Baricitinib in Different Doses for the Treatment of Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: Baricitinib 4 MG;Drug: Baricitinib 2 MGBangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshNULLRecruiting18 YearsN/AAll94Phase 4Bangladesh
19NCT05516758
(ClinicalTrials.gov)
August 31, 202224/8/2022A Study of Peresolimab (LY3462817) in Participants With Moderately-to-Severely Active Rheumatoid ArthritisA Phase 2b, Double-Blind, Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants With Moderately-to-Severely Active Rheumatoid ArthritisRheumatoid Arthritis;Arthritis;Joint Diseases;Musculoskeletal Diseases;Rheumatic Diseases;Connective Tissue Diseases;Autoimmune Diseases;Immune System DiseasesDrug: Peresolimab;Drug: PlaceboEli Lilly and CompanyNULLRecruiting18 YearsN/AAll420Phase 2United States;Argentina;Canada;China;Greece;Hungary;Italy;Japan;Mexico;Poland;Puerto Rico;Spain
20NCT05460832
(ClinicalTrials.gov)
August 29, 202212/7/2022Phase 2b Study of MBS2320 in Participants With Methotrexate-Refractory RAA Randomised, Double-Blind, Placebo-Controlled, Dose-Ranging Phase 2b Study to Investigate the Efficacy & Safety of MBS2320 in Participants With Moderate to Severe Active Rheumatoid Arthritis With Inadequate Response to Methotrexate AloneRheumatoid ArthritisDrug: MBS2320 5 mg;Drug: MBS2320 20 mg;Drug: MBS2320 40 mg;Drug: PlaceboModern Biosciences LtdNULLRecruiting18 Years75 YearsAll224Phase 2Bosnia and Herzegovina;Bulgaria;Chile;Czechia;Guatemala;Mexico;Poland;Serbia
21NCT05576597
(ClinicalTrials.gov)
August 23, 20227/10/2022Effect of Butyrate Supplement on Rheumatoid ArthritisA Pilot Study to Evaluate Efficacy and Safety of Butyrate Supplement in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: Sodium ButyratePeking University People's HospitalNULLRecruiting18 YearsN/AAll30Phase 2China
22NCT05437419
(ClinicalTrials.gov)
August 10, 202223/6/2022A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral Doses of TCK-276 in Patients With Rheumatoid ArthritisA Phase 1, Randomized, Placebo-controlled, Double-blind, Multiple Ascending Dose Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral Doses of TCK-276 in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: TCK-276;Drug: TCK-276 PlaceboTeijin America, Inc.ParexelRecruiting18 Years64 YearsAll32Phase 1United States
23NCT05274243
(ClinicalTrials.gov)
August 9, 20221/3/20222-HOBA Phase 2 Clinical Trial in Rheumatoid Arthritis2-HOBA Phase 2 Clinical Trial in Rheumatoid ArthritisRheumatoid ArthritisDrug: 2-HOBA;Other: PlaceboVanderbilt University Medical CenterNULLRecruiting18 YearsN/AAll32Phase 2United States
24NCT05392127
(ClinicalTrials.gov)
July 15, 202223/5/2022A Pharmacokinetic Study to Evaluate the Drug Interaction Between SHR0302 and CYP Substrates in Healthy VolunteersA Single-center, Open-label, Single-arm, Fixed-sequence Study to Evaluate the Pharmacokinetic Effects of SHR0302 Tablets on Substrates of CYP3A4, CYP2C8, CYP2C9, CYP2C19 in Healthy VolunteersRheumatoid ArthritisDrug: SHR0302 Tablets;Drug: Midazolam Maleate Tablets;Drug: Warfarin Sodium Tablets;Drug: Omeprazole Enteric Capsules;Drug: Vitamin K1 Tablets;Drug: Repaglinide TabletsJiangsu HengRui Medicine Co., Ltd.NULLCompleted18 Years45 YearsMale24Phase 1China
25NCT05447520
(ClinicalTrials.gov)
July 15, 20221/7/2022Montelukast Use in Rheumatoid ArthritisClinical Study Evaluating the Efficacy and Safety of Adjunctive Use of Montelukast in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Montelukast;Drug: Placebo;Drug: Conventional DMARDsNoha MansourNULLRecruiting18 Years80 YearsAll50Phase 2Egypt
26NCT05165771
(ClinicalTrials.gov)
July 20228/12/2021Study to Evaluate Safety, Tolerability, and Efficacy of GS-5718 in Participants With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-modifying Antirheumatic Drug(s) (bDMARDs) TreatmentA Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 2 Proof-of-Concept Study to Evaluate Safety, Tolerability, and Efficacy of GS-5718 on Background Therapy With Conventional Synthetic Disease-modifying Antirheumatic Drug(s) (csDMARDs) in Participants With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic DMARD(s) TreatmentRheumatoid ArthritisDrug: GS-5718;Drug: Placebo to match GS-5718;Drug: Tofacitinib 5 mg;Drug: Placebo to match TofacitinibGilead SciencesNULLWithdrawn18 Years75 YearsAll0Phase 2NULL
27NCT05379322
(ClinicalTrials.gov)
July 202212/5/2022The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis PatientsThe Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Anti-TNF;Drug: JAK inhibitorAbu Dhabi Stem Cells CenterNULLWithdrawn18 YearsN/AAll0Phase 3United Arab Emirates
28NCT05404724
(ClinicalTrials.gov)
June 25, 202231/5/2022Study on the Pharmacokinetic Effect of Itraconazole on SHR0302 Tablets in Healthy SubjectsStudy on the Pharmacokinetic Effects of Single-centered, Open, Single-arm, Fixed-sequence Itraconazole on SHR0302 Tablets in Healthy SubjectsRheumatoid ArthritisDrug: itraconazole? SHR0302 tabletsJiangsu HengRui Medicine Co., Ltd.NULLCompleted18 Years45 YearsMale14Phase 1China
29NCT05092984
(ClinicalTrials.gov)
June 22, 202228/9/2021Evaluation of Spironolactone Efficacy in Patient With Rheumatoid Arthritis (RA)Evaluation of Spironolactone Efficacy in Patient With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Spironolactone;Drug: PlaceboUniversity Hospital, Strasbourg, FranceNULLRecruiting18 YearsN/AAll154Phase 3France
30NCT05363891
(ClinicalTrials.gov)
June 15, 20222/5/2022Natrunix or Placebo in Combination With Methotrexate in Rheumatoid ArthritisPhase II, Double-blind, Placebo-Controlled, Randomized Trial Examining Natrunix in Combination With Methotrexate (+Folate) for the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: Natrunix;Drug: PlaceboXBiotech, Inc.NULLNot yet recruiting18 YearsN/AAll150Phase 2NULL
31NCT05363917
(ClinicalTrials.gov)
June 15, 20222/5/2022Natrunix Versus Methotrexate in Rheumatoid ArthritisPhase II Double-Blinded, Placebo-Controlled Randomized Study Examining the Safety and Efficacy of Natrunix Versus Methotrexate (+Folate) for the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: Natrunix with MTX placebo (+folate);Drug: Natrunix placebo with MTX (+folate)XBiotech, Inc.NULLNot yet recruiting18 YearsN/AAll150Phase 2NULL
32NCT05427942
(ClinicalTrials.gov)
June 3, 202217/6/2022Yuflyma® (Adalimumab), Patient Experience After SwitchingYUflyma® (Adalimumab), Patient Experience After Switching to adaliMumab biosimilAr High concenTration, Low Volume (40mg/0.4mL) (Yuflyma®) by Taking Patient pERception of Treatment Into Account: The YU-MATTER StudyRheumatoid Arthritis;Ankylosing Spondylarthritis;Axial Spondyloarthritis Without Radiographic Evidence of Ankylosing Spondylitis;Psoriatic Arthritis;Crohn Disease;Ulcerative ColitisDrug: AdalimumabCelltrion HealthCare FranceNULLRecruiting18 YearsN/AAll300France
33NCT05264025
(ClinicalTrials.gov)
June 1, 202210/1/2022Fexofenadine in Patients With Active Rheumatoid ArthritisFexofenadine as Adjunct to Standard Rheumatoid Therapy in Patients With Active RheumatoidRheumatoid ArthritisDrug: Fexofenadine;Drug: PlaceboOctober 6 UniversityNULLRecruiting18 Years60 YearsAll80Phase 1/Phase 2Egypt
34NCT05267431
(ClinicalTrials.gov)
June 202214/2/2022Outcomes of Biological Therapy on Rheumatoid ArthritisOutcomes of Different Biological Therapy on Rheumatoid ArthritisRheumatoid ArthritisDrug: Biological DrugSohag UniversityNULLNot yet recruiting18 YearsN/AAll200Egypt
35NCT05606107
(ClinicalTrials.gov)
May 20, 20221/11/2022To Compare the Efficacy and Safety of Low-dose Glucocorticoids and Tofacitinib in Alleviating Moderate to High Disease Activity Rheumatoid Arthritis for 24 WeeksTo Compare the Efficacy and Safety of Low-dose Glucocorticoids and Tofacitinib in Alleviating Moderate to High Disease Activity Rheumatoid Arthritis for 24 WeeksRheumatoid ArthritisDrug: Tofacitinib;Drug: GlucocorticoidSecond Affiliated Hospital, School of Medicine, Zhejiang UniversityJiaxing Hospital of T.C.M;Jinhua Municipal Central Hospital;SAHZU.CHANGXING CAMPUS;Zhuji People's hospital;Shaoxing People's HospitalRecruiting18 Years70 YearsAll230Phase 4China
36NCT04269993
(ClinicalTrials.gov)
May 18, 202212/2/2020Impact of Cannabis on Pain and Inflammation Among Patients With Rheumatoid or Psoriatic ArthritisImpact of Acute Cannabis Administration on Pain Symptomology and Inflammatory Markers Among Patients With Rheumatoid or Psoriatic ArthritisRheumatoid Arthritis;Psoriatic ArthritisDrug: Cannabis: placebo and medium THC/medium CBDBrown UniversityNULLRecruiting18 Years65 YearsAll76Phase 2United States
37NCT05323591
(ClinicalTrials.gov)
May 3, 20225/4/2022Prospective Observational Study of Filgotinib in Female Participants With Rheumatoid Arthritis in FranceA Prospective, Non-interventional Study in Female Patients With Moderate to Severe Active Rheumatoid Arthritis in France Receiving Filgotinib for 2 YearsRheumatoid ArthritisDrug: FilgotinibGalapagos NVNULLRecruiting18 YearsN/AFemale150France
38NCT05374785
(ClinicalTrials.gov)
May 1, 20224/5/2022Efficacy and Safety Study Comparing CPL409116 to Placebo in Participants With Active Rheumatoid ArthritisA 12-week, Phase II, Multicentre, Randomised, Double Blind, Efficacy and Safety Study Comparing CPL409116 to Placebo, in Combination With Methotrexate in Participants With Active Rheumatoid Arthritis Who Have an Inadequate Response to MTXRheumatoid ArthritisDrug: CPL409116;Other: PlaceboCelon Pharma SANational Center for Research and Development, PolandRecruiting18 Years75 YearsAll100Phase 2Poland
39NCT05380934
(ClinicalTrials.gov)
May 202216/5/2022A Clinical Trial of Safety and Tolerance of TQH3821 Tablets in Adult Healthy SubjectsA Randomized, Double-blind, Placebo-controlled Phase I Clinical Trial of TQH3821 in Adult Healthy SubjectsRheumatoid ArthritisDrug: TQH3821 tablets;Drug: TQH3821 tablets (Placebo);Drug: Methotrexate tabletsChia Tai Tianqing Pharmaceutical Group Co., Ltd.NULLRecruiting18 Years55 YearsAll62Phase 1China
40NCT05246293
(ClinicalTrials.gov)
April 1, 202217/1/2022Tofacitinib in the Treatment of Rheumatoid Arthritis-related Interstitial Lung Disease.Safety and Tolerability of Tofacitinib in the Treatment of Rheumatoid Arthritis-related Interstitial Lung Disease (RAILDTo Trial).Rheumatoid Arthritis;Interstitial Lung DiseaseDrug: TofacitinibNational Institute of Respiratory Diseases, MexicoNULLRecruiting18 YearsN/AAll60Phase 2Mexico
41NCT05166304
(ClinicalTrials.gov)
April 20228/12/2021Rebamipide in Patients With Active Rheumatoid ArthritisRebamipide as an Adjunct to Methotrexate in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Rebamipide;Drug: PlaceboOctober 6 UniversityNULLNot yet recruiting18 Years60 YearsAll100Phase 1/Phase 2NULL
42NCT05424393
(ClinicalTrials.gov)
March 4, 202215/6/2022Real-World Study on Long-term Treatment With YISAIPU for Fujian RA PatientsLong-term Real-world Prospectiv Observational Study on Maintenance Treatment With YISAIPU, an Etanercept Biosimilar, for Patients Wih Rheumatoid Arthritis of Fujian Province of ChinaRheumatoid ArthritisDrug: YISAIPU® ( An etanercept biosimilar);Drug: csDMARDsThe First Affiliated Hospital of Xiamen UniversityNULLRecruiting18 Years75 YearsAll500China
43NCT05246280
(ClinicalTrials.gov)
March 2, 202216/12/2021Tc 99m Tilmanocept Imaging for Early Prediction of Anti-TNFa Therapy Response in Moderate to Severe Active RAEvaluation of Tc 99m Tilmanocept Imaging for the Early Prediction of Anti-TNFa Therapy Response in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: TC99m-tilmanoceptNavidea BiopharmaceuticalsNULLRecruiting18 YearsN/AAll523Phase 3United States
44NCT05182203
(ClinicalTrials.gov)
March 1, 202218/12/2021Safety and Retention Rate of the JAK and TNF Inhibitors in Rheumatoid Arthritis: a Real-life ExperienceSafety and Retention Rate of the JAK and TNF Inhibitors in Rheumatoid Arthritis: a Real-life ExperienceRheumatoid Arthritis;Drug UseDrug: biologic/targeted therapyTuen Mun HospitalNULLCompleted18 YearsN/AAll1732China
45NCT05240859
(ClinicalTrials.gov)
February 22, 20226/2/2022Real World Study of a Adalimumab Biosimilar (Geleli) in Rheumatoid ArthritisA Multicenter, Prospective, Observational Real World Study For the Efficacy and Safety of a Adalimumab Biosimilar (Geleli) in Rheumatoid Arthritis.Rheumatoid ArthritisDrug: GeleliPeking University People's HospitalNULLNot yet recruitingN/AN/AAll1600China
46NCT05245448
(ClinicalTrials.gov)
February 22, 202222/1/2022Tetrandrine in the Treatment of Rheumatoid ArthritisComparing the Efficacy of Tetrandrine Combined With Methotrexate and Methotrexate Alone in the Treatment of Rheumatoid arthritis---a Randomized, Double-blinded, Placebo-controlled, Multicenter StudyRheumatoid ArthritisDrug: Tetrandrine;Drug: PlaceboPeking University People's HospitalNULLNot yet recruiting18 Years65 YearsAll240N/AChina
47NCT05133297
(ClinicalTrials.gov)
February 16, 202215/11/2021The Safety and Efficacy of TLL-018 in Active Rheumatoid ArthritisA Phase 2A, Randomized, Double-blind, Double-dummy, Tofacitinib-parallel-group Study to Evaluate the Safety and Efficacy of TLL-018 in Active Rheumatoid Arthritis Who Had an Inadequate Response or Intolerance to Methotrexate.Rheumatoid ArthritisDrug: TLL-018;Drug: TofacitinibHangzhou Highlightll Pharmaceutical Co., LtdNULLRecruiting18 Years75 YearsAll100Phase 2China
48NCT05671627
(ClinicalTrials.gov)
February 2, 202219/9/2022Cortisol Circadian Rhythm in Patients With RAAn Impaired Functional Reserve of Adrenal Cortex May Associate With difficult-to Treat RA: Can a Disturbed Cortisol Circadian Rhythm Serve as a Predictor of Difficult-to-treat RA?Rheumatoid ArthritisDrug: DMARDsNational and Kapodistrian University of AthensNULLRecruiting20 Years80 YearsAll50Greece
49NCT05279417
(ClinicalTrials.gov)
February 2, 202218/2/2022ATI-450 Plus MTX Versus Placebo Plus MTX in Patients With Moderate to Severe Active RAATI-450 Plus MTX Versus Placebo Plus MTX in Patients With Moderate to Severe Active RA Who Have Had an Inadequate Response to MTX AloneRheumatoid ArthritisDrug: ATI-450 50mg oral tablet BID;Drug: Placebo oral tablet;Drug: Methotrexate;Drug: ATI-450 20mg oral tablet BIDAclaris Therapeutics, Inc.NULLRecruiting18 Years75 YearsAll240Phase 2United States;Czechia;Poland
50NCT04876781
(ClinicalTrials.gov)
January 12, 202220/4/2021Korean Post-marketing Surveillance for Xeljanz XRKorean Post-marketing Surveillance for Xeljanz XR (Registered)Active Moderate to Severe Rheumatoid Arthritis;Active Ankylosing SpondylitisDrug: Tofacitinib XRPfizerNULLRecruiting18 YearsN/AAll200Korea, Republic of
51NCT05053165
(ClinicalTrials.gov)
January 4, 202216/9/2021A Study to Assess the Safety and Tolerability of LB-P6 and LB-P8 in Healthy ParticipantsA Phase 1, Randomised, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses of LB-P6 or LB-P8 in Healthy ParticipantsRheumatoid Arthritis;Non-Alcoholic SteatohepatitisDrug: LB-P6;Drug: LB-P8;Drug: PlaceboLISCure BiosciencesNULLCompleted18 Years65 YearsAll31Phase 1Australia
52NCT05090124
(ClinicalTrials.gov)
January 1, 202220/7/2021Experimental Medicine Studies of Brain and Peripheral Immune Mechanisms for Sickness Behaviours in Patients With Rheumatoid ArthritisExperimental Medicine Studies of Brain and Peripheral Immune Mechanisms for Sickness Behaviours in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Adalimumab;Drug: PlaceboNHS Greater Glasgow and ClydeUniversity of GlasgowNot yet recruiting18 Years74 YearsAll50N/ANULL
53NCT05153200
(ClinicalTrials.gov)
January 202229/11/2021Early Changes in Pain, Disease Activity, and Ultrasound Evidence of Inflammatory Synovitis in Patients Receiving JAK-inhibitor vs. TNF-inhibitor Therapy for Active Rheumatoid Arthritis: A Feasibility Study.Early Changes in Pain, Disease Activity, and Ultrasound Evidence of Inflammatory Synovitis in Patients Receiving JAK-inhibitor vs. TNF-inhibitor Therapy for Active Rheumatoid Arthritis: A Feasibility Study.Rheumatoid ArthritisDrug: Upadacitinib;Drug: AdalimumabOttawa Hospital Research InstituteThe Ottawa Hospital;University of OttawaNot yet recruiting18 YearsN/AAll40Phase 4NULL
54NCT05313061
(ClinicalTrials.gov)
December 29, 202128/12/2021MTX Hold During Covid-19 BoosterEffect of One-week Discontinuation of Methotrexate on Immunogenicity of COVID-19 Booster Vaccination in Patients With Rheumatoid Arthritis: A Randomized Pilot StudyRheumatoid ArthritisDrug: MTXSeoul National University HospitalNULLRecruiting19 YearsN/AAll40Phase 3Korea, Republic of
55NCT05626348
(ClinicalTrials.gov)
December 22, 202115/11/2022The Clinical Efficacy of Immunomodulators in RA PatientsThe Clinical Study to Observe the Efficacy and Safety of Immunomodulators in Rheumatoid Arthritis Patients for 6 Months Treatment in ChinaArthritis, RheumatoidDrug: Iguratimod;Drug: Methotrexate;Drug: Adalimumab Injection;Drug: Leflunomide;Drug: HydroxychloroquineQilu Hospital of Shandong UniversityNULLRecruiting18 Years80 YearsAll400Phase 4China
56NCT05198310
(ClinicalTrials.gov)
December 14, 20213/1/2022Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase InhibitorA Phase 2, Multicenter, Randomized, Double-blind, Placebo Controlled Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Subjects With Moderate to Severe Active Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase InhibitorArthritis, RheumatoidDrug: KPL-404;Drug: PlaceboKiniksa Pharmaceuticals, Ltd.NULLRecruiting18 Years80 YearsAll91Phase 2United States;Czechia
57NCT05080218
(ClinicalTrials.gov)
November 15, 20216/10/2021COVID-19 VaccinE Response in Rheumatology PatientsThe SARS-CoV-2 Vaccine Response and Safety in Rheumatology Patients and the Influence of Temporary Interruptions in Immunomodulatory TherapyRheumatoid Arthritis;Psoriatic Arthritis;SpondylarthritisDrug: Upadacitinib;Drug: Abatacept;Drug: Secukinumab;Drug: Tofacitinib;Drug: TNF Inhibitor;Drug: Canakinumab Injection;Drug: Baricitinib;Drug: IxekizumabJeffrey CurtisUniversity of Alabama at Birmingham;University of Nebraska;University of Pennsylvania;AbbVie;Bristol-Myers Squibb;Novartis;Eli Lilly and Company;PfizerRecruiting18 Years85 YearsAll1000Phase 4United States
58NCT04834557
(ClinicalTrials.gov)
November 1, 20212/4/2021Evaluating the Effect of Digoxin and Ursodeoxycholic Acid in Patients With Rheumatoid ArthritisEvaluating the Effect of Digoxin and Ursodeoxycholic Acid in Patients With Rheumatoid Arthritis in EgyptRheumatoid ArthritisDrug: Placebo;Drug: Digoxin 0.25 mg;Drug: Ursodeoxycholic acid (UDCA) 500 mgTanta UniversityNULLRecruiting18 Years80 YearsAll90Phase 2Egypt
59NCT04985812
(ClinicalTrials.gov)
October 18, 20216/7/2021A Study of JNJ-67484703 in Participants With Active Rheumatoid ArthritisA Multicenter, Double-blind, Placebo-controlled, Randomized, Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of JNJ-67484703 in Participants With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: JNJ-67484703;Drug: PlaceboJanssen Research & Development, LLCNULLRecruiting18 Years65 YearsAll47Phase 1United States;Georgia;Hungary;Moldova, Republic of;Spain;Ukraine
60NCT04911127
(ClinicalTrials.gov)
October 5, 202114/5/2021Therapeutic Response of Cannabidiol in Rheumatoid ArthritisRandomized, Double Blind, Placebo-Controlled Trial to Evaluate the Safety and Tolerability of Cannabidiol (CBD) in Moderate to Severe Rheumatoid ArthritisRheumatoid Arthritis;CannabisDrug: 200mg Cannabidiol by capsules twice daily;Drug: 400mg Cannabidiol by capsules twice daily;Drug: Placebo capsulesUniversity of California, Los AngelesNULLRecruiting18 YearsN/AAll60Phase 1/Phase 2United States
61NCT05069714
(ClinicalTrials.gov)
October 1, 202126/9/2021One or Two Week Methotrexate Discontinuation on Efficacy of Influenza Vaccination in Rheumatoid Arthritis.Effect of One-week vs Two-week Discontinuation of Methotrexate on Efficacy of Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis: A Randomized Clinical TrialRheumatoid Arthritis;Autoimmune Diseases;Influenza;Vaccine ReactionDrug: MTX-holdSeoul National University HospitalNULLCompleted19 YearsN/AAll184Phase 3Korea, Republic of
62NCT04692493
(ClinicalTrials.gov)
September 22, 202115/12/2020RA-PRO PRAGMATIC TRIALA Real-World Comparative Effectiveness Trial of Treatment Strategies in Patients With Rheumatoid Arthritis: The RA-PRO Pragmatic Trial (RA-PROPR)Rheumatoid ArthritisDrug: targeted synthetic DMARD class;Drug: non-TNFi-biologic classUniversity of Alabama at BirminghamPatient-Centered Outcomes Research InstituteRecruiting18 YearsN/AAll924Phase 3United States
63NCT04909801
(ClinicalTrials.gov)
September 15, 202128/5/2021A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to MethotrexateA Randomized, Head-to-head, Single-blind Study to Compare the Response to Treatment With Subcutaneous Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive Rheumatoid Arthritis Who Have Shared Epitope HLA Class II Risk Alleles and Have an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Abatacept;Drug: Adalimumab;Drug: MethotrexateBristol-Myers SquibbNULLActive, not recruiting18 YearsN/AAll300Phase 3Taiwan;United Kingdom;United States;Argentina;Australia;Czechia;France;Germany;Italy;Japan;Mexico;Poland;Spain;Switzerland
64NCT04078191
(ClinicalTrials.gov)
September 14, 202121/8/2019Comparison of Tc 99m Tilmanocept Quantitative Imaging With Immunohistochemical (IHC) Analysis of CD206 Expression in Synovial Tissue of Subjects With Rheumatoid Arthritis (RA)A Comparison of Tc 99m Tilmanocept Quantitative Imaging With Immunohistochemical (IHC) Analysis of CD206 Expression in Synovial Tissue From Subjects Clinically Diagnosed With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Tc 99m tilmanoceptNavidea BiopharmaceuticalsNULLRecruiting18 YearsN/AAll24Phase 2United States;United Kingdom
65NCT05251870
(ClinicalTrials.gov)
August 17, 202121/12/2021Tolerogenic Dendritic Cell Therapy for Rheumatoid ArthritisTolerogenic Dendritic Cell Therapy for Rheumatoid Arthritis: the TOLERANT TrialRheumatoid ArthritisDrug: autologous mature tolerogenic monocyte-derived Dendritic Cells loaded with the B29 peptide of HSP70UMC UtrechtRadboud University Medical Center;Utrecht University;Trajectum Pharma B.V.;Dutch Arthritis Association;ZonMw: The Netherlands Organisation for Health Research and Development;Health HollandRecruiting18 YearsN/AAll18Phase 1/Phase 2Netherlands
66NCT05651373
(ClinicalTrials.gov)
July 30, 202115/11/2022The Clinical Features and Pregnancy Outcomes of RA PatientsThe Clinical Features and Pregnancy Outcomes of Patients With Rheumatoid Arthritis :a Prospective Cohort StudyRheumatoid Arthritis;Pregnancy RelatedDrug: Prednisone;Drug: Hydroxychloroquine;Drug: CertolizumabPegol injectionQilu Hospital of Shandong UniversityNULLRecruiting20 Years45 YearsFemale100China
67NCT04870203
(ClinicalTrials.gov)
July 15, 202126/4/2021Combination of Baricitinib and Adalimumab in Rheumatoid ArthritisCombination of Baricitinib and Adalimumab vs. Baricitinib in Patients With Rheumatoid Arthritis: a Randomized Placebo-controlled Phase III TrialRheumatoid ArthritisDrug: baricitinib treatment;Drug: adalimumab;Drug: PlaceboUniversity Hospital, BordeauxEli Lilly and Company;Biogen;Ministry for Health and Solidarity, FranceRecruiting18 Years75 YearsAll178Phase 3France;Monaco
68NCT05117593
(ClinicalTrials.gov)
June 28, 202123/9/2021Investigate the Safety, Tolerability and Pharmacokinetics of FBL-MTXPhase 1 Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single-Ascending Doses of FBL-MTX in Healthy SubjectsRheumatoid ArthritisDrug: FBL-MTX;Drug: PlaceboSOLFARCOS - Pharmaceutical and Cosmetic Solutions LtdNULLCompleted18 Years55 YearsAll32Phase 1Portugal
69NCT04909931
(ClinicalTrials.gov)
June 15, 202111/5/2021Vitamin D Supplementation on Outcome and Disease Activity.Vitamin D Supplementation on Outcome and Disease Activity in Rheumatoid Arthritis Patients at Rajavithi Hospital : A Randomized Clinical TrialRheumatoid Arthritis, Vitamin D , Disease Activity, DAS28ESRDrug: Vitamin D 2;Drug: PlaceboRajavithi HospitalNULLRecruiting18 YearsN/AAll60N/AThailand
70NCT04888585
(ClinicalTrials.gov)
June 2, 202113/5/2021Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABBV-154 in Subjects With Moderately to Severely Active Rheumatoid Arthritis With Inadequate Response to Biologic and/or Targeted Synthetic Disease-Modifying Anti-Rheumatic Drugs (b/tsDMARDs)Rheumatoid Arthritis (RA)Drug: ABBV-154;Drug: PlaceboAbbVieNULLActive, not recruiting18 Years75 YearsAll473Phase 2United States;Australia;Canada;Czechia;Germany;Greece;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Puerto Rico;Russian Federation;Slovakia;Spain;Taiwan;Turkey;Ukraine;France;United Kingdom
71NCT04885751
(ClinicalTrials.gov)
June 1, 202126/4/2021Compare the Effect of Eupatilin and Rebamipide on the Prevention of GastroenteropathyCompare the Effect of Eupatilin and Rebamipide on the Prevention of Gastroenteropathy in Patients With NSAIDs and Low Dose Steroid: A Single-center, Randomized, Open Labeled, Pilot StudyRheumatoid Arthritis;Osteoarthritis;Ankylosing Spondylitis;Other Musculoskeletal Disorder;Gastric Ulcer;Enteritis;NSAID-Associated Gastropathy;NSAID (Non-Steroidal Anti-Inflammatory Drug) Induced EnteropathyDrug: Eupatilin;Drug: RebamipideSeoul National University Boramae HospitalDong-A ST Co., Ltd.Not yet recruiting19 Years70 YearsAll50Phase 4NULL
72NCT04927000
(ClinicalTrials.gov)
May 31, 202131/5/2021The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid ArthritisThe Role of Tofacitinib in Steroid Withdrawal in Rheumatoid ArthritisRheumatoid ArthritisDrug: TofacitinibSecond Affiliated Hospital, School of Medicine, Zhejiang UniversityNULLRecruiting30 Years65 YearsFemale170Phase 4China
73NCT04885829
(ClinicalTrials.gov)
May 31, 20213/5/2021Comparative Study of 3 Tocilizumab Products in Normal Healthy VolunteeersA Single Dose, Double-Blind, Two-Period, Crossover, Comparative Pharmacokinetic Study of Three Tocilizumab Products Administered by the Subcutaneous Route to Normal Healthy VolunteersRheumatoid Arthritis;Giant Cell ArteritisDrug: Tocilizumab Prefilled SyringeSyneos HealthDr. Reddy's Laboratories LimitedActive, not recruiting18 Years50 YearsAll300Phase 1Australia;India;New Zealand
74NCT04842981
(ClinicalTrials.gov)
May 25, 202123/3/2021Interleukin-6 Inhibitors and Drug-drug Interactions in Patients With Rheumatoid ArthritisInterleukin-6 Inhibitors and Drug-drug Interactions in Patients With Rheumatoid ArthritisArthritis, Rheumatoid;InteractionDrug: Tocilizumab;Drug: SarilumabUniversity of Southern DenmarkOdense University Hospital;Hospital of South West Jutland;King Christian X´Hospital for Rheumatic Diseases;Sygehus Lillebaelt;Odense Patient Data Explorative NetworkTerminated18 Years75 YearsAll3Phase 1/Phase 2Denmark
75NCT04884880
(ClinicalTrials.gov)
May 14, 202130/4/2021Efficacy and Safety of Luo-Fu-Shan Plaster in Patients With Rheumatoid ArthritisProspective, Multicentre, Randomized, Double-blind, Placebo-controlled Clinical Trial of Luo-Fu-Shan Plaster in the Treatment of Rheumatoid ArthritisArthritis, RheumatoidDrug: Luo-Fu-Shan Plaster;Drug: The placebo 10gGuang'anmen Hospital of China Academy of Chinese Medical SciencesNULLNot yet recruiting18 Years75 YearsAll180N/AChina
76NCT04985435
(ClinicalTrials.gov)
May 12, 202119/7/2021Better After CHoosing. Randomly Allocated or Patient Preference Based Treatment With Filgotinib or TNFi in RA (BACH)Better After CHoosing. Randomly Allocated or Patient Preference Based Treatment With Filgotinib or TNFi in Patients With Active Rheumatoid Arthritis (BACH)Rheumatoid ArthritisDrug: Filgotinib;Drug: Anti-Tumor Necrosis Factor Alpha Drug (Product);Behavioral: 50 patients will have a Free Choice between Filgotinib and anti TNFR.BosGalapagos NV;Medical Centre Leeuwarden;Leiden University Medical CenterRecruiting18 Years101 YearsAll100Phase 4Netherlands
77NCT04947137
(ClinicalTrials.gov)
May 12, 202110/5/2021Development of a Normative Database for Rheumatoid Arthritis (RA) Imaging With Tc99m TilmanoceptDevelopment of a Normative Database for Rheumatoid Arthritis (RA) Imaging With Tc99m TilmanoceptRheumatoid ArthritisDrug: Tc99m tilmanoceptNavidea BiopharmaceuticalsNULLActive, not recruiting18 YearsN/AAll135Phase 2United States
78NCT04871919
(ClinicalTrials.gov)
May 11, 202129/4/2021Prospective Observational Study of Filgotinib in Subjects With Rheumatoid ArthritisA Prospective, Non-interventional Study of the Effectiveness, Safety, and Health Related Outcomes in Patients With Moderate to Severe Active Rheumatoid Arthritis Receiving FilgotinibRheumatoid ArthritisDrug: FilgotinibGalapagos NVNULLRecruiting18 YearsN/AAll1500Belgium;Germany;Italy;Netherlands;Spain;United Kingdom
79NCT04246762
(ClinicalTrials.gov)
April 6, 202127/1/2020Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4A Phase 1, Open-label, Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19, and CYP3A4Rheumatoid ArthritisDrug: Olokizumab;Drug: Omeprazole;Drug: Caffeine;Drug: Warfarin+ Vitamin K;Drug: MidazolamR-Pharm International, LLCIQVIA RDS Ireland Ltd;Thermo Fisher Scientific FSCompleted18 Years70 YearsAll16Phase 1Bulgaria;Moldova, Republic of
80NCT04815148
(ClinicalTrials.gov)
April 1, 202119/3/2021MH004 Topical Cream in Healthy Adult Volunteers and Participants With Atopic Dermatitis or Rheumatoid ArthritisA Phase Ia/Ib Study to Evaluate the Safety, Tolerability and PK of MH004 Topical Cream in Healthy Adult Volunteers and to Investigate Its Efficacy and Safety Profile in Participants With Atopic Dermatitis or Rheumatoid ArthritisAtopic Dermatitis;Rheumatoid ArthritisDrug: MH004 Ia(0.1%);Drug: MH004 Ia(0.3%);Drug: MH004 Ia(1%);Drug: MH004 Ia(3%);Drug: MH004 Ib-1(0.1%);Drug: MH004 Ib-1(0.3%);Drug: MH004 Ib-1(1%);Drug: MH004 Ib-2(0.3%);Drug: MH004 Ib-2(1%);Drug: MH004 Ib-2(3%)Minghui Pharmaceutical Pty LtdNULLNot yet recruiting18 Years70 YearsAll72Phase 1NULL
81NCT05247216
(ClinicalTrials.gov)
March 26, 202131/5/2021A Phase 2 Study of Hemay007 in Patients With Rheumatoid ArthritisA Multicenter, Randomized, Double-blind Phase 2 Study to Evaluate the Safety, Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Hemay007 in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: Hemay007 800 mg QD group;Drug: Hemay007 1200 mg QD group;Drug: Hemay007 600 mg QD group;Drug: Hemay007 placebo groupTianjin Hemay Pharmaceutical Co.,LtdNULLRecruiting18 Years75 YearsAll140Phase 2China
82NCT04286789
(ClinicalTrials.gov)
March 22, 202125/2/2020Randomized, Double-blind, Vehicle Controlled, Repeat Dose Comparative Study in RA Patients Managed With DMARDsA Randomized, Double-blind, Parallel, Vehicle Controlled, Repeat Dose Comparative Phase 1b Study to Evaluate the Safety, Tolerability and Pharmacokinetics of ORTD-1 in Rheumatoid Arthritis Patients With Mild Disease Managed With DMARDsRheumatoid ArthritisDrug: Low dose ORTD-1;Drug: Low dose vehicle control;Drug: High dose ORTD-1;Drug: High dose vehicle controlOryn Therapeutics, LLCNULLCompleted18 YearsN/AAll17Phase 1United States
83NCT04798287
(ClinicalTrials.gov)
March 10, 202111/3/2021Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)-Cancer EndpointsSafety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)-Cancer EndpointsRheumatoid ArthritisDrug: Tofacitinib;Drug: TNF InhibitorBrigham and Women's HospitalNULLCompleted18 YearsN/AAll105711United States
84NCT05090410
(ClinicalTrials.gov)
March 3, 202130/9/2021Efficacy and Safety of Selective JAK 1 Inhibitor Filgotinib in Active Rheumatoid Arthritis Patients With Inadequate Response to MethotrexateEfficacy and Safety of Selective JAK 1 Inhibitor Filgotinib in Active Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate: Comparative Study With Filgotinib and Tocilizumab Examined by Clinical Index as Well as Musculoskeletal Ultrasound AssessmentRheumatoid Arthritis;JAK Inhibitor;IL-6 Inhibitor;Musculoskeletal Ultrasound;BiomarkerDrug: filgotinib 200mg/day;Drug: subcutaneous tocilizumab 162mg/biweeklyAtsushi KawakamiGilead SciencesRecruiting20 YearsN/AAll400Phase 3Japan
85NCT04772248
(ClinicalTrials.gov)
February 22, 202123/2/2021Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular EndpointsSafety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular EndpointsRheumatoid ArthritisDrug: Tofacitinib;Drug: TNF InhibitorBrigham and Women's HospitalNULLCompleted18 YearsN/AAll105711United States
86NCT04757571
(ClinicalTrials.gov)
February 1, 202112/2/2021The GRK2 Inhibitor Paroxetine as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis PatientsThe GRK2 Inhibitor Paroxetine as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients. A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial.Rheumatoid ArthritisDrug: Paroxetine;Drug: PlaceboSadat City UniversityNULLRecruiting18 Years60 YearsAll120Phase 1/Phase 2Egypt
87NCT04530305
(ClinicalTrials.gov)
January 7, 202124/8/2020Microbiota Analysis to Predict Outcomes of Rheumatoid Arthritis Patients Treated With JAK-inhibitorMicrobiota Analysis to Predict Outcomes of Rheumatoid Arthritis Patients Treated With JAK-inhibitorRheumatoid ArthritisDrug: Tofacitinib 5 MG [Xeljanz]University Hospital, MontpellierNULLRecruiting18 YearsN/AAll60France
88NCT04535427
(ClinicalTrials.gov)
January 1, 202122/8/2020Role of L-Arginine Supplementation in the Treatment of Rheumatoid ArthritisRole of L-Arginine Supplementation in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: L-arginine;Drug: PlaceboRenJi HospitalNULLNot yet recruiting18 Years45 YearsAll144Phase 2China
89NCT04691505
(ClinicalTrials.gov)
December 23, 202028/12/2020Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs HydroxychloroquineData Analysis for Drug Repurposing for Effective Alzheimer's Medicines- Methotrexate vs HydroxychloroquineRheumatoid ArthritisDrug: Methotrexate;Drug: HydroxychloroquineBrigham and Women's HospitalNational Institute on Aging (NIA);Rutgers University;Johns Hopkins UniversityCompleted18 YearsN/AAll133553United States
90NCT04196868
(ClinicalTrials.gov)
December 3, 20205/12/2019Methotrexate and Metformin in Rheumatoid Arthritis PatientsRandomized Placebo-controlled Trial Comparing Methotrexate vs. Methotrexate/Metformin Association in Rheumatoid Arthritis PatientsArthritis, RheumatoidDrug: Metformin treatment;Other: Placebo;Drug: Methotrexate treatmentUniversity Hospital, BordeauxMinistry for Health and Solidarity, FranceRecruiting18 YearsN/AAll128Phase 2France
91NCT04649697
(ClinicalTrials.gov)
December 1, 202026/10/2020Rebamipide (Regular & Nanoparticulated) vs. Clobetasol in Management of Methotrexate-Induced Oral Ulceration in Rheumatoid Arthritis PatientsEvaluation of Topical Rebamipide Versus Topical Clobetasol in Management of Methotrexate-Induced Oral Ulceration in Rheumatoid Arthritis Patients: Randomized-Controlled Clinical TrialRheumatoid ArthritisDrug: Rebamipide;Drug: Nanoparticulated Rebamipide;Drug: Clobetasol PropionateCairo UniversityNULLNot yet recruiting20 Years70 YearsAll39Phase 3NULL
92NCT04569890
(ClinicalTrials.gov)
December 1, 202020/9/2020Treatment of Pregnancy RAStudy on the Treatment Strategy of Patients With Rheumatoid Arthritis During Pregnancy, a Randomized Control Trial in ChinaRheumatoid Arthritis;Pregnancy RelatedDrug: Certolizumab Pegol 200 MG/ML [Cimzia];Drug: Hydroxychloroquine;Drug: PrednisoneRenJi HospitalNULLNot yet recruiting20 Years40 YearsFemale100N/AChina
93NCT04311567
(ClinicalTrials.gov)
November 7, 20205/3/2020Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung DiseaseEffects of Tofacitinib vs Methotrexate on Clinical and Molecular Disease Activity Markers in Joints and Lungs in Early Rheumatoid Arthritis (PULMORA) - A Randomized, Controlled, Open-label, Assessor-blinded, Phase IV TrialRheumatoid Arthritis;Interstitial Lung Disease Due to Systemic Disease (Disorder);RA;ILDDrug: Tofacitinib;Drug: MethotrexateVastra Gotaland RegionGöteborg UniversityRecruiting18 Years80 YearsAll48Phase 4Sweden
94NCT04608344
(ClinicalTrials.gov)
November 4, 202023/10/2020Study to Evaluate Organic Anion Transporting Polypeptide (OATP) Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy ParticipantsA Phase 1 Study to Evaluate OATP Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy ParticipantsRheumatoid ArthritisDrug: Atorvastatin;Drug: Pravastatin;Drug: Rosuvastatin;Drug: FilgotinibGilead SciencesGalapagos NVCompleted18 Years55 YearsAll27Phase 1United States
95NCT04577781
(ClinicalTrials.gov)
October 12, 202030/9/2020A Study Evaluating the Effects of GLPG3970 Given as an Oral Treatment for 6 Weeks in Adults With Moderately to Severely Active Rheumatoid Arthritis and an Inadequate Response to MethotrexateA Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Safety, Tolerability, Efficacy and Pharmacokinetics of GLPG3970, Administered Orally for 6 Weeks in Adult Subjects With Moderately to Severely Active Rheumatoid Arthritis and an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: GLPG3970;Drug: PlaceboGalapagos NVNULLCompleted18 Years64 YearsAll28Phase 2Bulgaria;Georgia;Poland;Ukraine
96NCT04378621
(ClinicalTrials.gov)
October 1, 20208/4/2020Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patientsTreatment of Inflammation Versus Hand Training to Prevent and Revert Neuropsychiatric Comorbidity in Patients With Rheumatoid ArthritisRheumatoid Arthritis;Pain;Fatigue;Cognitive Decline;Depression;Brain Diseases;Hand RheumatismDrug: TNF-a inhibitor OR JAK inhibitor;Other: Hand trainingVastra Gotaland RegionNULLActive, not recruiting45 Years75 YearsAll212N/ASweden
97NCT04638426
(ClinicalTrials.gov)
September 10, 202013/11/2020Phase 2a Clinical Trial of HL237 for Rheumatoid ArthritisFor 12 Weeks, the Multi Center, Randomized, Double Blinded, Placebo Controlled, Parallel, Dose-finding Clinical Study for the Therapeutic Exploration of Safety and Efficacy Assessment of HL237 Tablet in Patients With Rheumatoid Arthritis (Phase IIa)Rheumatoid ArthritisDrug: HL237 tablet;Drug: Placebo of HL237 tabletHanlim Pharm. Co., Ltd.NULLEnrolling by invitation19 YearsN/AAll196Phase 2Korea, Republic of
98NCT04255134
(ClinicalTrials.gov)
September 7, 202014/11/2019Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)Comparison of Abatacept With Tumor Necrosis Factor Inhibitors in the Treatment of Rheumatoid Arthritis Pain: A Phase IV TrialRheumatoid ArthritisDrug: Abatacept Injection;Drug: Adalimumab InjectionSt George's, University of LondonNULLRecruiting18 Years75 YearsAll60Phase 4United Kingdom
99NCT04421313
(ClinicalTrials.gov)
September 2, 202018/5/2020Fibres Supplementation in Rheumatoid ArthritisSupplementation of Rheumatoid Arthritis Patients With Dietary Fibre to Improve Their Gut MicrobiotaRheumatoid ArthritisDrug: Dietary Fiber SupplementationUniversity Hospital, MontpellierUniversity of Sydney;Institut de Génétique Moléculaire de MontpellierRecruiting18 Years85 YearsAll87N/AFrance
100NCT04514614
(ClinicalTrials.gov)
September 1, 20207/8/2020Characterizing Rheumatoid Arthritis With 68Ga-FAPI PET/CTCharacterizing Rheumatoid Arthritis With 68Ga-FAPI PET/CTArthritisDrug: 68Ga-FAPIPeking Union Medical College HospitalNULLRecruiting18 Years90 YearsAll100Early Phase 1China
101NCT04529902
(ClinicalTrials.gov)
August 17, 202025/8/2020Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - TNFi vs AbataceptData Analysis for Drug Repurposing for Effective Alzheimer's Medicines - Tumor Necrosis Factor Inhibitors vs AbataceptRheumatoid ArthritisDrug: Tumor Necrosis Factor Inhibitors;Drug: AbataceptBrigham and Women's HospitalNational Institute on Aging (NIA);Rutgers University;Johns Hopkins UniversityCompleted18 YearsN/AAll63013United States
102NCT04529876
(ClinicalTrials.gov)
August 17, 202025/8/2020Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs AbataceptData Analysis for Drug Repurposing for Effective Alzheimer's Medicines - Tofacitinib vs AbataceptRheumatoid ArthritisDrug: Tofacitinib;Drug: AbataceptBrigham and Women's HospitalNational Institute on Aging (NIA);Rutgers University;Johns Hopkins UniversityCompleted18 YearsN/AAll29464United States
103NCT04529863
(ClinicalTrials.gov)
August 17, 202025/8/2020Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tocilizumab vs AbataceptData Analysis for Drug Repurposing for Effective Alzheimer's Medicines- Tocilizumab vs AbataceptRheumatoid ArthritisDrug: Tocilizumab;Drug: AbataceptBrigham and Women's HospitalNational Institute on Aging (NIA);Rutgers University;Johns Hopkins UniversityCompleted18 YearsN/AAll30432United States
104NCT05214677
(ClinicalTrials.gov)
August 15, 202012/12/2021A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809A Phase 1 Clinical Trial to Compare and Evaluate the Safety and Pharmacokinetic Characteristics After Administration of DW1809 and DW1809-1 in Healthy Adult VolunteersOsteoarthritis;Rheumatoid Arthritis;Back Pain;Acute Upper Respiratory Tract InfectionDrug: DW1809;Drug: DW1809-1Daewon Pharmaceutical Co., Ltd.NULLCompleted19 YearsN/AAll38Phase 1Korea, Republic of
105NCT05214690
(ClinicalTrials.gov)
August 13, 202012/12/2021A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809-T2A Phase 1 Clinical Trial to Compare and Evaluate the Safety and Pharmacokinetic Characteristics After Administration of DW1809-T2 and DW1809-1 in Healthy Adult VolunteersOsteoarthritis;Rheumatoid Arthritis;Back Pain;Acute Upper Respiratory Tract InfectionDrug: DW1809-T2;Drug: DW1809-1Daewon Pharmaceutical Co., Ltd.NULLCompleted19 YearsN/AAll37Phase 1Korea, Republic of
106NCT04512001
(ClinicalTrials.gov)
August 3, 202011/8/2020MSB11456 in Participants With Moderately to Severely Active Rheumatoid ArthritisA Randomized, Double-Blind, Multiple-Dose, Parallel-Group, Two-Arm Study to Evaluate the Efficacy, Safety and Immunogenicity of MSB11456 Compared to European Union-approved RoActemra® in Patients With Moderately to Severely Active Rheumatoid Arthritis (APTURA I Study)Rheumatoid ArthritisDrug: MSB11456;Drug: EU-approved RoActemraFresenius Kabi SwissBioSim GmbHNULLCompleted18 YearsN/AAll604Phase 3Bulgaria;Czechia;Georgia;Hungary;Moldova, Republic of;Poland;Russian Federation;Serbia;Slovakia
107NCT04333771
(ClinicalTrials.gov)
July 31, 20202/4/2020A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Rheumatoid ArthritisA Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Clinical Study to Evaluate the Efficacy and Safety of SHR0302 in Moderate to Severe Active Rheumatoid Arthritis Subjects With Inadequate Response to csDMARDs.Rheumatoid ArthritisDrug: SHR0302;Drug: PlaceboJiangsu HengRui Medicine Co., Ltd.NULLRecruiting18 Years75 YearsAll600Phase 3China
108NCT04413617
(ClinicalTrials.gov)
July 29, 202019/5/2020TO ASSESS THE EFFICACY AND SAFETY OF PF-06650833, PF-06651600, AND TOFACITINIB ALONE AND IN COMBINATION IN PARTICIPANTS WITH ACTIVE RHEUMATOID ARTHRITIS WITH AN INADEQUATE RESPONSE TO METHOTREXATEA 24-WEEK RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP, ACTIVE COMPARATOR, MULTICENTER STUDY TO ASSESS THE EFFICACY AND SAFETY OF PF-06650833, PF-06651600 (RITLECITINIB) AND TOFACITINIB ALONE AND IN COMBINATION IN PARTICIPANTS WITH MODERATELY-SEVERELY ACTIVE RHEUMATOID ARTHRITIS WITH AN INADEQUATE RESPONSE TO METHOTREXATERheumatoid ArthritisDrug: PF-06650833;Drug: PF-06651600;Drug: TofacitinibPfizerNULLCompleted18 Years70 YearsAll460Phase 2Bulgaria;Canada;Chile;Czechia;Georgia;Hungary;Poland;Slovakia;Spain;Ukraine;Bosnia and Herzegovina;Colombia;Sweden
109NCT05659407
(ClinicalTrials.gov)
July 24, 202013/12/2022BAFF-var as a Biomarker of Response to B-depletive Treatment in Systemic Lupus Erythematosus and Rheumatoid ArthritisThe BAFF-var Polymorphism as a Biomarker of Response to B-depletive Treatment in Patients Affected by Systemic Lupus Erythematosus and Rheumatoid Arthritis: a Prospective StudySystemic Lupus Erythematosus;Rheumatoid Arthritis;BLyS PolymorphismDrug: Belimumab in SLE patients / Rituximab in RA patientsUniversity of CagliariAzienda Ospedaliero Universitaria di CagliariRecruiting18 YearsN/AAll60Italy
110NCT04324892
(ClinicalTrials.gov)
July 12, 202025/3/2020Effects of Achieving SDAI Remission on Joint Space Outcomes Progression in Early Rheumatoid Arthritis: an HR-pQCT StudyEffects of Achieving SDAI Remission on Joint Space Outcomes Progression in Early Rheumatoid Arthritis: an HR-pQCT StudyRheumatoid ArthritisDrug: Treat to targetChinese University of Hong KongNULLNot yet recruiting18 YearsN/AAll110NULL
111NCT04428424
(ClinicalTrials.gov)
July 5, 202010/6/2020Study To Evaluate The Response To Enbrel And The Impact Of Rheumatoid Factor(RF) And Anti-Cyclic Citrullinated Peptide(Anti-CCP) In Rheumatoid Arthritis(RA) PatientsThe Impact of RF, and Anti-CCP on RA Patients in Response to EtanerceptArthritis, RheumatoidDrug: EnbrelPfizerNULLCompleted18 YearsN/AAll1Iraq
112NCT04163016
(ClinicalTrials.gov)
June 19, 202024/10/2019A Study in Pregnant Women With Chronic Inflammatory Diseases Treated With Cimzia (Certolizumab Pegol)A Postmarketing, Multicenter, Longitudinal, Prospective, Pharmacokinetic, Phase 1B Study in Pregnant Women With Chronic Inflammatory Diseases Treated With Cimzia (Certolizumab Pegol)Rheumatoid Arthritis;Psoriatic Arthritis;Crohn's Disease;Axial Spondyloarthritis;Plaque PsoriasisDrug: Pharmacokinetics of certolizumab pegolUCB Biopharma S.P.R.L.NULLActive, not recruiting18 YearsN/AFemale22Phase 1United States;France;Germany;Spain;Switzerland;Canada;Netherlands
113NCT05665985
(ClinicalTrials.gov)
May 1, 202026/11/2022Effect Of Moringa Leaf Extract On Disease Activity In Rheumatoid Arthritis PatientsEffect Of Moringa Leaf Extract On Disease Activity In Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Moringa OleiferaUniversitas Sebelas MaretNULLCompleted18 Years60 YearsFemale30Phase 1/Phase 2Indonesia
114NCT04350216
(ClinicalTrials.gov)
April 30, 20208/4/2020Effect of Sarilumab on Atherosclerotic Disease Assessed by PET/CET in Patients With RA (SARIPET)Effect of Sarilumab Therapy on Atherosclerotic Disease Assessed by Positron Emission Tomography/Computed Tomography (PET/CT) in Patients With Rheumatoid ArthritisRheumatoid Arthritis;AtherosclerosisDrug: Sarilumab 200 MG/1.14 ML Subcutaneous Solution [KEVZARA]Instituto de Investigación Marqués de ValdecillaNULLNot yet recruiting18 Years100 YearsAll20Phase 4NULL
115NCT04449224
(ClinicalTrials.gov)
April 27, 20207/6/2020Comparative Effectiveness of Targeted Therapy in RA PatientsComparative Effectiveness of Biologic Disease-modifying Antirheumatic Drugs and Small Molecular Inhibitors in Patients With Moderate to Severe RA: Prospective Observational StudyRheumatoid ArthritisDrug: Adalimuab, Etanercept, Tocilizumab, or Abatacept;Drug: Tofacitinib or BaricitinibHanyang UniversityMinistry of Health, Republic of KoreaRecruiting19 YearsN/AAll506Korea, Republic of
116NCT04361513
(ClinicalTrials.gov)
April 15, 202022/4/2020Genicular Nerve Block in Rheuamtoid ArthritisGenicular Nerve Block in Rheumatoid Arthritis: a Prospective Randomized Clinical TrialPain;Joint Function Disorder;InflammationDrug: Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer);Drug: triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip)Sohag UniversityNULLCompleted18 YearsN/AAll64Phase 4Egypt
117NCT04115423
(ClinicalTrials.gov)
April 1, 20202/10/2019A Retrospective Cohort Study on the Risk of Serious Infections in Rheumatoid Arthritis Patients Receiving TocilizumabA Retrospective Cohort Study to Examine the Risk of Serious Infections in Rheumatoid Arthritis Patients Receiving Tocilizumab Compared With Tumor Necrosis Factor Inhibitors Using the National Health Insurance DatabaseInfection;Rheumatoid ArthritisDrug: Tocilizumab;Drug: Tumor Necrosis Factor Inhibitor (etanercept, infliximab, adalimumab, and golimumab)Sungkyunkwan UniversityMinistry of Food and Drug Safety, KoreaActive, not recruiting18 YearsN/AAll9508Korea, Republic of
118NCT04434118
(ClinicalTrials.gov)
March 20, 202013/6/2020Anti-rheumatic Drug Use and Risk of COVID-19 Infection in Rheumatoid Arthritis PatientsAnti-rheumatic Drug Use and Risk of COVID-19 Infection in Rheumatoid Arthritis Patients: A Retrospective, Case-control StudyRheumatoid Arthritis;COVIDDrug: Traditional antirheumatic drugsSadat City UniversityNULLWithdrawn18 Years60 YearsAll0Egypt
119NCT04247815
(ClinicalTrials.gov)
March 16, 202016/1/2020Study of ATI-450 Plus Methotrexate (MTX) vs MTX Alone in Patients With Moderate to Severe RAA Phase 2a, Randomized, Investigator and Patient-blind, Sponsor-unblinded, Parallel Group, Placebo-controlled Study of ATI-450 Plus Methotrexate (MTX) vs MTX Alone in Patients With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: ATI-450;Drug: Placebo oral tablet;Drug: MethotrexateAclaris Therapeutics, Inc.NULLCompleted18 Years70 YearsAll19Phase 2United States
120NCT04389320
(ClinicalTrials.gov)
March 15, 202011/5/2020Antimalarial and Covid 19 in Rheumatoid ArthritisAntimalarial and Covid 19 in Rheumatoid ArthritisRheumatoid ArthritisDrug: HydroxychloroquineAssiut UniversityNULLCompleted20 Years70 YearsAll60Egypt
121NCT03559686
(ClinicalTrials.gov)
March 2, 20205/6/2018Named Patient Program With Certolizumab Pegol in Adults Suffering From Rheumatoid Aarthritis (RA)Named Patient Program With Certolizumab Pegol in Adults Suffering From Rheumatoid Arthritis (RA) Who Participated in Open Label Studies C87015, C87028 and C87051Rheumatoid ArthritisDrug: Certolizumab PegolUCB Biopharma S.P.R.L.NULLAvailable18 YearsN/AAllNULL
122NCT03976245
(ClinicalTrials.gov)
March 1, 20203/6/2019Advanced Therapeutics in Rheumatoid Arthritis (RA)Advanced Therapeutics in Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Etanercept;Drug: tofacitinibLawson Health Research InstituteAcademic Medical Organization of Southwestern OntarioRecruiting18 YearsN/AAll144Phase 4Canada
123NCT03895879
(ClinicalTrials.gov)
March 1, 202026/3/2019Use of Tocilizumab Drug Levels to Optimize Treatment in RAConcentration-guided Dose Reduction Versus Standard Dosing in Tocilizumab-treated Rheumatoid Arthritis Patients: a Randomised, Multicenter, Non-inferiority Trial (TODORA)Rheumatoid ArthritisDrug: TocilizumabReade Rheumatology Research InstituteZonMw: The Netherlands Organisation for Health Research and DevelopmentRecruiting18 YearsN/AAll98Phase 4Netherlands
124NCT04928066
(ClinicalTrials.gov)
March 1, 20209/6/2021The Efficacy and Safety of Tofacitinib (TF) With Iguratimod (IGU) on RAEfficacy and Safety of Tofacitinib (TF) Combined With Iguratimod(IGU) in the Treatment of Moderate to Severe Active Rheumatoid Arthritis (RA)Arthritis, RheumatoidDrug: Iguratimod;Drug: Tofacitinib;Drug: PredQilu Hospital of Shandong UniversityNULLRecruiting18 Years80 YearsAll100Phase 4China
125NCT04175886
(ClinicalTrials.gov)
February 25, 202020/11/2019Effects of Tofacitinib on Body Composition, Bone Mineral Density and Bone Marrow Adiposity in Patients With Rheumatoid Arthritis: the TOFAT ProjectEffects of Tofacitinib on Body Composition, Bone Mineral Density and Bone Marrow Adiposity in Patients With Rheumatoid Arthritis: the TOFAT ProjectRheumatoid ArthritisDrug: TofacitinibUniversity Hospital, LillePfizerRecruiting18 YearsN/AAll72France
126NCT04086745
(ClinicalTrials.gov)
February 14, 202010/9/2019A Study of Baricitinib in Participants With Rheumatoid ArthritisA Randomized, Controlled Pragmatic Phase 3b/4 Study of Baricitinib in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Baricitinib;Drug: TNF InhibitorEli Lilly and CompanyIncyte CorporationRecruiting18 YearsN/AAll1300Phase 4United States
127NCT04779892
(ClinicalTrials.gov)
February 1, 202026/2/2021The Study of Infliximab (CMAB008 and Remicade) in Healthy Subjects to Compare the PK and SafetyThe Study of Infliximab (CMAB008 and Remicade) in Healthy Subjects to Compare the PK and SafetyRheumatoid ArthritisDrug: InfliximabTaizhou Mabtech Pharmaceutical Co.,LtdNULLCompleted18 Years45 YearsMale90Phase 1China
128NCT04230213
(ClinicalTrials.gov)
January 13, 202014/1/2020A Comparative Study Between PF-06410293 and Humira® in Combination With Methotrexate in Participants With Active Rheumatoid ArthritisA RANDOMIZED COMPARATIVE STUDY ASSESSING THE SWITCHING BETWEEN PF-06410293 AND HUMIRA (REGISTERED) IN COMBINATION WITH METHOTREXATE IN PARTICIPANTS WITH MODERATELY TO SEVERELY ACTIVE RHEUMATOID ARTHRITISRheumatoid ArthritisDrug: PF-06410293;Drug: adalimumabPfizerNULLCompleted18 Years70 YearsAll455Phase 3United States;Bosnia and Herzegovina;Bulgaria;Czechia;Lithuania;Poland;Russian Federation;Serbia;South Africa;Ukraine
129NCT04186871
(ClinicalTrials.gov)
January 7, 202028/11/2019Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid ArthritisA Randomized, Placebo-Controlled, Double-Blind, Multicenter Study to Assess the Efficacy and Safety of Branebrutinib Treatment in Subjects With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Subjects With Active Rheumatoid ArthritisAutoimmune Disorder;Rheumatoid Arthritis;Systemic Lupus Erythematosus;Primary Sjögren's SyndromeDrug: branebrutinib;Drug: abatacept;Drug: branebrutinib placeboBristol-Myers SquibbNULLCompleted18 Years75 YearsAll112Phase 2United States;Argentina;Belgium;France;Germany;Mexico;Netherlands;Poland;Spain;United Kingdom;Australia
130NCT04115397
(ClinicalTrials.gov)
January 20202/10/2019Bisphosphonates for the Treatment of Seropositive Musculoskeletal ComplaintsTowards Efficient Prediction and Prevention of Rheumatoid ArthritisSeropositive Muskuloskeletal ComplaintsDrug: Zoledronic Acid;Drug: PlaceboKarolinska InstitutetNULLNot yet recruiting18 YearsN/AAll80Phase 4NULL
131NCT04046146
(ClinicalTrials.gov)
December 15, 201923/7/2019Near InfraRed Fluorescence Using Indocyanine Green and Magnetic Resonance Lymphography of Lymphatic TransportNear InfraRed Fluorescence Using Indocyanine Green and Magnetic Resonance Lymphography of Lymphatic TransportRheumatoid ArthritisDrug: Indocyanine Green;Device: MultiSpectral Imaging SystemUniversity of RochesterNULLCompleted18 Years89 YearsAll2Phase 1United States
132NCT04163991
(ClinicalTrials.gov)
December 9, 201912/11/2019A Study to Evaluate the Safety and Efficacy of VIB4920 in Participants With Rheumatoid ArthritisA Phase 2, Randomized, Double-Blind, Placebo-Controlled, Mechanistic Insight and Dosage Optimization Study of the Efficacy and Safety of VIB4920 in Patients With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: VIB4920;Drug: PlaceboViela BioNULLCompleted18 Years99 YearsAll78Phase 2United States;Poland
133NCT04136262
(ClinicalTrials.gov)
November 25, 201921/10/2019Tripterygium Wilfordii Hook F and Methotrexate for Postmenopausal Women With Rheumatoid ArthritisTripterygium Wilfordii Hook F and Methotrexate for Postmenopausal Women With Rheumatoid Arthritis: a Randomized Controlled TrialRheumatoid ArthritisDrug: Tripterygium wilfordii Hook F (TwHF);Drug: Methotrexate;Other: Dummy Tripterygium wilfordii Hook F (TwHF)Guang'anmen Hospital of China Academy of Chinese Medical SciencesNULLRecruitingN/AN/AFemale300Phase 2/Phase 3China
134NCT04485325
(ClinicalTrials.gov)
November 4, 201930/4/2020Capability of Tofacitinib or Etanercept to Accelerate Tapering of NSAID and Treat-to-target Guided De-escalation of Corticosteroids in RA PatientsCapability of Tofacitinib or Etanercept to Accelerate Clinical Relevant Tapering of Non-steroidal Anti-inflammatory Drugs (NSAID) and Treat-to-target Guided De-escalation of Corticosteroids in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Previous csDMARD Therapy (AcceleRAte)Rheumatic ArthritisDrug: Tofacitinib;Biological: EtanerceptDr. Frank BehrensPfizerRecruiting18 Years65 YearsAll192Phase 4Germany
135NCT04170504
(ClinicalTrials.gov)
November 201914/11/2019Efficacy of Chinese Herbal Medicine Qing Re Huo Xue in Patients With Rheumatoid ArthritisEfficacy of Chinese Herbal Medicine Qing Re Huo Xue in Patients With Rheumatoid Arthritis: A Randomized Controlled TrialRheumatoid ArthritisDrug: Qing Re Huo Xue (QRHX);Drug: Methotrexate;Drug: dummy Qing Re Huo Xue (QRHX)Guang'anmen Hospital of China Academy of Chinese Medical SciencesNULLNot yet recruiting18 YearsN/AAll204Phase 2/Phase 3NULL
136NCT04049448
(ClinicalTrials.gov)
October 24, 20196/8/2019Study Evaluating the Long-Term Safety and Efficacy of ABX464 in Patients With Moderate to Severe Rheumatoid ArthritisA Follow-up Phase 2a Open-label Study to Evaluate the Long-term Safety and Efficacy Profile of ABX464 in Patients With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: ABX464Abivax S.A.NULLCompleted18 Years76 YearsAll40Phase 2Belgium;Czechia;France;Hungary;Poland
137NCT04130178
(ClinicalTrials.gov)
October 15, 201911/10/2019Nerve Block of the Proximal Interphalangeal Joints PIPs in Rheumatoid Arthritis (RA) Patients: a Prospective Pilot StudyNerve Block of the Proximal Interphalyngeal Joints PIPs in Rheumatoid Arthritis (RA) Patients: a Prospective Pilot StudyRheumatoid ArthritisDrug: Nerve blockSohag UniversityNULLCompleted18 YearsN/AAll48N/AEgypt
138NCT04120831
(ClinicalTrials.gov)
October 7, 20194/10/2019TOLERA: Tolerance Enhancement in RASequential B Cell/T Cell Therapy to Re-induce Humoral Immune TOLErance in ACPA- Positive Rheumatoid Arthritis A Prospective, Randomized Controlled Open Label Single-centre Clinical Trial in Adult Subjects With Active ACPA-positive Rheumatoid Arthritis Failing MethotrexateRheumatoid ArthritisDrug: Abatacept InjectionUniversity of Erlangen-Nürnberg Medical SchoolNULLRecruiting18 YearsN/AAll20Phase 2Germany
139NCT03194204
(ClinicalTrials.gov)
October 1, 201910/6/2017Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled TrialEfficacy of Doxycycline as a Combination Therapy in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: Doxycycline TabletsAssiut UniversityNULLCompleted18 Years60 YearsAll160N/AEgypt
140NCT04273334
(ClinicalTrials.gov)
October 1, 201915/2/2020Application of 68Ga NEB PET Imaging in the Diagnosis and Evaluation of Lymphatic DisordersApplication of 68Ga NEB PET Imaging in the Diagnosis and Evaluation of Lymphatic Disorders, Including Lymphedema, Lymphangioma, Lymphangioleiomyomatosis, Plastic Bronchitis, Lymphadenopathy Caused by Rheumatoid Arthritis, Etc.Lymphatic DisordersDrug: 68Ga-NEBPeking Union Medical College HospitalNULLRecruiting18 Years80 YearsAll90Phase 1China
141NCT04077567
(ClinicalTrials.gov)
October 1, 201929/8/2019An Extension Study of TS-152 in Subjects With Rheumatoid ArthritisAn Extension Study of TS-152 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: TS-152Taisho Pharmaceutical Co., Ltd.NULLActive, not recruiting20 YearsN/AAll401Phase 3Japan
142NCT04472481
(ClinicalTrials.gov)
September 6, 20197/7/2020Vitamin D Effect in Rheumatoid Arthritis.Vitamin D: Does It Help Tregs in Active Rheumatoid Arthritis Patients.Active Rheumatoid ArthritisDrug: Ergocalciferol 1.25 mg tabletTanta UniversityNULLCompleted33 Years60 YearsAll20Phase 4Egypt
143NCT03971253
(ClinicalTrials.gov)
September 2, 201930/5/2019Japan Post-Marketing Surveillance for Peficitinib to Assess Safety and Effectiveness in the Patients With Rheumatoid ArthritisJapan Post-Marketing Surveillance - Specified Drug Use-results Survey for Peficitinib to Assess Safety and Effectiveness in the Patients With Rheumatoid ArthritisRheumatoid Arthritis (RA)Drug: PeficitinibAstellas Pharma IncNULLRecruitingN/AN/AAll3000Japan
144NCT04004429
(ClinicalTrials.gov)
August 26, 201926/6/2019A Study of the Safety, Tolerability and Efficacy of Treatment With AP1189 in Early RA Patients With Active Joint DiseaseA Double-blind, Multicenter, Two-part, Randomized, Placebo-controlled Study of the Safety, Tolerability, and Efficacy of 4 Weeks Treatment With AP1189 in Early Rheumatoid Arthritis (RA) Patients With Active Joint DiseaseRheumatoid ArthritisDrug: 50 mg AP1189;Drug: AP1189;Drug: PlaceboSynAct Pharma ApsNULLCompleted18 Years85 YearsAll105Phase 2Denmark;Norway
145NCT04068246
(ClinicalTrials.gov)
August 1, 201921/8/2019The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis PatientsThe AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial.Rheumatoid ArthritisDrug: Metformin;Drug: PlaceboSadat City UniversityNULLCompleted18 YearsN/AAll120Phase 1/Phase 2Egypt
146NCT02418273
(ClinicalTrials.gov)
August 1, 20196/4/2015Denosumab for Glucocorticoid-treated Children With Rheumatic DisordersDenosumab for Glucocorticoid-treated Children With Rheumatic Disorders: a Pilot StudyOsteoporosis;Juvenile Rheumatoid Arthritis;Dermatomyositis;Polyarthritis;Systemic Lupus Erythematosis;Vasculitis;Glucocorticoid-induced OsteoporosisDrug: denosumabIndiana UniversityNULLWithdrawn4 Years16 YearsAll0Phase 1/Phase 2United States
147NCT04018599
(ClinicalTrials.gov)
July 15, 201911/7/2019Comparison of PK and Tolerability of MSB11022 Administered by AI or PFSA Phase I, Randomized, Open-label, Parallel-group Study to Determine the Pharmacokinetics, Safety, and Tolerability of MSB11022 (Proposed Adalimumab Biosimilar) Following a Single Subcutaneous Injection by an Auto-injector or by a Pre-filled Syringe in Healthy SubjectsRheumatoid Arthritis;Polyarticular Juvenile Idiopathic Arthritis;Psoriatic Arthritis;Ankylosing Spondylitis;Crohn Disease;Ulcerative Colitis;Plaque Psoriasis;Pediatric Plaque Psoriasis;Pediatric Crohns Disease;Hidradenitis Suppurativa;Non-infectious UveitisDrug: 40 mg MSB11022Fresenius Kabi SwissBioSim GmbHPRA Health SciencesCompleted18 Years55 YearsAll216Phase 1United States
148NCT04464642
(ClinicalTrials.gov)
July 10, 20196/7/2020Tofacitinib Versus Methotrexate as the First Line DMARD in the Treatment of Rheumatoid ArthritisTofacitinib Versus Methotrexate as the First Line DMARD in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: Methotrexate;Drug: TofacitinibDr. Mohammad Mamun KhanNULLActive, not recruiting18 YearsN/AAll110Phase 4Bangladesh
149NCT03619876
(ClinicalTrials.gov)
July 10, 20193/8/2018Effects of Abatacept on Myocarditis in Rheumatoid ArthritisEffects of Abatacept on Myocarditis in Rheumatoid ArthritisRheumatoid Arthritis;Myocardial InflammationDrug: Abatacept;Drug: AdalimumabColumbia UniversityBristol-Myers SquibbRecruiting18 YearsN/AAll20Phase 4United States
150NCT03813199
(ClinicalTrials.gov)
July 4, 201915/1/2019Study of Two Doses of ABX464 in Participants With Moderate to Severe Rheumatoid ArthritisPhase IIa Randomized, Double Blind, Placebo Controlled, Multiple Dose Study on ABX464 in Combination With Methotrexate (MTX), in Patients With Moderate to Severe Active Rheumatoid Arthritis Who Have Inadequate Response to MTX or/and to Anti-Tnfa, or Intolerance to Anti-TnfaRheumatoid ArthritisDrug: ABX464 50mg;Drug: Matching Placebo;Drug: ABX464 100mg;Drug: MethotrexateAbivax S.A.NULLCompleted18 Years75 YearsAll60Phase 2Belgium;Czechia;France;Hungary;Poland
151NCT04188249
(ClinicalTrials.gov)
July 1, 201927/6/2019Effectiveness and Adherence of Golimumab in Rheumatoid ArthritisA Prospective Multicenter Registry of Golimumab in Chinese Patients With Rheumatoid ArthritisArthritis, RheumatoidDrug: GolimumabPeking Union Medical College HospitalNULLRecruiting18 Years80 YearsAll200China
152NCT03656627
(ClinicalTrials.gov)
June 27, 201931/8/2018Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune DiseaseSafety, Activity, and Pharmacology of Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune DiseaseAutoimmune Diseases;Non-small Cell Lung Cancer;Rheumatoid Arthritis;Psoriasis;Giant Cell Arteritis;Polymyalgia Rheumatica;Systemic Lupus Erythematosus;Crohn Disease;Multiple Sclerosis;Ulcerative ColitisDrug: NivolumabAlliance Foundation Trials, LLC.Bristol-Myers SquibbTerminated18 YearsN/AAll7Phase 1United States
153NCT03912428
(ClinicalTrials.gov)
June 14, 201910/4/2019Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and MyositisEvaluation of Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and MyositisMyositis;Inflammatory;Rheumatoid Arthritis;Healthy VolunteersDrug: Celecoxib;Diagnostic Test: 11C-MC1;Diagnostic Test: 11C-ER176National Institute of Mental Health (NIMH)NULLRecruiting18 Years99 YearsAll96Phase 1United States
154NCT03652961
(ClinicalTrials.gov)
June 2, 201923/8/2018Rheumatoid Arthritis Memory B Cells and AbataceptRheumatoid Arthritis Memory B Cells and Abatacept (RAMBA)Rheumatoid ArthritisDrug: Abatacept;Drug: DMARDsNYU Langone HealthDartmouth-Hitchcock Medical Center;Bristol-Myers SquibbActive, not recruiting18 YearsN/AAll25Phase 4United States
155NCT04344405
(ClinicalTrials.gov)
June 1, 20199/4/2020Vitamin D as a Key Player in Rheumatoid ArthritisVitamin D as a Key Player in Rheumatoid Arthritis Immune Responsethe Immunomodulatory EffectDrug: Vitamin D;Drug: Steroid DrugAssiut UniversityNULLCompleted20 Years70 YearsAll40Phase 3Egypt
156NCT03882008
(ClinicalTrials.gov)
May 23, 20197/11/2018A Study to Evaluate Biomarkers to Predict Efficacy of Abatacept in Rheumatoid ArthritisPhase IV Open-Label Study to Evaluate Biomarkers to Predict the Efficacy of Abatacept in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: AbataceptUniversity of WashingtonBristol-Myers SquibbEnrolling by invitation18 YearsN/AAll25Phase 4United States
157NCT03589833
(ClinicalTrials.gov)
May 14, 20195/7/2018Effectiveness and Safety of Yisaipu Combined With Tripterygium Wilfordii for Active RAEffectiveness and Safety of Tumor Necrosis Factor Receptor Fusion Protein(Yisaipu) Combined With Tripterygium Wilfordii for Active Rheumatoid ArthritisArthritis, RheumatoidDrug: Tripterygium Wilfordii;Drug: Methotrexate;Drug: YisaipuPeking Union Medical College HospitalNULLCompleted18 Years65 YearsAll504Phase 4China
158NCT03823378
(ClinicalTrials.gov)
May 13, 20198/1/2019A Study in Rheumatoid Arthritis Patients Who Have Completed a Preceding Study With ABBV-105 Given Alone or in Combination With Upadacitinib.A Phase 2, Multicenter, Double-Blind, Parallel Group Long Term Extension Study in Rheumatoid Arthritis Subjects Who Have Completed a Preceding Phase 2 Randomized Controlled Trial With ABBV-105 Given Alone or in Combination With Upadacitinib (ABBV-599)Rheumatoid Arthritis (RA)Drug: Upadacitinib;Drug: Upadacitinib placebo;Drug: ABBV-105 placebo;Drug: ABBV-105AbbVieNULLCompleted18 YearsN/AAll97Phase 2Belgium;Canada;Czechia;Hungary;Poland;Spain;United Kingdom
159NCT03938636
(ClinicalTrials.gov)
April 8, 201924/4/2019Evaluation of the Precision and Sensitivity of Tilmanocept Uptake Value (TUV) on Tc 99m Tilmanocept Planar ImagingEvaluation of the Precision and Sensitivity of Tilmanocept Uptake Value (TUV) on Tc 99m Tilmanocept Planar ImagingRheumatoid ArthritisDrug: TC99m-tilmanoceptNavidea BiopharmaceuticalsNULLCompleted18 YearsN/AAll95Phase 2United States
160NCT03669367
(ClinicalTrials.gov)
April 1, 201926/7/2018EFFECTS OF ABATACEPT on the Progression to Rheumatoid Arthritis(PALABA Study)EFFECTS OF ABATACEPT ON THE PROGRESSION TO RHEUMATOID ARTHRITIS IN PATIENTS WITH PALINDROMIC RHEUMATISM (PALABA)Palindromic Rheumatism, WristDrug: Abatacept Injection;Drug: hydroxycloroquinaFundacion Clinic per a la Recerca BiomédicaNULLNot yet recruiting18 YearsN/AAll98Phase 4NULL
161NCT03700021
(ClinicalTrials.gov)
April 20192/10/2018Response to Treatment With Intravenous Abatacept Adults With Rheumatoid ArthritisSingle-Open Label Study to Assess Changes in the Immune Profile in Response to Treatment With Intravenous Abatacept Adults With Rheumatoid Arthritis Who Are Naive to Biologic Disease-Modifying Antirheumatic DrugsRheumatoid ArthritisDrug: Abatacept + csDMARDNew York University School of MedicineNULLNot yet recruiting18 YearsN/AAll25Phase 4United States
162NCT03823391
(ClinicalTrials.gov)
March 27, 201929/1/2019A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of ABBV-3373 in Participants With Moderate to Severe Rheumatoid ArthritisA Randomized, Double-Blind, Double-Dummy, Active Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of ABBV-3373 in Subjects With Moderate to Severe Rheumatoid ArthritisRheumatoid Arthritis (RA)Drug: ABBV-3373;Drug: Placebo for ABBV-3373;Drug: Adalimumab;Drug: Placebo for adalimumabAbbVieNULLCompleted18 Years75 YearsAll48Phase 2United States;Germany;Hungary;Israel;Netherlands;Poland;Puerto Rico
163NCT04057118
(ClinicalTrials.gov)
March 20, 201913/8/2019A Study to Evaluate the Effectiveness and Safety of SKI-O-703 in Patients Experiencing Active Rheumatoid Arthritis Despite Treatment With Conventional Therapies.A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Dose Study to Evaluate the Efficacy and Safety of Oral SKI-O-703 in Patients With Active Rheumatoid Arthritis Despite Treatment With Conventional TherapiesRheumatoid ArthritisDrug: SKI-O-703;Drug: PlaceboOscotec Inc.NULLActive, not recruiting18 YearsN/AAll148Phase 2United States;Czechia;Poland;Russian Federation;Ukraine
164NCT03885037
(ClinicalTrials.gov)
March 20, 20194/3/2019Infliximab Biosimilar for Intravenous Drip Infusion 100 mg Pfizer Drug Use Investigation (Rheumatoid Arthritis)Infliximab BS for Intravenous Drip Infusion 100 mg Pfizer General Investigation (Rheumatoid Arthritis)Rheumatoid ArthritisDrug: Infliximab [infliximab biosimilar 3]PfizerNULLRecruiting0 YearsN/AAll300Japan
165NCT03890302
(ClinicalTrials.gov)
March 14, 201925/3/2019Evaluate the Safety, Tolerability, Pharmacokinetics,and Clinical Activity of FB704AA Phase 1, Randomized, Placebo-controlled, Double-blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of Single and Multiple Ascending Doses of FB704ARheumatoid ArthritisDrug: FB704A;Drug: PlaceboFountain Biopharma Inc.Oneness Biotech Co., Ltd.Completed18 Years55 YearsAll31Phase 1United States
166NCT03813771
(ClinicalTrials.gov)
March 201912/9/2018Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell StratificationTargeted Treatment Early With Etanercept Plus Methotrexate Versus T2T Care for DMARD-naïve Early RA Patients. A Prospective, Longitudinal Cohort Study With Embedded Pilot Randomised Controlled Trial to Assess Treatment Rationalisation Based on naïve T-cell Stratification.Rheumatoid ArthritisDrug: Benepali;Drug: Sulfasalazine;Drug: Methotrexate;Drug: HydroxychloroquineUniversity of LeedsSamsung Bioepis Co., Ltd.Not yet recruiting18 YearsN/AAll106Phase 4United Kingdom
167NCT03858725
(ClinicalTrials.gov)
February 26, 201927/2/2019Clinical Study to Evaluate the Pharmacokinetic Profiles and Safety of CKD-374 5 mg in Healthy VolunteersA Randomized, Open-label, Fasted, Single Dose, Crossover Study to Evaluate the Pharmacokinetic Profiles and Safety of CKD-374 5 mg in Healthy VolunteerRheumatoid ArthritisDrug: D569 Tab.;Drug: CKD-374 5mg Tab.Chong Kun Dang PharmaceuticalNULLCompleted19 Years54 YearsAll36Phase 1Korea, Republic of
168NCT03852355
(ClinicalTrials.gov)
February 25, 201922/2/2019the Effectiveness of 3rd Occipital Radiofrequency Versus Systemic Steroid in Headache Management in Rheumatoid Arthritisthe Effectiveness of 3rd Occipital Radiofrequency Versus Systemic Steroid in Headache Management in Rheumatoid Arthritis; a Randomized Controlled TrialRheumatoid Arthritis;HeadacheDrug: Radiofrequency;Drug: SteroidsAssiut UniversityNULLCompleted18 Years60 YearsAll60N/AEgypt
169NCT03868072
(ClinicalTrials.gov)
February 22, 20196/3/2019Study to Evaluate the Bioequivalence of Pfizer Korea Inc. XELJANZ 5Mg Tablet in Healthy VolunteersAn Open-label, Randomized, Fasted, Single Dose, Crossover Study to Evaluate the Bioequivalence of Chong Kun Dang Pharmaceutical Chong Kun Dang Tofacitinib Tablet and Pfizer Korea Inc. XELJANZ 5Mg Tablet in Healthy VolunteersRheumatoid ArthritisDrug: XELJANZ 5Mg Tablet;Drug: Chong Kun Dang Tofacitinib TabletChong Kun Dang PharmaceuticalNULLCompleted19 YearsN/AAll40Phase 1Korea, Republic of
170NCT03737708
(ClinicalTrials.gov)
February 13, 20198/11/2018A Study Comparing Biologics + Methotrexate With Biologics + Tacrolimus in Patients With Rheumatoid Arthritis (RA)Compare Efficacy and Safety Between Biologics + Methotrexate (MTX) vs Biologics + Tacrolimus (TAC) (Switched From Biologics + Methotrexate (MTX)) in the Patients With Rheumatoid Arthritis (RA): Randomized, Interventional, Open, Active Controlled, Parallel Group, Multicenter-designed, Phase 4 Clinical TrialRheumatoid Arthritis (RA)Drug: tacrolimus;Drug: methotrexate;Biological: adalimumab;Biological: tocilizumab;Biological: abataceptAstellas Pharma Korea, Inc.NULLCompleted19 Years75 YearsAll21Phase 4Korea, Republic of
171NCT03863405
(ClinicalTrials.gov)
January 9, 20194/3/2019Metformin Use in Rheumatoid ArthritisThe Effect of Metformin on the Clinical Outcome of Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Metformin;Drug: Conventional DMARDs;Drug: Placebo Oral TabletAin Shams UniversityFuture University in EgyptRecruiting18 YearsN/AAll60Phase 2Egypt
172NCT03981900
(ClinicalTrials.gov)
January 4, 20197/6/2019IDentification of Factors Predictive of Tofacitinib's Survival in Patient With Rheumatoid ArthritisIDentification of Predictive Factors of Continuation of Treatment With Tofacitinib in Patients With Rheumatoid Arthritis in Common Practice and the Impact of the Patient's Behavioural Strategies on Clinical Parameters: The DeFacTo Study.Arthritis, RheumatoidDrug: TofacitinibPfizerNULLRecruiting18 YearsN/AAll500France
173NCT03896594
(ClinicalTrials.gov)
December 24, 201828/3/2019A Multiple Dose of HL237 in Healthy Male SubjectA Dose Block-randomized, Double-blind, Placebo Controlled, Dose-escalation Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics After Multiple Oral Dose of HL237 in Healthy Male SubjectRheumatoid ArthritisDrug: HL237;Drug: Placebo Oral TabletHanlim Pharm. Co., Ltd.NULLRecruiting20 Years45 YearsMale36Phase 1Korea, Republic of
174NCT03830203
(ClinicalTrials.gov)
December 19, 201822/1/2019Comparative Study of BAT1806 to RoActemra® in Rheumatoid Arthritis Patients With Inadequate Response to MethotrexateA Randomized, Double-Blind, Parallel-Group, Active-Control Study to Compare the Efficacy and Safety of BAT1806 to RoActemra® in Rheumatoid Arthritis Patients With Inadequate Response to MethotrexateRheumatoid ArthritisDrug: BAT1806;Drug: Actemra(EU-licensed)Bio-Thera SolutionsNULLCompleted18 YearsN/AAll621Phase 3China
175NCT03784261
(ClinicalTrials.gov)
December 17, 201817/12/2018Usefulness of Non TNF Usage in RA PatientsUsefulness of Non TNF Usage in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Drug: Salirumab;Drug: Drug: Tocilizmab;Drug: Drug: AbataceptShinshu UniversityNULLRecruiting20 Years100 YearsAll90Phase 2Japan
176NCT03781310
(ClinicalTrials.gov)
December 201817/12/2018Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid ArthritisTherapeutic Drug Monitoring of Tocilizumab in Rheumatoid ArthritisRheumatoid Arthritis;TocilizumabDrug: TocilizumabTel-Aviv Sourasky Medical CenterAmsterdam Rheumatology and Immunology CenterUnknown status18 YearsN/AAll80Phase 4Israel
177NCT04204603
(ClinicalTrials.gov)
November 30, 201817/12/2019A Study Evaluating the Efficacy and Safety of CKD-506 in Adult Subjects With Moderate-to-Severe Rheumatoid Arthritis and Inadequate Response to MethotrexateA Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2a Study Investigating the Efficacy, Safety, Pharmacokinetic and Biomarker Profiles of CKD-506 Administered to Adult Subjects With Moderate-to- Severe Rheumatoid Arthritis and Inadequate Response to MethotrexateRheumatoid ArthritisDrug: CKD-506;Drug: PlaceboChong Kun Dang PharmaceuticalNULLCompleted18 Years65 YearsAll122Phase 2Czechia;Georgia;Poland;Russian Federation;Ukraine
178NCT03729674
(ClinicalTrials.gov)
November 26, 201811/10/2018Comparative Effectiveness and Safety of Biosimilar and Legacy DrugsComparative Effectiveness and Safety of Biosimilar and Legacy DrugsRheumatoid Arthritis;Ankylosing Spondylitis;Ulcerative Colitis;Crohn's DiseaseDrug: Biosimilar;Drug: Originator (legacy) drugMcGill University Health Centre/Research Institute of the McGill University Health CentreUniversité de Sherbrooke;Institut de rhumatologie de Montréal;Hospital for Special Surgery, New York;University of Manitoba;University of Toronto;University of Alberta;University of British Columbia;Alberta Health Services;McMaster University;The Arthritis Program Research GroupRecruiting18 YearsN/AAll800Canada
179NCT03755466
(ClinicalTrials.gov)
November 21, 201821/11/2018Examination of Efficacy and Safety of Baricitinib in RA PatientsEfficacy and Safety of Baricitinib in Rheumatoid Arthritis Patients Compared With Those Treated by Biologics or TofacitinibRheumatoid ArthritisDrug: Baricitinib, olumiant®;Drug: Biologics;Drug: Tofacitinib 5 MG [Xeljanz]Shinshu UniversityNULLRecruiting20 YearsN/AAll90Phase 2Japan
180NCT03980639
(ClinicalTrials.gov)
November 20, 201818/1/2019Abatacept and the Risk of Cancer: a Case Non-case Analysis in VigiBaseAbatacept and the Risk of Cancer: a Case Non-case Analysis in VigiBaseRheumatoid ArthritisDrug: patient treated with DMARDUniversity Hospital, ToulouseNULLRecruiting18 YearsN/AAll594226France
181NCT03714022
(ClinicalTrials.gov)
November 9, 201818/10/2018A Study to Evaluate the Pharmacokinetics of Abatacept Converted From Drug Substance by Two Different ProcessesA Randomized, Open-Label, Parallel-Group, Single-dose, Biocomparability Study of the Pharmacokinetics of the Abatacept (BMS-188667) Drug Product Converted From Drug Substance of a New Abatacept Drug Substance Process Relative to the Current Abatacept Drug Process in Healthy ParticipantsRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 Years55 YearsAll140Phase 1United States
182NCT04267614
(ClinicalTrials.gov)
November 1, 201811/2/2020This Study is to Investigate the Effect of Etanercept in Early Versus Delayed Referral for Management of Rheumatoid Arthritis Patients.Clinical Outcomes of Early Versus Delayed Management of Iraqi Patients With Rheumatoid Arthritis With EtanerceptArthritis RheumatoidDrug: EtanerceptPfizerNULLCompletedN/AN/AAll1226Iraq
183NCT03718611
(ClinicalTrials.gov)
October 22, 201823/10/2018To Evaluate the Pharmacokinetics and Safety of Oral Administration of BR9001 Compared With BR900A in Healthy SubjectsA Randomized, Open-label, Single-dose, Crossover Study to Evaluate the Pharmacokinetics and Safety of Oral Administration of BR9001 Compared With BR900A in Healthy SubjectsRheumatoid ArthritisDrug: BR9001;Drug: BR900ABoryung Pharmaceutical Co., LtdNULLCompleted19 Years50 YearsAll36Phase 1Korea, Republic of
184NCT03682705
(ClinicalTrials.gov)
October 8, 201821/9/2018A Study to Investigate the Safety and Efficacy of ABBV-105 Alone or in Combination With Upadacitinib (ABBV-599 Combination) in Participants With Active Rheumatoid Arthritis.A Phase 2 Study to Investigate the Safety and Efficacy of ABBV-105 Given Alone or in Combination With Upadacitinib (ABBV-599 Combination) With a Background of Conventional Synthetic DMARDs in Subjects With Active Rheumatoid Arthritis With Inadequate Response or Intolerance to Biologic DMARDsRheumatoid Arthritis (RA)Drug: Upadacitinib;Drug: ABBV-105;Drug: Upadacitinib placebo;Drug: ABBV-105 placeboAbbVieNULLCompleted18 YearsN/AAll242Phase 2United States;Belgium;Canada;Czechia;Hungary;Poland;Puerto Rico;Spain;United Kingdom;Germany;Ireland
185NCT03511625
(ClinicalTrials.gov)
October 2, 201810/4/2018The Effects of Acthar on Synovial Inflammation in Rheumatoid ArthritisThe Effects of Acthar on Synovial Inflammation in Rheumatoid Arthritis: A Pilot StudyRheumatoid ArthritisDrug: Acthar Injectable Product;Drug: Depo medrolAttune Health Research, Inc.MallinckrodtActive, not recruiting18 YearsN/AAll6Phase 3United States
186NCT03593837
(ClinicalTrials.gov)
October 1, 201810/7/2018Efficacy and Safety of HQGZWWT Patients With Rheumatoid ArthritisA Multicenter, Randomized, Double-blind,Placebo-controlled Trial Evaluating the Efficacy and Safety of Huang Qi GuiZhi Wu Wu Tang Granulesin Patients With Rheumatoid ArthritisHuang Qi Gui Zhi Wu Wu Granule;Rheumatoid ArthritisDrug: Huang qi gui zhi wu wu granule;Drug: Huang qi gui zhi wu wu granule placeboCui xuejunNULLUnknown status18 Years80 YearsAll100Phase 2/Phase 3NULL
187NCT03770923
(ClinicalTrials.gov)
October 1, 20187/12/2018Effect of Some Drugs on Rheumatoid Arithritis ActivityClinical Study Evaluating the Effect of Histamine 1 Receptor Antagonist and Leukotreine Receptor Antagonist on Patients With Rheumatoid ArithritisRheumatoid ArthritisDrug: Rupatadine;Drug: MontelukastSherief Abd-ElsalamNULLRecruiting18 YearsN/AAll75Phase 3Egypt
188NCT03770702
(ClinicalTrials.gov)
October 1, 20187/12/2018Statins and ARBs on Rheumatoid ActivityInvestigational and Comparative Study Between the Anti-inflammatory Effectof Both Angiotensin Reeptor Blockers and Statins on Rheumatoid Arthritis Disease Activity on Egyptian PatientsRheumatoid ArthritisDrug: Angiotensin receptor blockers;Drug: StatinsSherief Abd-ElsalamNULLRecruiting18 Years65 YearsAll45Phase 3Egypt
189NCT03546335
(ClinicalTrials.gov)
October 1, 201830/4/2018Zr-89 Cimzia PET Imaging Rheumatoid ArthritisZirconium-89 Certolizumab PET Imaging in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: 89Zr-DFO-CZPRobert Flavell, MD, PhDNULLSuspended18 YearsN/AAll10Phase 1United States
190NCT03660059
(ClinicalTrials.gov)
September 27, 201826/8/2018A Study to Assess Safety and Efficacy of ASP015K in Participants With Rheumatoid Arthritis (RA) Who Had an Inadequate Response or Intolerance to Methotrexate (MTX)A Randomized, Double-Blind, Placebo-Controlled Confirmatory Study of the Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response or Intolerance to MTXRheumatoid Arthritis (RA)Drug: Peficitinib;Drug: Plaebo;Drug: Disease-modifying antirheumatic drugs (DMARDs)Astellas Pharma China, Inc.NULLCompleted18 YearsN/AAll385Phase 3China;Korea, Republic of;Taiwan
191NCT03699293
(ClinicalTrials.gov)
September 22, 201821/9/2018NSAIDs vs. Coxibs in the Presence of AspirinNSAIDs vs. Coxibs in the Presence of Aspirin: Effects on Platelet Function, Endothelial Function, and Biomarkers of Inflammation in Subjects With Rheumatoid Arthritis and Increased Cardiovascular Risk or Cardiovascular DiseaseRheumatoid Arthritis;Cardiovascular DiseasesDrug: celecoxib 200mg capsule;Drug: naproxen sodium 550mg tablet;Drug: Aspirin 81mg tabletInova Health Care ServicesNULLUnknown status18 Years75 YearsAll30Phase 4United States
192NCT03701789
(ClinicalTrials.gov)
September 11, 20184/10/2018Effect of Baricitinib Treatment on Peripheral Bone in RAEvaluation of Bone Quality in Patients With Rheumatoid Arthritis Treated With Baricitinib: Single Centre, Mode of Action Study (BARE BONE)Rheumatoid Arthritis;Bone Density;Finger JointsDrug: BaricitinibUniversity of Erlangen-Nürnberg Medical SchoolNULLActive, not recruiting18 Years74 YearsAll15Phase 3Germany
193NCT04079374
(ClinicalTrials.gov)
September 3, 20183/9/2019Comparative Efficacy, Safety and Immunogenicity Study of Etanercept and EnbrelOpen, Randomized, Comparative, Multicenter Study in Parallel Groups of the Efficacy, Safety, Immunogenicity of Etanercept and Enbrel, Lyophilisates for Solution for Subcutaneous Injection, in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Etanercept;Drug: EnbrelJoint Stock Company FarmakSunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.Recruiting18 Years75 YearsAll160Phase 3Ukraine
194NCT02927522
(ClinicalTrials.gov)
September 1, 20185/10/2016Donepezil Attenuate Postoperative Cognitive DysfunctionDonepezil Attenuate Postoperative Cognitive Dysfunction in Aged Patients- A Multi-center, Case Control, Randomized Clinical TrailOsteoarthritis;Femoral Head Necrosis;Rheumatoid ArthritisDrug: Donepezil;Drug: PlaceboRenJi HospitalShanghai Guanghua Hospital of Integrated Traditional Chinese and Western MedicineRecruiting60 YearsN/AAll550Phase 3China
195NCT03605251
(ClinicalTrials.gov)
August 30, 20183/7/2018Efficacy and Safety Study of TAS5315 Compared With Placebo in Participants With Rheumatoid Arthritis.An Early Phase-II, Randomized, Double-blind, Study of TAS5315 in Rheumatoid Arthritis Patients With an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: TAS5315 low dose;Drug: TAS5315 high dose;Drug: PlacebosTaiho Pharmaceutical Co., Ltd.NULLCompleted20 Years64 YearsAll91Phase 2Japan
196NCT03636984
(ClinicalTrials.gov)
August 24, 201813/8/2018Efficacy and Safety Study of Anbainuo in Chinese Patients With RA/AS in the Real WorldEfficacy and Safety Study of Anbainuo in Chinese Patients With Rheumatoid Arthritis/ Ankylosing Spondylitis in the Real World: a Prospective, Open-label, Multi-center Observational StudyRheumatoid Arthritis;Ankylosing SpondylitisDrug: recombinant TNF-a receptor: IgG Fc fusion proteinZhejiang Hisun Pharmaceutical Co. Ltd.NULLNot yet recruiting18 YearsN/AAll1000NULL
197NCT04056039
(ClinicalTrials.gov)
August 14, 201821/6/2019Atorvastatin vs Colchicine in Decrease of Troponin I of High Sensitivity in Patients With Rheumatoid Arthritis.Efficacy of Atorvastatin vs Colchicine in Decrease of Troponin I of High Sensitivity as a Biomarker of Myocardial Damage in Patients With Rheumatoid Arthritis With Severe Activity.Cardiovascular Diseases;Arthritis, RheumatoidDrug: Atorvastatin;Drug: ColchicineHospital Central Dr. Ignacio Morones PrietoNULLCompleted18 YearsN/AAll60Phase 2Mexico
198NCT03535519
(ClinicalTrials.gov)
August 7, 201814/5/2018Rheumatoid Arthritis Response to MethotrexateRheumatoid Arthritis Ultrasound Response to MethotrexateRheumatoid ArthritisDrug: MethotrexateJuan Carlos NietoNordic Pharma SASRecruiting18 YearsN/AAll50Spain
199NCT04066803
(ClinicalTrials.gov)
August 1, 201811/12/2018Optimal MTX Dose With Folic Acid Randomized Case-control TrialSafety and Efficacy of Optimal Methotrexate With Folic Acid in Patients With Rheumatoid Arthritis in Meizhou, Guangdong: a Randomized Case-control StudyRheumatoid ArthritisDrug: MTX;Drug: Folic Acid;Drug: DMARDsSun Yat-sen UniversityShanghai Pharmaceuticals Holding Co., LtdRecruiting18 Years70 YearsAll160Phase 4China
200NCT03173040
(ClinicalTrials.gov)
July 201830/5/2017The Efficacy of the Traditional Chinese Medicine Niubang Pill Combined With Methotrexate on Active Rheumatoid ArthritisThe Efficacy of the Traditional Chinese Medicine Niubang Pill Combined With Methotrexate on Active Rheumatoid Arthritis: a Study Protocol for a Multicenter, Randomized, Controlled Clinical TrialNiu Bang Zi Pill;Rheumatoid ArthritisDrug: NiuBangZi pill or NiuBangZi pill placeboCui xuejunShanghai Yueyang Integrated Medicine Hospital;Longhua Hospital;Shanghai Seventh People's HospitalUnknown status18 Years80 YearsAll100Phase 2/Phase 3China
201NCT02885597
(ClinicalTrials.gov)
July 201818/8/2016Juanbi Pill for Rheumatoid ArthritisJuanbi Pill Combined With Methotrexate for Rheumatoid Arthritis: Multi-center Random Controlled Clinical TrialsJuanbi Pill;Rheumatoid ArthritisDrug: Juanbi pill;Drug: Juanbi pill placebo;Drug: MethotrexateCui xuejunShanghai Yueyang Integrated Medicine Hospital;Longhua Hospital;Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western MedicineUnknown status18 Years80 YearsAll120Phase 2/Phase 3China
202NCT03084419
(ClinicalTrials.gov)
June 26, 20187/3/2017APRIL (AbatacePt in Rheumatoid Arthritis-ILD)Safety of Abatacept in Rheumatoid Arthritis Associated Interstitial Lung Disease: A Feasibility TrialRheumatoid Arthritis;Interstitial Lung DiseaseDrug: AbataceptCambridge University Hospitals NHS Foundation TrustBristol-Myers SquibbRecruiting18 YearsN/AAll30Phase 2United Kingdom
203NCT03606876
(ClinicalTrials.gov)
June 13, 201812/7/2018Comparative Study to Evaluate the Pharmacokinetics of BAT1806 vs Actemra® in Healthy SubjectsA Randomized, Double-blinded, Single-dose, 3-arm Parallel, Comparative Study to Evaluate the Pharmacokinetics and Safety of BAT1806 Injection vs Actemra® in Healthy Chinese Male SubjectsRheumatoid ArthritisDrug: BAT1806 injectionBio-Thera SolutionsNULLCompleted18 Years55 YearsMale138Phase 1China
204NCT03535402
(ClinicalTrials.gov)
June 1, 20189/5/2018Measurement of the Structural Efficacy in Active RA Patients Treated With Sarilumab in Combination With MTX and Naive to BiologicsMeasurement of the Structural Efficacy in Active Rheumatoid Arthritis (RA) Patients Treated With Sarilumab in Combination With Methotrexate (MTX) and Naive to Biologics as Measured by Low-field MRI Using a Modified OMERACT-RAMRIS Score.Rheumatoid ArthritisDrug: SarilumabGaylis, Norman B., M.D.NULLActive, not recruiting18 YearsN/AAll20Phase 3United States
205NCT03522415
(ClinicalTrials.gov)
May 28, 201829/4/2018Study of Safety and Efficacy of HLX01+MTX in Patients With Rheumatoid ArthritisA Randomized, Double-blind, Placebo-controlled, Phase III Study to Evaluate the Efficacy and Safety of HLX01 (Recombinant Human-mouse Chimeric Anti-CD20 Monoclonal Antibody Injection) Combined With MTX Therapy in Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to MethotrexateModerately to Severely Active Rheumatoid ArthritisDrug: HLX01;Drug: Methotrexate(MTX)Shanghai Henlius BiotechNULLCompleted18 Years75 YearsAll275Phase 3China
206NCT03410056
(ClinicalTrials.gov)
May 22, 20183/1/2018Safety and Efficacy of AMG 592 in Subjects With Active Rheumatoid ArthritisA Phase 1b/2a Study to Evaluate the Safety and Efficacy of AMG 592 in Subjects With Active Rheumatoid Arthritis With Inadequate Response to Standard of Care TherapyRheumatoid Arthritis RADrug: AMG 592;Drug: PlaceboAmgenNULLTerminated18 Years70 YearsAll36Phase 1/Phase 2United States;Bulgaria;Germany;Poland;Spain
207NCT03378219
(ClinicalTrials.gov)
May 18, 201815/12/2017An Observational Study on Sarilumab-exposed PregnanciesKevzara® (Sarilumab) Pregnancy Exposure Registry: An OTIS Pregnancy Surveillance StudyRheumatoid Arthritis -Exposure During PregnancyDrug: Sarilumab SAR153191 (REGN88)SanofiRegeneron PharmaceuticalsActive, not recruitingN/AN/AFemale113United States;Canada
208NCT03508713
(ClinicalTrials.gov)
May 13, 20184/6/2017Long-term Prognosis and Quality of Life in Early Rheumatoid Arthritis Patients Treated by 2015 ACR Guideline (LELAND)Long-term Prognosis and Quality of Life in Early Rheumatoid Arthritis Patients Treated by 2015 ACR Guideline (LELAND): a Multicenter Prospective Observational Study in Southern ChinaRheumatoid ArthritisDrug: disease modified antirheumatic drugs or biological agentsNanfang Hospital of Southern Medical UniversitySouthern Medical University, ChinaNot yet recruiting18 YearsN/AAll200NULL
209NCT03505008
(ClinicalTrials.gov)
April 18, 201816/4/2018Evaluation of the Optimal MTX Dose as an Add-on Therapy to Adalimumab for RA Patients in Japan, South Korea and TaiwanMIRACLE (Methotrexate Inadequate Response Patient With Rheumatoid Arthritis Treated by Adalimumab in Combination With Low-dose Methotrexate) StudyRheumatoid ArthritisDrug: Methotrexate;Drug: AdalimumabKeio UniversityEisai Co., Ltd.Active, not recruiting18 YearsN/AAll300Phase 4Japan;Korea, Republic of;Taiwan
210NCT03435601
(ClinicalTrials.gov)
April 18, 201831/1/2018A Study to Target the Type I IFN Receptor by Administrating Anifrolumab in RA Patients With a High IFN Signature (TarIFNiRA)A Randomised, Double-blind, Placebo-controlled Phase II Study to Target the Type I IFN Receptor by Administrating Anifrolumab in RA Patients With a High IFN Signature (TarIFNiRA)Rheumatoid ArthritisDrug: Anifrolumab;Drug: PlacebosJosef Smolen, Univ. Prof. Dr.NULLRecruiting18 Years70 YearsAll24Phase 2Austria
211NCT03417778
(ClinicalTrials.gov)
April 3, 201825/1/2018Study to Evaluate the Pharmacokinetics of Filgotinib in Participants With Impaired Hepatic FunctionA Phase 1 Open-Label Study to Evaluate the Pharmacokinetics of Filgotinib in Subjects With Impaired Hepatic FunctionRheumatoid Arthritis;Ulcerative Colitis;Crohn's DiseaseDrug: FilgotinibGilead SciencesGalapagos NVCompleted18 Years70 YearsAll20Phase 1United States;Germany;New Zealand
212NCT03478111
(ClinicalTrials.gov)
March 30, 201816/3/2018CMAB008 With MTX Therapy in Adult Patients With Moderately to Severely Active Rheumatoid ArthritisA Randomized, Double-blind, Methotrexate (MTX) Based, Parallel-group, Multicenter Phase III Study to Evaluate Efficacy and Safety of CMAB008 in Adult Patients With Moderately to Severely Active Rheumatoid Arthritis, Compared to RemicadeRheumatoid ArthritisDrug: CMAB008;Drug: MTX;Drug: RemicadeShanghai Biomabs Pharmaceutical Co., Ltd.NULLCompleted18 YearsN/AAll390Phase 3China
213NCT03449758
(ClinicalTrials.gov)
March 5, 20188/2/2018Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid ArthritisEffect of Sarilumab on Patient-reported Outcomes in Patients With Moderately to Severely Active Rheumatoid Arthritis and With Inadequate Response or Intolerance to Current Conventional Synthetic DMARDs or Tumor Necrosis Factor InhibitorsRheumatoid ArthritisDrug: SARILUMAB;Drug: Azathioprine;Drug: Chloroquine;Drug: Hydroxychloroquine;Drug: Leflunomide;Drug: Methotrexate;Drug: SulfasalazineSanofiRegeneron PharmaceuticalsCompleted18 YearsN/AAll84Phase 4France
214NCT03100253
(ClinicalTrials.gov)
March 1, 201817/3/2017Rheumatoid Arthritis Treatment After First Anti-TNF INvestiGationOpen-label, Randomized Controlled Trial Comparing Tocilizumab to Anti-TNF Treatment and Discovery of Biomarkers for Treatment Selection in Rheumatoid Arthritis Patients With Inadequate Response to a First Anti-TNFRheumatoid ArthritisDrug: Tocilizumab;Drug: Etanercept;Drug: Infliximab;Drug: Adalimumab;Drug: Golimumab;Drug: Certolizumab PegolMario Negri Institute for Pharmacological ResearchNULLTerminated18 YearsN/AAll208Phase 4Italy
215NCT03480529
(ClinicalTrials.gov)
March 1, 201821/3/2018Monitoring the IMmUological TOXicity of DrugsMonitoring the IMmUological TOXicity of DrugsArthritis;Systemic Lupus Erythematosus;Rheumatoid Arthritis;Capillary Leak Syndrome;HepatitisDrug: drug inducing arthritis, lupus, hepatitis, or capillary leak syndromGroupe Hospitalier Pitie-SalpetriereInstitut National de la Santé Et de la Recherche Médicale, FranceCompleted18 YearsN/AAll662France
216NCT04022525
(ClinicalTrials.gov)
February 1, 201815/7/2019Assessment of Leflunomide Efficacy and Hepatotoxicity in Patients With Rheumatoid Arthritis Through Pharmacokinetic and Genetic ApproachesAssessment of Leflunomide Efficacy and Hepatotoxicity in Patients With Rheumatoid Arthritis Through Pharmacokinetic and Genetic ApproachesRheumatoid ArthritisDrug: Leflunomide 20Mg TabAssiut UniversityNULLCompleted18 YearsN/AAll80Egypt
217NCT01694693
(ClinicalTrials.gov)
January 31, 201824/9/2012Description of Joint Population and Assessment of Impact on Health Status of Orencia in Patients With Rheumatoid Arthritis in France. A Database Analysis Based on SFR's ORA Long-term Cohort StudyDescription of Joint Population and Assessment of Impact on Health Status of Orencia in Patients With Rheumatoid Arthritis in France. A Database Analysis Based on SFR's ORA Long-term Cohort StudyRheumatoid ArthritisDrug: OrenciaBristol-Myers SquibbNULLWithdrawn18 YearsN/AAll0N/ANULL
218NCT03227419
(ClinicalTrials.gov)
January 22, 201819/7/2017Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate RespondersAbatacept Versus Tocilizumab by Subcutaneous Administration for the Treatment of Rheumatoid Arthritis in TNF Alpha Inhibitor Inadequate Responder Patients: A Randomized, Open-labeled, Superiority TrialArthritis, RheumatoidDrug: Tocilizumab Prefilled Syringe;Drug: Abatacept Prefilled SyringeLille Catholic UniversityNULLRecruiting18 YearsN/AAll224Phase 4France
219NCT03368235
(ClinicalTrials.gov)
January 18, 20183/11/2017Early Phase Study to Assess Efficacy and Safety of AZD9567 Versus Prednisolone in Patients With Rheumatoid ArthritisA Phase 2a, Randomised, Double-blind, Parallel Study to Assess the Efficacy, Safety and Tolerability of AZD9567 Compared to Prednisolone 20 mg in Patients With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: AZD9567;Drug: PrednisoloneAstraZenecaNULLCompleted18 Years80 YearsAll21Phase 2Netherlands;Sweden;Denmark
220NCT02955212
(ClinicalTrials.gov)
January 3, 20182/11/2016A Study With Upadacitinib (ABT-494) in Subjects From China and Selected Countries With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs)A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study With Upadacitinib (ABT-494) in Subjects From China and Selected Countries With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs)Rheumatoid Arthritis (RA)Drug: Upadacitinib;Drug: PlaceboAbbVieNULLCompleted18 YearsN/AAll338Phase 3Brazil;China;Korea, Republic of
221NCT02795299
(ClinicalTrials.gov)
January 20182/5/2016Study Evaluating Gerilimzumab´s Safety/Efficacy for Patients MTX or TNFa Antagonist Failed in Rheumatoid ArthritisPhase 2, Rand, Placebo-Controlled, Double-Blind, Dose Ranging Study to Evaluating Safety/Efficacy of Gerilimzumab in Patients With Moderately to Severely Active Rheumatoid Arthritis Inadequately Treated With Methotrexate or TNFa AntagonistRheumatoid ArthritisDrug: Gerilimzumab;Drug: Methotrexate;Drug: Folic Acid;Drug: PlaceboBird Rock Bio, Inc.Techtrials Pesquisa e Tecnologia Ltda;PharmagenixWithdrawn18 Years80 YearsAll0Phase 2NULL
222NCT04312815
(ClinicalTrials.gov)
December 28, 201716/3/2020A Study Assessing the Efficacy and Safety of SM03 in Patients With Active Rheumatoid Arthritis Receiving MTXA Randomized,Placebo Controlled, Double-blind, Parallel Group, Phase III Study to Evaluate the Efficacy and Safety of SM03, Compared to Placebo, in Patients With Moderate-to-Severely Active Rheumatoid Arthritis Receiving MethotrexateRheumatoid Arthritis(RA)Drug: SM03;Drug: Placebo;Drug: MTXSinoMab Pty LtdNULLRecruiting18 Years70 YearsAll510Phase 3China
223NCT03254966
(ClinicalTrials.gov)
November 24, 201715/8/2017Study of SHR0302 Tablets (SHR0302) as Monotherapy in Active Rheumatoid Arthritis (RA) PatientsRandomized, Double-blind, Placebo-controlled, Multicenter, Phase II Study to Assess the Safety and Efficacy of SHR0302 in Patients With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: SHR0302;Drug: PlaceboJiangsu HengRui Medicine Co., Ltd.NULLCompleted18 Years70 YearsAll194Phase 2China
224NCT03334851
(ClinicalTrials.gov)
November 17, 20173/11/2017Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid ArthritisA PHASE 1, RANDOMIZED, MULTI-CENTER, DOUBLE-BLIND, SPONSOR OPEN, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE DOSE-ESCALATION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF-06835375 IN SUBJECTS WITH SEROPOSITIVE SYSTEMIC LUPUS ERYTHEMATOSUS OR RHEUMATOID ARTHRITISSystemic Lupus Erythematosus;Rheumatoid ArthritisDrug: PF-06835375;Drug: PlaceboPfizerNULLCompleted18 Years70 YearsAll74Phase 1United States;Puerto Rico
225NCT03357471
(ClinicalTrials.gov)
November 3, 201723/11/2017Study to Test the Safe and Effective Use of an e-Device for the Self-injection of Certolizumab Pegol Solution by Subjects With Moderate to Severe Active Rheumatoid Arthritis, Active Ankylosing Spondylitis, Active Psoriatic Arthritis, or Moderately to Severely Active Crohn's DiseaseA Multicenter, Open-Label Study to Evaluate the Safe and Effective Use of an Electro-Mechanical Injection Device (E-Device) for the Subcutaneous Self-Injection of Certolizumab Pegol Solution by Subjects With Moderate to Severe Active Rheumatoid Arthritis, Active Ankylosing Spondylitis, Active Psoriatic Arthritis, or Moderately to Severely Active Crohn's DiseaseModerate and Severe Active Rheumatoid Arthritis;Active Psoriatic Arthritis;Active Ankylosing Spondylitis;Moderately to Severely Active Crohn's DiseaseDrug: e-DeviceUCB Biopharma S.P.R.L.NULLCompleted18 YearsN/AAll70Phase 3United States
226NCT03387423
(ClinicalTrials.gov)
November 2, 20177/12/2017Observational Study to Determine How Physicians Make Treatment Decisions in Patients Treated With Tofacitinib for Moderate to Severe Active Rheumatoid ArthritisESCALATE-RA A NON-INTERVENTIONAL STUDY OF CRITICAL FACTORS FOR ESCALATING DRUG TREATMENT IN PATIENTS TREATED WITH TOFACITINIB FOR MODERATE TO SEVERE ACTIVE RHEUMATOID ARTHRITISArthritis, RheumatoidDrug: TofacitinibPfizerNULLRecruiting18 YearsN/AAll1500Germany
227NCT03329885
(ClinicalTrials.gov)
November 2, 201731/10/2017A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Participants and Patients With Average to Very Serious PsoriasisA Double-Blind Randomized Placebo-Controlled Single and Multiple Ascending Doses Study of the Safety and Tolerability, Pharmacokinetics (Including Bioavailability Comparison and Food Effect) and Pharmacodynamics of Oral BMS-986251 Administration in Healthy Subjects, With Efficacy Assessment of Multiple Doses in Patients With Moderate-to-Severe PsoriasisRheumatoid Arthritis;Psoriasis;Ankylosing Spondylitis;Inflammatory Bowel Diseases;Nonalcoholic SteatohepatitisDrug: BMS-986251;Other: PlaceboBristol-Myers SquibbNULLTerminated18 Years70 YearsAll38Phase 1/Phase 2Netherlands
228NCT03440892
(ClinicalTrials.gov)
November 1, 201714/2/2018Effects of Antirheumatic Treatment on Levels of Survivin in Rheumatoid Arthritis PatientsLongitudinal Observational Study on Rheumatoid Arthritis Patients: Effects of Antirheumatic Treatment on Serum Levels of SurvivinRheumatoid ArthritisDrug: methotrexate;Drug: sulfasalazine;Drug: abatacept;Drug: tocilizumab;Drug: tofacitinib/baricitinibVastra Gotaland RegionNULLRecruiting20 YearsN/AAll2500Sweden
229NCT02647762
(ClinicalTrials.gov)
October 30, 201716/12/2015CF101 Therapy Compared to Methotrexate Therapy for Active Rheumatoid ArthritisA Phase 3, Randomized, Double-Blind, Active- and Placebo-controlled, Parallel-group Trial to Evaluate the Efficacy and Safety of CF101 Compared to Methotrexate in the Treatment of Early Rheumatoid ArthritisRheumatoid ArthritisDrug: CF101 1 mg;Drug: CF101 2 mg;Drug: Placebo;Drug: MTXCan-Fite BioPharmaNULLActive, not recruiting18 Years75 YearsAll525Phase 3Bosnia and Herzegovina;Canada;Israel;Moldova, Republic of;Poland;Romania;Serbia
230NCT03324412
(ClinicalTrials.gov)
October 28, 201725/10/2017Efficacy and Safety of TwHF and MTX in Patients With Rheumatoid ArthritisA 24-Week, Multicenter ,Double Blind, Randomized Study to Determine the Effects and Security of TwHF and MTX Treating Rheumatoid ArthritisRheumatoid ArthritisDrug: Treatment of MTX;Drug: Treatment of MTX and TwHFGuang'anmen Hospital of China Academy of Chinese Medical SciencesNULLNot yet recruiting45 Years70 YearsAll216Phase 2/Phase 3NULL
231NCT03337815
(ClinicalTrials.gov)
October 28, 201722/10/2017A Specification Clinical Application Research of Tripterygium Wilfordii Treating Rheumatoid ArthritisA 24-Week, Multicenter ,Double Blind, Randomized Study to Determine the Effects and Security of Tripterygium Wilfordii Treating Rheumatoid Arthritis and Establish A Prediction ModelRheumatoid ArthritisDrug: Treatment of MTX and TwHF placebo;Drug: Treatment of TwHF and MTX placeboGuang'anmen Hospital of China Academy of Chinese Medical SciencesNULLRecruiting45 Years70 YearsAll264Phase 2/Phase 3China
232NCT03288584
(ClinicalTrials.gov)
October 27, 201716/9/2017Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid ArthritisThe Effect of Inhibition of Interleukin-6 Activity on Vascular, Endothelial and Left Ventricular Function in Patients With Rheumatoid ArthritisRheumatoid Arthritis;InflammationDrug: Tocilizumab (Actemra®);Drug: Other biological agent;Drug: Corticosteroid and non-biological agents.University of AthensNULLRecruiting18 Years80 YearsAll60Greece
233NCT03163966
(ClinicalTrials.gov)
October 5, 20178/5/2017A Study of the EP4 Antagonist CR6086 in Combination With Methotrexate, in DMARD-naïve Patients With Early Rheumatoid ArthritisA Randomized, Double Blind, Placebo-controlled, Dose Response, Phase II, Multicentre Trial to Evaluate the Efficacy, Safety and Pharmacokinetics of Oral CR6086 Administered at the Doses of 30, 90 or 180 mg Bid for 12 Weeks in Combination With Methotrexate, in DMARD-naïve Patients With Early Rheumatoid ArthritisRheumatoid Arthritis, DMARD-naive and Early Disease PatientsDrug: CR6086;Drug: Methotrexate;Drug: PlaceboRottapharm BiotechNULLCompleted18 YearsN/AAll248Phase 2Czechia
234NCT03257852
(ClinicalTrials.gov)
September 29, 201720/8/2017A Study to Evaluate the Efficacy and Safety of ASP5094 in Patients With Rheumatoid Arthritis on MethotrexateA Phase 2a, Randomized, Placebo-Controlled, Double-Blind, Parallel Group Study to Evaluate the Efficacy and Safety of ASP5094 in Patients With Rheumatoid Arthritis on MethotrexateRheumatoid Arthritis (RA)Drug: ASP5094;Drug: Placebo;Other: Methotrexate therapyAstellas Pharma IncNULLCompleted20 YearsN/AAll66Phase 2Japan
235NCT03233230
(ClinicalTrials.gov)
September 18, 201725/7/2017Phase IIb Study of Evobrutinib in Subjects With Rheumatoid ArthritisA Phase IIb, Randomized, Double-blind Study in Subjects With Rheumatoid Arthritis Evaluating the Safety and Efficacy of Evobrutinib Compared With Placebo in Subjects With an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: M2591 25 mg QD;Drug: M2951 75 mg QD;Drug: M2951 50 mg BID;Drug: PlaceboEMD Serono Research & Development Institute, Inc.Merck KGaA, Darmstadt, GermanyCompleted18 Years75 YearsAll390Phase 2United States;Argentina;Bulgaria;Chile;Colombia;Czechia;Mexico;Poland;Russian Federation;Serbia;South Africa;Ukraine;Brazil;Germany;Hungary;Romania;Slovakia;Spain
236NCT03262740
(ClinicalTrials.gov)
September 11, 201724/8/2017The Effect of BMS-986195 Combined With an Oral Contraceptive (Ethinyl Estradiol/Norethindrone) in Healthy Female PatientsThe Effect of BMS-986195 on the Pharmacokinetics of a Combined Oral Contraceptive (Ethinyl Estradiol/Norethindrone) in Healthy Female SubjectsRheumatoid ArthritisDrug: BMS-986195;Drug: Loestrin 1.5/30 (1.5 mg norethindrone acetate/30 µg ethinyl estradiol)Bristol-Myers SquibbNULLCompleted18 Years40 YearsFemale58Phase 1United States
237NCT04177173
(ClinicalTrials.gov)
September 1, 20177/4/2019Methotrexate and Statins With Methotrexate Alone in the Treatment of Rheumatoid ArthritisComparison of Combination of Methotrexate and Statins With Methotrexate Alone as an Anti-inflammatory Agent in the Treatment of Rheumatoid Arthritis.Arthritis, RheumatoidDrug: Simvastatin 20 mg;Drug: Methotrexate 10 mgKing Edward Medical UniversityNULLCompleted18 YearsN/AAll100Phase 4Pakistan
238NCT03241446
(ClinicalTrials.gov)
September 201725/7/2017Pharmacokinetics and Dosimetry of Tc 99m Tilmanocept Following a Single Intravenous Dose Administration in Male and Female Subjects Diagnosed With Rheumatoid Arthritis (RA)A Phase I, Open-Label Study to Investigate the Pharmacokinetics and Dosimetry of Tc 99m Tilmanocept Following a Single Intravenous Dose Administration in Male and Female Subjects Diagnosed With Rheumatoid ArthritisArthritis, RheumatoidDrug: TilmanoceptNavidea BiopharmaceuticalsNULLWithdrawn30 Years65 YearsAll0Phase 1NULL
239NCT03160001
(ClinicalTrials.gov)
August 15, 201711/5/2017Niclosamide With Etanercept in Rheumatoid ArthritisAdjuvant Use of Niclosamide With Etanercept in Rheumatoid Arthritis: Experimental and Clinical StudyRheumatoid Arthritis (RA)Drug: Placebo;Drug: Niclosamide;Drug: EtanerceptFaiq GorialNULLCompleted18 YearsN/AAll110Phase 1/Phase 2Iraq
240NCT03245515
(ClinicalTrials.gov)
August 15, 20178/8/2017A Study of BMS-986195 in Healthy Male SubjectsPharmacokinetics and Metabolism of [14C] BMS-986195 in Healthy Male SubjectsRheumatoid ArthritisDrug: BMS-986195Bristol-Myers SquibbNULLCompleted18 Years55 YearsMale24Phase 1Netherlands
241NCT03156023
(ClinicalTrials.gov)
August 14, 201715/5/2017Multiple Ascending Doses of AMG 570 in Subjects With Rheumatoid ArthritisA Randomized, Double Blind Placebo Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Subcutaneous Doses of AMG 570 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: AMG 570;Drug: PlaceboAmgenNULLCompleted18 Years75 YearsAll34Phase 1United States;Germany
242NCT03188081
(ClinicalTrials.gov)
August 4, 201712/6/2017A Study to Investigate the Effectiveness of an Education Support Program on Medication Adherence in Italian Real Life Rheumatoid Arthritis (RA) Patients Treated With Subcutaneous (SC) AbataceptA Prospective, Multicentric, Observational Study to Investigate the Effectiveness of an Education Support Program on Medication Adherence in Italian Real Life RA Patients Treated With Abatacept SCRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLRecruiting18 YearsN/AAll300Italy
243NCT03155347
(ClinicalTrials.gov)
August 2, 201715/5/2017An Efficacy and Safety Study of Subcutaneous Tocilizumab in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Participants With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current Disease-Modifying Antirheumatic Drug (DMARD) TherapyA Randomized, Multi-Center, Double Blind, Parallel-Group Study to Evaluate the Efficacy and Safety of Subcutaneous (SC) Tocilizumab (TCZ) in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Patients With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current DMARD TherapyRheumatoid ArthritisDrug: Tocilizumab;Drug: MTX;Drug: Placebo Matched to MTX;Drug: Placebo Matched to TocilizumabHoffmann-La RocheNULLCompleted18 Years70 YearsAll340Phase 3China
244NCT03215407
(ClinicalTrials.gov)
August 1, 201722/6/2017The Comparative Study of Intra-articular Injection of Tocilizumab and Compound BetamethasoneThe Comparative Study of Safety and Effectiveness of Intra-articular Injection of Tocilizumab and Compound Betamethasone in Rheumatoid Arthritis of the KneeRheumatoid Arthritis of KneeDrug: Intra-articular Tocilizumab;Drug: Intra-articular Compound BetamethasoneChinese PLA General HospitalNULLNot yet recruiting18 Years65 YearsAll60Phase 4NULL
245NCT02541955
(ClinicalTrials.gov)
July 20, 20171/9/2015Use of Acthar in Rheumatoid Arthritis (RA) Related FlaresUse of Acthar in Rheumatoid Arthritis Related FlaresRheumatoid Arthritis (RA)Drug: ActharVeena Ranganath, MD, MSNULLRecruiting18 YearsN/AAll40Phase 4United States
246NCT03120949
(ClinicalTrials.gov)
July 4, 20177/2/2017Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid ArthritisA Multicenter, Open-Label, Phase III Study of the Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Olokizumab 64 mg SC q4w;Drug: Olokizumab 64 mg SC q2wR-Pharm International, LLCIQVIA Pvt. Ltd;OCT Clinical TrialsCompleted18 YearsN/AAll2106Phase 3United States;Argentina;Belarus;Brazil;Bulgaria;Colombia;Czechia;Estonia;Latvia;Lithuania;Mexico;Poland;Romania;Russian Federation;Taiwan;United Kingdom;Korea, Republic of;Germany;Hungary
247NCT03189017
(ClinicalTrials.gov)
July 3, 201712/6/2017A Phase I Study of ICP-022 in Healthy SubjectsA Phase I Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Trial in Healthy Subjects to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ICP-022 Following Single and Multiple Escalating DoseSystemic Lupus Erythematosus;Rheumatoid ArthritisDrug: ICP-022;Drug: PlacebosInnocare Pharma Australia Pty LtdNULLCompleted18 Years55 YearsMale64Phase 1Australia
248NCT03394131
(ClinicalTrials.gov)
July 1, 201725/12/2017?Efficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis PatientsTreatment of Carpal Tunnel in Rheumatoid ArthritisTreatment Resistant Carpal Tunnel in RA PatientsDrug: Hylase;Drug: Insulin;Other: salineAssiut UniversityNULLUnknown status20 Years80 YearsAll90N/AEgypt
249NCT03278470
(ClinicalTrials.gov)
June 26, 20177/9/2017A Single Ascending Dose Clinical Trial to Find the Maximum Tolerable Dose of HL237 in Healthy Male SubjectA Dose Block-randomized, Double Blinded, Placebo Controlled, Dose-escalation Clinical Trial to Find the Maximum Tolerable Dose After Single Oral Dose of HL237 in Healthy Male SubjectRheumatoid ArthritisDrug: HL237;Drug: Placebo Oral TabletHanlim Pharm. Co., Ltd.NULLCompleted20 Years45 YearsMale57Phase 1Korea, Republic of
250NCT03239080
(ClinicalTrials.gov)
June 19, 20171/8/2017Effect of Denosumab in Erosion Healing in RAEffect of RANKL Inhibition on Healing of Bone Erosion in Rheumatoid Arthritis Using HR-pQCTRheumatoid ArthritisDrug: Denosumab;Other: PlaceboChinese University of Hong KongNULLCompleted18 YearsN/AAll110Phase 2China
251NCT03139136
(ClinicalTrials.gov)
May 30, 201726/4/2017Safety, Tolerability and Efficacy of MBS2320 in Patients With Rheumatoid ArthritisA 12-Week, Double-Blind, Placebo-Controlled, Phase 2a Study to Investigate the Safety, Tolerability and Efficacy of MBS2320 in Patients With Active Rheumatoid Arthritis Receiving MethotrexateRheumatoid ArthritisDrug: MBS2320;Drug: PlaceboModern Biosciences plcNULLCompleted18 Years75 YearsAll121Phase 2Georgia;Moldova, Republic of;Romania
252NCT03193957
(ClinicalTrials.gov)
May 15, 201719/6/2017An Multicentre Clinical Study to Evaluate the Usability and Safety of the Autoinjector and Pre-filled Syringe of SB4 in Subjects With Rheumatoid ArthritisAn Open-label, Single-arm, Multicentre Clinical Study to Evaluate the Usability and Safety of the Autoinjector and Pre-filled Syringe of SB4 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: Etanercept;Device: AutoinjectorSamsung Bioepis Co., Ltd.NULLCompleted18 Years55 YearsAll50Phase 2Poland
253NCT03131973
(ClinicalTrials.gov)
May 13, 201725/4/2017Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and PravastatinEffects of Concomitant Administration of BMS-986195 on the Single-dose Pharmacokinetics of Methotrexate and Probe Substrates for Cytochrome P450 1A2, 2C8, 2C9, 2C19, 3A4, Organic Anion Transporter Polypeptide 1B1 and P-glycoprotein in Healthy ParticipantsRheumatoid ArthritisDrug: BMS-986195;Drug: Methotrexate;Drug: Leucovorin;Drug: Caffeine;Drug: Montelukast;Drug: Flurbiprofen;Drug: Omeprazole;Drug: Midazolam;Drug: Digoxin;Drug: PravastatinBristol-Myers SquibbNULLCompleted18 Years50 YearsAll26Phase 1United States
254NCT03241108
(ClinicalTrials.gov)
May 10, 201726/6/2017Study of an Anti-TLR4 mAb in Rheumatoid ArthritisRandomized, Placebo-Controlled, Double Blind, Multicenter Phase 2 Study to Explore Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Intravenous Multiple Infusions of NI-0101, an Anti-Toll Like Receptor 4 Monoclonal Antibody in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: NI-0101;Other: PlaceboNovImmune SANULLCompleted18 YearsN/AAll90Phase 2Bosnia and Herzegovina;Bulgaria;Georgia;Hungary;Moldova, Republic of;Poland;Serbia
255NCT02808871
(ClinicalTrials.gov)
April 7, 201720/3/2016Phase ll Study of Pirfenidone in Patients With RAILD (TRAIL1)Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients With Rheumatoid Arthritis Interstitial Lung Disease (TRAIL1)Rheumatoid Arthritis Interstitial Lung DiseaseDrug: Pirfenidone;Drug: PlaceboBrigham and Women's HospitalNULLCompleted18 Years85 YearsAll123Phase 2United States;Australia;Canada;United Kingdom
256NCT03275025
(ClinicalTrials.gov)
April 1, 201728/8/2017A Phase 2 Study to Evaluate the Safety and Efficacy of YRA-1909 in Patients With Rheumatoid ArthritisA Multicenter, Randomized, Double-blind, Placebo-controlled, Therapeutic Exploratory, Phase II Clinical Trial for the Efficacy Investigation and Safety Evaluation of YRA-1909 in Patients With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate (MTX) and Who Have an Inadequate Response to MTX (MTX-IR)Rheumatoid ArthritisDrug: YRA-1909 low dose;Drug: YRA-1909 mid dose;Drug: YRA-1909 high dose;Drug: PlaceboYungjin Pharm. Co., Ltd.NULLCompleted19 Years80 YearsAll116Phase 2Korea, Republic of
257NCT02908490
(ClinicalTrials.gov)
April 1, 20178/7/2016Does Sildenafil Improve Endothelial Dysfunction in Rheumatoid Arthritis?Does Sildenafil Improve Endothelial Dysfunction in Rheumatoid Arthritis?Arthritis, Rheumatoid;AtherosclerosisDrug: Sildenafil;Other: PlaceboKimberly LiangNULLCompleted18 YearsN/AAll26Phase 2United States
258NCT03291457
(ClinicalTrials.gov)
March 30, 201720/9/2017A Study to Evaluate the Use of Glucocorticoids in Combination With Tocilizumab in Daily Clinical PracticeA Prospective Non-Interventional Study to Evaluate the Use of Glucocorticoids in Combination With Tocilizumab in Daily Clinical PracticeRheumatoid ArthritisDrug: Tocilizumab;Drug: Glucocorticoid AgentHoffmann-La RocheNULLCompleted18 YearsN/AAll101Belgium
259NCT03178955
(ClinicalTrials.gov)
March 27, 20172/6/2017Circadian RA Study in Rheumatoid Arthritis SubjectsThe Effects of Biologic Therapy With Disease Activity and Circadian RhythmRheumatoid ArthritisDrug: EtanerceptUniversity of California, DavisNULLWithdrawn18 Years80 YearsAll0United States
260NCT03348046
(ClinicalTrials.gov)
March 23, 201716/11/2017Safety Study of Remsima® (Infliximab) in Rheumatoid Arthritis Patients in JordanPost-Authorization Safety Study of Remsima® (Infliximab) in Rheumatoid Arthritis Patients in JordanRheumatoid ArthritisDrug: Biosimilar InfliximabHikma Pharmaceuticals LLCSyneos HealthCompleted18 YearsN/AAll22Jordan
261NCT03755258
(ClinicalTrials.gov)
March 16, 201721/11/2018Trial of Ginsenoside Compound K (GCK) Tablet in Patients With Rheumatoid ArthritisA Phase Ib Study to Evaluate the Safety, Efficacy and Pharmacokinetics of GCK in Rheumatoid Arthritis PatientsEarly Rheumatoid ArthritisDrug: GCK 100 mg + Placebo 200 mg;Drug: GCK 200 mg + Placebo 100 mg;Drug: GCK 300 mg;Drug: Placebo 300mgZhejiang Hisun Pharmaceutical Co. Ltd.NULLUnknown status18 Years65 YearsAll128Phase 1China
262NCT03082573
(ClinicalTrials.gov)
March 3, 201713/3/2017Efficacy, Radiographic and Laboratory Changes in Refractory Rheumatoid Arthritis Patients Treated With H.P. Acthar GelOpen-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Were Treated With H.P. Acthar Gel After an Incomplete Response to Combinations of DMARDs and Biologic DMRADsRheumatoid ArthritisDrug: H.P. Acthar gelIraj Sabahi Research Inc.MallinckrodtRecruiting21 YearsN/AAll30Phase 4United States
263NCT03025308
(ClinicalTrials.gov)
February 28, 201717/1/2017Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Adults With Rheumatoid ArthritisA Multicenter, Open-label, Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: Filgotinib;Drug: Placebo to match filgotinibGalapagos NVGilead SciencesActive, not recruiting18 YearsN/AAll2731Phase 3United States;Argentina;Australia;Belgium;Bulgaria;Canada;Chile;Czechia;France;Germany;Hong Kong;Hungary;India;Ireland;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;New Zealand;Poland;Romania;Russian Federation;Serbia;Slovakia;South Africa;Spain;Taiwan;Thailand;Ukraine;United Kingdom;Netherlands
264NCT03667131
(ClinicalTrials.gov)
February 13, 201710/9/2018Enalapril Maleate on Arterial Stiffness in Rheumatoid Arthritis.Effect of Prophylactic Treatment With Enalapril Maleate on Arterial Stiffness in Rheumatoid Arthritis Patients.Rheumatoid ArthritisDrug: Enalapril Maleate;Drug: PlaceboUniversity of GuadalajaraNULLCompleted18 Years80 YearsFemale59Phase 2Mexico
265NCT03052322
(ClinicalTrials.gov)
January 31, 201729/1/2017MSB11022 in Moderate to Severe Rheumatoid ArthritisA Multicenter, Randomized, Double-blind, Phase III Trial to Evaluate the Safety, Immunogenicity, and Efficacy of MSB11022 Compared With Humira® in Patients With Moderately to Severely Active Rheumatoid ArthritisModerate to Severe Rheumatoid ArthritisDrug: MSB11022;Drug: EU-HumiraFresenius Kabi SwissBioSim GmbHNULLCompleted18 YearsN/AAll288Phase 3Bulgaria;Czechia;Germany;Hungary;Poland;United Kingdom;Czech Republic
266NCT02997605
(ClinicalTrials.gov)
January 31, 201715/12/2016Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis PatientsComparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients in Low Disease Activity or Remission.RheumatoId ArthritisDrug: GlucoCorticoidUniversity Hospital, ToulouseNULLCompleted18 YearsN/AAll102Phase 4France
267NCT03028467
(ClinicalTrials.gov)
January 24, 201710/1/2017Evaluation of Pharmacokinetics and Safety of GSK3196165 in Combination With Methotrexate in Japanese Subjects With Rheumatoid ArthritisA Phase 1/2, Double-Blind, Placebo-Controlled Study of the Pharmacokinetics, Safety and Tolerability of GSK3196165 in Combination With Methotrexate Therapy, in Japanese Subjects With Active Moderate-Severe Rheumatoid Arthritis Despite Treatment With MethotrexateArthritis, RheumatoidDrug: GSK3196165 Dose 1;Drug: GSK3196165 Dose 2;Drug: GSK3196165 Dose 3;Drug: Methotrexate;Drug: Placebo;Drug: Folic acidGlaxoSmithKlineNULLCompleted20 YearsN/AAll15Phase 1/Phase 2Japan
268NCT03085940
(ClinicalTrials.gov)
January 20, 20177/2/2017Role of Hydroxychloroquine to Improve Endothelial Dysfunction in Patients With Rheumatoid ArthritisRole of Hydroxychloroquine to Improve Endothelial Dysfunction in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Hydroxychloroquine;Drug: PlaceboIndonesia UniversityNULLCompleted18 YearsN/AAll37N/AIndonesia
269NCT02990806
(ClinicalTrials.gov)
January 19, 201721/11/2016A Phase 3 Study of NI-071 in Participants With Rheumatoid Arthritis (RADIANCE)A Randomized, Double-Blind, Multicenter, 3 Stage, Efficacy and Safety Study of NI-071 and US-Licensed Remicade® (Infliximab) for the Treatment of Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: NI-071;Drug: RemicadeNichi-Iko Pharmaceutical Co., Ltd.NULLCompleted18 Years75 YearsAll683Phase 3United States;Czechia;Poland;Puerto Rico;Russian Federation;Spain;Ukraine;United Kingdom
270NCT03112213
(ClinicalTrials.gov)
January 12, 201710/4/2017Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) TreatmentCONIFER (Characterization of NSAID Intake for Established Rheumatoid Arthritis)Rheumatoid ArthritisDrug: Tocilizumab;Drug: NSAIDsHoffmann-La RocheNULLCompleted18 YearsN/AAll135Germany
271NCT02760433
(ClinicalTrials.gov)
January 9, 201729/4/2016Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Have Active DiseaseA Randomized, Double-blind, Parallel-group, Placebo-controlled, Multicenter Phase III Study of the Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Tumor Necrosis Factor Alpha (TNF-a) Inhibitor TherapyRheumatoid ArthritisDrug: Olokizumab q4w;Drug: Olokizumab q2w;Drug: Placebo q2wR-PharmQuintiles, Inc.;OCT Clinical Trials;Mene ResearchActive, not recruiting18 YearsN/AAll350Phase 3United States;Argentina;Brazil;Colombia;Czechia;Germany;Hungary;Korea, Republic of;Mexico;Poland;Russian Federation;Czech Republic;Turkey
272NCT02865434
(ClinicalTrials.gov)
January 20175/8/2016Evaluating Safety of Escalating Doses of Tilmanocept by IV Injection and SPECT Imaging in Subjects With and Without RAAn Evaluation of the Safety of Escalating Doses of Tc 99m Tilmanocept by Intravenous (IV) Injection and Skeletal Joint Imaging With SPECT in Subjects With Active Rheumatoid Arthritis (RA) and Healthy ControlsArthritis, RheumatoidDrug: Tc99m-tilmanocept;Procedure: SPECT Imaging (60 Minutes post-injection);Procedure: SPECT Imaging (180 Minutes post-injection);Procedure: Whole body planar SPECT imaging (15 Minutes post-injection);Procedure: Whole body planar SPECT imaging (60 Minutes post-injection);Procedure: Whole body planar SPECT imaging (180 Minutes post-injection);Procedure: Whole body planar SPECT imaging (18-20 Hours post-injection);Procedure: Blood Collection for PK Testing (15 Mins Before Injection);Procedure: Blood Collection for PK Testing (after injection);Procedure: Blood Collection for PK Testing (15 minutes post injection);Procedure: Blood Collection for PK Testing (60 minutes post injection);Procedure: Blood Collection for PK Testing (180 minutes post injection);Procedure: Blood Collection for PK Testing (18-20 hours post injection);Procedure: Planar Image with both Hands in Field of ViewNavidea BiopharmaceuticalsNULLCompleted18 YearsN/AAll39Phase 1/Phase 2United States
273NCT02965599
(ClinicalTrials.gov)
December 27, 201614/11/2016Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK3117391 in Subjects With Rheumatoid ArthritisA Randomised, Multi-center, Double Blind (Sponsor Open), Placebo-controlled Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK3117391 in Subjects With Severe, Active Rheumatoid ArthritisArthritis, RheumatoidDrug: GSK3117391;Drug: PlaceboGlaxoSmithKlineNULLTerminated18 YearsN/AAll3Phase 2Poland;Romania;Mexico
274NCT03001219
(ClinicalTrials.gov)
December 22, 201620/12/2016A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha TherapyA Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase II Study to Evaluate The Safety and Efficacy of RO7123520 as Adjunct Treatment in Patients With Moderately to Severely Active Rheumatoid Arthritis and an Inadequate Response to TNF-alpha InhibitorsRheumatoid ArthritisDrug: Anti-TNF-alpha;Drug: Methotrexate;Drug: Placebo;Drug: RO7123520Hoffmann-La RocheNULLTerminated18 YearsN/AAll109Phase 2United States;Argentina;Austria;Colombia;Germany;Guatemala;Italy;Mexico;Peru;Spain;United Kingdom;Czech Republic;Czechia;Poland
275NCT02969044
(ClinicalTrials.gov)
December 20, 201617/11/2016Study To Assess The Efficacy And Safety Of Pf-06651600 In Subjects With Rheumatoid Arthritis With An Inadequate Response To MethotrexateA Phase 2a, Randomized, Double-blind, Parallel Group, Placebo-controlled, Multi-center Study To Assess The Efficacy And Safety Profile Of Pf-06651600 In Subjects With Moderate To Severe Active Rheumatoid Arthritis With An Inadequate Response To MethotrexateRheumatoid ArthritisDrug: Placebo;Drug: PF-06651600PfizerNULLCompleted18 Years75 YearsAll70Phase 2United States;Bulgaria;Czechia;Georgia;Germany;Hungary;Poland;Serbia;Slovakia
276NCT02862574
(ClinicalTrials.gov)
December 15, 20168/8/2016Andecaliximab as Add-On Therapy to a Tumor Necrosis Factor Inhibitor and Methotrexate Regimen in Adults With Moderately to Severely Active Rheumatoid ArthritisEvaluation of the Efficacy and Safety of GS-5745 as Add-On Therapy to a Tumor Necrosis Factor Inhibitor and Methotrexate Regimen in Subjects With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: Andecaliximab;Drug: Placebo;Drug: Methotrexate;Drug: TNF InhibitorGilead SciencesNULLTerminated18 Years80 YearsAll15Phase 2United States;Australia;Hungary;Taiwan
277NCT02982083
(ClinicalTrials.gov)
December 20161/12/2016Clinical Trial on the Efficacy of Raloxifene on Disease Activity in Rheumatoid ArthritisClinical Trial on the Efficacy of Raloxifene on Disease Activity and Glucocorticoid-induced Osteoporosis in Postmenopausal Women With Rheumatoid ArthritisRheumatoid ArthritisDrug: Raloxifene hydrochloride;Drug: Placebo Oral TabletSara Saeidi ShahriNULLNot yet recruiting50 YearsN/AFemale40N/ANULL
278NCT02983227
(ClinicalTrials.gov)
November 30, 201629/11/2016A Study to Evaluate the Long-Term Safety and Efficacy of GDC-0853 in Participants With Moderate to Severe Rheumatoid Arthritis Enrolled in Study GA29350A Phase II Open-Label Extension Study of Patients Previously Enrolled in Study GA29350 to Evaluate the Long-Term Safety and Efficacy of GDC-0853 in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: GDC-0853Genentech, Inc.NULLCompleted18 Years76 YearsAll496Phase 2United States;Argentina;Brazil;Bulgaria;Colombia;Mexico;Poland;Russian Federation;Serbia;Ukraine;Chile;Korea, Republic of
279NCT02986139
(ClinicalTrials.gov)
November 29, 20162/11/2016Study to Assess the Injection Site Pain Associated With a New Etanercept Formulation in Adults With Rheumatoid Arthritis or Psoriatic ArthritisA Multicenter, Randomized, Double-blind, Crossover Study to Assess the Injection Site Pain Associated With a Modified Etanercept Formulation in Adult Subjects With Either Rheumatoid Arthritis or Psoriatic ArthritisArthritis, Rheumatoid; Arthritis, PsoriaticDrug: Commercial Formulation Etanercept;Drug: New Formulation EtanerceptAmgenNULLCompleted18 YearsN/AAll111Phase 3United States;Puerto Rico
280NCT02960490
(ClinicalTrials.gov)
November 26, 20163/11/2016A Phase 2 Study of E6011 in Subjects With Rheumatoid Arthritis Inadequately Responding to BiologicsA Phase 2 Study of E6011 in Subjects With Rheumatoid Arthritis Inadequately Responding to BiologicsRheumatoid ArthritisDrug: E6011;Drug: PlaceboEisai Co., Ltd.NULLCompleted18 Years75 YearsAll64Phase 2Japan
281NCT02874092
(ClinicalTrials.gov)
November 15, 201617/8/2016Ticagrelor in Methotrexate-Resistant Rheumatoid ArthritisTicagrelor in Methotrexate-Resistant Rheumatoid ArthritisRheumatoid ArthritisDrug: Ticagrelor;Drug: MTX therapyNYU Langone HealthNULLCompleted18 YearsN/AAll9Phase 4United States
282NCT02996500
(ClinicalTrials.gov)
November 10, 201613/10/2016Safety and Efficacy of Pf-06650833 In Subjects With Rheumatoid Arthritis, With An Inadequate Response To MethotrexateA 12 WEEK RANDOMIZED, DOUBLE-BLIND, DOUBLE DUMMY, PARALLEL GROUP, ACTIVE AND PLACEBO-CONTROLLED, MULTICENTER STUDY TO ASSESS THE EFFICACY AND SAFETY PROFILE OF PF-06650833 IN SUBJECTS WITH ACTIVE RHEUMATOID ARTHRITIS WITH AN INADEQUATE RESPONSE TO METHOTREXATERheumatoid ArthritisDrug: PF-06650833;Drug: Placebo;Drug: TofacitinibPfizerNULLCompleted18 Years75 YearsAll269Phase 2United States;Australia;Bosnia and Herzegovina;Bulgaria;Croatia;Czechia;Georgia;Germany;Hungary;Korea, Republic of;Mexico;Poland;Romania;Russian Federation;Serbia;Slovakia;Spain;Taiwan;Ukraine
283NCT02919761
(ClinicalTrials.gov)
November 7, 201626/9/2016Safety and Effectiveness of Acthar Gel in Participants With Rheumatoid ArthritisA Multicenter, 2 Part Study to Assess the Efficacy and Safety of Acthar Gel in Subjects With Rheumatoid Arthritis With Persistently Active Disease Despite Dual-DMARD TreatmentArthritis, RheumatoidDrug: Acthar Gel;Drug: PlaceboMallinckrodtNULLCompleted18 YearsN/AAll259Phase 4United States;Argentina;Mexico;Peru;Puerto Rico;Colombia
284NCT02960438
(ClinicalTrials.gov)
November 2, 20163/11/2016A Dose Response Study of E6011 in Subjects With Rheumatoid Arthritis Inadequately Responding to MethotrexateA Dose Response Study of E6011 in Subjects With Rheumatoid Arthritis Inadequately Responding to MethotrexateRheumatoid ArthritisDrug: E6011;Drug: PlaceboEisai Co., Ltd.NULLCompleted18 Years75 YearsAll190Phase 2Japan
285NCT03061838
(ClinicalTrials.gov)
October 27, 201620/2/2017Safety, Tolerability, PK and PD of Biosimilar Drug Ritumax® Compared to Original Drug MabThera®Multicenter Double-blind Randomized Clinical Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Biosimilar Drug Ritumax® Compared to Original Drug MabThera® in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: MabThera®;Drug: Ritumax®Biointegrator LLCNULLTerminated18 YearsN/AAll8Phase 1Russian Federation
286NCT02858492
(ClinicalTrials.gov)
October 17, 201620/7/2016Safety and Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Efficacy of Repeat Doses of GSK2982772 in Subjects With Moderate to Severe Rheumatoid Arthritis (RA)A Multicenter, Randomized, Double-blind (Sponsor-unblinded), Placebo-controlled Study to Investigate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2982772 in Subjects With Moderate to Severe Rheumatoid ArthritisArthritis, RheumatoidDrug: GSK2982772 60 mg;Drug: PlaceboGlaxoSmithKlineNULLCompleted18 Years75 YearsAll52Phase 2Germany;Italy;Poland;Russian Federation;Spain;United Kingdom
287NCT03403140
(ClinicalTrials.gov)
October 6, 201630/11/2017Long Term Efficacy, Safety and Immunogenicity of Enerceptan in Rheumatoid Arthritis ( GEMENE002 )Multicenter Extension Study To 104 Weeks To Asses The Efficacy, Safety And Immunogenicity Of Enerceptan® In Combination With Methotrexate For The Treatment Of Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: EtanerceptGema Biotech S.A.QUID Quality in Drugs and Devices Latin American Consulting SRLUnknown status19 Years99 YearsAll141Phase 3Argentina
288NCT02805010
(ClinicalTrials.gov)
October 201612/6/2016Pharmacokinetics, Safety and Tolerability Study of Single Dose of Abatacept 125mg Administered SubcutaneouslyA Randomized, Double-blind, Placebo-controlled Study to Assess the Pharmacokinetics, Safety and Tolerability of Single Dose of Abatacept 125mg Administered Subcutaneously in Chinese Healthy SubjectsRheumatoid Arthritis (RA)Drug: Abatacept;Other: PlaceboJiangsu Simcere Pharmaceutical Co., Ltd.Bristol-Myers SquibbActive, not recruiting18 Years45 YearsBoth22Phase 1NULL
289NCT02037737
(ClinicalTrials.gov)
September 30, 201621/11/2013Impact and Use of Abatacept IV for Rheumatoid Arthritis in Real Life SettingImpact and Use of Abatacept IV for Rheumatoid Arthritis in Real Life Setting in Patients With Inadequate Response to One or Several Conventional DMARDs Including Methotrexate in France. A Database Analysis Based on the ACTION StudyRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll153NULL
290NCT02885181
(ClinicalTrials.gov)
September 21, 201626/8/2016Safety, Tolerability, and Efficacy of GS-9876 in Participants With Active Rheumatoid Arthritis on Background Therapy With MethotrexateA Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 2 Proof-of-Concept Study to Evaluate Safety, Tolerability, and Efficacy of GS-9876 in Subjects With Active Rheumatoid Arthritis on Background Therapy With MethotrexateRheumatoid ArthritisDrug: GS-9876;Drug: Filgotinib;Drug: GS-9876 placebo;Drug: Filgotinib placebo;Drug: MethotrexateGilead SciencesNULLCompleted18 Years75 YearsAll83Phase 2United States;Bulgaria;Czechia;Georgia;Moldova, Republic of;Poland;Ukraine;Czech Republic;Hungary
291NCT02884635
(ClinicalTrials.gov)
September 16, 201626/8/2016A Study to Evaluate the Efficacy and Safety of ASP1707 in Postmenopausal Female Patients With Rheumatoid Arthritis Taking MethotrexatePhase IIa Study of ASP1707 A Randomized, Placebo-Controlled, Double-Blind, Parallel Group Phase 2a Study of ASP1707 in Postmenopausal Female Patients With Rheumatoid Arthritis (RA) Taking Methotrexate (MTX)Rheumatoid ArthritisDrug: ASP1707;Drug: Placebo;Drug: MethotrexateAstellas Pharma IncNULLCompletedN/AN/AFemale72Phase 2Japan
292NCT02919475
(ClinicalTrials.gov)
September 14, 201627/9/2016Study to Evaluate Efficacy, Safety and Tolerability of JTE-051 in Subjects With Active Rheumatoid ArthritisA Multicenter, Randomized, Double-blind, PlacebO-controlled, Parallel-group Study to EValuate the Efficacy and Safety of JTE-051 Administered for 12 Weeks to Subjects With Active Rheumatoid Arthritis (MOVE-RA)Rheumatoid ArthritisDrug: JTE-051;Drug: PlaceboAkros Pharma Inc.NULLCompleted18 Years75 YearsAll260Phase 2United States;Argentina;Bulgaria;Colombia;Mexico;Peru;Poland;Romania;Russian Federation;Ukraine
293NCT02833350
(ClinicalTrials.gov)
September 9, 201612/7/2016Safety and Efficacy Study of GDC-0853 Compared With Placebo and Adalimumab in Participants With Rheumatoid Arthritis (RA)A Two-Cohort Randomized Phase II, Double-Blind, Parallel Group Study in Patients With Active Rheumatoid Arthritis Evaluating the Efficacy and Safety of GDC-0853 Compared With Placebo and Adalimumab in Patients With an Inadequate Response to Previous Methotrexate Therapy (Cohort 1) and Compared With Placebo in Patients With an Inadequate Response or Intolerance to Previous TNF Therapy (Cohort 2)Rheumatoid ArthritisDrug: GDC-0853;Drug: Adalimumab;Drug: Folic Acid;Drug: MTX;Drug: PlaceboGenentech, Inc.NULLCompleted18 Years75 YearsAll578Phase 2United States;Argentina;Brazil;Bulgaria;Colombia;Korea, Republic of;Mexico;Poland;Russian Federation;Serbia;Ukraine;Chile
294NCT02831855
(ClinicalTrials.gov)
September 1, 201611/7/2016Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid ArthritisA PHASE 3B/4 RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED STUDY OF METHOTREXATE (MTX) WITHDRAWAL IN SUBJECTS WITH RHEUMATOID ARTHRITIS (RA) TREATED WITH TOFACITINIB 11MG MODIFIED RELEASE (MR) FORMULATIONRheumatoid ArthritisDrug: CP-690,550;Drug: Methotrexate;Drug: PlaceboPfizerNULLCompleted18 YearsN/AAll694Phase 4United States;Australia;Belgium;Bulgaria;Czechia;Germany;Hungary;Korea, Republic of;Mexico;Philippines;Poland;Russian Federation;Slovakia;South Africa;Spain;United Kingdom
295NCT03011281
(ClinicalTrials.gov)
September 201630/12/2016Effectiveness and Safety of Tofacitinib in Korean Patients With Rheumatoid ArthritisEffectiveness and Safety of Tofacitinib in Korean Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: TofacitinibHanyang UniversityNULLRecruiting19 YearsN/AAll378Korea, Republic of
296NCT02666443
(ClinicalTrials.gov)
September 201624/1/2016Low Dose Dexamethasone in Supraclavicular BlocksLow Dose Dexamethasone as an Adjuvant to Supraclavicular Brachial Plexus Blocks: A Prospective Randomized, Double Blinded, Control StudyRheumatoid Arthritis;Osteoarthritis;Nerve Entrapment;Ligament InjuryDrug: Control intervention (no dexamethasone);Drug: Peri-neural Dexamethasone 1 mg;Drug: Intravenous Dexamethasone 1 mgUniversity of CalgaryNULLRecruiting18 Years80 YearsBoth306N/ACanada
297NCT02897011
(ClinicalTrials.gov)
September 20167/9/20162-week dc of MTX and Influenza Vaccination in RAEffect of Two-week Discontinuation of Methotrexate on Efficacy of Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis: A Randomized Clinical TrialRheumatoid Arthritis;Influenza;MethotrexateDrug: MethotrexateSeoul National University HospitalNULLRecruiting18 Years65 YearsBoth318N/AKorea, Republic of
298NCT02930343
(ClinicalTrials.gov)
September 201613/9/2016Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate MonotherapyComparison of Sulfasalazine Versus Leflunomide Based Combination Disease Modifying Anti-rheumatic Drug Therapy (DMARD) in Patients With Rheumatoid Arthritis Failing Methotrexate Monotherapy : A Randomized Control TrialRheumatoid ArthritisDrug: Methotrexate;Drug: Leflunomide;Drug: Hydroxychloroquine;Drug: Prednisolone;Drug: Folic Acid;Drug: SulfasalazineJawaharlal Institute of Postgraduate Medical Education & ResearchNULLTerminated18 Years65 YearsAll136Phase 3India
299NCT02889796
(ClinicalTrials.gov)
August 30, 201631/8/2016Filgotinib in Combination With Methotrexate in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to MethotrexateA Randomized, Double-blind, Placebo- and Active-controlled, Multicenter, Phase 3 Study to Assess the Efficacy and Safety of Filgotinib Administered for 52 Weeks in Combination With Methotrexate to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Filgotinib;Drug: Placebo to match filgotinib;Drug: Adalimumab;Drug: Placebo to match adalimumab;Drug: MTXGilead SciencesGalapagos NVCompleted18 YearsN/AAll1759Phase 3United States;Argentina;Australia;Belgium;Bulgaria;Canada;Czechia;Germany;Hong Kong;Hungary;India;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Romania;Russian Federation;Serbia;Slovakia;South Africa;Spain;Taiwan;Thailand;Ukraine;United Kingdom;Czech Republic;France
300NCT02628028
(ClinicalTrials.gov)
August 22, 20169/12/2015A Study of LY3337641 in Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled, 2-Part Phase 2 Study to Evaluate the Safety and Efficacy of LY3337641 in Adult Subjects With Rheumatoid Arthritis: The RAjuvenate StudyRheumatoid ArthritisDrug: LY3337641;Drug: PlaceboEli Lilly and CompanyNULLTerminated18 Years65 YearsAll286Phase 2United States;Argentina;Australia;Austria;Italy;Japan;Korea, Republic of;Mexico;Poland;Puerto Rico;Slovakia;South Africa;Spain;Germany
301NCT02705989
(ClinicalTrials.gov)
August 18, 20167/3/2016Safety, Tolerability and Relative Bioavailability Study of BMS-986195 in Healthy SubjectsA Randomized, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics(PK) and Pharmacodynamics(PD), and Non-Randomized, Bioavailability(BA) Study of BMS-986195 in Healthy SubjectsRheumatoid ArthritisDrug: BMS-986195;Other: PlaceboBristol-Myers SquibbNULLCompleted18 Years55 YearsAll439Phase 1Australia
302NCT02886728
(ClinicalTrials.gov)
August 8, 201629/8/2016Filgotinib Alone and in Combination With Methotrexate (MTX) in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Are Naive to MTX TherapyA Randomized, Double-blind, Placebo- and Active-controlled, Multicenter, Phase 3 Study to Assess the Efficacy and Safety of Filgotinib Administered for 52 Weeks Alone and in Combination With Methotrexate (MTX) to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Are Naïve to MTX TherapyRheumatoid ArthritisDrug: Filgotinib;Drug: Placebo to match filgotinib;Drug: MTX;Drug: Placebo to match MTXGilead SciencesGalapagos NVCompleted18 YearsN/AAll1252Phase 3United States;Argentina;Australia;Belgium;Bulgaria;Canada;Chile;Czechia;Germany;Hong Kong;Hungary;India;Ireland;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;New Zealand;Poland;Romania;Russian Federation;Serbia;Slovakia;South Africa;Spain;Taiwan;Thailand;Ukraine;United Kingdom;Czech Republic
303NCT03775824
(ClinicalTrials.gov)
August 1, 201611/12/2018Faecal Analyses in Rheumatoid Arthritis TherapyFaecal Analyses in Rheumatoid Arthritis Therapy: An Prospective Observational Study of the Intestinal Microbiome in Patients With Rheumatoid Arthritis Receiving Immunosuppressive TherapyRheumatoid ArthritisDrug: MTX start;Drug: TNF startRegion SkaneNULLCompleted18 YearsN/AAll50NULL
304NCT02940561
(ClinicalTrials.gov)
August 201615/9/2016BE Study in Patients - Methotrexate TabletsA Multicenter, Randomized, Open Label, Two Treatment, Two Period, Two Sequence, Single-dose, Two-way, Crossover, Bioequivalence Study of Methotrexate Tablets USP, 2.5 mg Manufactured by Amneal Pharmaceuticals, With Methotrexate Tablets USP 2.5 mg Manufactured for DAVA Pharmaceuticals, Inc., Fort Lee, NJ 07024 USA in Patients With Mild to Severe Psoriasis or Rheumatoid Arthritis, Who Are Already on Established Regimens of 2.5 mg Every 12 Hours Under Fasting Condition.Psoriasis;Rheumatoid ArthritisDrug: Methotrexate - Amneal;Drug: Methotrexate - DAVAAmneal Pharmaceuticals, LLCAccutest Research Laboratories (I) Pvt. Ltd.Recruiting18 Years65 YearsBoth48Phase 1India
305NCT02892370
(ClinicalTrials.gov)
August 20162/9/2016Effect of a High-fat Meal on the Pharmacokinetics of SHR0302 and Mass Balance Study in Healthy SubjectsAn Open Label, Randomized, Two-period, Crossover Study to Assess the Effect of Food on SHR0302 and Mass Balance in Healthy VolunteersRheumatoid ArthritisDrug: SHR0302Jiangsu HengRui Medicine Co., Ltd.NULLRecruiting18 Years45 YearsMale14Phase 1China
306NCT02722694
(ClinicalTrials.gov)
August 201610/3/2016A Phase 3 Study of Abatacept in Chinese Patients With Active Rheumatoid Arthritis and Inadequate Response to MethotrexateA Phase III, Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Abatacept 125mg Administered Subcutaneously in Chinese Subjects With Active Rheumatoid Arthritis, Receiving Background Methotrexate, and Experiencing an Inadequate Response to MethotrexateRheumatoid Arthritis (RA)Drug: Subcutaneous(SC) Abatacept;Other: Placebo;Drug: MethotrexateJiangsu Simcere Pharmaceutical Co., Ltd.Bristol-Myers SquibbRecruiting18 YearsN/ABoth360Phase 3China
307NCT02784106
(ClinicalTrials.gov)
July 31, 201624/5/2016Safety and Efficacy Study of M2951 in Participants With Rheumatoid ArthritisPhase IIa Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of M2951 in Subjects With Rheumatoid Arthritis on Stable Methotrexate TherapyRheumatoid ArthritisDrug: Placebo;Drug: M2951EMD Serono Research & Development Institute, Inc.Merck KGaA, Darmstadt, GermanyCompleted18 Years75 YearsAll65Phase 2United States;Germany
308NCT02873936
(ClinicalTrials.gov)
July 27, 201617/8/2016Filgotinib Versus Placebo in Adults With Active Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Biologic Disease-modifying Anti-rheumatic Drug(s) (DMARDs) TreatmentA Randomized, Double-blind, Placebo-controlled, Multicenter, Phase 3 Study to Assess the Efficacy and Safety of Filgotinib Administered for 24 Weeks in Combination With Conventional Synthetic Disease-modifying Anti-rheumatic Drug(s) (csDMARDs) to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic DMARD(s) TreatmentRheumatoid ArthritisDrug: Filgotinib;Drug: Placebo to match filgotinib;Drug: csDMARDsGilead SciencesGalapagos NVCompleted18 YearsN/AAll449Phase 3United States;Argentina;Australia;Belgium;France;Germany;Hungary;Israel;Japan;Korea, Republic of;Mexico;Poland;Spain;Switzerland;United Kingdom;Italy;Netherlands
309NCT02867306
(ClinicalTrials.gov)
July 25, 201611/8/2016A Study to Evaluate the Pharmacokinetics of ASP1707 and Methotrexate in Patients With Rheumatoid ArthritisA Phase 1 Open-label, Single-sequence, Drug Interaction Study to Evaluate the Pharmacokinetics of ASP1707 and Methotrexate in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: ASP1707;Drug: methotrexate (MTX)Astellas Pharma Global Development, Inc.NULLCompleted18 Years65 YearsAll10Phase 1Moldova, Republic of
310NCT02683421
(ClinicalTrials.gov)
July 201622/1/2016Evaluation of SC Injected Tc 99m Tilmanocept Localization in Active RA Subjects by SPECT and SPECT/CT ImagingEvaluation of Subcutaneous (SC) Injected Tc 99m Tilmanocept Localization in Active Rheumatoid Arthritis (RA) Subjects by SPECT and SPECT/CT ImagingRheumatoid ArthritisDrug: TilmanoceptNavidea BiopharmaceuticalsNULLCompleted21 YearsN/AAll18Phase 1United States
311NCT02765074
(ClinicalTrials.gov)
June 30, 201619/4/2016Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid ArthritisFilling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of 12 Months Subcutaneous Tocilizumab in Rheumatoid Arthritis Phase IV Prospective Multicentrique StudyRheumatoid ArthritisDrug: subcutaneous tocilizumabCentre Hospitalier Régional d'OrléansRennes University HospitalRecruiting18 Years85 YearsAll60Phase 4France
312NCT02585258
(ClinicalTrials.gov)
June 30, 201620/10/2015The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis StudyThe Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study Comparing the Cost-effectiveness and Safety of Additional Low-dose Glucocorticoid in Treatment Strategies for Elderly Patients With Rheumatoid ArthritisRheumatoId ArthritisDrug: Prednisolone;Other: PlaceboVU University Medical CenterEuropean CommissionCompleted65 YearsN/AAll451Phase 4Germany;Hungary;Italy;Netherlands;Portugal;Romania;Slovakia;Finland
313NCT03106259
(ClinicalTrials.gov)
June 29, 20163/4/2017Long-term Observational Study to Evaluation the Safety of FURESTEM-RA InjObservational Study to Evaluate the Safety of FURESTEM-RA Inj. in Moderate to Severe Rheumatoid Arthritis Patients Who Participated in Phase 1 Clinical Trial of FURESTEM-RA InjRheumatoid ArthritisDrug: FURESTEM-RA Inj.Kang Stem Biotech Co., Ltd.NULLActive, not recruiting19 Years80 YearsAll9Phase 1Korea, Republic of
314NCT02799472
(ClinicalTrials.gov)
June 15, 201626/5/2016Mechanistic Study of GSK3196165 Plus Methotrexate (MTX) in Subjects With Active Rheumatoid ArthritisA Phase IIa, Double-Blind, Mechanistic Study of GSK3196165 in Combination With Methotrexate Therapy in Subjects With Active Rheumatoid Arthritis Despite Treatment With DMARDsArthritis, RheumatoidDrug: GSK3196165;Drug: Placebo;Drug: MTX;Drug: Folic (or folinic) acidGlaxoSmithKlineParexelCompleted18 YearsN/AAll39Phase 2United States;Germany;Poland
315NCT02797769
(ClinicalTrials.gov)
June 2, 20168/6/2016A Time to Cardiovascular Event Analysis Comparing Tocilizumab to Other Biologics in Patients With Rheumatoid Arthritis (RA)Risk of Cardiovascular Events in Patients Using Tocilizumab as Compared With Other Biologics in Multiple Large Healthcare DatabasesRheumatoid ArthritisDrug: Other Biologics;Drug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll48950NULL
316NCT02804204
(ClinicalTrials.gov)
June 20168/6/2016Serum Biomarkers Analysis in Patients With AR Treated With Anti-TMFAnalysis of Circulant Rheumatoid Factor, Cyclic Citrullinated Anti-peptide Anti-bodies and Albumin as a Potential Predictor in the Response to the Treatment With Anti-TNF in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Anti-TNFHospital Universitari Vall d'Hebron Research InstituteUCB PharmaUnknown status18 YearsN/AAll200Spain
317NCT02760407
(ClinicalTrials.gov)
May 24, 201629/4/2016Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo and Adalimumab, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active DiseaseA Randomized, Double-Blind, Parallel-Group, Placebo- and Active-Controlled, Multicenter Phase III Study of the Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Methotrexate TherapyRheumatoid ArthritisDrug: Olokizumab 64mg q4w;Drug: Olokizumab 64mg q2w;Drug: Adalimumab 40mg q2w;Drug: Placebo q2wR-PharmQuintiles, Inc.;OCT Clinical TrialsActive, not recruiting18 YearsN/AAll1575Phase 3United States;Argentina;Brazil;Bulgaria;Colombia;Czechia;Estonia;Germany;Hungary;Korea, Republic of;Latvia;Lithuania;Mexico;Poland;Romania;Russian Federation;Taiwan;United Kingdom;China;Czech Republic
318NCT02659150
(ClinicalTrials.gov)
May 18, 201621/12/2015Effect of Subcutaneous ACTEMRA on Inflamed Atherosclerotic Plaques in Patients With Rheumatoid ArthritisA Multicenter, Open-Label, Proof-of-Activity Study of the Effect of Subcutaneous ACTEMRA on Inflamed Atherosclerotic Plaques in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumabMassachusetts General HospitalBrigham and Women's HospitalUnknown status50 Years75 YearsFemale21Phase 4NULL
319NCT02792699
(ClinicalTrials.gov)
May 17, 201625/4/2016Study to Assess if ABP 798 is Safe & Effective in Treating Moderate to Severe Rheumatoid Arthritis (RA) Compared to RituximabA Randomized, Double-blind Study to Compare Pharmacokinetics and Pharmacodynamics, Efficacy and Safety of ABP 798 With Rituximab in Subjects With Moderate to Severe Rheumatoid ArthritisArthritis, RheumatoidDrug: ABP 798;Drug: Rituximab (US);Drug: Rituximab (EU)AmgenNULLCompleted18 Years80 YearsAll311Phase 3United States;Bulgaria;Estonia;Germany;Hungary;Poland;Canada
320NCT02780388
(ClinicalTrials.gov)
May 12, 20163/5/2016A Phase 1b Study of MEDI4920 in Participants With Adult-onset Rheumatoid ArthritisA Phase 1b Randomized, Double-blind, Placebo-controlled Multiple-ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics, and Clinical Response of MEDI4920 in Subjects With Adult-onset Rheumatoid ArthritisAdult Onset Rheumatoid ArthritisDrug: VIB4920;Other: PlaceboViela BioNULLCompleted18 Years70 YearsAll57Phase 1United States;Poland
321NCT02760316
(ClinicalTrials.gov)
May 2, 201625/4/2016A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of AZD9567.A Phase I, Randomised, Single-blind Study to Asses the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of AZD9567 in Healthy Volunteers Using Prednisolone as Positive ControlRheumatoid ArthritisDrug: AZD9567 10 mg;Drug: AZD9567 20 mg;Drug: AZD9567 40 mg;Drug: AZD9567 80 mg;Drug: Prednisolone 20 mg;Drug: AZD9567 125 mg;Drug: AZD9567 155 mg;Drug: Prednisolone 5 mg;Drug: Prednisolone 40 mgAstraZenecaNULLCompleted18 Years55 YearsAll64Phase 1Germany;United Kingdom
322NCT02665910
(ClinicalTrials.gov)
May 201624/1/2016Multiple Doses Escalation Study of SHR0302 in Rheumatoid Arthritis (RA) PatientsA Phase I, Randomized, Placebo-Controlled, Multiple Doses Escalation Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics of SHR0302 in Patients With RARheumatoid ArthritisDrug: SHR0302;Drug: SHR0302 placebo comparatorJiangsu HengRui Medicine Co., Ltd.NULLNot yet recruiting18 Years70 YearsBoth48Phase 1China
323NCT02760368
(ClinicalTrials.gov)
May 201629/4/2016Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active DiseaseA Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multicenter Phase III Study of the Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Methotrexate TherapyRheumatoid ArthritisDrug: Olokizumab;Drug: PlaceboR-Pharm International, LLCQuintiles, Inc.;OCT Clinical Trials;Mene ResearchCompleted18 YearsN/AAll428Phase 3Belarus;Bulgaria;Russian Federation;Turkey
324NCT02762123
(ClinicalTrials.gov)
May 20163/5/2016A Study to Assess the Effect of BMS-986142 on Pharmacokinetics (PK) of Probe SubstratesEffects of Concomitant Administration of BMS-986142 on the Single-dose Pharmacokinetics of Probe Substrates for CYP2C8, CYP2C9, CYP2C19, CYP3A4, and P-gp in Healthy SubjectsRheumatoid ArthritisDrug: BMS-986142 200mg;Drug: BMS Drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin);Drug: BMS-986142 350mgBristol-Myers SquibbNULLCompleted18 Years50 YearsBoth28Phase 1United States
325NCT02603146
(ClinicalTrials.gov)
April 27, 201610/11/2015Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid ArthritisStrategy to Prevent the Onset of Clinically-Apparent Rheumatoid ArthritisHealthy Participants;Rheumatoid Arthritis (RA) PreventionDrug: Hydroxychloroquine;Drug: HCQ PlaceboNational Institute of Allergy and Infectious Diseases (NIAID)Autoimmunity Centers of ExcellenceCompleted18 YearsN/AAll144Phase 2United States
326NCT02746380
(ClinicalTrials.gov)
April 13, 20165/4/2016A Study Comparing LBAL to Humira® in Subjects With Active Rheumatoid Arthritis Despite Methotrexate TherapyMulti-center (in Korea and Japan), Double-blind, Randomized, Parallel-group Study to Evaluate the Similarity of Efficacy and Safety of LBAL 40mg Subcutaneous Biweekly Injection to Humira® 40mg Subcutaneous Biweekly Injection, as Adjunctive Therapy to Methotrexate (MTX), in Patients With Active Rheumatoid Arthritis Who Had an Inadequate Response to MTXArthritis, RheumatoidDrug: LBAL;Drug: Humira®LG Life SciencesMochida Pharmaceutical Company, Ltd.Completed20 Years75 YearsAll383Phase 3Japan;Korea, Republic of
327NCT02770794
(ClinicalTrials.gov)
April 1, 201611/5/2016Optimization of Infliximab Withdrawal Strategy for Rheumatoid ArthritisMulticenter Prospective Trial to Investigate Accuracy of Ultrasound to Predict Relapse After Discontinuation of Infliximab and Efficacy/Safety of Readministration of Infliximab in Patients With Rheumatoid Arthritis in Low Disease ActivityArthritis, RheumatoidDrug: InfliximabChiba UniversityNULLCompleted18 YearsN/AAll211Phase 4Japan
328NCT02715908
(ClinicalTrials.gov)
April 201617/3/2016A Study to Evaluate the Long-term Safety and Efficacy of LBEC0101 in Subjects With Active RA Despite Methotrexate (MTX)A Extension Clinical Study to Evaluate the Long-term Safety and Efficacy of LBEC0101 When Co-administered With Methotrexate (MTX) for Additional 48 Weeks in Patients With RA Who Have Completed the Treatment Period of LG-ECCL002Rheumatoid ArthritisDrug: LBEC0101LG Life SciencesNULLCompleted20 Years75 YearsAll148Phase 3Korea, Republic of
329NCT02573012
(ClinicalTrials.gov)
March 29, 20161/10/2015Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis ParticipantsProspective, Multicentre, Placebo-controlled, Double-blind Interventional Study to Compare the Efficacy of Maintenance Treatment With Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Placebo matched to prednisone;Drug: Prednisone;Biological: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll314Phase 4France;Germany;Italy;Russian Federation;Serbia;Tunisia;Egypt;Switzerland;Turkey
330NCT02679001
(ClinicalTrials.gov)
March 24, 20168/2/2016A Comparative Study to Observe the Effect of Concomitant Use of Corticosteroid Treatment in Rheumatoid Arthritis (RA) Participants Who Are Treated With a Tumor Necrosis Factor (TNF) Inhibitor or Tocilizumab (TCZ) as Their Second Biological Treatment.A COMPARATIVE OBSERVATIONAL STUDY FOLLOWING THE USE OF CONCOMITANT CORTICOSTEROID TREATMENT IN RA PATIENTS WHO ARE TREATED WITH A TNF INHIBITOR OR TOCILIZUMAB AS THEIR SECOND BIOLOGICAL TREATMENTRheumatoid ArthritisDrug: TNF inhibitor/TCZHoffmann-La RocheNULLCompleted18 YearsN/AAll200Sweden
331NCT02720523
(ClinicalTrials.gov)
March 22, 201622/3/2016A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis (RA) Who Are on a Stable Dose of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) and Have an Inadequate Response to csDMARDsA Phase 2b/3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo in Japanese Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Are on a Stable Dose of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) and Have an Inadequate Response to csDMARDsRheumatoid ArthritisDrug: Placebo;Drug: UpadacitinibAbbVieNULLActive, not recruiting18 YearsN/AAll197Phase 2/Phase 3Japan
332NCT02706847
(ClinicalTrials.gov)
March 15, 201618/2/2016A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDsA Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo on Stable Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) in Subjects With Moderately to Severely Active Rheumatoid Arthritis With Inadequate Response or Intolerance to Biologic DMARDs (bDMARDs)Rheumatoid ArthritisDrug: Upadacitinib;Drug: PlaceboAbbVieNULLCompleted18 Years99 YearsAll499Phase 3United States;Australia;Austria;Belgium;Canada;Czechia;Estonia;Finland;France;Germany;Greece;Hungary;Ireland;Israel;Korea, Republic of;Latvia;New Zealand;Poland;Portugal;Puerto Rico;Russian Federation;Slovakia;Spain;Sweden;Switzerland;Turkey;United Kingdom;Argentina;Brazil;Bulgaria;Chile;Colombia;Czech Republic;Denmark;Hong Kong;Italy;Mexico;Norway;Slovenia
333NCT02706873
(ClinicalTrials.gov)
February 23, 201618/2/2016A Study to Compare Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have Not Previously Taken MethotrexateA Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) Once Daily Monotherapy to Methotrexate (MTX) Monotherapy in MTX-Naïve Subjects With Moderately to Severely Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Placebo to Upadacitinib;Drug: Methotrexate;Drug: Placebo to Methotrexate;Drug: UpadacitinibAbbVieNULLCompleted18 YearsN/AAll1002Phase 3United States;Argentina;Australia;Belarus;Belgium;Bosnia and Herzegovina;Brazil;Bulgaria;Canada;Chile;China;Colombia;Croatia;Czechia;Estonia;Germany;Greece;Guatemala;Hong Kong;Hungary;Ireland;Israel;Italy;Japan;Kazakhstan;Latvia;Lithuania;Mexico;New Zealand;Poland;Portugal;Puerto Rico;Romania;Russian Federation;Serbia;Slovakia;Slovenia;South Africa;Spain;Switzerland;Taiwan;Tunisia;Turkey;Ukraine;United Kingdom;Czech Republic;Finland;Malaysia;Netherlands
334NCT02698657
(ClinicalTrials.gov)
February 23, 201610/2/2016A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ASP5094 Following Multiple Intravenous Doses in Subjects With Rheumatoid Arthritis on MethotrexateA Phase 1, Randomized, Placebo-controlled, Dose Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of ASP5094 Following Multiple Intravenous Doses in Subjects With Rheumatoid Arthritis on MethotrexateRheumatoid Arthritis (RA)Drug: ASP5094;Drug: PlaceboAstellas Pharma Global Development, Inc.NULLCompleted18 Years65 YearsAll30Phase 1United States;Poland
335NCT02638948
(ClinicalTrials.gov)
February 16, 201621/12/2015Efficacy and Safety Study of BMS-986142 in Patients With Moderate to Severe Rheumatoid ArthritisPhase 2, Randomized, Multi-Center, Double-Blind, Dose-Ranging, Placebo Controlled, Adaptive Design Study to Evaluate the Efficacy and Safety/Pharmacokinetics of BMS-986142 in Subjects With Moderate to Severe Rheumatoid Arthritis With an Inadequate Response to Methotrexate With or Without TNF InhibitorsRheumatoid ArthritisDrug: BMS-986142;Drug: Placebo;Drug: MethotrexateBristol-Myers SquibbNULLCompleted18 Years120 YearsAll508Phase 2United States;Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Russian Federation;South Africa;Spain;Taiwan;Belgium
336NCT02321930
(ClinicalTrials.gov)
February 16, 201623/9/2014Musculoskeletal Ultrasound Assessment of Therapeutic Response of Tofacitinib in Rheumatoid Arthritis PatientsMusculoskeletal Ultrasound Assessment of Therapeutic Response of Tofacitinib in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: tofacitinib 5mg po bidUniversity of California, Los AngelesNULLCompleted18 YearsN/AAll37Phase 4United States
337NCT02683564
(ClinicalTrials.gov)
February 20169/2/2016BOW015 (Infliximab-EPIRUS) and Infliximab in Patients With Active Rheumatoid Arthritis: The UNIFORM StudyA Study of BOW015 (Infliximab-EPIRUS) and Infliximab in Patients With Active Rheumatoid Arthritis on Stable Methotrexate: The UNIFORM StudyRheumatoid ArthritisDrug: BOW015;Drug: RemicadeEpirus Biopharmaceuticals (Switzerland) GmbHNULLNot yet recruiting18 Years80 YearsBoth548Phase 3NULL
338NCT03355872
(ClinicalTrials.gov)
February 201622/11/2017A Randomised, Double-blind, Phase I/II Study to Evaluate the PK, PD, Safety, and Efficacy Between HLX01 and Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis and Inadequate Response to Treatment With DMARDsA Randomised, Double-blind, Phase I/II Study to Evaluate the PK, PD, Safety, and Efficacy Between HLX01 and Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis and Inadequate Response to Treatment With DMARDsRheumatoid ArthritisDrug: HLX01Shanghai Henlius BiotechNULLCompleted18 Years65 YearsAll194Phase 1/Phase 2NULL
339NCT02626026
(ClinicalTrials.gov)
January 26, 20163/12/2015Study to Evaluate Safety and Pharmacokinetics of GS-4059 (Tirabrutinib) in Healthy Volunteers and Participants With Rheumatoid Arthritis (RA)A Phase 1, Placebo-Controlled, Randomized Study Evaluating the Safety and Pharmacokinetics of GS-4059 in Healthy Volunteers and Subjects With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Tirabrutinib;Drug: PlaceboGilead SciencesOno Pharmaceutical Co. LtdCompleted18 Years65 YearsAll42Phase 1United States
340NCT02640612
(ClinicalTrials.gov)
January 22, 201618/12/2015Long-term Assessment of Safety and Efficacy of BI 695501 in Patients With Rheumatoid ArthritisLong-term Assessment of Safety, Efficacy, Pharmacokinetics and Immunogenicity of BI 695501 in Patients With Rheumatoid Arthritis (RA): an Open-label Extension Trial for Patients Who Have Completed Trial 1297.2 and Are Eligible for Long-term Treatment With AdalimumabArthritis, RheumatoidDrug: BI 695501Boehringer IngelheimNULLCompleted18 Years80 YearsAll430Phase 3United States;Bulgaria;Chile;Estonia;Germany;Hungary;Korea, Republic of;Malaysia;Poland;Russian Federation;Serbia;Spain;Thailand;Ukraine
341NCT02636907
(ClinicalTrials.gov)
January 6, 201618/12/2015Assessment of the Handling Experience With the BI 695501 Autoinjector in Patients With Rheumatoid Arthritis Followed by an Extension Phase Using BI 695501 Prefilled SyringeAssessment of Real-life Patient Handling Experience of BI 695501 Administered Subcutaneously With an Autoinjector in Patients With Rheumatoid Arthritis: an Open-label, Interventional Clinical Trial Followed by an Extension Phase of BI 695501 Administered With a Prefilled SyringeArthritis, RheumatoidDrug: BI 695501 Autoinjector;Drug: BI 695501 Prefilled syringeBoehringer IngelheimNULLCompleted18 Years80 YearsAll77Phase 2United States;Poland;Ukraine
342NCT03855007
(ClinicalTrials.gov)
January 1, 201615/2/2019The Clinical Efficacy and Safety of Iguratimod in RA and Early RA Patients for 6 Months TreatmentProspective Clinical Study to Observe the Efficacy and Safety of Iguratimod in Rheumatoid Arthritis and Early Rheumatoid Arthritis Patients for 6 Months Treatment in ChinaArthritis, RheumatoidDrug: Iguratimod;Drug: MTX;Drug: HCQ;Drug: PredQilu Hospital of Shandong UniversityNULLActive, not recruiting16 Years90 YearsAll200Phase 4China
343NCT02878161
(ClinicalTrials.gov)
January 201612/7/2016Predictability Studies on the Efficacy of TNF-a Inhibitors in Chinese RA From Real WorldScreening Protein Predictive of Response to Tumor Necrosis Factor-a Inhibitors Treatment in Chinese Rheumatoid Arthritis From Real World and Investigating Its Mechanism Through Signal PathwayRheumatoid ArthritisDrug: methotrexate(necessary);Biological: infliximab;Biological: etanercept;Biological: adalimumab;Drug: leflunomide (permitted, not necessary);Drug: NSAIDs (permitted,not necessary);Drug: Glucocorticoids (permitted,not necessary)Fen LiNULLEnrolling by invitation18 Years75 YearsBoth240Phase 4NULL
344NCT02652273
(ClinicalTrials.gov)
January 20168/1/2016Inhibition of Co-Stimulation in Rheumatoid ArthritisInhibition of Co-Stimulation in Rheumatoid ArthritisArthritis, RheumatoidDrug: AbataceptNHS Greater Glasgow and ClydeUniversity of GlasgowNot yet recruiting18 YearsN/ABoth25Phase 4United Kingdom
345NCT02644499
(ClinicalTrials.gov)
December 31, 201530/12/2015Comparison of Combination Disease Modifying Antirheumatic Drugs With Methotrexate Therapy in Early Rheumatoid ArthritisComparison of Combination Disease Modifying Antirheumatic Drugs (DMARDs) With Single Drug (Methotrexate) Therapy in Early Rheumatoid ArthritisRheumatoid ArthritisDrug: Methotrexate;Drug: Leflunomide;Drug: Hydroxychloroquine;Drug: Prednisolone;Drug: Folic AcidJawaharlal Institute of Postgraduate Medical Education & ResearchNULLCompleted18 YearsN/AAll186Phase 4India
346NCT02608112
(ClinicalTrials.gov)
December 31, 201516/11/2015Study to Describe Real World Drug Retention Rate of the Tocilizumab at One YearSubcutaneous Tocilizumab in Monotherapy or in Combination With csDMARD in Patients With Moderate to Severe Active Rheumatoid Arthritis and Followed by Hospital and Office Based Rheumatologists: Non Interventional Study to Describe Real-World Drug Retention Rate of the Biotherapy at 1 YearRheumatoid ArthritisDrug: Methotrexate;Drug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll291France
347NCT02675426
(ClinicalTrials.gov)
December 17, 201511/12/2015A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs AloneA Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo in Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Are on a Stable Dose of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) and Have an Inadequate Response to csDMARDsRheumatoid ArthritisDrug: Placebo;Drug: UpadacitinibAbbVieNULLActive, not recruiting18 Years99 YearsAll661Phase 3United States;Argentina;Australia;Austria;Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Croatia;Czechia;Estonia;Finland;France;Germany;Greece;Hong Kong;Hungary;Ireland;Italy;Kazakhstan;Korea, Republic of;Latvia;Lithuania;Mexico;New Zealand;Poland;Portugal;Puerto Rico;Romania;Russian Federation;Slovakia;South Africa;Spain;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;Belarus;Brazil;Colombia;Czech Republic;Denmark;Israel;Netherlands;Norway;Serbia;Singapore
348NCT02680067
(ClinicalTrials.gov)
December 8, 20157/12/2015NIR Fluorescence Imaging of Lymphatic Transport Using ICGNear InfraRed Fluorescence Imaging of Lymphatic Transport Using Indocyanine GreenRheumatoid ArthritisDrug: Indocyanine Green;Device: MultiSpectral Imaging SystemUniversity of RochesterNational Institutes of Health (NIH);National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed18 Years89 YearsAll23Phase 1United States
349NCT02629159
(ClinicalTrials.gov)
December 1, 201510/12/2015A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to MethotrexateA Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Are on a Stable Background of Methotrexate (MTX) and Who Have an Inadequate Response to MTX (MTX-IR)Rheumatoid ArthritisDrug: Placebo for Adalimumab;Drug: Adalimumab;Drug: Placebo for Upadacitinib;Drug: UpadacitinibAbbVieNULLActive, not recruiting18 YearsN/AAll1629Phase 3United States;Argentina;Australia;Austria;Belarus;Belgium;Bosnia and Herzegovina;Brazil;Bulgaria;Canada;Chile;Colombia;Croatia;Czechia;Denmark;Estonia;France;Germany;Greece;Hong Kong;Hungary;Ireland;Israel;Italy;Kazakhstan;Korea, Republic of;Latvia;Lithuania;Malaysia;Mexico;New Zealand;Poland;Portugal;Puerto Rico;Romania;Russian Federation;Serbia;Slovakia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;Czech Republic;Finland;Netherlands
350NCT02944799
(ClinicalTrials.gov)
December 201527/6/2016Alendronate Treatment of Osteoporosis in Rheumatoid ArthritisAlendronate Treatment of Osteoporosis in Rheumatoid Arthritis - Indication and Duration: A Randomized, Double-blind, Placebocontrolled Study to Evaluate the Effects of Discontinuation of Alendronate in Patients With Both Rheumatoid Arthritis and Low Bone MassRheumatoid Arthritis;OsteoporosisDrug: Placebo;Drug: Alendronate;Drug: Calcium;Drug: Vitamin DUniversity of AarhusNULLActive, not recruiting18 YearsN/AAll69Phase 2Denmark
351NCT02557100
(ClinicalTrials.gov)
November 19, 20154/9/2015Study to Assess Changes in the Immune Profile in Adults With Early Rheumatoid ArthritisA Randomized, Head-to-Head, Single-Blinded Study to Assess Changes in the Immune Profile in Response to Treatment With Subcutaneous Abatacept in Combination With Methotrexate Versus Subcutaneous Adalimumab in Combination With Methotrexate in Adults With Early Rheumatoid Arthritis Who Are Naive to Biologic Disease-Modifying Antirheumatic DrugsRheumatoid ArthritisDrug: Abatacept;Drug: Adalimumab;Drug: MethotrexateBristol-Myers SquibbNULLCompleted18 YearsN/AAll80Phase 4United States;Canada;Mexico;Algeria
352NCT02512575
(ClinicalTrials.gov)
November 18, 20156/7/2015A Single Ascending Dose Study To Assess The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of AZD9567.A Phase I, Randomized, Single-Blind, Placebo-Controlled Study To Assess The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Single Ascending Oral Doses Of AZD9567 In Healthy Subjects.Safety;Tolerability;Pharmacokinetics;Pharmacodynamics;Healthy Subjects;Rheumatoid ArthritisDrug: AZD9567 Monohydrat;Drug: Placebo oral suspension/ Placebo capsule;Drug: PrednisoloneAstraZenecaNULLCompleted18 Years55 YearsMale72Phase 1Germany
353NCT03172325
(ClinicalTrials.gov)
November 18, 201524/5/2017Study to Demonstrate Non-Inferior Efficacy and Safety of CinnoRA® Versus Humira® for Treatment of Active RAA Phase III, Randomized, Two-armed, Double-blind, Parallel, Active Controlled Clinical Trial to Determine the Non-inferior Efficacy and Safety of CinnoRA® (Adalimumab, CinnaGen Co.) Versus Humira® for Treatment of Active RAActive Rheumatoid ArthritisDrug: Adalimumab;Drug: Methotrexate;Drug: Folic Acid;Drug: PrednisoloneCinnagenNULLCompleted18 Years75 YearsAll136Phase 3Iran, Islamic Republic of
354NCT02780323
(ClinicalTrials.gov)
November 2, 201519/5/2016Study to Compare the Efficacy and Safety of CELBESTA® and CELEBREX® in Patients With Rheumatoid ArthritisA Multi-center, Double-blind, Active-controlled, Randomized, Parallel-group Clinical Trial to Compare the Efficacy and Safety of CELBESTA® and CELEBREX® in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: CELBESTA®;Drug: CELEBREX®;Drug: CELEBREX® placebo;Drug: CELBESTA® placeboDong-A ST Co., Ltd.NULLCompleted19 YearsN/AAll119Phase 4Korea, Republic of
355NCT02723760
(ClinicalTrials.gov)
November 201510/3/201699mTc-3PRGD2 SPECT/CT in Rheumatoid Arthritis PatientsClinical Study of 99mTc-3PRGD2 SPECT/CT in Diagnosis and Efficacy Evaluation of Rheumatoid ArthritisRheumatoid ArthritisDrug: 99mTc-3PRGD2First Affiliated Hospital of Fujian Medical UniversityNULLRecruiting20 Years70 YearsBoth40Phase 0China
356NCT02534896
(ClinicalTrials.gov)
November 201525/8/2015To Evaluate The Efficacy And Safety Of Sunpharma1505 Compared With Reference1505 In Subjects With Active Rheumatoid ArthritisTo Evaluate The Efficacy And Safety Of Sunpharma1505 Compared With Reference1505 In Subjects With Active Rheumatoid ArthritisActive Rheumatoid ArthritisDrug: Treatment I;Drug: Treatment II;Drug: Treatment IIISun Pharmaceutical Industries LimitedNULLTerminated18 Years90 YearsAll150Phase 3Belgium;Netherlands
357NCT02543931
(ClinicalTrials.gov)
November 20156/8/2015Curcuma Longa L in Rheumatoid ArthritisPhase Ib Randomized, Double-Blind, Placebo-Controlled Study of Meriva in Rheumatoid ArthritisRheumatoid ArthritisDrug: Meriva;Drug: placeboUniversity of ArizonaVanderbilt University;National Center for Complementary and Integrative Health (NCCIH);National Institutes of Health (NIH)Terminated18 YearsN/ABoth3Phase 1United States
358NCT02552940
(ClinicalTrials.gov)
October 31, 201516/9/2015An Observational Study to Evaluate the Clinical Effectiveness, Quality of Life, Safety and Tolerability of Tocilizumab (TCZ) in Patients With Rheumatoid Arthritis (RA) in Daily Clinical PracticeA PROSPECTIVE, NON-INTERVENTIONAL STUDY TO EVALUATE THE CLINICAL EFFECTIVENESS, THE CONSISTENCY OF EVALUATION SCORES, QUALITY OF LIFE, SAFETY AND TOLERABILITY OF TOCILIZUMAB SUBCUTANEOUS IN PATIENTS WITH RHEUMATOID ARTHRITIS IN DAILY CLINICAL PRACTICERheumatoid ArthritisDrug: TocilizumabHoffmann-La Rochenv Roche saCompleted18 YearsN/AAll140Belgium;Luxembourg
359NCT02534311
(ClinicalTrials.gov)
October 13, 201525/8/2015A Phase IV Study to Evaluate the Effect of Subcutaneous (SC) Tocilizumab Administered to Participants With Rheumatoid Arthritis (RA) Assessed Using Disease Activity Score (DAS28)Prospective Evaluation of Rheumatoid Arthritis Activity Using DAS28 in Patients Treated With Subcutaneously Administered Tocilizumab on Local LevelRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll60Phase 4Slovakia
360NCT02320630
(ClinicalTrials.gov)
October 201516/12/2014Combination Therapy Prevents the Relapse of RAThe Efficacy, Safety and Cost-effectiveness of Hydroxychloroquine, Sulfasalazine, Methotrexate Triple Therapy in Preventing Relapse Among Patients With Rheumatoid Arthritis Achieving Clinical Remission or Low Disease ActivityRecurrence (Disease Attribute)Drug: Entanercept;Drug: HCQ;Drug: MTXPeking University First HospitalPeking University People's Hospital;Peking University Third Hospital;Beijing Hospital;Beijing Jishuitan Hospital;Peking University Shougang Hospital;Beijing Shijitan HospitalRecruiting18 Years70 YearsAll240N/AChina
361NCT02882087
(ClinicalTrials.gov)
October 201524/8/2016A Study of the Efficacy and Safety of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Inadequate Response to TNF-a Antagonists Due to Treat Moderate and Severe Rheumatoid ArthritisA Phase II, Placebo-Controlled, Multicenter, Dynamic Randomized, Double Blind Trial of RC18, a Recombinant Human B Lymphocyte Stimulating Factor Receptor-Antibody Fusion Protein in Subjects With Inadequate Response of TNF-a Antagonists Due to Treat Moderate and Severe Rheumatoid ArthritisModerate and Severe Rheumatoid ArthritisDrug: Placebo plus MTX;Drug: RC18 160 mg plus MTXRemeGenNULLTerminated18 Years65 YearsAll60Phase 2China
362NCT02778789
(ClinicalTrials.gov)
October 201516/5/2016Comparing the Efficacy of Periarticular Bone Structure in Patients Treated With Either Tocilizumab or Tumor Necrosis Factor BlockersNon Randomized Parallel-group Clinical Study to Compare the Efficacy of Periarticular Bone Structure in Patients Treated With Either Tocilizumab or Tumor Necrosis Factor Blockers.Rheumatoid ArthritisDrug: Tocilizumab;Drug: TNF-alpha InhibitorUniversity of Erlangen-Nürnberg Medical SchoolNULLCompleted18 YearsN/AAll66Germany
363NCT02605642
(ClinicalTrials.gov)
September 10, 20152/9/2015Post-Marketing Use Of CT-P13 (Infliximab) For Standard Of Care Treatment Of Rheumatoid Diseases Who Are Naïve To Biologics Or Switched From RemicadePERSIST: PROSPECTIVE OBSERVATIONAL COHORT STUDY TO ASSESS PERSISTENCE OF CT-P13 (INFLIXIMAB) IN PATIENTS WITH RHEUMATOID DISEASES WHO ARE EITHER NAIVE TO BIOLOGICS OR SWITCHED FROM STABLE REMICADE(R) (INFLIXIMAB)Rheumatoid Diseases;Rheumatoid Arthritis;Ankylosing Spondylitis;Psoriatic ArthritisDrug: CT-P13PfizerHospira, now a wholly owned subsidiary of PfizerCompleted18 YearsN/AAll351Bulgaria;Canada;Czechia;Germany;Greece;Spain;United Kingdom;Czech Republic;France;Italy
364NCT02504268
(ClinicalTrials.gov)
September 3, 201520/7/2015Effects of Abatacept in Patients With Early Rheumatoid ArthritisA Phase 3B, Randomized, Double-Blind Clinical Trial to Evaluate the Efficacy and Safety of Abatacept SC in Combination With Methotrexate Compared to Methotrexate Monotherapy in Achieving Clinical Remission in Adults With Early Rheumatoid Arthritis Who Are Methotrexate NaiveRheumatoid ArthritisDrug: Abatacept;Drug: Methotrexate;Other: Abatacept Placebo;Other: Methotrexate PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/AAll994Phase 3United States;Argentina;Australia;Austria;Brazil;Canada;Chile;Colombia;Czechia;Finland;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Mexico;Monaco;Netherlands;Peru;Poland;Qatar;Romania;Russian Federation;Singapore;South Africa;Spain;Sweden;Taiwan;United Kingdom;Czech Republic;Puerto Rico;Saudi Arabia;United Arab Emirates
365NCT05116228
(ClinicalTrials.gov)
September 1, 201521/3/2018Non-inferiority of Reduced-dose Rituximab in Rheumatoid Arthritis in Low Disease Activity and RemissionRandomized, Prospective, Active-comparator Controlled, Patient-blinded Study to Demonstrate Non-inferiority of Reduced-dose Rituximab in Rheumatoid Arthritis Patients in Low Disease Activity and Remission - the REDOREM StudyRheumatoid Arthritis;RemissionDrug: 500mg RTX Group;Drug: 1000mg RTX GroupMedical University of ViennaNULLTerminated18 YearsN/AAll21Phase 4Austria
366NCT02748785
(ClinicalTrials.gov)
September 20158/9/2015MTX Discontinuation and Vaccine ResponseEffect of Methotrexate Discontinuation on Efficacy of Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis: A Randomized Clinical TrialArthritis, RheumatoidDrug: Methotrexate;Biological: Seasonal Influenza vaccineSeoul National University HospitalNULLCompleted18 YearsN/ABoth277Phase 4Korea, Republic of
367NCT02565810
(ClinicalTrials.gov)
September 201523/9/2015An Multicentre Clinical Study to Evaluate the Usability and Safety of the Pre-filled Pen and Pre-filled Syringe of SB5 in Subjects With Rheumatoid ArthritisAn Open-labelled, Single-arm, Multicentre Clinical Study to Evaluate the Usability and Safety of the Pre-filled Pen and Pre-filled Syringe of SB5 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: Adalimumab PFS and PenSamsung Bioepis Co., Ltd.NULLCompleted18 Years55 YearsAll49Phase 2Poland
368NCT02764515
(ClinicalTrials.gov)
September 201526/3/2016Kunxian for the Treatment of Rheumatoid ArthritisComparison of the Efficacy and Safety of Kunxian Capsule and Methotrexate for the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: Kunxian Capsule;Drug: MethotrexateChinese SLE Treatment And Research GroupCHENLIJI Pharmaceutical Company,Guangzhou Pharmaceutical Group;CHINESE RHEUMATISM DATA CENTERRecruiting40 Years70 YearsAll428Phase 4China
369NCT02535832
(ClinicalTrials.gov)
September 201524/8/2015Skeletal Muscle Dysfunction in Rheumatoid Arthritis (RA)Skeletal Muscle Dysfunction in Rheumatoid Arthritis (RA)Rheumatoid Arthritis;Insulin ResistanceDrug: Pioglitazone;Drug: PlaceboOhio State UniversityNULLRecruiting35 Years65 YearsAll36Phase 1United States
370NCT02553018
(ClinicalTrials.gov)
September 201516/9/2015Comparison of Compliance and Evolution of Functional Capacity of Patients With Rheumatoid Arthritis Treated by Methotrexate Either by Auto-injector or by Conventional Sub-cutaneous SyringeA National, Randomized, Open-label Study Comparing Compliance and Evolution of Functional Capacity of Patients With Rheumatoid Arthritis Treated With Methotrexate Administered by Auto-injector Versus Administration by Conventional Subcutaneous Injection.Arthritis, RheumatoidDrug: MethotrexateNordic Pharma SASNULLCompleted18 YearsN/AAll278Phase 3France
371NCT02717988
(ClinicalTrials.gov)
September 20154/3/2016Safety, Tolerability, and Pharmacokinetics of a Single Oral Dose of SKI-O-703 in Healthy VolunteersA Phase 1, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of a Single Oral Dose of SKI-O-703 in Healthy VolunteersRheumatoid ArthritisDrug: SKI-O-703 capsule;Drug: Placebo capsuleOscotec Inc.PPDCompleted18 Years55 YearsAll48Phase 1United States
372NCT02481180
(ClinicalTrials.gov)
July 31, 201518/6/2015Tolerance, Pharmacokinetics and Preliminary Efficacy of T0001 in RA (Rheumatoid Arthritis)An Open, Dose Escalation, Multiple Dose Study to Assess Tolerance?Pharmacokinetics?Preliminary Efficacy of T0001 in RA (Rheumatoid Arthritis)Rheumatoid ArthritisDrug: T0001;Drug: EnbrelShanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.NULLTerminated18 Years65 YearsAll36Phase 1China
373NCT02504671
(ClinicalTrials.gov)
July 23, 201520/7/2015Study to Evaluate the Efficacy and Safety of GSK3196165 Plus Methotrexate in Subjects With Active Moderate-Severe Rheumatoid ArthritisA Phase IIb, Double-Blind, Placebo-Controlled, Dose-Adaptive, Study of the Efficacy and Safety of GSK3196165 in Combination With Methotrexate Therapy, in Subjects With Active Moderate-Severe Rheumatoid Arthritis Despite Treatment With MethotrexateArthritis, RheumatoidDrug: GSK3196165;Drug: MTX;Drug: Folic acid;Drug: PlaceboGlaxoSmithKlineNULLCompleted18 YearsN/AAll222Phase 2Bulgaria;Canada;Czechia;Estonia;Germany;Hungary;Italy;Mexico;Poland;Russian Federation;South Africa;Spain;Ukraine;United Kingdom;Czech Republic
374NCT02467504
(ClinicalTrials.gov)
July 1, 20154/6/2015Low-dose Recombinant Human IL-2 for the Treatment of Rheumatoid ArthritisA Randomized, Double Blind, Placebo-controlled Pilot-study to Evaluate Efficacy and Safety of Low-dose hrIL-2 in the Treatment of Methotrexate (MTX)-Naive Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: hrIL-2 active;Drug: hrIL-2 placebo;Drug: MTX;Drug: Folic Acid;Drug: LoxoprofenPeking University People's HospitalMonash University;Beijing ShuangLu Pharmaceutical Co., Ltd.Completed18 Years70 YearsAll47Phase 2China
375NCT02598466
(ClinicalTrials.gov)
July 20154/11/2015Patient-Reported Efficacy of Subcutaneous (SC) Abatacept in Rheumatoid Arthritis (RA) - South AfricaPatient-Reported Efficacy of Subcutaneous Abatacept in Rheumatoid Arthritis: An Evaluation Of Patients In a Compassionate Use Programme in South AfricaRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbHexor, South AfricaCompleted18 YearsN/ABoth69N/ANULL
376NCT02242474
(ClinicalTrials.gov)
July 201515/9/2014Anti-TNFa Use During Elective Foot and Ankle Surgery in Patients With Rheumatoid ArthritisProspective Randomized Multicentric Trial on Anti-TNFa Treatment and Infection Risk in the Perioperative Period During Elective Foot and Ankle Surgery in Patients With Rheumatoid Arthritis.Rheumatoid ArthritisDrug: Anti-TNF suspended perioperatively;Drug: Anti-TNFa continued perioperativelyCHU de Quebec-Universite LavalNULLUnknown status18 YearsN/AAll660Phase 4Canada
377NCT02480946
(ClinicalTrials.gov)
July 201516/6/2015Safety and Tolerability Study of MBS2320 in Healthy Subjects and Subjects With Rheumatoid ArthritisA Four-Part Phase-1 Study Investigating the Tolerability, Safety and Pharmacokinetics (PK) of MBS2320 in Healthy Subjects and in Subjects With Rheumatoid Arthritis (RA) Also Treated With MethotrexateArthritis, RheumatoidDrug: MBS2320;Drug: Placebo;Drug: MethotrexateModern Biosciences plcCovanceCompleted18 Years70 YearsAll105Phase 1United Kingdom
378NCT02486939
(ClinicalTrials.gov)
July 201526/6/2015A Long Term Safety Extension Study (CHS-0214-05)An Open-Label Safety Extension Study (OLSES) Evaluating the Long Term Safety and Durability of Response of CHS-0214 (CHS-0214-05)Rheumatoid Arthritis;Plaque PsoriasisDrug: CHS-0214Coherus Biosciences, Inc.Daiichi Sankyo Co., Ltd.;ShireCompleted18 YearsN/AAll359Phase 3Japan
379NCT02405780
(ClinicalTrials.gov)
June 10, 201517/3/2015A Study to Compare FKB327 Long-term Safety, Efficacy and Immunogenicity With Humira® in Rheumatoid Arthritis PatientsAn Open-label Extension Study to Compare the Long-term Efficacy, Safety, Immunogenicity and Pharmacokinetics of FKB327 and Humira® in Patients With Rheumatoid Arthritis on Concomitant MethotrexateArthritis, RheumatoidDrug: FKB327;Drug: Humira®Fujifilm Kyowa Kirin Biologics Co., Ltd.NULLCompleted18 YearsN/AAll645Phase 3United States;Canada;Chile;Czechia;Germany;Peru;Poland;Romania;Russian Federation;Spain;Ukraine;Bulgaria;Czech Republic
380NCT02402686
(ClinicalTrials.gov)
May 20, 201525/3/2015Non-Interventional Study of Tocilizumab Subcutaneous (SC) Monotherapy in Participants With Rheumatoid Arthritis (RA)Open-Label, Multi-Center, Non-Interventional Study in Rheumatoid Arthritis (RA) Patients Treated With Tocilizumab SC Monotherapy in Daily Clinical Practice (SIMPACT)Rheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll353Hungary
381NCT02404558
(ClinicalTrials.gov)
May 201526/3/2015Single-dose Study to Describe the Safety of Sarilumab and Tocilizumab in Patients With Rheumatoid ArthritisAn Open-label, Randomized, Parallel Group, Single-dose Study to Describe the Safety of IL-6 Receptor Blockade With Sarilumab or Tocilizumab Monotherapy in Japanese Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: sarilumab SAR153191 (REGN88);Drug: tocilizumabSanofiRegeneron PharmaceuticalsCompleted20 YearsN/ABoth30Phase 1Japan
382NCT02566967
(ClinicalTrials.gov)
May 20151/10/2015An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural PerspectiveAn Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve LDA or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective When Treating to TargetRheumatoid ArthritisDrug: tofacitinibNorman B. Gaylis, MDNULLCompleted18 YearsN/AAll20Phase 3United States
383NCT02456844
(ClinicalTrials.gov)
May 201527/5/2015Study to Investigate the Effect of BMS-986142 on the Pharmacokinetics (PK) of Methotrexate and Probe Substrate Cocktail in Healthy PatientsEffects of BMS-986142 on the Single-dose Pharmacokinetics of Methotrexate and Probe Substrates Montelukast (CYP2C8), Flurbiprofen (CYP2C9), Midazolam (CYP3A4), Digoxin (P-gp), and Pravastatin (OATP1B1) in Healthy SubjectsRheumatoid ArthritisDrug: Montelukast, Flurbiprofen, Midazolam, Digoxin, Pravastatin and BMS-986142;Drug: Methotrexate, Leucovorin and BMS-986142Bristol-Myers SquibbNULLCompleted18 Years50 YearsBoth24Phase 1NULL
384NCT02460393
(ClinicalTrials.gov)
May 201518/1/2015A Trial With Humanized TNFa Monoclonal Antibody Injection by Single Dose and Dose Escalation in Healthy SubjectsA Randomized, Double Blind, Placebo Controlled Trial With Humanized TNFa Monoclonal Antibody Injection by Single Dose and Dose Escalation to Explore the Tolerance, Safety and Pharmacokinetic Characteristics in Healthy SubjectsRheumatoid ArthritisDrug: Humanized TNFa monoclonal antibody;Other: placeboShenyang Sunshine Pharmaceutical Co., LTD.NULLCompleted18 Years45 YearsAll72Phase 1China
385NCT02393378
(ClinicalTrials.gov)
April 8, 201515/3/2015Namilumab vs Adalimumab in Participants With Moderate to Severe Early Rheumatoid Arthritis Inadequately Responding to MethotrexateA 24-week Randomized, Open-Label, Parallel-Group, Active-Controlled, Exploratory, Proof-of-Mechanism Imaging Study Investigating the Efficacy of 150 mg of Namilumab Administered Subcutaneously vs Adalimumab in Patients With Moderate to Severe Early Rheumatoid Arthritis Inadequately Responding to MethotrexateRheumatoid ArthritisDrug: Namilumab;Drug: Adalimumab;Drug: Methotrexate;Drug: Folic AcidTakedaNULLTerminated18 YearsN/AAll7Phase 2Czechia;Estonia;Russian Federation;Spain;United Kingdom;Czech Republic
386NCT02499315
(ClinicalTrials.gov)
April 201510/4/2015Study to Evaluate the Safety, Tolerability, and Action of AMG 357 in Females With Rheumatoid ArthritisA Randomized, Double-blind, Placebo-controlled, Ascending Multiple-dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of AMG 357 in Female Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: AMG 357;Drug: PlaceboAmgenNULLTerminated25 Years70 YearsFemale32Phase 1United States
387NCT02433340
(ClinicalTrials.gov)
April 20152/4/2015Phase 2, Multicenter, Open-Label Extension Study With ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12-963 StudyPhase 2, Multicenter, Open-Label Extension (OLE) Study With ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12-963 Phase 2 Randomized Controlled Trial (RCT)Rheumatoid ArthritisDrug: ABT-122AbbVieNULLCompleted18 Years99 YearsAll158Phase 2Australia;Bulgaria;Canada;Czech Republic;Germany;Hungary;New Zealand;Poland;Romania;Turkey
388NCT02387762
(ClinicalTrials.gov)
April 20151/3/2015ACP-196 Versus Placebo in Subjects With Rheumatoid Arthritis on Background MethotrexateA Phase 2a, 4-Week, Double-Blind, Proof-of-Concept Efficacy and Safety Study of ACP-196 Versus Placebo in Subjects With Active Rheumatoid Arthritis on Background MethotrexateRheumatoid ArthritisDrug: acalabrutinib;Drug: PlaceboAcerta Pharma BVNULLCompleted18 Years75 YearsAll31Phase 2United States
389NCT02423538
(ClinicalTrials.gov)
April 20157/4/2015First-in-Human Single Ascending Dose of SHR0302A Phase I, Randomized, Placebo-Controlled, Single Dose Escalation Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics of SHR0302 in Healthy VolunteersRheumatoid ArthritisDrug: SHR0302;Drug: SHR0302 placebo comparatorJiangsu HengRui Medicine Co., Ltd.NULLActive, not recruiting18 Years45 YearsBoth64Phase 1China
390NCT02800811
(ClinicalTrials.gov)
April 201520/5/2016Safety, Tolerability, PK, PD, and Immunogenicity of Single and Multiple Ascending Intravenous Doses of FR104Randomized, Double-blind, Placebo-controlled, Dose-escalation Study for the Assessment of Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Single and Multiple Intravenous Doses of FR104 in Healthy SubjectsRheumatoid Arthritis;Complication of TransplantDrug: FR104;Drug: PlaceboOSE ImmunotherapeuticsNULLCompleted18 Years60 YearsBoth64Phase 1Belgium
391NCT02486302
(ClinicalTrials.gov)
March 24, 201528/6/2015A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis.A PROSPECTIVE, MULTICENTER NON-INTERVENTIONAL STUDY TO EVALUATE THE EFFICACY OF ENBREL (REGISTERED) (ETANERCEPT) OVER A PERIOD OF 12 MONTHS IN THE ROUTINE TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS, AXIAL SPONDYLOARTHRITIS, PSORIATIC ARTHRITIS, OR PLAQUE PSORIASIS WITH PARTICULAR FOCUS ON THE CLINICAL STATUS IMPROVEMENTS STILL OBSERVABLE AFTER 12 WEEKS OF TREATMENTRheumatoid Arthritis;Psoriatic Arthritis;Axial Spondyloarthritis;Plaque PsoriasisDrug: EtanerceptPfizerNULLCompleted18 YearsN/AAll1534Germany
392NCT02304354
(ClinicalTrials.gov)
March 9, 20154/11/2014Relationship Between T LYmphocytes Depletion and Clinical Response to RITUXimab in Rheumatoid Arthritis (LYRITUX)Relationship Between T LYmphocytes Depletion and Clinical Response to RITUXimab in Rheumatoid Arthritis (LYRITUX)Rheumatoid ArthritisDrug: RituximabUniversity Hospital, ToursNULLCompleted18 YearsN/AAll70Phase 3France
393NCT02620189
(ClinicalTrials.gov)
March 201512/10/2015Th17 Responses Evaluated in RA Patients on Inhibitors of TNFaA Study to Investigate the Role of IL-17 and Th17 Pathway Activation in RA Patients With Inadequate Response to Anti-TNFa TherapiesRheumatoid ArthritisDrug: Anti-TNF Biologics TherapyQueen Mary University of LondonNULLCompleted18 YearsN/AAll60United Kingdom
394NCT02353780
(ClinicalTrials.gov)
March 201530/6/2013Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or AbataceptMechanistic Studies of B- and T-Cell Function in Rheumatoid Arthritis Patients Treated With TNF Antagonists, Tocilizumab, or AbataceptRheumatoid Arthritis (RA)Drug: TNF Antagonist (enbrel, humire, remicade, cimzia, symponi);Drug: Abatacept;Drug: TocilizumabDr. Larry W. MorelandGenentech, Inc.;Bristol-Myers SquibbTerminated18 Years64 YearsAll10Phase 4United States
395NCT02638259
(ClinicalTrials.gov)
February 21, 201516/12/2015Comparative Efficacy and Safety Study of GP2015 and Enbrel® in Patients With Rheumatoid ArthritisA Randomized, Double-blind, Parallel-group Phase III Study to Demonstrate Equivalent Efficacy and to Compare Safety & Immunogenicity of GP2015 and Enbrel® (EU Authorized) in Patients With Moderate to Severe, Active Rheumatoid ArthritisRheumatoid ArthritisDrug: GP2015SandozNULLCompleted18 YearsN/AAll376Phase 3United States;Bulgaria;Czechia;Estonia;Germany;Hungary;Italy;Latvia;Lithuania;Mexico;Poland;Russian Federation;Serbia;Slovakia;Spain;United Kingdom;Czech Republic
396NCT02373813
(ClinicalTrials.gov)
February 20, 201512/1/2015Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis RemissionA Randomized Withdrawal Double-blind Study of Etanercept Monotherapy Compared to Methotrexate Monotherapy for Maintenance of Remission in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: etanercept pre-filled syringe subcutaneous injection;Drug: Oral methotrexate;Drug: Placebo for etanercept subcutaneous injection;Drug: Placebo for methotrexate;Dietary Supplement: Folic acid (non-investigational product)AmgenNULLCompleted18 YearsN/AAll371Phase 3United States;Argentina;Bulgaria;Canada;Czechia;France;Germany;Greece;Hungary;Italy;Mexico;Poland;Portugal;South Africa;Spain;Czech Republic
397NCT02633332
(ClinicalTrials.gov)
February 201530/11/2015Use of Well Known Drugs for New Destination - RA Improvement (RANT)Observational Retrospective Study About the Use of Well Known Drugs in Combination to Obtain a New Drug to Improve Quality of Life/Health in Patient With Diagnosed Rheumatoid Arthritis Not Responding to Commonly Used TreatmentsRheumatoid Arthritis;Autoimmune Diseases;Disorder of Synovium;Sjogren's Syndrome;Acute and Chronic Inflammation;Disorder of Pleura and Pleural Cavity;Felty's Syndrome;Rheumatoid NodulesDrug: Vitamin D3;Drug: Lipitor®;Drug: Acycloguanosine;Drug: Tetracycline;Drug: methotrexate;Drug: etanerceptUniversità Popolare Homo & NaturaNULLCompleted18 Years75 YearsBoth15Phase 1Italy
398NCT02357069
(ClinicalTrials.gov)
February 201529/1/2015A Study Comparing LBEC0101 to Enbrel® in Subjects With Active Rheumatoid Arthritis Despite Methotrexate TherapyMulti-center (in Korea and Japan), Double-blind, Randomized, Parallel-group Study to Evaluate Similarity of Efficacy and Safety of LBEC0101 50mg Subcutaneous Weekly Injection to Enbrel® 50mg Subcutaneous Weekly Injection, as Adjunctive Therapy to Methotrexate (MTX), in Patients With Active Rheumatoid Arthritis Who Had an Inadequate Response to MTXArthritis, RheumatoidDrug: Enbrel;Drug: LBEC0101LG Life SciencesMochida Pharmaceutical Company, Ltd.Active, not recruiting20 Years75 YearsBoth372Phase 3Japan;Korea, Republic of
399NCT02373202
(ClinicalTrials.gov)
February 201512/2/2015A Study Assessing the Safety and Efficacy of Sarilumab Added to Non-MTX DMARDs or as Monotherapy in Japanese Patients With Active Rheumatoid Arthritis (SARIL-RA-HARUKA)A Randomized, Double-blind, Multicenter Study Evaluating the Safety and Efficacy of Sarilumab Added to Non-MTX DMARDs or as Monotherapy in Japanese Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Sarilumab;Drug: Sulfasalazine;Drug: Leflunomide;Drug: Bucillamine;Drug: Tacrolimus;Drug: MizoribineSanofiRegeneron PharmaceuticalsCompleted20 YearsN/AAll91Phase 3Japan
400NCT02330445
(ClinicalTrials.gov)
February 201518/12/20146-Month Phase I/II Open Label PRTX-100 in Previous Rheumatoid Arthritis Study Participants and Sera CollectionPhase I/II Open Label Evaluation of Safety and Feasibility of 6 Months IV PRTX-100 Administrations in Previous Rheumatoid Arthritis Study Participants and Development of Immunological Samples for Assay Development From Normal VolunteersArthritis, RheumatoidDrug: PRTX-100Protalex, Inc.NULLCompleted18 YearsN/AAll13Phase 1/Phase 2United States
401NCT02332590
(ClinicalTrials.gov)
January 28, 20155/1/2015Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)A Randomized, Double-blind, Parallel-group Study Assessing the Efficacy and Safety of Sarilumab Monotherapy Versus Adalimumab Monotherapy in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Sarilumab;Drug: Adalimumab;Drug: Placebo (for sarilumab);Drug: Placebo (for adalimumab)SanofiRegeneron PharmaceuticalsCompleted18 YearsN/AAll369Phase 3United States;Chile;Czechia;Germany;Hungary;Israel;Korea, Republic of;Peru;Poland;Romania;Russian Federation;South Africa;Spain;Ukraine;United Kingdom;Czech Republic;France
402NCT02137226
(ClinicalTrials.gov)
January 26, 201512/5/2014BI 695501 Compared to Adalimumab in Patients With Active Rheumatoid ArthritisEfficacy, Safety and Immunogenicity of BI 695501 Versus Adalimumab in Patients With Active Rheumatoid Arthritis: a Randomized, Double-blind,Parallel Arm, Multiple Dose, Active Comparator TrialArthritis, RheumatoidDrug: BI 695501;Drug: US-licensed Humira®Boehringer IngelheimNULLCompleted18 Years80 YearsAll645Phase 3United States;Bulgaria;Chile;Estonia;Germany;Hungary;Korea, Republic of;Malaysia;New Zealand;Poland;Russian Federation;Serbia;Spain;Thailand;Ukraine;Argentina;Colombia;Mexico;Philippines;South Africa
403NCT02837978
(ClinicalTrials.gov)
January 201513/7/2016The Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months and Long-term TreatmentProspective Clinical Study to Observe the Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months Treatment in ChinaArthritis, RheumatoidDrug: Tacrolimus;Drug: MTXQiang ShuNULLRecruiting18 Years80 YearsAll150Phase 4China
404NCT02927535
(ClinicalTrials.gov)
January 201516/9/2016Evaluation of TNFa Blockers Monotherapy in Early Rheumatoid Arthritis in FranceRheumatoid ArthritisDrug: TNF blockers monotherapyCentre Hospitalier Universitaire de NimesPfizer;PfizerCompleted18 Years70 YearsBoth813N/ANULL
405NCT02371096
(ClinicalTrials.gov)
January 20155/2/2015Comparative Pharmacokinetic Trial of RGB-03 and MabTheraRheumatoid ArthritisDrug: MabThera (rituximab);Drug: RGB-03Gedeon Richter Plc.NULLNot yet recruiting18 Years75 YearsBothPhase 1NULL
406NCT04192617
(ClinicalTrials.gov)
December 31, 20145/12/2019A Study to Evaluate the Safety and Efficacy of SM03 in Patients With Rheumatoid Arthritis Receiving MethotrexateA Randomized,Placebo Controlled, Double-blind, Parallel Group, Phase II Study to Evaluate the Efficacy and Safety of SM03, Compared to Placebo, in Patients With Moderate-to-Severe Active Rheumatoid Arthritis Receiving MethotrexateRheumatoid ArthritisDrug: SM03;Drug: Placebo;Drug: MethotrexateSinoMab Pty LtdNULLCompleted18 Years75 YearsAll156Phase 2China
407NCT02379091
(ClinicalTrials.gov)
December 17, 201428/11/2014Dose Finding Study of Namilumab in Combination With Methotrexate in Participants With Moderate to Severe Rheumatoid Arthritis (RA)A 24-Week Randomized, Double-Blind, Placebo-Controlled, Phase 2 Dose Finding Study to Evaluate the Efficacy and Safety of 3 Doses of Namilumab (20 mg, 80 mg and 150 mg) in Combination With Methotrexate (MTX) in Subjects With Moderate to Severe Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Namilumab;Drug: Placebo;Drug: Methotrexate;Drug: Folic/folinic acidTakedaNULLCompleted18 YearsN/AAll108Phase 2Bulgaria;Czechia;Japan;Korea, Republic of;Poland;Russian Federation;Spain;United Kingdom;Argentina;Brazil;Colombia;Czech Republic;Germany;Mexico
408NCT02328027
(ClinicalTrials.gov)
December 11, 201418/12/201499mTc-rhAnnexin V-128 a Phase I/IIa Study in Patients With Rheumatoid Arthritis (RA) or Ankylosing Spondylitis (AS)A Phase I-IIa Study of Safety, Tolerance, Pharmacokinetics, Dosimetry and Benefice of Early Nuclear Medicine Imaging of 99mTc-rhAnnexin V-128 in Patients With Rheumatoid Arthritis or Ankylosing SpondylitisRheumatoid Arthritis;Ankylosing SpondylitisDrug: 99mTc-rhAnnexin V-128Advanced Accelerator ApplicationsNULLTerminated18 YearsN/AAll16Phase 1/Phase 2Switzerland
409NCT02260791
(ClinicalTrials.gov)
December 201429/7/2014A Study to Compare FKB327 Efficacy and Safety With Humira® in Rheumatoid Arthritis PatientsA Randomised, Blinded, Active-Controlled Study to Compare FKB327 Efficacy and Safety With the Comparator Humira® in Rheumatoid Arthritis Patients Inadequately Controlled on MethotrexateArthritis, RheumatoidDrug: FKB327;Drug: Humira®Fujifilm Kyowa Kirin Biologics Co., Ltd.NULLCompleted18 YearsN/AAll728Phase 3United States;Bulgaria;Canada;Chile;Czechia;Germany;Peru;Poland;Romania;Russian Federation;Spain;Ukraine;Czech Republic;Serbia
410NCT02876874
(ClinicalTrials.gov)
December 20143/2/2015Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainagethe Relationship Between the Activity of Rheumatoid Arthritis(RA) and Popliteal/Epitrochlear Lymph Node Morphology and the Drainage of Hand/Foot Superficial Lymphatic VesselsRheumatoid Arthritis;Lymph Node Mass;Lymphatic Vessel; DilatationDrug: indocyanine green(ICG)Shanghai University of Traditional Chinese MedicineNULLRecruiting18 Years65 YearsBoth21N/AChina
411NCT02281552
(ClinicalTrials.gov)
November 18, 201430/10/2014A Study To Evaluate The Safety And Efficacy Of Tofacitinib Modified Release Tablets Compared To Tofacitinib Immediate Release Tablets In Adult Patients With Rheumatoid ArthritisA Multicenter, Randomized, Double-blind, Parallel-group, Phase 3 Study To Demonstrate Non-inferiority For The Efficacy Of A Once Daily Dose Of Tofacitinib Modified Release Tablet To A Twice Daily Dose Of The Immediate Release Tablet In Adult Patients With Rheumatoid Arthritis On Background MethotrexateRheumatoid ArthritisDrug: TofacitinibPfizerNULLCompleted20 YearsN/AAll209Phase 3Japan
412NCT02551575
(ClinicalTrials.gov)
November 201426/8/2015Efficacy and Safety of Traditional Chinese Medicine (TCM) Comprehensive Therapy in Patients With Rheumatoid ArthritisEfficacy and Safety of Qingre Huoxue Comprehensive Therapy in the Treatment of Rheumatoid Arthritis (RA): A Randomized, Double-blind, Double-dummy, Multi-center TrialRheumatoid ArthritisDrug: Treatment of MTX and HCQ;Drug: Treatment of TCM;Drug: Integrative MedicineGuang'anmen Hospital of China Academy of Chinese Medical SciencesNULLActive, not recruiting18 Years65 YearsBoth468Phase 2/Phase 3China
413NCT02030028
(ClinicalTrials.gov)
November 20146/1/2014ACTH Gel Therapy in Rheumatoid ArthritisOpen Label Study to Evaluate Efficacy and Safety of Short-Term, Adjunctive Adrenocorticotropic Hormone (ACTH) Gel in Rheumatoid ArthritisRheumatoid ArthritisDrug: ACTHAR gelDana AschermanMallinckrodtCompleted18 Years100 YearsAll20N/AUnited States
414NCT02342977
(ClinicalTrials.gov)
November 201418/12/2014Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty:Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty: A Randomized Double -Blinded, Placebo-controlled Pilot Study.Osteoarthritis;Rheumatoid Arthritis;Avascular NecrosisDrug: Placebo;Drug: LacosamideIndiana University School of MedicineVA Office of Research and DevelopmentWithdrawn18 Years70 YearsBoth0Phase 2United States
415NCT02293902
(ClinicalTrials.gov)
November 201413/11/2014A Study Assessing the Efficacy and Safety of Sarilumab Added to MTX in Japanese Patients With Moderately to Severely Active Rheumatoid Arthritis (SARIL-RA-KAKEHASI)A Randomized, Double-blind, Multicenter Study With a Placebo-controlled Period Assessing the Efficacy and Safety of Sarilumab Added to Methotrexate (MTX) in Japanese Patients With Moderately to Severely Active Rheumatoid Arthritis Who Are Inadequate Responders to MTX TherapyRheumatoid ArthritisDrug: Sarilumab SAR153191 (REGN88);Other: Placebo (for sarilumab);Drug: Methotrexate;Drug: Folic acidSanofiRegeneron PharmaceuticalsCompleted20 Years75 YearsAll243Phase 3Japan
416NCT02287610
(ClinicalTrials.gov)
November 20146/11/2014A Non-Interventional Study of RAYOS in Adult Patients With Rheumatoid ArthritisA Non-Interventional Study to Evaluate the Effectiveness of Delayed-Release Prednisone (RAYOS) on Clinical Assessments and Serologic Disease Activity in Patients With Active Rheumatoid Arthritis in the Clinical Practice SettingRheumatoid ArthritisDrug: RAYOS (delayed-release prednisone)Horizon Pharma Ireland, Ltd., Dublin IrelandNULLCompleted18 YearsN/AAll75N/ANULL
417NCT02319642
(ClinicalTrials.gov)
November 201415/12/2014An Open-label Extension Study of Certolizumab Pegol in Chinese Patients With Rheumatoid Arthritis Who Enrolled in RA0044A Phase 3, Multicenter, Open-label Extension Study To Assess The Safety And Efficacy Of Certolizumab Pegol As Additional Medication To Methotrexate In Chinese Subjects With Active Rheumatoid Arthritis Who Participated In RA0044.Rheumatoid ArthritisDrug: Certolizumab PegolUCB Pharma SAParexelCompleted18 YearsN/AAll347Phase 3China
418NCT02270632
(ClinicalTrials.gov)
October 1, 201416/10/2014A Randomized, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of F8IL10 (Dekavil) in Patients With Active RA Receiving MTXA Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Study to Evaluate Safety and Clinical Efficacy of Two Different Doses of F8IL10 (Dekavil) Administered Subcutaneously to Patients With Active Rheumatoid Arthritis Receiving Methotrexate.Rheumatoid ArthritisDrug: F8IL10;Drug: MTX;Drug: PlaceboPhilogen S.p.A.NULLActive, not recruiting18 Years74 YearsAll27Phase 2Germany;Italy;Switzerland
419NCT02148640
(ClinicalTrials.gov)
October 201423/5/2014The NOR-SWITCH StudyA RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP STUDY TO EVALUATE THE SAFETY AND EFFICACY OF SWITCHING FROM INNOVATOR INFLIXIMAB TO BIOSIMILAR INFLIXIMAB COMPARED WITH CONTINUED TREATMENT WITH INNOVATOR INFLIXIMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, PSORIATIC ARTHRITIS, ULCERATIVE COLITIS, CROHN'S DISEASE AND CHRONIC PLAQUE PSORIASIS THE NOR-SWITCH STUDYRheumatoid Arthritis;Spondyloarthritis;Psoriatic Arthritis;Ulcerative Colitis;Crohn's Disease;Psoriasis ChronicDrug: Innovator infliximab;Drug: Biosimilar infliximabDiakonhjemmet HospitalSouth-Eastern Norway Regional Health AuthorityCompleted18 YearsN/AAll482Phase 4Norway
420NCT02150473
(ClinicalTrials.gov)
October 201427/2/2014The Effect of Adalimumab Plus Methotrexate (MTX) Versus Placebo Plus MTX on Cartilage in (RA) PatientsDelayed Gadolinium-enhanced Magnetic Resonance (MR) Imaging of Cartilage - A Pilot Study to Measure the Effect of Adalimumab Plus MTX Versus Placebo Plus MTX on Cartilage in Early RA PatientsRheumatoid ArthritisDrug: Adalimumab;Drug: PlaceboHeinrich-Heine University, DuesseldorfAbbottTerminated18 Years80 YearsAll21Phase 3Germany
421NCT02265705
(ClinicalTrials.gov)
October 201413/10/2014A Study of Baricitinib (LY3009104) in Participants With Rheumatoid Arthritis (RA)A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib in Patients With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate TherapyRheumatoid ArthritisDrug: Baricitinib;Drug: PlaceboEli Lilly and CompanyNULLCompleted18 YearsN/AAll290Phase 3Argentina;Brazil;China
422NCT02500498
(ClinicalTrials.gov)
October 201415/7/2015Safety Profile of Nulojix in Home Infusion SettingsSafety Profile of Nulojix in Home Infusion SettingsRheumatoid ArthritisDrug: NulojixBristol-Myers SquibbBiologicTx, LLCCompleted18 YearsN/ABoth37N/ANULL
423NCT02102594
(ClinicalTrials.gov)
October 201425/3/2014Therapy of Antibody-mediated Autoimmune Diseases by Bortezomib (TAVAB)Therapy of Antibody-mediated Autoimmune Diseases by Bortezomib (TAVAB)Myasthenia Gravis;Systemic Lupus Erythematosus;Rheumatoid ArthritisDrug: BortezomibCharite University, Berlin, GermanyProf. Dr. med. Falk Hiepe (Charité, Internal Medicine / Rheumathology);NeuroCure Clinical Research Center, Charite, BerlinTerminated18 Years75 YearsAll11Phase 2Germany
424NCT02097264
(ClinicalTrials.gov)
September 201424/3/2014A Trial Investigating the Mechanism of Action of NNC0109-0012 (Anti-IL-20 mAb) Through Synovial Biopsies in Subjects With Rheumatoid Arthritis and an Inadequate Response to MethotrexateA Randomised, Active Comparator, Double-blind, Multi Centre, Parallel, Phase 2a Trial, Investigating the Mechanism of Action, of NNC0109-0012 (Anti-IL-20 mAb) Through Synovial Biopsies in Subjects With Rheumatoid Arthritis and an Inadequate Response to MethotrexateInflammation;Rheumatoid ArthritisDrug: NNC0109-0012;Drug: Adalimumab;Drug: placeboNovo Nordisk A/SNULLWithdrawn18 Years75 YearsBoth0Phase 2Ireland;Portugal;Spain;United Kingdom
425NCT01717859
(ClinicalTrials.gov)
September 201419/10/2012Musculoskeletal Ultrasound in Predicting Early Dose Titration With TocilizumabMusculoskeletal Ultrasound in Predicting Early Dose Titration With TocilizumabRheumatoid ArthritisDrug: TocilizumabUniversity of California, Los AngelesGenentech, Inc.Completed18 YearsN/AAll74Phase 4United States
426NCT02202837
(ClinicalTrials.gov)
August 12, 201415/7/2014Study With Etanercept Focusing on Remission and Predictability of Remission in Real Life Clinical PracticeDefining Which Remission Criterion At Month 6 Predicts Remission At Month 12 In A Real Life Clinical Practice, In A Cohort Of Rheumatoid Arthritis Patients Treated With Etanercept (Enbrel (Registered))Rheumatoid ArthritisDrug: etanerceptPfizerNULLCompleted18 YearsN/AAll157Belgium
427NCT02308163
(ClinicalTrials.gov)
August 8, 20142/12/2014A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDsPhase 3 Study of ASP015K - A Randomized, Double-blind, Placebo-controlled Confirmatory Study of the Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis Who Had an Inadequate Response to DMARDsRheumatoid ArthritisDrug: Peficitinib;Drug: Placebo;Biological: EtanerceptAstellas Pharma IncNULLCompleted20 YearsN/AAll509Phase 3Japan;Korea, Republic of;Taiwan
428NCT02187055
(ClinicalTrials.gov)
August 20148/7/2014An Efficacy And Safety Study Evaluating Tofacitinib With And Without Methotrexate Compared To Adalimumab With MethotrexateA Phase 3b/4 Randomized Double Blind Study Of 5 Mg Of Tofacitinib With And Without Methotrexate In Comparison To Adalimumab With Methotrexate In Subjects With Moderately To Severely Active Rheumatoid ArthritisRhematoid ArthritisDrug: Tofacitinib with methotrexate;Drug: Tofacitinib without methotrexate;Biological: Adalimumab with methotrexatePfizerNULLCompleted18 YearsN/AAll1152Phase 4United States;Argentina;Australia;Bosnia and Herzegovina;Bulgaria;Canada;Chile;Czechia;Estonia;Israel;Korea, Republic of;Latvia;Lithuania;Mexico;Peru;Philippines;Poland;Romania;Russian Federation;South Africa;Spain;Taiwan;Thailand;Turkey;United Kingdom;Croatia;Czech Republic;France
429NCT02176876
(ClinicalTrials.gov)
August 201425/6/2014Safety, Tolerability, and Pharmacokinetics of GS-5745 in Subjects With Rheumatoid ArthritisA Phase 1b, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GS-5745 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: GS-5745;Drug: Placebo to match GS-5745Gilead SciencesNULLCompleted18 Years70 YearsBoth18Phase 1Czech Republic;Hungary
430NCT04752748
(ClinicalTrials.gov)
August 201410/2/2021Power Doppler in Hand Joints of Early RA PatientsPower Doppler in Hand Joints is a Predictor of Therapeutic Failure in Women With Early Rheumatoid Arthritis Naive for TreatmentEarly Rheumatoid ArthritisDrug: Drug protocolFederal University of São PauloNULLCompleted18 Years65 YearsFemale48NULL
431NCT02211469
(ClinicalTrials.gov)
August 20146/8/2014A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986104 in Healthy Male SubjectsA Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986104 in Healthy Male SubjectsRheumatoid ArthritisDrug: BMS-986104;Drug: PlaceboBristol-Myers SquibbNULLCompleted18 Years49 YearsMale41Phase 1United States
432NCT02264301
(ClinicalTrials.gov)
August 20143/10/2014Qingkailing Injection Versus Puerarin Injection on Withdrawal Rate of Corticosteroids in Patients With Active Rheumatoid ArthritisThe Effect of Qingkailing Injection on Corticosteroids Withdrawal Rate in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Puerarin injection 400 mg;Drug: Qingkailing injection 40 mlChengdu PLA General HospitalNULLEnrolling by invitation18 Years75 YearsAll150N/AChina
433NCT02219191
(ClinicalTrials.gov)
August 201416/7/2014Puerarin Versus Atorvastatin in Treating Metabolism Syndrome in Patients With Chronic Rheumatic DiseasesThe Effect of Puerarin Tablets in Treating Metabolism Syndrome in Patients With Chronic Rheumatic DiseasesRheumatoid ArthritisDrug: puerarin tablet 50 mg;Drug: Atorvastatin tablet 20 mgChengdu PLA General HospitalNULLActive, not recruiting18 Years75 YearsAll150N/AChina
434NCT02234960
(ClinicalTrials.gov)
August 20145/9/2014Local, Non-Interventional Study of RoActemra (Tocilizumab) in Poland (ACT-POL): First-Line Treatment in Routine Clinical Practice of Participants With Rheumatoid Arthritis (RA)TOCILIZUMAB IN FIRST LINE BIOLOGIC TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS IN ROUTINE CLINICAL PRACTICE IN POLAND - MULTICENTER, NON-INTERVENTIONAL, PROSPECTIVE, OBSERVATIONAL STUDY (ACT-POL)Rheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/ABoth102N/APoland
435NCT02219347
(ClinicalTrials.gov)
August 201415/8/2014Biomarkers of Remission in Rheumatoid Arthritis (BioRRA)Biomarkers of Remission in Rheumatoid Arthritis (BioRRA)Rheumatoid ArthritisDrug: DMARD cessationNewcastle-upon-Tyne Hospitals NHS TrustNewcastle University;Wellcome TrustCompleted18 YearsN/AAll74N/AUnited Kingdom
436NCT02305849
(ClinicalTrials.gov)
July 25, 20141/12/2014A Study to Evaluate Efficacy and Safety of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to Methotrexate (MTX) TreatmentPhase 3 Study of ASP015K - A Randomized, Double-blind, Placebo-controlled Confirmatory Study of the Efficacy and Safety of ASP015K in Patients With Rheumatoid Arthritis Who Had an Inadequate Response to MTXRheumatoid ArthritisDrug: Peficitinib;Drug: Placebo;Drug: MethotrexateAstellas Pharma IncNULLCompleted20 YearsN/AAll519Phase 3Japan
437NCT02011334
(ClinicalTrials.gov)
July 20144/12/2013A Study Assessing the Safety and Efficacy of Subcutaneous RoActemra/Actemra Alone or in Combination With Non-biologic Antirheumatics in Rhuematoid Arthritis Patients in Latin America With Inadequate Response to Non-biologic Antirheumatic Drugs.A MULTICENTER, OPEN LABEL STUDY TO EVALUATE EFFICACY AND SAFETY OF TOCILIZUMAB GIVEN SUBCUTANEOUSLY IN MONOTHERAPY AND IN COMBINATION WITH NON-BIOLOGIC DMARDS IN PATIENTS WITH MODERATE TO SEVERE ACTIVE RHEUMATOID ARTHRITIS IN LATIN AMERICARheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/ABoth285Phase 3Argentina;Brazil;Colombia;Dominican Republic;Mexico;Venezuela;Ecuador;Uruguay
438NCT02053727
(ClinicalTrials.gov)
July 20146/11/2013Abatacept vs Placebo in RA Patients With Hepatitis B on Entecavir BackgroundPilot Study to Evaluate Subcutaneous Abatacept vs Placebo in RA Patients With Hepatitis B on Entecavir Background- a Pilot, Double-blind, Placebo-controlled, Randomized, Controlled Trial.Rheumatoid Arthritis;Chronic Hepatitis BDrug: Abatacept;Drug: PlaceboUniversity of California, Los AngelesNULLWithdrawn18 YearsN/AAll0N/AUnited States
439NCT02121210
(ClinicalTrials.gov)
June 201421/4/2014To Evaluate the Immunogenicity and Safety of Sarilumab Administered as Monotherapy in Patients With Rheumatoid Arthritis (RA)An Open-label, Randomized, Parallel Group Study Assessing the Immunogenicity and Safety of Sarilumab Administered as Monotherapy in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: sarilumab SAR153191 (REGN88)SanofiRegeneron PharmaceuticalsCompleted18 YearsN/AAll132Phase 3United States;Chile;Czechia;Estonia;Hungary;Poland;Russian Federation;Czech Republic
440NCT01984268
(ClinicalTrials.gov)
June 20148/11/2013ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to MethotrexateAdenocorticotrophic Hormone for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to MethotrexateRheumatoid ArthritisDrug: ACTHARDartmouth-Hitchcock Medical CenterMallinckrodtRecruiting18 Years70 YearsBoth60Phase 2United States
441NCT02202395
(ClinicalTrials.gov)
June 201423/7/2014Hydroxytriptolide in Active Rheumatoid Arthritis Patients With an Inadequate Response to MethotrexateA Radomized, Double-blind, and Placebo-controlled Multicenter Clinical Trial of Hydroxytriptolide, in Active Rheumatoid Arthritis Patients With an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: LTS 0.25mg;Drug: LTS 0.5mg;Drug: LTS 1.0mg;Drug: PlaceboShanghai Pharmaceuticals Holding Co., LtdNULLCompleted35 Years65 YearsFemale120Phase 1/Phase 2China
442NCT02147587
(ClinicalTrials.gov)
June 201422/5/2014A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background MethotrexateA Randomized, Double-blind, Placebo-controlled, Phase 2 Study To Assess The Immune Response Following Administration Of Zoster Vaccine To Subjects With Rheumatoid Arthritis Receiving Tofacitinib (Cp-690,550) Or Placebo With Background Methotrexate TreatmentRheumatoid ArthritisDrug: Tofacitinib;Drug: PlaceboPfizerNULLCompleted50 YearsN/AAll112Phase 2United States;United Kingdom
443NCT02046616
(ClinicalTrials.gov)
May 28, 201424/1/2014A Study of Subcutaneous (SC) Tocilizumab (RoActemra/Actemra) in Participants With Active Rheumatoid Arthritis (RA) and Inadequate Response to Disease-Modifying Anti-Rheumatic Drugs (DMARDs)Tocilizumab SC in Patients With Active Rheumatoid Arthritis and Inadequate Response to DMARDs. A Single-Arm, Open-Label Study to Evaluate Safety, Tolerability and Efficacy. In a Subgroup of Patients Inflammation Will Be Measured by Ultrasound.Rheumatoid ArthritisDrug: Tocilizumab;Drug: Methotrexate;Drug: Non-Biologic DMARDsHoffmann-La RocheNULLCompleted18 YearsN/AAll133Phase 3Denmark;Finland;Norway;Sweden
444NCT02196558
(ClinicalTrials.gov)
May 26, 201416/7/2014A Study of E6011 in Japanese Subjects With Rheumatoid ArthritisA Phase 1/2 Study of Repeated Subcutaneous E6011 Administration in Japanese Subjects With Rheumatoid ArthritisArthritis, RheumatoidDrug: E6011Eisai Co., Ltd.NULLCompleted20 Years64 YearsAll53Phase 1/Phase 2Japan
445NCT02167139
(ClinicalTrials.gov)
May 201416/6/2014A Study Comparing SB5 to Humira® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate TherapyA Randomised, Double-blind, Parallel Group, Multicentre Clinical Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics and Immunogenicity of SB5 Compared to Humira® in Subjects With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: Humira (adalimumab);Drug: SB5 (proposed biosimilar to adalimumab)Samsung Bioepis Co., Ltd.NULLCompleted18 Years75 YearsAll544Phase 3Lithuania;Poland
446NCT02105129
(ClinicalTrials.gov)
May 201419/3/2014A Study of the Safety, Tolerability and Pharmacokinetics of HMPL-523A Phase I, Randomized, Double Blind, Placebo-controlled, Dose-escalating Study of the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of HMPL-523Rheumatoid Arthritis (RA)Drug: HMPL-523;Drug: PlaceboHutchison Medipharma LimitedNULLCompleted18 Years45 YearsMale118Phase 1Australia
447NCT02087696
(ClinicalTrials.gov)
May 20146/3/2014Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid ArthritisUncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis and Candidates With a Biological MonotherapyArthritis, RheumatoidDrug: TocilizumabSpanish Foundation of RheumatologyRoche Farma, S.ARecruiting18 YearsN/ABoth122Phase 4Spain
448NCT02151474
(ClinicalTrials.gov)
May 201428/5/2014INCB047986 in Rheumatoid ArthritisA Double-Blind, Placebo-Controlled Study Exploring the Safety, Tolerability, and Efficacy of a 28-Day Course of INCB047986 in Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: INCB047986;Drug: PlaceboIncyte CorporationNULLRecruiting18 YearsN/ABoth60Phase 2United States
449NCT02157012
(ClinicalTrials.gov)
May 20141/6/2014Evaluation of the Condition of Rheumatoid Arthritis After TreatmentEvaluation of the Condition After Xeljanz Treatment in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: The effectiveness of Xeljanz in rheumatoid arthritis patientsShinshu UniversityShowa Inan General HospitalRecruiting20 Years90 YearsAll100Phase 4Japan
450NCT02123264
(ClinicalTrials.gov)
May 201423/4/2014Zoledronic Acid in Rheumatoid ArthritisRandomized Clinical Trial on the Prevention of Radiographic Progression With Zoledronic Acid in Patients With Early Rheumatoid Arthritis and Low Disease ActivityArthritis, RheumatoidDrug: Zoledronic acidCarmen Gómez-VaqueroNULLTerminated18 YearsN/AAll28Phase 3Spain
451NCT02115750
(ClinicalTrials.gov)
May 201414/4/2014Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA)A Double-Blind, Randomized, Parallel-Group, Active-Control Study to Compare the Efficacy and Safety of CHS-0214 Versus Enbrel in Subjects With Rheumatoid Arthritis and Inadequate Response to Treatment With MethotrexateRheumatoid ArthritisDrug: Etanercept;Drug: CHS-0214Coherus Biosciences, Inc.Daiichi Sankyo Co., Ltd.Completed18 YearsN/AAll647Phase 3United States;Belarus;France;Germany;Hungary;Israel;Japan;Poland;Russian Federation;South Africa;Spain;United Kingdom
452NCT02927509
(ClinicalTrials.gov)
May 201415/9/2016Evaluation of Tumour Necrosis Factor Alpha (TNFa) Blockers in Early Rheumatoid Arthritis in FranceRheumatoid ArthritisDrug: TNF alpha blockersCentre Hospitalier Universitaire de NimesPfizer;PfizerCompleted18 Years70 YearsBoth813N/ANULL
453NCT04582084
(ClinicalTrials.gov)
April 4, 20143/10/2020Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune ArthritisAssessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (ASQA): a Multicenter Post-marketing Surveillance StudyRheumatoid Arthritis;Ankylosing Spondylitis;Psoriatic ArthritisDrug: EtanerceptAryoGen Pharmed Co.NULLCompleted18 YearsN/AAll583Iran, Islamic Republic of
454NCT02109289
(ClinicalTrials.gov)
April 20143/4/2014Etanercept in Rheumatoid Arthritis and Vascular InflammationPilot Open-label Study of the Effect of Etanercept on Vascular Inflammation in Patients With Active Rheumatoid ArthritisRheumatoid Arthritis;Vascular InflammationDrug: etanerceptInnovaderm Research Inc.NULLTerminated18 Years80 YearsAll5Phase 4Canada
455NCT02066389
(ClinicalTrials.gov)
March 26, 201417/2/2014A Study Investigating the Efficacy and Safety of Upadacitinib (ABT-494) Given With Methotrexate (MTX) in Adults With Rheumatoid Arthritis Who Have Had an Inadequate Response to MTX AloneA Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Investigate the Safety and Efficacy of ABT-494 With Background Methotrexate (MTX) in Subjects With Active Rheumatoid Arthritis (RA) Who Have Had an Inadequate Response to MTX AloneRheumatoid ArthritisDrug: Placebo;Drug: UpadacitinibAbbVieNULLCompleted18 Years100 YearsAll300Phase 2United States;Bulgaria;Chile;Czechia;Hungary;Israel;Latvia;Mexico;Poland;Puerto Rico;Russian Federation;Slovakia;South Africa;Spain;Turkey;Ukraine;Czech Republic;Romania;Serbia
456NCT02092467
(ClinicalTrials.gov)
March 14, 20143/3/2014Safety Study Of Tofacitinib Versus Tumor Necrosis Factor (TNF) Inhibitor In Subjects With Rheumatoid ArthritisPHASE 3B/4 RANDOMIZED SAFETY ENDPOINT STUDY OF 2 DOSES OF TOFACITINIB IN COMPARISON TO A TUMOR NECROSIS FACTOR (TNF) INHIBITOR IN SUBJECTS WITH RHEUMATOID ARTHRITISArthritis, RheumatoidDrug: tofacitinib;Biological: adalimumab;Biological: etanerceptPfizerNULLCompleted50 YearsN/AAll4372Phase 4United States;Argentina;Australia;Brazil;Bulgaria;Canada;Chile;China;Colombia;Czechia;Finland;Hong Kong;Israel;Jordan;Lebanon;Malaysia;Mexico;Netherlands;New Zealand;Peru;Poland;Puerto Rico;Russian Federation;Slovakia;South Africa;Spain;Taiwan;Thailand;Turkey;United Kingdom;Austria;Czech Republic;Sweden
457NCT02046603
(ClinicalTrials.gov)
March 4, 201424/1/2014A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic AgentOpen-Label, Phase IIIb Study to Evaluate the Efficacy and Safety of Subcutaneous (SC) Tocilizumab Monotherapy or Combination Therapy With Methotrexate (MTX) or Other Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Patients With Active Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-Tumour Necrosis Factor (Anti-TNF) Biologic AgentRheumatoid ArthritisDrug: Tocilizumab;Drug: DMARDs;Drug: Oral Corticosteroids;Drug: MethotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll162Phase 3United Kingdom
458NCT02057250
(ClinicalTrials.gov)
March 201431/1/2014To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid ArthritisA Multicenter, Randomized, Open-Label, Parallel-Group Usability Study Of The Sarilumab Auto-Injector Device And A Prefilled Syringe In Patients With Moderate To Severe Active Rheumatoid Arthritis Who Are Candidates For Anti-IL6R TherapyRADrug: Sarilumab;Device: Auto-Injector Device (AID);Device: Pre-filled Syringe (PFS);Drug: Methotrexate;Drug: Sulfasalazine;Drug: Leflunomide;Drug: HydroxychloroquineSanofiRegeneron PharmaceuticalsCompleted18 YearsN/AAll217Phase 3United States;Chile;Mexico;Poland;Russian Federation;South Africa;France
459NCT02097524
(ClinicalTrials.gov)
March 20143/3/2014Single-dose Study to Describe the Pharmacodynamics (PD) and Safety of Sarilumab (REGN88/SAR153191) and Tocilizumab in Adults With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Sarilumab;Drug: TocilizumabRegeneron PharmaceuticalsSanofiCompleted18 YearsN/ABoth105Phase 1United States
460NCT02029599
(ClinicalTrials.gov)
March 201426/12/2013The Efficacy and Safety of Fang yi Qing Feng Shi Granules in Subjects With Rheumatoid ArthritisA Phase 2 Randomised, Double-blind, Placebo-controlled Multiple Ascending Dose Study Evaluate the Efficacy and Safety of Fang yi Qing Feng Shi Granules in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: Fang yi qing feng shi granule;Drug: placebo;Drug: Methotrexate;Drug: Acetaminophen tabletsMaoxiang Group Jilin Pharmaceutical Co., Ltd.NULLCompleted18 Years65 YearsBoth240Phase 2China
461NCT02065700
(ClinicalTrials.gov)
February 25, 201414/2/2014Long-term Follow-up Study of GLPG0634 in Active Rheumatoid Arthritis PatientsA Multicenter, Open-label, Long-term Follow-up Safety and Efficacy Study of GLPG0634 Treatment in Subjects With Moderately to Severely Active Rheumatoid ArthritisRheumatoid ArthritisDrug: FilgotinibGalapagos NVGilead SciencesCompleted18 YearsN/AAll739Phase 2United States;Argentina;Australia;Belgium;Bulgaria;Chile;Colombia;Czechia;France;Germany;Guatemala;Hungary;Israel;Latvia;Mexico;Moldova, Republic of;New Zealand;Poland;Romania;Russian Federation;Spain;Ukraine;Czech Republic
462NCT02434757
(ClinicalTrials.gov)
February 201430/4/2015Addition of H.P. Acthar Gel to Treatment Regimen of Patients With Rheumatoid ArthritisAddition of H. P Acthar Gel to Treatment Regimen of Patients With Rheumatoid Arthritis Inadequately Controlled With Biologic Disease-Modifying Antirheumatic DrugsRheumatoid ArthritisDrug: H.P. Acthar GelRonald J. Rapoport, MDQuestcor Pharmaceuticals, Inc.Recruiting18 YearsN/ABoth10N/AUnited States
463NCT02169544
(ClinicalTrials.gov)
January 31, 201414/5/2014Post-marketing Study Assessing the Long-Term Safety of AbataceptPost-marketing Study Assessing the Long-Term Safety of AbataceptRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll100000N/ANULL
464NCT01987479
(ClinicalTrials.gov)
January 30, 20148/11/2013A Study on Safety and Efficacy of Tocilizumab (RoActemra/Actemra) Alone or in Combination With Non-Biologic Antirheumatics in Participants With Rheumatoid ArthritisMulti-Center, Open Label, Single Arm Phase IIIB Study on Safety and Efficacy of Subcutaneous Tocilizumab in Monotherapy or in Combination With Methotrexate or Other Non-Biologic Disease Modifying Antirheumatic Drugs in Rheumatoid Arthritis Patients With an Inadequate Response to Non-Biologic DMARDs - OSCARRheumatoid ArthritisDrug: Non-Biologic DMARDs;Drug: Tocilizumab;Drug: MethotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll150Phase 3Netherlands
465NCT02049138
(ClinicalTrials.gov)
January 24, 201428/1/2014An Open-label Extension Study Evaluating the Safety and Efficacy of Upadacitinib (ABT-494) in Rheumatoid Arthritis SubjectsA Phase 2 Study, Multicenter, Open-Label Extension (OLE) Study in Rheumatoid Arthritis Subjects Who Have Completed a Preceding Phase 2 Randomized Controlled Trial (RCT) With Upadacitinib (ABT-494)Rheumatoid ArthritisDrug: ABT-494AbbVieNULLCompleted18 Years100 YearsAll494Phase 2New Zealand;Poland;Puerto Rico;Russian Federation;Slovakia;South Africa;Spain;Ukraine;United Kingdom;Belgium;Bulgaria;Chile;Czechia;Hungary;Israel;Latvia;Mexico;United States;Australia;Czech Republic
466NCT01988506
(ClinicalTrials.gov)
January 6, 20147/11/2013Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory DiseasesInduction of Regulatory t Cells by Low Dose IL2 in Autoimmune and Inflammatory Diseases: a Transnosographic ApproachRheumatoid Arthritis;Ankylosing Spondylitis;Systemic Lupus Erythematosus;Psoriasis;Behcet's Disease;Wegener's Granulomatosis;Takayasu's Disease;Crohn's Disease;Ulcerative Colitis;Autoimmune Hepatitis;Sclerosing Cholangitis;Gougerot-sjögren;Idiopathic Thrombocytopenic Purpura;Systemic SclerosisDrug: Interleukin 2Assistance Publique - Hôpitaux de ParisIltoo PharmaCompleted18 YearsN/AAll81Phase 2France
467NCT02031471
(ClinicalTrials.gov)
January 201416/12/2013TOSCARA Study: A Study of Subcutaneous Tocilizumab (RoActemra/Actemra) in Participants With Active Rheumatoid Arthritis Naïve to RoActemra/Actemra TreatmentTOSCARA: An Open-label, Single Arm Study to Evaluate the Efficacy, Safety and Tolerability of Tocilizumab (TCZ) Subcutaneous in TCZ-naïve Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll57Phase 3Belgium;Luxembourg
468NCT02017639
(ClinicalTrials.gov)
January 20142/12/2013Sarilumab Effect on the Pharmacokinetics of SimvastatinA Multi-center, Open-label, 2-treatment, Single-sequence Clinical Study to Evaluate the Effects of a Single 200 mg Subcutaneous Injection of Sarilumab on the Pharmacokinetics of a Single 40 mg Oral Dose of Simvastatin, With Optional 1-year Extension of Open Label Treatment of Sarilumab, in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: sarilumab SAR153191 (REGN88);Drug: simvastatinSanofiRegeneron PharmaceuticalsCompleted18 Years75 YearsBoth19Phase 1United States;Korea, Republic of;Moldova, Republic of
469NCT02000336
(ClinicalTrials.gov)
January 201419/11/2013Comparison of the Effectiveness of Two Different Dosages of Cortisone Compared to Placebo in Rheumatoid ArthritisComparison of the Efficacy and Safety of Two Different Starting Dosages of Prednisolone in Early Active Rheumatoid Arthritis: a Randomized, Placebo Controlled TrialProgression of Rheumatoid ArthritisDrug: Prednisolone;Drug: PlaceboProf. Dr. rer. nat. H.J. TrampischRuhr University of BochumCompleted18 YearsN/AAll395Phase 3Germany
470NCT02001987
(ClinicalTrials.gov)
January 201429/11/2013A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic TherapyA Multi-Center Open-Label Study to Evaluate the Efficacy, Safety and Tolerability of Subcutaneous Tocilizumab in Tocilizumab-Naive Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic DMARD and/or Biologic TherapyRheumatoid ArthritisDrug: Tocilizumab;Drug: Methotrexate;Drug: csDMARDsHoffmann-La RocheNULLCompleted18 YearsN/AAll139Phase 3France
471NCT01668966
(ClinicalTrials.gov)
December 9, 201316/8/2012A Long Term Extension Study of WA19926 (NCT01007435) of Tocilizumab (RoActemra/Actemra) in Participants With Early, Moderate to Severe Rheumatoid Arthritis (RA)A Multicenter, Open-Label, Single Arm, Long Term Extension Study of WA19926 to Describe Safety During Treatment With Tocilizumab in Patients With Early, Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 MonthsN/AAll23Phase 3Brazil
472NCT02047604
(ClinicalTrials.gov)
December 201322/1/2014(C2013-0302) Safety and Efficacy of Escalating Doses of SAN-300 in Patients With Rheumatoid ArthritisA Randomized, Double-blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of Escalating Doses of SAN-300 in Patients With Active Rheumatoid Arthritis With Inadequate Response to Disease-Modifying Anti-rheumatic Drug(s).Rheumatoid ArthritisDrug: SAN-300 0.5 mg/kg QW;Drug: SAN-300 1.0 mg/kg QW;Drug: SAN-300 2.0 mg/kg QOW;Drug: SAN-300 4.0 mg/kg QOW;Drug: SAN-300 4.0 mg/kg QW;Drug: PlaceboBausch Health Americas, Inc.NULLCompleted18 Years75 YearsAll41Phase 2United States
473NCT02056184
(ClinicalTrials.gov)
December 201330/1/2014Targeted Ultrasound in Rheumatoid ArthritisTargeted Ultrasound in Rheumatoid ArthritisRheumatoid Arthritis;Targeted UltrasoundDrug: AdalimumabUniversity of LeedsAbbVie;TheoremCompleted18 YearsN/AAll183Phase 4United Kingdom
474NCT03736044
(ClinicalTrials.gov)
November 25, 201311/10/2018Reconstitution of CD4+CD25highCD127low/-TcellAnalysis of T Cell Population to Obtain a Free-drug Remission in Patients Affected by Rheumatoid Athritis in Remission Phase Induced by TNF-blocker TherapyRheumatoid ArthritisDrug: TNF-blockers suspension in patients with rheumatoid arthritisUniversity Hospital of FerraraNULLCompleted18 YearsN/AAll48Phase 1NULL
475NCT01941095
(ClinicalTrials.gov)
November 20, 201330/8/2013A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid ArthritisMulticenter, Open Label, Phase IIIb Study to Evaluate the Safety and Tolerability of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Methotrexate or Other Non-Biologic Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Azathioprine;Drug: Chloroquine;Drug: Hydroxychloroquine;Drug: Leflunomide;Drug: Methotrexate;Drug: Sulfasalazine;Drug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll100Phase 3Greece
476NCT02293590
(ClinicalTrials.gov)
November 201330/10/2014RICE: Remission by Intra-articular Injection Plus CErtolizumabAn Open Label, Randomised Study to Compare the Efficacy of Certolizumab Pegol (CZP) Plus a Dynamic or Fixed Dose Treatment Strategy in Patients With Rheumatoid Arthritis, a Phase II StudyRheumatoid ArthritisDrug: Certolizumab PegolRüdiger B. MüllerUCB PharmaCompleted18 YearsN/AAll43Phase 2Switzerland
477NCT02254655
(ClinicalTrials.gov)
November 201318/11/2013The Effect of Puerarin Injection on Carotid Intima-Media Thickness in Patients With Rheumatoid ArthritisThe Effect of Puerarin Injection on Carotid Intima-Media Thickness in Patients With Rheumatoid Arthritis, a Controlled and Randomized TrialRheumatoid ArthritisDrug: Puerarin injection 400 mg;Drug: ControlChengdu PLA General HospitalNULLCompleted18 Years75 YearsAll119Phase 2China
478NCT01855789
(ClinicalTrials.gov)
November 201314/5/2013A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous Tocilizumab With Methotrexate in Participants With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Placebo;Drug: Tocilizumab;Drug: methotrexateHoffmann-La RocheNULLCompleted18 YearsN/ABoth718Phase 3United States
479NCT01951170
(ClinicalTrials.gov)
November 201323/9/2013An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid ArthritisAn Open-Label Study to Evaluate Non-Progression Of Structural Joint Damage Of Subcutaneous Tocilizumab In Patients With Moderate To Severe Active Rheumatoid Arthritis (Ac-Cute)Rheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll52Phase 3Australia
480NCT02005757
(ClinicalTrials.gov)
November 20134/12/2013Efficacy and Safety Study of Mizoribine in Active Rheumatoid (AMOLED)Open Label, Multicenter, Randomized Study to Assess the Efficacy and Safety of Mizoribine in Active Rheumatoid Arthritis Patients Unsuccessfully Treated With Disease-modifying Antirheumatic DrugRheumatoid ArthritisDrug: Bredinin tablet 150mg;Drug: Bredinin tablet 50mgChong Kun Dang PharmaceuticalNULLRecruiting20 Years80 YearsBoth60Phase 2Korea, Republic of
481NCT01990157
(ClinicalTrials.gov)
November 20135/11/2013Safety, Tolerability, Pharmacodynamics and Efficacy Study of TAB08 in Patients With Rheumatoid ArthritisSafety, Tolerability, Pharmacodynamics and Efficacy Study of TAB08 in Patients With Rheumatoid Arthritis in Which Methotrexate (MTX) Treatment is Not EffectiveRheumatoid ArthritisDrug: TAB08Theramab LLCNULLCompleted18 Years65 YearsAll18Phase 1/Phase 2Russian Federation
482NCT02027298
(ClinicalTrials.gov)
November 201318/11/2013Abatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II StudyAbatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II StudyPrimary Sjogren's Syndrome;Secondary Sjogren's Syndrome;Inflammatory Arthritis;Rheumatoid ArthritisDrug: AbataceptThe Cleveland ClinicBristol-Myers SquibbWithdrawn18 YearsN/AAll0Phase 2United States
483NCT01894516
(ClinicalTrials.gov)
October 8, 20134/7/2013Dose-finding Study of GLPG0634 as Monotherapy in Active Rheumatoid Arthritis (RA) Participants (DARWIN2)Randomized, Double-blind, Placebo-controlled, Multicenter, Phase IIb Dose Finding Study of GLPG0634 Administered for 24 Weeks as Monotherapy to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate (MTX) AloneRheumatoid ArthritisDrug: GLPG0634;Drug: PlaceboGalapagos NVNULLCompleted18 YearsN/AAll287Phase 2United States;Argentina;Australia;Austria;Bulgaria;Chile;Colombia;Germany;Guatemala;Hungary;Latvia;Mexico;Moldova, Republic of;New Zealand;Poland;Romania;Russian Federation;Spain;Ukraine
484NCT01773681
(ClinicalTrials.gov)
October 201316/1/2013Novel Imaging Markers for Rheumatoid ArthritisNovel Imaging Markers for Rheumatoid ArthritisRheumatoid ArthritisDrug: Cimzia;Device: Magnetic Resonance Imaging (MRI);Device: High-resolution peripheral quantitative computed tomography (HR-pQCT)University of California, San FranciscoNULLCompleted18 YearsN/AAll30United States
485NCT01973569
(ClinicalTrials.gov)
October 201325/10/2013AMG 162 (Denosumab) Phase 3 Study (DESIRABLE Study) in Participants With Rheumatoid Arthritis on Disease-modifying Antirheumatic Drugs (DMARDs) TreatmentA Confirmatory Study of AMG 162 (Denosumab) in Patients With Rheumatoid Arthritis on DMARDs Treatment (Phase III)Rheumatoid ArthritisDrug: denosumab;Drug: placeboDaiichi Sankyo, Inc.NULLCompleted20 YearsN/AAll679Phase 3Japan
486NCT01962337
(ClinicalTrials.gov)
October 201310/10/2013A Phase 1, Randomized, Double Blind, Placebo Controlled, Single and Multiple Ascending Dose Study of FPA008 in Healthy Volunteers and Subjects With Rheumatoid ArthritisA Phase 1, Randomized, Double Blind, Placebo Controlled, Single and Multiple Ascending Dose Study of FPA008 in Healthy Volunteers and Subjects With Rheumatoid ArthritisHealthy;Rheumatoid ArthritisDrug: FPA008;Drug: PlaceboFive Prime Therapeutics, Inc.NULLTerminated21 Years70 YearsAll66Phase 1Hungary;Netherlands;Poland
487NCT01960855
(ClinicalTrials.gov)
October 20139/10/2013A Study Investigating the Efficacy and Safety of ABT-494 Given With Methotrexate in Subjects With Rheumatoid Arthritis Who Failed Anti-Tumor Necrosis Factor (TNF) Biologic TherapyA Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Investigate the Safety and Efficacy of ABT-494 Given With Methotrexate (MTX) in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Who Have Had an Inadequate Response or Intolerance to Anti-TNF Biologic TherapyRheumatoid ArthritisDrug: ABT-494;Drug: PlaceboAbbVieNULLCompleted18 YearsN/AAll276Phase 2Australia;Belgium;Canada;Czech Republic;Hungary;Netherlands;New Zealand;Poland;Puerto Rico;Spain;United Kingdom;United States
488NCT01966718
(ClinicalTrials.gov)
October 201314/10/2013Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies.Repository Corticotropin Injection As Adjunctive Therapy In Patients With Rheumatoid Arthritis Who Have Failed At Least Three Biologic Therapies With Different Modes Of ActionRheumatoid ArthritisDrug: Repository corticotropin injectionArthritis Treatment Center, MarylandNULLCompleted18 Years80 YearsAll8Phase 4United States
489NCT01975610
(ClinicalTrials.gov)
October 201329/10/2013Efficacy and Safety Study of CC-292 Versus Placebo as Co-therapy With Methotrexate in Active Rheumatoid ArthritisA Phase 2a, 4-Week Double-Blind, Proof-of-Concept Efficacy and Safety Study of CC-292 Versus Placebo as Co-therapy With Methotrexate in Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CC-292;Drug: PlaceboCelgeneNULLCompleted18 Years80 YearsFemale47Phase 2United States
490NCT01999192
(ClinicalTrials.gov)
October 201317/11/2013Study to Investigate the Safety and Efficacy of Tregalizumab in Subjects (MTX-IR) With Active Rheumatoid ArthritisA 24-week Phase IIb, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Investigate the Efficacy and Safety of Tregalizumab (BT061) in Combination With Methotrexate in the Treatment of Subjects With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate Alone, Followed by a 24-week Extension Phase: T Cell REgulating Arthritis Trial 2b (TREAT 2b)Rheumatoid ArthritisDrug: Tregalizumab;Drug: PlaceboBiotestAbbVieTerminated18 Years75 YearsAll321Phase 2United States;Bulgaria;Canada;Czechia;Estonia;Germany;Hungary;Lithuania;Mexico;Poland;Russian Federation;Serbia;Slovakia;Ukraine;Czech Republic;Sweden
491NCT01907230
(ClinicalTrials.gov)
September 10, 201314/7/2013Entecavir for Biological Agents Associated HBV Reactivation in Inflammatory Arthritis PatientsPropylactic Use of Entecavir for Biological Agents Associated Hepatitis B Virus Reactivation in Inflammatory Arthritis Patients: a Randomized Controlled TrialRheumatoid Arthritis;Hepatitis B Reactivation;Exposure to Hepatitis B VirusDrug: EntecavirTaipei Veterans General Hospital, TaiwanNULLActive, not recruiting20 Years90 YearsAll115Phase 4Taiwan
492NCT01941940
(ClinicalTrials.gov)
September 5, 20132/9/2013A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) ParticipantsA National, Open-Label, Single-Arm, Phase IIIb Study to Evaluate the Efficacy of Weekly Tocilizumab Subcutaneous, Administered as Monotherapy or in Combination With Methotrexate and/or Other DMARDs in Rheumatoid Arthritis (RA) PatientsRheumatoid ArthritisDrug: Tocilizumab;Drug: DMARDsHoffmann-La RocheNULLCompleted18 YearsN/AAll227Phase 3Italy
493NCT02600455
(ClinicalTrials.gov)
September 20136/11/2015Use-Results Survey for ORENCIA® Subcutaneous Injection 125mg Syringe 1mLOutline of Use-Results Survey for ORENCIA® Subcutaneous Injection 125mg Syringe 1mLRheumatoid ArthritisDrug: OrenciaBristol-Myers SquibbOno Pharmaceutical Co. LtdCompleted18 YearsN/AAll505N/AJapan
494NCT01948388
(ClinicalTrials.gov)
September 20139/9/2013The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis PatientsStudy of The Effect of Corticotrophin in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients From a Clinical and Structural Perspective As Measured by a Clinical Disease Activity Index Score and Bone Edema, Synovitis and Erosions on Magnetic Resonance ImagingRheumatoid ArthritisDrug: corticotrophin 80 unitsGaylis, Norman B., M.D.NULLCompleted18 YearsN/AAll20Phase 4United States
495NCT02275299
(ClinicalTrials.gov)
September 201323/10/2014Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid ArthritisA Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Iguratimod or Leflunomide in Combination With Methotrexate in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Iguratimod;Drug: Leflunomide;Drug: MethotrexateJiangsu Simcere Pharmaceutical Co., Ltd.NULLRecruiting18 Years70 YearsBoth240Phase 4China
496NCT01787149
(ClinicalTrials.gov)
September 20136/2/2013A Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of ENIA11 in Combination With DMARDs Versus DMARDs Alone in Patients With Rheumatoid ArthritisA Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of ENIA11 in Combination With DMARDs Versus DMARDs Alone in Patients With Rheumatoid ArthritisCombination With DMARDsDrug: DMARDsMycenax Biotech Inc.NULLUnknown status20 YearsN/AAll98Phase 3Taiwan
497NCT01783015
(ClinicalTrials.gov)
September 201331/1/2013Study of Etanercept in Subjects With Rheumatoid Arthritis Who Have Had an Inadequate Response to Adalimumab or Infliximab Plus MethotrexateA Randomized, Double-blind, Placebo-controlled Study Of The Safety And Efficacy Of Etanercept In Subjects With Rheumatoid Arthritis Who Have Had An Inadequate Response To Adalimumab Or Infliximab Plus MethotrexateRheumatoid ArthritisDrug: Etanercept;Drug: PlaceboPfizerNULLTerminated18 Years79 YearsAll16Phase 4Australia;Belgium;France;Hong Kong;Israel;Russian Federation;Spain;Netherlands
498NCT02600468
(ClinicalTrials.gov)
September 20136/11/2015Survey on Long-Term Use of ORENCIA® Intravenous Infusion 250mgOutline of Survey on Long-Term Use of ORENCIA® Intravenous Infusion 250mgRheumatoid ArthritisDrug: OrenciaBristol-Myers SquibbOno Pharmaceutical Co. LtdCompleted18 YearsN/AAll671N/ANULL
499NCT01955603
(ClinicalTrials.gov)
September 201324/9/2013A Trial to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0215-0384 Administered to Subjects With Moderate to Severe Rheumatoid ArthritisA Randomised, Placebo-controlled, Double-blind Within Cohort, Dose Escalation, Multiple-dose Trial to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0215-0384 Administered Subcutaneously to Subjects With Moderate to Severe Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC0215-0384;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsBoth24Phase 1Germany;Hungary;Poland;Russian Federation
500NCT01995201
(ClinicalTrials.gov)
September 20131/11/2013A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid ArthritisA Phase IIIb Study to Evaluate the Efficacy, Safety and Tolerability of Subcutaneous (SC) Tocilizumab (TCZ) Given as Monotherapy or in Combination With Methotrexate (MTX) or Other Non Biologics DMARDs in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: DMARD;Drug: methotrexate;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLActive, not recruiting18 YearsN/ABoth401Phase 3Ireland;Portugal;Spain
501NCT02072200
(ClinicalTrials.gov)
September 201314/2/2014Efficacy of Lodotra®(Prednisone) in Reduction of Morning Stiffness Duration(K-IMPROvE)A New Modified-Release Tablet Formulation of Prednisone in Patients With Rheumatoid Arthritis- Multicenter, Phase IV, Interventional Study to Assess Reduction of Morning StiffnessRheumatoid ArthritisDrug: Lodotra®Mundipharma Korea LtdNULLCompleted20 Years80 YearsAll147Phase 4Korea, Republic of
502NCT01856309
(ClinicalTrials.gov)
August 7, 201315/5/2013Long-term Safety and Efficacy of Sirukumab in Participants With RA Completing Studies CNTO136ARA3002 or CNTO136ARA3003A Multicenter, Parallel-group Study of Long-term Safety and Efficacy of CNTO 136 (Sirukumab) for Rheumatoid Arthritis in Subjects Completing Treatment in Studies CNTO136ARA3002 (SIRROUND-D) and CNTO136ARA3003 (SIRROUND-T)Arthritis, RheumatoidDrug: Sirukumab 100 mg;Drug: Sirukumab 50 mg;Drug: PlaceboJanssen Research & Development, LLCGlaxoSmithKlineCompleted18 YearsN/AAll1820Phase 3United States;Argentina;Australia;Austria;Belgium;Bulgaria;Canada;Chile;Colombia;Croatia;France;Germany;Japan;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Puerto Rico;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Ukraine;United Kingdom
503NCT01936181
(ClinicalTrials.gov)
August 20132/9/2013A Study Comparing SB2 to Remicade® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate TherapyA Randomised, Double-blind, Parallel Group, Multicentre Clinical Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Immunogenicity of SB2 Compared to Remicade® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate TherapyRheumatoid ArthritisDrug: Remicade (infliximab);Drug: SB2 (proposed biosimilar to infliximab)Samsung Bioepis Co., Ltd.NULLCompleted18 Years75 YearsAll584Phase 3Bulgaria;Lithuania
504NCT01394913
(ClinicalTrials.gov)
August 201312/7/2011Comparison of Two Etanercept Regimens (REUMATOCEPT® Versus ENBREL®) for Treatment of Rheumatoid ArthritisA Prospective, Double-blind, Randomized Study to Compare Efficacy of Two Etanercept Regimens (REUMATOCEPT® Versus ENBREL®) for Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: Reumatocept (etanercept);Drug: Enbrel (etanercept)EMSNULLWithdrawn18 Years70 YearsAll0Phase 3Brazil
505NCT01905735
(ClinicalTrials.gov)
August 201319/7/2013A Safety and Efficacy of Homeopathic Medicine Rhus Toxicodendron 30 in the Treatment of Rheumatoid ArthritisA Multicentric,Double-blind,Placebo Controlled,Phase-2 Study to Assess the Safety and Efficacy of Homeopathic Medicine Rhus Toxicodendron 30 in the Treatment of Rheumatoid Arthritis .Rheumatoid Arthritis.Drug: Rhustoxicodendron 30;Drug: placeboHealthcare Homoeo Charitable SocietyNULLRecruiting25 Years60 YearsBoth60Phase 2India
506NCT01915537
(ClinicalTrials.gov)
August 201330/7/2013Infliximab and Classic DMARDs in the Rheumatoid Arthritis PatientsA Prospective Cohort Study to Observe the Difference of Efficacy Between Infliximab With Methotrexate and Classic DMARDs in the Severe Rheumatoid Arthritis Patients With Poor PrognosisRheumatoid Arthritis(RA)Drug: Infliximab group;Drug: Classic DMARDs treatment groupZhang, Xiao, M.D.Central South University;Tianjin Medical University General Hospital;Xijing HospitalNot yet recruiting18 Years70 YearsBoth170N/AChina
507NCT01932372
(ClinicalTrials.gov)
July 26, 201330/7/2013Tofacitinib (Xeljanz) Special Investigation for Rheumatoid ArthritisXELJANZ (REGISTERED) TABLETS 5MG SPECIAL INVESTIGATION (ALL-CASES SURVEILLANCE)Rheumatoid ArthritisDrug: Tofacitinib (Xeljanz);Drug: Etanercept, other Biologics, Disease-modifying antirheumatic drugs (DMARDs), etcPfizerNULLCompletedN/AN/AAll9968Japan
508NCT01888874
(ClinicalTrials.gov)
July 17, 201326/6/2013Dose-finding Study of GLPG0634 as add-on to Methotrexate in Active Rheumatoid Arthritis Participants (DARWIN1)Randomized, Double-blind, Placebo-controlled, Multicenter, Phase IIb Dose Finding Study of GLPG0634 Administered for 24 Weeks in Combination With Methotrexate to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate AloneRheumatoid ArthritisDrug: GLPG0634;Drug: PlaceboGalapagos NVNULLCompleted18 YearsN/AAll599Phase 2United States;Argentina;Australia;Austria;Belgium;Bulgaria;Chile;Colombia;Czechia;France;Germany;Guatemala;Hungary;Israel;Latvia;Mexico;Moldova, Republic of;New Zealand;Poland;Russian Federation;Spain;Ukraine;Czech Republic;Peru;Puerto Rico
509NCT01774877
(ClinicalTrials.gov)
July 201322/1/2013A Clinical Study of Xin'an Medicine in the Treatment of Bi SyndromeEfficacy and Safety of Xinfeng Capsule in the Treatment of Rheumatoid Arthritis (RA):A Randomized, Double-blind, Double-dummy, Multi-center TrialRheumatoid ArthritisDrug: Xinfeng capsule;Drug: leflunomideThe First Affiliated Hospital of Anhui University of Traditional Chinese MedicineMinistry of Science and Technology of the People´s Republic of ChinaCompleted18 Years65 YearsBoth304N/AChina
510NCT01851070
(ClinicalTrials.gov)
July 201319/4/2013A Multi-center Study a Single IV Infusion of Allogeneic MPCs in Patients With Rheumatoid Arthritis and Incomplete Response to at Least One TNFa InhibitorA Double-blind, Randomized, Placebo-controlled, Dose-escalation, Multi-center Study a Single Intravenous Infusion of Allogeneic Mesenchymal Precursor Cells (MPCs) in Patients With Rheumatoid Arthritis and Incomplete Response to at Least One TNFa InhibitorRheumatoid ArthritisDrug: Allogeneic Mesenchymal Precursor Cells;Drug: Normal SalineMesoblast, Ltd.PPDCompleted18 Years80 YearsAll48Phase 2United States;Australia
511NCT01890473
(ClinicalTrials.gov)
July 201327/6/2013Study to Characterize the Pharmacokinetics of a Single Dose of SC Abatacept 125 mg Using the BD Autoinjector or the Prefilled SyringePhase Ib, Multicenter, Randomized, Open-Label, Parallel-Group Study to Characterize the Pharmacokinetics of a Single Dose of Abatacept 125 mg Administered Subcutaneously Using the BD Physioject™ Autoinjector or the UltraSafe Passive Needle Guard Prefilled SyringeRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll356Phase 1United States;Argentina;Mexico;Peru;South Africa
512NCT02519387
(ClinicalTrials.gov)
July 201315/7/2015Efficacy and Safety of Buprenorphine Transdermal Patch in Non-cancer Pain of Moderate IntensityMulticentre Study for Evaluation of the Efficacy and Safety of Buprenorphine Transdermal Patch (SOVENOR®) 5mg and 10mg in Patients With Non-malignant Pain of Moderate Intensity Due to Osteoarthritis, Rheumatoid Arthritis, Lower Back Pain and Joint/Muscle Pain, When an Opioid is Necessary for Obtaining Adequate AnalgesiaOsteoarthritis;Rheumatoid Arthritis;Lower Back Pain;Joint Pain;Muscle PainDrug: Buprenorphine Transdermal PatchMundipharma Pharmaceuticals Sdn. Bhd.NULLCompleted40 YearsN/AAll78Phase 4Malaysia
513NCT01862224
(ClinicalTrials.gov)
July 20132/5/2013A Synovial Biopsy Study of JNJ-38518168 in Participants With Active Rheumatoid Arthritis Despite Methotrexate TherapyA Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Synovial Biopsy Study of JNJ-38518168 in Subjects With Active Rheumatoid Arthritis Despite Methotrexate TherapyRheumatoid ArthritisDrug: JNJ-38518168;Drug: Placebo;Drug: Placebo / JNJ-38518168Janssen Research & Development, LLCNULLTerminated18 Years65 YearsBoth21Phase 2United States;Moldova, Republic of
514NCT01864265
(ClinicalTrials.gov)
July 201321/5/2013Prediction of Response to Certolizumab Pegol Treatment by Functional MRI of the BrainPrediction of Response to Certolizumab Pegol Treatment by Functional MRI of the Brain. A Multi-center, Randomized Double-blind Controlled Study Prediction of Response to Certolizumab-Pegol in RA (PreCePRA)Rheumatoid ArthritisDrug: Certolizumab Pegol;Drug: PlaceboUniversity of Erlangen-Nürnberg Medical SchoolNULLCompleted18 YearsN/AAll156Phase 3Germany;Portugal;Serbia;Belgium;United Kingdom;United States
515NCT02236481
(ClinicalTrials.gov)
July 20138/9/2014Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and DiabetesNo-profit Study to Ensure Normal Clinical Practice, to Evaluate the Efficacy of Anakinra in Reducing the Glycated Haemoglobin in Patients Affected by Rheumatoid Arthritis and Diabetes; Randomized, Open Label, Parallel Group,Controlled Clinical StudyDiabetes Mellitus, Type 2;Arthritis, RheumatoidDrug: Anakinra;Drug: TNF alpha inhibitorsProf. Roberto GiacomelliNULLTerminated18 YearsN/AAll41Phase 4Italy
516NCT01893996
(ClinicalTrials.gov)
July 20132/7/2013Study of Adalimumab to Lower Cardiovascular Risk in RA Patients With Well Controlled Joint DiseaseAdalimumab to Mitigate Cardiovascular Risk in RA Patients With Well-Controlled Joint DiseaseRheumatoid Arthritis;Cardiovascular DiseaseDrug: Adalimumab;Drug: PlaceboJonathan GrafAmerican College of Rheumatology Research and Education Foundation;AbbVieCompleted18 YearsN/AAll63Phase 4United States
517NCT01885078
(ClinicalTrials.gov)
June 27, 201319/6/2013An Extension Study in Participants With Moderate to Severe Rheumatoid ArthritisA Phase 3, Multicenter Study to Evaluate the Long-Term Safety and Efficacy of Baricitinib in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Baricitinib;Drug: PlaceboEli Lilly and CompanyNULLCompleted18 YearsN/AAll2877Phase 3United States;Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Croatia;Czechia;Denmark;France;Germany;Greece;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Latvia;Lithuania;Mexico;Netherlands;Poland;Portugal;Puerto Rico;Romania;Russian Federation;Slovakia;Slovenia;South Africa;Spain;Sweden;Switzerland;Taiwan;Turkey;United Kingdom;Czech Republic
518NCT01881308
(ClinicalTrials.gov)
June 17, 201317/6/2013Assessing Withdrawal of Disease-Modifying Antirheumatic Drugs in Rheumatoid ArthritisREmission in Rheumatoid Arthritis - Assessing WIthrawal of Disease-modifying Antirheumatic Drugs in a Non-inferiority DesignRheumatoid ArthritisDrug: TNF inhibitors;Drug: Synthetic DMARD(s);Drug: Co-medication: Synthetic DMARDsDiakonhjemmet HospitalThe Research Council of Norway;South-Eastern Norway Regional Health AuthorityCompleted18 Years80 YearsAll320Phase 4Norway
519NCT01901185
(ClinicalTrials.gov)
June 11, 201317/5/2013Study to Evaluate the Ability of Subjects With Rheumatoid Arthritis or Psoriatic Arthritis to Effectively Use a Reusable Autoinjector to Self-inject EtanerceptA Single-arm, Multicenter Study to Evaluate the Ability of Subjects With Rheumatoid Arthritis or Psoriatic Arthritis to Effectively Use a Reusable Electromechanical Autoinjector to Self-inject EtanerceptRheumatoid Arthritis;Psoriatic ArthritisDrug: Etanercept / Autoinjector AAmgenNULLCompleted18 YearsN/AAll77Phase 3United States
520NCT01875991
(ClinicalTrials.gov)
June 5, 201310/6/2013Preference Between Two Autoinjectors in Patients With Rheumatoid Arthritis and Plaque Psoriasis Treated With EtanerceptAn Open-label, Randomized, Crossover Study to Assess the Preference for Autoinjector A Versus Autoinjector B in Rheumatoid Arthritis and Plaque Psoriasis Subjects Treated With EtanerceptRheumatoid Arthritis;Plaque PsoriasisDrug: Etanercept via Autoinjector A;Drug: Etanercept via Autoinjector BAmgenNULLCompleted18 YearsN/AAll217Phase 4United States;Canada
521NCT02132234
(ClinicalTrials.gov)
June 201328/4/2014Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing SpondylitisEffects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing SpondylitisRheumatoid Arthritis;Psoriatic Arthritis;Ankylosing Spondylitis;HypertensionDrug: Etanercept;Drug: Adalimumab;Drug: Certolizumab;Drug: InfliximabJagiellonian UniversityDepartmet of Rheumatology, J Dietl Hospital, Krakow, PolandRecruiting18 YearsN/ABoth100Phase 4Poland
522NCT01895309
(ClinicalTrials.gov)
June 20133/7/2013A Study Comparing SB4 to Enbrel® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate TherapyA Randomised, Double-blind, Parallel Group, Multicentre Clinical Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Immunogenicity of SB4 Compared to Enbrel® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate TherapyRheumatoid ArthritisDrug: Enbrel (etanercept);Drug: SB4 (proposed biosimilar to etanercept)Samsung Bioepis Co., Ltd.NULLCompleted18 Years75 YearsAll596Phase 3Poland;United Kingdom
523NCT01878318
(ClinicalTrials.gov)
June 20136/6/2013A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDsOpen Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDsRheumatoid ArthritisDrug: methotrexate;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLWithdrawn18 YearsN/ABoth0Phase 4Venezuela
524NCT01961271
(ClinicalTrials.gov)
June 20137/10/2013Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle PainMulticentre Study To Evaluate Efficacy And Safety Of Buprenorphine Transdermal Patch (Norspan) In Chronic Non-Malignant Pain Of Moderate To Severe Intensity Due To Osteoarthritis, Rheumatoid Arthritis, Lower Back Pain And Joint / Muscle Pain, When Opioid Is Needed For AnalgesiaOsteoarthritis;Rheumatoid Arthritis;Lower Back Pain;Joint Pain;Muscle PainDrug: Buprenorphine transdermal patchMundipharma Pte Ltd.Mundipharma Korea Ltd;Mundipharma (Hong Kong) Ltd;Mundipharma Distribution GmBH (Philippine Branch)Completed18 Years80 YearsAll114Phase 4Hong Kong;Korea, Republic of;Philippines
525NCT01909427
(ClinicalTrials.gov)
June 201310/7/2013An Efficacy And Safety Study of CNTO 6785 In Participants With Active Rheumatoid Arthritis Despite Methotrexate TherapyA Randomized, Placebo-controlled Double-blind, Multicenter, Phase 2 Dose Ranging Study To Assess The Efficacy And Safety of CNTO 6785 In Subjects With Active Rheumatoid Arthritis Despite Methotrexate TherapyRheumatoid ArthritisDrug: Placebo;Drug: CNTO 6785 200 mg;Drug: CNTO 6785 100 mg;Drug: CNTO 6785 50 mg;Drug: CNTO 6785 15 mgJanssen Research & Development, LLCNULLCompleted18 Years80 YearsBoth257Phase 2Argentina;Colombia;Czech Republic;Philippines;Poland;Russian Federation;Thailand
526NCT01955733
(ClinicalTrials.gov)
May 31, 201330/9/2013Safety and Efficacy of BI 695500 in Patients With Moderately to Severely Active Rheumatoid ArthritisSafety and Efficacy of BI 695500 in Patients With Moderately to Severely Active Rheumatoid Arthritis: an Open-label Extension TrialArthritis, RheumatoidDrug: BI 695500Boehringer IngelheimNULLTerminated18 Years82 YearsAll91Phase 3United States;Belgium;Bulgaria;Germany;Greece;Netherlands;Poland;Portugal;Spain;Argentina;Brazil;Canada;Chile;Hungary;Ireland;Mexico;United Kingdom
527NCT04157010
(ClinicalTrials.gov)
May 201315/4/2014Tocilizumab REMission in Early RAProspective, Single-centre, Open-Label, Randomised, Pilot Study Assessing the Changes in Expression of Janus Kinase/Signal Transducers and Activators of Transcription (JAK-STAT) and Speed & Depth of Remission Induced by Tocilizumab & Methotrexate Combination and Tocilizumab Monotherapy in Patients With Early Rheumatoid ArthritisRheumatoid ArthritisDrug: Tocilizumab;Drug: MethotrexateUniversity of LeedsHoffmann-La RocheCompleted18 YearsN/AAll20Phase 4United Kingdom
528NCT01873443
(ClinicalTrials.gov)
May 201322/5/2013Long-Term Efficacy and Safety of CT-P10 in Patients With RAAn Open-Label, Single-Arm, Maintenance Study to Demonstrate Long-Term Efficacy and Safety of CT-P10 in Patients With Rheumatoid Arthritis Who Were Treated With Rituximab (MabThera or CT-P10) in Study CT-P10 1.1Rheumatoid ArthritisDrug: Rituximab, MTX, folic acidCelltrionNULLCompleted18 Years75 YearsBoth87Phase 1Korea, Republic of
529NCT02035800
(ClinicalTrials.gov)
May 201310/12/2013Bone Resorption, Osteoclastogenesis and AdalimumabBone Resorption, Osteoclastogenesis and AdalimumabRheumatoId ArthritisDrug: AdalimumabUniversité de SherbrookeAbbVieUnknown status18 YearsN/AAll120Phase 4Canada
530NCT01357759
(ClinicalTrials.gov)
May 201318/5/2011Safety and Tolerability of MORAb-022 in Healthy and Rheumatoid Arthritis SubjectsA Randomized, Double-Blind, Placebo-Controlled, Single-Dose, Dose-Escalation Trial of MORAb-022 in Healthy Subjects and Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: MORAb-022MorphotekNULLCompleted18 Years75 YearsBoth20Phase 1United States;Netherlands
531NCT01846975
(ClinicalTrials.gov)
May 201319/4/2013Introducing a Single IV Abatacept Treatment in RA Patients Currently Receiving Weekly SC Abatacept to Simulate a HolidayA Phase IV, Open Label Study Introducing a Single IV Treatment With Abatacept in Patients With Rheumatoid Arthritis Currently Receiving Weekly Injections of SC Abatacept to Simulate a Holiday or Patient VacationRheumatoid ArthritisDrug: IV AbataceptRüdiger B. MüllerBristol-Myers SquibbCompleted18 YearsN/ABoth49Phase 4Switzerland
532NCT02468791
(ClinicalTrials.gov)
May 20139/6/2015MabionCD20® Compared to MabThera® in Patients With Rheumatoid ArthritisA Randomized, Double-blind, Parallel-group Comparative Bioequivalence Trial of MabionCD20® (Mabion SA) Compared to MabThera® (Rituximab, Roche) in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: RituximabMabion SANULLCompleted18 Years80 YearsAll709Phase 3Bosnia and Herzegovina;Georgia;Poland;Serbia;Ukraine
533NCT01844895
(ClinicalTrials.gov)
April 20135/4/2013Methotrexate-Inadequate Response Autoinjector Device Sub StudySubstudy-A Phase IIIB Multicenter, Randomized, Double-Blind, Double-Dummy Study to Compare the Efficacy and Safety of Abatacept Administered Subcutaneously and Intravenously in Subjects With Rheumatoid Arthritis, Receiving Background Methotrexate, and Experiencing an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll120Phase 3NULL
534NCT01850680
(ClinicalTrials.gov)
April 20131/5/2013Single Ascending Dose Study of Safety and Tolerability of Sarilumab and Methotrexate in Japanese Patients With Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study of the Safety and Tolerability of Subcutaneously Administered Sarilumab in Japanese Patients With Rheumatoid Arthritis Receiving Concomitant MethotrexateRheumatoid ArthritisDrug: sarilumab SAR153191 (REGN88);Drug: placebo;Drug: methotrexate;Drug: folic acidSanofiRegeneron PharmaceuticalsCompleted20 Years65 YearsBoth61Phase 1Japan
535NCT01851278
(ClinicalTrials.gov)
April 201312/4/2013Effectiveness Intraarticular CorticosteroidEffectiveness and Tolerance Infiltration Intraarticular Corticosteroid According to DoseRheumatoid ArthritisDrug: Triamcinolone hexacetonideFederal University of São PauloFundação de Amparo à Pesquisa do Estado de São PauloRecruiting18 Years65 YearsBoth60N/ABrazil
536NCT01764997
(ClinicalTrials.gov)
April 20138/1/2013An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus MethotrexateA Randomized, Controlled Study of Sarilumab and Methotrexate (MTX) Versus Etanercept and MTX in Patients With Rheumatoid Arthritis (RA) and an Inadequate Response to 4 Months of Treatment With Adalimumab and MTXRheumatoid ArthritisDrug: Sarilumab;Drug: Etanercept;Drug: Methotrexate;Drug: Placebo (for sarilumab);Drug: Placebo (for etanercept);Drug: AdalimumabSanofiRegeneron PharmaceuticalsTerminated18 YearsN/AAll776Phase 3United States;Argentina;Australia;Brazil;Chile;Colombia;Czechia;Ecuador;Finland;France;Germany;Greece;Hungary;Israel;Italy;Korea, Republic of;Latvia;Lithuania;Malaysia;Mexico;New Zealand;Peru;Poland;Romania;Russian Federation;South Africa;Spain;Taiwan;Thailand;Ukraine;United Kingdom;Czech Republic
537NCT01830985
(ClinicalTrials.gov)
April 201310/4/2013A Phase 2/3 Open-label Extension Study to Evaluate Long-Term Safety and Efficacy With VX-509 in Subjects With Rheumatoid ArthritisA Phase 2/3 Open-label Extension Study to Evaluate Long-Term Safety and Efficacy With VX-509 in a Treat to Target Setting in Subjects With Rheumatoid Arthritis on Disease-Modifying Antirheumatic DrugsRheumatoid ArthritisDrug: VX-509Vertex Pharmaceuticals IncorporatedNULLCompleted18 Years65 YearsBoth39Phase 2/Phase 3United States;Estonia;Lithuania;South Africa
538NCT01851707
(ClinicalTrials.gov)
April 20138/5/2013A Double-Blind Study Evaluating Duvelisib in Subjects With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate AloneA Phase 2, Double-Blind, Parallel, Placebo-Controlled, Randomized Study to Evaluate Multiple Dose Levels of Duvelisib With Background Methotrexate in Subjects With Active Rheumatoid Arthritis and an Inadequate Response to Methotrexate AloneRheumatoid ArthritisDrug: IPI-145;Drug: PlaceboSecuraBioNULLCompleted18 Years70 YearsAll322Phase 2Bulgaria;Colombia;Germany;Hungary;Mexico;New Zealand;Poland;Romania;Russian Federation;Serbia;Ukraine
539NCT01558089
(ClinicalTrials.gov)
March 201315/2/2012Good EULAR Response In Patients With Early Rheumatoid ArthritisAbility To Achieve A Good Eular Response In Patients With Moderate-to-severe Active Early Rheumatoid Arthritis Who Satisfy The New Acr/Eular Classification Criteria Receiving Etanercept + Mtx In Real World Clinical Practice In GreeceRheumatoid ArthritisDrug: etanercept;Drug: methotrexatePfizerNULLCompleted18 YearsN/AAll76N/AGreece
540NCT02843789
(ClinicalTrials.gov)
March 201319/7/2016Evolution of Adipokines and Body Composition in Rheumatoid Arthritis Patients Receiving Tocilizumab TherapyEvolution of Adipokines and Body Composition in Rheumatoid Arthritis Patients Receiving Tocilizumab TherapyArthritis, RheumatoidDrug: TocilizumabCentre Hospitalier Universitaire de BesanconNULLCompleted18 Years80 YearsAll109Phase 4France
541NCT01768572
(ClinicalTrials.gov)
March 201311/1/2013To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN)A Randomized, Double-Blind, Double-Dummy Study Assessing The Safety and Tolerability of Sarilumab and Tocilizumab In Patients With Rheumatoid Arthritis Who Are Inadequate Responders to or Intolerant of TNF AntagonistsRheumatoid ArthritisDrug: sarilumab SAR153191 (REGN88);Drug: tocilizumab;Drug: hydroxychloroquine;Drug: methotrexate;Drug: sulfasalazine;Drug: leflunomide;Drug: subcutaneous placebo;Drug: intravenous placeboSanofiRegeneron PharmaceuticalsCompleted18 YearsN/AAll202Phase 3United States;Argentina;Belgium;Brazil;Czechia;Estonia;Finland;Hungary;Israel;Italy;Mexico;Netherlands;Norway;Poland;Romania;Russian Federation;Spain;Sweden;United Kingdom;Czech Republic
542NCT01768858
(ClinicalTrials.gov)
February 5, 201314/1/2013Assessment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, Crohn's Disease and Ulcerative Colitis Patients´ Adherence Attitudes to Maintenance Therapy With a Scheduled Adalimumab Treatment in Routine Clinical PracticeAssessment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, Crohn's Disease and Ulcerative Colitis Patients´ Adherence Attitudes to Maintenance Therapy With a Scheduled Adalimumab Treatment in Routine Clinical PracticeRheumatoid Arthritis;Ankylosing Spondylitis;Psoriatic Arthritis;Crohn´s Disease;Ulcerative Colitis;Plaque PsoriasisDrug: AdalimumabAbbVieRaffeiner GmbHCompleted18 Years99 YearsAll96Austria
543NCT01724931
(ClinicalTrials.gov)
February 20137/11/2012Aminopterin Dose Finding Treatment for Methotrexate-Naïve Rheumatoid ArthritisA Phase 2 Double-Blind, Placebo-Controlled, Randomized Dose Finding Study For The Efficacy And Safety Of Aminopterin In Methotrexate-Naive Rheumatoid ArthritisRheumatoid ArthritisDrug: LD-aminopterin;Drug: placeboSyntrix Biosystems, Inc.NULLCompleted18 YearsN/ABoth175Phase 2Ukraine
544NCT01715831
(ClinicalTrials.gov)
January 15, 201325/10/2012A Long-term Safety Extension Study of Tocilizumab in Brazilian Participants With Rheumatoid Arthritis (RA) Who Completed the Studies ML21530 and MA21488A Multicenter, Open-Label, Single-Arm Extension Study to Describe the Safety of Tocilizumab Treatment In Brazilian Patients With DMARDs Refractory Rheumatoid Arthritis Which Completed Studies ML21530 and MA21488 and Presenting an Indication of Maintaining the Tocilizumab TreatmentArthritis, RheumatoidDrug: DMARDs;Drug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll26Phase 4Brazil
545NCT01965132
(ClinicalTrials.gov)
January 1, 201311/10/2013Korean College of Rheumatology Biologics RegistryKorean College of Rheumatology Biologics RegistryRheumatoid Arthritis;Ankylosing Spondylitis;Psoriatic ArthritisDrug: Biologic DMARDSeoul National University HospitalNULLRecruiting18 YearsN/AAll7000Korea, Republic of
546NCT01721044
(ClinicalTrials.gov)
January 20131/11/2012A Moderate to Severe Rheumatoid Arthritis StudyA Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib (LY3009104) in Patients With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Tumor Necrosis Factor InhibitorsRheumatoid ArthritisDrug: Placebo;Drug: Baricitinib;Drug: cDMARDEli Lilly and CompanyNULLCompleted18 YearsN/AAll527Phase 3United States;Argentina;Australia;Austria;Belgium;Canada;Denmark;France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Puerto Rico;Spain;Switzerland;Turkey;United Kingdom;Croatia;India
547NCT01793519
(ClinicalTrials.gov)
January 201314/2/2013Stopping TNF Alpha Inhibitors in Rheumatoid ArthritisStopping Tumor Necrosis Factor-Alpha Inhibitors in Rheumatoid Arthritis (STARA) Clinical TrialRheumatoid ArthritisDrug: Etanercept;Drug: Infliximab;Drug: Adalimumab;Drug: PlaceboGeorgetown UniversityNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS);University of Maryland, College Park;Washington D.C. Veterans Affairs Medical Center;Medstar Health Research Institute;Patient-Centered Outcomes Research Institute;Arthritis and Pain Associates of PG County;Arthritis & Rheumatism Associates, P.C.;Rheumatology Associates of Baltimore, L.L.C.;The Arthritis Clinic of Northern Virginia, P.C.;Arthritis and Rheumatic Disease Associates, P.C.Recruiting18 YearsN/AAll290Phase 4United States
548NCT01765478
(ClinicalTrials.gov)
January 20137/1/2013Safety,PK/PD, Food Effect Study of Orally Administered HM71224 in Healthy Adult Male VolunteersA Phase1 Study, to Determine the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of Single and Multiple Doses of Orally Administered HM71224 in Healthy, Adult Male VolunteersRheumatoid ArthritisDrug: HM71224 single ascending dose;Drug: HM71224 food effect;Drug: HM71224 Multiple ascending doseHanmi Pharmaceutical Company LimitedNULLCompleted18 Years65 YearsMale62Phase 1Netherlands
549NCT01389388
(ClinicalTrials.gov)
January 201316/4/2010Effects of Rosuvastatin on Carotid Artery Plaques in Patients With Inflammatory Joint DiseaseCholesterol Plaques in Carotid and Coronary Arteries and the Effect of Rosuvastatin in Rheumatoid Arthritis, Ankylosing Spondylitis and Other Inflammatory Joint DiseasesCarotid Artery Plaque;Ankylosing Spondylitis;Rheumatoid ArthritisDrug: RosuvastatinDiakonhjemmet HospitalNULLCompleted35 Years80 YearsBoth114N/ANorway
550NCT01754935
(ClinicalTrials.gov)
January 201318/12/2012A Magnetic Resonance Imaging Study and Arthroscopic Biopsy Substudy in Subjects With Active Rheumatoid Arthritis Receiving VX-509, an Oral JAK3 InhibitorA Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of VX-509 Using Magnetic Resonance Imaging and Arthroscopic Biopsies in Subjects With Active Rheumatoid Arthritis on Stable Disease-Modifying Antirheumatic DrugsRheumatoid ArthritisDrug: VX-509;Drug: VX-509 matching placeboVertex Pharmaceuticals IncorporatedNULLCompleted18 Years65 YearsBoth43Phase 2United States;Denmark;Estonia;Lithuania;Netherlands;South Africa
551NCT01721057
(ClinicalTrials.gov)
December 20121/11/2012A Study in Moderate to Severe Rheumatoid Arthritis ParticipantsA Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Baricitinib (LY3009104) in Patients With Inadequate Response to Conventional Disease-Modifying Antirheumatic Drugs With Moderately to Severely Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Placebo;Drug: Baricitinib;Drug: cDMARDEli Lilly and CompanyNULLCompleted18 YearsN/AAll684Phase 3United States;Argentina;Australia;Belgium;Canada;Croatia;Czechia;Germany;Hungary;India;Italy;Japan;Korea, Republic of;Mexico;Poland;Portugal;Puerto Rico;Romania;Russian Federation;Slovakia;Spain;Taiwan;United Kingdom;Czech Republic
552NCT01772316
(ClinicalTrials.gov)
December 201217/1/2013A Long-Term Extension Study of WA22763 and NA25220 of Subcutaneous RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid ArthritisA Multicenter, Open-label, Long-term Extension Study of WA22762 and NA25220 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll47Phase 3Spain
553NCT01770106
(ClinicalTrials.gov)
December 20123/1/2013RA Denosumab on Bone Microstructure StudyComparison of the Effect of Denosumab and Alendronate on Bone Density and Microarchitecture in Rheumatoid Arthritis Females With Low Bone Mass: A Randomized Controlled TrialRheumatoid ArthritisDrug: Denosumab;Drug: AlendronateChinese University of Hong KongNULLCompleted18 Years80 YearsFemale40Phase 4Hong Kong
554NCT01759030
(ClinicalTrials.gov)
December 201220/12/2012Study of Safety and Efficacy of BCD-020 Comparing to MabThera in Patients With Rheumatoid ArthritisDouble Blind Randomized Clinical Study Evaluating Efficacy and Safety of BCD-020 and MabThera in Patients With Rheumatoid Arthritis Who Had an Inadequate Response or Intolerance to Other DMARDs Including One or More TNF Inhibitor TherapiesRheumatoid ArthritisDrug: RituximabBiocadNULLCompleted18 Years80 YearsAll181Phase 3Belarus;India;Russian Federation;Ukraine;Colombia
555NCT01751776
(ClinicalTrials.gov)
December 201214/12/2012Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effects of Multiple Rising Subcutaneous Doses of BI 655064 in Healthy Volunteers and in Rheumatoid Arthritis Patients With Prior Inadequate Response to Methotrexate TherapyA Randomised, Double-blind, Placebo-controlled Trial for Establishing Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Efficacy of Multiple Subcutaneous Doses of BI 655064 in Healthy Volunteers and in Rheumatoid Arthritis Patients With Prior Inadequate Response to Methotrexate TherapyArthritis, Rheumatoid;HealthyDrug: BI 655064 medium dose;Drug: BI 655064 high dose;Drug: Placebo;Drug: BI 655064 low doseBoehringer IngelheimNULLCompleted18 Years70 YearsBoth107Phase 1Czech Republic;Germany;Netherlands;New Zealand;Poland;Spain;Romania
556NCT01717846
(ClinicalTrials.gov)
December 201224/10/2012Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and APC Cells in Rheumatoid ArthritisIn Vivo Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and Antigen Presenting (APC) Cells in Rheumatoid ArthritisApoptotic DNA Damage;Rheumatoid Arthritis;T-cell LymphocytosisDrug: Group 1 or Orencia treated group;Other: Group 2 (DMARDS treated group)University of California, Los AngelesBristol-Myers SquibbWithdrawn18 Years85 YearsBoth0Phase 4United States
557NCT01749787
(ClinicalTrials.gov)
November 20126/12/2012Safety Study of PRTX-100 With Methotrexate or Leflunomide to Treat Active Rheumatoid ArthritisA Phase Ib Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, Dose Escalation, Safety and Tolerability Study of PRTX-100 in Combination With Methotrexate or Leflunomide in Patients With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: PRTX-100 at 1.5 mcg/kg;Drug: PRTX-100 at 3.0 mcg/kg;Drug: PRTX-100 at 6.0 mcg/kg;Drug: PRTX-100 at 12.0 mcg/kg;Drug: PRTX-100 at 240 mcg;Drug: Placebo;Drug: PRTX-100 at 420 mcgProtalex, Inc.NULLCompleted18 YearsN/ABoth61Phase 1United States
558NCT01711359
(ClinicalTrials.gov)
November 201218/10/2012A Study in Participants With Moderate to Severe Rheumatoid ArthritisA Randomized, Double-Blind, Active-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Baricitinib (LY3009104) in Patients With Moderately to Severely Active Rheumatoid Arthritis Who Have Had Limited or No Treatment With Disease-Modifying Antirheumatic DrugsRheumatoid ArthritisDrug: Baricitinib;Drug: Methotrexate;Drug: Baricitinib Placebo;Drug: MTX Placebo;Drug: Folic AcidEli Lilly and CompanyNULLCompleted18 YearsN/AAll588Phase 3United States;Argentina;Austria;Belgium;Brazil;Canada;Germany;Greece;India;Italy;Japan;Korea, Republic of;Mexico;Portugal;Puerto Rico;Russian Federation;South Africa;Sweden;United Kingdom
559NCT01689532
(ClinicalTrials.gov)
November 201218/9/2012A Study of CNTO 136 (Sirukumab) Administered Subcutaneously in Japanese Patients With Active Rheumatoid Arthritis Unresponsive to Methotrexate or SulfasalazineA Multicenter, Randomized, Double-blind, Parallel Group Study of CNTO 136 (Sirukumab), a Human Anti-IL-6 Monoclonal Antibody, Administered Subcutaneously as Monotherapy, in Japanese Subjects With Active Rheumatoid Arthritis Unresponsive to Methotrexate or SulfasalazineArthritis, RheumatoidDrug: Sirukumab 100 mg;Drug: Sirukumab 50 mg;Drug: PlaceboJanssen Pharmaceutical K.K.GlaxoSmithKlineCompleted20 YearsN/AAll122Phase 3Japan
560NCT01725230
(ClinicalTrials.gov)
November 20127/11/2012Assess the Pharmacokinetics of Rosuvastatin and Simvastatin When Administered Alone or in Combination With FostamatinibAn Open-label, Non-randomized, 2-Period, Fixed Sequence, Single-center Study to Assess the Pharmacokinetics of Rosuvastatin and Simvastatin in Healthy Subjects When Administered Alone and in Combination With Fostamatinib 100 mg Twice DailyRheumatoid ArthritisDrug: Fostamatinib;Drug: Rosuvastatin;Drug: SimvastatinAstraZenecaNULLCompleted18 Years55 YearsBoth42Phase 1United States
561NCT01741493
(ClinicalTrials.gov)
November 20123/12/2012A Study in Healthy Adults and Adult Subjects With Rheumatoid Arthritis to Evaluate the Safety, Tolerability and Pharmacokinetics After Multiple Doses of ABT-494A Study in Healthy Adult Volunteers and Adult Subjects With Rheumatoid Arthritis to Evaluate the Safety, Tolerability, and Pharmacokinetics After Multiple Dosing of ABT-494Rheumatoid ArthritisDrug: ABT-494;Drug: Placebo;Drug: TofacitinibAbbVie (prior sponsor, Abbott)NULLCompleted18 Years75 YearsAll67Phase 1United States
562NCT01709760
(ClinicalTrials.gov)
November 201216/10/2012A Phase III Study to Evaluate the Efficacy and Safety of ENIA11 in Combination With Methotrexate Versus Methotrexate Alone in Patients With RAA Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of ENIA11 in Combination With Methotrexate Versus Methotrexate Alone in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Methotrexate;Drug: ENIA11;Drug: PlaceboMycenax Biotech Inc.NULLUnknown status20 YearsN/AAll91Phase 3Taiwan
563NCT01679951
(ClinicalTrials.gov)
October 31, 20123/9/2012A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With MethotrexateA Phase 2b Randomized, Double-blind, Multicenter, Placebo-controlled, Parallel Group, Dose Range Finding Study of JNJ-38518168 in Subjects With Active Rheumatoid Arthritis Despite Concomitant Methotrexate TherapyRheumatoid ArthritisDrug: Placebo;Drug: JNJ-38518168 (3 mg);Drug: JNJ-38518168 (10 mg);Drug: JNJ-38518168 (30 mg);Drug: MethotrexateJanssen Research & Development, LLCNULLTerminated18 Years80 YearsAll272Phase 2United States;Argentina;Chile;Colombia;Czechia;Hungary;Japan;Korea, Republic of;Latvia;Mexico;Poland;Romania;Russian Federation;Taiwan;Thailand;Ukraine;Czech Republic
564NCT01636843
(ClinicalTrials.gov)
October 30, 20126/7/2012A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to MethotrexateA Randomised, Double Blind, Placebo-controlled, Multiple Dose, Phase 2b, 24 Week Trial Followed by an Open Label Extension of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to MethotrexateInflammation;Rheumatoid ArthritisDrug: NNC0109-0012;Drug: placeboNovo Nordisk A/SNULLTerminated18 Years75 YearsAll298Phase 2United States;Argentina;Belgium;Brazil;Czechia;France;Germany;Hungary;Italy;Mexico;Poland;Russian Federation;Spain;Ukraine;Czech Republic
565NCT01590966
(ClinicalTrials.gov)
October 18, 201230/4/2012Scintigraphic Detection of the Biodistribution of Tumor Necrosis Factor With a Radiolabeled Anti-TNFa in Patients With Active Rheumatoid Arthritis and Active Axial and Peripheral SpondyloarthritisScintigraphic Detection of the Biodistribution of Tumor Necrosis Factor With a Radiolabeled Anti-TNFa in Patients With Active Rheumatoid Arthritis and Active Axial and Peripheral SpondyloarthritisAxial and Peripheral Spondyloarthritis;Rheumatoid ArthritisDrug: administration of Cimzia®;Drug: Immunoscintigraphy with radiolabeled Cimzia®.University Hospital, GhentUCB Pharma SACompleted18 Years70 YearsAll41Phase 3Belgium
566NCT01736189
(ClinicalTrials.gov)
October 11, 201227/11/2012Assessment of Clinical Effectiveness and Safety of Adalimumab and High Dose Methotrexate in Routine Clinical PracticeAssessment of Clinical Effectiveness and Safety of Adalimumab and High Dose Methotrexate in Routine Clinical Practice (Combo Study; Adalimumab With High Dose MTX)Rheumatoid ArthritisDrug: AdalimumabAbbVie (prior sponsor, Abbott)NULLCompleted16 Years99 YearsAll346Japan
567NCT01636557
(ClinicalTrials.gov)
October 11, 20126/7/2012A Study to Evaluate the Effect of a Single Dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Patients With Rheumatoid ArthritisA Phase I, Open-label, Drug Interaction Study to Evaluate the Effect of a Single-dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Subjects With Rheumatoid ArthritisArthritis, RheumatoidDrug: Sirukumab;Drug: Midazolam;Drug: Warfarin;Drug: Vitamin K;Drug: Omeprazole;Drug: CaffeineJanssen Research & Development, LLCNULLCompleted18 Years65 YearsAll12Phase 1Germany;Korea, Republic of;Moldova, Republic of;South Africa
568NCT01710358
(ClinicalTrials.gov)
October 201217/10/2012A Study in Moderate to Severe Rheumatoid ArthritisA Randomized, Double-Blind, Placebo- and Active-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib in Patients With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate TherapyRheumatoid ArthritisDrug: Adalimumab;Drug: Baricitinib;Drug: Methotrexate;Drug: Adalimumab Placebo;Drug: Baricitinib PlaceboEli Lilly and CompanyNULLCompleted18 YearsN/AAll1307Phase 3United States;Argentina;Belgium;Canada;China;Croatia;Czechia;France;Germany;Greece;Hungary;Japan;Korea, Republic of;Latvia;Lithuania;Mexico;Poland;Portugal;Puerto Rico;Romania;Russian Federation;Slovakia;Slovenia;South Africa;Spain;Switzerland;Taiwan;United Kingdom;Czech Republic;Netherlands
569NCT01619176
(ClinicalTrials.gov)
October 20125/6/2012Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and BloodNon Inferiority Trial for the Study of Acupuncture on Rheumatoid ArthritisRheumatoid ArthritisDrug: methotrexate;Drug: non-steroidal anti-inflammatory drug (NSAID);Drug: leflunomide;Procedure: AcupunctureChinese Academy of SciencesShanghai GuangHua Hospital of integrated traditional and western medicineCompleted18 Years65 YearsFemale15N/AChina
570NCT01709578
(ClinicalTrials.gov)
October 201215/10/2012To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET)A Randomized, Double-blind, Parallel, Placebo-controlled Study Assessing the Efficacy and Safety of Sarilumab Added to Non-biologic DMARD Therapy in Patients With Rheumatoid Arthritis Who Are Inadequate Responders to or Intolerant of TNF-a AntagonistsRheumatoid ArthritisDrug: Sarilumab;Drug: placebo;Drug: hydroxychloroquine;Drug: methotrexate;Drug: sulfasalazine;Drug: leflunomideSanofiRegeneron PharmaceuticalsCompleted18 YearsN/AAll546Phase 3United States;Argentina;Australia;Austria;Brazil;Canada;Chile;Colombia;Czechia;Ecuador;Germany;Greece;Guatemala;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Mexico;New Zealand;Peru;Poland;Portugal;Romania;Russian Federation;Slovakia;Spain;Taiwan;Turkey;Ukraine;Czech Republic;Hong Kong
571NCT01734993
(ClinicalTrials.gov)
October 201219/11/2012A Long-Term Extension Study of WA22762 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Participants With Moderate to Severe Rheumatoid Arthritis (RA).A Multicenter, Open-Label Long-Term Extension Study of WA22762 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll11Phase 3France
572NCT02915094
(ClinicalTrials.gov)
October 201223/9/2016Kineret in the Treatment of Rheumatoid ArthritisKineret in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: AnakinraSwedish Orphan BiovitrumNULLCompleted18 YearsN/AAll30N/AGermany
573NCT01871961
(ClinicalTrials.gov)
October 201214/5/2013Evaluation of Patient Performance Using the Metoject Device for Subcutaneous Injection in Rheumatoid Arthritis (RA)PatientEvaluation of Rheumatoid Arthritis Patient Performance Using the Metoject® Prefilled Pen (Methotrexate 50 mg/mL, Prefilled Pen) for Subcutaneous Injection and Subsequent Pharmacokinetic Assessment of Drug DeliveryRheumatoid Arthritis (RA)Drug: Methotrexate (Metoject® prefilled pen)medac GmbHPPD (CRO)Completed16 YearsN/ABoth105Phase 1United States
574NCT01730456
(ClinicalTrials.gov)
October 201215/11/2012A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Early Moderate to Severe Rheumatoid Arthritis Who Completed Study WA19926A MULTICENTER, OPEN-LABEL, SINGLE ARM, LONG TERM EXTENSION STUDY OF WA19926 TO DESCRIBE SAFETY DURING TREATMENT WITH TOCILIZUMAB IN PATIENTS WITH EARLY, MODERATE TO SEVERE RHEUMATOID ARTHRITISRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/ABoth13Phase 3Macedonia, The Former Yugoslav Republic of
575NCT01711814
(ClinicalTrials.gov)
September 26, 201219/10/2012A Study to Evaluate the Long-term Safety and Efficacy of ASP015K in Subjects Previously Enrolled in a Phase 2 ASP015K Rheumatoid Arthritis StudyA Phase 2 Open-Label, Noncomparative, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of ASP015K in Subjects Previously Enrolled in a Phase 2 ASP015K Rheumatoid Arthritis StudyArthritis, RheumatoidDrug: peficitinibAstellas Pharma Global Development, Inc.Janssen Biotech, Inc.Completed18 YearsN/AAll611Phase 2United States;Belgium;Bulgaria;Colombia;Czechia;Hungary;Mexico;Poland;Czech Republic
576NCT01850966
(ClinicalTrials.gov)
September 12, 20128/5/2013Investigation of the Safety and Efficacy of Iguratimod in Patients With Rheumatoid ArthritisInvestigation of the Safety and Efficacy of Iguratimod in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: IguratimodEisai Co., Ltd.NULLCompletedN/AN/AAll2747Japan
577NCT01682512
(ClinicalTrials.gov)
September 5, 201210/8/2012Efficacy, Pharmacokinetics, and Safety of BI 695500 in Patients With Rheumatoid ArthritisEfficacy, Pharmacokinetics, and Safety of BI 695500 Versus Rituximab in Patients With Moderately to Severely Active Rheumatoid Arthritis: a Randomized, Double-blind, Parallel Arm, Multiple Dose, Active Comparator Trial.Arthritis, RheumatoidDrug: BI 695500;Drug: Rituxan®;Drug: MabThera®Boehringer IngelheimNULLTerminated18 Years80 YearsAll294Phase 3United States;Argentina;Belgium;Bulgaria;Canada;Chile;Germany;Greece;Hungary;Ireland;Mexico;Netherlands;Poland;Portugal;Spain;Ukraine;United Kingdom;Brazil;Estonia;France;Guatemala;Italy;New Zealand;Norway;Peru;Russian Federation;Serbia;South Africa;Sweden
578NCT01694264
(ClinicalTrials.gov)
September 1, 201224/9/2012Study of Anti-Viral Prophylaxis for HBsAg(+) or HBcAb(+)/HBsAb(-) Patients Starting Anti-TNFaA Randomized, Double-blinded, Phase 3, Multicenter, Investigator-initiated Trial for Entecavir for Prophylaxis of Hepatitis B Virus (HBV) Reactivation in HBV Surface Antigen or Anti-HBc Positive Patients Undergoing Anti-TNFa TreatmentChronic Hepatitis B;Rheumatoid Arthritis;Ankylosing Spondylitis;Psoriatic Arthritis;Juvenile Idiopathic ArthritisDrug: Entecavir;Drug: PlaceboSeoul National University HospitalKonkuk University Medical Center;Kyungpook National University;Kyunghee University Medical Center;Kyung Hee University Hospital at Gangdong;Gachon University Gil Medical Center;Daegu Catholic University Medical Center;Eulji University Hospital;SMG-SNU Boramae Medical Center;The Catholic University of Korea;Severance Hospital;Ajou University School of Medicine;Ewha Womans University Mokdong Hospital;Inha University Hospital;Chonnam National University Hospital;Chonbuk National University Hospital;Chungnam National University Hospital;Hallym University Medical Center;Hanyang University;Dong-A University;Korea University Guro HospitalTerminated16 Years85 YearsAll43Phase 3Korea, Republic of
579NCT01676701
(ClinicalTrials.gov)
September 201229/8/2012Evaluation of Tabalumab Using Auto-Injector or Prefilled Syringe in Participants With Rheumatoid Arthritis (RA)Pharmacokinetic Evaluations of Tabalumab Following Subcutaneous Administration by Prefilled Syringe or Auto Injector in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Tabalumab Auto-Injector;Drug: Tabalumab Prefilled SyringeEli Lilly and CompanyNULLTerminated18 YearsN/AAll8Phase 3United States;Argentina;Czechia;Poland;Puerto Rico;Russian Federation;Czech Republic
580NCT01635686
(ClinicalTrials.gov)
September 20124/7/2012Comparison the Safety and Pharmacokinetic Characteristics of DWP422 25 mg With Those of ENBREL 25MG PFS INJ. After Subcutaneous Injection in Healthy Male VolunteersA Randomized, Double-blind, Single-dosing, Crossover Study to Compare the Safety and Pharmacokinetic Characteristics of DWP422 25 mg With Those of ENBREL 25MG PFS INJ. After Subcutaneous Injection in Healthy Male VolunteersRheumatoid ArthritisDrug: DWP422 25mg;Drug: ENBREL 25MG PFS INJ.Daewoong Pharmaceutical Co. LTD.NULLNot yet recruiting20 Years45 YearsMale38Phase 1Korea, Republic of
581NCT01647451
(ClinicalTrials.gov)
September 201219/7/2012A Randomised, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy of NNC0114-0006 in Subjects With Active Rheumatoid ArthritisA Randomised, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy of NNC0114-0006 in Subjects With Active Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC0114-0006;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsAll62Phase 2Bulgaria;Hungary;Latvia;Poland;Russian Federation;Serbia;Spain
582NCT01661140
(ClinicalTrials.gov)
September 20127/8/2012A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Severe Active Rheumatoid Arthritis, Comparing Tapering Versus Maintaining the Methotrexate DosageRandomized, Phase IV, Placebo-controlled, Comparative Study to Evaluate the Efficacy and Safety of Tapering Methotrexate (MTX) Dosage Versus Maintaining the Dosage in Patients With Severe Active Rheumatoid Arthritis (RA) Who Have Demonstrated an Inadequate Response (IR) to Prior Disease-modifying Anti-rheumatic Drugs (DMARDs) Treatment and Have Initiated RoActemra (RoActemra, TCZ) in Combination With MTXRheumatoid ArthritisDrug: Methotrexate (stable dose);Drug: Tocilizumab;Drug: Methotrexate (tapering dose)Hoffmann-La RocheNULLTerminated18 YearsN/AAll427Phase 4United Kingdom
583NCT04704492
(ClinicalTrials.gov)
August 14, 20126/1/2021A Study of the Pharmacokinetics and Safety of SM03 in Patients With Rheumatoid ArthritisAn Open-label, Multiple-dose Study to Assess the Pharmacokinetics, Pharmacodynamics, Preliminary Clinical Activity and Safety of Human Mouse Chimeric Anti-CD22 Monoclonal Antibody (SM03) in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Biological: SM03SinoMab Pty LtdNULLCompleted18 Years65 YearsAll8Phase 1China
584NCT01606761
(ClinicalTrials.gov)
August 6, 201224/5/2012A Study of CNTO 136 (Sirukumab), a Human Anti-IL-6 Monoclonal Antibody, Administered Subcutaneously, in Patients With Active Rheumatoid Arthritis Despite Anti-TNF-Alpha Therapy (SIRROUND-T)A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study of CNTO 136 (Sirukumab), a Human Anti-IL-6 Monoclonal Antibody, Administered Subcutaneously, in Subjects With Active Rheumatoid Arthritis Despite Anti-TNF-Alpha TherapyArthritis, RheumatoidDrug: Placebo;Drug: SirukumabJanssen Research & Development, LLCGlaxoSmithKlineCompleted18 YearsN/AAll878Phase 3United States;Argentina;Australia;Austria;Belgium;Canada;Croatia;France;Germany;Japan;Korea, Republic of;Lithuania;Mexico;Netherlands;New Zealand;Poland;Portugal;Puerto Rico;Russian Federation;Spain;Taiwan;United Kingdom;Brazil;China
585NCT01645280
(ClinicalTrials.gov)
August 20126/6/2012A Study of the Effectiveness and Safety of Ustekinumab (STELARA) and CNTO 1959 Administered Under the Skin of Patients With Active Rheumatoid Arthritis, Despite Existing Methotrexate TherapyA Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Study Evaluating the Efficacy and Safety of Ustekinumab (STELARA®) and CNTO 1959 Administered Subcutaneously in Subjects With Active Rheumatoid Arthritis Despite Concomitant Methotrexate TherapyArthritis, RheumatoidDrug: Placebo + methotrexate (MTX) (Group 1);Drug: Ustekinumab + MTX (Group 2);Drug: Ustekinumab + MTX (Group 3);Drug: CNTO 1959 + MTX (Group 4);Drug: CNTO 1959 + MTX (Group 5)Janssen Research & Development, LLCNULLCompleted18 Years80 YearsAll274Phase 2United States;Argentina;Bulgaria;Chile;Colombia;Czech Republic;Hungary;Poland;Russian Federation;Singapore;Ukraine;Korea, Republic of;Mexico;Peru;Turkey
586NCT01636817
(ClinicalTrials.gov)
August 20126/7/2012A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Anti-TNFa BiologicsA Randomised, Double Blind, Placebo-controlled, Multiple Dose, Phase 2b, 24 Week Trial Followed by an Open Label Extension of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Anti-TNFa BiologicsInflammation;Rheumatoid ArthritisDrug: NNC0109-0012;Drug: placeboNovo Nordisk A/SNULLTerminated18 Years75 YearsAll239Phase 2United States;Argentina;Belgium;Brazil;Czechia;France;Germany;Hungary;Italy;Mexico;Poland;Spain;United Kingdom;Czech Republic
587NCT01870908
(ClinicalTrials.gov)
August 20124/6/2013Special Drug Use-Results Survey of Prograf Capsule in Rheumatoid Arthritis PatientsDrug Use-result Survey to Assess the Safety and Efficacy of the Combination of Tacrolimus + Biological Agents in Daily Clinical SettingsRheumatoid ArthritisDrug: tacrolimus;Drug: biological agentsAstellas Pharma IncNULLCompletedN/AN/ABoth664N/AJapan
588NCT01662063
(ClinicalTrials.gov)
August 201230/7/2012A Long-Term Extension Study of WA22762 and NA25220 of Subcutaneous (SC) Tocilizumab (TCZ) in Moderate to Severe Rheumatoid Arthritis (RA)A Multicenter Open-Label, Long-Term Extension Study of WA22762 and NA25220 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: TocilizumabGenentech, Inc.NULLCompleted18 YearsN/AAll218Phase 3United States;Puerto Rico
589NCT01651936
(ClinicalTrials.gov)
August 201225/7/2012A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Trial to Evaluate the Safety, Tolerability, and Efficacy of MK-8457 in Participants With Rheumatoid Arthritis (MK-8457-010)A Phase IIa, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Worldwide, Proof-of-Concept Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of MK-8457 in Subjects With Active Rheumatoid Arthritis and an Inadequate Response or Intolerance to Anti-TNF-a TherapyRheumatoid ArthritisDrug: MK-8457 100 mg;Drug: Methotrexate;Drug: Dose-match placeboMerck Sharp & Dohme Corp.NULLTerminated18 YearsN/AAll56Phase 2Australia;Colombia;Denmark;France;Greece;Hungary;Italy;Korea, Republic of;New Zealand;Poland;South Africa;Spain;United Kingdom;United States
590NCT01604343
(ClinicalTrials.gov)
August 201221/5/2012A Study of CNTO 136 (Sirukumab), Administered Subcutaneously, in Patients With Active Rheumatoid Arthritis Despite Disease-Modifying Antirheumatic Drug (DMARD) Therapy (SIRROUND-D)A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study of CNTO 136 (Sirukumab), a Human Anti-IL-6 Monoclonal Antibody, Administered Subcutaneously, in Subjects With Active Rheumatoid Arthritis Despite DMARD TherapyArthritis, RheumatoidDrug: Placebo;Drug: SirukumabJanssen Research & Development, LLCGlaxoSmithKlineCompleted18 YearsN/ABoth1670Phase 3United States;Bulgaria;Canada;Chile;Colombia;Croatia;Japan;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Romania;Russian Federation;Serbia;South Africa;Taiwan;Ukraine;Argentina;Brazil;India;Peru
591NCT01746680
(ClinicalTrials.gov)
August 20124/12/2012Efficacy and Safety Study of Tacrobell to Treat Rheumatoid ArthritisPhase IV STudy of Tacrobell in Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Tacrolimus with MethotrexateChong Kun Dang PharmaceuticalNULLCompleted20 YearsN/ABoth111Phase 4Korea, Republic of
592NCT01652937
(ClinicalTrials.gov)
August 201219/7/2012BIIB057 in Subjects With Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic DrugsA Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Efficacy of BIIB057 in Subjects With Rheumatoid Arthritis Who Have Had an Inadequate Response to Disease-Modifying Antirheumatic DrugsRheumatoid ArthritisDrug: BIIB057;Drug: PlaceboBiogen IdecNULLWithdrawn18 YearsN/AFemale0Phase 2Canada
593NCT01705730
(ClinicalTrials.gov)
July 31, 201210/10/2012A Non-Interventional Study of Rheumatoid Arthritis Patients Treated With RoActemra/Actemra (Tocilizumab) in MonotherapyMon-ACT: A Multi-center, Non-interventional Study in Rheumatoid Arthritis (RA) Patients Treated With Tocilizumab in MonotherapyRheumatoid ArthritisDrug: tocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll71Belgium
594NCT01554696
(ClinicalTrials.gov)
July 6, 201213/3/2012A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Subjects Who Have Had an Inadequate Response to MethotrexateA Phase 2b, Randomized, Double-blind, Parallel-group, Placebo Controlled, Dose-finding, Multi-center Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis in Patients Who Have Had an Inadequate Response to MethotrexateArthritis, RheumatoidDrug: peficitinib;Drug: Placebo;Drug: methotrexateAstellas Pharma IncNULLCompleted18 YearsN/AAll379Phase 2United States;Belgium;Bulgaria;Colombia;Czechia;Hungary;Mexico;Poland;Czech Republic
595NCT01597739
(ClinicalTrials.gov)
July 201210/5/2012A Study of JNJ-40346527 in Patients With Active Rheumatoid Arthritis Despite Disease-modifying Antirheumatic Drug TherapyA Phase 2a, Randomized, Multicenter, Double-blind, Placebo-controlled, Parallel-group Study of JNJ-40346527 in Subjects With Active Rheumatoid Arthritis Despite Disease-modifying Antirheumatic Drug TherapyArthritis, RheumatoidDrug: JNJ-40346527;Drug: PlaceboJanssen Research & Development, LLCNULLCompleted18 Years80 YearsBoth96Phase 2Argentina;Bulgaria;Chile;Czech Republic;Hungary;Korea, Republic of;Poland;Russian Federation;Singapore;Ukraine
596NCT01649804
(ClinicalTrials.gov)
July 201223/7/2012A Long-Term Safety Extension Study of WA19926 in Participants With Rheumatoid ArthritisA MULTICENTER, OPEN-LABEL, SINGLE ARM, LONG-TERM EXTENSION STUDY OF WA19926 TO DESCRIBE SAFETY DURING TREATMENT WITH TOCILIZUMAB IN PATIENTS WITH EARLY, MODERATE TO SEVERE RHEUMATOID ARTHRITISRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll12Phase 3Hungary
597NCT01659242
(ClinicalTrials.gov)
July 20123/8/2012Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging StudyLeflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis Patients With Active Disease Despite Methotrexate: an Ultrasound and Magnetic Resonance Imaging StudyRheumatoid ArthritisDrug: Methotrexate plus sulfasalazine;Drug: LeflunomideSingapore General HospitalNULLTerminated21 Years65 YearsBoth1Phase 4Singapore
598NCT01578850
(ClinicalTrials.gov)
July 201212/4/2012Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to ScreeningA Randomized, Double-blind Placebo-controlled Study Of The Maintenance Of Efficacy Of Etanercept Plus Dmard(s) Compared With Dmard(s) Alone In Subjects With Rheumatoid Arthritis After Achieving An Adequate Response With Etanercept Plus Dmard(s)Rheumatoid ArthritisDrug: Etanercept;Drug: placeboPfizerNULLCompleted18 Years70 YearsAll491Phase 4Brazil;China;Colombia;Czech Republic;Egypt;Hungary;Jordan;Lebanon;Malaysia;Mexico;Philippines;Qatar;Romania;Russian Federation;South Africa;Taiwan;Thailand;Ukraine;United Arab Emirates;Saudi Arabia
599NCT01793259
(ClinicalTrials.gov)
July 201214/2/2013Preference Methotrexate (MTX) Pre-filled Syringe Versus Pre-filled Pen in Rheumatoid Arthritis (RA)An Open-label, Randomized, Two-period Cross-over Study of Repeated Subcutaneous Injections of Methotrexate 50mg/ml Solution Either by a Pre-filled Syringe (Reference) or by a Disposable Pre-filled Pen (Test) to Assess Patient's Preference and Self-injection Experience and to Compare the Local Tolerability in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: methotrexate prefilled pen;Drug: methotrexate prefilled syringemedac GmbHNULLCompleted18 Years75 YearsBoth120Phase 3Germany
600NCT01665430
(ClinicalTrials.gov)
July 201213/8/2012A Long-Term Extension Study to WA19926 (NCT01007435) of Tocilizumab in Participants With Early, Moderate to Severe Rheumatoid ArthritisA Multicenter, Open-Label, Single Arm, Long-Term Extension Study of WA19926 to Describe Safety During Treatment With Tocilizumab in Patients With Early, Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLTerminated18 YearsN/AAll38Phase 3Poland
601NCT01640054
(ClinicalTrials.gov)
July 20122/7/2012A Long Term Study to Assess the Safety of Fostamatinib in Patients in Asia With Rheumatoid Arthritis(OSKIRA-Asia-1X): A Long-term Study to Assess the Safety of Fostamatinib in the Treatment of Rheumatoid Arthritis in AsiaRheumatoid ArthritisDrug: FostamatinibAstraZenecaNULLTerminated18 YearsN/AAll115Phase 2Hong Kong;Japan;Korea, Republic of;Taiwan;Thailand;Vietnam
602NCT01893151
(ClinicalTrials.gov)
July 20122/7/2013Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRIA Randomized, Double-blind Study to Evaluate the Efficacy of Iguratimod Versus Placebo in Patients With Rheumatoid Arthritis on Magnetic Resonance Imaging (MRI)Rheumatoid ArthritisDrug: Iguratimod;Drug: Iguratimod placeboJiangsu Simcere Pharmaceutical Co., Ltd.NULLRecruiting18 Years65 YearsBoth200Phase 4China
603NCT01565655
(ClinicalTrials.gov)
June 19, 201227/3/2012A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid ArthritisA Phase 2b, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Dose-Finding, Multi-Center Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis PatientsArthritis, RheumatoidDrug: peficitinib;Drug: PlaceboAstellas Pharma Global Development, Inc.NULLCompleted18 YearsN/AAll289Phase 2United States;Bulgaria;Czechia;Hungary;Mexico;Poland;Czech Republic
604NCT01638013
(ClinicalTrials.gov)
June 13, 20129/7/2012A Study to Continue ASP015K Treatment to Rheumatoid Arthritis Patients Who Completed Phase IIb Study or Phase III Study of ASP015KOpen-label Extension Study in Rheumatoid Arthritis Patients Who Have Completed Phase 2b Study or Phase 3 Study of ASP015KArthritis, RheumatoidDrug: PeficitinibAstellas Pharma IncNULLCompleted20 YearsN/AAll843Phase 3Japan;Korea, Republic of;Taiwan
605NCT01611688
(ClinicalTrials.gov)
June 4, 20121/6/2012First Human Dose Trial of NNC0215-0384 in Subjects With Rheumatoid ArthritisFirst Human Dose Trial of NNC0215-0384 in Subjects With Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC0215-0384;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsAll36Phase 1Germany
606NCT02015520
(ClinicalTrials.gov)
June 20126/12/2013Phase IIB Dose Ranging Study in Subjects With Moderate to Severe Rheumatoid ArthritisA Phase IIb, Randomized, Multi-Center, Double-Blind, Dose-Ranging Study to Evaluate the Efficacy and Safety of Clazakizumab in Subjects With Moderate to Severe Active Rheumatoid Arthritis Who Have Experienced an Inadequate Response to TNF InhibitorsRheumatoid ArthritisDrug: Clazakizumab;Drug: Placebo (Matching with Clazakizumab)CSL BehringNULLCompleted18 YearsN/AAll143Phase 2United States;Argentina;Canada;France;Hungary;Italy;Japan;Mexico;South Africa;Australia
607NCT01602302
(ClinicalTrials.gov)
June 201216/5/2012Ultrasound and Withdrawal of Biological DMARDs in Rheumatoid ArthritisUltrasound as Biomarker for Withdrawal of Biological DMARDs in Rheumatoid ArthritisRheumatoid ArthritisDrug: bDMARD withdrawal (etanercept, adalimumab, infliximab, certolizumab, golimumab, tozilizumab, abatacept)Medical University of GrazNULLTerminated18 Years90 YearsAll40Phase 4Austria
608NCT02052375
(ClinicalTrials.gov)
June 201230/1/2014A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With Rheumatoid Arthritis on MethotrexateA Phase 1, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Subcutaneous Injections in Patients With Rheumatoid Arthritis on MethotrexateRheumatoid Arthritis;Pharmacokinetics of ASP2408Drug: ASP2408;Drug: PlaceboAstellas Pharma Global Development, Inc.NULLCompleted18 Years75 YearsBoth24Phase 1United States
609NCT01664104
(ClinicalTrials.gov)
June 20127/8/2012A Study to Evaluate Tocilizumab Treatment in a Real-Life SettingCRP and BMI Study: Evaluation in Real Life of Clinical Remission Rate and Correlation Between CRP and BMI in Patients Treated With TocilizumabRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll151N/AItaly
610NCT01569152
(ClinicalTrials.gov)
May 22, 201230/3/2012Safety and Efficacy of MK-8457 and Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Despite MTX Therapy (P08683, MK-8457-008)A Phase II, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Worldwide, Dose-Ranging Clinical Trial With a Proof-of-Concept Lead Cohort to Evaluate the Safety, Tolerability, and Efficacy of MK-8457 + MTX in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyRheumatoid Arthritis (RA)Drug: MK-8457 100 mg;Drug: Dose-Matched Placebo;Drug: MethotrexateMerck Sharp & Dohme Corp.NULLTerminated18 YearsN/AAll82Phase 2Canada;Chile;Denmark;Germany;Hungary;Japan;Korea, Republic of;Lithuania;Moldova, Republic of;Peru;Poland;South Africa;Taiwan;United Kingdom;United States
611NCT01664598
(ClinicalTrials.gov)
May 201210/8/2012An Extension Study of WA19926 of the Long-Term Safety of RoActemra/Actemra (Tocilizumab) in Patients With Early Moderate to Severe Rheumatoid ArthritisA Multicenter, Open-label, Single Arm, Long Term Extension Study of WA19926 to Describe Safety During Treatment With Tocilizumab in Patients With Early, Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/ABoth49Phase 3Russian Federation
612NCT01724268
(ClinicalTrials.gov)
May 20127/11/2012Corticosteroids and Anti TNF in Methotrexate Inadequate Responder Rheumatoid Arthritis PatientRandomized Controlled Clinical Trial of Low Dose Corticosteroids vs Anti TNF Treatment in Methotrexate Inadequate Responder Rheumatoid Arthritis Patient- a Pilot StudyRHEUMATOID ARTHRITISDrug: Pred + Meth;Drug: Anti TNF + MethHamad Medical CorporationNULLRecruiting18 YearsN/ABoth80Phase 3Qatar
613NCT01638715
(ClinicalTrials.gov)
May 20123/7/2012A Randomized, Multi-Center Biomarker Trial to Predict Therapeutic Responses of Patients With Rheumatoid Arthritis to a Specific Biologic Mode of ActionA Randomized, Multi-Center Biomarker Trial to Predict Therapeutic Responses of Patients With Rheumatoid Arthritis to a Specific Biologic Mode of ActionRheumatoid ArthritisDrug: Remicade;Drug: Orencia;Drug: Ro-Actemra;Drug: MabtheraMedical University of ViennaNULLCompleted18 Years75 YearsAll115Phase 4Austria;Czechia;Russian Federation;Switzerland;Czech Republic;Saudi Arabia
614NCT01548001
(ClinicalTrials.gov)
May 20125/3/2012Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid ArthritisA Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Iguratimod Alone or Iguratimod in Combination With Methotrexate Versus Methotrexate Alone in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Iguratimod;Drug: MethotrexateJiangsu Simcere Pharmaceutical Co., Ltd.NULLActive, not recruiting18 Years65 YearsBoth910Phase 4China
615NCT01668641
(ClinicalTrials.gov)
May 201214/8/2012Dose-ranging Study With GLPG0634 in Methotrexate-refractory Active Rheumatoid Arthritis PatientsRandomized, Double-blind, Placebo-controlled, Multicenter, Phase II Study to Compare Four Dose Regimens of GLPG0634 Versus Placebo, in Combination With Methotrexate, Administered for 4 Weeks in the Treatment of Subjects With Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate AloneRheumatoid ArthritisDrug: GLPG0634;Drug: PlaceboGalapagos NVNULLCompleted18 Years70 YearsBoth91Phase 2Hungary;Moldova, Republic of;Russian Federation;Ukraine
616NCT01576549
(ClinicalTrials.gov)
May 201210/4/2012A Study of LY2127399 in Rheumatoid ArthritisAn Exploratory Open-Label Biomarker Study of LY2127399 in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Synovial BiopsiesRheumatoid ArthritisDrug: LY2127399Eli Lilly and CompanyNULLTerminated18 YearsN/AAll2Phase 2United States
617NCT01617005
(ClinicalTrials.gov)
May 20128/6/2012A Study of Tocilizumab in Participants With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Non-Biological Disease-modifying Anti-rheumatic Drugs (DMARDs)Non-interventional Local Study to Describe the Safety, Tolerability and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-biologic DMARDRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll50N/AMontenegro
618NCT01579006
(ClinicalTrials.gov)
May 201216/4/2012Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid ArthritisA Multi National, Multi-center Non-interventional Study in Rheumatoid Arthritis (RA) Patients Treated With Tocilizumab (Actemra)Rheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheClalit Health ServicesCompleted18 YearsN/AAll184N/AIsrael
619NCT01617590
(ClinicalTrials.gov)
May 201228/5/2012Disease-Modifying Antirheumatic Drugs Cycle Combination Therapy ResearchA 48-week, Multi-center, Randomized, Open-lable, Controlled Study to Assess the Response (ACR20) Using Different Disease-Modifying Antirheumatic Drugs Cycle Combination Regimen in Adult Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: leflunomide;Drug: methotrexateShanxi Medical UniversityNULLRecruiting18 Years75 YearsBoth500N/AChina
620NCT01613079
(ClinicalTrials.gov)
May 20124/6/2012Efficacy and Safety of Tripterygium Wilfordii in Patients With Rheumatoid ArthritisEvaluation of Oral T2 (Chloroform/Methanol Extract of Tripterygium Wilfordii Hook F) in the Treatment of RA Patients With Clinical Efficacy and Safety.Arthritis, RheumatoidDrug: Tripterygium wilfordii Hook F;Drug: MethotrexatePeking Union Medical College HospitalNULLCompleted18 Years65 YearsBoth201Phase 2/Phase 3China
621NCT01554917
(ClinicalTrials.gov)
May 201212/3/2012A Study of Iguratimod in Patients With Active Rheumatoid ArthritisA Phase IV Study of Iguratimod in Patients With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: IguratimodJiangsu Simcere Pharmaceutical Co., Ltd.NULLCompleted18 YearsN/AAll1759Phase 4China
622NCT01618968
(ClinicalTrials.gov)
May 20124/6/2012Comparison of Methotrexate (MTX) and the VIBEX™ MTX DeviceExposure, Safety and Local Tolerance Study Comparing the Relative Bioavailability of Oral Methotrexate and the VIBEX™ MTX Device in Adult Subjects With Rheumatoid ArthritisRheumatoid Arthritis (RA)Drug: MTXAntares Pharma Inc.NULLCompleted18 YearsN/AAll49Phase 2United States
623NCT02818361
(ClinicalTrials.gov)
April 201215/6/2016Topical Tripterygium Wilfordii Gel for Moderate Activity Rheumatoid ArthritisTopical Tripterygium Wilfordii Gel for Treatment in Patients With Moderate Activity Rheumatoid ArthritisArthritis, RheumatoidDrug: Topical tripterygium gel;Drug: Placebo gelGuang'anmen Hospital of China Academy of Chinese Medical SciencesNULLCompleted18 Years65 YearsAll70N/AChina
624NCT01590459
(ClinicalTrials.gov)
April 201227/4/201224-week Study With Open Label Extension of VX-509, an Oral JAK3 Inhibitor, in Subjects Taking MethotrexateA 24-week, Double-Blind, Randomized, Parallel Group, Placebo-Controlled, Phase 2 Study of Different Doses of VX-509 in Adult Subjects With Active Rheumatoid Arthritis on Stable Methotrexate Therapy With 104-Week Open Label ExtensionRheumatoid ArthritisDrug: VX-509;Drug: VX-509 matching placeboVertex Pharmaceuticals IncorporatedNULLCompleted18 Years80 YearsBoth359Phase 2United States;Argentina;Bulgaria;Czech Republic;Estonia;Germany;Hungary;Mexico;Poland;Romania;Russian Federation;Serbia;Slovakia;Ukraine
625NCT01563978
(ClinicalTrials.gov)
April 201223/3/2012Study of the Effect of Fostamatinib Twice Daily on Blood Pressure in Patients With Rheumatoid ArthritisOSKIRA-ABPM: A Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of the Effect of Fostamatinib 100 mg Twice Daily on 24-hour Ambulatory Blood Pressure in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: fostamatinib;Drug: placeboAstraZenecaNULLCompleted18 YearsN/AAll266Phase 2United States;Bulgaria;Czech Republic;Germany;Poland;South Africa;Ukraine;Argentina;Mexico;Peru
626NCT01569074
(ClinicalTrials.gov)
April 201230/3/2012Evaluation of Safety and Effectiveness of Fostamatinib Compared to Placebo in Patients in Asia With Rheumatoid Arthritis(OSKIRA-Asia-1): A Multi-centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Dose Ranging Study in Asia Evaluating Efficacy and Safety of Fostamatinib in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Methotrexate TherapyRheumatoid ArthritisDrug: Fostamatinib;Drug: PlaceboAstraZenecaNULLTerminated18 YearsN/AAll163Phase 2Hong Kong;Japan;Korea, Republic of;Taiwan;Thailand;Vietnam
627NCT02171143
(ClinicalTrials.gov)
April 201218/6/2014A Dose Escalation Study to Assess Safety, Tolerability and Pharmacokinetics of ASP2409 Following a Single Intravenous Dose in Patients With Rheumatoid Arthritis on MethotrexateA Phase 1, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP2409 Following a Single Intravenous Dose in Patients With Rheumatoid Arthritis on MethotrexateRheumatoid Arthritis;Pharmacokinetics of ASP2409Drug: ASP2409;Drug: PlaceboAstellas Pharma Global Development, Inc.NULLCompleted18 Years75 YearsBoth58Phase 1United States
628NCT01557374
(ClinicalTrials.gov)
April 201216/3/2012TOward the Lowest Effective DOse of Abatacept or TocilizumabTapering Abatacept or Tocilizumab in Rheumatoid Arthritis in Remission. An Evaluation of Disease Activity, Relapse Risk, Structural Progression and the Economic Impact of a Tapering StrategyRheumatoid ArthritisDrug: Tocilizumab, Abatacept;Drug: Decrease Tocilizumab, AbataceptAssistance Publique - Hôpitaux de ParisMinistry of Health, FranceCompleted18 YearsN/AAll232Phase 4France
629NCT01583959
(ClinicalTrials.gov)
April 201215/3/2012Study of Different Doses of Folic Acid in Combination With Methotrexate in Rheumatoid ArthritisRandomized Trial of 10 mg Versus 30 mg Per Week of Folic Acid in Combination With Methotrexate in Rheumatoid ArthritisRheumatoid ArthritisDrug: Folic Acid;Drug: PlaceboPostgraduate Institute of Medical Education and ResearchNULLCompleted18 Years75 YearsBoth100Phase 4India
630NCT01484561
(ClinicalTrials.gov)
April 201230/11/2011A Study To Evaluate The Effect Of CP-690,550 On Measures Of Kidney Function In Patients With Active Rheumatoid ArthritisA Phase 1, Randomized, Placebo-Controlled, Two-Period, Fixed Sequence Study To Evaluate The Effect Of CP-690,550 On Measured Glomerular Filtration Rate In Patients With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: CP-690,550 or Placebo;Drug: PlaceboPfizerNULLCompleted18 YearsN/AAll148Phase 1United States;Czech Republic;Germany;Korea, Republic of;Mexico;Poland;Russian Federation;Spain
631NCT01579890
(ClinicalTrials.gov)
April 201216/4/2012Compassionate Use of Pennsaid Topical Lotion (Diclofenac) in Osteo or Rheumatoid ArthritisA Non-blinded, Non-placebo Controlled, Compassionate Use, Open Treatment, Open-ended Program of the Safety of Pennsaid Topical Lotion (Diclofenac) in the Treatment of Osteo or Rheumatoid ArthritisOsteoarthritis of the HandDrug: DiclofenacMallinckrodtNuvo Research Inc.Approved for marketingN/AN/ABothN/ANULL
632NCT01655381
(ClinicalTrials.gov)
April 201230/7/2012A Long-Term Extension Study of WA19926 on the Safety of Tocilizumab (RoActemra/Actemra) in Participants With Early Moderate to Severe Rheumatoid ArthritisA Multicenter, Open-label, Single Arm, Long-term Extension Study of WA19926 to Describe Safety During Treatment With Tocilizumab in Patients With Early, Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll15Phase 3France
633NCT01649999
(ClinicalTrials.gov)
March 1, 201223/7/2012A Study to Evaluate the Efficacy and Safety of ASP015K in Moderate to Severe Rheumatoid Arthritis SubjectsPhase 2b Study of ASP015K - A Double-Blind, Placebo-Controlled, Dose-Finding Study in Moderate to Severe Rheumatoid Arthritis PatientsArthritis, RheumatoidDrug: peficitinib;Drug: PlaceboAstellas Pharma IncNULLCompleted20 Years75 YearsAll281Phase 2Japan
634NCT01612377
(ClinicalTrials.gov)
March 201222/2/2012Long Term Safety Trial of z102 and Prednisone in Patients With Moderate to Severe Rheumatoid ArthritisA Phase II, Double-blind, Controlled, Multi-center, Randomized, Long Term Safety Trial of z102 and Prednisone (5 mg or 7.5 mg) in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: Prednisolone-Dipyridamole;Drug: Prednisone;Drug: prednisoneZalicusNULLTerminated18 YearsN/ABoth18Phase 2Serbia
635NCT01670045
(ClinicalTrials.gov)
March 201217/8/2012A Non-Interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid ArthritisA Multi-national, Multi-center Non-interventional Study in Rheumatoid Arthritis (RA) Patients Treated With TocilizumabRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll43N/AIndonesia;Greece
636NCT01582880
(ClinicalTrials.gov)
March 201210/4/2012Use of Cross-linked Donor Corneas as Carriers for the Boston KeratoprosthesisThe Use of Riboflavin/Ultraviolet A Cross-linked Human Donor Corneas as Carriers for the Boston KeratoprosthesisChemical Injuries;Unspecified Complication of Corneal Transplant;Autoimmune Diseases;Ocular Cicatricial Pemphigoid;Stevens Johnson Syndrome;Lupus Erythematosus, Systemic;Rheumatoid Arthritis;Other Autoimmune DiseasesDrug: RiboflavinJoseph B. Ciolino, MDNULLCompleted18 YearsN/AAll1Phase 1/Phase 2United States
637NCT01626573
(ClinicalTrials.gov)
March 20123/5/2012A Study Exploring the Safety, Tolerability, and Efficacy of a 28 Day Course Followed by an Additional 56 Day Course of Itacitinib in Subjects With Active Rheumatoid ArthritisA Double- Blind, Placebo Controlled Study Exploring the Safety, Tolerability, and Efficacy of a 28 Day Course Followed by an Additional 56 Day Course of Itacitinib in Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Itacitinib;Drug: Itacitinib PlaceboIncyte CorporationNULLCompleted18 Years75 YearsAll106Phase 2United States;Puerto Rico
638NCT01565408
(ClinicalTrials.gov)
March 201221/3/2012Safety and Tolerability of NNC0114-0006 at Increasing Dose Levels in Subjects With Rheumatoid ArthritisSafety and Tolerability of NNC0114-0006 Following Multiple s.c. Dosing at Escalating Dose Levels in Subjects With Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC0114-0006;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsAll32Phase 1Germany;Russian Federation
639NCT01940926
(ClinicalTrials.gov)
February 20129/9/201368Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid ArthritisDiagnostic Performance and Evaluation Efficacy of 68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: 68Ga-BNOTA-PRGD2Peking Union Medical College HospitalNULLUnknown status18 YearsN/AAll50Early Phase 1China
640NCT01395251
(ClinicalTrials.gov)
February 201212/7/2011Diagnostic Value of Oral Prednisolone Test for Rheumatoid ArthritisPhase II/III Study of Oral Prednisolone Test in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: PrednisoloneRheumazentrum RuhrgebietNULLCompleted18 YearsN/ABoth130Phase 2/Phase 3Germany
641NCT01587989
(ClinicalTrials.gov)
February 201212/3/2012A Study of RoActemra/Actemra (Tocilizumab) With or Without Methotrexate in Patients With Mild to Moderate Rheumatoid Arthritis With an Inadequate Response to MethotrexateA Multi-center Study of the Safety and Effect on Disease Activity of Tocilizumab (TCZ) in Combination With Methotrexate (MTX) Versus Tocilizumab Monotherapy in Patients With Mild to Moderate Rheumatoid Arthritis, With Inadequate Response to MTX (Defined as DAS 28 < 4,5 and >2,6)Rheumatoid ArthritisDrug: methotrexate;Drug: placebo;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll77Phase 3Austria
642NCT01562327
(ClinicalTrials.gov)
February 201221/3/2012A Non-interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid ArthritisA Multi-national, Multi-center Non-interventional Study in Rheumatoid Arthritis (RA) Patients Treated With Tocilizumab ActemraRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll50N/AArgentina
643NCT01646385
(ClinicalTrials.gov)
February 201212/4/2012Study to Assess the Safety and Efficacy of Etanercept in Patients Treated Over the Long-term in Real-world Clinical Practice, Using Data Collected by the British Society of Rheumatology Biologics RegistryLong-term Safety and Efficacy of Etanercept in a UK Observational Cohort Study - a Retrospective Database Analysis of British Society of Rheumatology Biologics Registry (BSRBR) DataRheumatoid ArthritisDrug: etanercept;Drug: non-biologic anti-rheumatic drugsPfizerNULLCompleted18 YearsN/AAll6393N/ANULL
644NCT01352858
(ClinicalTrials.gov)
February 201211/5/2011Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis (AutoDECRA)Phase 1 Study of Autologous Tolerogenic Dendritic Cells for Rheumatoid ArthritisRheumatoid ArthritisDrug: TolDC;Drug: Arthroscopy & saline irrigation aloneNewcastle UniversityArthritis Research UK;Newcastle-upon-Tyne Hospitals NHS TrustUnknown status18 YearsN/AAll15Phase 1United Kingdom
645NCT01438892
(ClinicalTrials.gov)
February 201220/9/2011Impact Of RA Therapy Compliance On Patient-Reported OutcomesImpact Of RA Therapy Compliance On Patient-Reported OutcomesRheumatoid ArthritisDrug: tDMARDs;Drug: biodmardsPfizerNULLCompleted18 YearsN/ABoth396N/AUnited States
646NCT01623752
(ClinicalTrials.gov)
February 201218/6/2012Prospective Evaluation of the Radiographic Efficacy of EnbrelA PROSPECTIVE EVALUATION OF THE RADIOGRAPHIC EFFICACY OF ETANERCEPT IN PATIENTS WITH RHEUMATOID ARTHRITIS OR PSORIATIC ARTHRITIS.Rheumatoid Arthritis;Psoriasis ArthritisDrug: EtanerceptPfizerNULLCompleted18 YearsN/AAll1821NULL
647NCT02090556
(ClinicalTrials.gov)
January 31, 201219/2/2014Long-term Experience With Abatacept SC in Routine Clinical PracticeLong-term Experience With Abatacept SC in Routine Clinical PracticeRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbinVentiv Health Clinical;PharmaNetUnknown status18 YearsN/AAll2896Australia;Austria;France;Germany;Greece;Italy;Monaco;Netherlands;Spain;Switzerland;United Kingdom
648NCT02922192
(ClinicalTrials.gov)
January 1, 201228/9/2016Incidence of Hospitalizations for Serious Infections in Patients Receiving Biologic Anti-Inflammatories for Rheumatologic, Psoriatic, and Gastrointestinal Conditions: A Descriptive AnalysisIncidence of Hospitalizations for Serious Infections in Patients Receiving Biologic Anti-Inflammatories for Rheumatologic, Psoriatic, and Gastrointestinal Conditions: A Descriptive AnalysisRheumatoid Arthritis;Inflammatory Bowel Disease;Psoriasis;Psoriatic Arthritis;Ankylosing SpondylitisDrug: TNF-a antagonists, non-TNFs, DMARD non-biologicsBiologics & Biosimilars Collective Intelligence ConsortiumHealthCore, Inc.;Aetna, Inc.;University of Alabama; Rheumatologist and Healthcare Research;AbbVie;Amgen;Boehringer Ingelheim;Kaiser Permanente;Harvard Pilgrim Health Care;Merck Sharp & Dohme Corp.;Momenta Pharmaceuticals, Inc.;Pfizer;University of PittsburghCompleted18 YearsN/AAll90360NULL
649NCT01506661
(ClinicalTrials.gov)
January 20125/1/2012Safety of Zostavax Vaccination in Rheumatoid ArthritisImmune Response to Varicella Zoster Vaccination (ZOSTAVAX) in Subjects With Rheumatoid ArthritisRheumatoid Arthritis;Varicella ZosterDrug: Zostavax (varicella zoster virus) vaccineOklahoma Medical Research FoundationNULLCompleted50 Years80 YearsAll20Phase 1United States
650NCT01511003
(ClinicalTrials.gov)
December 5, 20114/1/2012A Study is to Assess Efficacy and Safety of Tacrolimus in Active Rheumatoid Arthritis Patients Who Showed Unsuccessful Response to Existing Disease Modifying Antirheumatic Drugs (DMARDs)An Open- Label, Single-arm, Phase 4 Study to Assess the Efficacy and Safety of Tacrolimus in Active Rheumatoid Arthritis Patients Shown Unsuccessful Response Against DMARDsRheumatoid ArthritisDrug: TacrolimusAstellas Pharma IncAstellas Pharma Korea, Inc.Completed20 Years75 YearsAll128Phase 4Korea, Republic of
651NCT01480388
(ClinicalTrials.gov)
December 201123/11/2011A Dose Range Finding Study of JNJ-39758979 in Patients With Active Rheumatoid Arthritis Currently Treated With MethotrexateA Phase 2b Randomized, Double-blind, Multicenter, Placebo-controlled, Parallel-group, Dose Range Finding Study of JNJ-39758979 in Subjects With Active Rheumatoid Arthritis Despite Concomitant Methotrexate TherapyActive Rheumatoid Arthritis; Rheumatoid ArthritisDrug: Placebo/JNJ-39758979 (300 mg/d);Drug: JNJ-39758979 (10 mg);Drug: JNJ-39758979 (30 mg);Drug: JNJ-39758979 (100 mg);Drug: JNJ-39758979 (300 mg)Janssen Research & Development, LLCNULLWithdrawn18 Years80 YearsBoth0Phase 2United States
652NCT01326962
(ClinicalTrials.gov)
November 30, 20117/3/2011A Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs or Anti-TNFTocilizumab Efficacy and Safety in RA Patients After Inadequate Response to DMARDs or Anti-TNFRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll28Phase 3Saudi Arabia
653NCT01592292
(ClinicalTrials.gov)
November 201111/4/2012An Observational Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis And Inadequate Response Or Intolerance to a First Anti-TNF Alpha TherapyA Non-interventional Study for Relative Efficacy Outcome of Rituximab Treatment in RA Patients Who Have Inadequate Response or Have Been Intolerant to a First Anti-TNF AgentRheumatoid ArthritisDrug: Rituximab;Drug: Adalimumab;Drug: Etanercept;Drug: InfliximabHoffmann-La RocheNULLCompleted20 YearsN/AAll90N/AKorea, Republic of
654NCT01251120
(ClinicalTrials.gov)
November 201130/11/2010A Study of RoActemra/Actemra (Tocilizumab) in Combination With DMARDs Versus Current Best Practice DMARD Therapy in Patients With Rheumatoid ArthritisA Pragmatic, Randomized, Parallel Group Study of the Effect on Disease Remission, Work Productivity and Tolerability of Tocilizumab in Combination With DMARDs and Individually Designed Best Practice DMARD Therapy in Patients With Early, Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: DMARDHoffmann-La RocheNULLTerminated18 YearsN/AAll2Phase 4Finland
655NCT01468077
(ClinicalTrials.gov)
November 20117/11/2011A Study in Patients With Moderate to Severe Active Rheumatoid Arthritis Comparing Different Infusion Durations of RoActemra/Actemra (Tocilizumab) TreatmentMulticenter, Randomized, Parallel Group Study to Compare the Incidence of Tocilizumab Related Infusion Reactions in Patients With Moderate to Severe Active RA, When Infusion is Given Over 31 Minutes Compared to 1 HourRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll47Phase 2Denmark;Iceland
656NCT01469013
(ClinicalTrials.gov)
November 20118/11/2011Oral Baricitinib (LY3009104)Treatment in Japanese Participants With Active Rheumatoid Arthritis on Background Methotrexate TherapyA Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Parallel-Group, Phase 2 Study of Baricitinib (LY3009104) in Japanese Patients With Active Rheumatoid Arthritis on Background Methotrexate TherapyArthritis, RheumatoidDrug: Placebo;Drug: Baricitinib;Drug: MethotrexateEli Lilly and CompanyNULLCompleted20 Years75 YearsAll145Phase 2Japan
657NCT01408602
(ClinicalTrials.gov)
November 20112/8/2011A Study of Two Doses of MRC375 in Moderate to Severe Rheumatoid Arthritis PatientsA 24-week, Phase 2, Double-blind, Placebo-controlled, Randomized Study to Assess the Safety and Efficacy of 2 Doses of MRC375 in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: MRC375;Drug: Matching Placebo;Drug: MRC375 150mgMolecular Research Center, Inc.Camargo Pharmaceutical Services;Clin Data Services;Harrison Clinical Research;BARC Global Central Laboratory;Bilcare Global Clinical SuppliesActive, not recruiting18 YearsN/ABoth300Phase 2United States
658NCT01451203
(ClinicalTrials.gov)
October 11, 201125/9/2011Efficacy Confirmation Study of CDP870 in Early Rheumatoid ArthritisA Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Assess the Efficacy and Safety of CDP870 in Patients With Early-stage Rheumatoid Arthritis Who Are Naïve to Methotrexate and Have Poor Prognostic FactorsRheumatoid ArthritisDrug: Placebo;Drug: CZP;Drug: methotrexate (MTX)Astellas Pharma IncUCB Japan Co. Ltd.Completed20 Years64 YearsAll319Phase 3Japan
659NCT01548768
(ClinicalTrials.gov)
October 10, 20116/3/2012RHYTHM (Formerly Escape II Myocardium)RHYTHM (RHeumatoid Arthritis studY of THe Myocardium): How Rheumatoid Arthritis (RA) and Tumor Necrosis Factor (TNF) Inhibitors Affect the Myocardial Structure and Function.Rheumatoid ArthritisDrug: TNF inhibitors;Drug: DMARDsColumbia UniversityNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed18 YearsN/AAll149Phase 4United States
660NCT01292616
(ClinicalTrials.gov)
October 20118/2/2011Effect of TNF-Inhibition Combined With Conventional DMARDs on Cervical Pannus in Patients With RA and Cervical Spine InvolvementRheumatoid ArthritisDrug: therapy with disease-modifying anti rheumatic drugs (DMARD)University of ZurichNULLRecruiting18 YearsN/ABoth15N/ASwitzerland
661NCT01641952
(ClinicalTrials.gov)
October 201113/7/2012An Observational Study of MabThera/Rituxan (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response or Intolerance to One Anti-Tumor Necrosis Factor (Anti-TNF) AgentNon-interventional, Prospective, Multicenter Study to Assess Efficacy and Safety of MabtheRA (Rituximab) in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response or Intolerance to One Anti-TNF Agent - FAST 2 SWITCH ProgramRheumatoid ArthritisDrug: RituximabHoffmann-La RocheNULLCompleted18 YearsN/AAll505N/ARomania
662NCT01961505
(ClinicalTrials.gov)
October 201123/9/2013Topical Compound Tripterygium Wilfordii Hook F for Patients With Active Rheumatoid ArthritisA Randomized Controlled Study to Determine the Effects and Safety of Topical Compound Tripterygium Wilfordii Hook F in Patients With Active Rheumatoid Arthritis.Active Rheumatoid ArthritisDrug: Topical compound tripterygium;Drug: PlaceboGuang'anmen Hospital of China Academy of Chinese Medical SciencesNULLCompleted18 Years65 YearsAll70N/ANULL
663NCT04169100
(ClinicalTrials.gov)
September 28, 201114/11/2019Novel Form of Acquired Long QT SyndromeNovel Form of Acquired Long QT SyndromeLong QT Syndrome;Connective Tissue Diseases;Rheumatoid ArthritisDrug: PrednisoneNarrows Institute for Biomedical ResearchVA New York Harbor Healthcare SystemRecruiting18 Years89 YearsAll25Phase 4United States
664NCT01359150
(ClinicalTrials.gov)
September 201111/5/2011A Study To Assess the Immune Response Following Administration Of Influenza and Pneumococcal Vaccines To Subjects With Rheumatoid Arthritis Receiving CP-690,550 Or PlaceboA Randomized, Double Blind, Placebo Controlled Phase 2 Study To Assess The Immune Response Following Administration Of Influenza And Pneumococcal Vaccines To Subjects With Rheumatoid Arthritis Receiving Cp-690,550 Or Placebo Cp-690,550 With And Without Background MethotrexateRheumatoid ArthritisDrug: CP-690,550;Drug: placeboPfizerNULLCompleted18 YearsN/AAll223Phase 2United States;Poland
665NCT01374971
(ClinicalTrials.gov)
September 201114/6/2011Rheumatoid Arthritis Treatment and Biopsy Study Assessing Certolizumab Pegol (Cimzia)Open-Label Pre and Post Treatment Arthroscopic Synovial Biopsy Study for the Assessment of Certolizumab Pegol Immunomodulatory Synovial Effects on Select Biomarkers and Gene ExpressionRheumatoid ArthritisDrug: Certolizumab Pegol (CZP);Procedure: Arthroscopic synovial tissue biopsyNathan Wei, MD, FACP, FACR:University of California, San DiegoCompleted18 YearsN/AAll12Phase 3United States
666NCT01393639
(ClinicalTrials.gov)
September 201113/6/2011Study Comparing Doses Of An Experimental Glucocorticoid Compound To Prednisone And Placebo In Rheumatoid ArthritisA Phase 2, Randomized, Double Blind Assessment Of Efficacy And Safety Of Pf 04171327(1, 5, 10, 15 Mg Dose, Daily) Compared To 5 Mg And 10 Mg Prednisone Daily And Placebo Daily In Subjects With Rheumatoid Arthritis Over An 8 Week Period Followed By A 4 Week Period Of Tapering Of Study Drug.Rheumatoid ArthritisDrug: PF-04171327;Drug: prednisone;Other: prednisone;Other: placeboPfizerNULLCompleted18 YearsN/AAll323Phase 2United States;Bulgaria;Colombia;Czechia;Germany;Hungary;India;Korea, Republic of;Malaysia;Mexico;Poland;Romania;Russian Federation;Serbia;Slovakia;South Africa;Spain;Ukraine;Canada;Czech Republic
667NCT01462162
(ClinicalTrials.gov)
September 201127/10/2011A Prospective Observational Study of Tocilizumab (RoActemra/Actemra) in Participants With Rheumatoid ArthritisA Prospective Observational Study to Evaluate and Correlate the Impact of Treatment With Tocilizumab (RoActemra®) on Fatigue and Different Factors Influencing Fatigue in Participants With Rheumatoid Arthritis in Routine Clinical PracticeRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll122N/ASpain
668NCT01399697
(ClinicalTrials.gov)
September 201120/7/2011A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateA Multi-center Study of the Safety and Effect on Disease Activity of Tocilizumab (TCZ) in Combination With MTX Versus Tocilizumab Monotherapy in Patients With Rheumatoid Arthritis, With Inadequate Response to MTX (Defined as DAS 28 > 3,2)Rheumatoid ArthritisDrug: methotrexate;Drug: placebo;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll261Phase 4Spain
669NCT01404585
(ClinicalTrials.gov)
September 201127/7/2011Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid ArthritisA Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of BMS-817399 in Adults With Active, Moderate to Severe Rheumatoid Arthritis and Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Placebo;Drug: BMS-817399Bristol-Myers SquibbNULLCompleted18 YearsN/ABoth123Phase 2United States;Argentina;Korea, Republic of;Mexico;Russian Federation;South Africa;Spain
670NCT01245439
(ClinicalTrials.gov)
September 201117/11/2010A Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid ArthritisLocal Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis on Background Non-biologic DMARDs Who Have an Inadequate Response to Current Non-biologic DMARDRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll65Phase 3Turkey
671NCT02076659
(ClinicalTrials.gov)
September 201124/2/2014Combination Therapy of F8IL10 and Methotrexate in Rheumatoid Arthritis PatientsA Dose-finding, Pharmacokinetic Phase I Study of the Human Monoclonal Antibody-cytokine Fusion Protein F8IL10 (Dekavil) in Combination With Methotrexate in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: F8IL10;Drug: MethotrexatePhilogen S.p.A.NULLCompleted18 Years75 YearsAll36Phase 1Italy
672NCT01430507
(ClinicalTrials.gov)
September 20117/9/2011A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid ArthritisA Phase IIb, 12 Week Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Evaluate Efficacy, Safety and Tolerability of Revamilast in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Revamilast;Drug: Placebo ComparatorGlenmark Pharmaceuticals Ltd. IndiaGlenmark Pharmaceuticals S.A.Completed18 Years65 YearsBoth406Phase 2India;Philippines;Poland;Sri Lanka;United Kingdom
673NCT01417052
(ClinicalTrials.gov)
September 201112/8/2011A Study to Determine the Safety and Efficacy of LX3305 in Subjects With Active Rheumatoid ArthritisA Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Study to Determine the Safety and Efficacy of Daily Orally Administered LX3305 in Subjects With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: 50 mg LX3305 QD;Drug: 100 mg LX3305 QD;Drug: 150 mg LX3305 QD;Drug: 200 mg LX3305 QD;Drug: 250 mg LX3305 QD;Drug: 300 mg LX3305 QD;Drug: 400 mg LX3305 QD;Drug: 250 mg LX3305 BID;Drug: 500 mg LX3305 QD;Drug: PlaceboLexicon PharmaceuticalsNULLCompleted18 Years75 YearsBoth10Phase 1United States
674NCT02164214
(ClinicalTrials.gov)
September 20114/7/2013Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?DOES ETANERCEPT INFLUENCE TWEAK MODULATION OF INFLAMMATION DURING INFLAMMATORY RHEUMATISMS (PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS)?Inflammatory Rheumatism;Psoriatic Arthritis;Rheumatoid ArthritisDrug: etanercept TreatmentAssistance Publique Hopitaux De MarseilleNULLCompleted18 YearsN/ABoth60Phase 3France
675NCT01331837
(ClinicalTrials.gov)
August 2, 20117/4/2011A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk FactorsA Clinical Outcomes Study to Evaluate the Effects of IL-6 Receptor Blockade With Tocilizumab (TCZ) in Comparison With Etanercept (ETA) on the Rate of Cardiovascular Events in Patients With Moderate to Severe Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Etanercept;Drug: TocilizumabHoffmann-La RocheNULLCompleted50 YearsN/AAll3080Phase 4United States;Argentina;Austria;Belgium;Bosnia and Herzegovina;Canada;Chile;Croatia;Czechia;Ecuador;France;Germany;Greece;Hungary;India;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Philippines;Poland;Romania;Russian Federation;Serbia;South Africa;Spain;Turkey;United Kingdom;Brazil;China;Czech Republic
676NCT01400516
(ClinicalTrials.gov)
August 201121/7/2011Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA TrialTeriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA TrialRheumatoid ArthritisDrug: Teriparatide;Drug: calcium citrate;Drug: Vitamin D;Drug: TNF antagonistBrigham and Women's HospitalEli Lilly and CompanyCompleted45 YearsN/AAll26Phase 4United States
677NCT01295151
(ClinicalTrials.gov)
August 201111/2/2011SWITCH Clinical Trial for Patients With Rheumatoid Arthritis Who Have Failed an Initial TNF-blocking Drug.Randomised-controlled Trial of Switching to Alternative Tumour-necrosis Factor (TNF)-Blocking Drugs or Abatacept or Rituximab in Patients With Rheumatoid Arthritis Who Have Failed an Initial TNF-blocking DrugRheumatoid ArthritisDrug: Etanercept;Drug: Abatacept;Biological: Rituximab;Drug: Adalimumab;Drug: Certolizumab Pegol;Drug: Infliximab;Drug: GolimumabJulia BrownNULLCompleted18 YearsN/ABoth122Phase 4United Kingdom
678NCT01414101
(ClinicalTrials.gov)
August 201121/7/2011Safety, Tolerability, and Pharmacodynamic Study of ISIS CRP Rx in Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Phase 2 Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ISIS 329993 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: ISIS CRP Rx or PlaceboIsis PharmaceuticalsNULLCompleted18 Years75 YearsBoth51Phase 2Canada;Russian Federation
679NCT01426789
(ClinicalTrials.gov)
August 201112/8/2011A Biomarker Study of Secukinumab in Rheumatoid Arthritis (RA) PatientsA Multicenter, 12 Week, Randomized, Double-blind, Placebo-controlled Biomarker Study of Secukinumab (AIN457) in Rheumatoid Arthritis Patients Followed by an Open Label ExtensionRheumatoid ArthritisDrug: Placebo;Drug: SecukinumabNovartis PharmaceuticalsNULLCompleted18 YearsN/AAll100Phase 2United States;Belgium;Germany;Russian Federation;United Kingdom
680NCT01390545
(ClinicalTrials.gov)
August 20115/7/2011VELVET, a Dose Range Finding Trial of Veltuzumab in Subjects With Moderate to Severe Rheumatoid ArthritisVELVET (Veltuzumab Various Doses Exploratory Trial), a Randomized, Double Blind, Placebo Controlled, Multicentre, Multinational Phase II Dose Range Finding Trial in Subjects With Moderate to Severe Rheumatoid Arthritis Insufficiently Controlled With Either Methotrexate Alone or Methotrexate Plus Anti-tumour Necrosis Factor Biological Treatment, Comparing 3 Different Subcutaneous Dosages of Anti-CD20 Monoclonal Antibody Veltuzumab to Placebo as an add-on Therapy to Methotrexate.Rheumatoid ArthritisDrug: VeltuzumabTakedaNULLTerminated18 YearsN/ABoth300Phase 2United States;Argentina;Canada;Czech Republic;Germany;Hungary;Italy;Mexico;Poland;Spain;United Kingdom
681NCT01442545
(ClinicalTrials.gov)
August 201123/8/2011A Study to Investigate How JNJ-39758979 May Affect the Plasma Levels of Methotrexate in Rheumatoid Arthritis ParticipantsA Study to Investigate the Effect of Multiple Doses of JNJ 39758979 on Methotrexate Pharmacokinetics in Rheumatoid Arthritis Patients on a Stable Methotrexate DoseRheumatoid ArthritisDrug: JNJ-39758979 / MTXJohnson & Johnson Pharmaceutical Research & Development, L.L.C.NULLCompleted18 Years75 YearsBoth21Phase 1United States;Germany
682NCT01382940
(ClinicalTrials.gov)
July 26, 201124/6/2011A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid ArthritisA Multicenter, Open-label, Single-arm Study to Evaluate the Safety Administering Rituximab at a More Rapid Infusion Rate in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: rituximab;Drug: methotrexate;Drug: methylprednisolone;Drug: acetaminophen;Drug: antihistamineHoffmann-La RocheNULLCompleted18 YearsN/AAll351Phase 4United States
683NCT01410695
(ClinicalTrials.gov)
July 20114/8/2011Masitinib in Refractory Active Rheumatoid ArthritisA 24-week With Possible Extension, Prospective, Multicenter, Randomised, Double-blind, Controlled, 3-parallel Groups, Phase 2b/3 Study to Compare Efficacy and Safety of Masitinib at 3 and 6 mg/kg/Day to Methotrexate, With a Randomisation 1:1:1, in Treatment of Patients With Active Rheumatoid Arthritis With Inadequate Response to 1. Methotrexate or to 2. Any DMARD Including at Least One Biologic Drug if Patients Previously Failed Methotrexate or to 3. Methotrexate in Combination With Any DMARD Including Biologic DrugsRheumatoid Arthritis (RA)Drug: masitinib 3 mg;Drug: masitinib 6.0 mg;Drug: methotrexate;Drug: Placebo (methotrexate);Drug: Placebo (masitinib)AB ScienceNULLTerminated18 YearsN/AAll324Phase 2/Phase 3Czechia;Czech Republic;France;United States
684NCT02433184
(ClinicalTrials.gov)
July 201123/4/2015Very Early Versus Delayed Etanercept in Patients With RAA Prospective, Single-centre, Randomised Study Evaluating the Clinical, Imaging and Immunological Depth of Remission Achieved by Very Early Versus Delayed Etanercept in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Etanercept;Drug: Methotrexate;Drug: Sulfasalazine;Drug: HydroxychloroquineUniversity of LeedsNULLCompleted18 Years80 YearsAll120Phase 4United Kingdom
685NCT01405118
(ClinicalTrials.gov)
June 20117/7/2011Effect Of CP-690,550 On The Pharmacokinetics Of Metformin In Healthy VolunteersA Phase 1, Open Labeled, Fixed Sequence Study To Estimate The Effect Of CP-690,550 On The Pharmacokinetics Of Metformin In Healthy VolunteersRheumatoid ArthritisDrug: Metformin/CP-690,550PfizerNULLCompleted18 Years55 YearsBoth24Phase 1Belgium
686NCT01373151
(ClinicalTrials.gov)
June 201113/6/2011Phase IIB Rheumatoid Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to MethotrexateA Phase IIB , Randomized, Multi-Center, Double-Blind, Dose-Ranging, Placebo/Active Controlled Study to Evaluate the Efficacy and Safety of BMS-945429 Subcutaneous Injection With or Without Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Methotrexate.Rheumatoid ArthritisDrug: BMS-945429 Placebo;Biological: BMS-945429;Drug: Methotrexate;Drug: Methotrexate Placebo;Drug: Adalimumab Placebo;Drug: AdalimumabCSL BehringNULLCompleted18 YearsN/AAll418Phase 2United States;Argentina;Belgium;Brazil;Canada;Czechia;France;Germany;Hungary;Italy;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Russian Federation;South Africa;Spain;Taiwan;Czech Republic;Peru
687NCT01450982
(ClinicalTrials.gov)
June 201113/6/2011A Study to Investigate How JNJ-38518168 May Affect the Plasma Levels of Methotrexate in Rheumatoid Arthritis ParticipantsA Study to Investigate the Effects of JNJ-38518168 on Methotrexate Pharmacokinetics in Rheumatoid Arthritis Participants on a Stable Methotrexate DoseRheumatoid ArthritisDrug: JNJ-38518168 / MTXJohnson & Johnson Pharmaceutical Research & Development, L.L.C.NULLCompleted18 Years75 YearsBoth20Phase 1United States
688NCT01384422
(ClinicalTrials.gov)
June 201127/6/2011Safety and Preliminary Efficacy of GLPG0634 in Methotrexate-refractory Active Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: GLPG0634Galapagos NVNULLCompleted18 Years70 YearsBoth36Phase 2Moldova, Republic of
689NCT01369745
(ClinicalTrials.gov)
June 20117/6/2011A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid ArthritisA Phase II, Double-Blind, Placebo-Controlled, Multi-Center, Randomized Withdrawal Design Trial Using Adaptive Randomization Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: Prednisolone;Drug: dipyridamole;Drug: Prednisone;Drug: Z102;Other: placeboZalicusNULLCompleted18 YearsN/AAll294Phase 2United States
690NCT01215942
(ClinicalTrials.gov)
June 20115/10/2010An Open Label Study for Participants With Rheumatoid ArthritisA Phase 3b, Multicenter, Open-Label Study to Evaluate the Long-Term Safety and Efficacy of LY2127399 in Patients With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: LY2127399Eli Lilly and CompanyNULLTerminated18 YearsN/AAll1086Phase 3United States;Argentina;Australia;Brazil;Bulgaria;Colombia;Croatia;France;Germany;Greece;Hungary;India;Japan;Korea, Republic of;Lithuania;Malaysia;Mexico;New Zealand;Poland;Romania;Russian Federation;Slovakia;South Africa;Spain;Sri Lanka;Taiwan;Ukraine;Italy;Peru
691NCT01355354
(ClinicalTrials.gov)
June 201117/5/2011Effects of Administration of Fostamatinib on Blood Concentrations of Digoxin in Healthy SubjectsAn Open-Label, Non-Randomised, 2-Period, Single Centre Study to Assess the Pharmacokinetics of Digoxin in Healthy Subjects When Administered Alone and in Combination With Fostamatinib 100 mg Twice DailyHealthy Volunteers;Rheumatoid ArthritisDrug: Digoxin;Drug: FostamatinibAstraZenecaNULLCompleted18 Years45 YearsBoth21Phase 1United Kingdom
692NCT01329991
(ClinicalTrials.gov)
May 20114/4/2011Phase 1b Study of PLX5622 in Rheumatoid Arthritis Patients Who Are Receiving MethotrexateA Phase 1b Study to Assess Safety, Pharmacokinetics, Pharmacodynamics, and Drug-Drug Interaction of PLX5622 in Patients With Rheumatoid Arthritis Who Are Receiving MethotrexateRheumatoid ArthritisDrug: PLX5622;Drug: PlaceboPlexxikonNULLCompleted18 YearsN/ABoth26Phase 1United States
693NCT01328522
(ClinicalTrials.gov)
May 201131/3/2011Comparison of the Safety and Pharmacokinetics of Two SAR153191 (REGN88) Drug Products in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: SAR153191 (REGN88)SanofiRegeneron PharmaceuticalsCompleted18 Years75 YearsBoth32Phase 1United States
694NCT01404429
(ClinicalTrials.gov)
May 201126/7/2011Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid ArthritisRandomized Controlled Trial of Two Different Starting Doses of Methotrexate in Rheumatoid ArthritisRheumatoid ArthritisDrug: MethotrexatePostgraduate Institute of Medical Education and ResearchNULLCompleted18 Years65 YearsAll100Phase 4India
695NCT01262118
(ClinicalTrials.gov)
May 201115/11/2010Effects Of CP-690,550 (Tasocitinib) On Cholesterol Metabolism In Patients With Active Rheumatoid ArthritisAn Exploratory Phase 1, Fixed Sequence, Open-Label Study To Assess The Effects Of CP-690,550 On The Kinetics Of Cholesterol Flux Through The High Density Lipoprotein/Reverse Cholesterol Transport Pathway In Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CP-690,550 (tasocitinib)PfizerNULLCompleted18 YearsN/AAll69Phase 1United States;Hungary
696NCT01416493
(ClinicalTrials.gov)
May 201111/8/2011Bovine Intestinal Alkaline Phosphatase (bIAP) Modulating Rheumatoid ArthritisAn OPEN LABEL Phase II Safety Study of Bovine Intestinal Alkaline Phosphatase (bIAP), an Inflammation Modulating Moiety, in RA PatientsAcute Rheumatoid ArthritisDrug: s.c. injections of bovine intestinal Alkaline PhosphataseAlloksys Life Sciences B.V.Aix ScientificsCompleted18 YearsN/ABoth6Phase 1/Phase 2United Kingdom
697NCT01347983
(ClinicalTrials.gov)
May 20113/5/2011Extension Study of Tocilizumab Long Term Treatment of Moderate to Severe Rheumatoid Arthritis PatientsExtension Study of Tocilizumab Long Term Treatment of Moderate to Severe Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Tocilizumab+Methotrexate(MTX)Chugai Pharma TaiwanNULLCompleted20 Years75 YearsBoth72Phase 3Taiwan
698NCT01370902
(ClinicalTrials.gov)
May 201131/5/2011Safety and Tolerability of NNC0141-0000-0100 in Subjects With Rheumatoid ArthritisA Randomised, Double-blind, Placebo-controlled, Single-dose and Multiple-dose, Dose-escalation Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0141-0000-0100 in Subjects With Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC 0141-0000-0100;Drug: placeboInnate PharmaNULLCompleted18 Years75 YearsBoth92Phase 1Germany
699NCT01283971
(ClinicalTrials.gov)
May 201125/1/2011A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate (MTX) in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One Tumor Necrosis Factor (TNF)-InhibitorA Randomized, Open-label, Parallel-group Study of the Reduction of Signs and Symptoms During Treatment With Tocilizumab Versus Adalimumab, Both in Combination With MTX, in Patients With Moderate to Severe Active Rheumatoid Arthritis and an Inadequate Response to Treatment With Only One TNF InhibitorRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: adalimumab;Drug: placebo to tocilizumab;Drug: placebo to adalimumab;Drug: methotrexate;Drug: folateHoffmann-La RocheNULLTerminated18 YearsN/AAll96Phase 4United States;Denmark;Finland;France;Germany;Greece;Italy;Netherlands;Puerto Rico;Russian Federation;Spain;Sweden;United Kingdom
700NCT01336218
(ClinicalTrials.gov)
April 201114/4/2011Effects of Administration of Fostamatinib on Blood Concentrations of Rifampicin in Healthy Subjects.An Open-Label, Non-Randomized, 2-Period, Single Center Study to Assess the Single Dose Pharmacokinetics of R406 in Healthy Subjects When Fostamatinib 150 mg is Administered Alone and in Combination With RifampicinRheumatoid Arthritis;Healthy VolunteersDrug: fostamatinib;Drug: rifampicinAstraZenecaNULLCompleted18 Years55 YearsBoth15Phase 1United States
701NCT01313520
(ClinicalTrials.gov)
March 1, 201125/2/2011A Study to Evaluate the Effectiveness of Infliximab and Changes in Hand and Wrist Magnetic Resonance Imaging (MRI) in Participants With Active Rheumatoid Arthritis (RA) (P08136)A Randomized Clinical Trial to Study the Effects of Infliximab on Clinical Efficacy and Hand and Wrist Magnetic Resonance Imaging (MRI) in Patients With Active Rheumatoid Arthritis (RA)(Protocol No. P08136)Arthritis, RheumatoidDrug: Infliximab;Drug: PlaceboMerck Sharp & Dohme Corp.NULLCompleted18 YearsN/AAll61Phase 2Moldova, Republic of;Romania
702NCT01309854
(ClinicalTrials.gov)
March 201121/2/2011Effects of Administration of Fostamatinib on Blood Concentrations of Pioglitazone in Healthy SubjectsAn Open-Label, Single Center Study to Assess the Pharmacokinetics of Pioglitazone in Healthy Subjects When Administered Alone and in Combination With Fostamatinib 100 mg Twice DailyRheumatoid Arthritis;Healthy Volunteers;Pharmacokinetics;Pioglitazone;Drug-drug Interaction;Amount of Pioglitazone in BloodDrug: fostamatinib;Drug: pioglitazoneAstraZenecaNULLCompleted18 Years55 YearsBoth15Phase 1United States
703NCT01353859
(ClinicalTrials.gov)
March 201113/5/2011A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDsAn Open Label, Local, Multicenter , Phase IIIb Interventional Study to Assess the Efficacy of Tocilizumab (TCZ) in Combination With Methotrexate (MTX) in Indonesian Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDsRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: methotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll39Phase 3Indonesia;Greece
704NCT01332994
(ClinicalTrials.gov)
March 201118/3/2011A Study of RoActemra/Actemra and, if Initially Inadequately Responded to RoActemra/Actemra, Followed by MabThera/Rituxan in Patients With Rheumatoid ArthritisEfficacy and Safety Study of a Sequential Therapy of Tocilizumab (TCZ) and, if Initially Inadequately Responded to Tocilizumab (TCZ), Followed by Rituximab (RTX) in DMARD-IR Patients With Rheumatoid Arthritis (MIRAI)Rheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll519Phase 3Germany
705NCT01317797
(ClinicalTrials.gov)
March 201118/2/2011A Trial to Evaluate the Safety and Tolerability of Namilumab (MT203) in Patients With Mild to Moderate Rheumatoid ArthritisA Phase Ib Double-blind, Placebo-controlled, Randomized, Dose-escalating Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Repeated Subcutaneous Injections of MT203 in Patients With Mild to Moderate Rheumatoid Arthritis on Treatment With MethotrexateRheumatoid ArthritisDrug: namilumab (MT203);Drug: PlaceboTakedaNULLCompleted18 YearsN/AAll24Phase 1Bulgaria;Netherlands
706NCT01294397
(ClinicalTrials.gov)
March 201113/1/2011Effects of Denosumab on the Pharmacokinetics of EtanerceptThe Effects of Denosumab on the Pharmacokinetics of Etanercept in Postmenopausal Women With Low Bone Mineral Density and Rheumatoid ArthritisPostmenopausal;Osteopenia;Rheumatoid Arthritis;OsteoporosisDrug: Etanercept;Drug: DenosumabAmgenNULLTerminated45 Years80 YearsFemale19Phase 1United States
707NCT01313208
(ClinicalTrials.gov)
March 201110/3/2011Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel)A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Etanercept in Subjects With Moderately Active Rheumatoid Arthritis Despite DMARD TherapyRheumatoid ArthritisDrug: etanercept;Drug: Placebo;Drug: DMARD TherapyAmgenNULLCompleted18 Years80 YearsAll210Phase 4United States;Canada
708NCT01276262
(ClinicalTrials.gov)
March 201112/1/2011Effects of Administration of Fostamatinib on Blood Concentrations of an Oral Contraceptive in Healthy Female SubjectsA Single-blind, Placebo-controlled, 2-period, Fixed Sequence Study to Determine the Effects of Coadministration of Fostamatinib 100 mg Twice Daily on the Pharmacokinetics of an Oral Contraceptive in Healthy Female SubjectsScientific Terminology Rheumatoid Arthritis, Healthy Female Volunteers, Pharmacokinetics, Oral Contraceptive, Drug-drug Interaction;Laymen Terminology Level of Oral Contraceptive in Blood, Oral Contraceptive, Rheumatoid Arthritis, Drug -Drug InteractionDrug: fostamatinib;Drug: Microgynon® 30 (Oral contraceptive);Drug: PlaceboAstraZenecaNULLCompleted18 Years45 YearsFemale22Phase 1United Kingdom
709NCT01566201
(ClinicalTrials.gov)
March 201127/3/2012Effects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery DiseaseThe Effect of Inhibition of Interleukin-1 Activity on Vascular and Left Ventricular Function in Patients With Coronary Artery Disease and Coexistent Rheumatoid ArthritisRheumatoid Arthritis;Coronary Artery Disease;InflammationDrug: anakinra;Drug: placeboUniversity of AthensNULLCompleted18 YearsN/ABoth80N/AGreece
710NCT01299961
(ClinicalTrials.gov)
March 201118/2/2011Ultrasound Scores as Indication of Response to Subcutaneous Abatacept in Subjects With Rheumatoid ArthritisMusculoskeletal Ultrasound as a Marker of Therapeutic Response to Abatacept in Rheumatoid ArthritisRheumatoid ArthritisDrug: abataceptUniversity of California, Los AngelesNULLCompleted18 YearsN/AAll25Phase 3United States
711NCT01232569
(ClinicalTrials.gov)
March 20111/11/2010A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid ArthritisA Randomized, Double-blind, Parallel Group Study of Safety and the Effect on Clinical Outcome of Tocilizumab Subcutaneous (sc) Versus Placebo sc in Combination With Traditional Disease Modifying Anti-rheumatic Drugs (DMARDs) in Patients With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Tocilizumab 162 mg;Drug: PlaceboHoffmann-La RocheNULLCompleted18 YearsN/AAll656Phase 3United States;Argentina;Australia;Brazil;Bulgaria;Canada;Colombia;Greece;Guatemala;Hungary;Israel;Malaysia;Mexico;New Zealand;Panama;Philippines;Poland;Russian Federation;South Africa;Spain;Switzerland;Thailand;Peru
712NCT01311622
(ClinicalTrials.gov)
March 201121/2/2011Effects of Administration of Fostamatinib on Blood Concentrations of Warfarin in Healthy SubjectsAn Open-Label, Single Centre Study to Assess the Pharmacokinetics and Pharmacodynamics of Warfarin When Co-Administered With Fostamatinib in Healthy SubjectsRheumatoid Arthritis;Healthy SubjectsDrug: warfarin;Drug: fostamatinibAstraZenecaNULLCompleted18 Years55 YearsBoth15Phase 1United Kingdom
713NCT01339481
(ClinicalTrials.gov)
February 201113/4/2011A Study to Assess the Receptor Occupancy of CD86 and CD80 in Subjects With Rheumatoid Arthritis Initiating AbataceptA Phase 0, Open-Label, Multi-Center, Observational Study to Assess the Receptor Occupancy of CD86 and CD80 in Subjects With Rheumatoid Arthritis Initiating AbataceptRheumatoid ArthritisDrug: abataceptAstellas Pharma IncPerseid Therapeutics LLCCompleted18 YearsN/ABoth26N/AUnited States
714NCT01285752
(ClinicalTrials.gov)
February 201127/1/2011A Study of AK106-001616 in Patients With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: AK106-001616;Drug: Active comparatorAsahi Kasei Pharma CorporationNULLCompleted18 Years65 YearsBoth240Phase 2Czech Republic;Germany;Hungary;Poland;Slovakia;Ukraine;United Kingdom
715NCT01254331
(ClinicalTrials.gov)
February 20113/12/2010An Open-label Study With Tocilizumab in Patients With Rheumatoid Arthritis in a Local EnvironmentOpen Label, Multicenter, Trial to Evaluate Safety, Tolerability and Efficacy of Tocilizumab in Monotherapy or in Combination With MTX in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non Biologic DMARDsRheumatoid ArthritisDrug: tocilizumab [RoActemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll51Phase 3Tunisia
716NCT02092961
(ClinicalTrials.gov)
February 201119/3/2014Randomised Double-Blind, Placebo-Controlled, Parallel Group Study in Patients With Active Rheumatoid Arthritis:Magnetic Resonance Imaging Sub-StudyA Phase IIB, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Fostamatinib Disodium Monotherapy Compared With Placebo or Adalimumab Monotherapy in Patients With Active Rheumatoid Arthritis: Magnetic Resonance Imaging Sub-StudyRheumatoid ArthritisDrug: Fostamatinib;Drug: Adalimumab;Drug: Placebo of Fostamatinib;Drug: Placebo of AdalimumabAstraZenecaNULLTerminated18 YearsN/AAll198Phase 2United States;Bulgaria;Canada;Czech Republic;Germany;Hungary;Netherlands;Poland;Russian Federation;South Africa;United Kingdom
717NCT01282255
(ClinicalTrials.gov)
February 201121/1/2011Efficacy of NNC109-0012 in Subjects With Active Rheumatoid ArthritisA Randomised, Double Blind, Placebo-controlled, Multiple Dose Trial of Anti-IL-20 (109-0012) in Subjects With Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC109-0012;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsAll67Phase 2Czech Republic;Germany;Italy;Poland;Portugal;Romania;Spain;United Kingdom
718NCT01235507
(ClinicalTrials.gov)
February 201115/10/2010A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER)Actemra - Local Bosnian Open, Multicentric, Trial to Evaluate Safety, Tolerability and Efficacy of Tocilizumab in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis After Inadequate Response to DMARDsRheumatoid ArthritisDrug: methotrexate;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll71Phase 3Bosnia and Herzegovina
719NCT01351805
(ClinicalTrials.gov)
January 20114/5/2011Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee PainVitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee PainAutoimmune Diseases;Systemic Inflammatory Process;Knee Pain Chronic;Osteoarthritis;Rheumatoid ArthritisDrug: Fish Oil;Dietary Supplement: Vitamin D;Other: placebo pillBrigham and Women's HospitalNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Active, not recruiting50 YearsN/AAll25876N/AUnited States
720NCT01223911
(ClinicalTrials.gov)
January 201114/10/2010A Multiple Dose Trial of NNC 0151-0000-0000 in Subjects With Rheumatoid ArthritisA Randomised, Double-blind, Placebo-controlled, Multiple Dose Trial of NNC 0151-0000-0000 in Subjects With Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC 0151-0000-0000;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsAll34Phase 2Czech Republic;Denmark;Hungary;Poland;Romania;United Kingdom
721NCT01737944
(ClinicalTrials.gov)
January 201127/11/2012Exposure Study Comparing 3 Routes of Methotrexate (MTX) AdministrationExposure, Safety and Local Tolerance Study Comparing 3 Routes of Methotrexate (MTX) Administration: Vibex-MTX Device, Subcutaneous (SC)and Intramuscular (IM) in Adult Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: Methotrexate (MTX)Antares Pharma Inc.NULLCompleted18 YearsN/AAll38Phase 1/Phase 2United States
722NCT01411215
(ClinicalTrials.gov)
January 201113/5/2011A Study of Rheumatoid Arthritis Treatment With Enbrel in Adult Patient in Outpatient DepartmentA Non-Interventional Study of the Treatment With Etanercept in Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS) Subjects in Rheumatology DepartmentRheumatoid Arthritis;Ankylosing SpondylitisDrug: EnbrelPfizerNULLTerminated18 YearsN/AAll160N/AChina
723NCT02586246
(ClinicalTrials.gov)
January 201123/10/2015Long-term Treatment Study of CDP870 Self-injection in Patients With Active Rheumatoid Arthritis Who Are Participating in the Long-term Treatment Studies (Study 275-08-002 or Study 275-08-004) of CDP870Long-term Treatment Study of CDP870 Self-injection. A Multicenter, Open-label, Long-term Safety Study to Evaluate the Safety and Efficacy of CDP870 Self-injection Administered at a Dose of 200 mg Biweekly for 24 Weeks or Longer in Patients With Active Rheumatoid Arthritis Who Are Participating in the Long-term Treatment Studies (Study 275-08-002 or Study 275-08-004) of CDP870 Administered Concomitantly With or Without Methotrexate (MTX)Active Rheumatoid ArthritisDrug: CDP870Astellas Pharma IncUCB Japan Co. Ltd.CompletedN/AN/ABoth86Phase 3Japan
724NCT01202773
(ClinicalTrials.gov)
January 201114/9/2010A Study in Participants With Rheumatoid ArthritisA Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of LY2127399 in Patients With Moderate to Severe Rheumatoid Arthritis (RA) Who Had an Inadequate Response to One or More TNF-a Inhibitors (FLEX V)Rheumatoid ArthritisDrug: LY2127399;Drug: Placebo Q4W;Drug: Placebo Q2WEli Lilly and CompanyNULLTerminated18 YearsN/AAll456Phase 3United States;Argentina;Australia;Brazil;Colombia;France;Germany;Greece;Italy;Japan;Korea, Republic of;Malaysia;Mexico;New Zealand;Poland;Russian Federation;South Africa;Spain;Taiwan
725NCT01270035
(ClinicalTrials.gov)
January 20114/1/2011Efficacy and Safety of Adalimumab 80 mg Every Other Week With MethotrexateRheumatoid ArthritisDrug: AdalimumabKeio UniversitySaitama Medical UniversityRecruitingN/AN/ABoth40Phase 4Japan
726NCT01207453
(ClinicalTrials.gov)
January 201121/9/2010Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid ArthritisMilnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid ArthritisArthritis, RheumatoidDrug: Milnacipran;Drug: PlaceboBrigham and Women's HospitalForest Laboratories;National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed24 YearsN/AAll49Phase 4United States
727NCT01242514
(ClinicalTrials.gov)
January 201110/11/2010Evaluation of Long-term Safety and Effectiveness of Fostamatinib in the Treatment of Rheumatoid Arthritis (RA)(OSKIRA-X): A Long-term Extension Study to Assess the Safety and Efficacy of Fostamatinib Disodium in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: FostamatinibAstraZenecaNULLTerminated18 YearsN/AAll1917Phase 3United States;Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;Colombia;Czech Republic;Estonia;France;Germany;Hungary;India;Israel;Italy;Latvia;Lithuania;Mexico;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Slovakia;South Africa;Spain;Ukraine;United Kingdom;Netherlands;Turkey
728NCT01264770
(ClinicalTrials.gov)
January 201117/12/2010Evaluation of Efficacy and Safety of Fostamatinib Monotherapy Compared With Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (RA)(OSKIRA-4): A Phase IIB, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Fostamatinib Disodium Monotherapy Compared With Adalimumab Monotherapy in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Fostamatinib and placebo injections;Drug: Adalimumab and placebo of fostamatinib;Drug: Placebo of fostamatinib, fostamatinib, and placebo injectionsAstraZenecaNULLTerminated18 YearsN/AAll644Phase 2United States;Bulgaria;Canada;Czech Republic;Germany;Hungary;Netherlands;Poland;Russian Federation;Slovakia;South Africa;Ukraine;United Kingdom
729NCT01202760
(ClinicalTrials.gov)
January 201114/9/2010A Rheumatoid Arthritis Study in ParticipantsA Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of LY2127399 in Patients With Rheumatoid Arthritis (RA) With or Without Background Disease-Modifying Anti-rheumatic Drug (DMARD) Therapy (FLEX O)Rheumatoid ArthritisDrug: LY2127399;Drug: PlaceboEli Lilly and CompanyNULLCompleted18 YearsN/AAll1004Phase 3United States;Argentina;Australia;Bulgaria;Colombia;Croatia;Hungary;India;Japan;Korea, Republic of;Lithuania;Malaysia;Mexico;New Zealand;Poland;Romania;Russian Federation;Slovakia;South Africa;Sri Lanka;Taiwan;Ukraine;Peru
730NCT01219933
(ClinicalTrials.gov)
January 201111/10/2010A Study of Glucocorticoid Use to Evaluate Systematic Methylprednisolone Reduction in Patients With Rheumatoid Arthritis on Background RoActemra/Actemra (Tocilizumab) (ACT-ALONE)An Open-label, Single-arm Study to Describe Glucocorticoid Use in Rheumatoid Arthritis Patients Treated With Tocilizumab in Daily Clinical Practice and to Evaluate Systematic Glucocorticoid Dose Reduction Once Low Disease Activity is Reached (ACT-ALONE)Rheumatoid ArthritisDrug: methylprednisolone;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll68Phase 4Belgium
731NCT01285310
(ClinicalTrials.gov)
December 9, 201019/11/2010Study of Apremilast to Evaluate the Safety and Effectiveness for Patients With Rheumatoid ArthritisA Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study, To Compare the Efficacy and Safety of Two Doses of Apremilast (CC-10004) in Subjects With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Apremilast 30 mg;Drug: Apremilast 20 mg;Drug: PlaceboAmgenNULLTerminated18 YearsN/AAll237Phase 2United States;Czechia;Poland;Spain;Czech Republic
732NCT01142726
(ClinicalTrials.gov)
December 20103/6/2010Efficacy and Safety Study of Abatacept Subcutaneous Plus Methotrexate in Inducing Remission in Adults With Very Early Rheumatoid ArthritisA Phase 3b, Randomized, Active Controlled Trial to Evaluate the Efficacy and Safety of Abatacept SC in Combination With Methotrexate in Inducing Clinical Remission Compared to Methotrexate Monotherapy in Adults With Very Early RARheumatoid ArthritisDrug: Abatacept;Drug: Methotrexate;Drug: Abatacept placebo;Drug: Methotrexate placeboBristol-Myers SquibbNULLCompleted18 YearsN/AAll511Phase 3United States;Australia;Belgium;Canada;Denmark;Finland;France;Germany;Italy;Korea, Republic of;Mexico;Poland;Russian Federation;South Africa;Sweden;Norway
733NCT01236118
(ClinicalTrials.gov)
December 20104/11/2010A Study of LY2439821 in Rheumatoid ArthritisAn Open-Label Extension Study to Evaluate Safety and Tolerability of Multiple Subcutaneous Doses of LY2439821 in Japanese Patients With Rheumatoid Arthritis on Concomitant MethotrexateRheumatoid ArthritisDrug: LY2439821Eli Lilly and CompanyNULLCompleted20 YearsN/AAll28Phase 1Japan
734NCT01258712
(ClinicalTrials.gov)
December 20108/12/2010Study of Tocilizumab in Combination With Methotrexate for Treatment of Moderate to Severe Rheumatoid Arthritis PatientsRandomized, Placebo-controlled Study of Tocilizumab in Combination With Methotrexate for Treatment of Moderate to Severe Rheumatoid Arthritis PatientsRheumatoid Arthritis (RA)Drug: Tocilizumab + methotrexate(MTX);Drug: Tocilizumab placebo + methotrexate(MTX)Chugai Pharma TaiwanNULLCompleted20 Years75 YearsBoth86Phase 3Taiwan
735NCT01198002
(ClinicalTrials.gov)
December 20108/9/2010A Rheumatoid Arthritis Study in Participants on a Background Treatment of MethotrexateA Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of LY2127399 in Patients With Moderate to Severe Rheumatoid Arthritis (RA) Who Had an Inadequate Response to Methotrexate Therapy (FLEX M)Rheumatoid ArthritisDrug: LY2127399;Drug: Placebo Q2W;Drug: Placebo Q4W;Drug: MethotrexateEli Lilly and CompanyNULLTerminated18 YearsN/AAll1041Phase 3United States;Argentina;Australia;Brazil;Bulgaria;Colombia;Croatia;Hungary;India;Japan;Korea, Republic of;Lithuania;Malaysia;Mexico;New Zealand;Poland;Romania;Russian Federation;Slovakia;South Africa;Sri Lanka;Taiwan;Ukraine;Peru
736NCT01217814
(ClinicalTrials.gov)
November 20107/10/2010Effect of SAR153191 (REGN88) With Methotrexate in Patients With Active Rheumatoid Arthritis Who Failed TNF-a BlockersA Randomized, Double-blind, Parallel-group, Placebo- and Active Calibrator-controlled Study Assessing the Clinical Benefit of SAR153191 Subcutaneous (SC) on Top of MTX in Patients With Active RA Who Have Failed Previous TNF-a AntagonistsRheumatoid ArthritisDrug: Sarilumab;Drug: Placebo;Drug: Golimumab;Drug: methotrexate (MTX);Drug: Folic/folinic acidSanofiRegeneron PharmaceuticalsTerminated18 Years75 YearsAll16Phase 2United States;Colombia;Czechia;Italy;Mexico;Spain;Brazil;Canada;Czech Republic;Germany;Hungary;Norway
737NCT01287858
(ClinicalTrials.gov)
November 201012/1/2011Study to Assess Safety, Tolerability, and Pharmacokinetics of Oral Doses for AC430 in Healthy SubjectsA Phase 1, Randomized, Double Blind, Placebo Controlled, Sequential, Ascending Single-Dose and Multiple-Dose First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AC430 in Healthy SubjectsRheumatoid ArthritisDrug: AC430Daiichi Sankyo Inc.NULLCompleted18 Years45 YearsBoth88Phase 1United States
738NCT01225393
(ClinicalTrials.gov)
November 201018/10/2010A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients With Active Rheumatoid ArthritisA Phase II, Randomized, Double-Blind, Parallel-Group Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patient With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: MLTA3698A;Drug: adalimumab;Drug: leflunomide;Drug: methotrexate;Drug: placeboGenentech, Inc.NULLCompleted18 Years75 YearsBoth211Phase 2Romania;Spain;Bulgaria;Chile;Germany;Hungary;Mexico;Peru;Poland;United States
739NCT01225991
(ClinicalTrials.gov)
November 201020/10/2010Milnacipran for Treatment of Pain in Older Adults With Rheumatoid ArthritisAn Open-label Trial of Milnacipran for the Treatment of Pain in Rheumatoid Arthritis (RA) in Older AdultsRheumatoid ArthritisDrug: MilnacipranUniversity of California, Los AngelesForest LaboratoriesCompleted50 YearsN/AAll18Phase 4United States
740NCT01245790
(ClinicalTrials.gov)
November 201019/11/2010A Study of Fostamatinib in Subjects With Impaired Kidney FunctionAn Open-label, Phase I Study to Assess the Pharmacokinetics of R406 in Subjects With Renal Impairment Compared to Healthy Subjects Following Administration of a Single Dose of Fostamatinib 150 mgRheumatoid Arthritis;Renal ImpairmentDrug: fostamatinibAstraZenecaNULLCompleted18 YearsN/ABoth24Phase 1United States
741NCT01362062
(ClinicalTrials.gov)
October 26, 201026/5/2011Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Participants With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Non-Biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) and/or Anti-tumor Necrosis Factor (Anti-TNF) TherapyA Study to Observe the Safety, Tolerability and Efficacy of Tocilizumab in Patients With Moderate to Severe Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-biologic DMARD and/or Anti TNF Therapy.Rheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll110N/AIndia
742NCT01098201
(ClinicalTrials.gov)
October 201030/3/2010Certolizumab and Lower Extremity Lymph Flow in Rheumatoid Arthritis (RA)The Effect of Certolizumab on Lower Extremity Lymph Flow in Rheumatoid ArthritisRheumatoid ArthritisDrug: CertolizumabUniversity of RochesterNULLCompleted18 YearsN/ABoth5United States
743NCT01149057
(ClinicalTrials.gov)
October 201022/6/2010A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic and/or Biologic DMARDSAn Open-Label Study to Evaluate the Efficacy and Safety Of Tocilizumab in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-biologic DMARDs and/or Biologic DMARDsRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheClalit Health ServicesCompleted18 YearsN/AAll145Phase 4Israel
744NCT01164579
(ClinicalTrials.gov)
October 201015/7/2010Effects of Tofacitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA)An Exploratory Phase 2, Randomized, Double-blind, Multicenter Study To Assess The Effects Of Tofacitinib (Cp-690,550) On Magnetic Resonance Imaging Endpoints, In Methotrexate Naive Subjects With Early Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Tasocitinib plus Methotrexate;Drug: Tofacitinib plus placebo methotrexate;Drug: Placebo tofacitinib plus MethotrexatePfizerNULLCompleted18 YearsN/AAll109Phase 2United States;Argentina;Chile;Croatia;Czech Republic;Hungary;Mexico;Poland;Puerto Rico
745NCT01221636
(ClinicalTrials.gov)
October 201013/10/2010Pharmacokinetic Study to Compare the Blood Levels of Low vs High Metal Manufacture of AbataceptA Study to Compare the Pharmacokinetics of Abatacept (BMS-188667) Drug Product Using Active Pharmaceutical Ingredient Manufactured With a High Concentration of Metals Relative to the Active Pharmaceutical Ingredient Manufactured With a Low Concentration of MetalsRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLWithdrawn18 Years55 YearsBoth0Phase 1United States
746NCT01214733
(ClinicalTrials.gov)
October 20104/10/2010A Study of RoActemra/Actemra (Tocilizumab) Plus DMARDs in Patients With Rheumatoid ArthritisAn Open Label Study of the Safety During Treatment With Tocilizumab (TCZ), in Combination With Disease Modifying Anti-rheumatic Drugs (DMARDs), in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/ABoth30Phase 3South Africa
747NCT01211249
(ClinicalTrials.gov)
October 201028/9/2010GLPG0259 in Methotrexate-refractory Rheumatoid ArthritisRandomized, Double-Blind, Placebo-Controlled, Multicenter, Exploratory Phase II Study to Compare Three Dose Regimens of GLPG0259 vs Placebo, in Combination With Methotrexate, Administered for 12 Weeks to Subjects With Active Rheumatoid Arthritis and an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: GLPG0259 oral capsule;Drug: Placebo;Drug: GLPG0259 (Part B);Drug: Placebo (Part B)Galapagos NVNULLCompleted18 Years70 YearsBoth30Phase 2Belgium;Netherlands;Poland;Russian Federation;Ukraine
748NCT01197144
(ClinicalTrials.gov)
October 20103/9/2010Pain Modulation in Rheumatoid Arthritis (RA) - Influence of AdalimumabPain Modulation in RA - Influence of Adalimumab. A Randomized, Placebo-controlled Study Using Functional Magnetic Resonance Imaging (PARADE)Arthritis, Rheumatoid;Pain;FatigueDrug: adalimumab;Drug: PlaceboKarolinska InstitutetAbbott;Swedish Foundation for Strategic Research;The Swedish Research CouncilCompleted18 YearsN/AAll70N/ASweden
749NCT01217086
(ClinicalTrials.gov)
October 20104/10/2010Program evaLuating the Autoimmune Disease iNvEstigational Drug cT-p13 in RA Patients(PLANETRA)Randomized, Double-blind, Parallel-group, Phase 3 StudyRheumatoid ArthritisDrug: InfliximabCelltrionNULLCompleted18 Years75 YearsBoth617Phase 3Korea, Republic of
750NCT01034306
(ClinicalTrials.gov)
October 201016/12/2009Oral CF101 Tablets Treatment in Patients With Rheumatoid ArthritisA Phase IIB Study of the Efficacy and Safety of Daily CF101 in Patients With Active Rheumatoid Arthritis and Elevated Baseline Expression Levels of Peripheral Blood Mononuclear Cell A3 Adenosine ReceptorsRheumatoid ArthritisDrug: CF101;Drug: Placebo controlCan-Fite BioPharmaNULLCompleted18 Years75 YearsAll79Phase 2Bulgaria;Israel
751NCT01264211
(ClinicalTrials.gov)
October 201028/6/2010Safety and Efficacy of the Combination of Diacerein 100 mg Daily and MTX Versus MTX Alone in the Treatment of Early Rheumatoid Arthritis (RA)A 6-month Pilot Randomised Double-blind Placebo-controlled Multicentre, Phase 2 StudyRheumatoid ArthritisDrug: Diacerein;Drug: PlaceboTRB ChemedicaNULLCompleted18 Years65 YearsBoth40Phase 2Thailand
752NCT01781702
(ClinicalTrials.gov)
October 201030/1/2013Phase 3 Study of Pelubiprofen Tab. & Celebrex Cap. in Rheumatoid Arthritis PatientsA Randomized, Double-blind, Multicenter, Phase 3 Study of Pelubiprofen Tab. & Celebrex Cap. for Comparative Evaluation of Safety & Efficacy in Rheumatoid Arthritis PatientsPelubiprofen;Celebrex;Rheumatoid ArthritisDrug: Pelubiprofen 30 mg;Drug: Celebrex 200 mgDaewon Pharmaceutical Co., Ltd.NULLCompleted18 Years80 YearsBoth120Phase 3NULL
753NCT01185353
(ClinicalTrials.gov)
October 201018/8/2010A Study in Participants With Rheumatoid Arthritis on Background Methotrexate TherapyA Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Parallel-Group, Phase 2b Study of LY3009104 in Patients With Active Rheumatoid Arthritis on Background Methotrexate TherapyArthritis, RheumatoidDrug: LY3009104;Drug: Placebo;Drug: MethotrexateEli Lilly and CompanyIncyte CorporationCompleted18 Years75 YearsAll301Phase 2United States;Croatia;Czechia;Hungary;India;Mexico;Poland;Romania;Ukraine;Argentina;Czech Republic;Peru;United Kingdom
754NCT01208181
(ClinicalTrials.gov)
September 27, 201022/9/2010A Two-Part, 12-Week Study of Etoricoxib as a Treatment for Rheumatoid Arthritis (RA) (MK-0663-107)A Phase III, Two-Part, Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial to Assess the Relative Efficacy and Tolerability of Two Doses of MK-0663/Etoricoxib in Patients With Rheumatoid ArthritisArthritis, RheumatoidDrug: Etoricoxib 60 mg;Drug: Etoricoxib 90 mg;Drug: Placebo to Etoricoxib 60 mg;Drug: Placebo to Etoricoxib 90 mgOrganon and CoNULLCompleted18 YearsN/AAll1404Phase 3Argentina;Austria;Canada;Colombia;Czech Republic;Finland;Germany;Guatemala;India;Lithuania;Mexico;Panama;Peru;Poland;Romania;Russian Federation;Slovakia;South Africa;Taiwan;United Kingdom;United States
755NCT01248780
(ClinicalTrials.gov)
September 201024/11/2010Study of Subcutaneous Golimumab in Chinese Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyA Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Golimumab in the Treatment of Chinese Subjects With Active Rheumatoid Arthritis Despite Methotrexate TherapyRheumatoid ArthritisDrug: Golimumab;Drug: Placebo;Drug: Methotrexate (MTX)Centocor, Inc.Schering-PloughCompleted18 YearsN/AAll264Phase 3China
756NCT01242917
(ClinicalTrials.gov)
September 201015/11/2010A Study to Evaluate the Safety and Efficacy of CCX354-C in Subjects With Rheumatoid Arthritis Partially Responsive to Methotrexate TherapyA Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of CCX354-C in Subjects With Rheumatoid Arthritis Partially Responsive to Methotrexate TherapyRheumatoid ArthritisDrug: CCX-354-C;Drug: Placebo;Drug: CCX354-CChemoCentryxNULLCompleted18 Years75 YearsBoth159Phase 2Belgium;Czech Republic;Germany;Hungary;Netherlands;Poland;Romania;Ukraine
757NCT01197521
(ClinicalTrials.gov)
September 20108/9/2010Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Not Responding.(OSKIRA-1): A Phase III, Multi-centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of Two Dosing Regimens of Fostamatinib Disodium in Rheumatoid Arthritis Patients With an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: fostamatinib;Drug: placebo, fostamatinibAstraZenecaNULLCompleted18 YearsN/AAll923Phase 3United States;Argentina;Australia;Belgium;Brazil;Bulgaria;Chile;Estonia;France;Hungary;India;Mexico;Peru;Poland;Slovakia;Ukraine;United Kingdom;Germany;Russian Federation
758NCT01197534
(ClinicalTrials.gov)
September 20108/9/2010Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Disease Modifying Anti-rheumatic Drug (DMARD) But Not Responding.(OSKIRA-2): A Phase III, Multi-centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of Two Dosing Regimens of Fostamatinib Disodium in Rheumatoid Arthritis Patients With an Inadequate Response to DMARDsRheumatoid ArthritisDrug: fostamatinib;Drug: placebo, fostamatinibAstraZenecaNULLCompleted18 YearsN/AAll913Phase 3United States;Canada;Czech Republic;Germany;India;Israel;Italy;Latvia;Lithuania;Portugal;Romania;Serbia;South Africa;Spain;Ukraine;United Kingdom
759NCT01197755
(ClinicalTrials.gov)
September 20108/9/2010Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate and Have Had Inadequate Response to Single TNF-alpha Antagonist(OSKIRA-3): A Phase III, Multi-centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of Two Dosing Regimens of Fostamatinib Disodium in Rheumatoid Arthritis Patients With Inadequate Response to a TNF-alpha AntagonistRheumatoid ArthritisDrug: fostamatinib;Drug: placeboAstraZenecaNULLCompleted18 YearsN/AAll323Phase 3United States;Argentina;Belgium;Brazil;Canada;Czech Republic;France;Germany;Hungary;Israel;Italy;Mexico;Portugal;South Africa;Spain;United Kingdom;Australia
760NCT01194414
(ClinicalTrials.gov)
September 20101/9/2010A Study to Compare Subcutaneous Versus Intravenous Administration of RoActemra/Actemra (Tocilizumab) in Participants With Moderate to Severe Active Rheumatoid ArthritisA Randomized, Double-blind, Parallel Group Study of the Safety and Effect on Clinical Outcome of Tocilizumab SC Versus Tocilizumab IV, in Combination With Traditional Disease Modifying Anti-rheumatic Drugs (DMARDs), in Patients With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab SC;Drug: tocilizumab IV;Drug: placebo to tocilizumab SC;Drug: placebo to tocilizumab IV;Drug: Disease-modifying antirheumatic drugs (DMARDs)Hoffmann-La RocheNULLCompleted18 YearsN/AAll1262Phase 3United States;Argentina;Australia;Brazil;Bulgaria;Canada;Colombia;France;Germany;Guatemala;Hong Kong;Italy;Lithuania;Mexico;New Zealand;Peru;Philippines;Poland;Puerto Rico;Romania;Russian Federation;Singapore;South Africa;Spain;Thailand;United Kingdom
761NCT01154647
(ClinicalTrials.gov)
September 201028/6/2010Pain Inhibition in Patients With Rheumatoid Arthritis and Central Sensitivity SyndromesUnraveling Impaired Pain Inhibition in Patients With Rheumatoid Arthritis and Central Sensitivity Syndromes: a Series of Experiments Targeting Brain NeurotransmissionFatigue Syndrome, Chronic;Fibromyalgia;Arthritis, RheumatoidDrug: citalopram;Drug: 1 ml 0.9 % NaClVrije Universiteit BrusselResearch Foundation Flanders;Universiteit Antwerpen;University Hospital, Antwerp;Artesis University College, AntwerpNot yet recruiting18 Years65 YearsFemale70N/ABelgium
762NCT01184001
(ClinicalTrials.gov)
September 201017/8/2010A Study To Evaluate The Effect Of Food On How Tasocitinib (CP-690,550) Is Absorbed And Moves Through The Body Following Oral Administration Of Tasocitinib (CP-690,550) Tablets To Healthy SubjectsA Phase 1, Randomized, 2-Period, 2-Sequence, Open Label, Single Dose, Cross-Over Study To Evaluate The Effect Of Food On Pharmacokinetics Of Tasocitinib (CP-690,550) Tablets In Healthy SubjectsRheumatoid ArthritisDrug: Treatment A;Drug: Treatment BPfizerNULLCompleted21 Years55 YearsBoth16Phase 1Singapore
763NCT01116141
(ClinicalTrials.gov)
September 20103/5/2010A Study of CH-4051 in Patients With Rheumatoid Arthritis (RA)A Phase II, Multi-center, Randomized, Parallel Group, Double-blind, MTX Controlled Study to Assess the Clinical Efficacy, Safety and Tolerability of CH-4051 in Patients With Active RA Who Have Shown an Inadequate Response to MTX MonotherapyRheumatoid ArthritisDrug: CH-4051;Drug: Methotrexate (MTX);Drug: Folic AcidChelsea TherapeuticsNULLCompleted18 Years80 YearsBoth250Phase 2NULL
764NCT01208506
(ClinicalTrials.gov)
September 201023/9/2010First-in-Man Trial of NNC114-0005 in Healthy Subjects and Subjects With Rheumatoid ArthritisFirst Human Dose Trial of NNC0114-0000-0005 in Healthy Subjects and Subjects With Rheumatoid ArthritisInflammation;Rheumatoid Arthritis;HealthyDrug: NNC0114-0000-0005;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsAll64Phase 1Germany
765NCT01213017
(ClinicalTrials.gov)
September 201029/9/2010The Effect of Certolizumab Pegol on MRI Synovitis and Bone Edema in Rheumatoid Arthritis PatientsThe Effect of Certolizumab Pegol in Combination With Methotrexate on MRI Synovitis and Bone Edema and Patient Reported Outcomes as Measured Using an Automated Visit Manager System in Moderate to Severe Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: certolizumab pegolOklahoma Medical Research FoundationUCB PharmaCompleted18 YearsN/AAll20Phase 3United States
766NCT01184092
(ClinicalTrials.gov)
August 201016/8/2010A Study To Compare The Amount Of Tasocitinib (CP-690,550) That Is Absorbed Into The Blood Of Healthy Subjects Following Oral Administration Of Three Different Tablet Versions Of Tasocitinib (CP-690,550)Phase 1, Open-Label, Randomized, Single-Dose, 3-Treatment, 3-Period, Cross-Over, Bioequivalence Study Comparing Phase 2b, Phase 3 And Commercial Image Tablet Formulations Of Tasocitinib (CP-690,550) Under Fasted ConditionsRheumatoid ArthritisDrug: Treatment A;Drug: Treatment B;Drug: Treatment CPfizerNULLCompleted21 Years55 YearsBoth24Phase 1Singapore
767NCT01195272
(ClinicalTrials.gov)
August 20102/9/2010A Study of the Effects of RoActemra/Actemra (Tocilizumab) on Neutrophils in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic and/or Non-biologic DMARDs.A 52 Week, Single Center, Open-label Study to Evaluate Neutrophil Function and Survival Effects of Tocilizumab (TCZ) in Patients With Active Rheumatoid Arthritis (RA) on Background Non-biologic DMARDs Who Have an Inadequate Response to Current Non-biologic DMARD and/or Anti-TNF TherapyRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll21Phase 4United Kingdom
768NCT01181050
(ClinicalTrials.gov)
August 201012/8/2010Efficacy of NNC0142-0002 in Subjects With Rheumatoid Arthritis (RA)A Randomised, Single-dose, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy of NNC0142-0002 in Subjects With Active Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC0142-0002;Drug: placeboJanssen Research & Development, LLCNULLCompleted18 Years75 YearsAll63Phase 2Germany;Russian Federation;Ukraine
769NCT01593332
(ClinicalTrials.gov)
July 20107/1/2012Low Dose Rituximab as a First Line Biologic Therapy for the Treatment of DMARD Resistant Patients With Rheumatoid ArthritisDMARD Resistant Rheumatoid ArthritisDrug: RituximabMashhad University of Medical SciencesRoche Pharma AGCompleted19 Years75 YearsBoth44Phase 4Iran, Islamic Republic of
770NCT01147341
(ClinicalTrials.gov)
July 201017/6/2010Can TNF-Alpha Incomplete Secondary Responders Attain a Safe and Efficacious Response Switching to CimziaCan TNF-Alpha Incomplete Secondary Responders Attain a Safe and Efficacious Response By Switching to Certolizumab Pegol (Cimzia)? A Phase IV, Randomized, Multi-Center, Double-Blind, Twelve-Week Study Followed by a 12-Week Open-Label PhaseRheumatoid ArthritisDrug: Cimzia;Drug: PlaceboMichael Schiff, MDUCB PharmaCompleted18 Years75 YearsAll37Phase 4United States
771NCT01146652
(ClinicalTrials.gov)
June 21, 201015/6/2010Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND)A Multi-center, Uncontrolled Extension Study Evaluating Efficacy and Safety of SAR153191 in Patients With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: SAR153191 (REGN88)SanofiRegeneron PharmaceuticalsCompleted18 YearsN/AAll2023Phase 3United States;Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;Chile;Colombia;Czechia;Ecuador;Estonia;Finland;Germany;Greece;Guatemala;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;New Zealand;Peru;Philippines;Poland;Portugal;Romania;Russian Federation;South Africa;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;Czech Republic
772NCT01132118
(ClinicalTrials.gov)
June 201025/5/2010Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid ArthritisHydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid ArthritisRheumatoid Arthritis;Insulin ResistanceDrug: HydroxychloroquineBrigham and Women's HospitalNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed18 YearsN/AAll30Phase 3United States
773NCT01143337
(ClinicalTrials.gov)
June 20109/6/2010Efficacy and Safety Study of MP-435 in Combination With Methotrexate (MTX) in Patients With Rheumatoid ArthritisA Multicenter Randomized, Double-blind, Placebo-controlled Study of MP-435 in Combination With MTX in Patients With Rheumatoid Arthritis - Exploratory StudyRheumatoid ArthritisDrug: MP-435(dose1) + Methotrexate;Drug: Placebo + MethotrexateMitsubishi Tanabe Pharma CorporationNULLCompleted20 Years75 YearsAll112Phase 2Japan
774NCT01101555
(ClinicalTrials.gov)
May 12, 20108/4/2010Repeat Dose Subcutaneous Rhumatoid Arthritis Efficacy StudyA Randomised, Single-blind, Placebo-controlled, Study Toevaluate the Safety, Tolerability, Pharmacodynamics Andpharmacokinetics of Repeat Subcutaneous Administration Ofotelixizumab in Subjects With Rheumatoid ArthritisArthritis, RheumatoidDrug: subcutanious administration;Other: PlaceboGlaxoSmithKlineNULLCompleted18 Years75 YearsAll28Phase 1Russian Federation
775NCT01119859
(ClinicalTrials.gov)
May 20101/4/2010A Study of Tocilizumab (RoActemra/Actemra) Versus Adalimumab in Patients With Rheumatoid ArthritisA Multi-center, Randomized, Blinded, Parallel-group Study of the Reduction of Signs and Symptoms During Monotherapy Treatment With Tocilizumab 8 mg/kg Intravenously Versus Adalimumab 40 mg Subcutaneously in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Tocilizumab;Drug: Adalimumab;Drug: Placebo to tocilizumab;Drug: Placebo to adalimumabHoffmann-La RocheNULLCompleted18 YearsN/AAll326Phase 4United States;Australia;Belgium;Brazil;Czech Republic;Finland;Germany;Greece;Mexico;Portugal;Spain;Sweden;Switzerland;Turkey;United Kingdom;Norway
776NCT01059448
(ClinicalTrials.gov)
May 201028/1/2010Safety and Efficacy of AMG 827 in Subjects With RAA Long-Term Assessment of the Safety and Efficacy of AMG 827 Subcutaneous Treatment in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: AMG 827AmgenNULLTerminatedN/AN/ABoth211Phase 2United States;Bulgaria;Canada;Czech Republic;Latvia;Mexico;Poland;United Kingdom
777NCT01253265
(ClinicalTrials.gov)
May 20101/12/2010A Study in Rheumatoid ArthritisMultiple-Dose, Dose Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LY2439821 in Japanese Patients With Rheumatoid Arthritis on Concomitant Methotrexate TreatmentRheumatoid ArthritisDrug: LY2439821;Drug: PlaceboEli Lilly and CompanyNULLCompleted20 Years75 YearsAll32Phase 1Japan
778NCT01253291
(ClinicalTrials.gov)
May 20101/12/2010A Study of Japanese Rheumatoid Arthritis ParticipantsAn Open-Label Extension Study of Multiple Subcutaneous Doses of LY2127399 in Japanese Patients With Rheumatoid Arthritis Treated With MethotrexateRheumatoid ArthritisDrug: LY2127399Eli Lilly and CompanyNULLCompleted20 Years75 YearsAll26Phase 1Japan
779NCT01245452
(ClinicalTrials.gov)
May 201019/11/2010Study of the Response and Cardiorespiratory Endurance in Early RA Patients Treated With Tocilizumab or MethotrexateComparative Study of the Clinical Response and Cardiorespiratory Endurance in Early Rheumatoid Arthritis Patients Treated With Tocilizumab or Methotrexate Addendum Protocol : Global Gene Expression Profiles in Synovial BiopsiesRheumatoid ArthritisDrug: Tocilizumab;Drug: MethotrexatePatrick DurezNULLCompleted18 Years70 YearsBoth30N/ABelgium
780NCT01090570
(ClinicalTrials.gov)
May 201015/3/2010Safety, Pharmacokinetic (PK), Pharmcodynamic (PD), and Drug-Drug Interaction of PLX3397 in Patients With Rheumatoid Arthritis Who Are Receiving MethotrexateRheumatoid ArthritisDrug: PLX3397PlexxikonNULLWithdrawn18 YearsN/ABoth0Phase 1United States
781NCT01077531
(ClinicalTrials.gov)
April 28, 201025/2/2010Safety, Pharmacodynamics and Pharmacokinetics of GSK2136525 Repeat Dose in Rheumatoid ArthritisA Randomized, Placebo-controlled, Single-blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of Otelixizumab in Rheumatoid Arthritis SubjectsArthritis, RheumatoidDrug: Otelixizumab;Drug: Matching placeboGlaxoSmithKlineNULLTerminated18 Years75 YearsAll12Phase 1Russian Federation;Spain;United Kingdom
782NCT01313858
(ClinicalTrials.gov)
April 201010/3/2011A Study to Investigate the Use of Golimumab (Simponi®) in Participants With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis (P06554)Non-Interventional Study Investigating the Use of Golimumab (Simponi®) in Patients With Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing SpondylitisArthritis, Rheumatoid;Arthritis, Psoriatic;Spondylitis, AnkylosingDrug: Simponi®;Drug: MethotrexateMerck Sharp & Dohme Corp.NULLCompleted18 YearsN/AAll1613N/AGermany
783NCT01117129
(ClinicalTrials.gov)
April 20104/5/2010A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR)Efficacy of MabThera in Patients With Rheumatoid Arthritis, by Measurement of Disease Parameters Through Magnetic Resonance of the Hand (RESONAR Study)Rheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: placebo;Drug: methotrexate;Drug: rituximab [Mabthera/Rituxan]Hoffmann-La RocheNULLTerminated18 Years75 YearsBoth2Phase 4Spain
784NCT01060098
(ClinicalTrials.gov)
April 201029/1/2010T Cells and TNF (Tumor Necrosis Factor): The Impact of TNF BlockadeT Cells and TNF: The Impact of TNF Blockade on Effector T Cell Populations in Rheumatoid Arthritis and Other Conditions Treated With Anti-TNFalpha AgentsRheumatoid Arthritis;Ankylosing Spondylitis;Psoriatic ArthritisDrug: anti-TNF therapy (etanercept or adalimumab)Imperial College LondonNULLCompleted18 Years80 YearsAll48United Kingdom
785NCT01067430
(ClinicalTrials.gov)
April 201010/2/2010Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA)Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis.Rheumatoid ArthritisDrug: Etoricoxib;Drug: DiclofenacNorthumbria Healthcare NHS Foundation TrustNULLWithdrawn18 YearsN/AAll0Phase 4United Kingdom
786NCT01021735
(ClinicalTrials.gov)
April 201027/11/2009Optimal Management of Rheumatoid Arthritis Patients Requiring Biologic TherapyOptimal Management of Rheumatoid Arthritis Patients Requiring Biologic TherapyRheumatoid ArthritisDrug: etanercept or adalimumab;Drug: RituximabUniversity of GlasgowArthritis Research Campaign;NHS Lothian;NHS Grampian;NHS Tayside;NHS Borders;NHS FifeCompleted18 YearsN/ABoth302Phase 4United Kingdom
787NCT01287533
(ClinicalTrials.gov)
April 201030/1/2011Efficacy of Monthly Ibandronate in Women With RA and Reduced Bone Mineral Density Receiving Long-term SteroidsEfficacy of Monthly Ibandronate in Women With Rheumatoid Arthritis and Reduced Bone Mineral Density Receiving Long-term GlucocorticoidsRheumatoid Arthritis;Osteoporosis;OsteopeniaDrug: Ibandronate;Drug: PlaceboYeong-Wook SongNULLCompleted18 Years75 YearsFemale167Phase 4Korea, Republic of
788NCT01034397
(ClinicalTrials.gov)
March 201016/12/2009A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDsA Randomized, Double-blind, Placebo-controlled Study to Assess Efficacy of Tocilizumab+Non-biological DMARD in Reducing Synovitis as Measured by MRI at 12 Weeks After Initiation of Treatment in Patients With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Non-biological DMARDsRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: placebo;Drug: non-biological DMARDsHoffmann-La RocheNULLCompleted18 YearsN/AAll54Phase 4Portugal
789NCT02010216
(ClinicalTrials.gov)
March 20104/12/2013A Study of RoActemra/Actemra (Tocilizumab) in Adult Patients With Rheumatoid Arthritis (SVOBODA Programme)Non-Randomized Phase IV Trial on Efficacy and Safety of Actemra in the Treatment of Adult Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll23Phase 4Kazakhstan
790NCT01197066
(ClinicalTrials.gov)
March 201017/3/2010Open-label, Extension Study of CDP870 in Patients With Rheumatoid ArthritisA Phase ? Multicenter, Open-label, Follow-up Study, to Assess the Safety and Efficacy of Certolizumab Pegol as Additional Medication to Methotrexate, in Patients With Active Rheumatoid Arthritis Who Participated in Study 101-KOA-0801iRheumatoid ArthritisDrug: Certolizumab PegolKorea Otsuka Pharmaceutical Co., Ltd.NULLCompleted18 YearsN/AAll110Phase 3Korea, Republic of
791NCT01256736
(ClinicalTrials.gov)
March 201028/10/2010To Evaluate 1 Year Extension Study of the Efficacy and Safety of Tocilizumab in Patients With Moderate to Severe Rheumatoid ArthritisProspective, Open-labeled, 1 Year Extension Study of the Efficacy and the Safety During Treatment of Tocilizumab in Patients With Active RA Completing Treatment CWP-TCZ301 StudyRheumatoid ArthritisDrug: Tocilizumab;Drug: DMARDsJW PharmaceuticalNULLCompleted18 YearsN/ABoth89Phase 3Korea, Republic of
792NCT01610791
(ClinicalTrials.gov)
March 201031/5/2012A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs (REMISSION)A Single Arm, Open Label Study to Assess the Safety, Tolerability and Efficacy of Tocilizumab in Active Rheumatoid Arthritis Patients With Inadequate Response to the DMARDs (REMISSION Study)Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll121Phase 3Morocco
793NCT01061736
(ClinicalTrials.gov)
March 20102/2/2010Evaluation of Sarilumab (SAR153191/REGN88) on Top of Methotrexate in Rheumatoid Arthritis PatientsA Randomized, Double-blind, Placebo-controlled, Multicenter, Two-part, Dose Ranging and Confirmatory Study With an Operationally Seamless Design, Evaluating Efficacy and Safety of SAR153191 on Top of Methotrexate (MTX) in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to MTX TherapyRheumatoid ArthritisDrug: Sarilumab;Drug: Placebo (for sarilumab);Drug: Methotrexate;Drug: Folic AcidSanofiRegeneron PharmaceuticalsCompleted18 Years75 YearsAll1675Phase 2/Phase 3United States;Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;Chile;Colombia;Czechia;Egypt;Estonia;Finland;Germany;Greece;Hungary;India;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;New Zealand;Norway;Philippines;Poland;Portugal;Romania;Russian Federation;South Africa;Spain;Taiwan;Thailand;Turkey;Ukraine;Czech Republic
794NCT01063062
(ClinicalTrials.gov)
February 28, 20103/2/2010A Study With Tocilizumab [RoActemra/Actemra] Monotherapy or in Combination With Methotrexate in Patients With Rheumatoid Arthritis (PICTURE)A Single-arm, Open-label, Multicenter Study of Tocilizumab Monotherapy or in Combination With Methotrexate to Assess Safety and the Efficacy in Reducing Disease Activity in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDs (PICTURE)Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: MethotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll107Phase 3Egypt
795NCT01038674
(ClinicalTrials.gov)
February 201022/12/2009Safety and Tolerability of Anti-IL-20 in Subjects With Rheumatoid ArthritisA Randomised, Double Blind, Placebo-controlled, Multiple Dose, Dose-escalation, Phase 1 Trial of Anti-IL-20 in Subjects With Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: anti-IL-20;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsAll16Phase 1Belgium;Poland
796NCT01063803
(ClinicalTrials.gov)
February 20102/2/2010Study Evaluating Long-Term Safety Of ATN-103 In Subjects With Rheumatoid ArthritisAn Open-Label Extension Study To Assess The Long-term Safety And Tolerability Of ATN-103 In Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: ATN-103AblynxNULLCompleted18 Years80 YearsBoth266Phase 2United States;Canada;Hungary;Japan;Russian Federation;Serbia;South Africa;Switzerland
797NCT00979771
(ClinicalTrials.gov)
February 201017/9/2009A Study to Investigate the Ability of GSK706769 to Maintain Clinical Remission After Withdrawal of Enbrel in Rheumatoid Arthritis PatientsA Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Investigate the Ability of GSK706769 to Maintain Clinical Remission After Withdrawal of Enbrel in Patients With Rheumatoid ArthritisArthritis, RheumatoidDrug: GSK706769;Drug: PlaceboGlaxoSmithKlineNULLWithdrawn18 YearsN/AAll0Phase 2Netherlands
798NCT00941707
(ClinicalTrials.gov)
February 201016/7/2009An Efficacy and Safety Study of JNJ-38518168 in Adult Participants With Rheumatoid ArthritisA Phase IIa Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy With Synovial Biopsy SubstudyRheumatoid ArthritisDrug: JNJ 38518168;Drug: PlaceboJohnson & Johnson Pharmaceutical Research & Development, L.L.C.NULLTerminated18 Years75 YearsBoth86Phase 2Belgium;Czech Republic;Ireland;Korea, Republic of;Netherlands;Poland;Russian Federation;Spain;Taiwan;United Kingdom;Ukraine
799NCT01052194
(ClinicalTrials.gov)
February 201018/1/2010A 12-week Study of 4 Doses of VX-509 in Subjects With Active Rheumatoid ArthritisA 12-week, Double-blind, Randomized, Parallel-group, Placebo-controlled Study of 4 Doses of VX-509 in Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Placebo;Drug: VX-509Vertex Pharmaceuticals IncorporatedNULLCompleted18 Years75 YearsBoth206Phase 2United States;Belgium;Croatia;Germany;Hungary;Poland;Puerto Rico;Romania;Russian Federation;Serbia
800NCT01059864
(ClinicalTrials.gov)
February 201028/1/2010Study Of The Effects Of Atorvastatin On Cholesterol Levels In Rheumatoid Arthritis Patients Taking CP-690,550Phase 2 Study Of The Effects Of Open-Label CP-690,550 And Double-Blind Atorvastatin On Lipids In Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CP-690,550;Drug: Atorvastatin;Drug: Atorvastatin PlaceboPfizerNULLCompleted18 YearsN/AAll111Phase 2United States;Korea, Republic of
801NCT01754805
(ClinicalTrials.gov)
January 22, 201019/12/2012A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid ArthritisA Phase 1b, Open-Label, Single Sequence, Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: peficitinib;Drug: methotrexateAstellas Pharma IncNULLCompleted18 Years65 YearsAll15Phase 1United States
802NCT01039688
(ClinicalTrials.gov)
January 201023/12/2009Comparing The Effectiveness And Safety Of 2 Doses Of An Experimental Drug, CP-690,550, To Methotrexate (MTX) In Patients With Rheumatoid Arthritis Who Have Not Previously Received MTXPhase 3 Randomized, Double-blind Study Of The Efficacy And Safety Of 2 Doses Of Cp-690,550 Compared To Methotrexate In Methotrexate Navie Patients With Rheumatoid ArthritisArthritis, RheumatoidDrug: CP-690,550;Drug: Disease-modifying antirheumatic drugPfizerNULLCompleted18 Years99 YearsAll956Phase 3United States;Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;Colombia;Costa Rica;Czechia;Dominican Republic;Germany;Hungary;India;Korea, Republic of;Malaysia;Mexico;New Zealand;Peru;Philippines;Poland;Puerto Rico;Russian Federation;Slovakia;Spain;Sweden;Taiwan;Thailand;Ukraine;Czech Republic
803NCT01071798
(ClinicalTrials.gov)
January 201018/2/2010An Observational Study on the Safety and Effectiveness of Rituximab in Patients With Severe Active Rheumatoid ArthritisA Prospective, Multi-center, Non-interventional Observational Study to Evaluate the Safety and Effectiveness of MabThera® (Rituximab) Within the First 6 Months (in Case of Re-therapy the First 12 Months) of Treatment in Patients With Severe Active Rheumatoid Arthritis in Routine CareRheumatoid ArthritisDrug: RituximabHoffmann-La RocheNULLCompleted18 YearsN/AAll1653N/AGermany;United States
804NCT02731560
(ClinicalTrials.gov)
January 20106/3/2016Rituximab (RTX) for Disease Modifying Anti Rheumatic Drug (DMARD) Non-responders in Pakistan: The Pakistan Rituximab Study (PARIS)Efficacy and Safety of Rituximab in Pakistani Patients With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: RituximabProf. Abid Z. FarooqiAga Khan University;Fatima Memorial Hospital;Fauji Foundation Hospital, RawalpindiCompleted18 Years80 YearsBoth74Phase 4NULL
805NCT01034137
(ClinicalTrials.gov)
January 201016/12/2009A Study of Tocilizumab and Methotrexate in Combination or as Monotherapy in Treatment-Naïve Patients With Early Rheumatoid ArthritisU-ACT-EARLY: A Multi-center, Randomized, Double Blind, Placebo Controlled Study to Evaluate Remission in DMARD and Biological naïve Early Rheumatoid Arthritis (RA) Subjects Treated With Tocilizumab (TCZ) Plus Tight Control Methotrexate (MTX) , TCZ Monotherapy or Tight Control MTX MonotherapyRheumatoid ArthritisDrug: methotrexate;Drug: placebo MTX;Drug: placebo TCZ;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll317Phase 3Netherlands
806NCT02368093
(ClinicalTrials.gov)
January 20104/2/2015Efficacy Study of Dextromethorphan to Treat Rheumatoid ArthritisA Double-blind, Placebo-controlled, Therapeutic Trial With Antitussive Drug-Dextromethorphan: Aimed to Determine Its Therapeutic Effect in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Dextromethorphan hydrobromideTaichung Veterans General HospitalTSH Biopharm Corporation LimitedCompleted18 YearsN/AAll48N/ANULL
807NCT00752154
(ClinicalTrials.gov)
January 201011/9/2008Curcumin in Rheumatoid ArthritisCurcumin in Rheumatoid Arthritis - ACross-Over Pilot StudyRheumatoid ArthritisDrug: Curcumin (Longvida™)University of California, Los AngelesNULLRecruiting18 YearsN/ABoth40Phase 0United States
808NCT01089023
(ClinicalTrials.gov)
January 20108/3/2010A Study of Tocilizumab as Monotherapy or in Combination With DMARDs in Patients With Moderate to Severe Active Rheumatoid ArthritisMulticenter, Open-Label Study to Evaluate the Safety, Tolerability and the Effect on Disease Activity of Tocilizumab in Patients With Active Rheumatoid Arthritis on Background Non-biologic DMARDs Who Have an Inadequate Response to Current Non-biologic DMARD and/or Anti- TNF Therapy.Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll95Phase 4Bahrain;Iran, Islamic Republic of;Kuwait;Qatar;United Arab Emirates
809NCT01198509
(ClinicalTrials.gov)
January 20108/9/2010Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)Rheumatoid Arthritis;Psoriatic Arthritis;Periodontal DiseaseDrug: doxycycline;Drug: vancomycinNew York University School of MedicineNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS);Memorial Sloan Kettering Cancer CenterCompleted18 Years70 YearsAll178N/AUnited States
810NCT01000441
(ClinicalTrials.gov)
December 23, 200922/10/2009Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid ArthritisRotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid ArthritisRheumatoid ArthritisDrug: infliximab, etanercept, adalimumab;Drug: abatacept, rituximab or tocilizumabUniversity Hospital, Strasbourg, FranceNULLCompleted18 YearsN/AAll300Phase 4France;Monaco
811NCT00950989
(ClinicalTrials.gov)
December 200930/7/2009AMG 827 in Rheumatoid Arthritis Subjects With Inadequate Response to MethotrexateA Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects With Rheumatoid Arthritis and an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: AMG 827 70 mg;Drug: AMG 827 140 mg;Drug: AMG 827 210 mg;Drug: Placebo;Drug: Stable weekly dose of methotrexateAmgenNULLCompleted18 Years70 YearsBoth240Phase 2Bulgaria;Canada;Czech Republic;Hungary;Latvia;Mexico;Poland;United Kingdom;United States
812NCT01001832
(ClinicalTrials.gov)
December 200926/10/2009Efficacy, Pharmacokinetics, Safety, and Immunogenicity Study of Abatacept Administered Subcutaneously to Treat Rheumatoid Arthritis in Japanese PatientsA Phase II/III, Multicenter, Randomized, Double-Blind, Double-Dummy Study to Assess Similarity of the Efficacy, Pharmacokinetics, Safety and Immunogenicity of Abatacept Administered Subcutaneously or Intravenously in Japanese Subjects With Rheumatoid Arthritis, Receiving Background Methotrexate, and Experiencing an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Intravenous (IV) abatacept;Drug: Subcutaneous (SC) abataceptBristol-Myers SquibbNULLCompleted20 YearsN/AAll118Phase 2/Phase 3Japan
813NCT01029613
(ClinicalTrials.gov)
December 20099/12/2009Adalimumab in Rheumatoid Arthritis. An Investigation of Wholebody MRI, Conventional MRI, CT and Circulating BiomarkersAdalimumab in Rheumatoid Arthritis. An Investigation of Changes in Disease Activity and Course of Joint Destruction by Use of 3 Tesla Whole-Body MRI, Dedicated 3 Tesla MRI and CT of the Hand, and Soluble BiomarkersRheumatoid ArthritisDrug: AdalimumabGlostrup University Hospital, CopenhagenNULLCompleted18 Years85 YearsBoth40N/ADenmark
814NCT01004432
(ClinicalTrials.gov)
December 200929/10/2009Golimumab in Rheumatoid Arthritis Participants With an Inadequate Response to Etanercept (ENBREL) or Adalimumab (HUMIRA)A Golimumab Phase 3b, Multicenter, Switch Assessment of Subcutaneous and Intravenous Efficacy in Rheumatoid Arthritis Patients Who Have Inadequate Disease Control Despite Treatment With Etanercept (ENBREL) or Adalimumab (HUMIRA)Arthritis;Arthritis, Rheumatoid;Autoimmune DiseasesDrug: Golimumab 50 mg SC;Drug: Golimumab 2 mg/kg IV;Drug: Methotrexate (MTX);Drug: Placebo SC;Drug: Placebo IVJanssen Biotech, Inc.Merck Sharp & Dohme Corp.Completed18 YearsN/AAll433Phase 3United States;Austria;Belgium;Canada;Germany;Greece;Sweden;United Kingdom;France;Spain
815NCT01023256
(ClinicalTrials.gov)
December 200919/11/2009Safety and Preliminary Efficacy of MOR103 in Patients With Active Rheumatoid ArthritisA Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Preliminary Clinical Activity and Immunogenicity of Multiple Doses of MOR103 Administered Intravenously to Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: MOR103MorphoSys AGNULLCompleted18 YearsN/AAll96Phase 1/Phase 2Bulgaria;Germany;Netherlands;Poland;Ukraine
816NCT01008852
(ClinicalTrials.gov)
December 20095/11/2009Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid ArthritisRandomized, Parallel, Double-Blind, Placebo-Controlled Trial To Evaluate The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis On A Stable Background Of MethotrexateActive Rheumatoid ArthritisDrug: SBI-087;Drug: PlaceboPfizerEmergent Product Development Seattle LLCCompleted18 YearsN/ABoth210Phase 2United States;Argentina;Canada;Chile;Hungary;Japan;Mexico;Poland;Serbia;Spain;Greece;Turkey
817NCT01027728
(ClinicalTrials.gov)
December 20097/12/2009Study to Evaluate Safety and Efficacy of CCX 354-C in Subjects With Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled, Phase I/II Study to Evaluate the Safety and Efficacy of CCX354-C in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: CCX 354-CChemoCentryxNULLCompleted18 Years75 YearsBoth24Phase 1/Phase 2Belgium;Romania
818NCT01044498
(ClinicalTrials.gov)
December 20097/1/2010A Study of Tocilizumab in Combination With an Oral Contraceptive in Patients With Rheumatoid ArthritisAn Open-label, Multi-center, One Sequence Cross-over Drug Interaction Study to Investigate the Effect of Tocilizumab (TCZ, RO4877533) on the Pharmacokinetics and Pharmacodynamics of an Oral Contraceptive (OC) in Female Patients With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Tocilizumab;Drug: Ortho-Novum® 1/35Hoffmann-La RocheNULLCompleted18 Years44 YearsFemale46Phase 3United States
819NCT00976599
(ClinicalTrials.gov)
November 200911/9/2009A Study To Evaluate The Mechanism Of Action Of CP-690,550 In Patients With Rheumatoid ArthritisAn Exploratory Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Assess The Pharmacodynamics Of CP-690,550, Administered Orally Twice Daily (BID) For 4 Weeks, In Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CP-690,550 + methotrexate;Drug: Placebo + MethotrexatePfizerNULLCompleted18 YearsN/AAll29Phase 2United States
820NCT01009879
(ClinicalTrials.gov)
November 20095/11/2009Human Tumor Necrosis Factor Alpha (TNFa)-Induced Pre-B Cell Bone Marrow EmigrantsHuman TNFa-Induced Pre-B Cell Bone Marrow EmigrantsRheumatoid ArthritisDrug: EtanerceptUniversity of PittsburghAmgenWithdrawn18 YearsN/ABoth0Phase 4United States
821NCT01010581
(ClinicalTrials.gov)
November 20099/11/2009SC12267 (4SC-101) in Combination With Methotrexate in Patients With Rheumatoid ArthritisA Randomized, Double Blind, Placebo-Controlled, Phase II Study to Evaluate Efficacy, Safety, and Pharmacokinetics of SC12267 (35 mg) in Combination With Methotrexate Compared to Methotrexate Alone in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: SC12267 (4SC-101);Drug: Placebo;Drug: Methotrexate;Drug: Folic Acid4SC AGNULLCompleted18 YearsN/ABoth266Phase 2Bulgaria;Czech Republic;Poland;Romania
822NCT00844714
(ClinicalTrials.gov)
November 200912/2/2009Cardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab TherapyCardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab TherapyEndothelial Function;Rheumatoid Arthritis;InflammationDrug: RituxanUniversity of California, San FranciscoGenentech, Inc.Completed18 YearsN/AAll20N/AUnited States
823NCT00996203
(ClinicalTrials.gov)
October 31, 200915/10/2009A Study of Tocilizumab Added to DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to DMARDs.Local Open-label Multicenter Study to Evaluate the Quality of Life in Patients With Moderate to Severe Active Rheumatoid Arthritis and an Inadequate Response to DMARDs When Adding Tocilizumab (TCZ)Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: DMARDs (disease-modifying antirheumatic drugs)Hoffmann-La RocheNULLCompleted18 YearsN/AAll201Phase 4Russian Federation
824NCT00951275
(ClinicalTrials.gov)
October 31, 200930/7/2009A Study of Tocilizumab + DMARDs in Patients With Moderate to Severe Active Rheumatoid ArthritisA Single Arm, Open-label Study of Early Improvement of Anemia and Fatigue During Treatment With Tocilizumab (TCZ) in Combination With DMARDs, in Adult Patients With Moderate to Severe Active Rheumatoid Arthritis.Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: Standard DMARDs (Disease Modifying Anti Rheumatic Drugs)Hoffmann-La RocheNULLCompleted18 YearsN/AAll105Phase 3Italy
825NCT01007435
(ClinicalTrials.gov)
October 31, 20093/11/2009A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid ArthritisA Multi-center, Randomized, Double-blind, Parallel Group Study of the Safety, Disease Remission and Prevention of Structural Joint Damage During Treatment With Tocilizumab (TCZ), as a Monotherapy and in Combination With Methotrexate (MTX), Versus Methotrexate in Patients With Early, Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: Tocilizumab;Drug: Placebo to tocilizumab;Drug: Methotrexate;Drug: Placebo to methotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll1162Phase 3United States;Argentina;Australia;Austria;Brazil;Canada;China;Colombia;Denmark;Finland;France;Germany;Greece;Guatemala;Hong Kong;Hungary;Ireland;Israel;Italy;Macedonia, The Former Yugoslav Republic of;Mexico;New Zealand;Panama;Peru;Philippines;Poland;Portugal;Puerto Rico;Russian Federation;Singapore;South Africa;Spain;Sweden;Thailand;Turkey;United Kingdom;Czech Republic
826NCT01211834
(ClinicalTrials.gov)
October 200929/9/2010Efficacy and Safety of Tocilizumab in Combination With DMARDs in Patients With Moderate to Severe Rheumatoid ArthritisA Randomized, Double-blind, Placebo-controlled, Parallel Group Study of the Efficacy and the Safety During Treatment With Tocilizumab vs Placebo in Combination With Traditional DMARD Therapy in Patients With Moderate to Severe Active RA and an Inadequate Response to Current DMARD TherapyRheumatoid ArthritisDrug: tocilizumab;Drug: DMARDs;Drug: PlaceboJW PharmaceuticalNULLCompleted18 YearsN/ABoth90Phase 3Korea, Republic of
827NCT00960440
(ClinicalTrials.gov)
October 200914/8/2009Study of CP-690,550 Versus Placebo In Rheumatoid Arthritis Patients On Background Methotrexate With Inadequate Response To Tumor Necrosis Factor (TNF) InhibitorsPhase 3, Randomized, Double-Blind, Placebo-Controlled Study Of The Safety And Efficacy Of 2 Doses Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate With Inadequate Response To TNF InhibitorsArthritis, RheumatoidDrug: CP-690,550;Drug: PlaceboPfizerNULLCompleted18 YearsN/AAll399Phase 3United States;Australia;Austria;Belgium;Brazil;Canada;France;Germany;Ireland;Italy;Korea, Republic of;Puerto Rico;Spain;Taiwan;United Kingdom
828NCT00996606
(ClinicalTrials.gov)
October 200915/10/2009A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDsOpen Label, Multicentric Phase IIIb Study to Evaluate the Effect of Tocilizumab in Combination With DMARDs in the Inhibition of Progression of Synovitis, Bone Marrow Edema, and Erosions Evaluated by Dedicated Magnetic Resonance Imaging (MRI) in the Hand of Patients With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: DMARDs;Drug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll58Phase 3Italy
829NCT01120366
(ClinicalTrials.gov)
October 20096/5/2010Success of Tocilizumab in RA Patients With Remission Induction and Sustained Efficacy After DiscontinuationSuccess of Tocilizumab in RA Patients With Remission Induction and Sustained Efficacy After DiscontinuationRheumatoid ArthritisDrug: Tocilizumab plus methotrexate;Drug: TocilizumabSURPRISE Study GroupNULLCompleted20 Years75 YearsBoth233Phase 4Japan
830NCT00929864
(ClinicalTrials.gov)
October 200929/6/2009Abatacept Versus Adalimumab Head-to-HeadA Randomized, Head-to-Head, Single-Blind Study to Compare the Efficacy and Safety of Subcutaneous Abatacept Versus Subcutaneous Adalimumab, Both With Background Methotrexate, in Biologic-Naive Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: Abatacept;Drug: AdalimumabBristol-Myers SquibbNULLCompleted18 YearsN/AAll869Phase 3United States;Argentina;Canada;Chile;Peru
831NCT00938587
(ClinicalTrials.gov)
October 200913/7/2009A Study Of PF-04171327 In The Treatment Of The Signs And Symptoms Of Rheumatoid ArthritisA Phase 2a, Randomized, Double-Blind, Active And Placebo-Controlled Study Of PF-04171327 In The Treatment Of The Signs And Symptoms Of Rheumatoid ArthritisRheumatoid ArthritisDrug: PF-04171327 10 mg;Other: Prednisone Placebo;Drug: PF-04171327 25 mg;Drug: Prednisone 5 mg;Other: Placebo for PF-04171327;Other: PlaceboPfizerNULLCompleted18 YearsN/AAll86Phase 2United States;Czechia;Hong Kong;Hungary;Korea, Republic of;Russian Federation;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;Czech Republic
832NCT01123655
(ClinicalTrials.gov)
October 200912/5/2010Phase 1 Trial of Type II Collagen (CII) APL A12 in Rheumatoid Arthritis PatientsPhase 1 Trial of CII APL A12 in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: APLA12;Drug: PlaceboVA Office of Research and DevelopmentNULLCompleted18 Years85 YearsAll22Phase 1United States
833NCT00993317
(ClinicalTrials.gov)
October 20099/10/2009A Study of CDP870 as Add-on Meditation to Methotrexate (MTX) in Patients With Rheumatoid ArthritisA Phase III Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, 24-week Study to Assess the Efficacy and Safety of Certolizumab Pegol as Additional Medication to MTX in Patients With Active Rheumatoid Arthritis Who Have an Incomplete Response to MethotrexateRheumatoid ArthritisDrug: Placebo of CDP870;Drug: CDP870 200mg;Drug: MethotrexateKorea Otsuka Pharmaceutical Co., Ltd.NULLCompleted18 Years75 YearsAll127Phase 3Korea, Republic of
834NCT00984815
(ClinicalTrials.gov)
September 200923/9/2009Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug TreatmentOpen-Label Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-Steroidal Anti-Inflammatory Drug TreatmentOsteoarthritis;Rheumatoid Arthritis;Chronic Low Back Pain;Chronic Regional Pain Syndrome;Chronic Soft Tissue PainDrug: HZT-501Horizon Pharma Ireland, Ltd., Dublin IrelandNULLCompleted40 Years80 YearsAll86Phase 3United States
835NCT00913458
(ClinicalTrials.gov)
September 200926/5/2009Study Evaluating Etanercept Plus Methotrexate in Early Rheumatoid ArthritisA 3-Phase Study to Evaluate Sustained Remission and Productivity Outcomes in Subjects With Early Rheumatoid Arthritis Initiated on Treatment With Etanercept Plus MethotrexateActive Rheumatoid Arthritis;Arthritis, Rheumatoid;Rheumatoid ArthritisDrug: etanerceptPfizerNULLCompleted18 YearsN/AAll306Phase 4France;Germany;Ireland;Italy;Monaco;Netherlands;Poland;Qatar;Romania;Russian Federation;Spain;Switzerland;United Kingdom
836NCT01075477
(ClinicalTrials.gov)
September 200924/2/2010An Observational Study on Patients With Rheumatoid Arthritis Treated With MabThera (Rituximab)Naturalistic Prospective Non-interventional Study on Rheumatoid Arthritis (RA) Patients Treated With Rituximab According to Local Treatment GuidelinesRheumatoid ArthritisDrug: rituximab [Mabthera/Rituxan]Hoffmann-La RocheNULLCompleted18 YearsN/ABoth151N/AFinland;United States
837NCT00959036
(ClinicalTrials.gov)
September 200913/8/2009Study Evaluating Multiple Doses Of ATN-103 In Subjects With Active Rheumatoid ArthritisA Seamless, Phase 1/2, Multiple Ascending Dose, Proof Of Concept Study Of ATN-103 Administered To Subjects With Active Rheumatoid Arthritis On A Background Of MethotrexateActive Rheumatoid ArthritisDrug: ATN-103;Drug: Placebo;Drug: MethotrexateAblynxNULLCompleted18 Years80 YearsBoth252Phase 1/Phase 2United States;Belgium;Canada;Germany;Hungary;Russian Federation;Serbia;South Africa;Switzerland
838NCT01253226
(ClinicalTrials.gov)
September 20091/12/2010A Study for Japanese Participants With Rheumatoid Arthritis (RA)Multiple-Dose, Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LY2127399 in Japanese Patients With Rheumatoid Arthritis Treated With MethotrexateRheumatoid ArthritisDrug: LY2127399 (Tabalumab);Drug: PlaceboEli Lilly and CompanyNULLCompleted20 Years75 YearsAll32Phase 1Japan
839NCT00973479
(ClinicalTrials.gov)
September 20094/9/2009An Effectiveness and Safety Study of Intravenous Golimumab in Patients With Active Rheumatoid Arthritis Despite Treatment With Methotrexate TherapyA Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Golimumab, an Anti-TNFalpha Monoclonal Antibody, Administered Intravenously, in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyArthritis, RheumatoidDrug: Golimumab;Other: Placebo;Drug: methotrexate (MTX)Centocor, Inc.Schering-PloughCompleted18 YearsN/AAll592Phase 3United States;Argentina;Australia;Colombia;Hungary;Korea, Republic of;Lithuania;Malaysia;Mexico;New Zealand;Poland;Russian Federation;Ukraine
840NCT01224041
(ClinicalTrials.gov)
August 200918/10/2010Study to Evaluate the Efficacy of Tacrolimus in Rheumatoid Arthritis Patients Shown Unsuccessful Response to MethotrexateClinical Study to Evaluate the Efficacy of Tacrolimus in Active Rheumatoid Arthritis Patients Shown Unsuccessful Response Against Methotrexate: Non-comparative, Single Arm, Multi-center, Phase 4 StudyRheumatoid ArthritisDrug: TacrolimusAstellas Pharma IncAstellas Pharma Korea, Inc.Completed18 Years75 YearsBoth78Phase 4Korea, Republic of
841NCT00965653
(ClinicalTrials.gov)
August 200918/8/2009A Study of Subcutaneously Administered Tocilizumab in Patients With Rheumatoid ArthritisOpen-label, Multicenter, Randomized, Parallel Study to Investigate pk, pd, Efficacy and Safety of Tocilizumab (TCZ, RO4877533) Following Subcutaneous Administration of TCZ 162 mg Weekly or Every Other Week in Combination With Methotrexate in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: folic acid;Drug: methotrexate;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 Years75 YearsBoth29Phase 1Canada;New Zealand;Spain;United Kingdom
842NCT01870128
(ClinicalTrials.gov)
August 200930/5/2013Comparison of Three Different Treatment Regimes in Early Rheumatoid Arthritis: A Randomized Open-labelled TrialComparison of Three Different Treatment Regimes in Early Rheumatoid Arthritis: A Randomized Open-labelled TrialRheumatoid ArthritisDrug: Combination Steroid;Drug: Methotrexate;Drug: CombinationAll India Institute of Medical Sciences, New DelhiNULLCompleted18 Years60 YearsBoth60Phase 3India
843NCT00929357
(ClinicalTrials.gov)
August 200925/6/2009Retrospective Evaluation of the Radiographic Efficacy of Conventional and Biologic TreatmentA Retrospective Evaluation of the Radiographic Efficacy of Different Conventional Systemic Therapies and Biologics in Patients With Rheumatoid Arthritis in Routine Practice.Rheumatoid ArthritisDrug: DMARDs or BiologicsPfizerNULLCompleted18 YearsN/AAll156N/ADenmark
844NCT00965757
(ClinicalTrials.gov)
July 31, 200925/8/2009A Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Combination Therapy of T-614 and Methotrexate in Rheumatoid Arthritis Patients With an Inadequate Response to MethotrexateA Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Combination Therapy of T-614 and Methotrexate in Rheumatoid Arthritis Patients With an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: T-614;Drug: PlaceboEisai Co., Ltd.FUJIFILM Toyama Chemical Co., Ltd.Completed20 Years69 YearsAll253Phase 3Japan
845NCT00928512
(ClinicalTrials.gov)
July 200925/6/2009Efficacy, Safety and Tolerability of AIN457 in Patients With Rheumatoid Arthritis (RA) Taking Methotrexate (MTX)A 16-week Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Dose-finding Study to Evaluate the Efficacy, Safety and Tolerability of Subcutaneous Secukinumab (AIN457) Followed by an Extension Phase up to a Total of 60 Weeks in Patients With Active Rheumatoid Arthritis Despite Stable Treatment With MethotrexateRheumatoid ArthritisDrug: Secukinmab;Drug: PlaceboNovartis PharmaceuticalsNULLCompleted18 YearsN/AAll237Phase 2United States;Belgium;Czech Republic;Germany;Hungary;Japan;Korea, Republic of;Poland;Russian Federation;Slovakia;Taiwan;Puerto Rico
846NCT00903383
(ClinicalTrials.gov)
July 200914/5/2009Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable MethotrexateA Phase 2, Multi-center, Randomized, Double Blind, Placebo-controlled, Multiple-dose Study to Determine the Safety and Efficacy of Daily Orally Administered LX3305 in Subjects With Active Rheumatoid Arthritis (RA) on Stable Methotrexate (MTX) TherapyRheumatoid ArthritisDrug: LX3305 low dose;Drug: LX3305 mid dose;Drug: LX3305 high dose;Drug: PlaceboLexicon PharmaceuticalsNULLCompleted18 Years75 YearsAll208Phase 2United States;Bulgaria;Czech Republic;Hungary;Poland;Serbia
847NCT00927927
(ClinicalTrials.gov)
June 200924/6/2009First-in-man Trial of NNC0142-0002 in Patients With Rheumatoid ArthritisA Randomized, Double-blind, Placebo-controlled, Dose-escalation, Single and Multiple Dose Trial to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0142-0002 Administered Subcutaneously to Subjects With Rheumatoid ArthritisInflammation;Rheumatoid ArthritisDrug: NNC0142-0002;Drug: placeboJanssen Research & Development, LLCNULLCompleted18 Years75 YearsAll65Phase 1Germany
848NCT01010503
(ClinicalTrials.gov)
June 20099/11/2009A Study of Tocilizumab With or Without Methotrexate in Patients With Rheumatoid Arthritis.Evaluation of Adherence and Persistence to Tocilizumab in Combination With Methotrexate or Tocilizumab Monotherapy in Patients With Moderate to Severe Active Rheumatoid Arthritis in Local Environment.Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll32Phase 4Slovakia
849NCT00977106
(ClinicalTrials.gov)
June 200918/8/2009TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNFComparative Double Blind Placebo Controlled Clinical Study on Tocilizumab Rapid Efficacy on Patients Relief in rheumatoïd Arthritis With an Inadequate Response to DMARDs or Anti TNF :TORPEDORheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: placeboHoffmann-La RocheNULLCompleted18 YearsN/AAll103Phase 3France
850NCT00838565
(ClinicalTrials.gov)
May 20, 20094/2/2009Phase I Study Of The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Multiple Intravenously Administered Doses Of PF-04236921 In Patients With Rheumatoid ArthritisPhase 1, Randomized, Patient And Investigator-blind, Placebo-controlled Study To Investigate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Multiple Intravenously Administered Doses Of Pf-04236921 In Patients With Rheumatoid Arthritis Receiving MethotrexateRheumatoid ArthritisDrug: Placebo;Drug: dose level 1;Drug: dose level 2;Drug: dose level 3;Drug: dose level 4PfizerNULLCompleted18 Years70 YearsAll41Phase 1United States;Korea, Republic of;Spain
851NCT00887341
(ClinicalTrials.gov)
May 200922/4/2009A Study Comparing Infusion Rates of Tocilizumab in Patients With Moderate to Severe Rheumatoid ArthritisPhase II Multi-centre, Randomized, Parallel Group, Pilot Trial to Compare the Incidence of Tocilizumab Related Infusion Reactions in Moderate to Severe RA Patients When Infusion is Made Over 1 Hour Against 31 MinutesRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll76Phase 2Spain
852NCT00902486
(ClinicalTrials.gov)
May 200913/5/2009INCB028050 Compared to Background Therapy in Patients With Active Rheumatoid Arthritis (RA) With Inadequate Response to Disease Modifying Anti-Rheumatic DrugsA Randomized, Double-blind, Placebo Controlled, Dose Ranging, Parallel Group, Phase 2 Study of INCB028050 Compared to Background Therapy in Patients With Active RA With Inadequate Response to Any Disease Modifying Anti-Rheumatic Drugs (DMARD) Therapy Including BiologicsRheumatoid ArthritisDrug: INCB028050;Drug: PlaceboIncyte CorporationNULLCompleted18 YearsN/AAll127Phase 2United States;Czechia;Czech Republic
853NCT00920608
(ClinicalTrials.gov)
May 200912/6/2009A Study to Assess the Pharmacokinetics of Methotrexate Given With and Without AZD9056 in Rheumatoid Arthritis PatientsA Phase I, Multi-centre, Open-label, Fixed-sequence Study to Assess the Pharmacokinetics of Methotrexate Alone and When Co-administered With AZD9056 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: AZD9056;Drug: MethotrexateAstraZenecaNULLWithdrawn18 Years70 YearsBoth12Phase 1NULL
854NCT00888745
(ClinicalTrials.gov)
May 200927/4/2009A Study of the Safety and Pharmacokinetics of PRO283698 in Patients With Rheumatoid ArthritisA Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Safety and Pharmacokinetics of PRO283698 in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: placebo;Drug: PRO283698Genentech, Inc.NULLCompleted18 Years75 YearsBoth65Phase 1United States;Hungary;United Kingdom
855NCT00891020
(ClinicalTrials.gov)
May 200929/4/2009A Study Of Tocilizumab in Patients With Moderate to Severe Active Rheumatoid Arthritis Who Have an Inadequate Response to or Are Unable to Tolerate Biologic and Non-Biologic Disease-modifying Antirheumatic Drugs (DMARDs)Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis on Background Non-biologic DMARDs and Monotherapy Who Have an Inadequate Response to Current Non-Biologic or Biologic DMARDsRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: Nonbiologic DMARDs of investigator's choiceHoffmann-La RocheNULLCompleted18 YearsN/AAll886Phase 3United States;Puerto Rico;United Kingdom
856NCT00853385
(ClinicalTrials.gov)
May 200927/2/2009A Phase 3 Study Comparing 2 Doses Of CP-690,550 And The Active Comparator, Humira (Adalimumab) Vs. Placebo For Treatment Of Rheumatoid ArthritisPhase 3 Randomized, Double-Blind, Active Comparator, Placebo-Controlled Study Of The Efficacy And Safety Of 2 Doses Of CP 690,550 In Patients With Active Rheumatoid Arthritis On Background MethotrexateRheumatoid ArthritisDrug: CP 690,550;Drug: CP-690,550;Other: Placebo;Biological: Biologic TNFiPfizerNULLCompleted18 YearsN/AAll717Phase 3United States;Australia;Bosnia and Herzegovina;Bulgaria;Canada;Chile;Costa Rica;Croatia;Czech Republic;Denmark;Dominican Republic;Finland;Germany;Korea, Republic of;Mexico;Philippines;Poland;Slovakia;Spain;Thailand;United Kingdom
857NCT00279461
(ClinicalTrials.gov)
May 200917/1/2006Vitamin D Deficiency Causes Immune Dysfunction and Enables or Perpetuates the Development of Rheumatoid ArthritisVitamin D Deficiency Causes Immune Dysfunction and Enables or Perpetuates the Development of Rheumatoid Arthritis: Clinical Trial and Investigations on Dendritic CellsArthritis, Rheumatoid;Vitamin D DeficiencyDrug: Placebo in arm A and Vitamin D in arm B;Drug: vitamin D 3 for arm A ,and matching placebo for arm BIndiana UniversityNULLWithdrawn18 YearsN/ABoth0Phase 2United States
858NCT00856544
(ClinicalTrials.gov)
May 20093/3/2009A Study Comparing 2 Doses Of CP-690,550 Vs. Placebo For The Treatment Of Rheumatoid Arthritis In Patients On Other Background Arthritis MedicationsPhase 3, Randomized, Double Blind, Placebo Controlled Study Of The Safety And Efficacy Of 2 Doses Of CP 690,550 In Patients With Active Rheumatoid Arthritis On Background DMARDSArthritis, RheumatoidDrug: CP-690,550;Drug: PlaceboPfizerNULLCompleted18 YearsN/AAll795Phase 3United States;Australia;Chile;China;Colombia;Croatia;Denmark;Finland;Germany;Greece;Malaysia;Mexico;Poland;Russian Federation;Slovakia;Spain;Sweden;Thailand;United Kingdom;Venezuela
859NCT00902369
(ClinicalTrials.gov)
May 200914/5/2009A Study of AK106-001616 in Patients With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: AK106-001616;Drug: Placebo;Drug: Active comparatorAsahi Kasei Pharma CorporationNULLCompleted18 Years65 YearsBoth130Phase 2Czech Republic;Germany;Hungary;Lithuania;Romania;United Kingdom
860NCT01081717
(ClinicalTrials.gov)
April 14, 20094/3/2010Golimumab Safety and Surveillance Program Using the Ingenix NHI DatabaseA Large US Health Insurance Claims Database Will be Used to Estimate the Incidence of Serious Outcomes in Patients With Rheumatoid Arthritis, Psoriatic Arthritis, or Ankylosing Spondylitis Treated With Golimumab and Other Types of Biological and Systemic Non Biological TreatmentsRheumatoid Arthritis;Arthritis, Psoriatic;Ankylosing SpondylitisDrug: systemic non-biological treatments;Biological: anti-TNF biologics;Biological: golimumab;Biological: non-anti-TNF biologics;Other: general populationJanssen Biotech, Inc.NULLCompletedN/A99 YearsAll1064United States
861NCT01075711
(ClinicalTrials.gov)
April 200924/2/2010Determine the Improvement in Activity Status/Quality of Life (QoL) of Patients With Rheumatoid Arthritis (RA) During Treatment With Lodotra (Prednisone)Non-interventional Study for Determining the Improvement in the Activity Status / Life Quality of Patients With Rheumatoid Arthritis Being Treated With the Tempus TabletArthritis, RheumatoidDrug: PrednisoneMerck KGaAMerck Serono GmbH, GermanyCompleted18 YearsN/ABoth2728N/AGermany
862NCT00763139
(ClinicalTrials.gov)
April 200926/9/2008Inflammation and Insulin Resistance in Rheumatoid ArthritisInflammation and Insulin Resistance in Rheumatoid ArthritisRheumatoid ArthritisDrug: Pioglitazone;Drug: PlaceboVanderbilt UniversityNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed18 YearsN/AAll34N/AUnited States
863NCT00887770
(ClinicalTrials.gov)
April 200923/4/2009A Study to Investigate the Potential for AZD5672 to Affect the Electrical Conduction Pathways in the HeartA Single-centre, Double-blind, Double-dummy, Randomised, Placebo-controlled, Four-period Crossover Study to Assess the Effect of Single Oral Doses of AZD5672 (600 mg and 150 mg) on QT/QTc Interval, Compared to Placebo, Using Moxifloxacin (Avelox®) as a Positive Control, in Healthy Male VolunteersRheumatoid ArthritisDrug: AZD5672;Drug: Moxifloxacin;Drug: placeboAstraZenecaQuintiles LimitedCompleted18 Years45 YearsMale64Phase 1United Kingdom
864NCT00931086
(ClinicalTrials.gov)
April 200930/6/2009Expanded Access Trial of Belimumab Antibody in RA Patients Who Were Previously Treated Under HGS Protocol LBRA99An Expanded Access Trial of Belimumab Antibody (Monoclonal Anti-BLyS Antibody) in Patients With Rheumatoid Arthritis (RA) Who Were Previously Treated Under HGS Protocol LBRA99Rheumatoid ArthritisDrug: belimumabHuman Genome Sciences Inc., a GSK CompanyGlaxoSmithKlineNo longer available18 YearsN/ABothPhase 4United States
865NCT00928317
(ClinicalTrials.gov)
April 200924/6/2009Dose Ranging Study of ART621 in Subjects Diagnosed With Rheumatoid Arthritis Taking MethotrexateMulti-Centre Randomised Double-Blind Pbo-Controlled Dose-Ranging Study to Evaluate the Safety, Tolerability, Efficacy, PK and Immunogenicity of Multiple Doses of ART621 for 3 Months in Patients With Rheumatoid Arthritis Taking MethotrexateRheumatoid ArthritisDrug: ART621;Drug: PlaceboArana Therapeutics LtdNULLTerminated18 Years80 YearsBoth13Phase 2United States;Argentina;Australia;Czech Republic;India;Malaysia;New Zealand;Poland
866NCT00808210
(ClinicalTrials.gov)
March 5, 200911/12/2008A Study to Evaluate Ocrelizumab in Combination With Methotrexate Compared With Infliximab Plus Methotrexate in Patients With Active Rheumatoid Arthritis Currently Responding Inadequately to Etanercept or AdalimumabA PHASE II RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF OCRELIZUMAB IN COMBINATION WITH METHOTREXATE, COMPARED TO INFLIXIMAB PLUS METHOTREXATE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS CURRENTLY RESPONDING INADEQUATELY TO ETANERCEPT OR ADALIMUMABRheumatoid ArthritisDrug: Infliximab;Drug: Methotrexate;Drug: Methylprednisolone;Drug: Ocrelizumab;Drug: PlaceboGenentech, Inc.NULLTerminated18 YearsN/AAll28Phase 2United States
867NCT00845832
(ClinicalTrials.gov)
March 200917/2/2009A Study of Combination Treatment With MabThera (Rituximab) and RoActemra (Tocilizumab) Versus RoActemra in Patients With Rheumatoid Arthritis With an Incomplete Response to MethotrexateA Randomized, Active Controlled, Double-blind, Study to Compare the Safety and Reduction in Disease Activity With the Combination of Rituximab (MabThera®)and Tocilizumab (RoActemra®) Versus Tocilizumab in Patients With Active Rheumatoid Arthritis With an Incomplete Response to MethotrexateRheumatoid ArthritisDrug: Placebo;Drug: rituximab [MabThera/Rituxan];Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLTerminated18 Years65 YearsAll24Phase 2France;Germany;Greece;Netherlands;Poland;Spain;Switzerland;United Kingdom;Belgium;Sweden
868NCT00847613
(ClinicalTrials.gov)
March 200917/2/2009A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background MethotrexatePhase 3 Randomized, Double Blind, Placebo Controlled Study Of The Efficacy And Safety Of 2 Doses Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background MethotrexateArthritis, RheumatoidDrug: CP-690,550;Drug: PlaceboPfizerNULLCompleted18 YearsN/AAll800Phase 3United States;Australia;Brazil;Bulgaria;Canada;Colombia;Czech Republic;Greece;India;Japan;Korea, Republic of;Mexico;Poland;Taiwan;Ukraine;Venezuela
869NCT00837434
(ClinicalTrials.gov)
March 20093/2/2009Anti-TNF Agents for the Treatment of Rheumatoid ArthritisA Partially Blinded, Randomized, Multi-Center, Phase IV Trial to Evaluate Mechanism of Action of Anti-TNF Agents in Rheumatoid ArthritisRheumatoid ArthritisDrug: Etanercept;Drug: AdalimumabNational Institute of Allergy and Infectious Diseases (NIAID)Autoimmunity Centers of ExcellenceCompleted18 Years75 YearsAll63Phase 4United States
870NCT00883753
(ClinicalTrials.gov)
March 200917/4/2009An Extension to Study MA21573, Evaluating Tocilizumab in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biological DMARDs and/or Anti-tumor Necrosis Factor (TNF) TherapyAn Extension Phase of the Multi-National Open-Label Study (MA21573) to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis on Background Non-biologic DMARDs Who Have an Inadequate Response to Current Non-biologic DMARD and/or Anti-TNF Therapy.Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll934Phase 3Australia;Canada;Czech Republic;France;Greece;Hungary;Italy;Netherlands;Poland;Portugal;Romania;Saudi Arabia;Spain;United Kingdom;Austria;Turkey
871NCT00882024
(ClinicalTrials.gov)
March 200914/4/2009Safety and Efficacy Study of Tranilast in Patients With Active Rheumatoid Arthritis (RA)A Phase II, Randomized Multi-Center, Double-Blind Study of Tranilast With Concomitant Methotrexate (MTX) Compared to MTX Alone in Patients With Active Rheumatoid Arthritis (RA)Active Rheumatoid ArthritisDrug: Tranilast;Drug: PlaceboNuon Therapeutics, Inc.NULLCompleted18 Years75 YearsBoth250Phase 2United States;Argentina;Bulgaria;Czech Republic;Germany;Mexico;Serbia;United Kingdom
872NCT00687193
(ClinicalTrials.gov)
March 200922/5/2008Comparison Of 5 CP-690,550 Doses Vs. Placebo, For The Treatment Of Rheumatoid Arthritis In JapanA Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Confirm Dose Responsiveness Following 12 Weeks Of The Administration Of CP-690,550 (5 Doses) Or Placebo In Subjects With Active Rheumatoid Arthritis Inadequately Responding To At Least 1 DMARDArthritis, RheumatoidDrug: Placebo;Drug: CP-690,550PfizerNULLCompleted20 Years70 YearsAll318Phase 2Japan
873NCT00851318
(ClinicalTrials.gov)
March 200923/2/2009Long-term Treatment Study of Certolizumab Pegol (CDP870) as Add-on Medication to Methotrexate in Japanese Rheumatoid Arthritis (RA) PatientsA Multicenter, Open-label, Long-term Safety Study of CDP870 to Evaluate the Safety and Efficacy of CDP870 Administered in Combination With Methotrexate (MTX) Over the Long Term in Patients With Active Rheumatoid Arthritis Transferred From the Efficacy Confirmatory Study (Study 275-08-001)Rheumatoid ArthritisDrug: Certolizumab pegol;Drug: MethotrexateAstellas Pharma IncUCB Japan Co. Ltd.Completed20 Years74 YearsAll285Phase 3Japan
874NCT00850343
(ClinicalTrials.gov)
March 200923/2/2009Long-term Treatment Study of Certolizumab Pegol Without Coadministration of Methotrexate in Japanese Rheumatoid Arthritis (RA) PatientsA Multicenter, Open-label, Long-term Safety Study of CDP870 to Evaluate the Safety and Efficacy of CDP870 Administered Without Coadministration of Methotrexate (MTX) Over the Long Term in Patients With Active Rheumatoid Arthritis Transferred From the Efficacy Confirmatory Study (Study 275-08-003)Rheumatoid ArthritisDrug: Certolizumab pegolAstellas Pharma IncUCB Japan Co. Ltd.Completed20 Years74 YearsAll208Phase 3Japan
875NCT00810199
(ClinicalTrials.gov)
March 200916/12/2008A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate TreatmentRandomized Placebo-controlled Study of Two Treatment Strategies Based on Tocilizumab (TCZ) With or Without Methotrexate (MTX) and Possible Addition of Other Disease-modifying Anti-rheumatic Drugs (DMARDs) in Patients...Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: methotrexate;Drug: placeboHoffmann-La RocheNULLCompleted18 YearsN/AAll556Phase 3United States;Brazil;Croatia;Denmark;Estonia;France;Germany;Greece;Israel;Italy;Latvia;Netherlands;Norway;Romania;Russian Federation;Serbia;Spain;Sweden;Thailand;United Kingdom;Monaco
876NCT02721004
(ClinicalTrials.gov)
March 20092/3/2016Efficacy and Safety Study of RoActemra (Tocilizumab) in Participants With Rheumatoid ArthritisDocumentation of the Efficacy and Safety of RoActemra in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompletedN/AN/ABoth592N/AAustria
877NCT00871767
(ClinicalTrials.gov)
March 200926/3/2009AZD5672 Bioavailability Study in Healthy Male and Female SubjectsAn Open-Label, Randomized, 4 Period Crossover, Replicate Study to Assess the Relative Bioavailability of the Phase III and Phase IIb Formulations of AZD5672 in Healthy Male and Female SubjectsRheumatoid ArthritisDrug: AZD5672AstraZenecaNULLCompleted18 Years55 YearsBoth24Phase 1United Kingdom
878NCT01172639
(ClinicalTrials.gov)
February 200928/7/2010Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis.A 2 Year Prospective Multicentre Randomised Controlled Trial Comparing Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis.Rheumatoid ArthritisDrug: Methotrexate;Drug: Sulfasalazine;Drug: Leflunomide;Drug: PrednisoneP. VerschuerenAgentschap voor Innovatie door Wetenschap en TechnologieCompleted18 YearsN/AAll400Phase 4Belgium
879NCT00814307
(ClinicalTrials.gov)
February 200922/12/2008A Phase 3 Study Comparing 2 Doses of CP-690,550 vs. Placebo for Treatment of Rheumatoid ArthritisPhase 3, Randomized, Double-Blind, Placebo-Controlled Study Of The Efficacy And Safety Of 2 Doses Of CP-690,550 Monotherapy In Patients With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: CP-690,550;Drug: PlaceboPfizerNULLCompleted18 YearsN/AAll611Phase 3United States;Brazil;Bulgaria;Chile;Colombia;Czech Republic;Dominican Republic;Germany;India;Malaysia;Mexico;Philippines;Poland;Puerto Rico;Russian Federation;Ukraine
880NCT00851240
(ClinicalTrials.gov)
February 20092/2/2009BTT-1023 in Rheumatoid ArthritisA Multiple Ascending Dose Study to Assess the Safety and Pharmacokinetics of Repeated Intravenous Doses of BTT-1023 in Patients With Rheumatoid Arthritis - a Double-blind Randomized Placebo-controlled Sequential Group TrialRheumatoid ArthritisDrug: BTT-1023;Drug: PlaceboBiotie Therapies Corp.NULLCompleted18 Years75 YearsBoth24Phase 1Bulgaria
881NCT00854685
(ClinicalTrials.gov)
February 20091/3/2009Dose Optimisation Study of ART621 in Subjects Diagnosed With Rheumatoid Arthritis Taking MethotrexateA Factorial-design, Randomised, Double-blind, Placebo-controlled, Dose Optimisation Study to Investigate the Safety, Efficacy, Immunogenicity and Pharmacokinetics of ART621 Following Multiple Dose Administration in Subjects Diagnosed With Rheumatoid Arthritis Concomitantly Taking MethotrexateRheumatoid ArthritisDrug: ART621;Drug: PlaceboArana Therapeutics LtdTrident Clinical Research Pty LtdCompleted18 Years80 YearsBoth27Phase 2Sri Lanka
882NCT00754572
(ClinicalTrials.gov)
February 200917/9/2008A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid ArthritisA Single-arm, Open-label Study of the Safety and Reduction of Signs and Symptoms During Treatment With Tocilizumab in Combination With Methotrexate, in Patients With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: methotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll418Phase 3Argentina;Brazil;Chile;Colombia;Costa Rica;Ecuador;Mexico;Peru;Uruguay;Venezuela
883NCT00847886
(ClinicalTrials.gov)
February 200917/2/2009Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid ArthritisA Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Determine the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of LX3305 and Methotrexate in Subjects With Stable Rheumatoid ArthritisRheumatoid ArthritisDrug: LX3305;Drug: LX3305 Placebo;Drug: MethotrexateLexicon PharmaceuticalsNULLCompleted18 YearsN/AAll15Phase 1United States
884NCT00777816
(ClinicalTrials.gov)
February 200917/10/2008Safety and Pharmacokinetics Study of XOMA 052 in Subjects With Active, Stable, Moderate to Severe Rheumatoid ArthritisA Blinded, Placebo-controlled, Study of the Safety and Pharmacokinetics of XOMA 052 Administered to Subjects With Active, Stable, Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: XOMA 052;Drug: PlaceboXOMA (US) LLCNULLSuspended18 Years75 YearsBoth18Phase 2United States
885NCT02809833
(ClinicalTrials.gov)
January 200920/6/2016Use of Tocilizumab for Rheumatoid Arthritis (RA) in Daily RoutineTocilizumab for the Treatment of Rheumatoid Arthritis: Findings on The Use of Tocilizumab in Daily Clinical RoutineRheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll850N/AGermany
886NCT00838058
(ClinicalTrials.gov)
January 20092/2/2009A Study in Normal Healthy People, Testing Different Versions of a Pill That Will be Used to Treat Rheumatoid Arthritis.An Open-Label Two-Part Randomized, Crossover Study Of The Pharmacokinetics Of CE-224,535 Administered As Controlled And Immediate Release Formulations In Healthy VolunteersRheumatoid Arthritis;Healthy VolunteersDrug: CE-224,535;Drug: CE 224,535PfizerNULLCompleted18 Years55 YearsBoth11Phase 1United States
887NCT02779114
(ClinicalTrials.gov)
January 200916/5/2016RETRO (REduction of Therapy in RA Patients in Ongoing Remission)A Phase 3, Multicenter, Randomized, Open, Prospective, Controlled, Parallel Group Study of Reduction of Therapy in Patients With Rheumatoid Arthritis in Ongoing Remission.Rheumatoid ArthritisDrug: Control group;Other: Reduction group 1;Other: Reduction group 2University of Erlangen-Nürnberg Medical SchoolNULLRecruiting18 YearsN/ABoth318Phase 3Germany
888NCT01426347
(ClinicalTrials.gov)
January 200929/8/2011Treatment of Vitamin D Deficiency in Patients With Rheumatoid ArthritisVitamin Therapy in Rheumatoid ArthritisRheumatoid Arthritis;Vitamin D DeficiencyDrug: Placebo sugar pill;Drug: ErgocalciferolJohns Hopkins UniversityNULLCompleted18 Years75 YearsAll139N/AUnited States
889NCT00858780
(ClinicalTrials.gov)
January 20096/3/2009Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RADose Reduction or Discontinuation of Etanercept in Methotrexate-Treated Rheumatoid Arthritis Subjects Who Have Achieved a Stable Low Disease Activity-state (DOSERA)Rheumatoid ArthritisDrug: Etanercept;Drug: PlaceboPfizerNULLCompleted18 YearsN/AAll91Phase 4Denmark;Finland;Hungary;Iceland;Norway;Sweden
890NCT00848120
(ClinicalTrials.gov)
December 31, 200819/2/2009A Study to Assess the Effect of Tocilizumab on Signs and Symptoms in Patients With Rheumatoid ArthritisAn Open Label Study to Evaluate the Safety and Reduction in Signs and Symptoms During Treatment With Tocilizumab in Patients With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll29Phase 3Philippines
891NCT00767325
(ClinicalTrials.gov)
December 20086/10/2008A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler UltrasonographyMulti-Center, Open Label Study to Assess Early Response to Abatacept With Background Methotrexate Using Power Doppler Ultrasonography in Patients With Active Rheumatoid Arthritis and Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Abatacept;Drug: MethotrexateBristol-Myers SquibbNULLCompleted18 YearsN/AAll104Phase 3Denmark;France;Germany;Hungary;Italy;Norway;Spain;United Kingdom
892NCT00818064
(ClinicalTrials.gov)
December 200830/12/2008Safety and Tolerability of Anti-IL-20 in Healthy Volunteers and Patients With Rheumatoid ArthritisA Randomised, Double-blind, Placebo-controlled, Single- Dose, Dose-escalation Trial of Anti-IL-20 in Healthy Volunteers and Patients With Rheumatoid ArthritisInflammation;Rheumatoid Arthritis;HealthyDrug: anti-IL-20;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years75 YearsAll32Phase 1Netherlands
893NCT00815906
(ClinicalTrials.gov)
December 200818/12/2008Study Evaluating Single Doses Of SBI-087 In Japanese Subjects With Rheumatoid ArthritisAn Ascending Single Dose Study Of The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of SBI-087 Administered To Japanese Subjects With Rheumatoid ArthritisArthritis, RheumatoidDrug: SBI-087PfizerEmergent Product Development Seattle LLCCompleted20 Years70 YearsBoth20Phase 1Japan
894NCT00810836
(ClinicalTrials.gov)
December 200817/12/2008Efficacy and Safety Study of BG00012 With Methotrexate in Patients With Active Rheumatoid ArthritisA Phase 2a, Randomised, Double-Blind, Placebo-Controlled, Multicentre Study to Evaluate the Efficacy, Safety and Tolerability of BG00012 When Given With Methotrexate to Subjects With Active RA Who Have Had an Inadequate Response to Conventional Disease-Modifying Anti-rheumatic Drug TherapyRheumatoid ArthritisDrug: BG00012;Drug: placeboBiogen IdecNULLCompleted18 Years75 YearsBoth153Phase 2Australia;Canada;Czech Republic;India;Poland;Slovakia
895NCT00810277
(ClinicalTrials.gov)
November 30, 200816/12/2008A Study of Tocilizumab in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic DMARDsAn Open Label Study to Evaluate the Safety and Effect on Disease Activity of Tocilizumab in Patients With Active Rheumatoid Arthritis on Background Non-biologic DMARDs Who Have an Inadequate Response to Current Non-biologic DMARDs.Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll14Phase 3Finland
896NCT00796705
(ClinicalTrials.gov)
November 200820/11/2008Switching Anti-TNF-Alpha Agents in Rheumatoid Arthritis (RA)Switching Anti-TNF-alpha Agents in Patients With RA With An Inadequate Response to TNF-alpha InhibitionRheumatoid ArthritisDrug: Adalimumab;Drug: Adalimumab placebo;Drug: EtanerceptNational Institute of Allergy and Infectious Diseases (NIAID)NULLTerminated18 YearsN/AAll13Phase 4United States
897NCT00901550
(ClinicalTrials.gov)
November 200813/5/2009The Chinese University of Hong Kong Early Arthritis StudyThe Chinese University of Hong Kong Early Arthritis StudyRheumatoid ArthritisDrug: Methotrexate;Drug: InfliximabChinese University of Hong KongNULLCompleted18 Years80 YearsBoth40N/AChina
898NCT00771030
(ClinicalTrials.gov)
November 20089/10/2008Multiple-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of AMG 827 in Subjects With Rheumatoid ArthritisA Randomized, Double-blind, Placebo-controlled, Ascending Multiple-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of AMG 827 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: AMG 827;Other: PlaceboAmgenNULLCompleted18 Years70 YearsBoth40Phase 1/Phase 2Canada;Mexico;United States
899NCT00783536
(ClinicalTrials.gov)
November 200829/10/2008A Multicenter Study to Compare the Efficacy and Safety of the Combination of Etanercept and Methotrexate in Treatment of Rheumatoid ArthritisAn Randomized, Open Label, Multicenter Study to Compare the Efficacy and Safety of the Combination of Etanercept and Methotrexate With DMARD Therapy in Subjects With Active Early Rheumatoid ArthritisRheumatoid ArthritisDrug: Etanercept + Methotrexate;Drug: DMARDSWyeth is now a wholly owned subsidiary of PfizerNULLWithdrawn18 Years80 YearsAll0Phase 4NULL
900NCT00791999
(ClinicalTrials.gov)
November 200814/11/2008Efficacy Confirmation Trial of CDP870 as add-on Medication to Methotrexate (MTX) in Japanese Rheumatoid Arthritis (RA)A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Assess the Efficacy, Pharmacokinetics and Safety of CDP870 as add-on Medication to MTX in Japanese Active RA Patients Who Have an Incomplete Response to MTX.Rheumatoid ArthritisDrug: CDP870 400mg;Drug: CDP870 200mg;Drug: CDP870 100mg;Drug: Placebo of CDP870Otsuka Pharmaceutical Co., Ltd.UCB Japan Co. Ltd.Completed20 Years74 YearsAll316Phase 2/Phase 3Japan
901NCT00791921
(ClinicalTrials.gov)
November 200814/11/2008Efficacy Confirmation Trial of CDP870 Without Coadministration of Methotrexate (MTX) in Japanese Rheumatoid Arthritis (RA)A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Trial to Assess the Efficacy, Pharmacokinetics, and Safety of CDP870 Without Coadministration of MTX in Japanese Active RA Patients in Whom MTX Cannot be Administrated.Rheumatoid ArthritisDrug: CDP870;Drug: Placebo of CDP870Otsuka Pharmaceutical Co., Ltd.UCB Japan Co. Ltd.Completed20 Years74 YearsAll230Phase 3Japan
902NCT00948610
(ClinicalTrials.gov)
November 200828/7/2009Sleep and Immunity in Rheumatoid Arthritis : Remicade SubstudySleep & Immune Mechanisms in Rheumatoid Arthritis: Remicade SubstudyRheumatoid ArthritisDrug: RemicadeUniversity of California, Los AngelesNational Heart, Lung, and Blood Institute (NHLBI)Completed18 Years85 YearsAll20N/AUnited States
903NCT00773461
(ClinicalTrials.gov)
October 31, 200815/10/2008A Study of Tocilizumab in Combination With DMARD Therapy in Patients With Active Rheumatoid Arthritis.A Randomized, Double Blind Study of Safety and Reduction in Signs and Symptoms During Treatment With Tocilizumab Versus Placebo, in Combination With DMARD Therapy, in Patients With Active Rheumatoid Arthritis and Inadequate Response to Current DMARD TherapyRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: PlaceboHoffmann-La RocheNULLCompleted18 Years70 YearsAll209Phase 3China
904NCT00771329
(ClinicalTrials.gov)
October 200810/10/2008BIIB023 (Anti-TWEAK) in Subjects With Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled, Single-Dose, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB023 (Anti-TWEAK) Administered to Subjects With Rheumatoid Arthritis.Rheumatoid ArthritisDrug: BIIB023;Other: Placebo (sterile normal saline)Biogen IdecNULLCompleted18 Years65 YearsBoth53Phase 1United States;Russian Federation;Ukraine
905NCT00779220
(ClinicalTrials.gov)
October 200823/10/2008A Study to Evaluate the Efficacy, Safety and Pharmacokinetics/Pharmacodynamics (PK/PD) of Ocrelizumab in Patients With Rheumatoid ArthritisA Randomized, Double-blind, Parallel-group, Study to Evaluate the Efficacy, Safety and PK/PD of Ocrelizumab in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate TherapyRheumatoid ArthritisDrug: placebo;Drug: methotrexate;Drug: ocrelizumabu 50mg;Drug: ocrelizumabu 200mg;Drug: ocrelizumab 500mgChugai PharmaceuticalNULLTerminated20 YearsN/ABoth152Phase 2Japan
906NCT00768053
(ClinicalTrials.gov)
October 20083/10/2008Evaluation of EULAR-RAID Score in Rheumatoid Arthritis PatientsOpen-Label Study To Evaluate The EULAR-RAID Score, Rheumatoid Arthritis Impact Of Disease Score, In Rheumatoid Arthritis Patients Eligible To Etanercept And Who Will Receive EtanerceptRheumatoid ArthritisDrug: EtanerceptWyeth is now a wholly owned subsidiary of PfizerLincoln Medical and Mental Health Center;Umanis;SODIA;depolaboCompleted18 YearsN/AAll108Phase 4France;Monaco
907NCT00771420
(ClinicalTrials.gov)
October 200810/10/2008A Single Dose Study of the CAM-3001 in Patients With Rheumatoid ArthritisA Double-blind, Placebo-controlled, Single Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CAM-3001 in Patients With Rheumatoid Arthritis.Rheumatoid ArthritisDrug: CAM-3001;Other: PlaceboMedImmune LtdNULLCompleted18 Years70 YearsBoth38Phase 1Germany
908NCT00746512
(ClinicalTrials.gov)
September 20083/9/2008A Study of the Effects of Oral Prednisone in Patients With Rheumatoid Arthritis (MK0000-088)A Randomized, Double-Blind, Parallel Group, Placebo Controlled Study to Access the Effects of Oral Prednisone on Clinical Efficacy and the Power Doppler Ultrasound Signal of Synovium in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Prednisone 15 mg;Drug: Placebo Tablets;Drug: Prednisone 7.5 mg;Drug: Placebo Over-Encapsulated TabletsMerck Sharp & Dohme Corp.NULLCompleted18 YearsN/AAll45Phase 1United Kingdom
909NCT00706797
(ClinicalTrials.gov)
September 200825/6/2008Study Evaluating Efficacy / Safety of Etanercept + Methotrexate Compared to Usual Treatment in Moderate RA SubjectsAn Open-Label, Randomized Study to Evaluate the Radiographic Efficacy and Safety of Enbrel™ (Etanercept) Added to Methotrexate in Comparison With Usual Treatment in Subjects With Moderate Rheumatoid Arthritis Disease ActivityRheumatoid ArthritisDrug: etanercept (EnbrelTM);Drug: methotrexateWyeth is now a wholly owned subsidiary of PfizerNULLTerminated18 YearsN/AAll141Phase 4Czech Republic;France;Germany;Hungary;Italy;Poland;Spain;Turkey;United Kingdom;Austria;Croatia;United States
910NCT01026519
(ClinicalTrials.gov)
September 20082/12/2009A Safety and Tolerability Study of REGN88(SAR153191) in Subjects With Rheumatoid ArthritisA Single-dose, Double-Blind, Placebo-Controlled, Parallel Group Safety, Tolerability and Pharmacodynamic Study of Subcutaneous REGN88 in Subjects With Rheumatoid Arthritis Receiving Concomitant MethotrexateRheumatoid ArthritisDrug: REGN88;Other: PlaceboRegeneron PharmaceuticalsSanofiCompleted18 YearsN/ABoth32Phase 1Russian Federation
911NCT00717808
(ClinicalTrials.gov)
September 200814/7/2008Effects of Tranilast on Pharmacokinetics of Methotrexate (MTX) in Patients With Rheumatoid Arthritis (RA)A Phase 1, Blinded, Randomised, Crossover Pilot Study to Investigate the Safety, Tolerability and Pharmacokinetics of Tranilast in Patients With Rheumatoid Arthritis on MethotrexateRheumatoid ArthritisDrug: Tranilast;Drug: Placebo comparatorImperial College LondonNuon Therapeutics, Inc.Withdrawn18 Years75 YearsBoth0Phase 1United Kingdom
912NCT00753454
(ClinicalTrials.gov)
September 20085/6/2008Open Label Extension for Patients Coming From the Dosing Flexibility Study in Patients With Rheumatoid Arthritis (RA)A Phase IIIb, Multi-center Open-label, Follow-up Study to Evaluate the Safety and Efficacy of Certolizumab Pegol Administered Concomitantly With Methotrexate in Patients With Active Rheumatoid Arthritis Who Participated in C87077.Rheumatoid ArthritisDrug: Certolizumab pegolUCB PharmaNULLCompleted18 YearsN/AAll168Phase 3United States;Canada
913NCT00724672
(ClinicalTrials.gov)
September 200825/7/2008A Study of Immune Cells in Patients With Rheumatoid Arthritis During Different Types of Anti-TNF Alpha Treatments (Study P05521)Whole Human Genome Oligo Microarray Analysis of the Peripheral Blood Mononuclear Cells of Patients With Rheumatoid Arthritis During Different Forms of Anti-Tumor Necrosis-Alpha Treatments.Rheumatoid ArthritisDrug: etanercept;Drug: infliximab;Drug: adalimumabMerck Sharp & Dohme Corp.NULLWithdrawn18 YearsN/ABoth0N/ANULL
914NCT00780793
(ClinicalTrials.gov)
September 200827/10/2008Spacing of TNF-blocker Injections in Rheumatoid Arthritis StudyEffect of TNF-blocker Injections Spacing on Rheumatoid Arthritis Inflammatory Activity in Patients in Clinical Remission or Low Disease ActivityRheumatoid ArthritisDrug: progressive spacing of TNF-blocker injections;Drug: DMARD maintenanceAssistance Publique - Hôpitaux de ParisFrench Society of RheumatologyCompleted18 YearsN/ABoth250Phase 4France
915NCT00814866
(ClinicalTrials.gov)
September 200823/12/2008Bone Resorption, Osteoclastogenesis and AdalimumabBone Resorption, Osteoclastogenesis and AdalimumabRheumatoid ArthritisDrug: AdalimumabUniversité de SherbrookeAbbottCompleted18 YearsN/ABoth28N/ACanada
916NCT00750880
(ClinicalTrials.gov)
September 200810/9/2008An Exploratory Study of Tocilizumab in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Current Non-Biologic DMARDs and/or Anti-TNF Therapy.International Multi-Center Open Label Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis on Background Non-biologic DMARDs Who Have An Inadequate Response to Current Non-Biologic DMARD or Anti-TNF Therapy.Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/AAll1681Phase 3Australia;Austria;Belgium;Canada;Czech Republic;Denmark;Finland;France;Germany;Greece;Hungary;India;Ireland;Italy;Luxembourg;Netherlands;Poland;Portugal;Romania;Saudi Arabia;Spain;Sweden;Switzerland;Turkey;United Kingdom;United States
917NCT00718718
(ClinicalTrials.gov)
August 11, 200817/7/2008A Study of Effectiveness and Safety of CNTO 136 in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyA Phase 2, 2-Part, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled, Proof-of-concept, Dose-finding Study Evaluating the Efficacy and Safety of CNTO 136 Administered Subcutaneously in Subjects With Active Rheumatoid Arthritis Despite Methotrexate TherapyArthritis, RheumatoidDrug: CNTO 136 100 mg;Drug: CNTO 136 50 mg;Drug: CNTO 136 25 mg;Drug: Placebo;Drug: MethotrexateCentocor, Inc.NULLCompleted18 YearsN/AAll187Phase 2United States;Hungary;Japan;Korea, Republic of;Mexico;Poland;Russian Federation;Argentina;Taiwan;Ukraine
918NCT00754559
(ClinicalTrials.gov)
August 200817/9/2008A Study to Assess Efficacy With Respect to Clinical Improvement in Disease Activity and Safety of Tocilizumab in Patients Wtih Active Rheumatoid Arthritis.Effectiveness After Four and Twentyfour Weeks and Safety of Tocilizumab in Patients With Active RARheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll286Phase 3Germany
919NCT00805467
(ClinicalTrials.gov)
August 20085/12/2008Open-Label, Multicenter Extension Study for Patients Completing Treatment Phase of a Rigel-Sponsored R935788 StudiesAn Open-Label, Multicenter Extension Study to Evaluate the Safety of R935788 in Patients With Rheumatoid Arthritis Who Have Completed the Treatment Phase of a Rigel-Sponsored R935788 StudyRheumatoid ArthritisDrug: Fostamatinib Disodium (R935788)AstraZenecaNULLTerminated18 YearsN/AAll624Phase 2United States;Belgium;Bulgaria;Colombia;France;Germany;Italy;Mexico;Peru;Poland;Romania
920NCT00729209
(ClinicalTrials.gov)
July 20084/8/2008A Study of ARRY-371797 in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: ARRY-371797, p38 inhibitor; oral;Drug: PlaceboArray Biopharma, now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/AAll28Phase 1United States
921NCT00717236
(ClinicalTrials.gov)
July 200815/7/2008Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid ArthritisA Phase IIIb Multicenter Study With a 12-week Double-blind, Placebo-controlled, Randomized Period Followed by an Open-label, Extension Phase Evaluating Safety/Efficacy of Certolizumab Pegol Given to Patients With Active Rheumatoid Arthritis.Rheumatoid ArthritisDrug: Certolizumab pegol (CZP);Other: PlaceboUCB PharmaNULLCompleted18 YearsN/AAll1648Phase 3United States;Canada;France;Germany;Italy;Netherlands;Spain
922NCT00712114
(ClinicalTrials.gov)
July 20086/7/2008Safety, Tolerance, Pharmacokinetics and Activity of HE3286 in Patients With Rheumatoid ArthritisA Phase I/II, Open Label, Dose Ranging Study of the Safety, Tolerance, Pharmacokinetics and Potential Anti-Inflammatory Activity of HE3286 When Administered Orally for 29 Days to Patients With Rheumatoid Arthritis on a Stable Dose of MethotrexateRheumatoid ArthritisDrug: HE3286Harbor TherapeuticsNULLCompleted18 Years75 YearsBoth14Phase 1/Phase 2United States
923NCT00713544
(ClinicalTrials.gov)
July 20089/7/2008A Proof of Concept and Dose Ranging Study in Patients With Rheumatoid ArthritisA Randomised, Double Blind, Placebo Controlled, Phase IIb Dose Ranging Study (With Open-label Etanercept Treatment Group) to Investigate Efficacy, Safety and Pharmacokinetics of AZD5672 Administered for 12 Weeks to Rheumatoid Arthritis Patients Receiving Methotrexate.Rheumatoid ArthritisDrug: AZD5672;Drug: Etanercept;Drug: PlaceboAstraZenecaNULLCompleted18 YearsN/AAll373Phase 2Bulgaria;Colombia;Czech Republic;Hungary;Italy;Latvia;Malta;Poland;Romania;Russian Federation;Serbia;Slovakia;South Africa;Ukraine;Argentina;Netherlands;Peru
924NCT00718588
(ClinicalTrials.gov)
July 200816/7/2008A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MTRX1011A in Patients With Rheumatoid ArthritisA Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial, With a Single Ascending-Dose Stage Followed by a Multiple Ascending-Dose Stage, of the Safety, Pharmacokinetics, and Pharmacodynamics of Intravenous and Subcutaneous MTRX1011A in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: MTRX1011AGenentech, Inc.NULLTerminated18 Years80 YearsBoth66Phase 1United States
925NCT00782600
(ClinicalTrials.gov)
July 200827/10/2008Study of Controlled Release Formulations of CE-224,535 Against the Immediate Release Formulation in Normal VolunteersA Phase 1, Randomized, 4-Period, 4-Sequence Cross-Over Study Of The Pharmacokinetics Of 3 Durations Of Release Of A Controlled Release Formulation And A Single Dose Of An Immediate Release Oral Suspension Of CE-224,535 In Normal Healthy VolunteersRheumatoid ArthritisDrug: suspension IR;Drug: CR 1;Drug: CR 2;Drug: CR 3PfizerNULLCompleted18 Years55 YearsBoth16Phase 1United States
926NCT00147966
(ClinicalTrials.gov)
June 20082/9/2005Assessment of Rituximab's Immunomodulatory Synovial Effects (The ARISE Study)Assessment of the Immunomodulatory Effects of Rituximab in Seropositive Rheumatoid Arthritis Using Arthroscopic Synovial BiopsiesRheumatoid ArthritisDrug: rituximabUniversity of California, San DiegoGenentech, Inc.Completed18 Years75 YearsAll24Phase 2United States
927NCT02151409
(ClinicalTrials.gov)
June 200828/5/2014Dose-escalation Trial of Anti-C5aR Antibody in Healthy SubjectsA Randomised, Double-blind, Placebo-controlled, Single-dose, Dose-escalation Trial of Anti-C5aR Antibody (NNC 0151-0000-0000) Administered by i.v. Infusion or s.c. Injection in Healthy Subjects.Inflammation;Systemic Lupus Erythematosus;Rheumatoid Arthritis;HealthyDrug: NNC 0151-0000-0000;Drug: placeboNovo Nordisk A/SNULLCompleted18 Years55 YearsMale60Phase 1Netherlands
928NCT00711074
(ClinicalTrials.gov)
June 20083/7/2008Mass Balance and Metabolic Profiling of [14C]AZD5672 in Healthy Male VolunteersAn Open-Label, Phase I Study to Assess the Excretion of Radioactivity, Metabolic Profiles and Pharmacokinetics Following a Single Oral Dose of [14C]AZD5672 in Healthy Male VolunteersRheumatoid ArthritisDrug: AZD5672AstraZenecaNULLCompleted50 YearsN/AMale4Phase 1United Kingdom
929NCT00700986
(ClinicalTrials.gov)
June 200818/6/2008Cross-over Study to Investigate Retinal Function Following Administration of a Single Dose of AZD9056A Randomised, Double-Blind, Placebo-Controlled, 2-Period Cross-Over Study in Healthy Male Volunteers, to Investigate Retinal Function Following a Single 800mg Oral Dose of AZD9056Rheumatoid ArthritisDrug: AZD9056;Drug: PlaceboAstraZenecaNULLCompleted18 Years65 YearsMale12Phase 1United Kingdom
930NCT00665626
(ClinicalTrials.gov)
May 200822/4/2008Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis (Taski-3)A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Dose Study of R935788 in Patients With Rheumatoid Arthritis Who Have Failed at Least One BiologicRheumatoid ArthritisDrug: Fostamatinib disodium (R935788);Drug: PlaceboRigel PharmaceuticalsNULLCompleted18 YearsN/AAll219Phase 2United States;Belgium;Colombia;France;Germany;Italy;Peru;Brazil
931NCT00665925
(ClinicalTrials.gov)
May 200822/4/2008Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid ArthritisA Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Dose Study of Two Doses of R935788 in Rheumatoid Arthritis Patients Failing to Respond to MethotrexateRheumatoid ArthritisDrug: Fostamatinib disodium (R935788);Drug: PlaceboRigel PharmaceuticalsNULLCompleted18 YearsN/AAll457Phase 2United States;Bulgaria;Colombia;Mexico;Poland;Romania;Israel
932NCT00667758
(ClinicalTrials.gov)
May 200824/4/2008Gonadotropin-Releasing Hormone (GnRH)-Antagonist Therapy in Rheumatoid ArthritisAntagonist to Gonadotropin-Releasing Hormone in Rheumatoid Arthritis (AGRA): A Double-blind, Randomized, Placebo Controlled TrialRheumatoid ArthritisDrug: Cetrorelix;Drug: PlaceboBetanien HospitalNorwegian Foundation for Health and Rehabilitation;University of OsloCompleted18 YearsN/ABoth104Phase 2Norway
933NCT00695188
(ClinicalTrials.gov)
May 20089/6/2008Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid ArthritisMethotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid Arthritis A Multicenter, Randomized, Double-blind, Controlled Phase IV TrialRheumatoid ArthritisDrug: methotrexateLudwig-Boltzmann Institut fuer Rheumatologie, Balneologie und RehabilitationNULLCompleted18 YearsN/AAll19Phase 4Austria
934NCT00727987
(ClinicalTrials.gov)
May 200831/7/2008A Safety and Efficacy Study of Golimumab (CNTO 148) in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyA Study of Golimumab (CNTO 148) Administered in Combination With Methotrexate (MTX) in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CNTO 148;Drug: Placebo;Drug: Methotrexate (MTX)Janssen Pharmaceutical K.K.Mitsubishi Tanabe Pharma CorporationCompleted20 Years74 YearsBoth269Phase 3Japan
935NCT01224418
(ClinicalTrials.gov)
May 200814/10/2010A Study to Evaluate the Efficacy of Tacrolimus in Rheumatoid Arthritis Patients Shown Unsuccessful Response to MethotrexateClinical Study to Evaluate the Efficacy of Tacrolimus in Active Rheumatoid Arthritis Patients Shown Unsuccessful Response Against Methotrexate: Non-comparative, Single Arm, Multi-center, Phase 4 StudyRheumatoid ArthritisDrug: TacrolimusAstellas Pharma IncAstellas Pharma Korea, Inc.Completed18 Years75 YearsBoth50Phase 4Korea, Republic of
936NCT00771251
(ClinicalTrials.gov)
May 200810/10/2008A Safety and Efficacy Study of Golimumab (CNTO148) in Patients With Active Rheumatoid Arthritis (RA)A Study of Golimumab (CNTO148) Monotherapy in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CNTO 148;Drug: PlaceboJanssen Pharmaceutical K.K.Mitsubishi Tanabe Pharma Corporation;Mitsubishi Tanabe Pharma CorporationCompleted20 Years74 YearsBoth311Phase 3Japan
937NCT00673920
(ClinicalTrials.gov)
April 24, 20085/5/2008A Study to Evaluate Ocrelizumab Compared With Placebo in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate TherapyA Randomized, Double-Blind, Parallel-Group, International Study to Evaluate the Safety and Efficacy of Ocrelizumab Given As a Single Infusion or Dual Infusion Compared With Placebo in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate TherapyRheumatoid ArthritisDrug: Methotrexate;Drug: Ocrelizumab;Drug: PlaceboGenentech, Inc.Roche Pharma AGTerminated18 YearsN/AAll314Phase 3United States
938NCT00658047
(ClinicalTrials.gov)
April 20088/4/2008A Study to Assess CH1504 in Patients With Active Rheumatoid ArthritisA Phase II, Multi-center, Randomized, Double-blind, Methotrexate Controlled Study to Assess the Clinical Efficacy, Safety, and Tolerability of CH-1504 in Subjects With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: CH-1504;Drug: Methotrexate (MTX)Chelsea TherapeuticsNULLCompleted18 Years80 YearsBoth201Phase 2Canada
939NCT02622503
(ClinicalTrials.gov)
April 20082/12/2015A Study on Rheumatoid Arthritis Patients Treated With RituximabRetrospective Data Collection on Rheumatoid Arthritis (RA) Patients Treated With Rituximab in Finland.Rheumatoid ArthritisDrug: RituximabHoffmann-La RocheNULLCompletedN/AN/ABoth81N/AFinland
940NCT00661661
(ClinicalTrials.gov)
April 20087/2/2008Long-Term, Open-Label Study Of CP-690,550 For Treatment Of Rheumatoid Arthritis In JapanA Long-term, Open-label Study Of Cp-690,550 to Confirm The Safety Following Long Term Administration Of Cp-690,550 In The Treatment Of Rheumatoid ArthritisRheumatoid ArthritisDrug: CP-690,550PfizerNULLCompleted20 YearsN/AAll487Phase 3Japan
941NCT00674635
(ClinicalTrials.gov)
April 200822/4/2008Phase II Study Evaluating the Safety and Efficacy of GSK315234A in Patients With Rheumatoid ArthritisA Randomized, Double-blind, Placebo-controlled, Bayesian Adaptive Dose Finding Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Intravenous Infusions GSK315234A in Patients With Active Rheumatoid Arthritis (RA)Arthritis, RheumatoidDrug: GSK3152314A;Drug: PlaceboGlaxoSmithKlineNULLCompleted18 Years75 YearsBoth135Phase 2Australia;New Zealand;Russian Federation;Serbia;Ukraine;Former Serbia and Montenegro;United Kingdom
942NCT01000610
(ClinicalTrials.gov)
March 17, 200821/10/2009A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateAn Open Label Study to Evaluate the Safety and Efficacy of Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Prior Treatment With MethotrexateRheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: methotrexate;Drug: methylprednisoloneHoffmann-La RocheNULLCompleted18 YearsN/AAll18Phase 4Tunisia
943NCT02109666
(ClinicalTrials.gov)
March 20088/4/2014Long Term Experience With Abatacept in Routine Clinical PracticeLong Term Experience With Abatacept in Routine Clinical PracticeRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll2364N/AAustria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Spain;Switzerland
944NCT00628095
(ClinicalTrials.gov)
March 200825/2/2008Study of CE-224,535 A Twice Daily Pill To Control Rheumatoid Arthritis In Patients Who Have Not Totally Improved With MethotrexateA Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of CE-224,535, An Antagonist Of The P2x7 Receptor, In The Treatment Of The Signs And Symptoms Of Rheumatoid Arthritis In Subjects Who Are Inadequately Controlled On MethotrexateArthritis, RheumatoidDrug: CE-224,535;Drug: PlaceboPfizerNULLCompleted18 YearsN/ABoth100Phase 2/Phase 3United States;Chile;Czech Republic;Korea, Republic of;Mexico;Poland;Spain
945NCT00650767
(ClinicalTrials.gov)
March 200831/3/2008A Study of ARRY-438162 in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: ARRY-438162, MEK inhibitor; oral;Drug: PlaceboArray Biopharma, now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/AAll201Phase 2United States;Argentina;Brazil;Hungary;Peru;Poland;Romania
946NCT00650078
(ClinicalTrials.gov)
March 200828/3/2008Study to Assess the Safety and Efficacy of Modified-Release Prednisone (Lodotra®) Therapy in Patients With Active Rheumatoid ArthritisA Randomized Multi-Center, Double-Blind, Placebo-Controlled Study of a New Modified-Release Tablet Formulation of Prednisone (Lodotra®) in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: MR prednisone;Drug: PlaceboHorizon Pharma Ireland, Ltd., Dublin IrelandNULLCompleted18 Years80 YearsAll350Phase 3United States;Canada;Germany;Hungary;Poland;United Kingdom
947NCT00605735
(ClinicalTrials.gov)
March 200818/1/2008PoC in Rheumatoid Arthritis With MethotrexateA Randomized, Parallel Group, Double-Blind, Placebo-Controlled Study to Evaluate the Clinical Efficacy and Safety of BMS-582949 Given Orally to Subjects With Rheumatoid Arthritis Having an Inadequate Response to MethotrexateRheumatoid Arthritis, NOSDrug: BMS-582949;Drug: PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/ABoth121Phase 2United States;Argentina;Czech Republic;France;Korea, Republic of;Mexico;Spain;Taiwan;Brazil
948NCT00641225
(ClinicalTrials.gov)
March 200818/3/2008Study Evaluating Single Doses Of SBI-087 in Subjects With Rheumatoid ArthritisAn Ascending Single Dose Study Of The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of SBI-087 Administered To Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: SBI-087PfizerEmergent Product Development Seattle LLCCompleted18 Years70 YearsBoth62Phase 1United States;Canada
949NCT00634933
(ClinicalTrials.gov)
March 20085/3/2008Study Evaluating 2 Dosing Regimens Of TRU-015 In Rheumatoid ArthritisA Randomized, Parallel, Double-Blind, Placebo-Controlled Dose Regimen Finding Study To Evaluate The Safety And Efficacy Of TRU-015 In Subjects With Active Seropositive Rheumatoid Arthritis On A Stable Background Of MethotrexateArthritis, RheumatoidDrug: TRU-015;Drug: Methylprednisolone;Drug: PrednisonePfizerTrubion Pharmaceuticals/Emergent BioSolutions Inc.Terminated18 YearsN/AAll222Phase 2United States;Belgium;Canada;France;Germany;Hungary;Mexico;Netherlands;Romania;Serbia;Austria
950NCT00620685
(ClinicalTrials.gov)
March 200810/1/2008A Study To Evaluate The Safety And Pharmacokinetic Profile Of A P38 Inhibitor (PH-797804) In Subjects With Rheumatoid Arthritis Who Are Also Taking MethotrexateA 4-Week, Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study To Evaluate The Safety And Pharmacokinetic Profile Of 1 And 5 Mg Ph-797804 Administered Once Daily In Subjects With Rheumatoid Arthritis Who Are Taking Oral MethotrexateArthritis, RheumatoidDrug: Placebo;Drug: PH-797804PfizerNULLCompleted18 YearsN/AAll27Phase 2United States
951NCT00565409
(ClinicalTrials.gov)
March 200828/11/2007Study Comparing Etanercept in Combination With Methotrexate in Subjects With Rheumatoid ArthritisA Randomized, Double-Blind Study Comparing the Safety & Efficacy of Once-Weekly Etanercept 50 mg, Etanercept 25 mg, & Placebo in Combination With Methotrexate in Subjects With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: Etanercept;Drug: Methotrexate;Drug: PlaceboPfizerNULLCompleted18 Years70 YearsAll834Phase 4Australia;Austria;Belgium;Chile;Colombia;Czech Republic;Former Serbia and Montenegro;France;Germany;Hungary;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Russian Federation;Spain;Sweden;Taiwan;United Kingdom;Brazil;Korea, Democratic People's Republic of;Serbia
952NCT00556894
(ClinicalTrials.gov)
February 20088/11/2007Oral CF101 Tablets and Methotrexate Treatment in Rheumatoid Arthritis PatientsA Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study of the Safety and Efficacy of Daily CF101 Administered Orally, When Added to Weekly Methotrexate, in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CF101;Drug: PlaceboCan-Fite BioPharmaNULLCompleted18 Years75 YearsAll253Phase 2Bulgaria;Czechia;Israel;Poland;Serbia;Ukraine;Czech Republic;Former Serbia and Montenegro
953NCT01017367
(ClinicalTrials.gov)
February 200816/11/2009Study of MDX-1100 (Anti-CXCL10 Human Monoclonal Antibody) in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (RA)Phase 2, Multi-dose, Double-blind, Placebo-controlled, Randomized, Multicenter Study of MDX-1100 (Anti-CXCL10 Human Monoclonal Antibody) in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: MDX-1100;Drug: PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/ABoth70Phase 2Romania;Ukraine
954NCT01072058
(ClinicalTrials.gov)
February 200818/2/2010Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF BlockerProspective Evaluation of Heart Function by Echocardiographic Study, Pro-brain Natriuretic Peptide Type B and Troponin T in Patients With Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF BlockerArthritis, Rheumatoid;Spondylitis, AnkylosingDrug: TNF blockers (infliximab, adalimumab, etanercept)University of Sao PauloNULLActive, not recruiting18 Years70 YearsBoth100Phase 4Brazil
955NCT00611455
(ClinicalTrials.gov)
January 1, 200816/1/2008Investigating Clinical Efficacy of Ofatumumab in Adult Rheumatoid Arthritis (RA) Patients Who Had an Inadequate Response to MTX TherapyA Double-blind, Randomized, Placebo Controlled, Parallel Group, Multi-center, Phase III Trial of Ofatumumab Investigating Clinical Efficacy in Adult Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate TherapyArthritis, RheumatoidDrug: ofatumumab;Drug: PlaceboGlaxoSmithKlineNULLTerminated18 YearsN/AAll265Phase 3Argentina;Australia;Belgium;Chile;Czechia;Hungary;Peru;Poland;Romania;Russian Federation;South Africa;Spain;United Kingdom;Czech Republic
956NCT00655824
(ClinicalTrials.gov)
January 1, 20084/4/2008Long-term Efficacy and Safety of Repeated Ofatumumab Treatment Courses in RA Patients Who Previously Received Ofatumumab or Placebo in Trial Hx-CD20-403An Open-label, International, Multi-center, Phase II, Extension Trial Investigating Long-term Efficacy and Safety of Repeated Treatment Courses of Ofatumumab, a Fully Human Monoclonal Anti-CD20 Antibody, in Adult Patients With Active Rheumatoid Arthritis Who Previously Received Ofatumumab or PlaceboArthritis, RheumatoidDrug: ofatumumabGlaxoSmithKlineNULLTerminated18 YearsN/AAll124Phase 2United States;Denmark;Hungary;Poland;United Kingdom
957NCT00603525
(ClinicalTrials.gov)
January 200816/1/2008Investigating Clinical Efficacy of Ofatumumab in Adult Rheumatoid Arthritis (RA) Patients Who Had an Inadequate Response to TNF-a Antagonist TherapyA Double-blind, Randomized, Placebo Controlled, Parallel Group, Multi-center, Phase III Trial of Ofatumumab Investigating Clinical Efficacy in Patients With Active Rheumatoid Arthritis Who Have Previously Had an Inadequate Response to One or More TNF Antagonist TherapiesArthritis, RheumatoidDrug: Ofatumumab;Drug: PlaceboGlaxoSmithKlineNULLTerminated18 YearsN/AAll169Phase 3Argentina;Denmark;France;Germany;Italy;Korea, Republic of;Netherlands;Norway;Peru;Spain;Sweden;United Kingdom
958NCT00603512
(ClinicalTrials.gov)
January 200817/1/2008Comparison Of 4 CP-690,550 Doses Vs. Placebo, Each Combined With Methotrexate, For The Treatment Of Rheumatoid Arthritis in JapanA Phase 2, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Confirm Dose Responsiveness Following 12 Weeks of the Administration of CP-690,550 (4 Doses) or Placebo in Subjects With Active Rheumatoid Arthritis Inadequately Controlled With Methotrexate AloneArthritis, RheumatoidDrug: Placebo;Drug: CP-690,550PfizerNULLCompleted20 Years70 YearsAll140Phase 2Japan
959NCT00559585
(ClinicalTrials.gov)
January 200815/11/2007Methotrexate-Inadequate Response StudyA Phase IIIB Multicenter, Randomized, Double-Blind, Double-Dummy Study to Compare the Efficacy and Safety of Abatacept Administered Subcutaneously and Intravenously in Subjects With Rheumatoid Arthritis, Receiving Background Methotrexate, and Experiencing an Inadequate Response to MethotrexateRheumatoid Arthritis (RA)Drug: Subcutaneous (SC) Abatacept;Drug: Intravenous (IV) AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll2492Phase 3United States;Argentina;Australia;Belgium;Brazil;Canada;Chile;France;Germany;Greece;Hungary;India;Ireland;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Poland;Russian Federation;South Africa;Taiwan;Turkey;United Kingdom;Austria;Spain
960NCT00741104
(ClinicalTrials.gov)
January 200830/7/2008A Feasibility Study Exploring the Effect of Remicade on the Disease Activity in RA Patients (Study P05417)A Feasibility Study Exploring the Effect of Remicade on the Disease Activity in RA PatientsRheumatoid ArthritisDrug: InfliximabMerck Sharp & Dohme Corp.NULLCompletedN/AN/AAll363NULL
961NCT01362153
(ClinicalTrials.gov)
December 26, 200710/3/2011A Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Golimumab in Patients With Rheumatoid Arthritis (RA)An Open-label Randomized Phase 1 Study to Investigate the Pharmacokinetics and Pharmacodynamics of Subcutaneous and Intravenous Administrations of Golimumab to Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: GolimumabCentocor, Inc.NULLCompleted18 Years99 YearsAll49Phase 1United States
962NCT00576433
(ClinicalTrials.gov)
December 200718/12/2007A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF Inhibitor.An Open Label Study to Evaluate the Safety and Effect on Treatment Response of MabThera in Patients With Rheumatoid Arthritis Following Inadequate Response to One Prior Anti-TNF InhibitorRheumatoid ArthritisDrug: Methotrexate;Drug: rituximab [MabThera/Rituxan]Hoffmann-La RocheNULLCompleted18 Years80 YearsBoth60Phase 4Russian Federation
963NCT00580840
(ClinicalTrials.gov)
December 200721/12/2007Dosing Flexibility Study in Patients With Rheumatoid ArthritisA Phase IIIb Open-label run-in Double-blind, Placebo Controlled, Randomized Study to Evaluate the Safety/Efficacy of Certolizumab Pegol Administered Concomitantly With Stable-dose Methotrexate in Patients With Active Rheumatoid Arthritis.Rheumatoid ArthritisDrug: Certolizumab pegol;Other: PlaceboUCB PharmaNULLCompleted18 YearsN/AAll333Phase 4United States;Canada;France;Austria
964NCT00547521
(ClinicalTrials.gov)
December 200719/10/2007Phase IIIB Subcutaneous Abatacept Monotherapy StudyA Phase IIIb, Multi-center, Stratified, Open-Label Study to Evaluate the Immunogenicity, Steady State Trough Level, and Safety of Subcutaneous Abatacept (BMS-188667) in Subjects With Rheumatoid Arthritis Administered With or Without Background MethotrexateRheumatoid Arthritis (RA)Drug: abatacept;Drug: Methotrexate (MTX)Bristol-Myers SquibbNULLCompleted18 YearsN/AAll119Phase 3United States;Australia;Mexico;South Africa;Brazil;Canada;Peru
965NCT00647270
(ClinicalTrials.gov)
December 200727/3/2008Study Comparing 80 mg of Adalimumab With Placebo, and Demonstrating the Non-inferiority of Monthly 80 mg Adalimumab Dosing Compared With 40 mg Adalimumab Every Other Week DosingA Multi-center, Randomized, Double-blind,Placebo-controlled Study Comparing 80 mg of Adalimumab With Placebo, and Demonstrating the Non-inferiority of Monthly 80 mg Adalimumab Dosing Compared With 40 mg Adalimumab Every Other Week DosingRheumatoid ArthritisDrug: adalimumab;Drug: PlaceboAbbottNULLCompleted18 YearsN/AAll420Phase 3United States;Australia;Canada;Germany;Puerto Rico;United Kingdom
966NCT00576706
(ClinicalTrials.gov)
December 200717/12/2007PReventive Efficacy and Safety of rEbamipide on Nsaid Induced Mucosal ToxicityA Phase III, Randomized, Double-dummy, Double Blind, Misoprostol-comparative Clinical Trial to Evaluate the Efficacy and Safety of Mucosta® Tablet in the Prevention of NSAID-induced Gastrointestinal ComplicationsRheumatoid Arthritis;Osteoarthritis;Ankylosing SpondylitisDrug: Rebamipide;Drug: MisoprostolKorea Otsuka Pharmaceutical Co.,Ltd.NULLCompleted19 YearsN/ABoth396Phase 3Korea, Republic of
967NCT01231321
(ClinicalTrials.gov)
December 200728/10/2010A Study of Adalimumab When Added to Inadequate Standard Anti-rheumatic Therapy in Patients With Active Rheumatoid ArthritisAn Open-label, Prospective, Multi-Centre Study to Assess the Safety and Efficacy of Adalimumab (Humira®) When Added to Inadequate Standard Anti-Rheumatic Therapy in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: adalimumabAbbottNULLCompleted18 YearsN/AAll100Phase 3Russian Federation
968NCT00580229
(ClinicalTrials.gov)
December 200718/12/2007A Safety Analysis of Oral Prednisone as a Pre-Treatment for Rituximab in Rheumatoid Arthritis.A Safety Analysis of Oral Prednisone as a Pre-Treatment for Rituximab in Rheumatoid Arthritis.Rheumatoid ArthritisDrug: prednisoneUniversity of South FloridaNULLCompleted18 Years80 YearsAll50Phase 2/Phase 3United States
969NCT00963703
(ClinicalTrials.gov)
December 200720/8/2009Treatment of TNFa Naive Patients With Poor Prognosis Rheumatoid ArthritisTreatment of TNFa Naive Patients With Poor Prognosis Rheumatoid Arthritis Using Rituximab: A Pilot Study Evaluating Synovial OutcomesRheumatoid ArthritisDrug: RituximabUniversity of ManitobaHoffmann-La RocheCompleted18 YearsN/ABoth15N/ACanada
970NCT00596206
(ClinicalTrials.gov)
December 20074/1/2008Leflunomide EfficAcy Response Related to Dosing Regimen in Early Rheumatoid ArthritisAssessment of the Early Efficacy Response Rate of Leflunomide According to the Initial Dosing Regimen in the Treatment of Naive-DMARD (Disease Modifying Anti-Rheumatic Drug) Early RA (Rheumatoid Arthritis)-PatientsArthritis, RheumatoidDrug: leflunomideSanofiNULLCompleted18 YearsN/ABoth124Phase 3Czech Republic;Italy;Korea, Republic of;Portugal;Romania
971NCT00302952
(ClinicalTrials.gov)
November 6, 200713/3/2006Lovastatin for the Treatment of Mildly Active Rheumatoid ArthritisA Double Blind, Placebo Controlled, Phase II, Randomized Study of Lovastatin Therapy in the Treatment of Mildly Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Lovastatin;Drug: PlaceboNational Institute of Allergy and Infectious Diseases (NIAID)Autoimmunity Centers of ExcellenceTerminated18 Years70 YearsAll64Phase 2United States
972NCT00554853
(ClinicalTrials.gov)
November 20076/11/2007PPAR-gamma Agonists, Rheumatoid Arthritis and Cardiovascular DiseasePeroxisome Proliferator-activated Receptor-gamma Agonists, Rheumatoid Arthritis and Cardiovascular DiseaseRheumatoid ArthritisDrug: pioglitazone;Drug: Sublingual nitroglycerineUniversity of MichiganNational Heart, Lung, and Blood Institute (NHLBI)Completed21 Years100 YearsAll143Phase 3United States
973NCT01245361
(ClinicalTrials.gov)
November 200719/11/2010A 6-Months Infliximab Or Placebo Study In UA At High Risk Of RA:Clinical,Radiological And Synovial BenefitA Comparative Study Of A 6-Month Infliximab (Remicade®) Or Placebo Regimen In Undifferentiated Arthritis At High Risk For The Development Of Rheumatoid Arthritis (RA) : Clinical, Radiological (MRI) And Synovial Benefit P1200/001.Undifferentiated ArthritisDrug: Infliximab;Drug: sodium chloridePatrick DurezNULLCompletedN/AN/ABoth30N/ABelgium
974NCT00533897
(ClinicalTrials.gov)
November 200720/9/2007Phase IIIB Subcutaneous Missed Dose StudyA Phase IIIb, Multi-Center, Randomized, Withdrawal Study to Evaluate the Immunogenicity and Safety of Subcutaneous Administered Abatacept in Adults With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Abatacept;Drug: PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/AAll270Phase 3United States;Argentina;Canada;Mexico;South Africa;Brazil
975NCT00535782
(ClinicalTrials.gov)
October 31, 200724/9/2007A Study of the Effect of Tocilizumab on Markers of Atherogenic Risk in Patients With Moderate to Severe Rheumatoid ArthritisA Mechanism of Action Study to Evaluate the Effects of IL-6 Receptor Blockade With Tocilizumab (TCZ) on Lipids, Arterial Stiffness, and Markers of Atherogenic Risk in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA).Rheumatoid ArthritisDrug: Tocilizumab;Drug: Placebo;Drug: MethotrexateHoffmann-La RocheNULLCompleted18 Years75 YearsAll132Phase 3United States;Canada;Puerto Rico;United Kingdom
976NCT00502853
(ClinicalTrials.gov)
October 25, 200717/7/2007A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis.Pilot Study to Evaluate the Effect of Mabthera in Combination With MTX in the Inhibition of Progression of Synovitis, Bone Marrow Edema, and Erosions Evaluated by Magnetic Resonance Imaging (MRI) in the Hand of Patients With Rheumatoid Arthritis.Rheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: MethotrexateHoffmann-La RocheNULLCompleted18 Years75 YearsAll10Phase 4Italy
977NCT00525213
(ClinicalTrials.gov)
October 20074/9/2007Study to Evaluate the Efficacy and Safety of Orally Administered Rob 803 When Added to MethotrexateA Phase II, Randomised, Double-blind, International, Multicentre, Placebo-controlled, Dose-ranging, Parallel-group Study to Evaluate the Efficacy and Safety of Orally Administered Rob 803 When Added to Stable MethotrexateRheumatoid ArthritisDrug: Rob 803;Drug: PlaceboOxyPharmaNULLCompleted18 YearsN/ABoth224Phase 2Belgium;Bulgaria;Georgia;Latvia;Lithuania;Poland;Romania;Serbia;Sweden;United Kingdom;Former Serbia and Montenegro
978NCT00545454
(ClinicalTrials.gov)
October 200716/10/2007Activity and Safety of Oral Administration of SSR150106XB for the Reduction of Inflammation in Patients With Active Rheumatoid ArthritisActivity and Safety of Oral Administration of SSR150106XB for the Reduction of Inflammation in Patients With Active Rheumatoid Arthritis (RA): A 4-week, Multicenter, Randomized, Double-blind, Placebo-controlled Parallel Group Study of 90 µg Administered Once Daily and 90 µg Once Every Other DayRheumatoid ArthritisDrug: SSR150106;Drug: PlacebosSanofiNULLCompleted18 Years75 YearsAll79Phase 2Bulgaria;Croatia;Czechia;Romania;Russian Federation;Slovakia;Ukraine;Czech Republic;Former Serbia and Montenegro
979NCT00531817
(ClinicalTrials.gov)
October 200718/9/2007A Study of Tocilizumab in Combination With DMARDs in Patients With Moderate to Severe Rheumatoid ArthritisA Randomized, Double-blind, Parallel-group Study to Evaluate the Safety and Efficacy of Tocilizumab (TCZ) Versus Placebo in Combination With Disease Modifying Antirheumatic Drugs (DMARDs) in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Tocilizumab;Drug: Placebo;Drug: Permitted DMARDsHoffmann-La RocheNULLCompleted18 YearsN/AAll619Phase 3United States;Puerto Rico
980NCT00550043
(ClinicalTrials.gov)
October 200724/10/2007A Study Exploring the Safety, Tolerability and Efficacy of a 4 Week Course of INCB018424 in Subjects With Active Rheumatoid ArthritisA Double-blind, Placebo-controlled Study Exploring the Safety, Tolerability and Efficacy of a 4 Week Course of INCB018424 in Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: INCB018424;Drug: PlaceboIncyte CorporationNULLCompleted18 Years70 YearsAll50Phase 2United States;Poland
981NCT02699892
(ClinicalTrials.gov)
October 200725/2/2016Study to Examine Efficacy and Safety of Rituximab in Participants With Rheumatoid ArthritisPost Marketing Non Interventional Clinical Research of Administration of Rituximab in Rheumatoid ArthritisRheumatoid ArthritisDrug: RituximabHoffmann-La RocheNULLCompleted18 Years80 YearsAll130N/ASerbia
982NCT00934648
(ClinicalTrials.gov)
October 20076/7/2009A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to MethotrexateAn Open Label Study to Evaluate the Safety and Efficacy of Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Prior Treatment With MethotrexateRheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: methotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll15Phase 4Morocco
983NCT00595517
(ClinicalTrials.gov)
October 20077/1/2008Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced UlcerA Long Term Study to Investigate the Efficacy and Safety Study of D961H (Esomeprazole) (20 mg Once Daily) for the Prevention of Gastric and/or Duodenal Ulcers Associated With Daily Nonsteroidal Anti-inflammatory Drug (NSAID) UseGastric Ulcer;Duodenal Ulcer;Rheumatoid Arthritis;Osteoarthritis;LumbagoDrug: Esomeprazole 20 mgAstraZenecaNULLCompleted20 YearsN/AAll395Phase 3Japan
984NCT00626275
(ClinicalTrials.gov)
October 200722/2/2008Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Participants With Rheumatoid ArthritisA Phase 2a Randomized, Placebo- and Active-Controlled, Single-Dose, 3-Period, Crossover Study Followed by a Randomized, Placebo-Controlled, 14-Day, Parallel-Group Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: ADL5859;Drug: Naproxen;Drug: PlaceboCubist Pharmaceuticals LLCNULLCompleted18 Years75 YearsAll46Phase 2United States
985NCT00551707
(ClinicalTrials.gov)
October 200729/10/2007Multicenter Study to Evaluate CRx-102 vs. Each of Its Components to Treat Active Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Superiority of CRx-102 Over Each of Its Components When Given to Subjects With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: CRx-102 (2.7/180);Drug: prednisolone;Drug: dipyridamole;Drug: placebo;Drug: CRx-102 (2.7/360)ZalicusNULLCompleted18 YearsN/AAll51Phase 2United States;Argentina;Canada;Estonia;Hungary;Lithuania;Mexico;Poland;Romania;Russian Federation;Serbia;South Africa
986NCT00554606
(ClinicalTrials.gov)
October 20075/11/2007Long-term Efficacy, Safety and Tolerability of ACZ885 in Patients With Rheumatoid ArthritisA 54-week, Phase II, Multi-center, Open-label Extension Study to Evaluate the Efficacy, Safety and Tolerability of ACZ885 (Anti-interleukin-1B Monoclonal Antibody) in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: ACZ885NovartisNULLCompleted18 Years75 YearsAll115Phase 2United States;Belgium;Germany;Italy;Netherlands;Russian Federation;Spain;Switzerland;Turkey
987NCT00539760
(ClinicalTrials.gov)
September 5, 20074/10/2007A Phase I Rheumatoid Arthritis Study in Healthy VolunteersA Phase I, Randomized, Observer- and Subject-Blind, Placebo-Controlled, Single Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK1827771 in Healthy VolunteersArthritis, RheumatoidDrug: GSK1827771;Drug: PlaceboGlaxoSmithKlineNULLCompleted18 Years55 YearsAll45Phase 1United States
988NCT00411424
(ClinicalTrials.gov)
September 200712/12/2006Safety, Tolerability and Efficacy Study of the New Medication ASK8007 to Treat Patients With Rheumatoid ArthritisSafety, Tolerability, Pharmacokinetics, Pharmacodynamics and Initial Efficacy of ASK8007 in Comparison With Placebo in Patients With Active Rheumatoid Arthritis - a Randomized, Double Blind, Placebo-controlled, Combined Single Dose Escalation and Multiple Dose StudyRheumatoid ArthritisDrug: ASK8007;Drug: PlaceboAstellas Pharma IncNULLCompleted18 YearsN/ABoth54Phase 1/Phase 2Belgium;Hungary;Ireland;Netherlands;Spain;United Kingdom;France
989NCT00660647
(ClinicalTrials.gov)
September 200710/4/2008Optimized Treatment Algorithm for Patients With Early Rheumatoid Arthritis (RA)Optimized Treatment Algorithm in Early Rheumatoid Arthritis: Methotrexate and Intra-articular Glucocorticosteroid Plus Adalimumab or Placebo in the Treatment of Early Rheumatoid ArthritisArthritis, RheumatoidDrug: Adalimumab;Drug: PlaceboUniversity of AarhusAbbott;Meda Pharmaceuticals;Aarhus University HospitalCompleted18 YearsN/ABoth180Phase 3Denmark
990NCT00595413
(ClinicalTrials.gov)
September 20077/1/2008Atacicept in Anti-Tumor Necrosis Factor Alpha-naïve Subjects With Rheumatoid Arthritis (AUGUST II)A Randomised, Double-blind, Placebo Controlled, Multi-centre Phase II Study of Atacicept in Anti-TNFa-naïve Patients With Moderate to Severely Active Rheumatoid Arthritis and an Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Placebo matched to atacicept;Drug: Atacicept: with loading dose;Drug: Atacicept;Biological: AdalimumabEMD SeronoMerck KGaACompleted18 YearsN/AAll311Phase 2United States;Germany
991NCT00613106
(ClinicalTrials.gov)
September 200728/1/2008Double-Blind Follow-on Safety Study of HZT-501 (Ibuprofen 800 mg/Famotidine 26.6 mg) in Subjects Who Have Completed Participation in HZ-CA-301 (NCT00450658) or HZ-CA-303 (NCT00450216)Double-Blind Follow-On Safety Study of HZT-501 (Ibuprofen 800 mg/Famotidine 26.6 mg)in Subjects Who Have Completed Participation in Horizon Protocol HZ-CA-301 (NCT00450658)or Horizon Protocol HZ-CA-303 (NCT00450216)Osteoarthritis;Rheumatoid Arthritis;Chronic Low Back Pain;Chronic Regional Pain Syndrome;Chronic Soft Tissue PainDrug: HZT-501;Drug: IbuprofenHorizon Pharma Ireland, Ltd., Dublin IrelandNULLCompleted40 Years81 YearsAll179Phase 3United States
992NCT00523692
(ClinicalTrials.gov)
September 200730/8/2007Remission Induction in Very Early Rheumatoid ArthritisRemission Induction in Very Early Rheumatoid Arthritis: a Comparison of Etanercept Plus Methotrexate Plus Steroid With Standard TherapyRheumatoid ArthritisDrug: Etanercept, methotrexate and depomedrone;Drug: depemedroneUniversity Hospital BirminghamWyeth is now a wholly owned subsidiary of PfizerNot yet recruiting18 YearsN/ABoth20Phase 4United Kingdom
993NCT00550446
(ClinicalTrials.gov)
September 200725/10/2007A Phase 2 Study For Patients With A Physician's Diagnosis Of Rheumatoid ArthritisA Phase 2b, Randomized, Double Blind, Placebo Controlled Active Comparator, Multicenter Study To Compare 5 Dose Regimens Of CP- 690,550 And Adalimumab Versus Placebo, Administered For 6 Months In The Treatment Of Subjects With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: Adalimumab;Drug: CP-690-550;Drug: CP-690,550;Drug: PlaceboPfizerNULLCompleted18 YearsN/AAll386Phase 2United States;Brazil;Bulgaria;Chile;Croatia;Czech Republic;Germany;Greece;Hungary;Italy;Korea, Republic of;Mexico;Romania;Slovakia;Ukraine
994NCT03414502
(ClinicalTrials.gov)
August 20072/1/2014Treatment of Rheumatoid Arthritis With DMARDs: Predictors of ResponseTreatment of Rheumatoid Arthritis With DMARDs: Predictors of ResponseRheumatoid ArthritisDrug: Methotrexate;Drug: Abatacept;Drug: Adalimumab;Drug: Azathioprine;Drug: Baricitinib;Drug: Certolizumab;Drug: Etanercept;Drug: Golimumab;Drug: Hydroxychloroquine;Drug: Infliximab;Drug: Leflunomide;Drug: Minocycline;Drug: Rituximab;Drug: Sarilumab;Drug: Sulfasalazine;Drug: TofacitinibUniversity of NebraskaNULLRecruiting19 YearsN/AAll400Phase 3United States
995NCT00760968
(ClinicalTrials.gov)
August 200724/9/2008Efficacy and Safety of TAK-783 in Subjects With Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled Proof of Concept Study to Evaluate the Safety and Efficacy of Oral TAK-783 in the Treatment of the Signs and Symptoms in Subjects With Rheumatoid ArthritisArthritis, RheumatoidDrug: TAK-783 and methotrexate;Drug: MethotrexateTakedaNULLCompleted18 YearsN/ABoth224Phase 2Czech Republic;Latvia;Romania;Russian Federation;Slovakia;Ukraine
996NCT00550355
(ClinicalTrials.gov)
August 200725/10/2007Dose-Escalating Multiple Dose Study of PD-0360324 in Combination With Methotrexate in Patients With Rheumatoid ArthritisA Randomized, Subject and Investigator-Blind, Placebo-Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Intravenously Administered Doses of PD-0360324 in Patients With Rheumatoid Arthritis Receiving MethotrexateArthritis, RheumatoidDrug: PD 0360324;Drug: PlaceboPfizerNULLCompleted21 Years70 YearsBoth78Phase 1United States;Argentina;Bulgaria;Czech Republic;Mexico;Poland;Slovakia;Spain
997NCT00517543
(ClinicalTrials.gov)
August 200716/8/2007A Study to Examine the Effect of Particle Size on Bioequivalence and BioavailabilityA Randomized, Open Label, 4 Period Crossover Study in Healthy Subjects to Determine the Effect of Particle Size on the Pharmacokinetics of a Single mg Dose of GW856553Chronic Obstructive Pulmonary Disease (COPD);Rheumatoid Arthritis;AtherosclerosisDrug: GW856553GlaxoSmithKlineNULLCompleted18 Years60 YearsBoth36Phase 1United States
998NCT00511329
(ClinicalTrials.gov)
August 20072/8/2007Growth Hormone in Children With Juvenile Rheumatoid Arthritis (JRA) and With Crohn's DiseaseGrowth and the Effect of Genotropin in Chronically Ill Children With Juvenile Rheumatoid Arthritis and With Crohn's DiseaseArthritis, Juvenile Rheumatoid;Crohn DiseaseDrug: somatropin [rDNA origin] for injectionNationwide Children's HospitalPfizerTerminated5 Years17 YearsAll10Phase 2/Phase 3United States
999NCT00505089
(ClinicalTrials.gov)
August 200719/7/2007Efficacy and Safety of Subcutaneous Versus Intravenous ACZ885 in Adult Patients With Established Rheumatoid ArthritisAn Exploratory, Open Label Pharmacokinetic - Pharmacodynamic Study to Compare Subcutaneous Versus Intravenous Administration of ACZ885 in Adult Patients With Established Rheumatoid ArthritisRheumatoid ArthritisDrug: ACZ885NovartisNULLTerminated18 Years75 YearsBoth11Phase 1/Phase 2Belgium;Germany;Netherlands;Poland
1000NCT00597818
(ClinicalTrials.gov)
August 200710/1/2008Cobiprostone Prevention of NSAID-induced Gastroduodenal InjuryA Multi-center, Randomized, Placebo-controlled, Double-blinded Study of the Efficacy and Safety of Cobiprostone for the Prevention of NSAID-induced Gastroduodenal Injury in Patients With Osteoarthritis and/or Rheumatoid Arthritis PatientsNSAID-induced Gastroduodenal Injury;Ulcers;Rheumatoid Arthritis;OsteoarthritisDrug: Cobiprostone;Drug: Placebo;Drug: Non-steroidal anti-inflammatory drugSucampo Pharma Americas, LLCNULLCompleted40 Years70 YearsAll121Phase 2United States
1001NCT00520572
(ClinicalTrials.gov)
August 200722/8/2007A 6-month Randomised, Double-blind, Open Arm Comparator, Phase IIb, With AZD9056, in Patients With Rheumatoid Arthritis (RA)A Randomised, Double-Blind (With Open Comparator Etanercept Limb), Placebo-Controlled, Phase IIb, Multicentre Study to Evaluate the Efficacy of 4 Doses of AZD9056 Administered for 6 Months on the Signs and Symptoms of Rheumatoid Arthritis in Patients With Active Disease Receiving Background Methotrexate or SulphasalazineRheumatoid ArthritisDrug: AZD9056;Drug: Etanercept;Drug: PlaceboAstraZenecaNULLCompleted18 YearsN/AAll385Phase 2United States;Argentina;Australia;Belgium;Canada;Czech Republic;France;Mexico;Poland;Romania;Russian Federation;Slovakia;Hungary;Sweden
1002NCT00523328
(ClinicalTrials.gov)
August 200717/8/2007BG9924 in Combination With Methotrexate Extension of Study 104RA203An Open-Label Extension Study to Evaluate the Safety and Efficacy of BG9924 When Given in Combination With Methotrexate to Subjects With Rheumatoid Arthritis Who Previously Participated in Study 104RA203Rheumatoid ArthritisDrug: BG9924Biogen IdecNULLTerminated18 Years75 YearsBoth72Phase 2United States;Belgium;Canada;United Kingdom
1003NCT00542789
(ClinicalTrials.gov)
August 200711/10/2007Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAIDA Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Comparative Efficacy and Safety Study of Esomeprazole(20 mg Once Daily) Versus Placebo for the Prevention of Gastric and/or Duodenal Ulcers Associated With Daily Nonsteroidal Anti-inflammatory Drug (NSAID) UseGastric Ulcer;Duodenal Ulcer;Rheumatoid Arthritis;Osteoarthritis;LumbagoDrug: Esomeprazole;Drug: PlaceboAstraZenecaNULLCompleted20 YearsN/AAll343Phase 3Japan
1004NCT00502840
(ClinicalTrials.gov)
July 23, 200717/7/2007A Study of Re-Treatment With MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF Inhibitor.An Open Label Study to Evaluate the Safety of Re-treatment With MabThera, and Its Effect on Treatment Response, in Patients With Rheumatoid Arthritis Following Inadequate Response to a Single Anti-TNF Agent (Extension Study to ML19070).Rheumatoid ArthritisDrug: rituximab [MabThera/Rituxan]Hoffmann-La RocheNULLCompleted18 Years75 YearsAll193Phase 3Germany
1005NCT00504777
(ClinicalTrials.gov)
July 200719/7/2007A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Agents.An Open Label Study to Evaluate the Safety, and Effect on Treatment Response, of MabThera in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response or Intolerance to One or More Anti-TNF Agents.Rheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: MethotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll36Phase 4Taiwan
1006NCT00503139
(ClinicalTrials.gov)
July 200716/7/2007Study Evaluating the Safety and Efficacy of Enbrel (Etanercept) in JapanEnbrel Special Use Result SurveillanceRheumatoid ArthritisDrug: Enbrel (etanercept)PfizerNULLCompleted10 YearsN/AAll684Japan
1007NCT00555230
(ClinicalTrials.gov)
July 20077/11/2007Effects of HMG-coA Reductase Inhibitor on Rheumatoid ArthritisEffects of HMG-coA Reductase Inhibitor on Progression of Carotid Intima-Media Thickness and Arterial Stiffness in Rheumatoid ArthritisRheumatoid ArthritisDrug: Rosuvastatin;Drug: PlaceboChinese University of Hong KongNULLCompleted18 Years75 YearsBoth150Phase 2China
1008NCT00405275
(ClinicalTrials.gov)
July 200729/11/2006Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate TherapyCSP #551 - Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate TherapyRheumatoid ArthritisDrug: Etanercept;Drug: methotrexate;Drug: Sulfasalazine;Drug: Hydroxychloroquine;Drug: Placebo, triple;Drug: Placebo, etanerceptVA Office of Research and DevelopmentCanadian Institutes of Health Research (CIHR);Rheumatoid Arthritis Investigational Network (RAIN);National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed18 YearsN/AAll353N/AUnited States;Canada
1009NCT00485589
(ClinicalTrials.gov)
June 11, 200711/6/2007A Study of Ocrelizumab in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Are Naive to Methotrexate (FILM)A Randomized, Double-Blind, Parallel Group, International Study to Evaluate the Safety and Efficacy of Ocrelizumab in Combination With Methotrexate (MTX) Compared to MTX Alone in Methotrexate- Naive Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Methotrexate;Drug: Ocrelizumab;Drug: PlaceboGenentech, Inc.Roche Pharma AGTerminated18 YearsN/AAll613Phase 3United States
1010NCT00896168
(ClinicalTrials.gov)
June 20077/5/2009An Efficacy and Safety Study of Infliximab in Participants With Rheumatoid ArthritisA Multi-Center, Pre-Marketing Clinical Trial to Evaluate the Efficacy and Safety of Infliximab Treatment on Rheumatoid ArthritisArthritis, RheumatoidDrug: Infliximab;Drug: MethotrexateXian-Janssen Pharmaceutical Ltd.NULLCompleted18 Years65 YearsAll234Phase 4NULL
1011NCT00447759
(ClinicalTrials.gov)
June 200714/3/2007The Standard Care Versus Celecoxib Outcome TrialPhase 4 Study A Large Streamline Safety Study Designed to Compare the Cardiovascular Safety od Celecoxib Versus Traditional Non-selective NSAID'sOsteoarthritis;Rheumatoid ArthritisDrug: Celecoxib;Drug: DiclofenacUniversity of DundeeUniversity of Glasgow;University of NottinghamCompleted60 YearsN/AAll7297Phase 4Denmark;Netherlands;United Kingdom
1012NCT00422227
(ClinicalTrials.gov)
June 200711/1/2007Study Comparing Etanercept With Usual DMARD Therapy in Subjects With Rheumatoid Arthritis in the Asia Pacific RegionA Randomized, Open-Label Study in the Asia-Pacific Region Comparing the Safety and Efficacy of Etanercept With Usual DMARD Therapy in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: Etanercept , Methotrexate;Drug: Methotrexate; sulfasalazine; hydroxychloroquine;leflunomideWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 Years70 YearsAll300Phase 4Hong Kong;India;Korea, Republic of;Malaysia;Philippines;Singapore;Taiwan;Thailand
1013NCT00462345
(ClinicalTrials.gov)
June 200718/4/2007A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies.An Open-label Study to Evaluate the Effect of MabThera in Combination With Methotrexate on Treatment Response in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF TherapiesRheumatoid ArthritisDrug: rituximab;Drug: Methotrexate;Drug: Corticosteroid or NSAID;Dietary Supplement: FolateHoffmann-La RocheNULLCompleted18 Years80 YearsAll40Phase 4Korea, Republic of
1014NCT00476996
(ClinicalTrials.gov)
May 15, 200718/5/2007A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Who Don't Have a Response to Anti-TNF-a Therapy (SCRIPT)A Randomized, Double-Blind, Parallel Group, International Study to Evaluate the Safety and Efficacy of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to at Least One Anti-TNF-a TherapyRheumatoid ArthritisDrug: Leflunomide;Drug: Methotrexate;Drug: Ocrelizumab;Drug: PlaceboGenentech, Inc.Roche Pharma AGTerminated18 YearsN/AAll836Phase 3United States;Argentina;Australia;Belgium;Brazil;Canada;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Mexico;Netherlands;New Zealand;Panama;Peru;Poland;Slovakia;Slovenia;Spain;Sweden;Switzerland;Taiwan
1015NCT00455208
(ClinicalTrials.gov)
May 200730/3/2007A Study Evaluating the Safety and Efficacy of Cura-100 in Subjects With Rheumatoid Arthritis and OsteoarthritisStudy Evaluating Cura-100 in Rheumatoid Arthritis and OsteoarthritisRheumatoid Arthritis;OsteoarthritisDrug: Cura-100Cura Biotech LLCNULLNot yet recruiting20 Years50 YearsBoth20Phase 1/Phase 2United States
1016NCT00760669
(ClinicalTrials.gov)
May 200724/9/2008An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis ParticipantsPost Marketing Surveillance of Remicade in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis PatientsSpondylitis, Ankylosing;Arthritis, Rheumatoid;Psoriasis;Arthritis, PsoriaticDrug: Infliximab; observational study;Drug: MethotrexateJanssen Korea, Ltd., KoreaNULLCompletedN/AN/AAll1061Korea, Republic of
1017NCT00578565
(ClinicalTrials.gov)
May 200719/12/2007Rituximab in Rheumatoid Arthritis Lung DiseaseRituximab for the Treatment of Rheumatoid Arthritis-Associated Interstitial Pneumonia: A Pilot StudyRheumatoid Arthritis;Interstitial PneumoniaDrug: RituximabEric MattesonGenentech, Inc.;National Center for Research Resources (NCRR)Completed18 Years80 YearsAll10Phase 3United States
1018NCT00420199
(ClinicalTrials.gov)
May 20078/1/2007A Phase IIIb Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis and Inadequate Response to MethotrexateA Phase IIIB Multicenter, Randomized, Double-Blind, Placebo-controlled Study to Assess Short-term Changes in Synovitis and Structural Damage Outcomes in Subjects With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate, Treated With Abatacept Versus Placebo on a Background Therapy With MethotrexateActive Rheumatoid ArthritisDrug: Abatacept;Drug: PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/AAll50Phase 3Belgium;Germany;Netherlands;Spain;Sweden;United Kingdom;Austria
1019NCT00504595
(ClinicalTrials.gov)
May 200719/7/2007Safety and Efficacy of ACZ885 in Adult Patients With Established Rheumatoid ArthritisA 12-week, Phase II, Multi-center, Randomized, Double-blind, Placebo-controlled Study to Assess the Response to Treatment (ACR20) and to Determine a Biomarker Profile in Adult Patients With Established Rheumatoid Arthritis Responding to ACZ885 (Anti-interleukin-1beta Monoclonal Antibody) as Compared to Healthy Subjects Exposed to ACZ885Rheumatoid ArthritisDrug: ACZ885 (investigational);Drug: PlaceboNovartisNULLCompleted18 Years75 YearsAll80Phase 2Russian Federation;Spain;Switzerland;Turkey
1020NCT00443430
(ClinicalTrials.gov)
May 20072/3/2007Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic ArthritisTrial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis (TREAT in JIA)Juvenile Chronic Polyarthritis;Juvenile Idiopathic Arthritis;Juvenile Rheumatoid ArthritisDrug: methotrexate;Drug: methotrexate - etanercept - prednisolone armSeattle Children's HospitalNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS);AmgenCompleted2 Years17 YearsAll85Phase 4United States
1021NCT00480272
(ClinicalTrials.gov)
May 200729/5/2007Prospective Study on Intensive Early Rheumatoid Arthritis TreatmentA Phase IV Multicenter, Randomized, Double-blind Study. prospeCtive Study on Intensive Early Rheumatoid Arthritis Treatment With adalimUmab: Induction of REmission and MaintenanceRheumatoid ArthritisDrug: adalimumab, plus prednisone;Drug: adalimumab plus placeboIRCCS Policlinico S. MatteoNULLCompleted18 Years70 YearsAll251Phase 4Italy
1022NCT00414661
(ClinicalTrials.gov)
April 200719/12/2006Long-Term Safety Follow-Up Of Subjects Previously Enrolled In Rheumatoid Arthritis Studies Of CP-690,550A Prospective Observational Study To Evaluate Long-Term Safety And Functional Status Of Subjects With Rheumatoid Arthritis Previously Enrolled In Studies Of CP-690,550Arthritis, RheumatoidDrug: CP-690,550PfizerNULLCompleted18 YearsN/AAll162N/AUnited States;Argentina;Brazil;Bulgaria;Canada;Chile;Czech Republic;Dominican Republic;Finland;Greece;Hungary;India;Italy;Japan;Korea, Republic of;Mexico;Poland;Puerto Rico;Slovakia;Spain;Ukraine;Australia;Austria;Belgium;Costa Rica;Romania;Sweden
1023NCT00446784
(ClinicalTrials.gov)
April 20079/3/2007Study Of The Safety Of CE 224,545 And Methotrexate In Patients With Rheumatoid ArthritisA Phase 1, Double Blind Study Of The Safety And Pharmacokinetics Of Multiple Doses Of CE 224,535 In Subjects With Rheumatoid Arthritis Receiving MethotrexateArthritis, RheumatoidDrug: CE-224,535;Drug: MethotrexatePfizerNULLCompleted18 YearsN/ABoth20Phase 1United States
1024NCT00409838
(ClinicalTrials.gov)
April 20078/12/2006A Phase III Study of Abatacept in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateA Phase III, Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Abatacept Administered Intravenously in Korean Subjects With Active Rheumatoid Arthritis While Receiving MethotrexateRheumatoid ArthritisDrug: Abatacept;Drug: Methotrexate;Drug: PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/AAll113Phase 3Korea, Republic of
1025NCT00484237
(ClinicalTrials.gov)
April 20077/6/2007A Study Evaluating 10 mg and 25 mg Doses of Etanercept in Patients With Rheumatoid ArthritisA Randomized, Double-Blind, Multicenter, Parallel Study Evaluating the Safety and Efficacy of Etanercept 10 mg Twice Weekly and 25 mg Once Weekly in Japanese Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: etanerceptWyeth is now a wholly owned subsidiary of PfizerNULLCompleted20 Years75 YearsBoth80Phase 3Japan
1026NCT00989235
(ClinicalTrials.gov)
April 20072/10/2009Substudy - Low Dose of Abatacept in Subjects With Rheumatoid ArthritisA Phase 3B, Multi-Center, Randomized, Double-blind Study to Evaluate Remission and Joint Damage Progression in Methotrexate-naïve Early Erosive Rheumatoid Arthritis Subjects Treated With Abatacept Plus Methotrexate Compared With Methotrexate - Low Dose Sub-StudyRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll108Phase 3NULL
1027NCT04144101
(ClinicalTrials.gov)
March 1, 200728/10/2019Etoricoxib vs Aceclofenac in the Treatment of Patients With Rheumatoid ArthritisComparison of Lower Dosage of Etoricoxib Versus Aceclofenac in the Treatment of Patients With Rheumatoid Arthritis: A Single-center, Parallel-group, Randomized Controlled Pilot StudyRheumatoid ArthritisDrug: Etoricoxib;Drug: AceclofenacChung Shan Medical UniversityNULLCompleted20 Years80 YearsAll40Phase 4NULL
1028NCT00458861
(ClinicalTrials.gov)
March 200722/3/2007BG9924 in Combination With Methotrexate for Subjects With Active Rheumatoid ArthritisA Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, PK, and PD of BG9924 When Given in Combo With MTX to Subjects With Active RA Who Have Had an Inadequate Response to Anti-TNFRheumatoid ArthritisDrug: BG9924;Other: Placebo ComparatorBiogen IdecNULLTerminated18 Years75 YearsBoth115Phase 2United States
1029NCT00462072
(ClinicalTrials.gov)
March 200717/4/2007Centocor Microarray Study of PatientsMicroarray Analysis of Peripheral Blood and Tissues of Patients With Immune Mediated Inflammatory DiseasesRheumatoid Arthritis;Psoriatic Arthritis;Psoriasis;Crohn's DiseaseDrug: InfliximabUniversity of RochesterCentocor, Inc.Completed12 YearsN/AAll31Phase 4United States
1030NCT00487825
(ClinicalTrials.gov)
March 200718/6/2007Safety and Efficacy of Intravenous ACZ885 and Oral Methotrexate Therapy in Patients With Early Rheumatoid ArthritisA 26-week, Phase II, Multi-center, Randomized, Double-blind, Placebo-controlled Study to Assess the Response to Treatment (ACR50) and to Determine a Biomarker Profile in Responders to ACZ885 (Anti-interleukin-1beta Monoclonal Antibody) Plus MTX as Compared to MTX Alone in Early Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: Canakinumab (investigational);Drug: Placebo;Drug: Methotrexate (MTX)NovartisNULLCompleted18 Years75 YearsAll78Phase 2United States;Belgium;Germany;Italy;Netherlands;Spain
1031NCT00913432
(ClinicalTrials.gov)
March 20073/6/2009Masitinib in Combination With Methotrexate, in Treatment of Patients With Active Rheumatoid ArthritisA 12-week With Possible Extension, Prospective, Multicenter, Randomized, Open Label, Uncontrolled, 2-parallel Group, Phase II Study to Compare Efficacy and Safety of AB1010 at 3 and 6 mg/kg/Day in Combination With Methotrexate, in Treatment of Patients With Active Rheumatoid Arthritis With Inadequate Response to 1. Methotrexate or to 2. Any DMARD Including Anti TNF Alpha if Patients Previously Failed Methotrexate or to 3. Methotrexate in Combination With Any DMARD Including Anti TNF AlphaRheumatoid ArthritisDrug: masitinibAB ScienceNULLCompleted18 YearsN/AAll20Phase 2NULL
1032NCT00413699
(ClinicalTrials.gov)
February 5, 200718/12/2006Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid ArthritisA Long-term, Open-label Follow-up Study Of Tofacitinib (Cp-690,550) For Treatment Of Rheumatoid ArthritisArthritis, RheumatoidDrug: CP-690,550PfizerNULLCompleted18 YearsN/AAll4488Phase 3United States;Argentina;Australia;Austria;Belgium;Bosnia and Herzegovina;Brazil;Bulgaria;Canada;Chile;China;Colombia;Costa Rica;Croatia;Czechia;Denmark;Dominican Republic;Finland;France;Germany;Greece;Hungary;India;Ireland;Italy;Korea, Republic of;Malaysia;Mexico;New Zealand;Peru;Philippines;Poland;Puerto Rico;Romania;Russian Federation;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;Czech Republic;United States Minor Outlying Islands
1033NCT00458146
(ClinicalTrials.gov)
February 20075/4/2007A Phase 2 Study to Evaluate the Efficacy and Safety of 60mg of MM-093 in Patients With Active Rheumatoid ArthritisA Phase 2, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of 60mg of MM-093 Versus Placebo in Patients With Active Rheumatoid Arthritis on Stable Doses of MethotrexateRheumatoid ArthritisDrug: MM-093Merrimack PharmaceuticalsNULLCompleted18 Years80 YearsBoth100Phase 2United States
1034NCT00427934
(ClinicalTrials.gov)
February 200725/1/2007Maraviroc in Rheumatoid ArthritisA Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Safety and Efficacy of Maraviroc in the Treatment of Rheumatoid Arthritis in Subjects Receiving MethotrexateArthritis, RheumatoidDrug: Maraviroc;Drug: Maraviroc PlaceboPfizerNULLTerminated18 YearsN/AAll128Phase 2United States;Australia;Germany;India;Italy;Mexico;Portugal;Spain;Ukraine
1035NCT00418717
(ClinicalTrials.gov)
February 20072/1/2007Open Label, Dose-Regimen Study Evaluating Etanercept 50 mg Once-Weekly In Japanese Subjects With RAAn Open-label, Multicenter, Dose-regimen Study Evaluating the Efficacy and Safety of Etanercept 50 mg Once-weekly Dose in Japanese Subjects With Rheumatoid ArthritisArthritis, RheumatoidDrug: etanerceptWyeth is now a wholly owned subsidiary of PfizerNULLCompleted20 Years75 YearsAll42Phase 3Japan
1036NCT00424502
(ClinicalTrials.gov)
January 200718/1/2007A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a TNF-Blocker.An Open-label Study to Evaluate the Effect of MabThera on Treatment Response in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Previous TNF Inhibition.Rheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: MethotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll20Phase 4Hungary
1037NCT00716248
(ClinicalTrials.gov)
January 20078/7/2008Bucillamine Study of Holding Remission After Infliximab Dose-offThe Bucillamine Study of Holding Remission After Infliximab Dose-off in Patients With Rheumatoid Arthritis Receiving MethotrexateRheumatoid ArthritisDrug: bucillamine;Drug: methotrexateSaitama Medical UniversityKeio UniversityActive, not recruiting20 YearsN/ABoth40Phase 4Japan
1038NCT00413660
(ClinicalTrials.gov)
January 200718/12/2006Comparison Of 6 CP-690,550 Doses Vs.Placebo, Each Combined With Methotrexate, For The Treatment Of Rheumatoid ArthritisA Phase 2B, Randomized, Double Blind, Placebo-Controlled, Multicenter Study To Compare 6 Dose Regimens Of CP-690,550 Vs. Placebo, Each Combined With Methotrexate, Administered For 6 Months In The Treatment Of Subjects With Active Rheumatoid Arthritis Who Have Had An Inadequate Response To Methotrexate AloneArthritis, RheumatoidDrug: CP-690,550;Other: placeboPfizerNULLCompleted18 YearsN/AAll509Phase 2United States;Argentina;Brazil;Bulgaria;Chile;Czech Republic;Hungary;Mexico;Poland;Slovakia;Spain;Sweden;Turkey
1039NCT02886689
(ClinicalTrials.gov)
January 200729/8/2016C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in FranceC.O.R.P.U.S. : Observational Cohort of Active Rheumatoid Arthritis, Spondylarthropathy and Idiopathic Juvenile Arthritis in FranceArthritis, Rheumatoid;Spondylitis, Ankylosing;Arthritis, Psoriatic;Arthitis, Juvenile IdiopathicDrug: TNF-alpha antagonist and other biotherapyCentral Hospital, Nancy, FranceNULLCompleted3 Years75 YearsBoth5400N/AFrance
1040NCT00443651
(ClinicalTrials.gov)
January 20072/3/2007A Study of the Safety of Rituximab in Combination With Other Anti-Rheumatic Drugs in Subjects With Active Rheumatoid ArthritisAn Open-Label, Prospective Study of the Safety of Rituximab in Combination With Other Disease-Modifying Anti-Rheumatic Drugs in Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Rituximab;Drug: Anti-inflammatory drugsGenentech, Inc.BiogenCompleted18 Years80 YearsAll578Phase 3United States
1041NCT00427804
(ClinicalTrials.gov)
January 200725/1/2007Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium AbsorptionTumor Necrosis Factor-a Induces Vitamin D Resistance in Small Intestinal Calcium AbsorptionRheumatoid Arthritis;Crohn's DiseaseDrug: calcitriolAtlanta VA Medical CenterEmory UniversityCompleted18 Years50 YearsMale9N/AUnited States
1042NCT00406419
(ClinicalTrials.gov)
December 27, 200630/11/2006A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Continuing Methotrexate Treatment (STAGE)A Randomized, Double-Blind, Parallel Group, International Study to Evaluate the Safety and Efficacy of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Continuing Methotrexate TreatmentRheumatoid ArthritisDrug: Methotrexate;Drug: ocrelizumab;Drug: PlaceboGenentech, Inc.Roche Pharma AGTerminated18 YearsN/AAll1015Phase 3United States
1043NCT00425321
(ClinicalTrials.gov)
December 200619/1/2007Safety and Effectiveness Study of RWJ-445380 Cathepsin-S Inhibitor in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyA Phase IIa Multicenter, Randomized, Double-Blind, Placebo -Controlled, Parallel Group Study of RWJ-445380 Cathepsin-S Inhibitor in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyRheumatoid ArthritisDrug: RWJ-445380 100 mg;Drug: RWJ-445380 200 mg;Drug: RWJ-445380 300 mg;Drug: PlaceboJohnson & Johnson Pharmaceutical Research & Development, L.L.C.NULLCompleted18 YearsN/ABoth259Phase 2United States;Argentina;Brazil;Czech Republic;Germany;Mexico;Poland
1044NCT00413452
(ClinicalTrials.gov)
December 200615/12/2006Etanercept SFP in RA PatientsOpen-Label Study to Assess the Safety and Immunogenicity of Etanercept SFP When Administered to Subjects Diagnosed With Rheumatoid Arthritis.Rheumatoid ArthritisDrug: EtanerceptAmgenWyeth is now a wholly owned subsidiary of PfizerCompleted18 YearsN/ABoth224Phase 3United States;Canada
1045NCT00420927
(ClinicalTrials.gov)
December 20069/1/2007Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid ArthritisA Multicenter, Randomized, Double-Period, Double - Blind Study to Determine the Optimal Protocol for Treatment Initiation With Methotrexate and Adalimumab Combination Therapy in Patients With Early Rheumatoid Arthritis (OPTIMA)Rheumatoid ArthritisDrug: methotrexate;Biological: placebo;Biological: adalimumabAbbottNULLCompleted18 YearsN/AAll1032Phase 4United States;Argentina;Australia;Austria;Belgium;Canada;Czech Republic;France;Germany;Hungary;Mexico;Netherlands;New Zealand;Norway;Poland;Puerto Rico;Slovakia;South Africa;Spain;Sweden;United Kingdom;Greece
1046NCT00383188
(ClinicalTrials.gov)
December 200628/9/2006An Oral p38 Inhibitor Investigating Safety, Efficacy, And PK In Subjects With Active Rheumatoid ArthritisA 12-Week, Phase 2A, Randomized, Double-Blind, Placebo-Controlled Study To Investigate The Safety, Pharmacokinetics, And Efficacy Of PH-797804, Administered Orally Once Daily In Subjects With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: placebo;Drug: PH-797804PfizerNULLCompleted18 YearsN/ABoth305Phase 2Australia;Brazil;Chile;Czech Republic;Estonia;India;Korea, Republic of;Peru;Poland;Russian Federation;South Africa;Spain
1047NCT00440492
(ClinicalTrials.gov)
December 200623/2/2007Study To Evaluate The Pharmacokinetic Interaction Between PLA-695 And Methotrexate In Adults With Rheumatoid ArthritisAn Open-Label Study To Evaluate The Potential Pharmacokinetic Interaction Between PLA-695 And Methotrexate When Coadministered Orally To Adult Subjects With Rheumatoid ArthritisArthritis, RheumatoidDrug: PLA-695Wyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 Years75 YearsBothPhase 1United States;Canada
1048NCT00392951
(ClinicalTrials.gov)
December 200624/10/2006Sirolimus for Autoimmune Disease of Blood CellsSirolimus for Patients With Chronic and/or Refractory Autoimmune Cytopenias: A Pilot SeriesAutoimmune Pancytopenia;Autoimmune Lymphoproliferative Syndrome (ALPS);Evans Syndrome;Idiopathic Thrombocytopenic Purpura;Anemia, Hemolytic, Autoimmune;Autoimmune Neutropenia;Lupus Erythematosus, Systemic;Inflammatory Bowel Disease;Rheumatoid ArthritisDrug: sirolimusChildren's Hospital of PhiladelphiaNULLCompleted1 Year30 YearsAll30Phase 1/Phase 2United States
1049NCT00430495
(ClinicalTrials.gov)
December 200630/1/2007A Phase 2 Dose-finding Study of Atacicept in Subjects With Rheumatoid Arthritis (AUGUST I)A Randomized, Double-blind, Placebo-controlled, Multicentre, Phase II Dose-finding Study of Atacicept Given Subcutaneously in Subjects With Rheumatoid Arthritis and Inadequate Response to TNFa Antagonist TherapyRheumatoid ArthritisDrug: Atacicept;Drug: Placebo matched to ataciceptEMD SeronoMerck KGaACompleted18 YearsN/AAll256Phase 2United States;Canada
1050NCT00484289
(ClinicalTrials.gov)
December 20067/6/2007A Phase III Study of Abatacept in Japanese Subjects With Rheumatoid ArthritisA Phase III, Multi-center, Open-label, Uncontrolled, Long-term Study to Evaluate the Safety of Abatacept (BMS-188667) in Japanese Subjects With Rheumatoid Arthritis Having Completed Clinical Studies IM101-071, IM101-034, and Also Special DMARD FailuresRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted20 YearsN/AAll217Phase 3Japan
1051NCT00396812
(ClinicalTrials.gov)
November 20066/11/2006Rituximab for the Treatment of Early Rheumatoid Arthritis (RA)An Open Label, Single Arm, Single Center, Phase I/II Trial of Rituximab (a Monoclonal Antibody to CD20) for the Treatment of Early Rheumatoid ArthritisRheumatoid ArthritisDrug: RituximabNational Institute of Allergy and Infectious Diseases (NIAID)Autoimmunity Centers of ExcellenceTerminated18 YearsN/AAll4Phase 1/Phase 2United States
1052NCT00761514
(ClinicalTrials.gov)
November 200625/9/2008Evaluation of Quality of Life Changes in Puerto Rican Subjects With Active Rheumatoid Arthritis Treated With HumiraEvaluation of Quality of Life Changes in Puerto Rican Subjects With Active Rheumatoid Arthritis Treated With Humira as Their First Anti-TNF Monoclonal Antibody (VIVIR)Rheumatoid ArthritisDrug: Humira (adalimumab)AbbottNULLTerminated18 YearsN/AAll14Phase 4Puerto Rico
1053NCT00424346
(ClinicalTrials.gov)
November 200617/1/2007Efficacy, Safety and Tolerability of ACZ885 in Patients With Active Rheumatoid ArthritisA 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Dose-finding Study to Evaluate the Efficacy, Safety and Tolerability of ACZ885 (Anti-interleukin-1beta Monoclonal Antibody) With Three Different Dose Regimens in Patients With Active Rheumatoid Arthritis Despite Stable Treatment With Methotrexate Including 76-week and 96-week ExtensionsRheumatoid ArthritisDrug: Canakinumab;Drug: PlaceboNovartisNULLCompleted18 YearsN/AAll274Phase 2United States;Austria;Belgium;Canada;Germany;Spain;Finland
1054NCT02079532
(ClinicalTrials.gov)
November 20064/3/2014A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF InhibitorAn Open-label Study to Evaluate the Safety of MabThera, and Its Effect on Treatment Response, in Patients With Rheumatoid Arthritis Following Inadequate Response to a Single Anti-TNF AgentRheumatoid ArthritisDrug: rituximab [MabThera]Hoffmann-La RocheNULLCompleted18 Years75 YearsAll302Phase 3Germany
1055NCT00072982
(ClinicalTrials.gov)
November 200613/11/2003Treatment of Rheumatoid Arthritis With Marine and Botanical OilsTreatment of Rheumatoid Arthritis With Marine and Botanical OilsRheumatoid ArthritisDrug: fish oil;Drug: borage seed oil;Drug: combination fish oil and borage seed oilNational Center for Complementary and Integrative Health (NCCIH)NULLActive, not recruiting18 Years85 YearsBoth156Phase 3United States
1056NCT00395577
(ClinicalTrials.gov)
November 20061/11/2006A Study in Rheumatoid Arthritis With an Investigational Oral p38 MAP Kinase Inhibitor VX-702A Phase 2, 12-Week, Randomized, Placebo-Controlled Study to Evaluate the Antiinflammatory Effects of VX-702 When Administered Concomitantly With MethotrexateRheumatoid ArthritisDrug: VX-702Vertex Pharmaceuticals IncorporatedNULLCompleted18 Years75 YearsBoth120Phase 2Bulgaria;Croatia;Former Serbia and Montenegro;Poland;Russian Federation;Slovenia
1057NCT00346216
(ClinicalTrials.gov)
October 4, 200628/6/2006Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or NaproxenA Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And IbuprofenArthritis, RheumatoidDrug: celecoxib;Drug: Ibuprofen;Drug: NaproxenPfizer's Upjohn has merged with Mylan to form Viatris Inc.The Cleveland ClinicCompleted18 YearsN/AAll24081Phase 4United States;Australia;Brazil;Canada;Colombia;Costa Rica;Hong Kong;Mexico;Panama;Peru;Philippines;Taiwan;Ukraine
1058NCT00393146
(ClinicalTrials.gov)
October 200624/10/2006A Study To Investigate The Effect Of 28 Days Of Dosing With GW856553 On Patients With Rheumatoid ArthritisA Randomized, Double Blind, Placebo Controlled Study to Investigate the Safety and Tolerability and Clinical Activity of 28 Days of Oral Repeat Dosing With GW856553 at 7.5mg BID in Subjects With Active Rheumatoid Arthritis on Stable Anti-rheumatic Therapy.Arthritis, RheumatoidDrug: GW856553GlaxoSmithKlineNULLCompleted18 YearsN/ABoth57Phase 2Romania;Russian Federation;Spain
1059NCT00749645
(ClinicalTrials.gov)
October 20067/9/2008Efficacy Study of FANG(30) for Active Rheumatoid Arthritis in Adult PatientsClinical Phase II Pilot Study of the Efficacy of FANG(30) to Treat Active Rheumatoid Arthritis in Adult PatientsArthritis, RheumatoidDrug: FANG(30);Drug: PlaceboJuan C. Bertoglio, MDFondo Nacional de Desarrollo Científico y Tecnológico, ChileCompleted18 Years70 YearsBoth60Phase 2Chile
1060NCT00399282
(ClinicalTrials.gov)
October 200613/11/2006Omega-3 and Vitamin E Supplementation in Patients With Rheumatoid ArthritisComparison of the Effects of Simultaneous Administration of Vitamin E and Omega-3 Fatty Acids in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Omega-3 and Vitamin E supplementationShahid Beheshti Medical UniversityNULLCompleted16 Years75 YearsBoth75Phase 1Iran, Islamic Republic of
1061NCT00488475
(ClinicalTrials.gov)
September 200618/6/2007Observational Trial With EnbrelA 1 Year Observational Study of the Use of Etanercept in Routine German Clinical Practice to Treat Rheumatoid Arthritis Patients: a Health Economic, Safety and Effectiveness EvaluationRheumatoid ArthritisDrug: etanerceptPfizerNULLCompleted18 YearsN/AAll4945N/AGermany
1062NCT00361335
(ClinicalTrials.gov)
September 20064/8/2006A Study of Safety and Effectiveness of Golimumab in Participants With Active Rheumatoid Arthritis Despite Methotrexate TherapyA Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Golimumab, a Fully Human Anti-TNFa Monoclonal Antibody, Administered Intravenously, in Subjects With Active Rheumatoid Arthritis Despite Methotrexate TherapyRheumatoid ArthritisDrug: Golimumab;Drug: Methotrexate;Drug: PlaceboCentocor, Inc.Schering-PloughCompleted18 YearsN/AAll643Phase 3United States;Argentina;Australia;Colombia;Germany;Hungary;Latvia;Lithuania;Malaysia;Malta;Mexico;New Zealand;Peru;Poland;Ukraine;Belgium;Russian Federation
1063NCT01308255
(ClinicalTrials.gov)
September 20063/3/2011Infliximab as Induction Therapy in Early Rheumatoid Arthritis (IDEA)A Multi-centre Randomised Double Blind Placebo Controlled Study Comparing Two Regimens of Combination Therapy in Early DMARD Naive Rheumatoid Arthritis.Rheumatoid ArthritisDrug: Infliximab;Drug: Methylprednisolone;Drug: Methotrexate;Dietary Supplement: Folic acidUniversity of LeedsNULLCompleted18 Years80 YearsAll112Phase 4United Kingdom
1064NCT00367211
(ClinicalTrials.gov)
September 200618/8/2006Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers.A 6-Month, Phase 3, Randomized, Double-Blind, Parallel-Group, Controlled, Multi-Center Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers.Osteoarthritis;Rheumatoid Arthritis;Ankylosing SpondylitisDrug: PN 200 tablets (500 mg naproxen and 20 mg omeprazole);Drug: Naproxen 500 mg tablets (PN 200 minus omeprazole)POZENNULLCompleted18 YearsN/ABoth400Phase 3United States
1065NCT00361634
(ClinicalTrials.gov)
September 20064/8/2006Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Measure Response to Etanercept in Rheumatoid ArthritisDCE-MRI of the Wrist to Measure Short-Term Responses in Rheumatoid Arthritis Subjects Treated With EtanerceptRheumatoid ArthritisDrug: EtanerceptAmgenNULLCompleted18 YearsN/AAll14Phase 1United States;United Kingdom
1066NCT01303874
(ClinicalTrials.gov)
September 200624/2/2011Etanercept and Methotrexate in Patients to Induce Remission in Early Arthritis (EMPIRE)A Multicentre Randomised Trial Of Etanercept And Methotrexate To Induce Remission In Early Inflammatory ArthritisRheumatoid Arthritis;Inflammatory ArthritisDrug: Etanercept (ETN);Drug: PlaceboUniversity of LeedsNULLCompleted18 Years80 YearsAll112Phase 4United Kingdom
1067NCT01126541
(ClinicalTrials.gov)
September 200618/5/2010SMART Study: A Study of Re-treatment With MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Failed on Anti-TNF Alfa TherapyA Comparative Study to Assess the Effect of Retreatment With 2 Doses of MabThera on Disease Activity Score in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response or Intolerance to antiTNF-alfa Therapy.(SMART)Rheumatoid ArthritisDrug: rituximabHoffmann-La RocheNULLCompleted18 YearsN/AAll224Phase 3France
1068NCT00369473
(ClinicalTrials.gov)
September 200624/8/2006Long-Term Assessment of Safety and Physical Function With AMG 108 in RAA Long-Term Assessment of Safety and Physical Function With AMG 108 Subcutaneous Monthly Treatment in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: AMG 108AmgenNULLCompleted18 YearsN/ABoth690Phase 2Australia;Belgium;Canada;Czech Republic;Estonia;France;Hungary;Ireland;Italy;Latvia;Mexico;Netherlands;Poland;Puerto Rico;Slovakia;Spain;United Kingdom;United States
1069NCT00588393
(ClinicalTrials.gov)
September 200622/12/2007FolateScan in Autoimmune DiseaseStudy of the Efficacy and Safety of FolateScan (Technetium TC99m EC20) in Patients With Rheumatoid Arthritis and Other Inflammatory DiseasesRheumatoid Arthritis;Osteoarthritis;Multiple Sclerosis;Crohn's Disease;Systemic Lupus ErythematosusDrug: FolateScan (Technetium Tc 99mEC20)Mayo ClinicEndocyteCompleted18 YearsN/ABoth75Phase 2United States
1070NCT02006706
(ClinicalTrials.gov)
August 10, 20065/12/2013A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD TherapyAn Open-label Study to Evaluate the Effect of MabThera in Combination With Methotrexate on Disease Activity in Patients With Active Rheumatoid Arthritis After DMARD Treatment FailureRheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: methotrexate;Drug: methylprednisoloneHoffmann-La RocheNULLCompleted18 Years80 YearsAll15Phase 3Serbia
1071NCT00369928
(ClinicalTrials.gov)
August 200629/8/2006Evaluation of 2 Oral Doses of PG-760564 in Rheumatoid Arthritis (RA) Patients Receiving MethotrexateA Multicenter, Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of 2 Oral Doses, 25 mg Twice Daily and 100 mg Twice Daily, of PG-760564 in Adult Patients With RA Receiving MethotrexateRheumatoid ArthritisDrug: PG-760564;Drug: Placebo doseProcter and GambleNULLCompleted18 Years70 YearsAll254Phase 2United States;Czech Republic;Hungary;Netherlands;Poland;United Kingdom
1072NCT00326339
(ClinicalTrials.gov)
August 200612/5/2006Treatment of Arthritis With Syk Kinase Inhibition (TASKI-1)A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Ascending Dose, Dose Ranging Study to Evaluate Up to Three Doses of R935788 in Rheumatoid Arthritis Patients Failing to Respond to MethotrexateRheumatoid ArthritisDrug: R788;Drug: PlaceboRigel PharmaceuticalsNULLCompleted18 Years75 YearsBoth189Phase 2United States;Mexico
1073NCT01272908
(ClinicalTrials.gov)
July 18, 20067/1/2011A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Failed on One Prior Anti-TNF Therapy (RESET)Rituximab Phase IIIb Open-label, Multi-centre Assessment of Safety and Effectiveness in Patients With RA Following an Inadequate Response to One Prior Anti-TNF Inhibitor (RESET)Rheumatoid ArthritisDrug: rituximabHoffmann-La RocheNULLCompleted18 Years80 YearsAll120Phase 3Canada;Sweden
1074NCT00555542
(ClinicalTrials.gov)
July 20067/11/2007An Analysis of Peripheral Blood T Cell Subsets on Rheumatoid ArthritisB Cell Depletion Therapy in Rheumatoid Arthritis: An Analysis of Peripheral Blood T Cell SubsetsRheumatoid ArthritisDrug: rituximabChinese University of Hong KongNULLCompleted21 Years70 YearsBoth10Phase 2China
1075NCT00445770
(ClinicalTrials.gov)
July 20068/3/2007Study Evaluating the Efficacy and Safety of Etanercept and Methotrexate in Japanese Subjects With Rheumatoid ArthritisA Randomized, Double-Blind, Multicenter, Comparative Study Evaluating the Efficacy and Safety of Etanercept and Methotrexate in Japanese Subjects With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: Etanercept;Drug: MethotrexatePfizerNULLCompleted20 Years75 YearsAll550Phase 3Japan
1076NCT00369187
(ClinicalTrials.gov)
July 200625/8/2006Study of a Large Protein Molecule Administered With Escalating Doses of Recombinant Human HyaluronidaseRheumatoid ArthritisDrug: large protein moleculeHalozyme TherapeuticsNULLCompleted18 YearsN/ABoth15Phase 4United States
1077NCT01685424
(ClinicalTrials.gov)
June 30, 200623/8/2012Etoricoxib Prescribing Patterns and Adverse Events of Interest in Primary Care in the United Kingdom (MK-0663-162 AM1)Etoricoxib Prescribing Patterns and Adverse Events of Interest During Etoricoxib Treatment in UK Primary Care; an Updated AnalysisOsteoarthritis;Rheumatoid Arthritis;Ankylosing Spondylitis;Gout;ArthritisDrug: EtoricoxibOrganon and CoNULLCompletedN/AN/AAll79189United States
1078NCT00439062
(ClinicalTrials.gov)
June 200620/2/2007Treatment of Rheumatoid Arthritis With RoxithromycinTreatment of Rheumatoid Arthritis With RoxithromycinRheumatoid ArthritisDrug: RoxithromycinNazilli State HospitalNULLCompleted18 Years70 YearsBoth100Phase 4Turkey
1079NCT00424294
(ClinicalTrials.gov)
June 200618/1/2007A Study Of CP-195543 And Celecoxib Dual Therapy In Subjects With Rheumatoid ArthritisA Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of CP-195543 And Celecoxib Dual Therapy In The Treatment Of The Signs And Symptoms Of Rheumatoid Arthritis In Subjects Who Are Inadequately Controlled On MethotrexateArthritis, RheumatoidDrug: CP-195,543;Drug: celecoxib;Drug: MethotrexatePfizerNULLTerminated18 YearsN/AAll70Phase 2United States
1080NCT00443950
(ClinicalTrials.gov)
June 20065/3/2007Study Evaluating the Efficacy and Safety of Etanercept in Chinese Subjects With Rheumatoid ArthritisA Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Etanercept in Chinese Subjects With Active Rheumatoid Arthritis Receiving MethotrexateArthritis, RheumatoidDrug: EtanerceptWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/ABoth150Phase 3China
1081NCT00280917
(ClinicalTrials.gov)
June 200623/1/2006Oral CF101 and Methotrexate Treatment in Rheumatoid Arthritis PatientsRandomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Safety and Efficacy of Daily CF101 Administered Orally, When Added to Weekly Methotrexate, in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CF101Can-Fite BioPharmaNULLCompleted18 Years75 YearsAll254Phase 2United States;Bulgaria;Israel;Poland;Romania;Serbia;Ukraine;Former Serbia and Montenegro
1082NCT00345748
(ClinicalTrials.gov)
June 200623/6/2006A Study of Abatacept in Japanese Patients With Active Rheumatoid Arthritis While Receiving MethotrexateA Phase II, Multi-center, Randomized, Double-Blind, Placebo Controlled, Dose Response Study to Evaluate the Safety and Efficacy of Two Different Doses of Abatacept (BMS-188667) Administered Intravenously to Japanese Subjects With Active Rheumatoid Arthritis While Receiving MethotrexateRheumatoid ArthritisDrug: Abatacept;Drug: PlaceboBristol-Myers SquibbNULLCompleted20 YearsN/ABoth194Phase 2Japan
1083NCT00497614
(ClinicalTrials.gov)
May 20064/7/2007Positron Emission Tomography in Rheumatoid Arthritis With Adalimumab (PETRA)18F-FDG Positron Emission Tomography to Study the Response to Adalimumab in Rheumatoid Arthritis. A Monocentric Pilot StudyRheumatoid ArthritisDrug: adalimumabUniversity Hospital, ToursNULLCompleted18 Years75 YearsBoth8N/AFrance
1084NCT00380601
(ClinicalTrials.gov)
May 200625/9/2006Phase?Open-label Study of MRA for Rheumatoid Arthritis(RA)An Open-label, Phase? Study to Evaluate the Efficacy and Safety of MRA in Patients With RARheumatoid ArthritisDrug: MRA(Tocilizumab)Chugai PharmaceuticalNULLCompleted20 YearsN/ABoth20Phase 3Japan
1085NCT00303563
(ClinicalTrials.gov)
April 200616/3/2006A Study of P38 Inhibitor (4) Monotherapy in Patients With Active Rheumatoid ArthritisA Randomized, Double-blind Study to Compare the Effect of RO4402257 Monotherapy and Methotrexate Monotherapy on Disease Response in Patients With Active Rheumatoid Arthritis.Rheumatoid ArthritisDrug: P38 Inhibitor (4);Drug: PlaceboHoffmann-La RocheNULLCompleted18 YearsN/ABoth204Phase 2United States;Canada;Croatia;Czech Republic;France;Italy;Mexico;Romania;Serbia;South Africa;Spain;Taiwan;Former Serbia and Montenegro
1086NCT00319917
(ClinicalTrials.gov)
April 200627/4/2006A Double Blind Placebo Controlled Study to Assess the Efficacy on Joint Damage in RA PatientsFK506 Phase 4 Study: A Double Blind Placebo Controlled Study to Assess the Efficacy on Joint Damage in RA PatientsRheumatoid ArthritisDrug: tacrolimus;Drug: placeboAstellas Pharma IncNULLCompleted20 Years64 YearsBoth123Phase 4Japan
1087NCT00308282
(ClinicalTrials.gov)
March 28, 200628/3/2006A Multi-Site Study to Evaluate the Safety and Effect of Study Drug on Participants With Rheumatoid ArthritisPhase II Study of Safety and Efficacy of Intravenous LY2127399 in Patients With Rheumatoid Arthritis Treated With MethotrexateArthritis, RheumatoidDrug: LY2127399;Drug: PlaceboEli Lilly and CompanyNULLCompleted18 Years75 YearsAll136Phase 2Romania
1088NCT00293826
(ClinicalTrials.gov)
March 200617/2/2006A Multiple Dose Study to Evaluate Subcutaneous AMG 108 in Subjects With Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneous AMG 108 in Subjects With Rheumatoid Arthritis.Rheumatoid ArthritisDrug: AMG 108;Drug: PlaceboAmgenNULLCompleted18 Years70 YearsBoth813Phase 2United States;Australia;Austria;Belgium;Canada;Czech Republic;Estonia;France;Hungary;Ireland;Italy;Latvia;Mexico;Netherlands;Poland;Slovakia;Spain;Sweden;United Kingdom;Puerto Rico
1089NCT00394589
(ClinicalTrials.gov)
March 200631/10/2006Re³ (Re-Cube: Retain Remicade® Response)(Study P04249AM3)Randomised Controlled Trial Evaluating Strategies to Optimize Disease Activity Control in RA Patients Treated With Infliximab in Clinical Practice.Rheumatoid ArthritisDrug: Infliximab Control;Drug: Infliximab Increased Frequency;Drug: Infliximab Increased DoseMerck Sharp & Dohme Corp.Integrated Therapeutics GroupTerminated18 YearsN/AAll43Phase 3Austria;Belgium;Denmark;France;Germany;Netherlands;Sweden;Turkey
1090NCT00286689
(ClinicalTrials.gov)
February 3, 20061/2/2006Effects of Growth Hormone in Chronically Ill ChildrenHurler Syndrome;Cerebral Palsy;Juvenile Rheumatoid Arthritis;Crohn Disease;HIV InfectionsDrug: Growth Hormone;Procedure: Whole body Protein turnover;Procedure: DEXA scanUniversity of Texas Southwestern Medical CenterNULLWithdrawn3 Years17 YearsAll0N/AUnited States
1091NCT00299546
(ClinicalTrials.gov)
February 20063/3/2006A Study of the Safety and Efficacy of Golimumab (CNTO 148) in Subjects With Active Rheumatoid Arthritis Previously Treated With Biologic Anti-TNFa Agent(s)A Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Golimumab, a Fully Human Anti-TNFa Monoclonal Antibody, Administered Subcutaneously in Subjects With Active Rheumatoid Arthritis and Previously Treated With Biologic Anti- TNFa Agent(s)Arthritis, RheumatoidDrug: Placebo;Biological: Golimumab 50 mg;Biological: Golimumab 100 mgCentocor, Inc.Schering-PloughCompleted18 YearsN/AAll461Phase 3United States;Australia;Austria;Canada;Finland;Germany;Netherlands;New Zealand;Spain;United Kingdom;France;Switzerland
1092NCT00287794
(ClinicalTrials.gov)
February 20066/2/2006Quality of Sleep in Patients With Rheumatoid ArthritisStudy on the Quality of Sleep in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: diazepam, melatoninKobe UniversityNULLRecruiting17 YearsN/ABoth1000Japan
1093NCT00296257
(ClinicalTrials.gov)
February 200622/2/2006Assessment of Safety, Pharmacokinetics and Efficacy in a Combination Treatment With SMP-114A Phase 2, Multi-Centre, Randomised, Double Blind, Placebo Controlled Study Evaluating the Efficacy, Safety and Pharmacokinetics of Two Doses of a Candidate Disease Modifying Anti-Rheumatic Drug (DMARD), (SMP-114 120 mg and 240 mg Once Daily), Administered in Combination With Ongoing Methotrexate Treatment in Patients With Active Rheumatoid Arthritis.Rheumatoid Arthritis (RA)Drug: SMP-114Dainippon Sumitomo Pharma Europe LTd.NULLTerminated18 YearsN/ABoth312Phase 2Czech Republic;Germany;Hungary;Netherlands;Poland;United Kingdom
1094NCT00422383
(ClinicalTrials.gov)
February 200615/1/2007A Study of Retreatment With MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (RA)A Randomized, Double-blind Study to Evaluate the Effect of Various Re-treatment Regimens of MabThera in Combination With Methotrexate on Treatment Response in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate.Rheumatoid ArthritisDrug: rituximab [MabThera/Rituxan]Hoffmann-La RocheNULLCompleted18 YearsN/AAll378Phase 3Australia;Belgium;Brazil;Canada;China;Finland;France;Germany;Hungary;Italy;Netherlands;New Zealand;Slovakia;South Africa;Spain;Taiwan;Thailand;United Kingdom;Switzerland;United States
1095NCT00502996
(ClinicalTrials.gov)
February 200617/7/2007A Non-Comparative Study to Assess the Safety of MabThera (Rituximab) in Patients With Rheumatoid Arthritis.Multicenter Non-Comparative Expanded Access Program of to Assess Safety of Rituximab (Mab Anti Cd-20) in Patients With Rheumatoid Arthritis (Ser)Rheumatoid ArthritisDrug: Methotrexate;Drug: rituximab [MabThera/Rituxan]Hoffmann-La RocheNULLCompleted18 YearsN/AAll246Phase 3Argentina;Brazil;Chile;Colombia;Ecuador;El Salvador;Mexico;Peru;Uruguay;Venezuela
1096NCT00282308
(ClinicalTrials.gov)
January 23, 200624/1/2006A Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background MethotrexateA Phase II, Randomized, Parallel-group, Open-label, Multicenter Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background MethotrexateRheumatoid ArthritisDrug: Rituximab;Drug: Methotrexate;Drug: Methylprednisone;Biological: C. albicans;Biological: Tetanus toxoid adsorbed booster vaccine;Biological: 23-valent pneumococcal polysaccharide vaccine;Biological: Keyhole limpet hemocyaninGenentech, Inc.NULLCompleted18 Years65 YearsAll103Phase 2United States
1097NCT03496831
(ClinicalTrials.gov)
January 1, 20065/4/2018Predicting Hospitalized Infection in Patients With Chronic Inflammatory Arthritis Treated With Biological DrugsDevelopment of a Prediction Model for the Risk of Hospitalized Infection in Patients With Chronic Inflammatory Arthritis Treated With Biological DrugsRheumatoid Arthritis;Spondyloarthritis;Psoriatic ArthritisDrug: Biologic AgentsSimon KrabbeUniversity of Aarhus;Zealand University Hospital;University of Southern DenmarkCompleted18 YearsN/AAll7500NULL
1098NCT00254293
(ClinicalTrials.gov)
January 200615/11/2005Study to Assess Steady-State Trough Concentrations, Safety, and Immunogenicity of Abatacept After Subcutaneous (SC) Administration to Subjects With Rheumatoid Arthritis (RA)A Study to Assess the Steady-State Trough Serum Concentration, Safety, and Immunogenicity of Abatacept (BMS-188667) Administered Subcutaneously in Subjects With Active Rheumatoid Arthritis Who Are Receiving Disease Modifying Ant-Rheumatic Drugs (DMARDs)Rheumatoid ArthritisDrug: Abatacept or Placebo (both as IV & SC Solution);Drug: Abatacept or Placebo (both as IV & SC solution);Drug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll87Phase 1/Phase 2United States
1099NCT00422942
(ClinicalTrials.gov)
January 200615/1/2007A Pharmacokinetic and Pharmacodynamic Study of MabThera (Rituximab) Plus Methotrexate in Patients With Rheumatoid Arthritis (RA)An Open-label, Exploratory Study of the Pharmacokinetic and Pharmacodynamic Activity of MabThera in Combination With Methotrexate in Synovial Tissue and in Peripheral Blood of Patients With Active Rheumatoid Arthritis.Rheumatoid ArthritisDrug: rituximab [MabThera/Rituxan];Drug: MethotrexateHoffmann-La RocheNULLTerminated18 Years80 YearsAll3Phase 2Netherlands;Spain
1100NCT00379990
(ClinicalTrials.gov)
January 200621/9/2006A Study To Investigate GW274150 Or Prednisolone In Rheumatoid Arthritis Taken Repeatedly For 28 Days.A Randomised, Double-blind, Placebo-controlled, Parallel Group Study to Investigate the Safety, Tolerability, Pharmacokinetics and Effect on Synovial Thickness and Vascularity of 28 Days Repeat Dosing of GW274150 or 7.5mg Prednisolone in RA Subjects.Arthritis, RheumatoidDrug: GW274150;Drug: Prednisolone;Other: PlaceboGlaxoSmithKlineNULLCompleted18 YearsN/ABoth48Phase 2Serbia;United Kingdom
1101NCT00299104
(ClinicalTrials.gov)
January 20062/3/2006A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid ArthritisA Randomized, Phase 3, Controlled, Double-Blind, Parallel-Group, Multicenter Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate (MTX) Compared to MTX Alone, in Methotrexate-Naive Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: folate;Drug: methotrexate;Drug: methylprednisolone;Drug: placebo;Drug: rituximabGenentech, Inc.Hoffmann-La RocheCompleted18 Years80 YearsAll755Phase 3United States
1102NCT00264147
(ClinicalTrials.gov)
January 20069/12/2005Rheumatoid Arthritis Dose Ranging Study (0663-086)(COMPLETED)A Randomized, Placebo-Controlled, Double-Blind, Multicenter, Parallel-Group, 12-Week Study to Assess the Clinically Effective Dose Range of Etoricoxib and to Assess Its Safety and Tolerability in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: etoricoxib;Drug: Comparator: placebo;Drug: Comparator: diclofenacOrganon and CoNULLCompleted18 YearsN/AAll761Phase 2Canada;Colombia;Puerto Rico;Switzerland;United States
1103NCT00346294
(ClinicalTrials.gov)
January 200627/6/2006An Open-Label Study to Assess the Rate of Failure of an Enbrel® (Etanercept) SureClick™ Auto-injector in Subjects With Rheumatoid ArthritisAn Open-Label Study to Assess the Rate of Failure of an Enbrel® (Etanercept) SureClick™ Auto-injector in Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: EtanerceptAmgenImmunex CorporationCompleted18 YearsN/AAll115Phase 4United States
1104NCT00234234
(ClinicalTrials.gov)
January 20065/10/2005Predictors of the Response to Adalimumab in Rheumatoid ArthritisPredictors of the Response to Adalimumab in Rheumatoid ArthritisRheumatoid ArthritisDrug: AdalimumabUniversity Hospital, RouenNULLCompleted18 YearsN/ABoth200Phase 4France
1105NCT00266227
(ClinicalTrials.gov)
January 200614/12/2005A Study of Retreatment With Rituximab in Patients With Rheumatoid Arthritis Receiving Background MethotrexateA Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Retreatment With Rituximab in Subjects With Rheumatoid Arthritis Receiving Background MethotrexateRheumatoid ArthritisDrug: placebo;Drug: rituximab;Drug: methotrexate;Drug: folateGenentech, Inc.NULLCompleted18 Years80 YearsAll559Phase 3United States
1106NCT00724243
(ClinicalTrials.gov)
January 200625/7/2008Safety and Effectiveness of Infliximab in Slovakia When Used for Rheumatoid Arthritis (Study P04741)(COMPLETED)Remicade Treatment Registry in Rheumatoid Arthritis IRheumatoid ArthritisDrug: InfliximabMerck Sharp & Dohme Corp.NULLCompletedN/AN/AAll33N/ASlovakia
1107NCT00264550
(ClinicalTrials.gov)
December 200511/12/2005An Efficacy and Safety Study of Golimumab in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyA Multicenter, Randomized, Double-blind, Placebo-controlledTrial of Golimumab, a Fully Human Anti-TNFa MonoclonalAntibody, Administered Subcutaneously, in Subjects With ActiveRheumatoid Arthritis Despite Methotrexate TherapyRheumatoid ArthritisDrug: Golimumab 100 mg;Drug: Golimumab 50 mg;Drug: Methotrexate;Drug: Placebo injection;Drug: Placebo capsulesCentocor, Inc.Schering-PloughCompleted18 YearsN/AAll444Phase 3United States;Argentina;Australia;Canada;Chile;Germany;Hungary;Korea, Republic of;Mexico;New Zealand;Poland;Taiwan;Brazil;India;Turkey
1108NCT00642629
(ClinicalTrials.gov)
December 200520/3/2008A Randomized, Double-blind, Placebo-controlled Clinical Study of the Oral IL-12/23 Inhibitor, STA-5326 Mesylate, Administered to Patients With Rheumatoid Arthritis to Determine Safety, Tolerability, Pharmacokinetic and Synovial Tissue OutcomesActive, Moderate to Severe Rheumatoid ArthritisDrug: STA 5326 mesylate;Drug: PlaceboSynta Pharmaceuticals Corp.NULLCompleted18 YearsN/ABoth35Phase 2Netherlands
1109NCT00281294
(ClinicalTrials.gov)
December 200520/1/2006A Phase 2 Study to Evaluate the Safety, Tolerability, and Activity of Fontolizumab in Subjects With Active Rheumatoid ArthritisA Phase 2 Study to Evaluate the Safety, Tolerability, and Activity of Fontolizumab in Subjects With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: FontolizumabPDL BioPharma, Inc.NULLTerminated18 YearsN/ABoth40Phase 2United States
1110NCT00264537
(ClinicalTrials.gov)
December 200511/12/2005A Study of the Safety and Efficacy of Golimumab in Subjects With Rheumatoid Arthritis That Are Methotrexate-naiveA Multicenter, Randomized, Double-blind, Placebo-controlledTrial of Golimumab, a Fully Human Anti-TNFa MonoclonalAntibody, Administered Subcutaneously, in Methotrexate-naive Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Placebo injections;Drug: Placebo capsules;Drug: Methotrexate capsules;Biological: Golimumab 50 mg injections;Biological: Golimumab 100 mg injectionsCentocor, Inc.Schering-PloughCompleted18 YearsN/AAll637Phase 3United States;Argentina;Australia;Austria;Belgium;Canada;Chile;Hungary;India;Korea, Republic of;Malaysia;New Zealand;Philippines;Poland;Russian Federation;Singapore;Spain;Taiwan;Thailand;Ukraine;United Kingdom;Brazil;Mexico;Turkey
1111NCT00320450
(ClinicalTrials.gov)
November 200528/4/2006SB-681323 In Subjects With Rheumatoid ArthritisA Randomised, Parallel Group, Placebo-controlled, Double Blind Study to Assess the Safety and Tolerability of SB-681323 at 7.5mg Daily Dose for 28 Days and Its Effect on the Levels of Serum C-reactive Protein (CRP) in Subjects With Rheumatoid Arthritis (RA)Arthritis, RheumatoidDrug: SB-681323GlaxoSmithKlineNULLCompleted18 YearsN/ABoth78Phase 2Denmark;Germany;Hong Kong;Italy;Norway;Poland;Spain;Sweden;United Kingdom;Hungary
1112NCT00256919
(ClinicalTrials.gov)
November 200521/11/2005Single Dose Study Of GW856553 On A Protein That Is An Indicator For Rheumatoid Arthritis (RA)A Randomised, Placebo-controlled, Parallel Group Single Dose Study of GW856553 in Patients With Active RA to Investigate the C-Reactive Protein (CRP) Dose Response RelationshipArthritis, RheumatoidDrug: GW856553GlaxoSmithKlineNULLCompleted18 YearsN/ABoth51Phase 2Bulgaria;Germany;Spain;Sweden;Ukraine
1113NCT00380744
(ClinicalTrials.gov)
November 200522/9/2006A Safety and Pharmacokinetics Study in Participants With Rheumatoid ArthritisA Phase 1b/2 Multiple-Dose Safety Study and Pharmacokinetic/ Pharmacodynamic Study of LY2189102 in Patients With Rheumatoid ArthritisArthritis, RheumatoidDrug: LY2189102;Drug: placeboEli Lilly and CompanyNULLCompleted18 Years75 YearsAll121Phase 1/Phase 2United States;Poland;Argentina;Hungary;Spain
1114NCT00316771
(ClinicalTrials.gov)
November 200520/4/2006A Study of P38 Inhibitor (4) in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate TherapyA Randomized, Double-blind, Placebo-controlled, Study to Determine the Efficacy and Safety of 5 Dose Regimens of RO4402257 in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate (MTX) Therapy.Rheumatoid ArthritisDrug: P38 Inhibitor (4) 150mg;Drug: P38 Inhibitor (4) 25mg;Drug: P38 Inhibitor (4) 300mg;Drug: P38 Inhibitor (4) 50mg;Drug: P38 Inhibitor (4) 75mg;Drug: PlaceboHoffmann-La RocheNULLCompleted18 YearsN/ABoth374Phase 2South Africa;Spain;United Kingdom;United States;Australia;Brazil;Canada;Estonia;Germany;Greece;Ireland;Mexico;New Zealand;Poland
1115NCT00162292
(ClinicalTrials.gov)
November 20059/9/2005Multiple Ascending Dose Study of BMS-582949 in Patients With Stable Rheumatoid Arthritis on the Methotrexate BackgroundMultiple Ascending Dose Study of BMS-582949 in Patients With Stable Rheumatoid Arthritis on the Methotrexate BackgroundRheumatoid ArthritisDrug: BMS-582949 and MethotrexateBristol-Myers SquibbNULLCompleted18 Years70 YearsBoth33Phase 1United States;Mexico
1116NCT00292422
(ClinicalTrials.gov)
November 200515/2/2006Dose-Escalating Study of BG9924 in Combination With Methotrexate in Active Rheumatoid ArthritisA Randomized, Blinded, Placebo-Controlled, Multicenter, Dose-Escalating Study to Evaluate the Safety, Tolerability and Pharmacokinetics of BG9924 When Given in Combination With Methotrexate to Subjects With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to DMARD TherapyRheumatoid ArthritisDrug: BG9924Biogen IdecNULLCompleted18 Years75 YearsBoth50Phase 2United States;Poland
1117NCT00299130
(ClinicalTrials.gov)
October 20053/3/2006A Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate Compared to Methotrexate Alone in Patients With Active Rheumatoid ArthritisA Randomized, Placebo Controlled, Double-blind, Parallel Group, International Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate, Compared to Methotrexate Monotherapy, in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Folate;Drug: Methotrexate;Drug: Methylprednisolone;Drug: Placebo;Drug: RituximabGenentech, Inc.Hoffmann-La RocheCompleted18 Years80 YearsAll511Phase 3United States
1118NCT02720120
(ClinicalTrials.gov)
October 200522/3/2016A Study of Ocrelizumab in Participants With Moderate to Severe Rheumatoid Arthritis (RA)A Randomized Placebo-Controlled, Multi-Center, Phase I/II Study of the Safety of Escalating Single Intravenous Doses of Ocrelizumab (rhuMAb 2H7, RO4964913, PRO70769) in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Stable Doses of Concomitant Methotrexate But With Unsatisfactory Clinical ResponseRheumatoid ArthritisDrug: Ocrelizumab;Drug: PlaceboHoffmann-La RocheNULLTerminated18 Years80 YearsBoth175Phase 1/Phase 2Australia;Belgium;Canada;Netherlands;New Zealand;Russian Federation;Spain;United Kingdom
1119NCT00241982
(ClinicalTrials.gov)
October 200518/10/2005Long-Circulating Liposomal Prednisolone Versus Pulse Intramuscular Methylprednisolone in Patients With Active Rheumatoid ArthritisLong-Circulating Liposomal Prednisolone Versus Pulse Intramuscular Methylprednisolone in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: long-circulating liposomal prednisoloneRadboud UniversityUtrecht UniversityCompleted18 YearsN/ABoth22Phase 2Netherlands
1120NCT00141102
(ClinicalTrials.gov)
October 200529/8/2005Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With ArthritisDouble-Blind, Triple Dummy, Parallel-Group, Randomized, Six-Month Study To Compare Celecoxib (200 Mg BID) With Diclofenac Sr (75 Mg BID) Plus Omeprazole (20 Mg QD) For Gastrointestinal Events In Subjects With Osteoarthritis And Rheumatoid Arthritis At High-Risk Of Gastrointestinal Adverse EventsOsteoarthritis;Arthritis, RheumatoidDrug: Celecoxib;Drug: Diclofenac + OmeprazolePfizer's Upjohn has merged with Mylan to form Viatris Inc.NULLCompleted18 YearsN/AAll4484Phase 4Belgium;Brazil;Canada;China;Colombia;Costa Rica;Croatia;Czechia;Ecuador;Estonia;France;Germany;Greece;Guatemala;Hong Kong;India;Korea, Republic of;Latvia;Lithuania;Netherlands;Panama;Peru;Portugal;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Ukraine;United Kingdom;Czech Republic;Former Serbia and Montenegro;Ireland
1121NCT00249041
(ClinicalTrials.gov)
October 20053/11/2005Enbrel Liquid Immunogenicity ProtocolOpen-label Study to Assess the Antibody Response to Etanercept Liquid in Subjects With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: 50 mg Etanercept;Drug: Enbrel liquidAmgenImmunex CorporationCompleted18 YearsN/ABoth447Phase 3United States;Canada
1122NCT00216177
(ClinicalTrials.gov)
September 200520/9/2005Comparison of Adalimumab and Infliximab Treatment of Rheumatoid ArthritisRandomised, Multicenter, Open-label, Parallel-group Study Comparing Adalimumab 40 mg s.c. Eow Versus Infliximab 3 mg/kg i.v. Every 6 Weeks in Rheumatoid Arthritis Patients With Unsustainable Clinical Response to Infliximab 3 mg/kg Every 8 WeeksRheumatoid ArthritisDrug: Infliximab;Drug: AdalimumabHvidovre University HospitalUniversity Hospital, Gentofte, CopenhagenRecruiting18 Years80 YearsBoth112Phase 4Denmark
1123NCT00691028
(ClinicalTrials.gov)
September 20053/6/2008Efficacy and Safety of Increased Dose of TA-650(Infliximab) in Patients With Rheumatoid ArthritisClinical Study to Assess the Efficacy and Safety of Increased Dose of TA-650(Infliximab) in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: TA-650 3 mg/kg;Drug: TA-650 6 mg/kg;Drug: TA-650 10 mg/kgMitsubishi Tanabe Pharma CorporationNULLCompleted20 Years75 YearsAll327Phase 3NULL
1124NCT00720798
(ClinicalTrials.gov)
September 200522/7/2008An Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients Completing Treatment in Tocilizumab Core StudiesLong-term Extension Study of Safety During Treatment With Tocilizumab (MRA) in Patients Completing Treatment in MRA Core StudiesRheumatoid ArthritisDrug: Tocilizumab;Drug: Disease-modifying anti-rheumatic drugs;Drug: Non-steroidal anti-inflammatory drugs;Drug: Oral corticosteroidsHoffmann-La RocheNULLCompleted18 YearsN/AAll2067Phase 3United States;Argentina;Australia;Belgium;Brazil;Canada;China;Costa Rica;Czech Republic;Denmark;Finland;France;Germany;Hong Kong;Iceland;Israel;Italy;Lithuania;Mexico;Netherlands;Norway;Panama;Peru;Portugal;Puerto Rico;Russian Federation;Serbia;Slovenia;South Africa;Spain;Sweden;Switzerland;Thailand;United Kingdom
1125NCT00141934
(ClinicalTrials.gov)
August 200531/8/2005A Multicentre Trial to Determine the Efficacy of AD 452 in RA Subjects.Phase II Randomised, Double-Blind, Multicentre, Placebo-Controlled, Dose-Ranging, Parallel Group Study to Compare the Efficacy, Safety and Tolerability of 3 Strengths of AD 452 in Adults With Active RA Who Are Currently Taking Methotrexate.Rheumatoid ArthritisDrug: AD 452SoseiNULLCompleted18 Years75 YearsBoth232Phase 2United States
1126NCT00370435
(ClinicalTrials.gov)
August 200517/8/2006Study Of 90mg Of GW274150 In Subjects Over 50 Years, Who Have Rheumatoid Arthritis (RA)An Open-label, Single Dose Study to Investigate the Safety, Tolerability and Pharmacokinetics of 90mg of GW274150 in Adult and Elderly RA Subjects.Arthritis, RheumatoidDrug: GW274150GlaxoSmithKlineNULLCompleted50 YearsN/AAll6Phase 2United Kingdom
1127NCT00111410
(ClinicalTrials.gov)
August 200520/5/2005Evaluating the Effect of Anakinra (r-metHuIL-1ra) on Vaccine AntibodyResponse in Subjects With Rheumatoid Arthritis (RA)A Multicenter, Double-Blind, Randomized, Placebo Controlled Study to Estimate the Effect of Anakinra (r-metHuIL-1ra) on Vaccine Antibody Response in Subjects With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Anakinra (r-metHuIL-1ra)AmgenNULLCompleted18 Years74 YearsBothPhase 4NULL
1128NCT00141830
(ClinicalTrials.gov)
August 200530/8/2005Study Evaluating ERB-041 With Methotrexate in Rheumatoid ArthritisA Randomized, Parallel, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of 3 Oral Doses of ERB-041 in Subjects With Rheumatoid Arthritis on a Background of Methotrexate TherapyRheumatoid ArthritisDrug: Methotrexate plus ERB-041 for 12 weeks;Drug: Placebo for 12 weeksWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 Years80 YearsAll159Phase 2United States;Canada;Hungary;Italy;Mexico;Spain
1129NCT00721123
(ClinicalTrials.gov)
August 200522/7/2008A Long-term Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients With Rheumatoid ArthritisLong-term Extension Study of Safety During Treatment With Tocilizumab (MRA) in Patients Completing Treatment in WA17822Rheumatoid ArthritisDrug: TocilizumabHoffmann-La RocheNULLCompleted18 YearsN/AAll538Phase 3Argentina;Australia;Austria;Brazil;Bulgaria;Canada;France;Germany;Hong Kong;Hungary;Israel;Italy;Mexico;Singapore;Slovakia;Switzerland;Thailand;China
1130NCT00243412
(ClinicalTrials.gov)
August 200521/10/2005A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving MethotrexateA Double-Blind, Randomized, Multicenter, Phase II Study of the Safety and Efficacy of Two Rituximab Regimens in Subjects With Moderate to Severe Active Rheumatoid Arthritis Receiving Stable Doses of MethotrexateRheumatoid ArthritisDrug: folate;Drug: methotrexate;Drug: methylprednisolone;Drug: Placebo;Drug: RituximabGenentech, Inc.NULLCompleted18 Years65 YearsAll42Phase 2United States
1131NCT00508768
(ClinicalTrials.gov)
August 200527/7/2007A Study of Oral SCIO-469 Pharmacokinetics (Study of a Drug in the Body to Watch How the Drug is Absorbed, Distributed, Metabolized and Eliminated Over a Period of Time) in the Body of Female Patients With Active Rheumatoid ArthritisA Randomized, Double-Blind, Parallel-Group, Pharmacokinetic Study of Oral SCIO-469 (90 mg qd and 30 mg Tid) in Female Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Oral SCIO-469 capsuleScios, Inc.NULLCompleted18 YearsN/AFemale16Phase 1NULL
1132NCT00122382
(ClinicalTrials.gov)
July 200519/7/2005Remission and Joint Damage Progression in Early Rheumatoid ArthritisA Phase IIIB Multi-center, Randomized, Double-Blind Study to Evaluate Remission and Joint Damage Progression in Methotrexate Naive Early Erosive RA Subjects Treated With Abatacept Plus Methotrexate Compared With MethotrexateRheumatoid ArthritisDrug: Abatacept;Drug: placebo;Drug: methotrexateBristol-Myers SquibbNULLCompleted18 YearsN/AAll1052Phase 3United States;Australia;Belgium;Brazil;Canada;Czech Republic;France;Germany;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Puerto Rico;Russian Federation;South Africa;Spain;United Kingdom;Austria;Ireland
1133NCT00109408
(ClinicalTrials.gov)
July 200527/4/2005A Study to Assess the Safety and Efficacy of Tocilizumab in Patients With Active Rheumatoid ArthritisA Randomized, Double-blind Study of Safety and Reduction in Signs and Symptoms During Treatment With Tocilizumab Monotherapy Versus Methotrexate Monotherapy in Patients With Moderate to Severe Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Methotrexate;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/ABoth673Phase 3United States;Argentina;Australia;Canada;China;Denmark;France;Israel;Italy;Lithuania;Mexico;Norway;Peru;Portugal;Serbia;Slovenia;South Africa;Spain;Croatia;Former Serbia and Montenegro
1134NCT00503425
(ClinicalTrials.gov)
June 30, 200517/7/2007A Study of MabThera (Rituximab) in Participants With Rheumatoid Arthritis Who Have Had an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARD) and/or Anti-Tumor Necrosis Factor (Anti-TNF) Therapy.An Open Label Study to Assess the Safety and Effect on Disease Activity of MabThera in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Prior Treatment With DMARDs and/or One Anti-TNF Alpha AgentRheumatoid ArthritisDrug: Rituximab [MabThera/Rituxan]Hoffmann-La RocheNULLCompleted18 YearsN/AAll215Phase 3Israel
1135NCT00134693
(ClinicalTrials.gov)
June 21, 200524/8/2005A Single Dose Of Compound SB-681323 Compared To Prednisolone On A Protein That Is an Indicator For Rheumatoid ArthritisA Randomised, Placebo-controlled, Parallel Group Single Dose Study of SB681323 in Patients With Active RA to Investigate the CRP Dose Response RelationshipArthritis, RheumatoidDrug: Prednisolone;Drug: SB-681323GlaxoSmithKlineNULLCompleted18 YearsN/AAll77Phase 2Australia;France;Germany;Russian Federation;United Kingdom
1136NCT00160602
(ClinicalTrials.gov)
June 20058/9/2005A Study of Liquid Certolizumab Pegol as Additional Medication to Methotrexate in the Treatment of Signs and Symptoms of Rheumatoid Arthritis and in Prevention of Joint Damage in Patients With Active Rheumatoid ArthritisA Phase III Multi-center, Double-blind, Placebo-controlled, Parallel Group 24-Week Study to Assess the Efficacy and Safety of Two Dose Regimens of Liquid Certolizumab Pegol as Additional Medication to Methotrexate in the Treatment of Signs and Symptoms of Rheumatoid Arthritis and in Prevention of Joint Damage in Patients With Active Rheumatoid Arthritis Who Have an Incomplete Response to Methotrexate.Rheumatoid ArthritisDrug: Certolizumab PegolUCB PharmaNULLCompleted18 YearsN/AAll590Phase 3United States;Bulgaria;Chile;Croatia;Czechia;Estonia;Israel;Latvia;Lithuania;Mexico;Poland;Russian Federation;Serbia;Slovakia;Ukraine;Czech Republic;Former Serbia and Montenegro
1137NCT00233558
(ClinicalTrials.gov)
June 200513/9/2005Open-Label Steroid Reduction Study of Adalimumab With Methotrexate in Patients With Active Rheumatoid ArthritisMulticentre, Randomised, Open Label Study Comparing a Scheduled Steroid Reduction Strategy” Versus a Free Steroid Reduction Strategy (Physician’s Usual Practice for Reducing Steroids) in Patients With Active RA Treated With Humira 40 mg Eow + MTX During 9 MonthsRheumatoid ArthritisDrug: adalimumab (up to 9 months exposure);Drug: methotrexateAbbottNULLTerminated18 YearsN/ABoth160Phase 4United States
1138NCT00205478
(ClinicalTrials.gov)
June 200512/9/2005Phase 2 Clinical Study in Rheumatoid Arthritis With an Investigational Oral p38 MAP Kinase Inhibitor VX-702A 12-Week, Double-Blind, Randomized, Parallel Group, Placebo Controlled Study of Two Doses of VX-702 in Subjects With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: VX-702Vertex Pharmaceuticals IncorporatedNULLCompleted18 Years75 YearsBoth300Phase 2Bulgaria;Croatia;Czech Republic;Former Serbia and Montenegro;Poland;Russian Federation;Slovakia;Slovenia;Ukraine
1139NCT00113308
(ClinicalTrials.gov)
June 20057/6/2005COX-2 Inhibitor Study In Patients With Rheumatoid ArthritisA Phase III, 12-Week, Multicentre, Double-Blind, Randomised, Placebo- and Active Comparator-Controlled, Parallel Group Study to Investigate the Efficacy and Safety of GW406381, 5mg, 10mg, 25mg, and 50mg Administered Orally Once Daily, in Adults With Rheumatoid ArthritisArthritis, RheumatoidDrug: GW406381GlaxoSmithKlineNULLCompleted18 YearsN/AAll2208Phase 3United States;Argentina;Austria;Belgium;Bulgaria;Canada;Chile;Costa Rica;Denmark;Finland;France;Germany;Greece;Hungary;India;Ireland;Italy;Korea, Republic of;Latvia;Mexico;Netherlands;New Zealand;Norway;Peru;Philippines;Poland;Puerto Rico;Romania;Russian Federation;South Africa;Spain;Ukraine;United Kingdom;Czech Republic;Estonia;Lithuania;Pakistan;Slovakia;Taiwan
1140NCT00688103
(ClinicalTrials.gov)
June 200525/5/2008Efficacy and Safety of Etanercept in Active RA Despite Methotrexate Therapy in JapanEfficacy and Safety of Etanercept in Active Rheumatoid Arthritis Despite Methotrexate Therapy in JapanRheumatoid ArthritisDrug: ETN Alone;Drug: ETN+MTXJapan Biological Agent Study Integrated ConsortiumNULLCompleted18 YearsN/AAll151Phase 4Japan
1141NCT01270087
(ClinicalTrials.gov)
May 20054/1/2011The Effect of Adalimumab (Humira) on Vascular Abnormalities in Rheumatoid Arthritis. A Pilot Study.The Effect of Adalimumab (Humira) on Vascular Abnormalities in Rheumatoid Arthritis. A Pilot Study.Rheumatoid ArthritisDrug: AdalimumabSkåne University HospitalAbbott;The Swedish Research Council;The Swedish Rheumatism Ass;Crafoord FoundationCompleted18 YearsN/ABoth14Phase 4Sweden
1142NCT00419809
(ClinicalTrials.gov)
May 20055/1/2007SB-681323-Methotrexate Interaction StudyA Placebo Controlled Study to Evaluate the Safety and Tolerability of Repeat Doses of SB-681323 in Patients Receiving Methotrexate for Rheumatoid Arthritis.Arthritis, RheumatoidDrug: SB-681323 oral tabletsGlaxoSmithKlineNULLCompleted18 Years75 YearsBoth18Phase 1Australia
1143NCT00432484
(ClinicalTrials.gov)
May 20056/2/2007Lingzhi and Sen Miao San for the Treatment of Rheumatoid ArthritisLingzhi (Ganoderma Lucidum) and Sen Miao San Supplementation in Rheumatoid Arthritis(RA): An Animal Model and A Phase I StudyRheumatoid ArthritisDrug: Lingzhi and Sen Miao SanChinese University of Hong KongNULLCompleted18 YearsN/ABoth70Phase 2China
1144NCT00106522
(ClinicalTrials.gov)
May 200525/3/2005A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis Currently on Methotrexate TherapyA Randomized, Double-blind Study of Safety and Reduction in Signs and Symptoms During Treatment With Tocilizumab Versus Placebo, in Combination With Methotrexate, in Patients With Moderate to Severe Active Rheumatoid Arthritis and Inadequate Response to Anti-TNF TherapyRheumatoid ArthritisDrug: Methotrexate;Drug: Placebo;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/ABoth499Phase 3United States;Australia;Belgium;Canada;France;Germany;Iceland;Italy;Mexico;Netherlands;Puerto Rico;Sweden;Switzerland;United Kingdom
1145NCT00115219
(ClinicalTrials.gov)
May 200521/6/2005Evaluating Efficacy and Safety of Etanercept 50 mg Twice Weekly (BIW) in Rheumatoid Arthritis (RA) Subjects Who Are Sub-Optimal Responders to Etanercept 50 mg Once Weekly (QW)A Multi-center, Randomized, Double-Blind, Active-Controlled Study Evaluating Efficacy and Safety of Etanercept 50 mg Twice Weekly (BIW) in Rheumatoid Arthritis Subjects Who Are Sub-optimal Responders to Etanercept 50 mg Once Weekly (QW)Rheumatoid ArthritisDrug: EtanerceptAmgenNULLCompleted18 YearsN/ABoth200Phase 4United States
1146NCT00106574
(ClinicalTrials.gov)
April 200525/3/2005A Study to Assess the Effect of Tocilizumab + DMARD Therapy on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid ArthritisA Randomized, Double-blind Study of the Effect of Tocilizumab on Reduction in Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis and Inadequate Response to DMARD TherapyRheumatoid ArthritisDrug: Placebo;Drug: tocilizumab [RoActemra/Actemra]Hoffmann-La RocheNULLCompleted18 YearsN/ABoth1220Phase 3United States;Argentina;Australia;Brazil;Canada;China;Costa Rica;Czech Republic;Finland;France;Germany;Hong Kong;Mexico;Panama;Russian Federation;South Africa;Spain;Sweden;Thailand
1147NCT00124982
(ClinicalTrials.gov)
April 200530/6/2005Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF TherapyA Phase III, Multi-Center, Open Label Study to Evaluate the Efficacy, Tolerability and Safety of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-Biologic DMARDs Who Have an Inadequate Response to Anti-TNF Therapy and Have Limited Therapeutic OptionsRheumatoid ArthritisDrug: Abatacept;Drug: Non-biologic Disease Modifying Anti-Rheumatic Drug (DMARD);Drug: Anti-Tumor Necrosing Factor (TNF) TherapyBristol-Myers SquibbNULLCompleted18 YearsN/AAll1286Phase 3United States;Belgium;Czech Republic;France;Germany;Ireland;Italy;Mexico;Spain;United Kingdom;Canada
1148NCT01745055
(ClinicalTrials.gov)
April 20054/12/2012Co-Administration Of Methotrexate And CP-690,550A Phase 1, Open Label Study Of The Pharmacokinetics Of Multiple Doses Of Oral CP-690,550 And Single Doses Of Oral Methotrexate In Rheumatoid Arthritis SubjectsRheumatoid ArthritisDrug: CP-690,550 (tofacitinib);Drug: Methotrexate (MTX)PfizerNULLCompleted18 Years70 YearsAll12Phase 1United States
1149NCT00503503
(ClinicalTrials.gov)
March 200516/7/2007Study Evaluating the Efficacy of Enbrel (Etanercept) in Subjects in JapanSafety and Efficacy From Large Scale All Cases Surveillance for Etanercept in JapanRheumatoid ArthritisDrug: Enbrel (etanercept)Wyeth is now a wholly owned subsidiary of PfizerNULLCompleted11 Years90 YearsBothNULL
1150NCT00144586
(ClinicalTrials.gov)
March 20052/9/2005Long-term Treatment Study of MRA for Rheumatoid Arthritis (RA) From Study MRA220JP or MRA221JPAn Open-label, Extension, Phase III Study to Evaluate the Long-term Safety and Efficacy of MRA in Patients With RA Who Participated in Study MRA220JP or MRA221JPRheumatoid ArthritisDrug: MRA(Tocilizumab)Chugai PharmaceuticalNULLCompleted20 Years75 YearsBoth42Phase 3NULL
1151NCT00124449
(ClinicalTrials.gov)
February 200530/6/2005Study of Abatacept Versus Placebo to Assess the Prevention of Rheumatoid Arthritis (RA) in Adult PatientsA Phase II Study of Abatacept Versus Placebo to Assess the Prevention of Rheumatoid Arthritis (RA) in Adult Patients With Undifferentiated Arthritis Who Are at High Risk for the Development of RAArthritis, RheumatoidDrug: Abatacept;Drug: placeboBristol-Myers SquibbNULLCompleted18 Years75 YearsAll56Phase 2United States;Australia;Belgium;France;Germany;Italy;Mexico;Puerto Rico;Spain;United Kingdom
1152NCT00095147
(ClinicalTrials.gov)
February 20051/11/2004Abatacept and Infliximab in Combination With Methotrexate in Subjects With Rheumatoid ArthritisA Phase IIIB, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Comparative Study of Abatacept or Infliximab in Combination With Methotrexate in Controlling Disease Activity in Subjects With Rheumatoid Arthritis Having an Inadequate Clinical Response to MethotrexateRheumatoid ArthritisDrug: Abatacept (ABA) + Methotrexate (MTX), double-blind (DB);Drug: Infliximab (INF) + MTX, DB;Drug: Placebo (PLA) + MTX, DB;Drug: PLA + MTX switched to ABA+ MTX, DB;Drug: ABA, open-label (OL)Bristol-Myers SquibbNULLCompleted18 Years75 YearsAll431Phase 3United States;Argentina;Australia;Brazil;Canada;Czech Republic;Denmark;Korea, Republic of;Mexico;Peru;Poland;Puerto Rico;Russian Federation;South Africa;Spain;Sweden;Switzerland
1153NCT00291928
(ClinicalTrials.gov)
February 200514/2/2006HuMax-CD20 in Active Rheumatoid Arthritis, Phase I/IIA Double-blind, Randomized, Placebo Controlled, Dose Escalation, Multi-centerphase I/II Trial of HuMax-CD20, a Fully Human Monoclonal Anti-CD20antibody, in Patients With Active Rheumatoid Arthritis Who Have Previously Failedone or More Disease Modifying Anti-rheumatic DrugsArthritis, RheumatoidDrug: Part A;Drug: Part BGlaxoSmithKlineNULLCompleted18 YearsN/ABoth201Phase 2United States;Denmark;Finland;France;Hungary;Poland;United Kingdom
1154NCT00152386
(ClinicalTrials.gov)
February 20057/9/2005A Placebo Controlled Study to Assess Efficacy and Safety of Certolizumab Pegol in the Treatment of Rheumatoid ArthritisA Phase III Multicentre, Double Blind, Placebo-controlled, Parallel Group 52-week Study to Assess the Efficacy and Safety of 2 Dose Regimens of Lyophilised CDP870 as Additional Medication to Methotrexate in the Treatment of Signs and Symptoms and Preventing Structural Damage in Patients With Active Rheumatoid Arthritis Who Have an Incomplete Response to MethotrexateRheumatoid ArthritisDrug: Certolizumab pegol (CDP870)UCB PharmaNULLCompleted18 YearsN/AAll950Phase 3Croatia;Czechia;Israel;Latvia;Russian Federation;Ukraine;United States;Czech Republic;Argentina;Australia;Belgium;Bulgaria;Canada;Chile
1155NCT00144560
(ClinicalTrials.gov)
February 20052/9/2005Drug-Drug Interaction Study of MRA in Patient With Rheumatoid Arthritis (RA)An Open-Label, Clinical Pharmacology Study to Investigate Drug-Drug Interaction in Patients With RARheumatoid ArthritisDrug: MRA(Tocilizumab)Chugai PharmaceuticalNULLCompleted20 Years75 YearsBoth31N/ANULL
1156NCT00105976
(ClinicalTrials.gov)
February 200518/3/2005Efficacy Study of MM-093 in Rheumatoid Arthritis Patients on Methotrexate (MTX)A Phase 2, Double-Blind, Parallel, Placebo-Controlled, Randomized Study to Evaluate the Efficacy and Safety of 3 Different Dose Levels (2.5, 7.5 and 20 mg) of MM-093 in Patients With Active Rheumatoid Arthritis on Stable Doses of MethotrexateRheumatoid ArthritisDrug: MM-093Merrimack PharmaceuticalsNULLCompleted18 Years80 YearsBoth260Phase 2United States
1157NCT00132769
(ClinicalTrials.gov)
January 20052/8/2005A Study of a Novel Investigational Drug in Rheumatoid Arthritis Patients (MK-0873-012)(COMPLETED)A Randomized, Placebo-Controlled, Parallel-Group, Double-Blind, 12-Week Study to Assess the Clinical Efficacy, Safety, and Tolerability of MK-0873 in Rheumatoid ArthritisRheumatoid ArthritisDrug: MK-0873;Drug: Comparator: PlaceboMerck Sharp & Dohme Corp.NULLCompleted18 Years65 YearsAll106Phase 2Belgium;Canada;Czech Republic;Finland;Germany;Italy;Norway;Spain;Switzerland
1158NCT00246168
(ClinicalTrials.gov)
January 200528/10/2005ULTRACET (Tramadol Hydrochloride and Acetaminophen) for the Treatment of Rheumatoid Arthritis Pain.ULTRACET (Tramadol Hydrochloride and Acetaminophen) add-on Therapy for the Treatment of the Pain of Rheumatoid Arthritis: A Randomized, Double-blind, Placebo-controlled StudyArthritis, RheumatoidDrug: tramadol hydrochloride + acetaminophenJanssen Korea, Ltd., KoreaNULLCompleted18 Years79 YearsBoth277Phase 4NULL
1159NCT00123149
(ClinicalTrials.gov)
January 200519/7/2005Open-Label Extension Safety Study of PROCRIT in Patients With Anemia of Chronic Disease Due to Rheumatoid ArthritisAn Open-Label (OL) Extension Study to Assess Safety of PROCRIT (Epoetin Alfa) in Patients With Anemia of Chronic Disease (ACD) Due to Rheumatoid Arthritis (RA)Anemia;Rheumatoid ArthritisDrug: Epoetin alfaOrtho Biotech Products, L.P.NULLWithdrawn18 Years99 YearsBoth0Phase 2NULL
1160NCT00147498
(ClinicalTrials.gov)
January 20052/9/2005Three Dose Levels of CP-690,550 Monotherapy Versus Placebo, Administered Orally Twice Daily (BID) for 6 WeeksA Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Compare 3 Dose Levels Of CP-690,550 Versus Placebo, Administered Orally Twice Daily (BID) For 6 Weeks, In The Treatment Of The Signs And Symptoms Of Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: CP-690,550;Other: PlaceboPfizerNULLCompleted18 Years70 YearsAll264Phase 2United States;Belgium;Brazil;Canada;Germany;Italy;Mexico;Slovakia;Spain;Austria
1161NCT00583557
(ClinicalTrials.gov)
January 200520/12/2007A Continuation Trial for Subjects With Rheumatoid Arthritis That Have Completed Protocol LBRA01A Multi-Center, Open-Label, Continuation Trial of LymphoStat-B™ Antibody (Monoclonal Anti-BLyS Antibody) in Subjects With Rheumatoid Arthritis (RA) Who Completed the Phase 2 Protocol LBRA01Rheumatoid ArthritisDrug: belimumabHuman Genome Sciences Inc.NULLTerminated18 YearsN/AAll155Phase 2United States;Poland
1162NCT00144573
(ClinicalTrials.gov)
January 20052/9/2005Clinical Pharmacology Study of MRA in Patient With Rheumatoid Arthritis (RA) With Renal ImpairmentAn Open-Label, Clinical Pharmacology Study to Evaluate the Safety and PK of MRA in Patients With RA With Renal ImpairmentRheumatoid ArthritisDrug: MRA(Tocilizumab)Chugai PharmaceuticalNULLCompleted20 Years75 YearsBoth14N/ANULL
1163NCT00106535
(ClinicalTrials.gov)
January 200525/3/2005A Study to Assess the Effect of Tocilizumab + Methotrexate on Prevention of Structural Joint Damage in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA)A Randomized, Double-blind Study of Safety and Prevention of Structural Joint Damage During Treatment With Tocilizumab Versus Placebo, in Combination With Methotrexate, in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: Placebo;Drug: MethotrexateHoffmann-La RocheNULLCompleted18 YearsN/AAll1196Phase 3United States;Australia;Brazil;China;Denmark;Finland;France;Greece;Italy;Mexico;Norway;Poland;Puerto Rico;South Africa;Spain;Switzerland
1164NCT00365001
(ClinicalTrials.gov)
January 200515/8/2006A Drug Interaction Study Between Tocilizumab, Methotrexate and Simvastatin on Patients With Rheumatoid Arthritis.A Randomized, Open-label Study to Assess the Pharmacokinetics of Simvastatin and Methotrexate in Combination With Tocilizumab in Patients With Rheumatoid Arthritis.Rheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: Methotrexate;Drug: SimvastatinHoffmann-La RocheNULLCompleted18 Years75 YearsBoth23Phase 1United States;New Zealand
1165NCT00106548
(ClinicalTrials.gov)
January 200525/3/2005A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid ArthritisA Randomized, Double-blind Study of Safety and Reduction in Signs and Symptoms During Treatment With Tocilizumab Versus Placebo, in Combination With Methotrexate, in Patients With Moderate to Severe Rheumatoid ArthritisRheumatoid ArthritisDrug: tocilizumab [RoActemra/Actemra];Drug: Placebo;Drug: MethotrexateHoffmann-La RocheNULLCompleted18 YearsN/ABoth623Phase 3Argentina;Australia;Austria;Brazil;Bulgaria;Canada;China;France;Germany;Hungary;Israel;Italy;Mexico;Singapore;Slovakia;Switzerland;Thailand;Spain
1166NCT00236028
(ClinicalTrials.gov)
November 20047/10/2005A Safety and Efficacy Study for Infliximab (Remicade) With Methotrexate in Patients With Early Rheumatoid ArthritisA Randomized, Double-blind, Trial of Anti-TNFa Chimeric Monoclonal Antibody (Infliximab) in Combination With Methotrexate Compared With Methotrexate Alone for the Treatment of Patients With Early Rheumatoid ArthritisRheumatoid ArthritisDrug: InfliximabCentocor, Inc.NULLCompleted18 Years75 YearsBoth607Phase 3NULL
1167NCT00379600
(ClinicalTrials.gov)
November 200421/9/2006The Anti-Inflammatory And Metabolic Effects Of Rosiglitazone In Subjects With Rheumatoid ArthritisA Randomised, Double-blind, Placebo-controlled, Parallel Group Study to Investigate the Anti-inflammatory and Metabolic Effects of Rosiglitazone XR, 8mg Once Daily, in Subjects With Rheumatoid ArthritisArthritis, RheumatoidDrug: rosiglitazone XRGlaxoSmithKlineNULLCompleted18 YearsN/ABoth96Phase 2Lithuania;United Kingdom
1168NCT00854321
(ClinicalTrials.gov)
November 20042/3/2009Patients With Rheumatoid Arthritis (RA) Treated With Rituximab in Kuopio University HospitalOne Centre Follow-up Study on Safety and EfficacyRheumatoid ArthritisDrug: rituximab;Drug: rituximab, observational study amon patients with active RAKuopio University HospitalNULLCompleted18 YearsN/ABoth49N/AFinland
1169NCT01600521
(ClinicalTrials.gov)
November 20045/4/2012A Clinical Study of a Natural Remedy for Rheumatoid Arthritis vs. Commonly Used Conventional MedicationsA Clinical Study of a Natural Remedy for Rheumatoid Arthritis vs. Commonly Used Conventional MedicationsRheumatoid ArthritisDrug: A Natural Remedy for Rheumatoid Arthritis vs. Common DrugsUniversity of Minnesota - Clinical and Translational Science InstituteNULLCompleted18 YearsN/ABoth1748N/AChina
1170NCT00170872
(ClinicalTrials.gov)
November 20049/9/20056 Week Open-label Trial With Lumiracoxib 200mg o.d. in Primary Knee Osteoarthritis or Rheumatoid ArthritisA 6 Week, Multicenter, Open-label Trial to Evaluate the Safety, Tolerability and Efficacy of Lumiracoxib 200mg o.d. in Patients With Primary Knee Osteoarthritis or Rheumatoid ArthritisOsteoarthritis;Rheumatoid ArthritisDrug: LumiracoxibNovartisNULLCompleted18 YearsN/ABoth135Phase 3NULL
1171NCT00195494
(ClinicalTrials.gov)
November 200413/9/2005Study Comparing Etanercept and Methotrexate vs. Methotrexate Alone in Rheumatoid ArthritisA 24-Month,Randomized,Double-Blind,Two-Period Study to Evaluate the Efficacy and Safety of the Combination of Etanercept and Methotrexate and Methotrexate Alone in Subjects With Early Rheumatoid ArthritisRheumatoid ArthritisDrug: Etanercept;Drug: Methotrexate;Drug: PlaceboWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/AAll542Phase 4United States
1172NCT00747214
(ClinicalTrials.gov)
November 20043/9/2008A Study Comparing CRx-102 Plus Disease-modifying Anti-rheumatic Drug (DMARD) Therapy to Placebo Plus DMARD Therapy in RAA Multicenter, Randomized, Blinded Study Comparing the Effect of CRx-102 Plus DMARD Therapy to That of Placebo Plus DMARD Therapy on Serum C Reactive Protein (CRP) and Cytokines in Subjects With RARheumatoid ArthritisDrug: CRx-102;Drug: Placebo;Drug: DMARD TherapyZalicusNULLCompleted18 YearsN/AAll59Phase 2NULL
1173NCT00094341
(ClinicalTrials.gov)
October 200416/10/2004Preference of Rheumatoid Arthritis (RA) Patients of Enbrel® (Etanercept) Auto-Injector Versus Enbrel® Pre-Filled SyringesAn Open-Label, Randomized, Crossover Study to Assess Preference of Rheumatoid Arthritis (RA) Patients of Enbrel® (Etanercept) Auto-Injector Versus Enbrel® Pre-Filled SyringesRheumatoid ArthritisDrug: EtanerceptAmgenNULLCompleted18 YearsN/ABoth215Phase 4United States
1174NCT00831649
(ClinicalTrials.gov)
September 200427/1/2009A Phase II, Multicenter, Open-Label, Long-Term Study of the Safety, Tolerability, and Efficacy of Intravenous Natalizumab in Subjects With Rheumatoid Arthritis Who Have Previously Participated in Study ELN100226-RA201A Phase II, Multicenter, Open-Label, Long-Term Study of the Safety, Tolerability, and Efficacy of Intravenous Natalizumab in Subjects With Rheumatoid Arthritis Who Have Previously Participated in Study ELN100226-RA201Rheumatoid ArthritisDrug: natalizumabBiogenElan PharmaceuticalsTerminated18 Years75 YearsBothPhase 2NULL
1175NCT00117091
(ClinicalTrials.gov)
September 200430/6/2005Anakinra (Kineret®) in Combination With Disease Modifying Anti-Rheumatic Drugs (DMARDS) in Subjects With Active Rheumatoid Arthritis (RA)An Open-Label Multicentre Study of Anakinra (Kineret®) in Combination With DMARDS in Subjects With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Anakinra (Kineret®)AmgenNULLCompleted18 YearsN/ABothPhase 3NULL
1176NCT00412256
(ClinicalTrials.gov)
September 200415/12/2006Omegaven in Patients With Rheumatoid Arthritis (ORA-Trial)Clinical Trial to Evaluate the Effect of Parenteral Supplementation With Omega-3-Fatty Acids in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Omegaven (10% fish-oil emulsion; Fresenius-Kabi)Humanis Klinikum NiederosterreichNULLCompleted18 YearsN/ABoth60Phase 3Austria
1177NCT00831922
(ClinicalTrials.gov)
September 200428/1/2009Efficacy of Oral AB1010 in Adult Patients With Active Rheumatoid ArthritisA Multicenter, Open Label, Randomized, Parallel-group Study to Evaluate the Efficacy of Oral AB1010 in Adult Patients With Active Rheumatoid Arthritis With Inadequate Response to at Least One Disease Modifying Anti Rheumatic Drugs (DMARD)Rheumatoid ArthritisDrug: masitinib (AB1010)AB ScienceNULLCompleted18 YearsN/AAll43Phase 2NULL
1178NCT00146640
(ClinicalTrials.gov)
August 31, 20046/9/2005Prednisone Timed-Release Tablet (TRT) Study: Modified-Release (MR) Formulation of Prednisone Compared to Standard Immediate-Release (IR) Prednisone in Participants With Rheumatoid ArthritisA New Timed-Release Tablet Formulation of Prednisone Compared to Standard Prednisone in Patients With Rheumatoid Arthritis- A Randomized, Multi-Centre, Double-Blind, Active Controlled Study With Open Extension on the New Drug OnlyRheumatoid ArthritisDrug: MR Prednisone;Drug: IR Prednisone;Drug: Placebo - MR Prednisone;Drug: Placebo - IR PrednisoneMerck KGaA, Darmstadt, GermanyNULLCompleted18 Years80 YearsAll288Phase 3Germany;Poland
1179NCT00760864
(ClinicalTrials.gov)
August 200424/9/2008Safety and Efficacy of TAK-715 in Subjects With Rheumatoid ArthritisA Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Efficacy of Oral TAK-715 in the Treatment of the Signs and Symptoms of Rheumatoid ArthritisArthritis, RheumatoidDrug: TAK-715 and methotrexate;Drug: MethotrexateTakedaNULLCompleted18 YearsN/ABoth432Phase 2NULL
1180NCT00095498
(ClinicalTrials.gov)
August 20045/11/2004Efficacy, Safety and Tolerability of Denosumab in the Treatment of Rheumatoid ArthritisA Randomized, Double-blind, Placebo-controlled, Multi-dose Phase 2 Study to Determine the Efficacy, Safety and Tolerability of Denosumab in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: placebo;Drug: denosumabAmgenNULLCompleted18 YearsN/AAll227Phase 2United States
1181NCT00696059
(ClinicalTrials.gov)
August 20049/6/2008Humira in Rheumatoid Arthritis - Do Bone Erosions Heal?Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging.Rheumatoid Arthritis;Arthritis;Joint DiseasesDrug: Adalimumab (Humira)Hvidovre University HospitalAbbottCompleted18 Years90 YearsBoth52Phase 4Denmark
1182NCT00234897
(ClinicalTrials.gov)
August 200413/9/2005Efficacy of HUMIRA in Subjects With Active Rheumatoid ArthritisHumira Efficacy Response Optimization Study in Subjects With Active Rheumatoid Arthritis (HERO)Rheumatoid ArthritisDrug: adalimumabAbbottNULLCompleted18 YearsN/ABoth1938Phase 4United States
1183NCT00279734
(ClinicalTrials.gov)
August 200419/1/2006Vaccination Study of Abatacept (BMS-188667) for Normal Healthy VolunteersAn Exploratory Study to Evaluate the Effect of Abatacept (BMS-188667) on the Antibody Response Following Tetanus Toxoid and 23-Valent Pneumococcal Vaccinations in Healthy SubjectsRheumatoid ArthritisDrug: Tetanus + pnemococcal vaccines alone;Drug: Abatacept + vaccines;Drug: Abatacept + VaccinesBristol-Myers SquibbNULLCompleted18 Years65 YearsBoth80Phase 1United States
1184NCT00239382
(ClinicalTrials.gov)
July 1, 200413/10/2005A Study to Compare Meloxicam IM Once Daily Versus Meloxicam Orally Once Daily in Patients With Rheumatoid ArthritisA Randomized, Open-labelled Study to Compare the Efficacy and Safety of Meloxicam 15 mg IM Ampoules Once Daily and Meloxicam 15 mg Tablets Administered Orally Once Daily Over a Period of 7 Days in Patients With RA.Arthritis, RheumatoidDrug: Meloxicam ampoule;Drug: Meloxicam tabletBoehringer IngelheimNULLCompleted18 YearsN/AAll150Phase 3China
1185NCT00506896
(ClinicalTrials.gov)
July 200420/7/2007Monoarticular Corticosteroid Injection Versus Systemic Administration in the Treatment of Rheumatoid Arthritis PatientsMonoarticular Corticosteroid Injection Versus Systemic Administration in the Treatment of Rheumatoid Arthritis Patients: A Randomized Double-Blind Controlled StudyRheumatoid ArthritisDrug: intraarticular injectionFederal University of São PauloNULLCompleted18 Years65 YearsBoth60Phase 2Brazil
1186NCT00236678
(ClinicalTrials.gov)
July 20047/10/2005Randomized, Double-blind, Placebo-controlled Study to Assess Fatigue in Patients With ACD Due to RA Receiving PROCRITA Randomized, Double-blind, Placebo-controlled Study to Assess Fatigue in Patients With Anemia of Chronic Disease (ACD) Due to Rheumatoid Arthritis Receiving PROCRIT? (Epoetin Alfa)Anemia;Rheumatoid ArthritisDrug: Epoetin alfaJohnson & Johnson Pharmaceutical Research & Development, L.L.C.Ortho Biotech Products, L.P.Terminated18 YearsN/ABoth29Phase 2NULL
1187NCT00089921
(ClinicalTrials.gov)
July 200417/8/2004SPRiNG: SCIO-469 Patients With Rheumatoid Arthritis Not Receiving MethotrexateA 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy of Oral SCIO-469 in Subjects With Active Rheumatoid Arthritis Who Are Not Receiving DMARDs Other Than HydroxychloroquineArthritis, RheumatoidDrug: SCIO-469;Drug: PlaceboScios, Inc.NULLCompleted18 YearsN/ABoth302Phase 2United States
1188NCT00154336
(ClinicalTrials.gov)
July 20048/9/2005A Study of Imatinib 400 mg Once Daily in Combination With Methotrexate in the Treatment of Rheumatoid Arthritis.3-Month, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy, Safety & Tolerability of Imatinib 400 mg Daily in Combination With Methotrexate (MTX)Compared to MTX Alone in the Treatment of Rheumatoid Arthritis (RA).Rheumatoid ArthritisDrug: Imatinib;Drug: Methotrexate;Drug: Imatinib PlaceboNovartis PharmaceuticalsNULLCompleted18 Years75 YearsAll50Phase 2Austria;Canada;Finland;United Kingdom
1189NCT00094562
(ClinicalTrials.gov)
June 200420/10/2004A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight LossAAFA™ Fish Oil Nutritional Supplementation to Maintain Body Weight in Patients With Disease-Related Weight LossCancer;Cancer Cachexia;Chronic Obstructive Pulmonary Disease;Chronic Heart Failure;Rheumatoid ArthritisDrug: Fish oil supplementSidney Kimmel Comprehensive Cancer Center at Johns HopkinsNational Center for Complementary and Integrative Health (NCCIH)Completed18 Years90 YearsAll25Phase 2United States
1190NCT00244153
(ClinicalTrials.gov)
June 200425/10/2005Intraarticular Opioids Vs Glucocorticosteroids in GonarthritisIntraarticular Application of Opioids Versus Glucocorticosteroids Versus Placebo in Rheumatoid ArthritisRheumatic DiseaseDrug: intraarticular morphine;Drug: intraarticular dexamethasoneCharite University, Berlin, GermanyNULLRecruiting19 YearsN/ABoth120Phase 1/Phase 2Germany
1191NCT02097745
(ClinicalTrials.gov)
June 200420/3/2014A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa TherapiesAn Open Label Study of the Efficacy and Safety of Re-treatments With Rituximab (MabThera/Rituxan) in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNFa TherapiesRheumatoid ArthritisDrug: methotrexate;Drug: rituximab [MabThera/Rituxan]Hoffmann-La RocheBiogenCompleted18 Years80 YearsAll341Phase 3United States;Belgium;Canada;France;Germany;Ireland;Israel;Italy;Netherlands;Norway;United Kingdom
1192NCT00252668
(ClinicalTrials.gov)
June 20049/11/2005Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis SubjectsAn Open-Label, Multicentre, Extension Study of the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis SubjectsRheumatoid ArthritisDrug: Etanercept;Drug: MethotrexateWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/ABoth300Phase 4NULL
1193NCT00144534
(ClinicalTrials.gov)
June 20042/9/2005Long-term Treatment Study of MRA for Rheumatoid Arthritis (RA) From Study MRA213JPAn Open-label, Extension, Phase III Study to Evaluate the Long-term Safety and Efficacy of MRA in Patients With RA Who Participated in Study MRA213JPRheumatoid ArthritisDrug: MRA (Tocilizumab)Chugai PharmaceuticalNULLCompleted20 Years75 YearsBoth115Phase 3NULL
1194NCT00542022
(ClinicalTrials.gov)
June 20045/10/2007Efficacy, Tolerability and Safety Study in Rheumatoid Arthritis (0812-008)A Placebo-Controlled, Parallel-Group, Double-Blind, 12-Week Study to Assess the Clinical Efficacy, Safety, and Tolerability of MK0812 in Rheumatoid Arthritis PatientsArthritis, RheumatoidDrug: MK0812 / Duration of Treatment: 12 Weeks;Drug: Comparator: placebo (unspecified) / Duration of Treatment: 12 WeeksMerck Sharp & Dohme Corp.NULLCompleted18 Years65 YearsBoth149Phase 2NULL
1195NCT00273533
(ClinicalTrials.gov)
June 20046/1/2006Ramipril in Rheumatoid ArthritisEffects of Ramipril on Endothelial Function in Patients With Rheumatoid ArthritisArthritis, RheumatoidDrug: RamiprilUniversity of ZurichSanofiCompleted18 Years60 YearsBoth13Phase 2/Phase 3Switzerland
1196NCT00259610
(ClinicalTrials.gov)
May 200428/11/2005Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)Rheumatoid ArthritisDrug: methotrexate;Drug: sulfasalazine;Drug: hydroxychloroquine;Drug: etanerceptUniversity of Alabama at BirminghamAmgen;Barr Laboratories;PfizerCompleted18 YearsN/AAll755Phase 4United States
1197NCT00195403
(ClinicalTrials.gov)
May 200412/9/2005A Drug Use Investigation of ENBREL for Post-marketing Surveillance (PMS) for RA and PsAA Drug Use Investigation of Enbrel for Post-Marketing SurveillanceRheumatoid ArthritisDrug: EtanerceptPfizerNULLCompleted4 YearsN/AAll1014N/AKorea, Republic of
1198NCT00195338
(ClinicalTrials.gov)
May 200412/9/2005Study Evaluating Enbrel In Adults With Active Rheumatoid Arthritis In LuxemburgA Post-Marketing Surveillance Looking At Safety And Adherence To Treatment Of Enbrel In Adults With Active Rheumatoid Arthritis In LuxemburgRheumatoid ArthritisDrug: etanerceptPfizerInnovex, IncCompleted17 YearsN/AAll25N/ALuxembourg
1199NCT00083759
(ClinicalTrials.gov)
May 20041/6/2004Natalizumab in the Treatment of Rheumatoid Arthritis in Subjects Receiving MethotrexateA Phase II, Multicenter, Double-blind, Placebo-Controlled Study of the Efficacy, Safety, and Tolerability of Intravenous Natalizumab (300 mg) in Subjects With Moderate to Severe Rheumatoid Arthritis (RA) Receiving Concomitant Treatment With Methotrexate (MTX)Rheumatoid ArthritisDrug: natalizumab;Drug: placeboBiogenElan PharmaceuticalsTerminated18 Years75 YearsAll299Phase 2United States;Canada
1200NCT00099554
(ClinicalTrials.gov)
May 200416/12/2004Effectiveness and Safety of Enbrel® (Etanercept) in Rheumatoid Arthritis Subjects Who Have Failed Remicade® (Infliximab)A Phase 4, Open-Label, Single Arm, Observational Study Evaluating the Effectiveness and Safety of Enbrel® (Etanercept) 50 mg Once Weekly in Rheumatoid Arthritis Subjects Who Have Failed Remicade® (Infliximab)Rheumatoid ArthritisDrug: EtanerceptAmgenNULLCompleted18 YearsN/ABoth200Phase 4United States;Canada
1201NCT00110903
(ClinicalTrials.gov)
May 200416/5/2005Treatment for Subjects With Active Rheumatoid Arthritis (RA)Open-Label Study to Assess the Safety of Etanercept Liquid Administered Once Weekly in Subjects With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Etanercept LiquidAmgenNULLCompleted18 YearsN/ABothPhase 3NULL
1202NCT00291915
(ClinicalTrials.gov)
May 200414/2/2006Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early ArthritisMethotrexate Alone Versus Methotrexate in Combination With Adalimumab in Early ArthritisRheumatoid Arthritis;ArthritisDrug: Adalimumab;Drug: MethotrexateGoupe d'Etudes et de Recherche Clinique En RhumatologieNULLRecruiting18 YearsN/ABoth80Phase 4France
1203NCT00144547
(ClinicalTrials.gov)
April 20042/9/2005Long-term Treatment Study of MRA for Rheumatoid Arthritis (RA) From Study MRA012JPAn Open-label, Extension, Phase III Study to Evaluate the Long-term Safety and Efficacy of MRA in Patients With RA Who Participated in Study MRA012JPRheumatoid ArthritisDrug: MRA(Tocilizumab)Chugai PharmaceuticalNULLCompleted20 YearsN/ABoth241Phase 3NULL
1204NCT00280644
(ClinicalTrials.gov)
April 200419/1/2006Leflunomide in Rheumatoid ArthritisEfficacy of Leflunomide on Joint Inflammation and Destruction of Joint Integrity in Active Rheumatoid Arthritis (RA) PatientsArthritis, RheumatoidDrug: LeflunomideSanofiNULLCompleted18 Years75 YearsBoth60Phase 4Turkey
1205NCT00484809
(ClinicalTrials.gov)
March 20048/6/2007Study Evaluating the Tolerance and Safety of Enbrel (Etanercept) in Adults and ChildrenA Post-Marketing Surveillance Looking at Safety of Enbrel (Etanercept) in Adults With Active Rheumatoid Arthritis (RA) and Children With Juvenile Rheumatoid Arthritis (JRA).Rheumatoid ArthritisDrug: Enbrel (Etanercept)Wyeth is now a wholly owned subsidiary of PfizerNULLCompleted4 YearsN/ABoth100NULL
1206NCT00468377
(ClinicalTrials.gov)
March 200430/4/2007Safety and Efficacy Study of Re-treatment With Rituximab (MabThera/Rituxan) in Patients With Active Rheumatoid Arthritis Who Respond Poorly to Anti-TNFa TherapiesAn Open Label Study of the Efficacy and Safety of Re-treatments With Rituximab (MabThera/Rituxan) in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNFa TherapiesArthritis, RheumatoidDrug: RituximabHoffmann-La RocheGenentech, Inc.Active, not recruiting18 Years80 YearsBoth341Phase 3United States
1207NCT00077870
(ClinicalTrials.gov)
February 200412/2/2004A Study to Evaluate the Safety of Escalating Doses of Ocrelizumab in Subjects With Rheumatoid ArthritisA Randomized, Placebo-Controlled, Multicenter, Blinded Phase I/II Study of the Safety of Escalating Doses of Ocrelizumab (PRO70769) in Subjects With Moderate to Severe Rheumatoid Arthritis Receiving Stable Doses of Concomitant MethotrexateRheumatoid ArthritisDrug: ocrelizumabGenentech, Inc.NULLCompleted18 Years80 YearsBoth237Phase 1/Phase 2United States
1208NCT00367965
(ClinicalTrials.gov)
February 200423/8/2006Study of Eszopiclone Compared to Placebo on Daytime Function in Subjects With Insomnia Related to Rheumatoid ArthritisThe Effect of Eszopiclone 3 mg Compared to Placebo on Daytime Function in Subjects With Insomnia Related to Rheumatoid ArthritisInsomnia;Arthritis, RheumatoidDrug: Eszopiclone;Drug: placeboSunovionNULLCompleted25 Years64 YearsBoth153Phase 3United States
1209NCT00679510
(ClinicalTrials.gov)
February 200415/5/2008Rosuvastatin in Rheumatoid Arthritis (RORA)Phase 2: Effects of Rosuvastatin on Surrogate Markers for Cardiovascular Events in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: rosuvastatin;Drug: placeboUniversity of DundeeNULLCompleted40 YearsN/AAll50Phase 2/Phase 3United Kingdom
1210NCT00224562
(ClinicalTrials.gov)
February 200414/9/2005The RATIO: Registry of Infections and Lymphoma in Patients Treated With TNF-a AntagonistsThe RATIO Registry: French Registry on Opportunistic and Severe Bacterial Infections and Lymphoma in Patients Treated With TNF-a AntagonistsRheumatoid Arthritis;Crohn's Disease;Ankylosing Spondylitis;PsoriasisDrug: TNF-alpha antagonistsAssistance Publique - Hôpitaux de ParisNULLRecruitingN/AN/ABothN/AFrance
1211NCT00144521
(ClinicalTrials.gov)
February 20042/9/2005Comparative Study (Double-Blind) of MRA for Rheumatoid Arthritis (RA)A Double-Blind, Phase III Study to Evaluate the Efficacy and Safety of MRA in Patients With RARheumatoid ArthritisDrug: MRA(Tocilizumab);Drug: MRA placebo;Drug: MTX;Drug: MTX placeboChugai PharmaceuticalNULLCompleted20 Years75 YearsBoth127Phase 3NULL
1212NCT00157872
(ClinicalTrials.gov)
January 7, 20047/9/2005A Study of Rofecoxib Versus Naproxen in the Treatment of Chinese Patient With Rheumatoid Arthritis (0966-231)A Multicenter, Randomized, Parallel-Group, 8-Week, Double-Blind, and Active Comparator-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Rofecoxib Tablet 25 mg Once Daily Versus Naproxen Table 500 mg Twice Daily in the Treatment of Chinese Patient With Rheumatoid ArthritisRheumatoid ArthritisDrug: MK0966; rofecoxib;Drug: Comparator: naproxen tablet 500 mgMerck Sharp & Dohme Corp.NULLCompleted18 YearsN/AAll150Phase 4China
1213NCT00234936
(ClinicalTrials.gov)
December 200316/9/2005Quality of Life Study With Adalimumab in Rheumatoid ArthritisQuality of Life Study With Adalimumab in Rheumatoid ArthritisRheumatoid ArthritisDrug: Adalimumab;Drug: MethotrexateAbbottNULLCompleted18 YearsN/ABoth200Phase 3NULL
1214NCT00095173
(ClinicalTrials.gov)
December 20031/11/2004BMS-188667 in Children and Adolescents With Juvenile Rheumatoid ArthritisA Phase III, Multi-Center, Multi-National, Randomized Withdrawal Study to Evaluate the Safety and Efficacy of BMS-188667 in Children and Adolescents With Active Polyarticular Juvenile Rheumatoid Arthritis (JRA)Juvenile Rheumatoid ArthritisDrug: Abatacept;Drug: PlaceboBristol-Myers SquibbNULLCompleted6 Years17 YearsAll214Phase 3United States;Austria;Brazil;France;Germany;Italy;Mexico;Peru;Portugal;Spain;Switzerland
1215NCT00071812
(ClinicalTrials.gov)
December 200331/10/2003A Safety and Efficacy Study of LymphoStat-B™ (Monoclonal Anti-BLyS Antibody) in Subjects With Rheumatoid Arthritis (RA)A Phase 2, Multi-Center, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety, Tolerability, and Efficacy of LymphoStat-B™ Antibody (Monoclonal Anti-BLyS Antibody) in Subjects With Rheumatoid Arthritis (RA)Arthritis, RheumatoidDrug: Placebo;Drug: Belimumab 1 mg/kg;Drug: Belimumab 4 mg/kg;Drug: Belimumab 10 mg/kgHuman Genome Sciences Inc.NULLCompleted18 Years65 YearsAll283Phase 2United States
1216NCT00076206
(ClinicalTrials.gov)
December 200315/1/2004Study Evaluating CCI-779 in Active Rheumatoid Arthritis on Concomitant Methotrexate TherapyA Double-Blind, Parallel, Placebo-Controlled, Randomized Study to Evaluate the Efficacy and Safety of 3 Different Oral Dose Levels (1, 2, And 4 Mg) of CCI-779 in Subjects With Active Rheumatoid Arthritis on Concomitant Methotrexate TherapyRheumatoid ArthritisDrug: CCI-779;Drug: PlaceboWyeth is now a wholly owned subsidiary of PfizerNULLTerminated18 Years75 YearsBothPhase 2United States
1217NCT00619905
(ClinicalTrials.gov)
December 20038/2/2008Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACZ885 in Patients With Rheumatoid Arthritis With Ongoing Treatment With MethotrexateA Randomized, Double-Blind, Placebo-Controlled, Cohort Dose Escalation Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACZ885 (Anti-Interleukin-1Beta Monoclonal Antibody) in Patients With Active Rheumatoid Arthritis (RA) Despite Ongoing Treatment With Methotrexate (MTX) 15 mg or More Weekly for at Least 3 Months.Rheumatoid ArthritisDrug: ACZ885NovartisNULLCompleted18 Years75 YearsBoth53Phase 1/Phase 2Germany;Netherlands;Switzerland
1218NCT00207714
(ClinicalTrials.gov)
November 200313/9/2005An Efficacy and Safety Study of CNTO 148 Subcutaneous Injection Compared With Placebo in Patients With Active Rheumatoid ArthritisA Randomized, Double-blind, Dose-ranging Trial of CNTO 148 Subcutaneous Injection Compared With Placebo in Subjects With Active Rheumatoid Arthritis Despite Treatment With MethotrexateRheumatoid ArthritisDrug: Golimumab;Drug: MTX;Drug: Placebo;Drug: InfliximabCentocor, Inc.Centocor BVCompleted18 YearsN/AAll172Phase 2NULL
1219NCT00162201
(ClinicalTrials.gov)
October 20039/9/2005An Exploratory Study of Changes in Synovial Immune Responses Following BMS-188667 Therapy in Subjects With Active Rheumatoid Arthritis on Background DMARDs Who Have Failed Anti-TNF TherapyAn Exploratory Study of Changes in Synovial Immune Responses Following BMS-188667 Therapy in Subjects With Active Rheumatoid Arthritis on Background DMARDs Who Have Failed Anti-TNF TherapyRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll16Phase 1United Kingdom
1220NCT00221000
(ClinicalTrials.gov)
August 200313/9/2005Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid ArthritisA Phase II, Multicenter, Randomized, Double-blind, Sham Pheresis-controlled, Study of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis in Patients Who Have an Inadequate Response to Disease Modifying Antirheumatic Drugs and Biological AgentsRheumatoid ArthritisDrug: Methoxsalen;Procedure: Extracorporeal PhotopheresisMallinckrodtNULLCompleted18 YearsN/ABoth86Phase 2United States;Australia;Austria;Belgium;Canada;France;Germany;Italy;Mexico;Slovakia;South Africa
1221NCT00195364
(ClinicalTrials.gov)
July 200313/9/2005Study Evaluating Etanercept in Patients With Rheumatoid Arthritis Who Completed Trial 0881A1-301-EU in SpainLong-Term Safety Study of Etanercept in Patients With Rheumatoid Arthritis Who Completed Trial 0881A1-301-EU in SpainRheumatoid Arthritis;InflammationDrug: EtanerceptWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/ABoth93Spain
1222NCT02184052
(ClinicalTrials.gov)
July 20033/7/2014Safety and Efficacy of Mobic® Ampoules in the Initiation of Treatment of Painful Exacerbations of Osteoarthritis, Rheumatoid Arthritis and Other Similar Painful Inflammatory ConditionsMeloxicam (MOBIC®) Ampoule Post Marketing Surveillance StudyArthritis, RheumatoidDrug: MeloxicamBoehringer IngelheimNULLCompletedN/AN/ABoth121N/ANULL
1223NCT00235859
(ClinicalTrials.gov)
July 20037/10/2005Adalimumab Administered in Korean Rheumatoid Arthritis Subjects Treated With MethotrexateA Randomized, Double-Blind, Placebo-Controlled, Phase III Study of the Human Anti-TNF Antibody Adalimumab Administered as Subcutaneous Injections in Korean Rheumatoid Arthritis Subjects Treated With MethotrexateRheumatoid ArthritisDrug: adalimumab;Drug: methotrexateAbbottEisai LimitedCompleted18 YearsN/ABoth128Phase 3NULL
1224NCT00245934
(ClinicalTrials.gov)
June 200326/10/2005Study Evaluating Enbrel in Patients With Rheumatoid ArthritisObservational Study With Enbrel in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: EnbrelWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/ABoth1500N/ANULL
1225NCT00548834
(ClinicalTrials.gov)
June 200315/10/2007Efficacy and Safety of CDP870 Versus Placebo in the Treatment of the Signs and Symptoms of Rheumatoid ArthritisEfficacy and Safety of CDP870 400 mg Subcutaneously Versus Placebo in the Treatment of the Signs and Symptoms of Patients With Rheumatoid Arthritis Who Have Previously Failed at Least One DMARDRheumatoid ArthritisDrug: CDP870UCB PharmaNULLCompleted18 Years75 YearsBoth220Phase 3NULL
1226NCT00213538
(ClinicalTrials.gov)
June 200313/9/2005Gene Expression Profiling in PBMCs as a Tool for Prediction of Anakinra Responsiveness in Rheumatoid ArthritisGene Expression Profiling in PBMCs as a Tool for Prediction of Anakinra Responsiveness in Rheumatoid ArthritisRheumatoid ArthritisDrug: Response to anakinra associated with methotrexateUniversity Hospital, RouenNULLCompleted18 YearsN/AAll341N/AFrance
1227NCT00074438
(ClinicalTrials.gov)
June 200312/12/2003Study to Assess the Efficacy and Safety of Rituximab in Patients With Rheumatoid ArthritisRandomized, Multifactorial, Double-blind, Parallel-group, Dose-ranging Study of the Efficacy and Safety of Rituximab (MabThera®/Rituxan®) in Combination With Methotrexate in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: methotrexate;Drug: rituximab;Drug: corticosteroids;Drug: placeboGenentech, Inc.Roche Pharma AGCompleted18 Years80 YearsBoth465Phase 2United States
1228NCT00317538
(ClinicalTrials.gov)
June 200321/4/2006Open-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Switch to Infliximab After Incomplete Response to EtanerceptOpen-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Switch to Infliximab After Incomplete Response to EtanerceptRheumatoid ArthritisDrug: infliximab, etanerceptCentocor Ortho Biotech Services, L.L.C.NULLCompleted18 YearsN/ABoth28Phase 3NULL
1229NCT00062465
(ClinicalTrials.gov)
June 20035/6/2003Treating Rheumatoid Arthritis With Tripterygium Wilfordi Hook F or SulfasalazineA 24-Week, Double Blind, Randomized Study to Determine the Effects of 24 Weeks of Dosing With Tripterygium Wilfordii Hook F (TwHF) or Sulfasalazine, in Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: TwHFNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NULLCompletedN/AN/ABoth157Phase 2United States
1230NCT00396747
(ClinicalTrials.gov)
June 20036/11/2006A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging StudyPhase IV Study of Early RA: a Randomized Magnetic Resonance Imaging Study Comparing the Effects of Methotrexate Alone or in Combination With Infliximab or Intravenous Pulse MethylprednisoloneRheumatoid ArthritisDrug: Infliximab, methylprednisolone, methotrexate;Drug: Methotrexate;Drug: Methotrexate + Methylprednisolone;Drug: Methotrexate + InfliximabUniversité Catholique de LouvainNULLCompleted18 YearsN/ABoth45Phase 4Belgium
1231NCT00468546
(ClinicalTrials.gov)
May 200330/4/2007A Study to Evaluate the Safety and Efficacy of MabThera (Rituximab) in Combination With Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Who Failed on Anti-Tumor Necrosis Factor Alpha TherapyA Randomized, Placebo-controlled, Double-blind, Multicenter Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Alpha TherapiesRheumatoid ArthritisDrug: MabThera/Rituxan;Drug: Methotrexate;Other: PlaceboHoffmann-La RocheBiogenCompleted18 Years80 YearsAll520Phase 3United States;Belgium;Canada;France;Germany;Ireland;Israel;Italy;Netherlands;Norway;United Kingdom
1232NCT00095342
(ClinicalTrials.gov)
May 20032/11/2004Study Evaluating TMI-005 in Active Rheumatoid ArthritisA Double-Blind, Placebo-Controlled, Parallel, Randomized Study to Evaluate the Efficacy and Safety of 3 Oral Dose Levels of TMI-005 in Subjects With Active Rheumatoid Arthritis on a Background of MethotrexateRheumatoid ArthritisDrug: TMI-005Wyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 Years75 YearsBoth390Phase 2United States;Canada
1233NCT02214888
(ClinicalTrials.gov)
May 200312/8/2014Efficacy, Safety and Pharmacokinetics of BIRB 796 BS Tablets in Patients With Active Rheumatoid ArthritisA 12 Week Double-blind, Randomized, Placebo-controlled Trial to Investigate Efficacy, Safety and Pharmacokinetics of BIRB 796 BS Tablets at Doses of 50 and 70 mg Administered Twice a Day in Patients With Active Rheumatoid Arthritis Who Have Failed at Least One DMARDArthritis, RheumatoidDrug: BIRB 796 BS, low dose;Drug: BIRB 796 BS, high dose;Drug: PlaceboBoehringer IngelheimNULLTerminated18 Years75 YearsBoth170Phase 2NULL
1234NCT00563849
(ClinicalTrials.gov)
May 200321/11/2007Leflunomide + Methotrexate in Rheumatoid ArthritisAn Open-Label, Multi-Center Study to Evaluation of Leflunomide Plus Methotexate for the Treatment of Rheumatoid Arthritis in DMARDs:(Disease-Modifying Antirheumatic Drug) na¿ve or Restart (Skip DMARDs More Than 4 Weeks) Subjects.Rheumatoid ArthritisDrug: LeflunomideSanofiNULLCompleted18 Years75 YearsBoth74Phase 4Korea, Republic of
1235NCT00213564
(ClinicalTrials.gov)
April 200313/9/2005Gene Expression Profiling in PBMCs as a Tool for Prediction of Infliximab Responsiveness in Rheumatoid ArthritisGene Expression Profiling in PBMCs as a Tool for Prediction of Infliximab Responsiveness in Rheumatoid ArthritisRheumatoid ArthritisDrug: response to infliximab associated with methotrexateUniversity Hospital, RouenNULLCompleted18 YearsN/ABoth40France
1236NCT00195377
(ClinicalTrials.gov)
April 200313/9/2005Study Evaluating Etanercept in Patients With Rheumatoid Arthritis(RA), Juvenile Idiopathic Arthritis (JIA), or Psoriatic Arthritis (PsA) in SpainEvaluating Safety and QoL in Patients Treated With Etanercept: an Open Multicenter StudyArthritis, Psoriatic;Arthritis, RheumatoidDrug: EtanerceptWyeth is now a wholly owned subsidiary of PfizerNULLCompleted4 YearsN/ABoth1000Spain
1237NCT00908089
(ClinicalTrials.gov)
March 200322/5/2009TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid ArthritisUse of TNF-blocking Therapy in Combination With DMARDs in Patients With Early Rheumatoid ArthritisRheumatoid ArthritisDrug: Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Drug: Trexan+Salazopyrin+Oxiklorin+prednisolone + placeboHelsinki UniversitySeinajoki Central Hospital;Oulu University Hospital;Jyväskylä Central Hospital;Kuopio University Hospital;Satakunta Central Hospital;University of Turku;Rheumatism Foundation Hospital;Orton Invalid Foundation;South Karelia central hospital;Lappi Central Hospital;Central Hospital of Kanta-HameActive, not recruiting18 Years60 YearsBoth100Phase 4Finland
1238NCT00234845
(ClinicalTrials.gov)
March 200313/9/2005Adalimumab in Combination With Methotrexate vs Methotrexate Alone in Early Rheumatoid ArthritisA Multi-Centre Randomized, Double-Blind Study Comparing Adalimumab (D2E7) Plus Methotrexate With Placebo Plus Methotrexate on Work Disability in Subjects With Early Rheumatoid ArthritisRheumatoid ArthritisDrug: adalimumab;Drug: methotrexateAbbottNULLCompleted18 YearsN/ABoth148Phase 3United States
1239NCT00356473
(ClinicalTrials.gov)
March 200325/7/2006Effects of Atorvastatin on Disease Activity and HDL Cholesterol Function in Patients With Rheumatoid ArthritisEffects of Atorvastatin on Disease Activity and HDL Cholesterol Anti-inflammatory Properties in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: AtorvastatinUniversity of California, Los AngelesNULLCompleted18 YearsN/ABoth20Phase 4NULL
1240NCT00144508
(ClinicalTrials.gov)
March 20032/9/2005Phase III Comparative Study(Open-Label) of MRA for Rheumatoid Arthritis(RA)An Open-Label, Phase III Study to Evaluate the Efficacy and Safety of MRA in Patients With RARheumatoid ArthritisDrug: MRA (Tocilizumab);Other: current treatmentChugai PharmaceuticalNULLCompleted20 YearsN/ABoth306Phase 3NULL
1241NCT00244556
(ClinicalTrials.gov)
March 200312/10/2005Study Comparing Enbrel (Etanercept) Plus Methotrexate Versus Enbrel Alone in Active Rheumatoid Arthritis Despite Current Methotrexate TherapyA Randomized Comparison of the Safety and Efficacy of Enbrel (Etanercept) Plus Methotrexate Versus Enbrel Alone in Patients With Active Rheumatoid Arthritis Despite Current Methotrexate TherapyRheumatoid ArthritisDrug: Methotrexate plus ENBREL or ENBREL aloneWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/ABoth300Phase 4NULL
1242NCT00650455
(ClinicalTrials.gov)
February 200328/3/2008Efficacy and Safety of Valdecoxib and Naproxen in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis PatientsClinical Protocol for a Multicenter, Double-Blind, Randomized, Placebo Controlled, Comparison of the Efficacy and Safety of Bextra® (Valdecoxib) 10 mg Once Daily and Naproxen 500 mg Twice Daily in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe RA PopulationArthritis, RheumatoidDrug: valdecoxib;Drug: naproxen;Drug: placeboPfizerNULLCompleted18 YearsN/ABoth489Phase 4United States;Canada
1243NCT00092742
(ClinicalTrials.gov)
February 200323/9/2004Investigational Drug Versus an Approved Drug in Patients With Rheumatoid Arthritis (0663-072)A Randomized, Double-Blind, Multicenter Study to Evaluate the Tolerability and Effectiveness of Etoricoxib 90 mg q.d. vs. Diclofenac Sodium 75 mg b.i.d. in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: MK0663, etoricoxib;Drug: Comparator: Diclofenac sodiumOrganon and CoNULLCompleted50 YearsN/AAll4086Phase 3United States
1244NCT00250445
(ClinicalTrials.gov)
January 20037/11/2005A Study to Evaluate the Safety of an Investigational Drug (Etoricoxib) in Patients With Osteoarthritis (OA) or Rheumatoid Arthritis (RA)(0663-066)A Randomized, Double-Blind, Active-Comparator-Controlled, Parallel-Group Study to Evaluate the Safety of Etoricoxib in Patients With Osteoarthritis or Rheumatoid ArthritisRheumatoid Arthritis,OsteoarthritisDrug: MK0663, etoricoxib;Drug: Comparator: Diclofenac sodiumOrganon and CoNULLCompleted50 YearsN/AAll23498Phase 3NULL
1245NCT00546533
(ClinicalTrials.gov)
January 200318/10/2007Study Evaluating the Efficacy and Safety of EtanerceptOpen-Label Evaluation Of The Efficacy And Safety Of Etanercept In Patients With Active Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: EtanerceptWyeth is now a wholly owned subsidiary of PfizerNULLCompletedN/AN/ABoth40Phase 4NULL
1246NCT00048932
(ClinicalTrials.gov)
December 200211/11/2002A Phase III Study of BMS-188667 in Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Double-blind Abatacept;Drug: Double-blind Placebo;Drug: Open-label AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/AAll1795Phase 3United States
1247NCT00764725
(ClinicalTrials.gov)
December 20021/10/2008Comparison of MTX+Anti-TNF to MTX+Conventional DMARDs in Patients With Early Rheumatoid Arthritis (RA) Who Failed MTX Alone (SWEFOT)A Prospective Randomized, Open, Multi-Center Trial Comparing TNF-Blockade + MTX to MTX+SSZ+HCQ in Patients With Early RA With an Inadequate Response to MTXRheumatoid ArthritisDrug: conventional DMARD combination;Biological: MTX plus anti-TNFKarolinska InstitutetNULLCompleted18 YearsN/ABoth487Phase 4NULL
1248NCT00433875
(ClinicalTrials.gov)
December 20028/2/2007Phase 2 AMG 714 in Rheumatoid ArthritisA Double-Blind, Placebo Controlled, Randomized, Parallel-Group Clinical Trial With Multiple Dose Treatment of Anti-IL 15 Human Monoclonal Antibody (AMG 714) in Patients With Active Rheumatoid Arthritis Who Have Previously Failed One or More Disease Modifying Anti-Rheumatic DrugsRheumatoid ArthritisDrug: AMG 714AmgenNULLCompleted18 YearsN/ABoth180Phase 2NULL
1249NCT00048581
(ClinicalTrials.gov)
December 20022/11/2002Phase III Study of BMS-188667 (CTLA4Ig) in Patients With Rheumatoid Arthritis Who Are Currently Failing Anti-TNF Therapy or Who Have Failed Anti-TNF Therapy in the Past.A Phase III, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of BMS-188667 in Subjects With Active Rheumatoid Arthritis on Background Disease Modifying Anti-Rheumatic Drugs (DMARDS) Who Have Failed Anti-Tumor Necrosis Factor (TNF) TherapyRheumatoid ArthritisDrug: Abatacept;Drug: PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/AAll738Phase 3United States
1250NCT00048568
(ClinicalTrials.gov)
December 20022/11/2002A Phase III Study of Abatacept (BMS-188667) in Patients With Active Rheumatoid Arthritis and Inadequate Response to MethotrexateA Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study and Open-Label Study to Evaluate the Efficacy and Safety of Abatacept in Combination Therapy With Methotrexate Versus Methotrexate Alone in Subjects With Active Rheumatoid Arthritis and Inadequate Response to MethotrexateRheumatoid ArthritisDrug: Abatacept;Drug: Methotrexate;Drug: PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/AAll1250Phase 3United States
1251NCT00482417
(ClinicalTrials.gov)
December 20021/6/2007Efficacy and Safety Study of MK0359 in Patients With Arthritis (0359-017)Rheumatoid ArthritisDrug: MK0359Merck Sharp & Dohme Corp.NULLCompleted18 Years65 YearsBoth11Phase 2NULL
1252NCT00544154
(ClinicalTrials.gov)
October 200215/10/2007Efficacy and Safety of CDP870 and Methotrexate Compared to Methotrexate Alone in Subjects With Rheumatoid ArthritisEfficacy and Safety of CDP870 400 mg in Combination With Methotrexate Compared to Methotrexate Alone in the Treatment of the Signs and Symptoms of Patients With Rheumatoid Arthritis Who Are Partial Responders to MethotrexateArthritis, RheumatoidDrug: CDP870UCB PharmaNULLCompleted18 Years75 YearsBoth247Phase 3NULL
1253NCT00116727
(ClinicalTrials.gov)
October 200230/6/2005Rheumatoid Arthritis DMARD Intervention and UtilizationStudyRheumatoid Arthritis Disease Modifying Anti-Rheumatic Drug (DMARD) Intervention and Utilization Study (RADIUS 2)Rheumatoid ArthritisDrug: ENBREL®AmgenImmunex Corporation;Wyeth is now a wholly owned subsidiary of PfizerCompleted18 YearsN/ABoth5103N/AUnited States
1254NCT00946686
(ClinicalTrials.gov)
September 200224/7/2009To Demonstrate the Relative Bioavailability, Parallel Study Of Leflunomide 20 mg Tablets Under Fasting ConditionsA Relative Bioavailability, Parallel Study Of Leflunomide 20 mg Tablets Under Fasting ConditionsRheumatoid Arthritis;Psoriatic ArthritisDrug: Leflunomide 20 mg Tablets (Geneva Pharmaceutical);Drug: Arava 20 mg Tablets (Aventis Pharmaceutical, Inc.)SandozNULLCompleted18 YearsN/AAll52Phase 1NULL
1255NCT00055133
(ClinicalTrials.gov)
September 200219/2/2003A Study Using Intravenous Paxceed™ to Treat Patients With Rheumatoid ArthritisA Phase 2 Open-Label Clinical Study Using Intravenous Paxceed™ to Treat Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Micellar Paclitaxel for InjectionAngiotech PharmaceuticalsNULLCompleted21 Years70 YearsBoth50Phase 2United States
1256NCT00049751
(ClinicalTrials.gov)
September 200213/11/2002Study of Human Anti-TNF Monoclonal Antibody D2E7 in Subjects With Active Rheumatoid ArthritisA Multicenter Study of the Safety of Human Anti-TNF Monoclonal Antibody D2E7 in Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: AdalimumabAbbottNULLCompleted18 YearsN/ABoth3000Phase 3United States
1257NCT00042406
(ClinicalTrials.gov)
September 200229/7/2002Trial With HuMax-CD4 in Patients With Rheumatoid Arthritis Failing Treatment With Methotrexate and a TNF-alpha BlockerA Double-Blind, Placebo-Controlled, Randomized, Parallel Group Clinical Trial of Anti-CD4 Receptor Human Monoclonal Antibody (HuMax-CD4) in Patients With Active RA Failing Treatment With Methotrexate and TNF-alpha Blocking AgentsRheumatoid ArthritisDrug: HuMax-CD4Emergent Product Development Seattle LLCNULLTerminated18 YearsN/ABoth75Phase 2/Phase 3United States;Canada
1258NCT00121056
(ClinicalTrials.gov)
September 200230/6/2005REKinDLE: Registry With Enbrel® or Kineret® in a Database Using Longitudinal EvaluationsRegistry With Enbrel® or Kineret® in a Database Using Longitudinal Evaluations (REKinDLE)Rheumatoid ArthritisDrug: Enbrel®;Drug: Kineret®AmgenNULLCompleted18 YearsN/ABothN/ANULL
1259NCT00111423
(ClinicalTrials.gov)
August 200220/5/2005Evaluating the Safety of Extended Treatment With Pegsunercept (PEG sTNF-RI)in Subjects With Rheumatoid Arthritis (RA)Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety of Extended Treatment With Pegsunercept (PEG sTNF-RI) in Subjects With Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: Pegsunercept (PEG sTNF-RI)AmgenNULLCompleted18 YearsN/ABoth216Phase 2NULL
1260NCT02093026
(ClinicalTrials.gov)
August 200219/3/2014Extension Study to Assess the Efficacy and Safety of Repeat Treatment With Rituximab (MabThera) in Participants With Active Rheumatoid Arthritis (RA)An Open-label Study of the Efficacy and Safety of Re-treatments With Rituximab (MabThera®/Rituxan®) in Patients With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: Rituximab;Drug: Methotrexate;Drug: Methylprednisolone;Drug: Folic AcidHoffmann-La RocheGenentech, Inc.Completed21 YearsN/AAll465Phase 2United States;Australia;Belgium;Brazil;Canada;Czech Republic;Finland;Germany;Israel;Italy;Mexico;New Zealand;Poland;Spain;Sweden;United Kingdom
1261NCT00043732
(ClinicalTrials.gov)
July 200212/8/2002Safety Study of SCIO-469 to Treat Patients With Active Rheumatoid Arthritis Receiving MethotrexateA Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Study of SCIO-469 in Patients in Active Rheumatoid Arthritis Receiving MethotrexateRheumatoid ArthritisDrug: SCIO-469Scios, Inc.NULLCompleted18 YearsN/ABoth120Phase 2United States
1262NCT00042068
(ClinicalTrials.gov)
June 200222/7/2002A Multi-Center Trial to Compare Three Doses of Meloxicam and Placebo in Patients With Rheumatoid ArthritisA Multi-center, Double-Blind, Randomized, Parallel-Group Trial to Compare the Efficacy and Safety of Three Doses of Meloxicam (7.5, 15, and 22.5 mg) and Placebo in Patients With Rheumatoid ArthritisArthritis, RheumatoidDrug: MeloxicamBoehringer IngelheimNULLCompleted18 Years80 YearsBoth1000Phase 3United States;Argentina;Australia;Belgium;Brazil;Canada;France;Germany;Hungary;Italy;Korea, Republic of;Russian Federation;Taiwan;Ukraine
1263NCT00034060
(ClinicalTrials.gov)
April 200219/4/2002The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With EtanerceptSuppression of the Growth Hormone/ Insulin-Like Growth Factor-1 (GH/IGF-1) Axis in Women With Rheumatoid ArthritisRheumatoid Arthritis;HealthyDrug: EtanerceptNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NULLCompletedN/AN/AFemale36Phase 2United States
1264NCT00038298
(ClinicalTrials.gov)
April 200229/5/2002A Rheumatoid Arthritis (RA) Study Treating Signs and Symptoms of RA in People With RA & Receiving MethotrexateA Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose Ranging Study to Assess the Efficacy, Safety and Tolerability of AMG 719 in Subjects With Rheumatoid Arthritis Receiving MethothrexateRheumatoid ArthritisDrug: Placebo;Drug: AMG 719;Drug: AGM 719;Drug: placebo to AMG 719AmgenNULLCompleted18 YearsN/ABoth53Phase 2United States
1265NCT00034203
(ClinicalTrials.gov)
April 200223/4/2002Safety and Efficacy of a Monoclonal Antibody for Treatment of Rheumatoid Arthritis.Rheumatoid ArthritisDrug: efalizumabXOMA (US) LLCNULLCompleted18 Years80 YearsBothPhase 2United States
1266NCT00959439
(ClinicalTrials.gov)
March 200213/8/2009Relative Bioavailability Study of Naproxen Delayed-Release Tablets (375 mg)A Comparative Bioavailability Study of Naproxen Delayed-Release Tablets, 375mg.Rheumatoid Arthritis;OsteoarthritisDrug: Naproxen Delayed Release Tables, 375 (Gevena Pharmaceuticals, Inc.);Drug: Naproxen (EC-Narosyn) Delayed Release Tables, 375 (Syntex (USA), Inc.)SandozNULLCompleted21 Years50 YearsAll34Phase 1NULL
1267NCT00451971
(ClinicalTrials.gov)
March 200223/3/2007Objective Study in Rheumatoid ArthritisObjective Study in Rheumatoid ArthritisArthritis, RheumatoidDrug: LEFLUNOMIDESanofiNULLCompleted18 Years75 YearsBoth249Phase 4Australia
1268NCT00036153
(ClinicalTrials.gov)
March 20028/5/2002Study to Assess Efficacy of Tacrolimus + Methotrexate Versus Placebo + Methotrexate in Treatment of Rheumatoid ArthritisA Randomized, Double-Blind Study to Assess the Efficacy of Tacrolimus (Prograf®)+ Methotrexate Vs. Placebo + Methotrexate in the Treatment of Rheumatoid Arthritis in Patients With Partial Response to MethotrexateRheumatoid ArthritisDrug: Tacrolimus (Prograf®);Drug: MethotrexateAstellas Pharma IncAstellas Pharma US, Inc.Completed18 YearsN/ABoth210Phase 3United States;Canada
1269NCT00048321
(ClinicalTrials.gov)
January 1, 200229/10/2002ISIS 104838, an Inhibitor of Tumor Necrosis Factor, for Active Rheumatoid ArthritisISIS 104838-CS7, A Double-Blind, Placebo-Controlled, Randomized Trial of the Safety, Efficacy and Pharmacokinetic Profile of ISIS 104838 (TNF-alpha Antisense Oligonucleotide) Subcutaneous Injections in Active Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: ISIS 104838Ionis Pharmaceuticals, Inc.NULLCompleted18 YearsN/AAll160Phase 2United States;Canada
1270NCT00029042
(ClinicalTrials.gov)
January 20024/1/2002Infliximab to Treat Children With Juvenile Rheumatoid ArthritisA Randomized Double Blind Controlled Intra-Patient Dose Escalation Phase II Trial of Infliximab in Pediatric Patients With Refractory Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisDrug: InfliximabNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NULLTerminatedN/AN/ABoth48Phase 2United States
1271NCT00246064
(ClinicalTrials.gov)
December 200128/10/2005The Infliximab Rheumatoid Arthritis Methotrexate Tapering (iRAMT) ProtocolThe Infliximab Rheumatoid Arthritis Methotrexate Tapering (iRAMT) Protocol. Tapering Methotrexate in Patients With Rheumatoid Arthritis Beginning Therapy With InfliximabArthritis, RheumatoidDrug: infliximabCentocor Ortho Biotech Services, L.L.C.NULLCompleted18 Years80 YearsBoth210Phase 4NULL
1272NCT00116714
(ClinicalTrials.gov)
October 200130/6/2005Rheumatoid Arthritis (DMARD) Intervention and UtilizationStudyRheumatoid Arthritis Disease Modifying Anti-Rheumatic Drug (DMARD) Intervention and Utilization Study (RADIUS 1)Rheumatoid ArthritisDrug: DMARDAmgenImmunex Corporation;Wyeth is now a wholly owned subsidiary of PfizerCompleted18 YearsN/ABoth4968N/AUnited States
1273NCT00036387
(ClinicalTrials.gov)
October 20019/5/2002A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Rheumatoid Arthritis.A Randomized, Double-blind Trial of the Safety of Anti-TNF Chimeric Monoclonal Antibody (Infliximab) in Combination With Methotrexate Compared to Methotrexate Alone in Patients With Rheumatoid Arthritis on Standard Disease-modifying Anti-Rheumatic Drug Background Therapy.Arthritis, RheumatoidDrug: InfliximabCentocor, Inc.NULLCompleted18 YearsN/ABoth347Phase 3United States
1274NCT00036374
(ClinicalTrials.gov)
October 20019/5/2002A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid ArthritisA Randomized, Double-Blind Trial of Anti-TNF Chimeric Monoclonal Antibody (Infliximab) in Combination With Methotrexate for the Treatment of Patients With Polyarticular Juvenile Rheumatoid ArthritisRheumatoid Arthritis, JuvenileDrug: InfliximabCentocor, Inc.NULLCompleted4 Years18 YearsBoth123Phase 3United States
1275NCT02180516
(ClinicalTrials.gov)
October 20011/7/2014Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm SyndromeSafety and Efficacy of Meloxicam (MOBIC) Compared to Other NSAIDs in Approved Therapeutic Dosages and Routes of Administration in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm SyndromeArthritis, RheumatoidDrug: Meloxicam;Drug: Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolacBoehringer IngelheimNULLCompletedN/AN/ABoth9984N/ANULL
1276NCT00035334
(ClinicalTrials.gov)
October 20012/5/2002Study of the Safety and Efficacy of NC-503 in Secondary (AA) AmyloidosisA Phase II/III Study of the Safety and Efficacy of NC-503 in Patients Suffering From Secondary (AA) AmyloidosisSecondary (AA) Amyloidosis;Rheumatoid Arthritis;Nephrotic Syndrome;Familial Mediterranean Syndrome;Kidney Diseases;Gastrointestinal DiseasesDrug: NC-503 (Anti-amyloidotic (AA) Agent)Bellus Health IncFDA Office of Orphan Products DevelopmentCompleted18 YearsN/ABoth150Phase 2/Phase 3United States;Finland;France;Israel;Italy;Lithuania;Netherlands;Poland;Russian Federation;Spain;Turkey;United Kingdom
1277NCT00144651
(ClinicalTrials.gov)
August 20012/9/2005Study of MRA in Patients With Rheumatoid Arthritis (RA)An Open-label, Extension, Phase II Study to Evaluate the Long-term Safety and Efficacy of MRA in Patients With RA Who Were Participated in Study MRA009JPRheumatoid ArthritisDrug: MRA(Tocilizumab)Chugai PharmaceuticalNULLCompleted20 YearsN/ABoth135Phase 2NULL
1278NCT00537667
(ClinicalTrials.gov)
August 200127/9/2007The SPECTRA StudyA Single Centre, Open-Label, Randomised, Study to Evaluate the Effect of Anakinra (r-metHuIL-1ra) Alone and in Combination With PEGylated Recombinant Methionyl Human Soluble Tumour Necrosis Factor Receptor Type I (PEG sTNF-RI) on Synovial Inflammation in Subjects With Rheumatoid Arthritis.Rheumatoid ArthritisDrug: anakinra;Drug: anakinra and PEG sTNF-R1AmgenNULLTerminated18 YearsN/ABoth22Phase 2NULL
1279NCT00524160
(ClinicalTrials.gov)
July 200131/8/2007A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, in Patients With Rheumatoid Arthritis or OsteoarthritisOpen-Label Study To Assess The Effect On Pain Control Of Durogesic (Fentanyl Transdermic Therapeutic System) Treatment In Subjects With Rheumatoid Arthritis Or Osteoarthritis Of The Knee Or Hip.Arthritis;Osteoarthritis;Rheumatoid ArthritisDrug: Fentanyl transdermal patchJanssen Pharmaceutica N.V., BelgiumNULLCompleted18 YearsN/ABoth264Phase 4NULL
1280NCT00078806
(ClinicalTrials.gov)
June 4, 20015/3/2004Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisA Phase 3 Safety and Efficacy Study of Etanercept In Children With Systemic Onset Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisDrug: Etanercept;Drug: PlaceboAmgenImmunex CorporationTerminated2 Years18 YearsAll19Phase 3Canada;United States
1281NCT02209779
(ClinicalTrials.gov)
May 20015/8/2014Efficacy and Safety of Different Doses of BIRB 796 BS in Patients With Active Rheumatoid ArthritisA Randomised, Parallel, Double-blind, Placebo-controlled Study to Investigate Efficacy and Safety of Different Doses (5, 10, 20 and 30 mg) of BIRB 796 BS Administered Twice a Day Orally Over 4 Weeks in Patients With Active Rheumatoid Arthritis Who Have Failed at Least One DMARDArthritis, RheumatoidDrug: BIBR 796 BS;Drug: PlaceboBoehringer IngelheimNULLCompleted18 Years75 YearsBoth167Phase 2NULL
1282NCT00037700
(ClinicalTrials.gov)
May 200120/5/2002Evaluation of the Efficacy of Combination Treatment With Anakinra and Pegsunercept in Improving Rheumatoid ArthritisRheumatoid ArthritisDrug: anakinra;Drug: pegsunerceptAmgenNULLCompleted18 YearsN/ABothPhase 2United States
1283NCT02251210
(ClinicalTrials.gov)
May 200125/9/2014Efficacy and Safety of BIIL 284 BS in Adult Patients With Active Rheumatoid ArthritisThree Month, Randomised, Double-blind, Double-dummy, Placebo-controlled, Multiple Dose-range Study of the Efficacy and Safety of BIIL 284 BS (5, 25 and 75 mg p.o. Once Daily) in Adult Patients With Active Rheumatoid ArthritisArthritis, RheumatoidDrug: BIIL 284 BS low dose;Drug: BIIL 284 BS medium dose;Drug: BIIL 284 BS high dose;Drug: PlaceboBoehringer IngelheimNULLCompleted18 Years70 YearsBoth404Phase 2NULL
1284NCT00014794
(ClinicalTrials.gov)
April 200111/4/2001Positron Emission Tomography and Magnetic Resonance Imaging to Evaluate Synovial Blood Flow in Rheumatoid Arthritis PatientsH215O Positron Emission Tomography (PET) in the Assessment of Synovial Blood Flow in Rheumatoid Arthritis PatientsRheumatoid ArthritisDrug: 15-O labeled waterNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NULLCompletedN/AN/ABoth10Phase 1United States
1285NCT02693210
(ClinicalTrials.gov)
February 200123/2/2016A Study to Evaluate the Efficacy and Safety of Mabthera Alone and in Combination With Either Cyclophosphamide or Methotrexate in Patients With Rheumatoid ArthritisA Randomised, Double Dummy Controlled, Parallel Group Study of the Efficacy and Safety of MabThera (Rituximab) Alone or in Combination With Either Cyclophosphamide or Methotrexate, in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Cyclophosphamide;Drug: Methotrexate;Other: Placebo Cyclophosphamide;Other: Placebo Methotrexate;Other: Placebo Rituximab;Drug: RituximabHoffmann-La RocheNULLCompleted21 YearsN/ABoth161Phase 2Australia;Belgium;Canada;Czech Republic;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
1286NCT00579644
(ClinicalTrials.gov)
January 200118/12/2007Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate AloneTreatment of Early Rheumatoid Arthritis: Minocycline in Combination With Methotrexate Versus Methotrexate AloneRheumatoid ArthritisDrug: Combination of Minocycline and MTX or MTX alone;Drug: methotrexateUniversity of NebraskaNULLCompleted19 Years75 YearsAll91Phase 3NULL
1287NCT00034853
(ClinicalTrials.gov)
December 20002/5/2002Meloxicam [Mobic] in Juvenile Rheumatoid Arthritis (JRA)A 12 Week Double-blind Randomized Trial, With a 12 Week Open-label Extension, to Investigate the Efficacy and Safety of Meloxicam Oral Suspension Administered Once Daily and Naproxen Oral Suspension Administered Twice Daily in Children With Juvenile Rheumatoid ArthritisArthritis, Juvenile RheumatoidDrug: meloxicam oral suspension;Drug: naproxen oral suspensionBoehringer IngelheimNULLCompleted2 Years17 YearsBoth180Phase 3United States;Brazil;Mexico;Ukraine;Argentina
1288NCT00162266
(ClinicalTrials.gov)
October 20009/9/2005Abatacept With Methotrexate- Phase IIBA Phase IIB, Multi-Center, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety and Clinical Efficacy of Two Different Doses of BMS-188667 Administered Intravenously to Subjects With Active Rheumatoid Arthritis While Receiving MethotrexateRheumatoid ArthritisDrug: Abatacept (BMS-188667);Drug: PlaceboBristol-Myers SquibbNULLCompleted18 YearsN/AAll524Phase 2United States;Argentina;Australia;Belgium;Canada;France;Germany;Ireland;Netherlands;South Africa;United Kingdom
1289NCT00393471
(ClinicalTrials.gov)
October 200026/10/2006Study Comparing Etanercept Plus Methotrexate to Either Etanercept or Methotrexate Alone in Rheumatoid Arthritis.A Double-Blind Study Evaluating the Efficacy and Safety of the Combination of Etanercept and Methotrexate in Comparison to Etanercept Alone or Methotrexate Alone in Rheumatoid Arthritis Patients.Active Rheumatoid ArthritisDrug: EtanerceptWyeth is now a wholly owned subsidiary of PfizerNULLCompleted18 YearsN/AMale615Phase 3Australia;Austria;Belgium;Czech Republic;Denmark;Finland;France;Germany;Greece;Israel;Italy;Netherlands;Norway;Poland;Portugal;Romania;Spain;Sweden;United Kingdom
1290NCT00162279
(ClinicalTrials.gov)
October 20009/9/2005The Study of Abatacept in Combination With EtanerceptA Multi-Center, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety and Clinical Efficacy of Intravenous Infusions of BMS-188667 (10 mg/kg) Given Monthly in Combination With Subcutaneous Injections of Etanercept (25mg)Given Twice Weekly to Subjects With Active Rheumatoid ArthritisRheumatoid ArthritisDrug: AbataceptBristol-Myers SquibbNULLCompleted18 YearsN/ABoth141Phase 2United States
1291NCT00279747
(ClinicalTrials.gov)
September 200019/1/2006A One Year Double-blind Trial to Investigate the Efficacy and Safety of Meloxicam Oral Suspension in Juvenile Rheumatoid Arthritis (JRA/JIA)A One Year Double-blind Trial to Investigate the Efficacy and Safety of Meloxicam Oral Suspension 0.25mg/kg and 0.125 mg/kg Administered Once Daily in Comparison to Naproxen Oral Suspension 5mg/kg Administered Twice Daily in Children With Juvenile Rheumatoid Arthritis.Arthritis, Juvenile RheumatoidDrug: meloxicam 0.25 mg/kg;Drug: meloxicam 0.125 mg/kg;Drug: naproxen 10 mg/kgBoehringer IngelheimNULLCompleted2 Years16 YearsBoth226Phase 3Austria;Belgium;France;Germany;Italy;Russian Federation;United Kingdom
1292NCT00006292
(ClinicalTrials.gov)
September 200023/9/2000Infliximab for the Treatment of Early Rheumatoid ArthritisRandomized Double Blind Active Treatment Controlled Trial of the Anti-TNF-Alpha Antibody Infliximab in Patients With Erosive Rheumatoid ArthritisRheumatoid ArthritisDrug: InfliximabNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NULLCompletedN/AN/ABoth60Phase 2United States
1293NCT03781375
(ClinicalTrials.gov)
August 24, 200018/12/2018Etanercept Plus Methotrexate Versus Methotrexate Alone in Children With Polyarticular Course Juvenile Rheumatoid ArthritisA Phase III Double Blind Randomized Study Comparing Etanercept (Enbrel) Combined With Methotrexate vs Methotrexate Alone in Children With Polyarticular Course Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisDrug: Etanercept;Drug: Placebo to Etanerceot;Drug: MethotrexateAmgenNULLTerminatedN/AN/AAll25Phase 3NULL
1294NCT00037648
(ClinicalTrials.gov)
July 200017/5/2002Juvenile Rheumatoid ArthritisA Randomized, Multi-center, Blinded, Placebo-controlled Study With an Open-label Run-in Period to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daily, Single, Subcutaneous Injections of r-metHuIL-1ra (Anakinra) in Polyarticular-Course Juvenile Rheumatoid ArthritisJuvenile Chronic ArthritisDrug: Anakinra;Drug: PlaceboAmgenNULLCompleted2 Years17 YearsBoth86Phase 2United States
1295NCT00078793
(ClinicalTrials.gov)
June 20005/3/2004Registry of Etanercept (Enbrel®) In Children With Juvenile Rheumatoid ArthritisPhase IV Registry of Etanercept (Enbrel®) In Children With Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisDrug: Enbrel®AmgenImmunex CorporationCompleted2 Years18 YearsBoth600Phase 4United States;Canada
1296NCT00138983
(ClinicalTrials.gov)
May 200029/8/2005Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol.Prevention of Glucocorticoid-Induced Osteoporosis in Patients With Rheumatic Diseases. The STOP-Study: a Randomized Placebo Controlled Trial With Alendronate Versus Alfacalcidol.Rheumatoid Arthritis;Polymyalgia Rheumatica;Giant Cell Arteritis;Polymyositis;Wegener’s GranulomatosisDrug: Alendronate versus alfacalcidol (1-alpha OH vitamin D)UMC UtrechtDutch Health Care Insurance BoardCompleted18 Years90 YearsBoth200Phase 3Netherlands
1297NCT00132418
(ClinicalTrials.gov)
April 200019/8/2005Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid DisordersDouble-blind, Randomized, Placebo-controlled Study of Enbrel (Etanercept) in the Treatment of Rheumatoid Arthritis Subjects With Comorbid DisordersRheumatoid ArthritisDrug: Enbrel;Drug: PlaceboAmgenImmunex CorporationCompleted18 YearsN/ABoth564Phase 4United States
1298NCT00006055
(ClinicalTrials.gov)
March 20005/7/2000Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune DiseasesPurpura, Schoenlein-Henoch;Graft Versus Host Disease;Anemia, Hemolytic, Autoimmune;Rheumatoid Arthritis;Churg-Strauss Syndrome;Hypersensitivity Vasculitis;Wegener's Granulomatosis;Systemic Lupus Erythematosus;Giant Cell Arteritis;Pure Red Cell Aplasia;Juvenile Rheumatoid Arthritis;Polyarteritis Nodosa;Autoimmune Thrombocytopenic Purpura;Takayasu ArteritisDrug: anti-thymocyte globulin;Drug: cyclophosphamide;Drug: cyclosporine;Drug: filgrastim;Drug: methylprednisolone;Drug: prednisone;Procedure: Autologous Peripheral Blood Stem Cell TransplantationFairview University Medical CenterNULLActive, not recruiting1 Year55 YearsBoth10N/AUnited States
1299NCT00279760
(ClinicalTrials.gov)
January 200018/1/2006Phase I/II Multiple-Dose LEA29Y vs CTLAG4Ig vs Placebo in Rheumatoid ArthritisA Pilot, Multi-Center, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety, Preliminary Clinical Activity and Immunogenicity of Multiple Doses of LEA29Y and CTLA4Ig Administered Intravenously to Subjects With Rheumatoid ArthritisRheumatoid ArthritisDrug: Belatacept;Drug: AbataceptBristol-Myers SquibbNULLCompleted18 Years65 YearsBoth210Phase 1/Phase 2United States;Belgium;Canada;France;Germany;Ireland;Netherlands;Switzerland;United Kingdom
1300NCT02247375
(ClinicalTrials.gov)
January 200019/9/2014Pharmacokinetics, Safety and Efficacy of BIIL 284 BS in Patients With Rheumatoid Arthritis (RA)A Double-blind, Randomized, Three Parallel Group Placebo-controlled Study to Investigate Pharmacokinetics, Effect on Expression of CD11b/CD18 (Mac-1), as Well as Safety and Efficacy of Two Oral Doses of BIIL 284 BS (Dosage: 25 mg Daily, 150 mg Daily) in Patients With Rheumatoid Arthritis Over Two WeeksArthritis, RheumatoidDrug: Low dose of BIIL 284 BS tablets;Drug: High dose of BIIL 284 BS tablets;Drug: PlaceboBoehringer IngelheimNULLCompleted18 Years65 YearsBoth26Phase 1NULL
1301NCT00579878
(ClinicalTrials.gov)
December 199917/12/2007Triple III Comparison of Leflunomide Alone Versus Two DMARD Combinations in the Treatment of Rheumatoid ArthritisTriple III Comparison of Leflunomide Alone Versus Two DMARD Combinations (Leflunomide-Hydroxychloroquine-Sulfasalazine or Methotrexate-Hydroxychloroquine-Sulfasalazine) in the Treatment of Rheumatoid ArthritisRheumatoid ArthritisDrug: Leflunomide;Drug: Methotrexate-Sulfasalazine-Hydroxychloroquine;Drug: Leflunomide-Sulfasalazine-HydroxychloroquineUniversity of NebraskaNULLCompleted19 Years80 YearsAll69Phase 3United States
1302NCT00012506
(ClinicalTrials.gov)
October 199910/3/2001The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid ArthritisUveitis;Arthritis, Juvenile RheumatoidDrug: TNFR:FcNational Eye Institute (NEI)NULLRecruiting2 Years18 YearsBothPhase 3United States
1303NCT00000435
(ClinicalTrials.gov)
September 199921/1/2000dnaJ Peptide for Relieving Rheumatoid ArthritisA Clinical Trial of Shared Epitope Peptides in Rheumatoid Arthritis (RA)Rheumatoid ArthritisDrug: dnaJ peptide;Drug: None-placeboNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NULLCompleted18 Years85 YearsBoth160Phase 2United States
1304NCT00000401
(ClinicalTrials.gov)
July 19993/11/1999Oral Collagen for Rheumatoid ArthritisOpen Label Multicenter Induction of CII Tolerance in Patients With Rheumatoid ArthritisRheumatoid ArthritisDrug: Oral bovine type II collagenUniversity of TennesseeNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed18 Years80 YearsBoth110Phase 2United States
1305NCT00001862
(ClinicalTrials.gov)
February 19993/11/1999TNRF:Fc to Treat Eye Inflammation in Juvenile Rheumatoid ArthritisThe Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid ArthritisJuvenile Rheumatoid Arthritis;UveitisDrug: EnbrelNational Eye Institute (NEI)NULLCompletedN/AN/ABoth15Phase 2United States
1306NCT00209859
(ClinicalTrials.gov)
October 199816/9/2005Methotrexate and Cyclosporine in Treatment of Early Rheumatoid ArthritisCombination Treatment With Methotrexate and Cyclosporine in Early Rheumatoid Arthritis.Rheumatoid ArthritisDrug: Methotrexate;Drug: Intraarticular betamethasone;Drug: Cyclosporine/placebo-cyclosporineHvidovre University HospitalNULLCompleted18 Years75 YearsBoth160Phase 4Denmark
1307NCT00001677
(ClinicalTrials.gov)
June 19983/11/1999Methotrexate Alone Versus Combination of Methotrexate and Subcutaneous Fludarabine for Severe Rheumatoid Arthritis: Safety, Tolerance and EfficacyMethotrexate Alone Versus Combination of Methotrexate and Subcutaneous Fludarabine for Severe Rheumatoid Arthritis: Safety, Tolerance and EfficacyArthritis, Rheumatoid;SynovitisDrug: Methotrexate;Drug: FludarabineNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NULLCompletedN/AN/ABoth40Phase 2United States
1308NCT00001614
(ClinicalTrials.gov)
July 19973/11/1999The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid ArthritisThe Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid ArthritisArthritis, Juvenile Rheumatoid;UveitisDrug: Chicken type II collagenNational Eye Institute (NEI)NULLCompletedN/AN/ABoth13Phase 1United States
1309NCT03780959
(ClinicalTrials.gov)
May 1, 199718/12/2018Safety and Efficacy of Etanercept (Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein [TNFR:Fc]) in Children With Juvenile Rheumatoid Arthritis (JRA)Safety, Population Pharmacokinetics, and Efficacy of Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein (TNFR:Fc) in Children With Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisDrug: Etanercept;Drug: PlaceboAmgenNULLCompleted4 Years18 YearsAll69Phase 2/Phase 3NULL
1310NCT00269867
(ClinicalTrials.gov)
March 199722/12/2005Infliximab Plus Methotrexate for the Treatment of Rheumatoid ArthritisA Placebo-Controlled, Double-Blinded, Randomized Clinical Trial of Anti-TNF Chimeric Monoclonal Antibody (cA2) in Patients With Active Rheumatoid Arthritis Despite Methotrexate TreatmentRheumatoid ArthritisDrug: Placebo;Drug: Infliximab 3 mg/kg;Drug: Infliximab 10 mg/kgCentocor, Inc.NULLCompleted18 Years75 YearsBoth428Phase 3NULL
1311NCT00000395
(ClinicalTrials.gov)
September 19963/11/1999Antifolate Effectiveness in ArthritisMechanisms of Antifolate Efficacy in ArthritisRheumatoid Arthritis;Adjuvant ArthritisDrug: Methotrexate;Dietary Supplement: Folinic acid;Dietary Supplement: Folic acidUniversity of Alabama at BirminghamNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS);Office of Dietary Supplements (ODS)Completed18 Years85 YearsBoth40Phase 2United States
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(ClinicalTrials.gov)
June 199618/1/2000Calcium Supplements for Bone Health in Juvenile Rheumatoid ArthritisCalcium Supplementation for Bone Mineralization in Juvenile Rheumatoid Arthritis (JRA)Juvenile Rheumatoid ArthritisDrug: Calcium carbonateChildren's Hospital Medical Center, CincinnatiNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed6 Years18 YearsBoth192Phase 2United States
1313NCT00004420
(ClinicalTrials.gov)
September 199418/10/1999Study of Gammalinolenic Acid for Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisDrug: gamma-Linolenic acidFDA Office of Orphan Products DevelopmentUniversity of Massachusetts, WorcesterCompleted1 Year15 YearsBoth50N/ANULL