46. 悪性関節リウマチ Malignant rheumatoid arthritis Clinical trials / Disease details
臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228
Showing 1 to 10 of 1,644 diseases
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
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1 | NCT05604885 (ClinicalTrials.gov) | November 30, 2022 | 31/10/2022 | A Dose-range Study of the Safety and Efficacy of Treatment in Adult Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate A Dose-range Study of the Safety and Efficacy of Treatment in Adult Rheumatoid Arthritis Patients Wi ... | A Two-part, Randomized, Double-blind, Multi-center, Placebo-controlled Study of the Dose-range, Safety and Efficacy of 4 and 12 Weeks of Treatment With AP1189 in Adult Rheumatoid Arthritis (RA) Patients With an Inadequate Response to Methotrexate (MTX) Alone - (RESOLVE) A Two-part, Randomized, Double-blind, Multi-center, Placebo-controlled Study of the Dose-range, Safe ... | Rheumatoid Arthritis | Drug: AP1189, 60 mg;Drug: AP1189, 80 mg;Drug: AP1189, 100 mg;Drug: Placebo | SynAct Pharma Aps | NBCD A/S | Recruiting | 18 Years | 85 Years | All | 420 | Phase 2 | Moldova, Republic of |
2 | NCT05594680 (ClinicalTrials.gov) | November 1, 2022 | 18/10/2022 | Cilostazol and Methotrexate in Rheumatoid Arthritis | The Phosphodiesterase 3 Inhibitor Cilostazol as Adjunct to Methotrexate in Patients With Rheumatoid Arthritis The Phosphodiesterase 3 Inhibitor Cilostazol as Adjunct to Methotrexatein Patients With Rheumatoid A ... | Rheumatoid Arthritis | Drug: Cilostazol;Drug: Methotrexate;Drug: Placebo | Tanta University | NULL | Not yet recruiting | 18 Years | 60 Years | All | 70 | Phase 3 | NULL |
3 | NCT05533372 (ClinicalTrials.gov) | October 10, 2022 | 5/9/2022 | MAD Study of IA-14069 | Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IA-14069 in Healthy Subjects, With an Extension to Explore Any Drug-Drug Interaction Potential With Methotrexate (Part 1), and in Patients With Rheumatoid Arthritis, With Preliminary Assessment of Efficacy in Patients (Part 2) Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, ... | Healthy;Rheumatoid Arthritis | Drug: IA-14069;Drug: Placebo;Drug: Methotrexate | ILAb Co., Ltd. | NULL | Recruiting | 18 Years | 70 Years | All | 75 | Phase 1 | United States |
4 | NCT05460832 (ClinicalTrials.gov) | August 29, 2022 | 12/7/2022 | Phase 2b Study of MBS2320 in Participants With Methotrexate-Refractory RA | A Randomised, Double-Blind, Placebo-Controlled, Dose-Ranging Phase 2b Study to Investigate the Efficacy & Safety of MBS2320 in Participants With Moderate to Severe Active Rheumatoid Arthritis With Inadequate Response to Methotrexate Alone A Randomised, Double-Blind, Placebo-Controlled, Dose-Ranging Phase 2b Study to Investigate the Effic ... | Rheumatoid Arthritis | Drug: MBS2320 5 mg;Drug: MBS2320 20 mg;Drug: MBS2320 40 mg;Drug: Placebo | Modern Biosciences Ltd | NULL | Recruiting | 18 Years | 75 Years | All | 224 | Phase 2 | Bosnia and Herzegovina;Bulgaria;Chile;Czechia;Guatemala;Mexico;Poland;Serbia |
5 | ITMCTR2200006086 | 2022-07-01 | 2022-06-10 | Multicenter randomized double-blind clinical trial of Qufeng Zhitong Capsule combined with Methotrexate tablets in the treatment of rheumatoid arthritis Multicenter randomized double-blind clinical trial of Qufeng Zhitong Capsule combined with Methotrex ... | Multicenter randomized double-blind clinical trial of Qufeng Zhitong Capsule combined with Methotrexate tablets in the treatment of rheumatoid arthritis Multicenter randomized double-blind clinical trial of Qufeng Zhitong Capsule combined with Methotrex ... | rheumatoid arthritis | matched group:Methotrexate tablet + qufeng analgesic capsule simulato;experimental group:Methotrexate tablet + qufeng analgesic capsule; matched group:Methotrexatetablet + qufeng analgesic capsule simulato;experimental group:Methotrexate ... | Guang 'anmen Hospital, China Academy of Traditional Chinese Medicine | NULL | Pending | 18 | 75 | Both | matched group:100;experimental group:100; | Phase 4 | China |
6 | NCT05363917 (ClinicalTrials.gov) | June 15, 2022 | 2/5/2022 | Natrunix Versus Methotrexate in Rheumatoid Arthritis | Phase II Double-Blinded, Placebo-Controlled Randomized Study Examining the Safety and Efficacy of Natrunix Versus Methotrexate (+Folate) for the Treatment of Rheumatoid Arthritis Phase II Double-Blinded, Placebo-Controlled Randomized Study Examining the Safety and Efficacy of Na ... | Rheumatoid Arthritis | Drug: Natrunix with MTX placebo (+folate);Drug: Natrunix placebo with MTX (+folate) | XBiotech, Inc. | NULL | Not yet recruiting | 18 Years | N/A | All | 150 | Phase 2 | NULL |
7 | NCT05363891 (ClinicalTrials.gov) | June 15, 2022 | 2/5/2022 | Natrunix or Placebo in Combination With Methotrexate in Rheumatoid Arthritis | Phase II, Double-blind, Placebo-Controlled, Randomized Trial Examining Natrunix in Combination With Methotrexate (+Folate) for the Treatment of Rheumatoid Arthritis Phase II, Double-blind, Placebo-Controlled, Randomized Trial Examining Natrunix in Combination With ... | Rheumatoid Arthritis | Drug: Natrunix;Drug: Placebo | XBiotech, Inc. | NULL | Not yet recruiting | 18 Years | N/A | All | 150 | Phase 2 | NULL |
8 | NCT05374785 (ClinicalTrials.gov) | May 1, 2022 | 4/5/2022 | Efficacy and Safety Study Comparing CPL409116 to Placebo in Participants With Active Rheumatoid Arthritis Efficacy and Safety Study Comparing CPL409116 to Placebo in Participants With Active Rheumatoid Arth ... | A 12-week, Phase II, Multicentre, Randomised, Double Blind, Efficacy and Safety Study Comparing CPL409116 to Placebo, in Combination With Methotrexate in Participants With Active Rheumatoid Arthritis Who Have an Inadequate Response to MTX A 12-week, Phase II, Multicentre, Randomised, Double Blind, Efficacy and Safety Study Comparing CPL4 ... | Rheumatoid Arthritis | Drug: CPL409116;Other: Placebo | Celon Pharma SA | National Center for Research and Development, Poland | Recruiting | 18 Years | 75 Years | All | 100 | Phase 2 | Poland |
9 | NCT05380934 (ClinicalTrials.gov) | May 2022 | 16/5/2022 | A Clinical Trial of Safety and Tolerance of TQH3821 Tablets in Adult Healthy Subjects | A Randomized, Double-blind, Placebo-controlled Phase I Clinical Trial of TQH3821 in Adult Healthy Subjects A Randomized, Double-blind, Placebo-controlled Phase I Clinical Trial of TQH3821 in Adult Healthy Su ... | Rheumatoid Arthritis | Drug: TQH3821 tablets;Drug: TQH3821 tablets (Placebo);Drug: Methotrexate tablets | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | NULL | Recruiting | 18 Years | 55 Years | All | 62 | Phase 1 | China |
10 | NCT05166304 (ClinicalTrials.gov) | April 2022 | 8/12/2021 | Rebamipide in Patients With Active Rheumatoid Arthritis | Rebamipide as an Adjunct to Methotrexate in Patients With Active Rheumatoid Arthritis | Rheumatoid Arthritis | Drug: Rebamipide;Drug: Placebo | October 6 University | NULL | Not yet recruiting | 18 Years | 60 Years | All | 100 | Phase 1/Phase 2 | NULL |