46. 悪性関節リウマチ Malignant rheumatoid arthritis Clinical trials / Disease details
臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04170426 (ClinicalTrials.gov) | December 2022 | 18/11/2019 | Autologous Adipose-derived Stem Cells (AdMSCs) for Rheumatoid Arthritis | Phase 1/2a Clinical Study for Subjects With Rheumatoid Arthritis (RA) Using Multiple Dose Intravenous Infusions of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells (AdMSCs) | Rheumatoid Arthritis | Biological: autologous adipose derived stem cells | Celltex Therapeutics Corporation | NULL | Not yet recruiting | 18 Years | 75 Years | All | 54 | Phase 1/Phase 2 | NULL |
| 2 | NCT05379322 (ClinicalTrials.gov) | July 2022 | 12/5/2022 | The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis Patients | The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis Patients | Rheumatoid Arthritis | Drug: Anti-TNF;Drug: JAK inhibitor | Abu Dhabi Stem Cells Center | NULL | Withdrawn | 18 Years | N/A | All | 0 | Phase 3 | United Arab Emirates |
| 3 | ChiCTR1800018338 | 2019-01-01 | 2018-09-12 | A Clinical Trial for Human Gingiva Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis | A Clinical Trial for Human Gingiva Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis | Rheumatoid Arthritis | Control:Normal Saline iv. besides MTX treatment;Treatment:GMSC iv. besides MTX treatment; | theThird Affiliated Hospital of Sun Yat-sen University | NULL | Pending | 18 | 65 | Both | Control:123;Treatment:123; | I (Phase 1 study) | China |
| 4 | NCT03691909 (ClinicalTrials.gov) | September 25, 2018 | 27/9/2018 | Phase 1/2a Clinical Trial to Assess the Safety of HB-adMSCs for the Treatment of Rheumatoid Arthritis | A Phase 1/2a Clinical Trial to Assess Safety of a Single IV Infusion of Autologous Adipose-derived Mesenchymal Stem Cells in Adults With Active Rheumatoid Arthritis | Rheumatoid Arthritis | Biological: HB-adMSCs | Hope Biosciences | NULL | Completed | 18 Years | 65 Years | All | 15 | Phase 1/Phase 2 | United States |
| 5 | NCT03798028 (ClinicalTrials.gov) | December 26, 2017 | 7/1/2019 | The Safety and Effects of Mesenchymal Stem Cell (MSCs) in the Treatment of Rheumatoid Arthritis | The Effects and Safety of Mesenchymal Stem Cells in the Treatment of Moderate/Severe Rheumatoid Arthritis, a Multicenter Randomized Controlled Clinical Study | Rheumatoid Arthritis | Biological: UC-MSCs | Xijing Hospital | Changhai Hospital;Southwest Hospital, China | Unknown status | 18 Years | 70 Years | All | 250 | N/A | China |
| 6 | NCT03186417 (ClinicalTrials.gov) | December 15, 2017 | 12/6/2017 | Mesenchymal Stem Cells in Early Rheumatoid Arthritis | Cell-Based Therapy in Rheumatoid Arthritis: Proof of Concept Phase 1 Trial | Rheumatoid Arthritis | Biological: 2 million hMSC/kg;Biological: 4 million hMSC/kg;Biological: 6 million hMSC/kg;Biological: placebo | MetroHealth Medical Center | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Recruiting | 18 Years | 80 Years | All | 20 | Phase 1 | United States |
| 7 | NCT03067870 (ClinicalTrials.gov) | November 2016 | 25/2/2017 | Transplantation of Autologous Bone Marrow Derived Stem Cells in Patients With Rheumatoid Arthritis | Transplantation of Autologous Purified Bone Marrow Derived Specific Populations of Stem Cells and Mesenchymal Stem Cells in Patients With Rheumatoid Arthritis | RheumatoId Arthritis;Osteoarthritis, Knee;Osteoarthritis, Hip | Biological: Stem Cell Transplantation | Stem Cells Arabia | NULL | Active, not recruiting | 17 Years | 75 Years | All | 100 | Phase 1 | NULL |
| 8 | NCT03333681 (ClinicalTrials.gov) | June 20, 2016 | 14/9/2017 | Evaluation of Stem Cell Therapy Effects on the Immune Response in Rheumatoid Arthritis Patients | Evaluation of Mesenchymal Stem Cell Therapy Effects on the Cellular and Humoral Immune Responses and Additionally Study on the Effect of Chemokines in Homing of the Immune Cells in Refractory Rheumatoid Arthritis Patients | Rheumatoid Arthritis | Biological: Autologous mesenchymal stem cells | Mashhad University of Medical Sciences | NULL | Completed | 35 Years | 60 Years | Female | 15 | Phase 1 | NULL |
| 9 | NCT02643823 (ClinicalTrials.gov) | January 2016 | 23/12/2015 | Human Umbilical Cord-Mesenchymal Stem Cells for Rheumatoid Arthritis | Safety and Efficacy Study of Human Umbilical Cord-Mesenchymal Stem Cells for Rheumatoid Arthritis | Rheumatoid Arthritis | Biological: hUC-MSC + DMARDs;Drug: DMARDs | Shenzhen Hornetcorn Bio-technology Company, LTD | Futian People's Hospital | Recruiting | 18 Years | 80 Years | Both | 40 | Phase 1 | China |
| 10 | NCT01985464 (ClinicalTrials.gov) | October 2013 | 31/10/2013 | Umbilical Cord Tissue-derived Mesenchymal Stem Cells for Rheumatoid Arthritis | Feasibility Study of Umbilical Cord Tissue Derived Mesenchymal Stem Cells (UC-MSC) in Disease Modifying Anti-Rheumatic Drugs (DMARD) Resistant Rheumatoid Arthritis | Rheumatoid Arthritis | Biological: Umbilical cord mesenchymal stem cells | Translational Biosciences | NULL | Unknown status | 18 Years | N/A | All | 20 | Phase 1/Phase 2 | Panama |
| 11 | NCT01547091 (ClinicalTrials.gov) | April 2013 | 22/2/2012 | Safety and Efficacy Study of Umbilical Cord-Derived Mesenchymal Stem Cells for Rheumatoid Arthritis | Clinical Trial of Umbilical Cord-Derived Mesenchymal Stem Cells Transplantation for Rheumatoid Arthritis-Phase I/II | Rheumatoid Arthritis | Biological: Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs);Drug: Rheumatoid Arthritis With Disease-Modifying Drugs (DMARDs);Biological: UC-MSC+DMARDS | Alliancells Bioscience Corporation Limited | NULL | Recruiting | 18 Years | 70 Years | Both | 200 | Phase 1/Phase 2 | China |
| 12 | NCT01663116 (ClinicalTrials.gov) | March 2011 | 5/8/2011 | Cx611-0101, eASCs Intravenous Administration to Refractory Rheumatoid Arthritis Patients | Phase Ib/IIa, Escalating Dose, Single Blind, Clinical Trial to Assess the Safety of the i.v Administration of Allogeneic Adipose-derived Mesenchymal Cells (eASCs) to Refractory Rheumatoid Arthritis (RA) Patients. | Rheumatoid Arthritis Aggravated | Genetic: Stem cells;Genetic: Placebo | Tigenix S.A.U. | NULL | Completed | 18 Years | N/A | All | 53 | Phase 1/Phase 2 | Spain |
| 13 | NCT01873625 (ClinicalTrials.gov) | October 2009 | 5/6/2013 | Transplantation of Bone Marrow Derived Mesenchymal Stem Cells in Affected Knee Osteoarthritis by Rheumatoid Arthritis | Resurfacing Articular Cartilage With Mesenchymal Stem Cells Transplantation in Patients With Knee Joint Osteoarthritis Affected by Rheumatoid Arthritis: Randomized Triple Blind Clinical Trial Phase II/III (ACRCT) | Rheumatoid Arthritis | Biological: mesenchymal cell transplantation;Biological: placebo | Royan Institute | NULL | Completed | 10 Years | 65 Years | Both | 60 | Phase 2/Phase 3 | Iran, Islamic Republic of |